locus-tag	class	description
FOF52_RS00005	COG1002	Type II restriction enzyme, methylase subunits
FOF52_RS00010	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
FOF52_RS00065	COG0210	DNA helicase
FOF52_RS00070	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
FOF52_RS00070	COG0758	DNA mediated transformation
FOF52_RS00125	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FOF52_RS00130	COG1120	ATPase activity
FOF52_RS00150	COG1132	(ABC) transporter
FOF52_RS00160	COG2226	methyltransferase
FOF52_RS00175	COG0583	DNA-binding transcription factor activity
FOF52_RS00190	COG0604	alcohol dehydrogenase
FOF52_RS00190	COG1028	Short-chain dehydrogenase reductase Sdr
FOF52_RS00190	COG3321	synthase
FOF52_RS00225	COG2885	chlorophyll binding
FOF52_RS00235	COG1012	belongs to the aldehyde dehydrogenase family
FOF52_RS00260	COG0750	zinc metalloprotease
FOF52_RS00265	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
FOF52_RS00325	COG0124	histidyl-tRNA synthetase
FOF52_RS00335	COG0653	protein targeting
FOF52_RS00365	COG1271	oxidase subunit
FOF52_RS00370	COG2197	response regulator
FOF52_RS00375	COG4585	Histidine kinase
FOF52_RS00395	COG0442	prolyl-tRNA aminoacylation
FOF52_RS00410	COG0779	Required for maturation of 30S ribosomal subunits
FOF52_RS00425	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
FOF52_RS00435	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
FOF52_RS00440	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
FOF52_RS00450	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
FOF52_RS00455	COG1185	polyribonucleotide nucleotidyltransferase activity
FOF52_RS00460	COG0612	Peptidase, M16
FOF52_RS00465	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
FOF52_RS00470	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
FOF52_RS00485	COG1950	PFAM Membrane protein of
FOF52_RS00490	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FOF52_RS00495	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
FOF52_RS00500	COG1674	ftsk spoiiie
FOF52_RS00510	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
FOF52_RS00520	COG1546	Belongs to the CinA family
FOF52_RS00520	COG1058	Belongs to the CinA family
FOF52_RS00525	COG1396	sequence-specific DNA binding
FOF52_RS00550	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
FOF52_RS00550	COG1372	Participates in initiation and elongation during chromosome replication
FOF52_RS00555	COG2137	regulation of response to DNA damage stimulus
FOF52_RS00560	COG1418	mRNA catabolic process
FOF52_RS00560	COG1566	PFAM secretion protein HlyD family protein
FOF52_RS00565	COG1505	serine-type exopeptidase activity
FOF52_RS00570	COG0765	amino acid transport
FOF52_RS00575	COG0765	amino acid transport
FOF52_RS00580	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FOF52_RS00585	COG1126	abc transporter atp-binding protein
FOF52_RS00590	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
FOF52_RS00610	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
FOF52_RS00615	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
FOF52_RS00630	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
FOF52_RS00635	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
FOF52_RS00640	COG1228	amidohydrolase
FOF52_RS00665	COG1555	photosystem II stabilization
FOF52_RS00670	COG0268	Binds directly to 16S ribosomal RNA
FOF52_RS00680	COG0481	GTPase activity
FOF52_RS00685	COG3833	ABC-type maltose transport systems, permease component
FOF52_RS00690	COG1175	transmembrane transport
FOF52_RS00700	COG0366	Alpha amylase catalytic
FOF52_RS00710	COG2258	MOSC domain
FOF52_RS00735	COG1420	regulation of RNA biosynthetic process
FOF52_RS00740	COG0484	heat shock protein binding
FOF52_RS00765	COG0537	adenosine 5'-monophosphoramidase activity
FOF52_RS00775	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
FOF52_RS00790	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
FOF52_RS00795	COG1414	Transcriptional regulator
FOF52_RS00805	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
FOF52_RS00810	COG2340	Cysteine-rich secretory protein family
FOF52_RS00815	COG1381	Involved in DNA repair and RecF pathway recombination
FOF52_RS00820	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
FOF52_RS00840	COG1108	ABC-type Mn2 Zn2 transport systems permease components
FOF52_RS00845	COG1121	(ABC) transporter
FOF52_RS00860	COG0423	glycine-tRNA ligase activity
FOF52_RS00870	COG0574	Belongs to the PEP-utilizing enzyme family
FOF52_RS00870	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
FOF52_RS00880	COG0232	Belongs to the dGTPase family. Type 2 subfamily
FOF52_RS00885	COG0358	DNA primase activity
FOF52_RS00890	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
FOF52_RS00930	COG0659	secondary active sulfate transmembrane transporter activity
FOF52_RS00935	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
FOF52_RS00950	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
FOF52_RS00950	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
FOF52_RS00965	COG1476	TRANSCRIPTIONal
FOF52_RS01005	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
FOF52_RS01015	COG1846	Transcriptional regulator
FOF52_RS01020	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
FOF52_RS01045	COG3546	catalase activity
FOF52_RS01100	COG2192	nodulation
FOF52_RS01105	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
FOF52_RS01120	COG0438	transferase activity, transferring glycosyl groups
FOF52_RS01125	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
FOF52_RS01130	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
FOF52_RS01130	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
FOF52_RS01135	COG1028	Short-chain dehydrogenase reductase Sdr
FOF52_RS01140	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FOF52_RS01180	COG3550	peptidyl-serine autophosphorylation
FOF52_RS01245	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
FOF52_RS01270	COG1349	DNA-binding transcription factor activity
FOF52_RS01290	COG0601	transmembrane transport
FOF52_RS01295	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FOF52_RS01300	COG0444	Belongs to the ABC transporter superfamily
FOF52_RS01330	COG4585	Histidine kinase
FOF52_RS01335	COG2197	response regulator
FOF52_RS01360	COG1522	sequence-specific DNA binding
FOF52_RS01365	COG3483	tryptophan 2,3-dioxygenase activity
FOF52_RS01400	COG0167	dihydroorotate dehydrogenase activity
FOF52_RS01430	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
FOF52_RS01435	COG2011	ABC-type metal ion transport system permease component
FOF52_RS01440	COG1464	Belongs to the NlpA lipoprotein family
FOF52_RS01455	COG0395	ABC-type sugar transport system, permease component
FOF52_RS01460	COG2723	6-phospho-beta-galactosidase activity
FOF52_RS01485	COG2018	Roadblock/LC7 domain
FOF52_RS01500	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
FOF52_RS01510	COG1960	acyl-CoA dehydrogenase activity
FOF52_RS01520	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
FOF52_RS01530	COG1252	NADH dehydrogenase
FOF52_RS01540	COG1937	Protein conserved in bacteria
FOF52_RS01585	COG0686	Belongs to the AlaDH PNT family
FOF52_RS01590	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
FOF52_RS01600	COG3336	cytochrome c oxidase
FOF52_RS01665	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FOF52_RS01670	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
FOF52_RS01675	COG0174	glutamine synthetase
FOF52_RS01680	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
FOF52_RS01680	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
FOF52_RS01695	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
FOF52_RS01720	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
FOF52_RS01725	COG0321	lipoyl(octanoyl) transferase activity
FOF52_RS01730	COG0508	dehydrogenase complex catalyzes the overall conversion of
FOF52_RS01735	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FOF52_RS01740	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
FOF52_RS01745	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
FOF52_RS01750	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
FOF52_RS01760	COG4717	serine-type aminopeptidase activity
FOF52_RS01765	COG0420	3'-5' exonuclease activity
FOF52_RS01780	COG0667	Aldo Keto reductase
FOF52_RS01800	COG0501	Belongs to the peptidase M48B family
FOF52_RS01810	COG1929	Belongs to the glycerate kinase type-1 family
FOF52_RS01820	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FOF52_RS01825	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
FOF52_RS01835	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
FOF52_RS01840	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
FOF52_RS01855	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
FOF52_RS01860	COG0723	plastoquinol--plastocyanin reductase activity
FOF52_RS01865	COG2010	Cytochrome c
FOF52_RS01870	COG1845	cytochrome c oxidase, subunit III
FOF52_RS01880	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
FOF52_RS01925	COG1940	carbohydrate kinase activity
FOF52_RS01950	COG0301	tRNA thio-modification
FOF52_RS01955	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
FOF52_RS01960	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
FOF52_RS01965	COG0515	serine threonine protein kinase
FOF52_RS01965	COG2815	serine threonine protein kinase
FOF52_RS01970	COG2022	thiamine diphosphate biosynthetic process
FOF52_RS01980	COG2022	thiamine diphosphate biosynthetic process
FOF52_RS01980	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FOF52_RS01990	COG0352	thiamine-phosphate diphosphorylase activity
FOF52_RS02015	COG0142	geranyltranstransferase activity
FOF52_RS02025	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
FOF52_RS02030	COG0540	Belongs to the ATCase OTCase family
FOF52_RS02035	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
FOF52_RS02040	COG0505	Belongs to the CarA family
FOF52_RS02045	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
FOF52_RS02050	COG0543	2 iron, 2 sulfur cluster binding
FOF52_RS02055	COG0167	dihydroorotate dehydrogenase activity
FOF52_RS02060	COG0284	orotidine-5'-phosphate decarboxylase activity
FOF52_RS02070	COG0194	GDP metabolic process
FOF52_RS02075	COG1758	RNA polymerase activity
FOF52_RS02085	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
FOF52_RS02100	COG2311	Membrane
FOF52_RS02120	COG1960	acyl-CoA dehydrogenase activity
FOF52_RS02125	COG1804	L-carnitine dehydratase bile acid-inducible protein F
FOF52_RS02145	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
FOF52_RS02160	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
FOF52_RS02170	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
FOF52_RS02180	COG3201	nicotinamide mononucleotide transporter
FOF52_RS02185	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
FOF52_RS02185	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
FOF52_RS02190	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
FOF52_RS02205	COG2017	converts alpha-aldose to the beta-anomer
FOF52_RS02210	COG0515	serine threonine protein kinase
FOF52_RS02210	COG2815	serine threonine protein kinase
FOF52_RS02225	COG1846	Transcriptional regulator
FOF52_RS02240	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
FOF52_RS02245	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
FOF52_RS02250	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
FOF52_RS02255	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
FOF52_RS02260	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
FOF52_RS02270	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
FOF52_RS02290	COG0714	Associated with various cellular activities
FOF52_RS02295	COG2001	Belongs to the MraZ family
FOF52_RS02300	COG0275	rRNA processing
FOF52_RS02310	COG0768	penicillin binding
FOF52_RS02315	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
FOF52_RS02325	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
FOF52_RS02330	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
FOF52_RS02340	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
FOF52_RS02345	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
FOF52_RS02355	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
FOF52_RS02360	COG1496	oxidoreductase activity
FOF52_RS02365	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
FOF52_RS02370	COG1799	cell septum assembly
FOF52_RS02380	COG3599	regulation of cell shape
FOF52_RS02390	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
FOF52_RS02400	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
FOF52_RS02445	COG2188	Transcriptional regulator
FOF52_RS02470	COG2318	DinB family
FOF52_RS02495	COG2153	protein acetylation
FOF52_RS02515	COG2814	Major facilitator Superfamily
FOF52_RS02520	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FOF52_RS02530	COG1132	(ABC) transporter
FOF52_RS02560	COG1695	Transcriptional regulator
FOF52_RS02570	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
FOF52_RS02580	COG1528	Iron-storage protein
FOF52_RS02585	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
FOF52_RS02590	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
FOF52_RS02595	COG0131	Imidazoleglycerol-phosphate dehydratase
FOF52_RS02605	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
FOF52_RS02610	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
FOF52_RS02615	COG0107	imidazoleglycerol-phosphate synthase activity
FOF52_RS02625	COG1132	(ABC) transporter
FOF52_RS02635	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
FOF52_RS02660	COG0134	indole-3-glycerol-phosphate synthase activity
FOF52_RS02665	COG0133	tryptophan synthase activity
FOF52_RS02670	COG0159	tryptophan synthase activity
FOF52_RS02685	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
FOF52_RS02730	COG0693	protein deglycase activity
FOF52_RS02810	COG0539	negative regulation of cytoplasmic translation
FOF52_RS02815	COG0237	dephospho-CoA kinase activity
FOF52_RS02830	COG0556	nucleotide-excision repair
FOF52_RS02845	COG0504	CTP synthase activity
FOF52_RS02850	COG0494	nUDIX hydrolase
FOF52_RS02870	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
FOF52_RS02875	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
FOF52_RS02895	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
FOF52_RS02900	COG1160	GTP binding
FOF52_RS02915	COG1683	Conserved Protein
FOF52_RS02930	COG2267	carboxylic ester hydrolase activity
FOF52_RS02940	COG0318	PFAM AMP-dependent synthetase and ligase
FOF52_RS02945	COG1960	acyl-CoA dehydrogenase activity
FOF52_RS02950	COG0318	PFAM AMP-dependent synthetase and ligase
FOF52_RS02960	COG1309	transcriptional regulator
FOF52_RS02965	COG0483	inositol monophosphate 1-phosphatase activity
FOF52_RS03045	COG1609	Transcriptional regulator
FOF52_RS03070	COG0596	Alpha beta hydrolase
FOF52_RS03075	COG0583	DNA-binding transcription factor activity
FOF52_RS03080	COG0477	Major facilitator Superfamily
FOF52_RS03090	COG3795	YCII-related domain
FOF52_RS03100	COG4221	oxidoreductase activity
FOF52_RS03105	COG0667	Aldo Keto reductase
FOF52_RS03125	COG2197	response regulator
FOF52_RS03140	COG0477	Major facilitator Superfamily
FOF52_RS03215	COG4326	sporulation control protein
FOF52_RS03240	COG1024	Enoyl-CoA hydratase
FOF52_RS03245	COG0110	maltose O-acetyltransferase activity
FOF52_RS03260	COG1309	transcriptional regulator
FOF52_RS03270	COG2226	methyltransferase
FOF52_RS03295	COG1253	flavin adenine dinucleotide binding
FOF52_RS03305	COG3622	Belongs to the hyi family
FOF52_RS03310	COG2084	Dehydrogenase
FOF52_RS03320	COG2207	Transcriptional regulator
FOF52_RS03320	COG3708	Transcriptional regulator
FOF52_RS03330	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
FOF52_RS03395	COG0604	alcohol dehydrogenase
FOF52_RS03405	COG0183	Belongs to the thiolase family
FOF52_RS03415	COG1024	Enoyl-CoA hydratase
FOF52_RS03420	COG1960	acyl-CoA dehydrogenase activity
FOF52_RS03425	COG1960	acyl-CoA dehydrogenase activity
FOF52_RS03430	COG1028	Short-chain dehydrogenase reductase Sdr
FOF52_RS03445	COG2030	dehydratase
FOF52_RS03450	COG1012	belongs to the aldehyde dehydrogenase family
FOF52_RS03455	COG1804	L-carnitine dehydratase bile acid-inducible protein F
FOF52_RS03465	COG0683	leucine binding
FOF52_RS03470	COG0559	Belongs to the binding-protein-dependent transport system permease family
FOF52_RS03505	COG1028	Short-chain dehydrogenase reductase Sdr
FOF52_RS03520	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FOF52_RS03540	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
FOF52_RS03545	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FOF52_RS03565	COG3842	ATPase activity
FOF52_RS03570	COG1840	ABC-type Fe3 transport system, periplasmic component
FOF52_RS03580	COG0517	IMP dehydrogenase activity
FOF52_RS03580	COG0617	tRNA 3'-terminal CCA addition
FOF52_RS03580	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
FOF52_RS03605	COG0300	oxidoreductase activity
FOF52_RS03610	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
FOF52_RS03630	COG1162	GTPase activity
FOF52_RS03655	COG5002	protein histidine kinase activity
FOF52_RS03680	COG2267	carboxylic ester hydrolase activity
FOF52_RS03695	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
FOF52_RS03720	COG1357	PFAM Pentapeptide repeats (8 copies)
FOF52_RS03725	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
FOF52_RS03730	COG2815	serine threonine protein kinase
FOF52_RS03730	COG0515	serine threonine protein kinase
FOF52_RS03745	COG1285	pathogenesis
FOF52_RS03750	COG3387	PFAM Glycoside hydrolase 15-related
FOF52_RS03760	COG2267	carboxylic ester hydrolase activity
FOF52_RS03765	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
FOF52_RS03800	COG0515	serine threonine protein kinase
FOF52_RS03810	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
FOF52_RS03885	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
FOF52_RS03955	COG1690	Belongs to the RtcB family
FOF52_RS04010	COG0746	molybdenum cofactor guanylyltransferase activity
FOF52_RS04035	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
FOF52_RS04040	COG1316	TRANSCRIPTIONal
FOF52_RS04050	COG4555	ABC transporter
FOF52_RS04065	COG2186	Transcriptional regulator
FOF52_RS04070	COG2807	transmembrane transport
FOF52_RS04090	COG1960	acyl-CoA dehydrogenase activity
FOF52_RS04130	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
FOF52_RS04130	COG0512	Glutamine amidotransferase of anthranilate synthase
FOF52_RS04150	COG1966	Carbon starvation protein
FOF52_RS04160	COG0003	Pfam Anion-transporting ATPase
FOF52_RS04165	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
FOF52_RS04175	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
FOF52_RS04195	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
FOF52_RS04195	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
FOF52_RS04210	COG1476	TRANSCRIPTIONal
FOF52_RS04215	COG1515	deoxyribonuclease V activity
FOF52_RS04230	COG2197	response regulator
FOF52_RS04255	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
FOF52_RS04265	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
FOF52_RS04270	COG4948	Mandelate Racemase Muconate Lactonizing
FOF52_RS04275	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
FOF52_RS04280	COG0589	response to stress
FOF52_RS04300	COG1649	PFAM Uncharacterised BCR, COG1649
FOF52_RS04330	COG1289	transmembrane transporter activity
FOF52_RS04345	COG0583	DNA-binding transcription factor activity
FOF52_RS04360	COG5006	permease, DMT superfamily
FOF52_RS04380	COG0598	Magnesium transport protein CorA
FOF52_RS04465	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FOF52_RS04585	COG2365	Tyrosine phosphatase family
FOF52_RS04590	COG2271	Major facilitator Superfamily
FOF52_RS04610	COG1902	pentaerythritol trinitrate reductase activity
FOF52_RS04630	COG0714	Associated with various cellular activities
FOF52_RS04640	COG3552	Protein containing von Willebrand factor type A (VWA) domain
FOF52_RS04660	COG2197	response regulator
FOF52_RS04665	COG4585	Histidine kinase
FOF52_RS04685	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FOF52_RS04695	COG1028	Short-chain dehydrogenase reductase Sdr
FOF52_RS04700	COG1169	isochorismate synthase
FOF52_RS04705	COG3433	isochorismatase activity
FOF52_RS04705	COG1535	isochorismatase
FOF52_RS04710	COG1021	2,3-dihydroxybenzoate-AMP ligase
FOF52_RS04715	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
FOF52_RS04715	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
FOF52_RS04720	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
FOF52_RS04720	COG2226	methyltransferase
FOF52_RS04720	COG3433	isochorismatase activity
FOF52_RS04745	COG1132	(ABC) transporter
FOF52_RS04745	COG2375	cellular response to nickel ion
FOF52_RS04760	COG3959	Transketolase, thiamine diphosphate binding domain
FOF52_RS04765	COG4166	transmembrane transport
FOF52_RS04775	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FOF52_RS04780	COG4172	Belongs to the ABC transporter superfamily
FOF52_RS04785	COG3458	cephalosporin-C deacetylase activity
FOF52_RS04805	COG1012	belongs to the aldehyde dehydrogenase family
FOF52_RS04830	COG1028	Short-chain dehydrogenase reductase Sdr
FOF52_RS04840	COG1960	acyl-CoA dehydrogenase activity
FOF52_RS04845	COG2070	2-Nitropropane dioxygenase
FOF52_RS04870	COG1028	Short-chain dehydrogenase reductase Sdr
FOF52_RS04885	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
FOF52_RS04900	COG1804	L-carnitine dehydratase bile acid-inducible protein F
FOF52_RS04905	COG1804	L-carnitine dehydratase bile acid-inducible protein F
FOF52_RS04935	COG0657	acetylesterase activity
FOF52_RS04940	COG0446	pyridine nucleotide-disulphide oxidoreductase
FOF52_RS04940	COG1902	pentaerythritol trinitrate reductase activity
FOF52_RS04950	COG2072	flavoprotein involved in K transport
FOF52_RS04960	COG1595	DNA-templated transcription, initiation
FOF52_RS04985	COG1302	Protein conserved in bacteria
FOF52_RS05010	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FOF52_RS05015	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FOF52_RS05020	COG1120	ATPase activity
FOF52_RS05050	COG0431	NADPH-dependent FMN reductase
FOF52_RS05055	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FOF52_RS05060	COG0745	RESPONSE REGULATOR receiver
FOF52_RS05065	COG1414	Transcriptional regulator
FOF52_RS05075	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
FOF52_RS05080	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FOF52_RS05085	COG1116	anion transmembrane transporter activity
FOF52_RS05110	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FOF52_RS05115	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FOF52_RS05120	COG4521	taurine ABC transporter
FOF52_RS05130	COG1309	transcriptional regulator
FOF52_RS05150	COG0596	Alpha beta hydrolase
FOF52_RS05160	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
FOF52_RS05160	COG2169	Transcriptional regulator
FOF52_RS05170	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
FOF52_RS05195	COG0789	Transcriptional regulator
FOF52_RS05200	COG1960	acyl-CoA dehydrogenase activity
FOF52_RS05205	COG0789	Transcriptional regulator
FOF52_RS05210	COG2030	dehydratase
FOF52_RS05215	COG0446	pyridine nucleotide-disulphide oxidoreductase
FOF52_RS05215	COG1902	pentaerythritol trinitrate reductase activity
FOF52_RS05225	COG1053	succinate dehydrogenase
FOF52_RS05235	COG0028	Belongs to the TPP enzyme family
FOF52_RS05240	COG1053	succinate dehydrogenase
FOF52_RS05250	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
FOF52_RS05310	COG1024	Enoyl-CoA hydratase
FOF52_RS05315	COG1250	3-hydroxyacyl-CoA dehydrogenase
FOF52_RS05325	COG1028	Short-chain dehydrogenase reductase Sdr
FOF52_RS05335	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
FOF52_RS05340	COG1024	Enoyl-CoA hydratase
FOF52_RS05345	COG1703	isobutyryl-CoA mutase activity
FOF52_RS05350	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
FOF52_RS05350	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
FOF52_RS05360	COG1028	Short-chain dehydrogenase reductase Sdr
FOF52_RS05375	COG1960	acyl-CoA dehydrogenase activity
FOF52_RS05380	COG0318	PFAM AMP-dependent synthetase and ligase
FOF52_RS05385	COG0318	PFAM AMP-dependent synthetase and ligase
FOF52_RS05390	COG1024	Enoyl-CoA hydratase
FOF52_RS05425	COG0183	Belongs to the thiolase family
FOF52_RS05430	COG1024	Enoyl-CoA hydratase
FOF52_RS05455	COG1053	succinate dehydrogenase
FOF52_RS05455	COG3976	FMN-binding domain protein
FOF52_RS05465	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FOF52_RS05480	COG0515	serine threonine protein kinase
FOF52_RS05480	COG2815	serine threonine protein kinase
FOF52_RS05490	COG2233	PERMEase
FOF52_RS05520	COG0318	PFAM AMP-dependent synthetase and ligase
FOF52_RS05525	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
FOF52_RS05540	COG1960	acyl-CoA dehydrogenase activity
FOF52_RS05560	COG1960	acyl-CoA dehydrogenase activity
FOF52_RS05570	COG1960	acyl-CoA dehydrogenase activity
FOF52_RS05580	COG1804	L-carnitine dehydratase bile acid-inducible protein F
FOF52_RS05585	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
FOF52_RS05605	COG0318	PFAM AMP-dependent synthetase and ligase
FOF52_RS05610	COG1028	Short-chain dehydrogenase reductase Sdr
FOF52_RS05625	COG1024	Enoyl-CoA hydratase
FOF52_RS05635	COG0318	PFAM AMP-dependent synthetase and ligase
FOF52_RS05665	COG1024	Enoyl-CoA hydratase
FOF52_RS05670	COG1028	Short-chain dehydrogenase reductase Sdr
FOF52_RS05675	COG0183	Belongs to the thiolase family
FOF52_RS05695	COG0492	ferredoxin-NADP+ reductase activity
FOF52_RS05715	COG0252	asparaginase activity
FOF52_RS05720	COG1770	oligopeptidase
FOF52_RS05730	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
FOF52_RS05730	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
FOF52_RS05755	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
FOF52_RS05755	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
FOF52_RS05780	COG1595	DNA-templated transcription, initiation
FOF52_RS05795	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
FOF52_RS05800	COG1234	tRNA 3'-trailer cleavage
FOF52_RS05810	COG0071	Belongs to the small heat shock protein (HSP20) family
FOF52_RS05890	COG4974	Belongs to the 'phage' integrase family
FOF52_RS05910	COG1846	Transcriptional regulator
FOF52_RS05915	COG1228	amidohydrolase
FOF52_RS05930	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
FOF52_RS06030	COG0640	Transcriptional regulator
FOF52_RS06040	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
FOF52_RS06060	COG0583	DNA-binding transcription factor activity
FOF52_RS06080	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
FOF52_RS06105	COG3189	MarR family transcriptional regulator
FOF52_RS06145	COG2885	chlorophyll binding
FOF52_RS06145	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
FOF52_RS06165	COG3629	intracellular signal transduction
FOF52_RS06165	COG3903	Transcriptional regulator
FOF52_RS06170	COG2197	response regulator
FOF52_RS06175	COG4585	Histidine kinase
FOF52_RS06225	COG2323	membrane
FOF52_RS06245	COG0798	PFAM Bile acid sodium symporter
FOF52_RS06250	COG1064	alcohol dehydrogenase
FOF52_RS06270	COG0574	Belongs to the PEP-utilizing enzyme family
FOF52_RS06270	COG3848	Pyruvate phosphate dikinase
FOF52_RS06275	COG0488	(ABC) transporter
FOF52_RS06295	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
FOF52_RS06350	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FOF52_RS06375	COG4941	Belongs to the sigma-70 factor family
FOF52_RS06380	COG3795	YCII-related domain
FOF52_RS06385	COG1960	acyl-CoA dehydrogenase activity
FOF52_RS06430	COG1434	Gram-negative-bacterium-type cell wall biogenesis
FOF52_RS06495	COG1131	(ABC) transporter
FOF52_RS06535	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
FOF52_RS06580	COG0477	Major facilitator Superfamily
FOF52_RS06610	COG0640	Transcriptional regulator
FOF52_RS06615	COG0346	lactoylglutathione lyase activity
FOF52_RS06630	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
FOF52_RS06635	COG1518	maintenance of DNA repeat elements
FOF52_RS06695	COG3467	pyridoxamine 5'-phosphate
FOF52_RS06705	COG1595	DNA-templated transcription, initiation
FOF52_RS06710	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
FOF52_RS06730	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
FOF52_RS06730	COG0574	Belongs to the PEP-utilizing enzyme family
FOF52_RS06770	COG1028	Short-chain dehydrogenase reductase Sdr
FOF52_RS06775	COG1136	(ABC) transporter
FOF52_RS06775	COG0577	efflux transmembrane transporter activity
FOF52_RS06785	COG1028	Short-chain dehydrogenase reductase Sdr
FOF52_RS06810	COG1070	Carbohydrate kinase
FOF52_RS06850	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
FOF52_RS06900	COG1472	Belongs to the glycosyl hydrolase 3 family
FOF52_RS06905	COG1940	carbohydrate kinase activity
FOF52_RS06915	COG4209	transmembrane transport
FOF52_RS06920	COG0395	ABC-type sugar transport system, permease component
FOF52_RS06930	COG1131	(ABC) transporter
FOF52_RS06955	COG1136	(ABC) transporter
FOF52_RS06955	COG0577	efflux transmembrane transporter activity
FOF52_RS06960	COG0657	acetylesterase activity
FOF52_RS06975	COG4585	Histidine kinase
FOF52_RS06980	COG2197	response regulator
FOF52_RS06995	COG0500	methyltransferase
FOF52_RS07000	COG3321	synthase
FOF52_RS07000	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
FOF52_RS07040	COG1501	Belongs to the glycosyl hydrolase 31 family
FOF52_RS07070	COG1175	transmembrane transport
FOF52_RS07075	COG1653	transport
FOF52_RS07085	COG1396	sequence-specific DNA binding
FOF52_RS07090	COG0740	serine-type endopeptidase activity
FOF52_RS07095	COG0726	polysaccharide deacetylase
FOF52_RS07100	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FOF52_RS07115	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
FOF52_RS07130	COG5006	permease, DMT superfamily
FOF52_RS07145	COG2855	membrane
FOF52_RS07175	COG0601	transmembrane transport
FOF52_RS07180	COG4166	transmembrane transport
FOF52_RS07200	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
FOF52_RS07210	COG1028	Short-chain dehydrogenase reductase Sdr
FOF52_RS07240	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FOF52_RS07290	COG1028	Short-chain dehydrogenase reductase Sdr
FOF52_RS07295	COG2323	membrane
FOF52_RS07305	COG1090	epimerase
FOF52_RS07315	COG2267	carboxylic ester hydrolase activity
FOF52_RS07325	COG1028	Short-chain dehydrogenase reductase Sdr
FOF52_RS07380	COG4221	oxidoreductase activity
FOF52_RS07395	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
FOF52_RS07400	COG0243	molybdopterin cofactor binding
FOF52_RS07420	COG3629	intracellular signal transduction
FOF52_RS07420	COG3903	Transcriptional regulator
FOF52_RS07445	COG1819	glycosyl
FOF52_RS07450	COG2124	cytochrome p450
FOF52_RS07455	COG0702	epimerase
FOF52_RS07500	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
FOF52_RS07510	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
FOF52_RS07530	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
FOF52_RS07555	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FOF52_RS07570	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
FOF52_RS07575	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
FOF52_RS07600	COG1819	glycosyl
FOF52_RS07640	COG0579	oxidoreductase
FOF52_RS07660	COG1108	ABC-type Mn2 Zn2 transport systems permease components
FOF52_RS07665	COG1121	(ABC) transporter
FOF52_RS07685	COG0512	Glutamine amidotransferase of anthranilate synthase
FOF52_RS07685	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
FOF52_RS07690	COG0789	Transcriptional regulator
FOF52_RS07695	COG0659	secondary active sulfate transmembrane transporter activity
FOF52_RS07700	COG0477	Major facilitator Superfamily
FOF52_RS07705	COG1252	NADH dehydrogenase
FOF52_RS07710	COG1595	DNA-templated transcription, initiation
FOF52_RS07735	COG2226	methyltransferase
FOF52_RS07740	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FOF52_RS07745	COG4106	trans-aconitate 2-methyltransferase activity
FOF52_RS07755	COG3540	Alkaline phosphatase
FOF52_RS07760	COG0667	Aldo Keto reductase
FOF52_RS07770	COG0714	Associated with various cellular activities
FOF52_RS07780	COG2304	oxidoreductase activity
FOF52_RS07785	COG0546	phosphoglycolate phosphatase activity
FOF52_RS07790	COG1051	belongs to the nudix hydrolase family
FOF52_RS07800	COG1028	Short-chain dehydrogenase reductase Sdr
FOF52_RS07805	COG2813	Specifically methylates the guanine in position
FOF52_RS07810	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
FOF52_RS07815	COG1253	flavin adenine dinucleotide binding
FOF52_RS07820	COG1253	flavin adenine dinucleotide binding
FOF52_RS07835	COG1012	belongs to the aldehyde dehydrogenase family
FOF52_RS07860	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FOF52_RS07865	COG0730	response to heat
FOF52_RS07870	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
FOF52_RS07875	COG0028	Belongs to the TPP enzyme family
FOF52_RS07915	COG1132	(ABC) transporter
FOF52_RS07925	COG2072	flavoprotein involved in K transport
FOF52_RS07935	COG1028	Short-chain dehydrogenase reductase Sdr
FOF52_RS07940	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
FOF52_RS07940	COG2755	lipolytic protein G-D-S-L family
FOF52_RS07945	COG1653	transport
FOF52_RS07950	COG0395	ABC-type sugar transport system, permease component
FOF52_RS07955	COG1175	transmembrane transport
FOF52_RS07960	COG0673	inositol 2-dehydrogenase activity
FOF52_RS08000	COG2188	Transcriptional regulator
FOF52_RS08020	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FOF52_RS08025	COG2376	Dihydroxyacetone kinase
FOF52_RS08035	COG0723	plastoquinol--plastocyanin reductase activity
FOF52_RS08035	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FOF52_RS08040	COG4948	Mandelate Racemase Muconate Lactonizing
FOF52_RS08045	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FOF52_RS08060	COG0673	inositol 2-dehydrogenase activity
FOF52_RS08075	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
FOF52_RS08100	COG0789	Transcriptional regulator
FOF52_RS08125	COG0242	peptide deformylase activity
FOF52_RS08135	COG2814	Major facilitator Superfamily
FOF52_RS08140	COG0463	Glycosyl transferase, family 2
FOF52_RS08150	COG0463	Glycosyl transferase, family 2
FOF52_RS08160	COG1022	Amp-dependent synthetase and ligase
FOF52_RS08170	COG2814	Major facilitator Superfamily
FOF52_RS08190	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
FOF52_RS08205	COG1278	Cold shock
FOF52_RS08220	COG0583	DNA-binding transcription factor activity
FOF52_RS08225	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
FOF52_RS08230	COG1442	glycosyl transferase family 8
FOF52_RS08230	COG1216	Glycosyl transferase, family 2
FOF52_RS08240	COG0006	proline dipeptidase activity
FOF52_RS08280	COG2124	cytochrome p450
FOF52_RS08310	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
FOF52_RS08320	COG1120	ATPase activity
FOF52_RS08325	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FOF52_RS08345	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
FOF52_RS08350	COG2226	methyltransferase
FOF52_RS08360	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
FOF52_RS08375	COG2378	regulation of single-species biofilm formation
FOF52_RS08380	COG3739	integral membrane protein
FOF52_RS08405	COG2124	cytochrome p450
FOF52_RS08420	COG3655	Transcriptional regulator
FOF52_RS08465	COG0438	transferase activity, transferring glycosyl groups
FOF52_RS08470	COG0366	Alpha amylase catalytic
FOF52_RS08475	COG2197	response regulator
FOF52_RS08480	COG4585	Histidine kinase
FOF52_RS08495	COG4581	dead DEAH box helicase
FOF52_RS08510	COG0805	protein transport
FOF52_RS08550	COG1960	acyl-CoA dehydrogenase activity
FOF52_RS08595	COG2186	Transcriptional regulator
FOF52_RS08600	COG4948	Mandelate Racemase Muconate Lactonizing
FOF52_RS08610	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
FOF52_RS08615	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
FOF52_RS08620	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
FOF52_RS08640	COG0477	Major facilitator Superfamily
FOF52_RS08650	COG4122	O-methyltransferase activity
FOF52_RS08660	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
FOF52_RS08670	COG1222	aaa ATPase
FOF52_RS08700	COG0517	IMP dehydrogenase activity
FOF52_RS08700	COG1994	Peptidase M50
FOF52_RS08710	COG2197	response regulator
FOF52_RS08750	COG0646	methionine synthase
FOF52_RS08750	COG1410	methionine synthase
FOF52_RS08770	COG0326	Molecular chaperone. Has ATPase activity
FOF52_RS08775	COG0215	cysteine-tRNA ligase activity
FOF52_RS08790	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
FOF52_RS08805	COG0406	alpha-ribazole phosphatase activity
FOF52_RS08810	COG1968	undecaprenyl-diphosphatase activity
FOF52_RS08815	COG0667	Aldo Keto reductase
FOF52_RS08830	COG1028	Short-chain dehydrogenase reductase Sdr
FOF52_RS08840	COG1028	Short-chain dehydrogenase reductase Sdr
FOF52_RS08850	COG3173	Aminoglycoside phosphotransferase
FOF52_RS08865	COG2197	response regulator
FOF52_RS08870	COG4585	Histidine kinase
FOF52_RS08875	COG1136	(ABC) transporter
FOF52_RS08875	COG0577	efflux transmembrane transporter activity
FOF52_RS08880	COG0577	efflux transmembrane transporter activity
FOF52_RS08880	COG1136	(ABC) transporter
FOF52_RS08915	COG1349	DNA-binding transcription factor activity
FOF52_RS08920	COG2091	lysine biosynthetic process via aminoadipic acid
FOF52_RS08925	COG1505	serine-type exopeptidase activity
FOF52_RS08975	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
FOF52_RS08985	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
FOF52_RS08990	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
FOF52_RS09000	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
FOF52_RS09020	COG3433	isochorismatase activity
FOF52_RS09020	COG1535	isochorismatase
FOF52_RS09035	COG1021	2,3-dihydroxybenzoate-AMP ligase
FOF52_RS09040	COG1169	isochorismate synthase
FOF52_RS09045	COG1028	Short-chain dehydrogenase reductase Sdr
FOF52_RS09055	COG0701	Predicted permease
FOF52_RS09060	COG2130	NADP-dependent
FOF52_RS09070	COG1733	regulation of RNA biosynthetic process
FOF52_RS09095	COG0488	(ABC) transporter
FOF52_RS09140	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
FOF52_RS09150	COG0175	sulfate reduction
FOF52_RS09160	COG1309	transcriptional regulator
FOF52_RS09170	COG1960	acyl-CoA dehydrogenase activity
FOF52_RS09185	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FOF52_RS09190	COG0688	phosphatidylethanolamine metabolic process
FOF52_RS09200	COG3253	May function as heme-dependent peroxidase
FOF52_RS09205	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
FOF52_RS09215	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
FOF52_RS09235	COG0183	Belongs to the thiolase family
FOF52_RS09260	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
FOF52_RS09270	COG2409	Drug exporters of the RND superfamily
FOF52_RS09290	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
FOF52_RS09305	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
FOF52_RS09310	COG3663	DNA glycosylase
FOF52_RS09320	COG4214	carbohydrate transport
FOF52_RS09330	COG4213	ABC transporter substrate-binding protein
FOF52_RS09335	COG1940	carbohydrate kinase activity
FOF52_RS09345	COG1595	DNA-templated transcription, initiation
FOF52_RS09350	COG1595	DNA-templated transcription, initiation
FOF52_RS09365	COG4607	ABC-type enterochelin transport system periplasmic component
FOF52_RS09370	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FOF52_RS09375	COG4605	iron ion homeostasis
FOF52_RS09380	COG4604	ABC transporter, ATP-binding protein
FOF52_RS09395	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
FOF52_RS09400	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FOF52_RS09405	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
FOF52_RS09410	COG0569	domain protein
FOF52_RS09420	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
FOF52_RS09450	COG0756	dUTP diphosphatase activity
FOF52_RS09455	COG0525	valine-tRNA ligase activity
FOF52_RS09475	COG2205	protein histidine kinase activity
FOF52_RS09480	COG0745	RESPONSE REGULATOR receiver
FOF52_RS09500	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
FOF52_RS09555	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
FOF52_RS09565	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
FOF52_RS09580	COG4733	cellulase activity
FOF52_RS09580	COG5297	Belongs to the glycosyl hydrolase family 6
FOF52_RS09590	COG0009	L-threonylcarbamoyladenylate synthase
FOF52_RS09600	COG2318	DinB family
FOF52_RS09605	COG2813	Specifically methylates the guanine in position
FOF52_RS09610	COG1396	sequence-specific DNA binding
FOF52_RS09650	COG0432	Pfam Uncharacterised protein family UPF0047
FOF52_RS09660	COG1984	allophanate hydrolase subunit 2
FOF52_RS09665	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
FOF52_RS09670	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
FOF52_RS09690	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
FOF52_RS09695	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FOF52_RS09700	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
FOF52_RS09710	COG2755	lipolytic protein G-D-S-L family
FOF52_RS09725	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FOF52_RS09735	COG2151	metal-sulfur cluster biosynthetic enzyme
FOF52_RS09750	COG0396	ATPase activity
FOF52_RS09775	COG1131	(ABC) transporter
FOF52_RS09795	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
FOF52_RS09800	COG2235	arginine
FOF52_RS09815	COG3311	Transcriptional regulator
FOF52_RS09835	COG0318	PFAM AMP-dependent synthetase and ligase
FOF52_RS09840	COG1960	acyl-CoA dehydrogenase activity
FOF52_RS09855	COG0109	protoheme IX farnesyltransferase activity
FOF52_RS09865	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
FOF52_RS09870	COG0166	Belongs to the GPI family
FOF52_RS09885	COG0363	glucosamine-6-phosphate deaminase activity
FOF52_RS09895	COG3401	FG-GAP repeat protein
FOF52_RS09910	COG0531	amino acid
FOF52_RS09925	COG0400	carboxylic ester hydrolase activity
FOF52_RS09930	COG0346	lactoylglutathione lyase activity
FOF52_RS09940	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
FOF52_RS09945	COG0149	triose-phosphate isomerase activity
FOF52_RS09950	COG0126	phosphoglycerate kinase activity
FOF52_RS09955	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
FOF52_RS09960	COG1481	regulation of sporulation
FOF52_RS09970	COG1660	Displays ATPase and GTPase activities
FOF52_RS09975	COG0322	excinuclease ABC activity
FOF52_RS09995	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
FOF52_RS10030	COG0497	DNA recombination
FOF52_RS10035	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
FOF52_RS10065	COG0647	UMP catabolic process
FOF52_RS10110	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
FOF52_RS10160	COG2205	protein histidine kinase activity
FOF52_RS10165	COG0165	Argininosuccinate lyase
FOF52_RS10170	COG0137	argininosuccinate synthase activity
FOF52_RS10175	COG1438	arginine binding
FOF52_RS10180	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
FOF52_RS10185	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
FOF52_RS10190	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
FOF52_RS10195	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
FOF52_RS10200	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
FOF52_RS10205	COG1846	Transcriptional regulator
FOF52_RS10215	COG0745	RESPONSE REGULATOR receiver
FOF52_RS10220	COG2205	protein histidine kinase activity
FOF52_RS10230	COG0072	phenylalanine-tRNA ligase activity
FOF52_RS10230	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FOF52_RS10235	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
FOF52_RS10240	COG5002	protein histidine kinase activity
FOF52_RS10245	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
FOF52_RS10250	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
FOF52_RS10255	COG0291	Belongs to the bacterial ribosomal protein bL35 family
FOF52_RS10260	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
FOF52_RS10265	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
FOF52_RS10275	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
FOF52_RS10280	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
FOF52_RS10285	COG1434	Gram-negative-bacterium-type cell wall biogenesis
FOF52_RS10290	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
FOF52_RS10340	COG0515	serine threonine protein kinase
FOF52_RS10340	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
FOF52_RS10395	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
FOF52_RS10405	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
FOF52_RS10415	COG1196	nuclear chromosome segregation
FOF52_RS10425	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
FOF52_RS10430	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
FOF52_RS10435	COG1862	Preprotein translocase
FOF52_RS10440	COG2255	four-way junction helicase activity
FOF52_RS10445	COG0632	four-way junction helicase activity
FOF52_RS10450	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
FOF52_RS10455	COG0217	transcriptional regulatory protein
FOF52_RS10460	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
FOF52_RS10465	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
FOF52_RS10475	COG0438	transferase activity, transferring glycosyl groups
FOF52_RS10480	COG1560	Kdo2-lipid A biosynthetic process
FOF52_RS10485	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
FOF52_RS10510	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
FOF52_RS10565	COG3265	gluconokinase activity
FOF52_RS10595	COG1011	Hydrolase
FOF52_RS10635	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FOF52_RS10650	COG0045	succinate-CoA ligase (ADP-forming) activity
FOF52_RS10660	COG0514	ATP-dependent DNA helicase (RecQ)
FOF52_RS10670	COG1320	monovalent cation:proton antiporter activity
FOF52_RS10675	COG2212	antiporter activity
FOF52_RS10685	COG0651	ATP synthesis coupled electron transport
FOF52_RS10690	COG1006	Multisubunit Na H antiporter MnhC subunit
FOF52_RS10695	COG2111	Na H antiporter
FOF52_RS10700	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
FOF52_RS10700	COG2111	Na H antiporter
FOF52_RS10705	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
FOF52_RS10720	COG0187	DNA topoisomerase II activity
FOF52_RS10735	COG3022	response to hydroperoxide
FOF52_RS10750	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
FOF52_RS10750	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
FOF52_RS10775	COG0464	growth
FOF52_RS10780	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
FOF52_RS10800	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
FOF52_RS10805	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
FOF52_RS10810	COG1388	LysM domain
FOF52_RS10815	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
FOF52_RS10835	COG0495	leucyl-tRNA aminoacylation
FOF52_RS10845	COG0318	PFAM AMP-dependent synthetase and ligase
FOF52_RS10850	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
FOF52_RS10865	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
FOF52_RS10875	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
FOF52_RS10935	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
FOF52_RS10940	COG0501	Belongs to the peptidase M48B family
FOF52_RS10960	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
FOF52_RS10970	COG0438	transferase activity, transferring glycosyl groups
FOF52_RS10975	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
FOF52_RS10980	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
FOF52_RS10985	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
FOF52_RS10990	COG0211	Belongs to the bacterial ribosomal protein bL27 family
FOF52_RS10995	COG0261	This protein binds to 23S rRNA in the presence of protein L20
FOF52_RS11000	COG1530	ribonuclease E activity
FOF52_RS11015	COG0772	Belongs to the SEDS family
FOF52_RS11025	COG0105	UTP biosynthetic process
FOF52_RS11035	COG0285	dihydrofolate synthase activity
FOF52_RS11045	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
FOF52_RS11050	COG0740	serine-type endopeptidase activity
FOF52_RS11055	COG0740	serine-type endopeptidase activity
FOF52_RS11060	COG0544	peptidyl-prolyl cis-trans isomerase activity
FOF52_RS11075	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
FOF52_RS11075	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
FOF52_RS11080	COG1132	(ABC) transporter
FOF52_RS11090	COG2239	Acts as a magnesium transporter
FOF52_RS11100	COG4552	Acetyltransferase involved in intracellular survival and related
FOF52_RS11105	COG0698	ribose 5-phosphate isomerase
FOF52_RS11120	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
FOF52_RS11150	COG0129	dihydroxy-acid dehydratase activity
FOF52_RS11165	COG1505	serine-type exopeptidase activity
FOF52_RS11175	COG2271	Major facilitator Superfamily
FOF52_RS11200	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
FOF52_RS11210	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
FOF52_RS11210	COG1648	precorrin-2 dehydrogenase activity
FOF52_RS11215	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
FOF52_RS11240	COG0515	serine threonine protein kinase
FOF52_RS11240	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
FOF52_RS11265	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
FOF52_RS11285	COG4585	Histidine kinase
FOF52_RS11290	COG2197	response regulator
FOF52_RS11295	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
FOF52_RS11300	COG3766	membrane
FOF52_RS11325	COG1522	sequence-specific DNA binding
FOF52_RS11350	COG0477	Major facilitator Superfamily
FOF52_RS11360	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
FOF52_RS11365	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FOF52_RS11380	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
FOF52_RS11405	COG1115	amino acid carrier protein
FOF52_RS11420	COG0436	Aminotransferase
FOF52_RS11425	COG0583	DNA-binding transcription factor activity
FOF52_RS11440	COG0438	transferase activity, transferring glycosyl groups
FOF52_RS11450	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
FOF52_RS11475	COG1597	lipid kinase activity
FOF52_RS11505	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
FOF52_RS11525	COG2894	cell division
FOF52_RS11550	COG4585	Histidine kinase
FOF52_RS11555	COG2197	response regulator
FOF52_RS11580	COG0741	lytic transglycosylase activity
FOF52_RS11580	COG0791	NLP P60 protein
FOF52_RS11615	COG0667	Aldo Keto reductase
FOF52_RS11635	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FOF52_RS11660	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
FOF52_RS11665	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
FOF52_RS11670	COG0569	domain protein
FOF52_RS11700	COG1960	acyl-CoA dehydrogenase activity
FOF52_RS11705	COG1960	acyl-CoA dehydrogenase activity
FOF52_RS11715	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
FOF52_RS11720	COG1122	ATPase activity
FOF52_RS11725	COG1268	BioY protein
FOF52_RS11730	COG2706	6-phosphogluconolactonase activity
FOF52_RS11750	COG2018	Roadblock/LC7 domain
FOF52_RS11760	COG1643	Atp-dependent helicase
FOF52_RS11815	COG1737	Transcriptional regulator
FOF52_RS11820	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
FOF52_RS11825	COG2949	membrane
FOF52_RS11865	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
FOF52_RS11930	COG3395	kinase activity
FOF52_RS11935	COG0673	inositol 2-dehydrogenase activity
FOF52_RS11940	COG1653	transport
FOF52_RS11945	COG1175	transmembrane transport
FOF52_RS11950	COG0395	ABC-type sugar transport system, permease component
FOF52_RS11960	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
FOF52_RS11965	COG0784	Response regulator, receiver
FOF52_RS11970	COG4251	negative regulation of phosphorylation
FOF52_RS11980	COG5398	heme oxygenase
FOF52_RS11995	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
FOF52_RS12005	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
FOF52_RS12010	COG0404	The glycine cleavage system catalyzes the degradation of glycine
FOF52_RS12015	COG0509	glycine decarboxylation via glycine cleavage system
FOF52_RS12020	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
FOF52_RS12060	COG0515	serine threonine protein kinase
FOF52_RS12060	COG2815	serine threonine protein kinase
FOF52_RS12070	COG1025	Belongs to the peptidase M16 family
FOF52_RS12090	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
FOF52_RS12095	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
FOF52_RS12130	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
FOF52_RS12140	COG1335	isochorismatase
FOF52_RS12155	COG0515	serine threonine protein kinase
FOF52_RS12155	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
FOF52_RS12195	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
FOF52_RS12200	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FOF52_RS12220	COG1678	Uncharacterized ACR, COG1678
FOF52_RS12245	COG0183	Belongs to the thiolase family
FOF52_RS12270	COG1250	3-hydroxyacyl-CoA dehydrogenase
FOF52_RS12280	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
FOF52_RS12315	COG0355	proton-transporting ATP synthase activity, rotational mechanism
FOF52_RS12320	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
FOF52_RS12325	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
FOF52_RS12330	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
FOF52_RS12335	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
FOF52_RS12340	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
FOF52_RS12345	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
FOF52_RS12365	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
FOF52_RS12375	COG2890	protein-(glutamine-N5) methyltransferase activity
FOF52_RS12380	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
FOF52_RS12385	COG0254	rRNA binding
FOF52_RS12395	COG0083	homoserine kinase activity
FOF52_RS12400	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
FOF52_RS12405	COG0460	homoserine dehydrogenase
FOF52_RS12410	COG0019	diaminopimelate decarboxylase activity
FOF52_RS12430	COG2272	Belongs to the type-B carboxylesterase lipase family
FOF52_RS12460	COG0242	peptide deformylase activity
FOF52_RS12490	COG3594	Acyltransferase
FOF52_RS12550	COG1061	Type III restriction enzyme res subunit
FOF52_RS12555	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
FOF52_RS12560	COG1053	succinate dehydrogenase
FOF52_RS12575	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FOF52_RS12580	COG1217	gtp-binding protein TYPA
FOF52_RS12585	COG0494	nUDIX hydrolase
FOF52_RS12620	COG2226	methyltransferase
FOF52_RS12625	COG0500	methyltransferase
FOF52_RS12635	COG4981	capsule polysaccharide biosynthetic process
FOF52_RS12725	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
FOF52_RS12730	COG2177	Part of the ABC transporter FtsEX involved in
FOF52_RS12735	COG2884	Cell division ATP-binding protein ftsE
FOF52_RS12740	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
FOF52_RS12750	COG2902	Dehydrogenase
FOF52_RS12770	COG1011	Hydrolase
FOF52_RS12775	COG1960	acyl-CoA dehydrogenase activity
FOF52_RS12780	COG1472	Belongs to the glycosyl hydrolase 3 family
FOF52_RS12785	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
FOF52_RS12800	COG0653	protein targeting
FOF52_RS12805	COG2197	response regulator
FOF52_RS12810	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
FOF52_RS12820	COG5401	PFAM Sporulation and spore germination
FOF52_RS12825	COG5002	protein histidine kinase activity
FOF52_RS12825	COG5000	phosphorelay sensor kinase activity
FOF52_RS12830	COG0745	RESPONSE REGULATOR receiver
FOF52_RS12850	COG0714	Associated with various cellular activities
FOF52_RS12875	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
FOF52_RS12895	COG2835	tetraacyldisaccharide 4'-kinase activity
FOF52_RS12935	COG0391	Required for morphogenesis under gluconeogenic growth conditions
FOF52_RS12940	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
FOF52_RS12940	COG0778	Nitroreductase
FOF52_RS12945	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
FOF52_RS12950	COG2226	methyltransferase
FOF52_RS12980	COG1316	TRANSCRIPTIONal
FOF52_RS13000	COG0778	Nitroreductase
FOF52_RS13035	COG1134	teichoic acid transport
FOF52_RS13045	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
FOF52_RS13060	COG1316	TRANSCRIPTIONal
FOF52_RS13070	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
FOF52_RS13075	COG1832	CoA-binding protein
FOF52_RS13100	COG0745	RESPONSE REGULATOR receiver
FOF52_RS13105	COG5002	protein histidine kinase activity
FOF52_RS13115	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
FOF52_RS13125	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
FOF52_RS13130	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
FOF52_RS13140	COG4770	biotin carboxylase activity
FOF52_RS13200	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
FOF52_RS13205	COG1473	amidohydrolase
FOF52_RS13205	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
FOF52_RS13210	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
FOF52_RS13220	COG1316	TRANSCRIPTIONal
FOF52_RS13240	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
FOF52_RS13245	COG0138	bifunctional purine biosynthesis protein purh
FOF52_RS13270	COG0045	succinate-CoA ligase (ADP-forming) activity
FOF52_RS13305	COG1957	nucleoside hydrolase
FOF52_RS13310	COG2197	response regulator
FOF52_RS13315	COG4585	Histidine kinase
FOF52_RS13350	COG0518	GMP synthase (glutamine-hydrolyzing) activity
FOF52_RS13350	COG0519	Catalyzes the synthesis of GMP from XMP
FOF52_RS13355	COG1012	belongs to the aldehyde dehydrogenase family
FOF52_RS13370	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
FOF52_RS13385	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
FOF52_RS13395	COG0516	GMP reductase activity
FOF52_RS13405	COG1595	DNA-templated transcription, initiation
FOF52_RS13410	COG0459	protein refolding
FOF52_RS13415	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
FOF52_RS13440	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
FOF52_RS13445	COG1247	-acetyltransferase
FOF52_RS13455	COG0802	atpase or kinase
FOF52_RS13460	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
FOF52_RS13485	COG1072	(Pantothenic acid kinase))
FOF52_RS13495	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
FOF52_RS13505	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
FOF52_RS13510	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
FOF52_RS13515	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
FOF52_RS13525	COG0101	tRNA pseudouridine synthase activity
FOF52_RS13530	COG0203	ribosomal protein L17
FOF52_RS13535	COG0202	RNA polymerase activity
FOF52_RS13540	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
FOF52_RS13545	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
FOF52_RS13550	COG0257	Belongs to the bacterial ribosomal protein bL36 family
FOF52_RS13555	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
FOF52_RS13565	COG0024	Methionine aminopeptidase
FOF52_RS13570	COG0563	adenylate kinase activity
FOF52_RS13580	COG0200	Binds to the 23S rRNA
FOF52_RS13585	COG1841	ribosomal large subunit assembly
FOF52_RS13590	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
FOF52_RS13595	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
FOF52_RS13600	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
FOF52_RS13605	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
FOF52_RS13610	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
FOF52_RS13615	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
FOF52_RS13620	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
FOF52_RS13625	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
FOF52_RS13630	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
FOF52_RS13635	COG0255	Belongs to the universal ribosomal protein uL29 family
FOF52_RS13640	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
FOF52_RS13645	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
FOF52_RS13650	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
FOF52_RS13655	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
FOF52_RS13660	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
FOF52_RS13665	COG0089	rRNA binding
FOF52_RS13670	COG0088	Forms part of the polypeptide exit tunnel
FOF52_RS13675	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
FOF52_RS13680	COG0051	transcription antitermination factor activity, RNA binding
FOF52_RS13685	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
FOF52_RS13690	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
FOF52_RS13695	COG0049	tRNA binding
FOF52_RS13700	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
FOF52_RS13710	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
FOF52_RS13715	COG0085	RNA polymerase activity
FOF52_RS13720	COG0222	ribosome binding
FOF52_RS13725	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
FOF52_RS13735	COG0081	regulation of translation
FOF52_RS13740	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
FOF52_RS13750	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
FOF52_RS13760	COG0436	Aminotransferase
FOF52_RS13765	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
FOF52_RS13770	COG2119	membrane
FOF52_RS13775	COG0812	UDP-N-acetylmuramate dehydrogenase activity
FOF52_RS13785	COG2030	dehydratase
FOF52_RS13790	COG0267	Belongs to the bacterial ribosomal protein bL33 family
FOF52_RS13805	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
FOF52_RS13835	COG1666	GTP binding
FOF52_RS13840	COG0501	Belongs to the peptidase M48B family
FOF52_RS13845	COG0674	pyruvate-flavodoxin oxidoreductase activity
FOF52_RS13845	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
FOF52_RS13850	COG1013	pyruvate-flavodoxin oxidoreductase activity
FOF52_RS13855	COG0702	epimerase
FOF52_RS13865	COG0456	acetyltransferase
FOF52_RS13885	COG1595	DNA-templated transcription, initiation
FOF52_RS13895	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FOF52_RS13905	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
FOF52_RS13910	COG0142	geranyltranstransferase activity
FOF52_RS13915	COG1007	ATP synthesis coupled electron transport
FOF52_RS13930	COG0713	ATP synthesis coupled electron transport
FOF52_RS13940	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FOF52_RS13945	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
FOF52_RS13950	COG1034	ATP synthesis coupled electron transport
FOF52_RS13955	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
FOF52_RS13965	COG0649	NAD binding
FOF52_RS13970	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FOF52_RS13975	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FOF52_RS13990	COG2226	methyltransferase
FOF52_RS14010	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
FOF52_RS14015	COG1333	cytochrome c biogenesis protein
FOF52_RS14020	COG0785	Cytochrome C biogenesis protein
FOF52_RS14025	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
FOF52_RS14040	COG0123	including yeast histone deacetylase and acetoin utilization protein
FOF52_RS14045	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
FOF52_RS14055	COG1082	Xylose isomerase domain protein TIM barrel
FOF52_RS14065	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
FOF52_RS14080	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
FOF52_RS14100	COG2897	thiosulfate sulfurtransferase activity
FOF52_RS14130	COG0406	alpha-ribazole phosphatase activity
FOF52_RS14135	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
FOF52_RS14140	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
FOF52_RS14155	COG0113	porphobilinogen synthase activity
FOF52_RS14165	COG0181	hydroxymethylbilane synthase activity
FOF52_RS14170	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
FOF52_RS14175	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
FOF52_RS14190	COG0745	RESPONSE REGULATOR receiver
FOF52_RS14200	COG0456	acetyltransferase
FOF52_RS14220	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
FOF52_RS14235	COG0306	phosphate transporter
FOF52_RS14240	COG1392	Phosphate transport regulator
FOF52_RS14255	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
FOF52_RS14280	COG0860	N-Acetylmuramoyl-L-alanine amidase
FOF52_RS14290	COG1309	transcriptional regulator
FOF52_RS14300	COG1739	Uncharacterized protein family UPF0029
FOF52_RS14310	COG0386	Belongs to the glutathione peroxidase family
FOF52_RS14340	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
FOF52_RS14365	COG1486	melibiose metabolic process
FOF52_RS14410	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
FOF52_RS14460	COG2188	Transcriptional regulator
FOF52_RS14480	COG0582	viral genome integration into host DNA
FOF52_RS14500	COG1774	PSP1 C-terminal conserved region
FOF52_RS14505	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
FOF52_RS14510	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
FOF52_RS14515	COG1754	DNA topoisomerase type I activity
FOF52_RS14515	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
FOF52_RS14530	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
FOF52_RS14550	COG1609	Transcriptional regulator
FOF52_RS14560	COG3903	Transcriptional regulator
FOF52_RS14560	COG3629	intracellular signal transduction
FOF52_RS14580	COG0714	Associated with various cellular activities
FOF52_RS14675	COG1132	(ABC) transporter
FOF52_RS14765	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FOF52_RS14770	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
FOF52_RS14770	COG2508	Transcriptional regulator
FOF52_RS14800	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
FOF52_RS14805	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
FOF52_RS14810	COG0142	geranyltranstransferase activity
FOF52_RS14815	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
FOF52_RS14830	COG1028	Short-chain dehydrogenase reductase Sdr
FOF52_RS14885	COG0477	Major facilitator Superfamily
FOF52_RS14925	COG5285	phytanoyl-CoA dioxygenase
FOF52_RS14930	COG2814	Major facilitator Superfamily
FOF52_RS14935	COG1028	Short-chain dehydrogenase reductase Sdr
FOF52_RS14950	COG1024	Enoyl-CoA hydratase
FOF52_RS14960	COG1804	L-carnitine dehydratase bile acid-inducible protein F
FOF52_RS14965	COG1024	Enoyl-CoA hydratase
FOF52_RS14965	COG1250	3-hydroxyacyl-CoA dehydrogenase
FOF52_RS14975	COG4770	biotin carboxylase activity
FOF52_RS14980	COG0183	Belongs to the thiolase family
FOF52_RS14990	COG1137	ATPase activity
FOF52_RS15000	COG0559	Belongs to the binding-protein-dependent transport system permease family
FOF52_RS15025	COG1960	acyl-CoA dehydrogenase activity
FOF52_RS15030	COG0318	PFAM AMP-dependent synthetase and ligase
FOF52_RS15055	COG3119	arylsulfatase activity
FOF52_RS15095	COG2205	protein histidine kinase activity
FOF52_RS15105	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
FOF52_RS15110	COG2197	response regulator
FOF52_RS15120	COG1703	isobutyryl-CoA mutase activity
FOF52_RS15120	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
FOF52_RS15120	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
FOF52_RS15130	COG1063	alcohol dehydrogenase
FOF52_RS15150	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
FOF52_RS15155	COG4260	virion core protein, lumpy skin disease virus
FOF52_RS15180	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
FOF52_RS15185	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
FOF52_RS15205	COG2197	response regulator
FOF52_RS15215	COG1136	(ABC) transporter
FOF52_RS15310	COG1309	transcriptional regulator
FOF52_RS15315	COG2814	Major facilitator Superfamily
FOF52_RS15320	COG0477	Major facilitator Superfamily
FOF52_RS15340	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FOF52_RS15345	COG0247	lactate metabolic process
FOF52_RS15345	COG0277	FAD linked oxidase domain protein
FOF52_RS15355	COG0515	serine threonine protein kinase
FOF52_RS15440	COG1028	Short-chain dehydrogenase reductase Sdr
FOF52_RS15445	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
FOF52_RS15450	COG3275	phosphorelay sensor kinase activity
FOF52_RS15455	COG3279	Response regulator of the LytR AlgR family
FOF52_RS15465	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
FOF52_RS15475	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
FOF52_RS15505	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
FOF52_RS15560	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
FOF52_RS15570	COG0494	nUDIX hydrolase
FOF52_RS15590	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
FOF52_RS15600	COG3226	Transcriptional regulator
FOF52_RS15605	COG0738	Major facilitator superfamily
FOF52_RS15615	COG2226	methyltransferase
FOF52_RS15655	COG3485	protocatechuate 3,4-dioxygenase
FOF52_RS15660	COG0354	folic acid binding
FOF52_RS15700	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
FOF52_RS15710	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
FOF52_RS15715	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
FOF52_RS15720	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
FOF52_RS15725	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
FOF52_RS15755	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
FOF52_RS15760	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
FOF52_RS15770	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
FOF52_RS15775	COG0302	gtp cyclohydrolase
FOF52_RS15785	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
FOF52_RS15790	COG0037	tRNA processing
FOF52_RS15815	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
FOF52_RS15820	COG2027	D-alanyl-D-alanine carboxypeptidase
FOF52_RS15835	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
FOF52_RS15840	COG1329	Transcriptional regulator
FOF52_RS15850	COG5002	protein histidine kinase activity
FOF52_RS15860	COG0588	phosphoglycerate mutase activity
FOF52_RS15870	COG0438	transferase activity, transferring glycosyl groups
FOF52_RS15890	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
FOF52_RS15955	COG1490	D-aminoacyl-tRNA deacylase activity
FOF52_RS15995	COG2113	Glycine betaine
FOF52_RS16000	COG4176	ABC-type proline glycine betaine transport system permease component
FOF52_RS16005	COG3448	diguanylate cyclase activity
FOF52_RS16005	COG4175	Glycine betaine
FOF52_RS16015	COG0717	Belongs to the dCTP deaminase family
FOF52_RS16085	COG0435	Glutathione S-transferase
FOF52_RS16095	COG0702	epimerase
FOF52_RS16100	COG2409	Drug exporters of the RND superfamily
FOF52_RS16110	COG0596	Alpha beta hydrolase
FOF52_RS16110	COG0508	dehydrogenase complex catalyzes the overall conversion of
FOF52_RS16125	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
FOF52_RS16130	COG2197	response regulator
FOF52_RS16135	COG4585	Histidine kinase
FOF52_RS16150	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
FOF52_RS16155	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
FOF52_RS16155	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
FOF52_RS16185	COG1324	tolerance protein
FOF52_RS16190	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
FOF52_RS16210	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
FOF52_RS16215	COG0151	Belongs to the GarS family
FOF52_RS16220	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
FOF52_RS16225	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
FOF52_RS16230	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
FOF52_RS16240	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
FOF52_RS16260	COG1595	DNA-templated transcription, initiation
FOF52_RS16270	COG2124	cytochrome p450
FOF52_RS16275	COG2124	cytochrome p450
FOF52_RS16315	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
FOF52_RS16325	COG1028	Short-chain dehydrogenase reductase Sdr
FOF52_RS16400	COG2197	response regulator
FOF52_RS16415	COG1316	TRANSCRIPTIONal
FOF52_RS16430	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
FOF52_RS16455	COG0582	viral genome integration into host DNA
FOF52_RS16480	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
FOF52_RS16490	COG1609	Transcriptional regulator
FOF52_RS16500	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
FOF52_RS16505	COG3795	YCII-related domain
FOF52_RS16510	COG4941	Belongs to the sigma-70 factor family
FOF52_RS16520	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
FOF52_RS16595	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
FOF52_RS16600	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
FOF52_RS16615	COG0589	response to stress
FOF52_RS16705	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
FOF52_RS16710	COG0022	dehydrogenase e1 component
FOF52_RS16710	COG0508	dehydrogenase complex catalyzes the overall conversion of
FOF52_RS16715	COG0508	dehydrogenase complex catalyzes the overall conversion of
FOF52_RS16730	COG1215	transferase activity, transferring glycosyl groups
FOF52_RS16735	COG1366	Belongs to the anti-sigma-factor antagonist family
FOF52_RS16745	COG5002	protein histidine kinase activity
FOF52_RS16750	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
FOF52_RS16770	COG1716	ATPase activity
FOF52_RS16785	COG0768	penicillin binding
FOF52_RS16790	COG0515	serine threonine protein kinase
FOF52_RS16795	COG0515	serine threonine protein kinase
FOF52_RS16805	COG0705	Rhomboid family
FOF52_RS16860	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
FOF52_RS16880	COG2837	iron assimilation
FOF52_RS16910	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
FOF52_RS16920	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FOF52_RS16950	COG2226	methyltransferase
FOF52_RS16970	COG0359	binds to the 23S rRNA
FOF52_RS16975	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
FOF52_RS16980	COG0629	single-stranded DNA binding
FOF52_RS16985	COG0360	Binds together with S18 to 16S ribosomal RNA
FOF52_RS16995	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
FOF52_RS17050	COG2018	Roadblock/LC7 domain
FOF52_RS17075	COG0515	serine threonine protein kinase
FOF52_RS17075	COG2815	serine threonine protein kinase
FOF52_RS17080	COG1595	DNA-templated transcription, initiation
FOF52_RS17090	COG0492	ferredoxin-NADP+ reductase activity
FOF52_RS17095	COG3118	belongs to the thioredoxin family
FOF52_RS17105	COG1192	Involved in chromosome partitioning
FOF52_RS17110	COG0357	Ribosomal RNA small subunit methyltransferase G
FOF52_RS17115	COG1847	R3H domain protein
FOF52_RS17120	COG0706	membrane insertase activity
FOF52_RS17125	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
FOF52_RS17130	COG0594	ribonuclease P activity
FOF52_RS17135	COG0230	Belongs to the bacterial ribosomal protein bL34 family
FOF52_RS17140	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
FOF52_RS17145	COG0592	DNA-directed DNA polymerase activity
FOF52_RS17150	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
FOF52_RS17155	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
FOF52_RS17160	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
FOF52_RS17165	COG0187	DNA topoisomerase II activity
FOF52_RS17170	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
FOF52_RS17205	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
FOF52_RS17210	COG2089	acid synthase
FOF52_RS17215	COG1216	Glycosyl transferase, family 2
FOF52_RS17225	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
FOF52_RS17225	COG2755	lipolytic protein G-D-S-L family
FOF52_RS17275	COG1482	cell wall glycoprotein biosynthetic process
FOF52_RS17280	COG1316	TRANSCRIPTIONal
FOF52_RS17290	COG0305	Participates in initiation and elongation during chromosome replication
FOF52_RS17310	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
FOF52_RS17335	COG1674	ftsk spoiiie
FOF52_RS17390	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
FOF52_RS17395	COG0583	DNA-binding transcription factor activity
FOF52_RS17405	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
FOF52_RS17460	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
FOF52_RS17465	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
FOF52_RS17475	COG3387	PFAM Glycoside hydrolase 15-related
FOF52_RS17480	COG0587	DNA-directed DNA polymerase activity
FOF52_RS17540	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
FOF52_RS17545	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
FOF52_RS17580	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
FOF52_RS17600	COG4974	Belongs to the 'phage' integrase family
FOF52_RS17710	COG1674	ftsk spoiiie
FOF52_RS17720	COG2259	Doxx family
FOF52_RS17745	COG2183	response to ionizing radiation
FOF52_RS17760	COG4585	Histidine kinase
FOF52_RS17765	COG2197	response regulator
FOF52_RS17800	COG0039	L-malate dehydrogenase activity
FOF52_RS17805	COG0592	DNA-directed DNA polymerase activity
FOF52_RS17850	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
FOF52_RS17860	COG1028	Short-chain dehydrogenase reductase Sdr
FOF52_RS17905	COG3321	synthase
FOF52_RS17905	COG0604	alcohol dehydrogenase
FOF52_RS17905	COG1028	Short-chain dehydrogenase reductase Sdr
FOF52_RS17930	COG1960	acyl-CoA dehydrogenase activity
FOF52_RS17975	COG3903	Transcriptional regulator
FOF52_RS17975	COG3629	intracellular signal transduction
FOF52_RS18000	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
FOF52_RS18040	COG2315	Protein conserved in bacteria
FOF52_RS18050	COG4585	Histidine kinase
FOF52_RS18055	COG2197	response regulator
FOF52_RS18075	COG0488	(ABC) transporter
FOF52_RS18110	COG1063	alcohol dehydrogenase
FOF52_RS18115	COG2208	phosphoserine phosphatase activity
FOF52_RS18120	COG2208	phosphoserine phosphatase activity
FOF52_RS18125	COG1408	metallophosphoesterase
FOF52_RS18135	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
FOF52_RS18170	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FOF52_RS18200	COG1366	Belongs to the anti-sigma-factor antagonist family
FOF52_RS18205	COG1111	helicase
FOF52_RS18205	COG1205	dead DEAH box helicase
FOF52_RS18255	COG0596	Alpha beta hydrolase
FOF52_RS18265	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
FOF52_RS18275	COG0560	Phosphoserine phosphatase
FOF52_RS18275	COG3830	Belongs to the UPF0237 family
FOF52_RS18295	COG1119	ATPase activity
FOF52_RS18310	COG0446	pyridine nucleotide-disulphide oxidoreductase
FOF52_RS18320	COG1309	transcriptional regulator
FOF52_RS18325	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
FOF52_RS18330	COG2843	Capsule synthesis protein
FOF52_RS18375	COG3866	Pectate lyase
FOF52_RS18385	COG0657	acetylesterase activity
FOF52_RS18390	COG0047	phosphoribosylformylglycinamidine synthase activity
FOF52_RS18400	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
FOF52_RS18425	COG4176	ABC-type proline glycine betaine transport system permease component
FOF52_RS18430	COG4175	Glycine betaine
FOF52_RS18440	COG1012	belongs to the aldehyde dehydrogenase family
FOF52_RS18445	COG1476	TRANSCRIPTIONal
FOF52_RS18455	COG1131	(ABC) transporter
FOF52_RS18465	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
FOF52_RS18515	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
FOF52_RS18520	COG1846	Transcriptional regulator
FOF52_RS18535	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
FOF52_RS18540	COG0140	phosphoribosyl-ATP diphosphatase activity
FOF52_RS18545	COG0300	oxidoreductase activity
FOF52_RS18555	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
FOF52_RS18560	COG1595	DNA-templated transcription, initiation
FOF52_RS18570	COG0022	dehydrogenase e1 component
FOF52_RS18575	COG0508	dehydrogenase complex catalyzes the overall conversion of
FOF52_RS18585	COG5002	protein histidine kinase activity
FOF52_RS18585	COG2176	DNA-directed DNA polymerase activity
FOF52_RS18590	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
FOF52_RS18600	COG0706	membrane insertase activity
FOF52_RS18610	COG0181	hydroxymethylbilane synthase activity
FOF52_RS18630	COG0791	NLP P60 protein
FOF52_RS18655	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
FOF52_RS18685	COG2181	nitrate reductase activity
FOF52_RS18685	COG0247	lactate metabolic process
FOF52_RS18690	COG0443	Heat shock 70 kDa protein
FOF52_RS18695	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
FOF52_RS18700	COG0484	heat shock protein binding
FOF52_RS18705	COG0789	Transcriptional regulator
FOF52_RS18710	COG0542	response to heat
FOF52_RS18745	COG1960	acyl-CoA dehydrogenase activity
FOF52_RS18755	COG0215	cysteine-tRNA ligase activity
FOF52_RS18760	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
FOF52_RS18780	COG1404	Belongs to the peptidase S8 family
FOF52_RS18815	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
FOF52_RS18820	COG0459	protein refolding
FOF52_RS18825	COG0494	nUDIX hydrolase
FOF52_RS18855	COG1278	Cold shock
FOF52_RS18880	COG2890	protein-(glutamine-N5) methyltransferase activity
FOF52_RS18890	COG2252	PERMEase
FOF52_RS18900	COG2814	Major facilitator Superfamily
FOF52_RS18905	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
FOF52_RS18920	COG0584	glycerophosphoryl diester phosphodiesterase
FOF52_RS18945	COG0259	pyridoxamine-phosphate oxidase activity
FOF52_RS18955	COG1366	Belongs to the anti-sigma-factor antagonist family
FOF52_RS18955	COG2172	sigma factor antagonist activity
FOF52_RS18955	COG2208	phosphoserine phosphatase activity
FOF52_RS18960	COG1295	ribonuclease BN
FOF52_RS18960	COG1959	2 iron, 2 sulfur cluster binding
FOF52_RS18970	COG0183	Belongs to the thiolase family
FOF52_RS18985	COG2205	protein histidine kinase activity
FOF52_RS18990	COG0745	RESPONSE REGULATOR receiver
FOF52_RS19000	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
FOF52_RS19085	COG2353	YceI-like domain
FOF52_RS19090	COG0018	arginyl-trna synthetase
FOF52_RS19100	COG0416	fatty acid biosynthetic process
FOF52_RS19105	COG1509	lysine 2,3-aminomutase activity
FOF52_RS19110	COG1940	carbohydrate kinase activity
FOF52_RS19125	COG1024	Enoyl-CoA hydratase
FOF52_RS19180	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
FOF52_RS19185	COG1012	belongs to the aldehyde dehydrogenase family
FOF52_RS19190	COG3842	ATPase activity
FOF52_RS19200	COG1176	ABC-type spermidine putrescine transport system, permease component I
FOF52_RS19205	COG1177	transmembrane transport
FOF52_RS19210	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FOF52_RS19220	COG0784	Response regulator, receiver
FOF52_RS19220	COG2205	protein histidine kinase activity
FOF52_RS19220	COG5002	protein histidine kinase activity
FOF52_RS19235	COG2197	response regulator
FOF52_RS19240	COG4585	Histidine kinase
FOF52_RS19280	COG1028	Short-chain dehydrogenase reductase Sdr
FOF52_RS19285	COG0631	protein serine/threonine phosphatase activity
FOF52_RS19290	COG2372	response to copper ion
FOF52_RS19300	COG0456	acetyltransferase
FOF52_RS19310	COG1917	Cupin 2, conserved barrel domain protein
FOF52_RS19315	COG5285	phytanoyl-CoA dioxygenase
FOF52_RS19325	COG0765	amino acid transport
FOF52_RS19330	COG0765	amino acid transport
FOF52_RS19335	COG1126	abc transporter atp-binding protein
FOF52_RS19350	COG1492	cobalamin metabolic process
FOF52_RS19360	COG1797	cobyrinic acid a,c-diamide synthase activity
FOF52_RS19415	COG1120	ATPase activity
FOF52_RS19420	COG4139	cobalamin transport
FOF52_RS19445	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
FOF52_RS19450	COG0406	alpha-ribazole phosphatase activity
FOF52_RS19450	COG0494	nUDIX hydrolase
FOF52_RS19515	COG1120	ATPase activity
FOF52_RS19520	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FOF52_RS19525	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FOF52_RS19545	COG2301	Belongs to the HpcH HpaI aldolase family
FOF52_RS19555	COG0745	RESPONSE REGULATOR receiver
FOF52_RS19565	COG2188	Transcriptional regulator
FOF52_RS19585	COG1320	monovalent cation:proton antiporter activity
FOF52_RS19590	COG2212	antiporter activity
FOF52_RS19600	COG0651	ATP synthesis coupled electron transport
FOF52_RS19605	COG1006	Multisubunit Na H antiporter MnhC subunit
FOF52_RS19610	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
FOF52_RS19610	COG2111	Na H antiporter
FOF52_RS19615	COG1846	Transcriptional regulator
FOF52_RS19625	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FOF52_RS19645	COG0589	response to stress
FOF52_RS19655	COG3384	dioxygenase
FOF52_RS19660	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
FOF52_RS19665	COG3321	synthase
FOF52_RS19665	COG0604	alcohol dehydrogenase
FOF52_RS19665	COG1028	Short-chain dehydrogenase reductase Sdr
FOF52_RS19670	COG1028	Short-chain dehydrogenase reductase Sdr
FOF52_RS19725	COG1876	peptidase activity
FOF52_RS19730	COG1970	mechanosensitive ion channel activity
FOF52_RS19755	COG1210	Utp--glucose-1-phosphate uridylyltransferase
FOF52_RS19765	COG0315	cyclic pyranopterin monophosphate synthase activity
FOF52_RS19770	COG0315	cyclic pyranopterin monophosphate synthase activity
FOF52_RS19770	COG0521	Mo-molybdopterin cofactor biosynthetic process
FOF52_RS19775	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
FOF52_RS19800	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
FOF52_RS19830	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
FOF52_RS19840	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FOF52_RS19860	COG0084	hydrolase, TatD family'
FOF52_RS19865	COG1804	L-carnitine dehydratase bile acid-inducible protein F
FOF52_RS19900	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
FOF52_RS19910	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
FOF52_RS19920	COG0488	(ABC) transporter
FOF52_RS19930	COG1846	Transcriptional regulator
FOF52_RS19950	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
FOF52_RS19955	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
FOF52_RS19960	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
FOF52_RS19965	COG0193	aminoacyl-tRNA hydrolase activity
FOF52_RS19970	COG1218	3'(2'),5'-bisphosphate nucleotidase
FOF52_RS19985	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
FOF52_RS19990	COG1959	2 iron, 2 sulfur cluster binding
FOF52_RS19995	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
FOF52_RS19995	COG1017	nitric oxide dioxygenase activity
FOF52_RS20010	COG0529	Catalyzes the synthesis of activated sulfate
FOF52_RS20025	COG0730	response to heat
FOF52_RS20030	COG0148	phosphopyruvate hydratase activity
FOF52_RS20050	COG1252	NADH dehydrogenase
FOF52_RS20060	COG1012	belongs to the aldehyde dehydrogenase family
FOF52_RS20065	COG0506	proline dehydrogenase activity
FOF52_RS20080	COG0183	Belongs to the thiolase family
FOF52_RS20085	COG2755	lipolytic protein G-D-S-L family
FOF52_RS20115	COG0110	maltose O-acetyltransferase activity
FOF52_RS20140	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
FOF52_RS20155	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
FOF52_RS20165	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
FOF52_RS20175	COG1331	Highly conserved protein containing a thioredoxin domain
FOF52_RS20185	COG2815	serine threonine protein kinase
FOF52_RS20185	COG0515	serine threonine protein kinase
FOF52_RS20195	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
FOF52_RS20200	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
FOF52_RS20210	COG0114	fumarate hydratase activity
FOF52_RS20220	COG1131	(ABC) transporter
FOF52_RS20265	COG1722	exodeoxyribonuclease VII activity
FOF52_RS20270	COG1570	exodeoxyribonuclease VII activity
FOF52_RS20285	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
FOF52_RS20295	COG1322	Protein conserved in bacteria
FOF52_RS20300	COG0012	GTP binding
FOF52_RS20400	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
FOF52_RS20410	COG1994	Peptidase M50
FOF52_RS20440	COG2171	N-acyltransferase activity
FOF52_RS20445	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
FOF52_RS20460	COG2818	Glycosylase
FOF52_RS20475	COG1024	Enoyl-CoA hydratase
FOF52_RS20485	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
FOF52_RS20490	COG1595	DNA-templated transcription, initiation
FOF52_RS20505	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FOF52_RS20525	COG0613	PHP domain protein
FOF52_RS20540	COG0513	Belongs to the DEAD box helicase family
FOF52_RS20555	COG0668	transmembrane transport
FOF52_RS20625	COG1946	Acyl-CoA thioesterase
FOF52_RS20650	COG0415	Belongs to the DNA photolyase family
FOF52_RS20670	COG0314	molybdopterin synthase activity
FOF52_RS20675	COG3480	Lon protease (S16) C-terminal proteolytic domain
FOF52_RS20685	COG1615	UPF0182 protein
FOF52_RS20720	COG0483	inositol monophosphate 1-phosphatase activity
FOF52_RS20730	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
FOF52_RS20745	COG2135	peptidase activity
FOF52_RS20750	COG2226	methyltransferase
FOF52_RS20755	COG1595	DNA-templated transcription, initiation
FOF52_RS20760	COG5662	AntiSigma factor
FOF52_RS20765	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
FOF52_RS20765	COG2199	diguanylate cyclase activity
FOF52_RS20775	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
FOF52_RS20790	COG2188	Transcriptional regulator
FOF52_RS20805	COG1597	lipid kinase activity
FOF52_RS20820	COG2172	sigma factor antagonist activity
FOF52_RS20830	COG1126	abc transporter atp-binding protein
FOF52_RS20835	COG0765	amino acid transport
FOF52_RS20840	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FOF52_RS20845	COG0281	malic enzyme
FOF52_RS20865	COG0508	dehydrogenase complex catalyzes the overall conversion of
FOF52_RS20865	COG0567	Dehydrogenase, E1 component
FOF52_RS20870	COG1028	Short-chain dehydrogenase reductase Sdr
FOF52_RS20890	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
FOF52_RS20900	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
FOF52_RS20905	COG0438	transferase activity, transferring glycosyl groups
FOF52_RS20915	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
FOF52_RS20935	COG0616	signal peptide processing
FOF52_RS20950	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
FOF52_RS20960	COG0366	Alpha amylase catalytic
FOF52_RS20965	COG0366	Alpha amylase catalytic
FOF52_RS20970	COG0058	SHG alpha-glucan phosphorylase activity
FOF52_RS20980	COG1122	ATPase activity
FOF52_RS21010	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
FOF52_RS21045	COG0482	sulfurtransferase activity
FOF52_RS21060	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
FOF52_RS21070	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
FOF52_RS21075	COG0154	amidase activity
FOF52_RS21090	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
FOF52_RS21095	COG5001	Diguanylate cyclase
FOF52_RS21095	COG3300	MHYT domain
FOF52_RS21110	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
FOF52_RS21115	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
FOF52_RS21120	COG0473	3-isopropylmalate dehydrogenase activity
FOF52_RS21125	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
FOF52_RS21130	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
FOF52_RS21145	COG5297	Belongs to the glycosyl hydrolase family 6
FOF52_RS21150	COG0179	Fumarylacetoacetate (FAA) hydrolase
FOF52_RS21160	COG2311	Membrane
FOF52_RS21170	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
FOF52_RS21190	COG2133	pyrroloquinoline quinone binding
FOF52_RS21200	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
FOF52_RS21205	COG0066	3-isopropylmalate dehydratase activity
FOF52_RS21220	COG1920	GTP binding
FOF52_RS21230	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
FOF52_RS21240	COG0626	cystathionine gamma-synthase activity
FOF52_RS21245	COG1181	Belongs to the D-alanine--D-alanine ligase family
FOF52_RS21260	COG4988	ABC transporter
FOF52_RS21265	COG1294	oxidase, subunit
FOF52_RS21270	COG1271	oxidase subunit
FOF52_RS21305	COG0227	Belongs to the bacterial ribosomal protein bL28 family
FOF52_RS21310	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
FOF52_RS21315	COG0742	ribosomal rna small subunit methyltransferase
FOF52_RS21320	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
FOF52_RS21325	COG1399	metal-binding, possibly nucleic acid-binding protein
FOF52_RS21330	COG0333	Belongs to the bacterial ribosomal protein bL32 family
FOF52_RS21335	COG0571	ribonuclease III activity
FOF52_RS21340	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
FOF52_RS21345	COG1254	Belongs to the acylphosphatase family
FOF52_RS21360	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
FOF52_RS21365	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FOF52_RS21370	COG0552	protein localization to endoplasmic reticulum
FOF52_RS21380	COG1131	(ABC) transporter
FOF52_RS21385	COG1510	regulation of RNA biosynthetic process
FOF52_RS21405	COG0228	four-way junction DNA binding
FOF52_RS21410	COG1837	Belongs to the UPF0109 family
FOF52_RS21415	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
FOF52_RS21420	COG0336	Belongs to the RNA methyltransferase TrmD family
FOF52_RS21425	COG0335	large ribosomal subunit rRNA binding
FOF52_RS21445	COG0792	nuclease activity
FOF52_RS21470	COG4974	Belongs to the 'phage' integrase family
FOF52_RS21480	COG0052	Belongs to the universal ribosomal protein uS2 family
FOF52_RS21485	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
FOF52_RS21490	COG0528	UMP kinase activity
FOF52_RS21495	COG0233	cytoplasmic translational termination
FOF52_RS21500	COG0575	Belongs to the CDS family
FOF52_RS21515	COG0820	rRNA (adenine-C2-)-methyltransferase activity
FOF52_RS21525	COG1522	sequence-specific DNA binding
FOF52_RS21535	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
FOF52_RS21595	COG1105	Belongs to the carbohydrate kinase PfkB family
FOF52_RS21605	COG1028	Short-chain dehydrogenase reductase Sdr
FOF52_RS21635	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FOF52_RS21665	COG1401	restriction endodeoxyribonuclease activity
FOF52_RS21695	COG1201	RNA secondary structure unwinding
FOF52_RS21705	COG2409	Drug exporters of the RND superfamily
FOF52_RS21715	COG0456	acetyltransferase
FOF52_RS21755	COG0318	PFAM AMP-dependent synthetase and ligase
FOF52_RS21760	COG3619	membrane
FOF52_RS21770	COG1401	restriction endodeoxyribonuclease activity
FOF52_RS21830	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair