locus-tag	class	description
IM867_RS00025	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
IM867_RS00035	COG1335	isochorismatase
IM867_RS00085	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
IM867_RS00090	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IM867_RS00110	COG1678	Uncharacterized ACR, COG1678
IM867_RS00135	COG0183	Belongs to the thiolase family
IM867_RS00140	COG0346	lactoylglutathione lyase activity
IM867_RS00170	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
IM867_RS00195	COG0355	proton-transporting ATP synthase activity, rotational mechanism
IM867_RS00200	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
IM867_RS00205	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
IM867_RS00210	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
IM867_RS00215	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
IM867_RS00220	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
IM867_RS00225	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
IM867_RS00245	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
IM867_RS00255	COG2890	protein-(glutamine-N5) methyltransferase activity
IM867_RS00260	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
IM867_RS00265	COG0254	rRNA binding
IM867_RS00275	COG0083	homoserine kinase activity
IM867_RS00280	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
IM867_RS00285	COG0460	homoserine dehydrogenase
IM867_RS00290	COG0019	diaminopimelate decarboxylase activity
IM867_RS00295	COG0018	arginyl-trna synthetase
IM867_RS00305	COG2272	Belongs to the type-B carboxylesterase lipase family
IM867_RS00335	COG0242	peptide deformylase activity
IM867_RS00425	COG1061	Type III restriction enzyme res subunit
IM867_RS00430	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
IM867_RS00435	COG1053	succinate dehydrogenase
IM867_RS00455	COG1217	gtp-binding protein TYPA
IM867_RS00465	COG0494	nUDIX hydrolase
IM867_RS00485	COG0277	FAD linked oxidase domain protein
IM867_RS00490	COG1028	Short-chain dehydrogenase reductase Sdr
IM867_RS00500	COG2226	methyltransferase
IM867_RS00505	COG0500	methyltransferase
IM867_RS00515	COG4981	capsule polysaccharide biosynthetic process
IM867_RS00570	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
IM867_RS00575	COG2177	Part of the ABC transporter FtsEX involved in
IM867_RS00580	COG2884	Cell division ATP-binding protein ftsE
IM867_RS00585	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
IM867_RS00595	COG2902	Dehydrogenase
IM867_RS00610	COG1011	Hydrolase
IM867_RS00615	COG1960	acyl-CoA dehydrogenase activity
IM867_RS00620	COG1472	Belongs to the glycosyl hydrolase 3 family
IM867_RS00625	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
IM867_RS00640	COG0653	protein targeting
IM867_RS00645	COG2197	response regulator
IM867_RS00650	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
IM867_RS00655	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
IM867_RS00660	COG5401	PFAM Sporulation and spore germination
IM867_RS00665	COG5002	protein histidine kinase activity
IM867_RS00665	COG5000	phosphorelay sensor kinase activity
IM867_RS00670	COG0745	RESPONSE REGULATOR receiver
IM867_RS00690	COG0714	Associated with various cellular activities
IM867_RS00715	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
IM867_RS00735	COG2835	tetraacyldisaccharide 4'-kinase activity
IM867_RS00775	COG0391	Required for morphogenesis under gluconeogenic growth conditions
IM867_RS00780	COG0778	Nitroreductase
IM867_RS00780	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
IM867_RS00785	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
IM867_RS00790	COG2226	methyltransferase
IM867_RS00800	COG0438	transferase activity, transferring glycosyl groups
IM867_RS00820	COG1316	TRANSCRIPTIONal
IM867_RS00840	COG0778	Nitroreductase
IM867_RS00855	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
IM867_RS00885	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
IM867_RS00900	COG1316	TRANSCRIPTIONal
IM867_RS00910	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
IM867_RS00915	COG1832	CoA-binding protein
IM867_RS00920	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
IM867_RS00935	COG0745	RESPONSE REGULATOR receiver
IM867_RS00940	COG2205	protein histidine kinase activity
IM867_RS00950	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
IM867_RS00955	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
IM867_RS00955	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
IM867_RS00960	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
IM867_RS00965	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
IM867_RS00975	COG4770	biotin carboxylase activity
IM867_RS01000	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
IM867_RS01005	COG1473	amidohydrolase
IM867_RS01005	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
IM867_RS01010	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
IM867_RS01020	COG1316	TRANSCRIPTIONal
IM867_RS01040	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
IM867_RS01045	COG0138	bifunctional purine biosynthesis protein purh
IM867_RS01070	COG0045	succinate-CoA ligase (ADP-forming) activity
IM867_RS01110	COG2197	response regulator
IM867_RS01115	COG4585	Histidine kinase
IM867_RS01145	COG0518	GMP synthase (glutamine-hydrolyzing) activity
IM867_RS01145	COG0519	Catalyzes the synthesis of GMP from XMP
IM867_RS01150	COG1012	belongs to the aldehyde dehydrogenase family
IM867_RS01155	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
IM867_RS01160	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
IM867_RS01165	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
IM867_RS01175	COG0516	GMP reductase activity
IM867_RS01185	COG1595	DNA-templated transcription, initiation
IM867_RS01190	COG0459	protein refolding
IM867_RS01195	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
IM867_RS01210	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
IM867_RS01215	COG1247	-acetyltransferase
IM867_RS01220	COG1214	PFAM Peptidase M22, glycoprotease
IM867_RS01220	COG0456	acetyltransferase
IM867_RS01225	COG0802	atpase or kinase
IM867_RS01230	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
IM867_RS01250	COG1072	(Pantothenic acid kinase))
IM867_RS01255	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
IM867_RS01260	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
IM867_RS01265	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
IM867_RS01270	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
IM867_RS01280	COG0101	tRNA pseudouridine synthase activity
IM867_RS01285	COG0203	ribosomal protein L17
IM867_RS01290	COG0202	RNA polymerase activity
IM867_RS01295	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
IM867_RS01300	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
IM867_RS01305	COG0257	Belongs to the bacterial ribosomal protein bL36 family
IM867_RS01310	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
IM867_RS01320	COG0024	Methionine aminopeptidase
IM867_RS01325	COG0563	adenylate kinase activity
IM867_RS01335	COG0200	Binds to the 23S rRNA
IM867_RS01340	COG1841	ribosomal large subunit assembly
IM867_RS01345	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
IM867_RS01350	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
IM867_RS01355	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
IM867_RS01360	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
IM867_RS01365	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
IM867_RS01370	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
IM867_RS01375	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
IM867_RS01380	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
IM867_RS01385	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
IM867_RS01390	COG0255	Belongs to the universal ribosomal protein uL29 family
IM867_RS01395	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
IM867_RS01400	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
IM867_RS01405	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
IM867_RS01410	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
IM867_RS01415	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
IM867_RS01420	COG0089	rRNA binding
IM867_RS01425	COG0088	Forms part of the polypeptide exit tunnel
IM867_RS01430	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
IM867_RS01435	COG0051	transcription antitermination factor activity, RNA binding
IM867_RS01440	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
IM867_RS01445	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
IM867_RS01450	COG0049	tRNA binding
IM867_RS01455	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
IM867_RS01465	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
IM867_RS01470	COG0085	RNA polymerase activity
IM867_RS01475	COG0222	ribosome binding
IM867_RS01480	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
IM867_RS01485	COG0081	regulation of translation
IM867_RS01490	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
IM867_RS01500	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
IM867_RS01510	COG0436	Aminotransferase
IM867_RS01515	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
IM867_RS01520	COG2119	membrane
IM867_RS01525	COG0812	UDP-N-acetylmuramate dehydrogenase activity
IM867_RS01535	COG2030	dehydratase
IM867_RS01540	COG0267	Belongs to the bacterial ribosomal protein bL33 family
IM867_RS01555	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
IM867_RS01580	COG1666	GTP binding
IM867_RS01585	COG0501	Belongs to the peptidase M48B family
IM867_RS01590	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
IM867_RS01590	COG0674	pyruvate-flavodoxin oxidoreductase activity
IM867_RS01595	COG1013	pyruvate-flavodoxin oxidoreductase activity
IM867_RS01600	COG0702	epimerase
IM867_RS01610	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
IM867_RS01625	COG0142	geranyltranstransferase activity
IM867_RS01630	COG1007	ATP synthesis coupled electron transport
IM867_RS01645	COG0713	ATP synthesis coupled electron transport
IM867_RS01655	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IM867_RS01660	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
IM867_RS01665	COG1034	ATP synthesis coupled electron transport
IM867_RS01670	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
IM867_RS01680	COG0649	NAD binding
IM867_RS01685	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IM867_RS01690	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IM867_RS01705	COG2226	methyltransferase
IM867_RS01725	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
IM867_RS01730	COG1333	cytochrome c biogenesis protein
IM867_RS01735	COG0785	Cytochrome C biogenesis protein
IM867_RS01740	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IM867_RS01755	COG0123	including yeast histone deacetylase and acetoin utilization protein
IM867_RS01765	COG1082	Xylose isomerase domain protein TIM barrel
IM867_RS01770	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
IM867_RS01785	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
IM867_RS01805	COG2897	thiosulfate sulfurtransferase activity
IM867_RS01835	COG0406	alpha-ribazole phosphatase activity
IM867_RS01840	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
IM867_RS01845	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
IM867_RS01860	COG0113	porphobilinogen synthase activity
IM867_RS01870	COG0181	hydroxymethylbilane synthase activity
IM867_RS01875	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
IM867_RS01880	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
IM867_RS01895	COG0745	RESPONSE REGULATOR receiver
IM867_RS01905	COG0456	acetyltransferase
IM867_RS01925	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
IM867_RS01930	COG0306	phosphate transporter
IM867_RS01950	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
IM867_RS01970	COG3339	Conserved Protein
IM867_RS01975	COG0860	N-Acetylmuramoyl-L-alanine amidase
IM867_RS02000	COG1739	Uncharacterized protein family UPF0029
IM867_RS02010	COG0386	Belongs to the glutathione peroxidase family
IM867_RS02040	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
IM867_RS02055	COG1486	melibiose metabolic process
IM867_RS02065	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IM867_RS02140	COG0494	nUDIX hydrolase
IM867_RS02175	COG0582	viral genome integration into host DNA
IM867_RS02215	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
IM867_RS02220	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
IM867_RS02220	COG1754	DNA topoisomerase type I activity
IM867_RS02230	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IM867_RS02245	COG0675	Transposase, IS605 OrfB family
IM867_RS02260	COG1609	Transcriptional regulator
IM867_RS02295	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IM867_RS02300	COG2508	Transcriptional regulator
IM867_RS02300	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
IM867_RS02345	COG2205	protein histidine kinase activity
IM867_RS02350	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
IM867_RS02355	COG2197	response regulator
IM867_RS02365	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
IM867_RS02365	COG1703	isobutyryl-CoA mutase activity
IM867_RS02365	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
IM867_RS02380	COG1063	alcohol dehydrogenase
IM867_RS02385	COG2267	carboxylic ester hydrolase activity
IM867_RS02395	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IM867_RS02400	COG4260	virion core protein, lumpy skin disease virus
IM867_RS02415	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
IM867_RS02420	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
IM867_RS02450	COG0693	protein deglycase activity
IM867_RS02460	COG1309	transcriptional regulator
IM867_RS02465	COG2814	Major facilitator Superfamily
IM867_RS02480	COG2255	four-way junction helicase activity
IM867_RS02515	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IM867_RS02525	COG3629	intracellular signal transduction
IM867_RS02525	COG3903	Transcriptional regulator
IM867_RS02535	COG0515	serine threonine protein kinase
IM867_RS02545	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
IM867_RS02605	COG1983	PspC domain protein
IM867_RS02610	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
IM867_RS02615	COG3275	phosphorelay sensor kinase activity
IM867_RS02620	COG3279	Response regulator of the LytR AlgR family
IM867_RS02640	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
IM867_RS02695	COG3485	protocatechuate 3,4-dioxygenase
IM867_RS02700	COG0354	folic acid binding
IM867_RS02735	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
IM867_RS02745	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
IM867_RS02750	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
IM867_RS02755	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
IM867_RS02760	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
IM867_RS02795	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
IM867_RS02805	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
IM867_RS02810	COG0302	gtp cyclohydrolase
IM867_RS02825	COG0037	tRNA processing
IM867_RS02850	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
IM867_RS02855	COG2027	D-alanyl-D-alanine carboxypeptidase
IM867_RS02870	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
IM867_RS02875	COG1329	Transcriptional regulator
IM867_RS02885	COG5002	protein histidine kinase activity
IM867_RS02895	COG0588	phosphoglycerate mutase activity
IM867_RS02905	COG0438	transferase activity, transferring glycosyl groups
IM867_RS02950	COG1490	D-aminoacyl-tRNA deacylase activity
IM867_RS02980	COG2113	Glycine betaine
IM867_RS02990	COG4175	Glycine betaine
IM867_RS02990	COG0517	IMP dehydrogenase activity
IM867_RS03000	COG0717	Belongs to the dCTP deaminase family
IM867_RS03020	COG2188	Transcriptional regulator
IM867_RS03030	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IM867_RS03055	COG0582	viral genome integration into host DNA
IM867_RS03090	COG0352	thiamine-phosphate diphosphorylase activity
IM867_RS03090	COG0351	phosphomethylpyrimidine kinase
IM867_RS03090	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
IM867_RS03105	COG1316	TRANSCRIPTIONal
IM867_RS03125	COG2205	protein histidine kinase activity
IM867_RS03175	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
IM867_RS03180	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
IM867_RS03200	COG2124	cytochrome p450
IM867_RS03205	COG2124	cytochrome p450
IM867_RS03305	COG0435	Glutathione S-transferase
IM867_RS03315	COG2409	Drug exporters of the RND superfamily
IM867_RS03335	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
IM867_RS03335	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
IM867_RS03340	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
IM867_RS03345	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
IM867_RS03365	COG1324	tolerance protein
IM867_RS03370	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
IM867_RS03390	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
IM867_RS03395	COG0151	Belongs to the GarS family
IM867_RS03400	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
IM867_RS03405	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
IM867_RS03410	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
IM867_RS03420	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
IM867_RS03440	COG1595	DNA-templated transcription, initiation
IM867_RS03480	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
IM867_RS03485	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
IM867_RS03495	COG0589	response to stress
IM867_RS03540	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IM867_RS03570	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
IM867_RS03575	COG0022	dehydrogenase e1 component
IM867_RS03575	COG0508	dehydrogenase complex catalyzes the overall conversion of
IM867_RS03580	COG0508	dehydrogenase complex catalyzes the overall conversion of
IM867_RS03590	COG0077	Prephenate dehydratase
IM867_RS03595	COG0463	Glycosyl transferase, family 2
IM867_RS03610	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
IM867_RS03630	COG1716	ATPase activity
IM867_RS03635	COG0631	protein serine/threonine phosphatase activity
IM867_RS03635	COG3266	domain, Protein
IM867_RS03645	COG0768	penicillin binding
IM867_RS03650	COG0515	serine threonine protein kinase
IM867_RS03655	COG0515	serine threonine protein kinase
IM867_RS03665	COG0705	Rhomboid family
IM867_RS03720	COG3621	Patatin-like phospholipase
IM867_RS03750	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
IM867_RS03755	COG1309	transcriptional regulator
IM867_RS03770	COG0702	epimerase
IM867_RS03785	COG0456	acetyltransferase
IM867_RS03815	COG0739	heme binding
IM867_RS03815	COG0741	lytic transglycosylase activity
IM867_RS03815	COG1196	nuclear chromosome segregation
IM867_RS03920	COG2837	iron assimilation
IM867_RS03945	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
IM867_RS03955	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IM867_RS03980	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
IM867_RS03990	COG0359	binds to the 23S rRNA
IM867_RS03995	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
IM867_RS04000	COG0629	single-stranded DNA binding
IM867_RS04005	COG0360	Binds together with S18 to 16S ribosomal RNA
IM867_RS04015	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
IM867_RS04015	COG4499	WXG100 protein secretion system (Wss), protein YukC
IM867_RS04055	COG2815	serine threonine protein kinase
IM867_RS04055	COG0515	serine threonine protein kinase
IM867_RS04060	COG1595	DNA-templated transcription, initiation
IM867_RS04070	COG0492	ferredoxin-NADP+ reductase activity
IM867_RS04075	COG3118	belongs to the thioredoxin family
IM867_RS04085	COG1192	Involved in chromosome partitioning
IM867_RS04090	COG0357	Ribosomal RNA small subunit methyltransferase G
IM867_RS04100	COG0706	membrane insertase activity
IM867_RS04105	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
IM867_RS04110	COG0594	ribonuclease P activity
IM867_RS04115	COG0230	Belongs to the bacterial ribosomal protein bL34 family
IM867_RS04120	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
IM867_RS04125	COG0592	DNA-directed DNA polymerase activity
IM867_RS04130	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
IM867_RS04135	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
IM867_RS04140	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
IM867_RS04145	COG0187	DNA topoisomerase II activity
IM867_RS04150	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
IM867_RS04170	COG2089	acid synthase
IM867_RS04175	COG1216	Glycosyl transferase, family 2
IM867_RS04200	COG1482	cell wall glycoprotein biosynthetic process
IM867_RS04205	COG1316	TRANSCRIPTIONal
IM867_RS04210	COG0305	Participates in initiation and elongation during chromosome replication
IM867_RS04230	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
IM867_RS04260	COG0583	DNA-binding transcription factor activity
IM867_RS04270	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
IM867_RS04335	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
IM867_RS04340	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
IM867_RS04345	COG0587	DNA-directed DNA polymerase activity
IM867_RS04410	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
IM867_RS04415	COG1518	maintenance of DNA repeat elements
IM867_RS04475	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
IM867_RS04555	COG0515	serine threonine protein kinase
IM867_RS04555	COG2815	serine threonine protein kinase
IM867_RS04560	COG0210	DNA helicase
IM867_RS04580	COG1960	acyl-CoA dehydrogenase activity
IM867_RS04600	COG3321	synthase
IM867_RS04600	COG1028	Short-chain dehydrogenase reductase Sdr
IM867_RS04600	COG0604	alcohol dehydrogenase
IM867_RS04635	COG2267	carboxylic ester hydrolase activity
IM867_RS04645	COG1028	Short-chain dehydrogenase reductase Sdr
IM867_RS04655	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
IM867_RS04675	COG0592	DNA-directed DNA polymerase activity
IM867_RS04710	COG0039	L-malate dehydrogenase activity
IM867_RS04730	COG0384	phenazine biosynthesis protein PhzF
IM867_RS04750	COG2183	response to ionizing radiation
IM867_RS04775	COG0488	(ABC) transporter
IM867_RS04795	COG1408	metallophosphoesterase
IM867_RS04805	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
IM867_RS04840	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IM867_RS04870	COG1366	Belongs to the anti-sigma-factor antagonist family
IM867_RS04875	COG1111	helicase
IM867_RS04875	COG1205	dead DEAH box helicase
IM867_RS04925	COG0596	Alpha beta hydrolase
IM867_RS04935	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
IM867_RS04940	COG0406	alpha-ribazole phosphatase activity
IM867_RS04945	COG3830	Belongs to the UPF0237 family
IM867_RS04945	COG0560	Phosphoserine phosphatase
IM867_RS04960	COG1119	ATPase activity
IM867_RS04985	COG1309	transcriptional regulator
IM867_RS04990	COG2843	Capsule synthesis protein
IM867_RS05035	COG3866	Pectate lyase
IM867_RS05045	COG0657	acetylesterase activity
IM867_RS05050	COG0047	phosphoribosylformylglycinamidine synthase activity
IM867_RS05060	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
IM867_RS05080	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
IM867_RS05110	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
IM867_RS05115	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IM867_RS05130	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IM867_RS05140	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
IM867_RS05145	COG0140	phosphoribosyl-ATP diphosphatase activity
IM867_RS05160	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
IM867_RS05165	COG1595	DNA-templated transcription, initiation
IM867_RS05175	COG0022	dehydrogenase e1 component
IM867_RS05180	COG0508	dehydrogenase complex catalyzes the overall conversion of
IM867_RS05195	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
IM867_RS05200	COG0706	membrane insertase activity
IM867_RS05215	COG0800	Aldolase
IM867_RS05250	COG2181	nitrate reductase activity
IM867_RS05250	COG0247	lactate metabolic process
IM867_RS05255	COG0443	Heat shock 70 kDa protein
IM867_RS05260	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
IM867_RS05265	COG0484	heat shock protein binding
IM867_RS05270	COG0789	Transcriptional regulator
IM867_RS05275	COG0542	response to heat
IM867_RS05300	COG2226	methyltransferase
IM867_RS05305	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
IM867_RS05310	COG3629	intracellular signal transduction
IM867_RS05310	COG3903	Transcriptional regulator
IM867_RS05325	COG1960	acyl-CoA dehydrogenase activity
IM867_RS05335	COG0215	cysteine-tRNA ligase activity
IM867_RS05340	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IM867_RS05425	COG0459	protein refolding
IM867_RS05450	COG1278	Cold shock
IM867_RS05480	COG2252	PERMEase
IM867_RS05485	COG1846	Transcriptional regulator
IM867_RS05495	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
IM867_RS05505	COG0584	glycerophosphoryl diester phosphodiesterase
IM867_RS05520	COG0259	pyridoxamine-phosphate oxidase activity
IM867_RS05535	COG1295	ribonuclease BN
IM867_RS05535	COG1959	2 iron, 2 sulfur cluster binding
IM867_RS05545	COG0183	Belongs to the thiolase family
IM867_RS05560	COG2205	protein histidine kinase activity
IM867_RS05565	COG0745	RESPONSE REGULATOR receiver
IM867_RS05575	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IM867_RS05620	COG2353	YceI-like domain
IM867_RS05625	COG0018	arginyl-trna synthetase
IM867_RS05635	COG0416	fatty acid biosynthetic process
IM867_RS05640	COG1509	lysine 2,3-aminomutase activity
IM867_RS05645	COG1940	carbohydrate kinase activity
IM867_RS05660	COG1024	Enoyl-CoA hydratase
IM867_RS05670	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
IM867_RS05675	COG1012	belongs to the aldehyde dehydrogenase family
IM867_RS05680	COG3842	ATPase activity
IM867_RS05690	COG1176	ABC-type spermidine putrescine transport system, permease component I
IM867_RS05695	COG1177	transmembrane transport
IM867_RS05700	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IM867_RS05710	COG2205	protein histidine kinase activity
IM867_RS05710	COG3850	Histidine kinase
IM867_RS05710	COG4999	Histidine kinase
IM867_RS05710	COG3437	response regulator, receiver
IM867_RS05715	COG2770	Histidine kinase
IM867_RS05715	COG2208	phosphoserine phosphatase activity
IM867_RS05720	COG2197	response regulator
IM867_RS05725	COG4585	Histidine kinase
IM867_RS05755	COG0438	transferase activity, transferring glycosyl groups
IM867_RS05760	COG0631	protein serine/threonine phosphatase activity
IM867_RS05765	COG2372	response to copper ion
IM867_RS05775	COG0456	acetyltransferase
IM867_RS05785	COG1917	Cupin 2, conserved barrel domain protein
IM867_RS05795	COG0765	amino acid transport
IM867_RS05800	COG0765	amino acid transport
IM867_RS05805	COG1126	abc transporter atp-binding protein
IM867_RS05830	COG1797	cobyrinic acid a,c-diamide synthase activity
IM867_RS05890	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
IM867_RS05915	COG0725	ABC transporter, periplasmic molybdate-binding protein
IM867_RS05965	COG1120	ATPase activity
IM867_RS05970	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IM867_RS05975	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IM867_RS05990	COG2301	Belongs to the HpcH HpaI aldolase family
IM867_RS06000	COG0745	RESPONSE REGULATOR receiver
IM867_RS06010	COG1320	monovalent cation:proton antiporter activity
IM867_RS06015	COG2212	antiporter activity
IM867_RS06025	COG0651	ATP synthesis coupled electron transport
IM867_RS06030	COG1006	Multisubunit Na H antiporter MnhC subunit
IM867_RS06035	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
IM867_RS06035	COG2111	Na H antiporter
IM867_RS06040	COG1846	Transcriptional regulator
IM867_RS06050	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IM867_RS06070	COG0589	response to stress
IM867_RS06075	COG3384	dioxygenase
IM867_RS06080	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
IM867_RS06090	COG1028	Short-chain dehydrogenase reductase Sdr
IM867_RS06130	COG1876	peptidase activity
IM867_RS06150	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
IM867_RS06155	COG1210	Utp--glucose-1-phosphate uridylyltransferase
IM867_RS06165	COG0315	cyclic pyranopterin monophosphate synthase activity
IM867_RS06170	COG0315	cyclic pyranopterin monophosphate synthase activity
IM867_RS06170	COG0521	Mo-molybdopterin cofactor biosynthetic process
IM867_RS06175	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
IM867_RS06200	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
IM867_RS06230	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
IM867_RS06240	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IM867_RS06285	COG0084	hydrolase, TatD family'
IM867_RS06290	COG1804	L-carnitine dehydratase bile acid-inducible protein F
IM867_RS06305	COG2255	four-way junction helicase activity
IM867_RS06325	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
IM867_RS06335	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
IM867_RS06345	COG0488	(ABC) transporter
IM867_RS06375	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
IM867_RS06380	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
IM867_RS06385	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
IM867_RS06390	COG0193	aminoacyl-tRNA hydrolase activity
IM867_RS06395	COG1218	3'(2'),5'-bisphosphate nucleotidase
IM867_RS06415	COG1959	2 iron, 2 sulfur cluster binding
IM867_RS06430	COG0529	Catalyzes the synthesis of activated sulfate
IM867_RS06445	COG0148	phosphopyruvate hydratase activity
IM867_RS06465	COG1252	NADH dehydrogenase
IM867_RS06475	COG1012	belongs to the aldehyde dehydrogenase family
IM867_RS06480	COG0506	proline dehydrogenase activity
IM867_RS06490	COG0183	Belongs to the thiolase family
IM867_RS06495	COG2755	lipolytic protein G-D-S-L family
IM867_RS06505	COG0110	maltose O-acetyltransferase activity
IM867_RS06530	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
IM867_RS06545	COG1714	RDD family
IM867_RS06550	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
IM867_RS06560	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
IM867_RS06570	COG1331	Highly conserved protein containing a thioredoxin domain
IM867_RS06585	COG2815	serine threonine protein kinase
IM867_RS06585	COG0515	serine threonine protein kinase
IM867_RS06590	COG1595	DNA-templated transcription, initiation
IM867_RS06595	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
IM867_RS06600	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
IM867_RS06610	COG0114	fumarate hydratase activity
IM867_RS06650	COG1722	exodeoxyribonuclease VII activity
IM867_RS06655	COG1570	exodeoxyribonuclease VII activity
IM867_RS06670	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
IM867_RS06680	COG0012	GTP binding
IM867_RS06700	COG2255	four-way junction helicase activity
IM867_RS06755	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
IM867_RS06765	COG1994	Peptidase M50
IM867_RS06795	COG2171	N-acyltransferase activity
IM867_RS06800	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IM867_RS06805	COG1611	Belongs to the LOG family
IM867_RS06815	COG2818	Glycosylase
IM867_RS06840	COG0675	Transposase, IS605 OrfB family
IM867_RS06855	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
IM867_RS06860	COG1595	DNA-templated transcription, initiation
IM867_RS06875	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IM867_RS06895	COG0613	PHP domain protein
IM867_RS06910	COG0513	Belongs to the DEAD box helicase family
IM867_RS06955	COG0210	DNA helicase
IM867_RS06975	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IM867_RS07000	COG1946	Acyl-CoA thioesterase
IM867_RS07015	COG0415	Belongs to the DNA photolyase family
IM867_RS07040	COG3480	Lon protease (S16) C-terminal proteolytic domain
IM867_RS07050	COG1615	UPF0182 protein
IM867_RS07065	COG0483	inositol monophosphate 1-phosphatase activity
IM867_RS07070	COG1162	GTPase activity
IM867_RS07075	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
IM867_RS07085	COG2135	peptidase activity
IM867_RS07090	COG2226	methyltransferase
IM867_RS07095	COG1595	DNA-templated transcription, initiation
IM867_RS07100	COG5662	AntiSigma factor
IM867_RS07105	COG2199	diguanylate cyclase activity
IM867_RS07105	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
IM867_RS07125	COG2188	Transcriptional regulator
IM867_RS07140	COG1597	lipid kinase activity
IM867_RS07155	COG2172	sigma factor antagonist activity
IM867_RS07165	COG0281	malic enzyme
IM867_RS07185	COG0508	dehydrogenase complex catalyzes the overall conversion of
IM867_RS07185	COG0567	Dehydrogenase, E1 component
IM867_RS07205	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
IM867_RS07215	COG0500	methyltransferase
IM867_RS07230	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
IM867_RS07240	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
IM867_RS07245	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
IM867_RS07250	COG0616	signal peptide processing
IM867_RS07265	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
IM867_RS07275	COG0366	Alpha amylase catalytic
IM867_RS07280	COG0366	Alpha amylase catalytic
IM867_RS07285	COG0058	SHG alpha-glucan phosphorylase activity
IM867_RS07295	COG1122	ATPase activity
IM867_RS07300	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
IM867_RS07315	COG0515	serine threonine protein kinase
IM867_RS07315	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IM867_RS07325	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
IM867_RS07340	COG0482	sulfurtransferase activity
IM867_RS07355	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
IM867_RS07365	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
IM867_RS07370	COG0154	amidase activity
IM867_RS07385	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
IM867_RS07390	COG3300	MHYT domain
IM867_RS07390	COG5001	Diguanylate cyclase
IM867_RS07405	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
IM867_RS07410	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
IM867_RS07415	COG0473	3-isopropylmalate dehydrogenase activity
IM867_RS07420	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
IM867_RS07425	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
IM867_RS07440	COG5297	Belongs to the glycosyl hydrolase family 6
IM867_RS07445	COG0179	Fumarylacetoacetate (FAA) hydrolase
IM867_RS07455	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
IM867_RS07480	COG1414	Transcriptional regulator
IM867_RS07485	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
IM867_RS07490	COG0066	3-isopropylmalate dehydratase activity
IM867_RS07505	COG1920	GTP binding
IM867_RS07515	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
IM867_RS07525	COG1181	Belongs to the D-alanine--D-alanine ligase family
IM867_RS07535	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
IM867_RS07540	COG4988	ABC transporter
IM867_RS07545	COG1294	oxidase, subunit
IM867_RS07550	COG1271	oxidase subunit
IM867_RS07585	COG0227	Belongs to the bacterial ribosomal protein bL28 family
IM867_RS07590	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
IM867_RS07595	COG0742	ribosomal rna small subunit methyltransferase
IM867_RS07600	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
IM867_RS07610	COG0333	Belongs to the bacterial ribosomal protein bL32 family
IM867_RS07615	COG0571	ribonuclease III activity
IM867_RS07620	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
IM867_RS07625	COG1254	Belongs to the acylphosphatase family
IM867_RS07640	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
IM867_RS07645	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IM867_RS07650	COG0552	protein localization to endoplasmic reticulum
IM867_RS07670	COG0228	four-way junction DNA binding
IM867_RS07675	COG1837	Belongs to the UPF0109 family
IM867_RS07680	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
IM867_RS07685	COG0336	Belongs to the RNA methyltransferase TrmD family
IM867_RS07690	COG0335	large ribosomal subunit rRNA binding
IM867_RS07705	COG0792	nuclease activity
IM867_RS07730	COG4974	Belongs to the 'phage' integrase family
IM867_RS07740	COG0052	Belongs to the universal ribosomal protein uS2 family
IM867_RS07745	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
IM867_RS07750	COG0528	UMP kinase activity
IM867_RS07755	COG0233	cytoplasmic translational termination
IM867_RS07775	COG0820	rRNA (adenine-C2-)-methyltransferase activity
IM867_RS07780	COG1522	sequence-specific DNA binding
IM867_RS07790	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
IM867_RS07840	COG1105	Belongs to the carbohydrate kinase PfkB family
IM867_RS07910	COG1201	RNA secondary structure unwinding
IM867_RS07925	COG0758	DNA mediated transformation
IM867_RS07925	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
IM867_RS07965	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
IM867_RS07970	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
IM867_RS08015	COG2226	methyltransferase
IM867_RS08035	COG0635	Involved in the biosynthesis of porphyrin-containing compound
IM867_RS08050	COG2885	chlorophyll binding
IM867_RS08060	COG1012	belongs to the aldehyde dehydrogenase family
IM867_RS08080	COG0750	zinc metalloprotease
IM867_RS08085	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
IM867_RS08095	COG0456	acetyltransferase
IM867_RS08095	COG0454	-acetyltransferase
IM867_RS08105	COG1653	transport
IM867_RS08135	COG0124	histidyl-tRNA synthetase
IM867_RS08145	COG0653	protein targeting
IM867_RS08165	COG1294	oxidase, subunit
IM867_RS08170	COG1271	oxidase subunit
IM867_RS08175	COG2197	response regulator
IM867_RS08180	COG4585	Histidine kinase
IM867_RS08185	COG0697	spore germination
IM867_RS08200	COG0442	prolyl-tRNA aminoacylation
IM867_RS08215	COG0779	Required for maturation of 30S ribosomal subunits
IM867_RS08230	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
IM867_RS08240	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
IM867_RS08245	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
IM867_RS08255	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
IM867_RS08260	COG1185	polyribonucleotide nucleotidyltransferase activity
IM867_RS08265	COG0612	Peptidase, M16
IM867_RS08270	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
IM867_RS08275	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
IM867_RS08290	COG1950	PFAM Membrane protein of
IM867_RS08295	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IM867_RS08300	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
IM867_RS08305	COG1674	ftsk spoiiie
IM867_RS08315	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
IM867_RS08325	COG1546	Belongs to the CinA family
IM867_RS08325	COG1058	Belongs to the CinA family
IM867_RS08330	COG1396	sequence-specific DNA binding
IM867_RS08355	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
IM867_RS08355	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
IM867_RS08355	COG1372	Participates in initiation and elongation during chromosome replication
IM867_RS08355	COG1372	Participates in initiation and elongation during chromosome replication
IM867_RS08360	COG2137	regulation of response to DNA damage stimulus
IM867_RS08365	COG1418	mRNA catabolic process
IM867_RS08365	COG1566	PFAM secretion protein HlyD family protein
IM867_RS08375	COG0765	amino acid transport
IM867_RS08380	COG0765	amino acid transport
IM867_RS08385	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IM867_RS08390	COG1126	abc transporter atp-binding protein
IM867_RS08395	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
IM867_RS08415	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
IM867_RS08420	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
IM867_RS08435	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
IM867_RS08440	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
IM867_RS08445	COG1228	amidohydrolase
IM867_RS08465	COG2333	competence protein COMEC
IM867_RS08465	COG0658	competence protein
IM867_RS08475	COG0268	Binds directly to 16S ribosomal RNA
IM867_RS08485	COG0481	GTPase activity
IM867_RS08490	COG3833	ABC-type maltose transport systems, permease component
IM867_RS08495	COG1175	transmembrane transport
IM867_RS08505	COG0366	Alpha amylase catalytic
IM867_RS08530	COG1420	regulation of RNA biosynthetic process
IM867_RS08535	COG0484	heat shock protein binding
IM867_RS08555	COG0537	adenosine 5'-monophosphoramidase activity
IM867_RS08565	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
IM867_RS08580	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
IM867_RS08585	COG1414	Transcriptional regulator
IM867_RS08590	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
IM867_RS08600	COG1381	Involved in DNA repair and RecF pathway recombination
IM867_RS08605	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
IM867_RS08625	COG1108	ABC-type Mn2 Zn2 transport systems permease components
IM867_RS08630	COG1121	(ABC) transporter
IM867_RS08645	COG0423	glycine-tRNA ligase activity
IM867_RS08650	COG1272	protein, Hemolysin III
IM867_RS08655	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
IM867_RS08655	COG0574	Belongs to the PEP-utilizing enzyme family
IM867_RS08665	COG0232	Belongs to the dGTPase family. Type 2 subfamily
IM867_RS08670	COG0358	DNA primase activity
IM867_RS08675	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
IM867_RS08710	COG0659	secondary active sulfate transmembrane transporter activity
IM867_RS08715	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
IM867_RS08725	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
IM867_RS08725	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
IM867_RS08755	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
IM867_RS08780	COG3546	catalase activity
IM867_RS08820	COG0859	PFAM glycosyl transferase family 9
IM867_RS08835	COG0438	transferase activity, transferring glycosyl groups
IM867_RS08880	COG1349	DNA-binding transcription factor activity
IM867_RS08900	COG0601	transmembrane transport
IM867_RS08905	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IM867_RS08910	COG0444	Belongs to the ABC transporter superfamily
IM867_RS08945	COG1522	sequence-specific DNA binding
IM867_RS08950	COG3483	tryptophan 2,3-dioxygenase activity
IM867_RS08980	COG0167	dihydroorotate dehydrogenase activity
IM867_RS09000	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
IM867_RS09005	COG2011	ABC-type metal ion transport system permease component
IM867_RS09010	COG1464	Belongs to the NlpA lipoprotein family
IM867_RS09025	COG0395	ABC-type sugar transport system, permease component
IM867_RS09030	COG2723	6-phospho-beta-galactosidase activity
IM867_RS09055	COG2018	Roadblock/LC7 domain
IM867_RS09070	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
IM867_RS09080	COG1960	acyl-CoA dehydrogenase activity
IM867_RS09090	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
IM867_RS09100	COG1252	NADH dehydrogenase
IM867_RS09110	COG1937	Protein conserved in bacteria
IM867_RS09150	COG4948	Mandelate Racemase Muconate Lactonizing
IM867_RS09155	COG0686	Belongs to the AlaDH PNT family
IM867_RS09160	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
IM867_RS09165	COG3336	cytochrome c oxidase
IM867_RS09265	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IM867_RS09270	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
IM867_RS09275	COG0174	glutamine synthetase
IM867_RS09280	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
IM867_RS09280	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
IM867_RS09295	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
IM867_RS09300	COG2076	Multidrug Resistance protein
IM867_RS09320	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
IM867_RS09325	COG0321	lipoyl(octanoyl) transferase activity
IM867_RS09330	COG0508	dehydrogenase complex catalyzes the overall conversion of
IM867_RS09335	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IM867_RS09340	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
IM867_RS09345	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
IM867_RS09360	COG4717	serine-type aminopeptidase activity
IM867_RS09365	COG0420	3'-5' exonuclease activity
IM867_RS09395	COG0667	Aldo Keto reductase
IM867_RS09415	COG0501	Belongs to the peptidase M48B family
IM867_RS09425	COG1929	Belongs to the glycerate kinase type-1 family
IM867_RS09435	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IM867_RS09440	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
IM867_RS09450	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
IM867_RS09455	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
IM867_RS09465	COG1376	ErfK ybiS ycfS ynhG family protein
IM867_RS09470	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
IM867_RS09475	COG0723	plastoquinol--plastocyanin reductase activity
IM867_RS09480	COG2010	Cytochrome c
IM867_RS09485	COG1845	cytochrome c oxidase, subunit III
IM867_RS09495	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
IM867_RS09525	COG0791	NLP P60 protein
IM867_RS09540	COG1940	carbohydrate kinase activity
IM867_RS09560	COG0205	6-phosphofructokinase activity
IM867_RS09565	COG0301	tRNA thio-modification
IM867_RS09570	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
IM867_RS09575	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
IM867_RS09580	COG2815	serine threonine protein kinase
IM867_RS09580	COG0515	serine threonine protein kinase
IM867_RS09585	COG2022	thiamine diphosphate biosynthetic process
IM867_RS09590	COG2104	thiamine diphosphate biosynthetic process
IM867_RS09595	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IM867_RS09595	COG2022	thiamine diphosphate biosynthetic process
IM867_RS09605	COG0352	thiamine-phosphate diphosphorylase activity
IM867_RS09620	COG0456	acetyltransferase
IM867_RS09630	COG0142	geranyltranstransferase activity
IM867_RS09640	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
IM867_RS09645	COG0540	Belongs to the ATCase OTCase family
IM867_RS09650	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
IM867_RS09655	COG0505	Belongs to the CarA family
IM867_RS09660	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
IM867_RS09665	COG0543	2 iron, 2 sulfur cluster binding
IM867_RS09670	COG0167	dihydroorotate dehydrogenase activity
IM867_RS09675	COG0284	orotidine-5'-phosphate decarboxylase activity
IM867_RS09685	COG0194	GDP metabolic process
IM867_RS09690	COG1758	RNA polymerase activity
IM867_RS09700	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
IM867_RS09705	COG2311	Membrane
IM867_RS09715	COG1960	acyl-CoA dehydrogenase activity
IM867_RS09740	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
IM867_RS09750	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
IM867_RS09760	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
IM867_RS09770	COG3201	nicotinamide mononucleotide transporter
IM867_RS09775	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
IM867_RS09775	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
IM867_RS09780	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
IM867_RS09795	COG2017	converts alpha-aldose to the beta-anomer
IM867_RS09800	COG2815	serine threonine protein kinase
IM867_RS09800	COG0515	serine threonine protein kinase
IM867_RS09815	COG1846	Transcriptional regulator
IM867_RS09830	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
IM867_RS09835	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
IM867_RS09840	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
IM867_RS09845	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
IM867_RS09850	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
IM867_RS09860	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
IM867_RS09870	COG1305	Transglutaminase-like
IM867_RS09880	COG0714	Associated with various cellular activities
IM867_RS09885	COG2001	Belongs to the MraZ family
IM867_RS09890	COG0275	rRNA processing
IM867_RS09900	COG0768	penicillin binding
IM867_RS09905	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
IM867_RS09915	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
IM867_RS09920	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
IM867_RS09930	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
IM867_RS09935	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
IM867_RS09945	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
IM867_RS09950	COG1496	oxidoreductase activity
IM867_RS09960	COG1799	cell septum assembly
IM867_RS09980	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
IM867_RS09990	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
IM867_RS10045	COG2318	DinB family
IM867_RS10050	COG0675	Transposase, IS605 OrfB family
IM867_RS10085	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IM867_RS10095	COG1132	(ABC) transporter
IM867_RS10125	COG1695	Transcriptional regulator
IM867_RS10140	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
IM867_RS10145	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
IM867_RS10150	COG0131	Imidazoleglycerol-phosphate dehydratase
IM867_RS10160	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
IM867_RS10165	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
IM867_RS10170	COG0107	imidazoleglycerol-phosphate synthase activity
IM867_RS10175	COG1132	(ABC) transporter
IM867_RS10180	COG1132	(ABC) transporter
IM867_RS10190	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
IM867_RS10215	COG0134	indole-3-glycerol-phosphate synthase activity
IM867_RS10220	COG0133	tryptophan synthase activity
IM867_RS10225	COG0159	tryptophan synthase activity
IM867_RS10240	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
IM867_RS10260	COG0070	glutamate synthase
IM867_RS10260	COG0067	glutamate synthase
IM867_RS10260	COG0069	glutamate synthase activity
IM867_RS10290	COG0047	phosphoribosylformylglycinamidine synthase activity
IM867_RS10345	COG2050	protein possibly involved in aromatic compounds catabolism
IM867_RS10360	COG0539	negative regulation of cytoplasmic translation
IM867_RS10365	COG0237	dephospho-CoA kinase activity
IM867_RS10370	COG1162	GTPase activity
IM867_RS10380	COG0556	nucleotide-excision repair
IM867_RS10395	COG0504	CTP synthase activity
IM867_RS10400	COG0494	nUDIX hydrolase
IM867_RS10420	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
IM867_RS10425	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
IM867_RS10445	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
IM867_RS10450	COG1160	GTP binding
IM867_RS10460	COG0483	inositol monophosphate 1-phosphatase activity
IM867_RS10475	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
IM867_RS10500	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
IM867_RS10520	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IM867_RS10525	COG1028	Short-chain dehydrogenase reductase Sdr
IM867_RS10530	COG2124	cytochrome p450
IM867_RS10545	COG4770	biotin carboxylase activity
IM867_RS10550	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
IM867_RS10555	COG2910	NAD(P)H-binding
IM867_RS10560	COG3321	synthase
IM867_RS10560	COG0604	alcohol dehydrogenase
IM867_RS10565	COG1309	transcriptional regulator
IM867_RS10575	COG1960	acyl-CoA dehydrogenase activity
IM867_RS10580	COG0702	epimerase
IM867_RS10595	COG0745	RESPONSE REGULATOR receiver
IM867_RS10605	COG0596	Alpha beta hydrolase
IM867_RS10660	COG4326	sporulation control protein
IM867_RS10680	COG0675	Transposase, IS605 OrfB family
IM867_RS10690	COG1024	Enoyl-CoA hydratase
IM867_RS10695	COG0110	maltose O-acetyltransferase activity
IM867_RS10710	COG1253	flavin adenine dinucleotide binding
IM867_RS10720	COG2084	Dehydrogenase
IM867_RS10725	COG2207	Transcriptional regulator
IM867_RS10725	COG3708	Transcriptional regulator
IM867_RS10730	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
IM867_RS10775	COG0604	alcohol dehydrogenase
IM867_RS10785	COG0183	Belongs to the thiolase family
IM867_RS10795	COG1024	Enoyl-CoA hydratase
IM867_RS10800	COG1960	acyl-CoA dehydrogenase activity
IM867_RS10805	COG1960	acyl-CoA dehydrogenase activity
IM867_RS10825	COG2030	dehydratase
IM867_RS10830	COG1012	belongs to the aldehyde dehydrogenase family
IM867_RS10835	COG1804	L-carnitine dehydratase bile acid-inducible protein F
IM867_RS10870	COG0477	Major facilitator Superfamily
IM867_RS10885	COG1028	Short-chain dehydrogenase reductase Sdr
IM867_RS10920	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
IM867_RS10925	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IM867_RS10960	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
IM867_RS10970	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
IM867_RS10970	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
IM867_RS10975	COG0431	NADPH-dependent FMN reductase
IM867_RS10985	COG5002	protein histidine kinase activity
IM867_RS10990	COG0745	RESPONSE REGULATOR receiver
IM867_RS11025	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
IM867_RS11055	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
IM867_RS11060	COG2815	serine threonine protein kinase
IM867_RS11060	COG0515	serine threonine protein kinase
IM867_RS11070	COG1285	pathogenesis
IM867_RS11075	COG3387	PFAM Glycoside hydrolase 15-related
IM867_RS11080	COG2364	Membrane
IM867_RS11085	COG2267	carboxylic ester hydrolase activity
IM867_RS11100	COG0515	serine threonine protein kinase
IM867_RS11145	COG3903	Transcriptional regulator
IM867_RS11145	COG3629	intracellular signal transduction
IM867_RS11150	COG1690	Belongs to the RtcB family
IM867_RS11200	COG0675	Transposase, IS605 OrfB family
IM867_RS11210	COG0746	molybdenum cofactor guanylyltransferase activity
IM867_RS11235	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
IM867_RS11240	COG1316	TRANSCRIPTIONal
IM867_RS11250	COG2186	Transcriptional regulator
IM867_RS11255	COG2807	transmembrane transport
IM867_RS11275	COG1960	acyl-CoA dehydrogenase activity
IM867_RS11300	COG0789	Transcriptional regulator
IM867_RS11310	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
IM867_RS11310	COG0512	Glutamine amidotransferase of anthranilate synthase
IM867_RS11325	COG1966	Carbon starvation protein
IM867_RS11335	COG0003	Pfam Anion-transporting ATPase
IM867_RS11340	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
IM867_RS11350	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
IM867_RS11370	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
IM867_RS11370	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
IM867_RS11380	COG1515	deoxyribonuclease V activity
IM867_RS11395	COG2197	response regulator
IM867_RS11425	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
IM867_RS11430	COG4948	Mandelate Racemase Muconate Lactonizing
IM867_RS11435	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
IM867_RS11440	COG0589	response to stress
IM867_RS11450	COG1649	PFAM Uncharacterised BCR, COG1649
IM867_RS11460	COG0768	penicillin binding
IM867_RS11500	COG5006	permease, DMT superfamily
IM867_RS11515	COG0598	Magnesium transport protein CorA
IM867_RS11640	COG2365	Tyrosine phosphatase family
IM867_RS11680	COG0714	Associated with various cellular activities
IM867_RS11690	COG3552	Protein containing von Willebrand factor type A (VWA) domain
IM867_RS11695	COG3458	cephalosporin-C deacetylase activity
IM867_RS11710	COG1960	acyl-CoA dehydrogenase activity
IM867_RS11715	COG2070	2-Nitropropane dioxygenase
IM867_RS11740	COG1028	Short-chain dehydrogenase reductase Sdr
IM867_RS11755	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
IM867_RS11775	COG1804	L-carnitine dehydratase bile acid-inducible protein F
IM867_RS11805	COG0657	acetylesterase activity
IM867_RS11820	COG2072	flavoprotein involved in K transport
IM867_RS11830	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IM867_RS11835	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IM867_RS11840	COG1120	ATPase activity
IM867_RS11865	COG0431	NADPH-dependent FMN reductase
IM867_RS11870	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IM867_RS11875	COG0745	RESPONSE REGULATOR receiver
IM867_RS11880	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IM867_RS11885	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IM867_RS11890	COG4521	taurine ABC transporter
IM867_RS11905	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
IM867_RS11905	COG2169	Transcriptional regulator
IM867_RS11930	COG1960	acyl-CoA dehydrogenase activity
IM867_RS11940	COG0515	serine threonine protein kinase
IM867_RS11940	COG2815	serine threonine protein kinase
IM867_RS11960	COG2233	PERMEase
IM867_RS11975	COG0183	Belongs to the thiolase family
IM867_RS11990	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
IM867_RS11990	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
IM867_RS12000	COG1234	tRNA 3'-trailer cleavage
IM867_RS12005	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
IM867_RS12010	COG0071	Belongs to the small heat shock protein (HSP20) family
IM867_RS12085	COG0508	dehydrogenase complex catalyzes the overall conversion of
IM867_RS12085	COG0596	Alpha beta hydrolase
IM867_RS12115	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
IM867_RS12170	COG3189	MarR family transcriptional regulator
IM867_RS12180	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
IM867_RS12180	COG2885	chlorophyll binding
IM867_RS12190	COG0492	ferredoxin-NADP+ reductase activity
IM867_RS12225	COG1070	Carbohydrate kinase
IM867_RS12270	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
IM867_RS12275	COG1518	maintenance of DNA repeat elements
IM867_RS12355	COG1070	Carbohydrate kinase
IM867_RS12360	COG1940	carbohydrate kinase activity
IM867_RS12370	COG1472	Belongs to the glycosyl hydrolase 3 family
IM867_RS12375	COG1940	carbohydrate kinase activity
IM867_RS12385	COG4209	transmembrane transport
IM867_RS12390	COG0395	ABC-type sugar transport system, permease component
IM867_RS12400	COG1501	Belongs to the glycosyl hydrolase 31 family
IM867_RS12425	COG1175	transmembrane transport
IM867_RS12430	COG1653	transport
IM867_RS12435	COG1609	Transcriptional regulator
IM867_RS12440	COG0726	polysaccharide deacetylase
IM867_RS12445	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IM867_RS12455	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
IM867_RS12460	COG0697	spore germination
IM867_RS12475	COG2855	membrane
IM867_RS12480	COG2723	6-phospho-beta-galactosidase activity
IM867_RS12505	COG4166	transmembrane transport
IM867_RS12515	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
IM867_RS12545	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IM867_RS12585	COG2323	membrane
IM867_RS12595	COG1090	epimerase
IM867_RS12600	COG2267	carboxylic ester hydrolase activity
IM867_RS12635	COG0579	oxidoreductase
IM867_RS12640	COG1108	ABC-type Mn2 Zn2 transport systems permease components
IM867_RS12645	COG1121	(ABC) transporter
IM867_RS12665	COG0512	Glutamine amidotransferase of anthranilate synthase
IM867_RS12665	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
IM867_RS12670	COG0789	Transcriptional regulator
IM867_RS12675	COG0477	Major facilitator Superfamily
IM867_RS12685	COG0477	Major facilitator Superfamily
IM867_RS12690	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IM867_RS12700	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
IM867_RS12710	COG3540	Alkaline phosphatase
IM867_RS12715	COG0667	Aldo Keto reductase
IM867_RS12725	COG0714	Associated with various cellular activities
IM867_RS12735	COG2304	oxidoreductase activity
IM867_RS12745	COG0494	nUDIX hydrolase
IM867_RS12755	COG1028	Short-chain dehydrogenase reductase Sdr
IM867_RS12760	COG2813	Specifically methylates the guanine in position
IM867_RS12765	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IM867_RS12770	COG1253	flavin adenine dinucleotide binding
IM867_RS12775	COG1253	flavin adenine dinucleotide binding
IM867_RS12785	COG1012	belongs to the aldehyde dehydrogenase family
IM867_RS12810	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IM867_RS12815	COG0730	response to heat
IM867_RS12820	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
IM867_RS12825	COG1132	(ABC) transporter
IM867_RS12830	COG2072	flavoprotein involved in K transport
IM867_RS12835	COG2267	carboxylic ester hydrolase activity
IM867_RS12840	COG1028	Short-chain dehydrogenase reductase Sdr
IM867_RS12845	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
IM867_RS12845	COG2755	lipolytic protein G-D-S-L family
IM867_RS12850	COG1653	transport
IM867_RS12855	COG0395	ABC-type sugar transport system, permease component
IM867_RS12860	COG1175	transmembrane transport
IM867_RS12865	COG0673	inositol 2-dehydrogenase activity
IM867_RS12895	COG1802	Transcriptional regulator
IM867_RS12915	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IM867_RS12920	COG2376	Dihydroxyacetone kinase
IM867_RS12925	COG4948	Mandelate Racemase Muconate Lactonizing
IM867_RS12930	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IM867_RS12945	COG0673	inositol 2-dehydrogenase activity
IM867_RS12970	COG0242	peptide deformylase activity
IM867_RS12980	COG2814	Major facilitator Superfamily
IM867_RS12985	COG0675	Transposase, IS605 OrfB family
IM867_RS13000	COG0463	Glycosyl transferase, family 2
IM867_RS13010	COG0463	Glycosyl transferase, family 2
IM867_RS13020	COG2814	Major facilitator Superfamily
IM867_RS13050	COG0583	DNA-binding transcription factor activity
IM867_RS13055	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
IM867_RS13060	COG1215	transferase activity, transferring glycosyl groups
IM867_RS13070	COG0006	proline dipeptidase activity
IM867_RS13105	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
IM867_RS13110	COG2264	protein methyltransferase activity
IM867_RS13120	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
IM867_RS13170	COG0815	Transfers the fatty acyl group on membrane lipoproteins
IM867_RS13175	COG3842	ATPase activity
IM867_RS13180	COG0438	transferase activity, transferring glycosyl groups
IM867_RS13185	COG4581	dead DEAH box helicase
IM867_RS13200	COG0805	protein transport
IM867_RS13205	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
IM867_RS13230	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
IM867_RS13240	COG1960	acyl-CoA dehydrogenase activity
IM867_RS13275	COG1028	Short-chain dehydrogenase reductase Sdr
IM867_RS13280	COG2186	Transcriptional regulator
IM867_RS13285	COG4948	Mandelate Racemase Muconate Lactonizing
IM867_RS13295	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
IM867_RS13300	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
IM867_RS13305	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
IM867_RS13325	COG0477	Major facilitator Superfamily
IM867_RS13335	COG4122	O-methyltransferase activity
IM867_RS13385	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
IM867_RS13390	COG1222	aaa ATPase
IM867_RS13420	COG1994	Peptidase M50
IM867_RS13420	COG0517	IMP dehydrogenase activity
IM867_RS13430	COG2197	response regulator
IM867_RS13455	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IM867_RS13465	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IM867_RS13470	COG1410	methionine synthase
IM867_RS13470	COG0646	methionine synthase
IM867_RS13495	COG0215	cysteine-tRNA ligase activity
IM867_RS13515	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
IM867_RS13530	COG0406	alpha-ribazole phosphatase activity
IM867_RS13535	COG1968	undecaprenyl-diphosphatase activity
IM867_RS13540	COG0667	Aldo Keto reductase
IM867_RS13550	COG1028	Short-chain dehydrogenase reductase Sdr
IM867_RS13555	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
IM867_RS13560	COG1028	Short-chain dehydrogenase reductase Sdr
IM867_RS13570	COG2197	response regulator
IM867_RS13575	COG4585	Histidine kinase
IM867_RS13580	COG1136	(ABC) transporter
IM867_RS13580	COG0577	efflux transmembrane transporter activity
IM867_RS13585	COG1136	(ABC) transporter
IM867_RS13585	COG0577	efflux transmembrane transporter activity
IM867_RS13625	COG1505	serine-type exopeptidase activity
IM867_RS13645	COG2375	cellular response to nickel ion
IM867_RS13655	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
IM867_RS13670	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
IM867_RS13685	COG3433	isochorismatase activity
IM867_RS13685	COG1535	isochorismatase
IM867_RS13700	COG1021	2,3-dihydroxybenzoate-AMP ligase
IM867_RS13705	COG1169	isochorismate synthase
IM867_RS13710	COG1028	Short-chain dehydrogenase reductase Sdr
IM867_RS13720	COG0701	Predicted permease
IM867_RS13725	COG2130	NADP-dependent
IM867_RS13735	COG1024	Enoyl-CoA hydratase
IM867_RS13745	COG0488	(ABC) transporter
IM867_RS13795	COG0175	sulfate reduction
IM867_RS13815	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
IM867_RS13820	COG0688	phosphatidylethanolamine metabolic process
IM867_RS13830	COG3253	May function as heme-dependent peroxidase
IM867_RS13845	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
IM867_RS13865	COG0183	Belongs to the thiolase family
IM867_RS13895	COG2409	Drug exporters of the RND superfamily
IM867_RS13920	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
IM867_RS13935	COG4214	carbohydrate transport
IM867_RS13945	COG4213	ABC transporter substrate-binding protein
IM867_RS13950	COG1940	carbohydrate kinase activity
IM867_RS13960	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
IM867_RS13965	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IM867_RS13970	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
IM867_RS13975	COG0569	domain protein
IM867_RS13985	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IM867_RS14010	COG0756	dUTP diphosphatase activity
IM867_RS14015	COG0525	valine-tRNA ligase activity
IM867_RS14035	COG2205	protein histidine kinase activity
IM867_RS14040	COG0745	RESPONSE REGULATOR receiver
IM867_RS14060	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
IM867_RS14115	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
IM867_RS14120	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
IM867_RS14135	COG5297	Belongs to the glycosyl hydrolase family 6
IM867_RS14135	COG4733	cellulase activity
IM867_RS14145	COG0009	L-threonylcarbamoyladenylate synthase
IM867_RS14180	COG0432	Pfam Uncharacterised protein family UPF0047
IM867_RS14190	COG1984	allophanate hydrolase subunit 2
IM867_RS14195	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
IM867_RS14200	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
IM867_RS14220	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
IM867_RS14225	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
IM867_RS14240	COG2755	lipolytic protein G-D-S-L family
IM867_RS14255	COG2151	metal-sulfur cluster biosynthetic enzyme
IM867_RS14270	COG0396	ATPase activity
IM867_RS14295	COG1131	(ABC) transporter
IM867_RS14310	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
IM867_RS14340	COG0318	PFAM AMP-dependent synthetase and ligase
IM867_RS14345	COG1960	acyl-CoA dehydrogenase activity
IM867_RS14350	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
IM867_RS14355	COG0109	protoheme IX farnesyltransferase activity
IM867_RS14365	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
IM867_RS14370	COG0166	Belongs to the GPI family
IM867_RS14385	COG0363	glucosamine-6-phosphate deaminase activity
IM867_RS14390	COG3401	FG-GAP repeat protein
IM867_RS14400	COG0531	amino acid
IM867_RS14415	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
IM867_RS14425	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
IM867_RS14430	COG1481	regulation of sporulation
IM867_RS14440	COG1660	Displays ATPase and GTPase activities
IM867_RS14445	COG0322	excinuclease ABC activity
IM867_RS14460	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
IM867_RS14495	COG0497	DNA recombination
IM867_RS14500	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
IM867_RS14525	COG0647	UMP catabolic process
IM867_RS14565	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
IM867_RS14600	COG2205	protein histidine kinase activity
IM867_RS14605	COG0165	Argininosuccinate lyase
IM867_RS14610	COG0137	argininosuccinate synthase activity
IM867_RS14615	COG1438	arginine binding
IM867_RS14620	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
IM867_RS14625	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
IM867_RS14630	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
IM867_RS14635	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
IM867_RS14640	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
IM867_RS14645	COG1846	Transcriptional regulator
IM867_RS14650	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IM867_RS14650	COG0072	phenylalanine-tRNA ligase activity
IM867_RS14655	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
IM867_RS14660	COG5002	protein histidine kinase activity
IM867_RS14665	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IM867_RS14670	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
IM867_RS14675	COG0291	Belongs to the bacterial ribosomal protein bL35 family
IM867_RS14680	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
IM867_RS14685	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
IM867_RS14695	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
IM867_RS14700	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
IM867_RS14715	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IM867_RS14715	COG0515	serine threonine protein kinase
IM867_RS14720	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IM867_RS14720	COG0515	serine threonine protein kinase
IM867_RS14775	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
IM867_RS14785	COG1196	nuclear chromosome segregation
IM867_RS14795	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
IM867_RS14800	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
IM867_RS14805	COG1862	Preprotein translocase
IM867_RS14810	COG2255	four-way junction helicase activity
IM867_RS14815	COG0632	four-way junction helicase activity
IM867_RS14820	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
IM867_RS14825	COG0217	transcriptional regulatory protein
IM867_RS14830	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
IM867_RS14835	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
IM867_RS14845	COG0438	transferase activity, transferring glycosyl groups
IM867_RS14855	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
IM867_RS14870	COG1253	flavin adenine dinucleotide binding
IM867_RS14880	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
IM867_RS14905	COG2018	Roadblock/LC7 domain
IM867_RS15010	COG0494	nUDIX hydrolase
IM867_RS15025	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
IM867_RS15060	COG1388	LysM domain
IM867_RS15060	COG3942	CHAP domain
IM867_RS15085	COG3265	gluconokinase activity
IM867_RS15115	COG1011	Hydrolase
IM867_RS15155	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IM867_RS15170	COG0045	succinate-CoA ligase (ADP-forming) activity
IM867_RS15185	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
IM867_RS15200	COG0187	DNA topoisomerase II activity
IM867_RS15210	COG3022	response to hydroperoxide
IM867_RS15225	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
IM867_RS15245	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
IM867_RS15250	COG0464	growth
IM867_RS15255	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
IM867_RS15275	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
IM867_RS15280	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
IM867_RS15285	COG1388	LysM domain
IM867_RS15290	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
IM867_RS15310	COG0495	leucyl-tRNA aminoacylation
IM867_RS15320	COG0318	PFAM AMP-dependent synthetase and ligase
IM867_RS15330	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
IM867_RS15340	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
IM867_RS15395	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
IM867_RS15400	COG0501	Belongs to the peptidase M48B family
IM867_RS15415	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
IM867_RS15425	COG0675	Transposase, IS605 OrfB family
IM867_RS15440	COG0438	transferase activity, transferring glycosyl groups
IM867_RS15445	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
IM867_RS15450	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
IM867_RS15455	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
IM867_RS15460	COG0211	Belongs to the bacterial ribosomal protein bL27 family
IM867_RS15465	COG0261	This protein binds to 23S rRNA in the presence of protein L20
IM867_RS15470	COG1530	ribonuclease E activity
IM867_RS15485	COG0772	Belongs to the SEDS family
IM867_RS15495	COG0105	UTP biosynthetic process
IM867_RS15505	COG0285	dihydrofolate synthase activity
IM867_RS15515	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
IM867_RS15520	COG0740	serine-type endopeptidase activity
IM867_RS15525	COG0740	serine-type endopeptidase activity
IM867_RS15530	COG0544	peptidyl-prolyl cis-trans isomerase activity
IM867_RS15545	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
IM867_RS15545	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
IM867_RS15550	COG1132	(ABC) transporter
IM867_RS15560	COG2239	Acts as a magnesium transporter
IM867_RS15570	COG4552	Acetyltransferase involved in intracellular survival and related
IM867_RS15575	COG0698	ribose 5-phosphate isomerase
IM867_RS15590	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
IM867_RS15620	COG0129	dihydroxy-acid dehydratase activity
IM867_RS15635	COG1505	serine-type exopeptidase activity
IM867_RS15645	COG2271	Major facilitator Superfamily
IM867_RS15670	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
IM867_RS15680	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
IM867_RS15680	COG1648	precorrin-2 dehydrogenase activity
IM867_RS15685	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
IM867_RS15715	COG0675	Transposase, IS605 OrfB family
IM867_RS15750	COG4585	Histidine kinase
IM867_RS15755	COG2197	response regulator
IM867_RS15760	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
IM867_RS15765	COG3766	membrane
IM867_RS15790	COG1522	sequence-specific DNA binding
IM867_RS15815	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
IM867_RS15825	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
IM867_RS15845	COG1115	amino acid carrier protein
IM867_RS15860	COG0583	DNA-binding transcription factor activity
IM867_RS15875	COG0438	transferase activity, transferring glycosyl groups
IM867_RS15905	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
IM867_RS15935	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
IM867_RS15955	COG2894	cell division
IM867_RS15985	COG2197	response regulator
IM867_RS16000	COG2885	chlorophyll binding
IM867_RS16010	COG0791	NLP P60 protein
IM867_RS16010	COG0741	lytic transglycosylase activity
IM867_RS16035	COG1192	Involved in chromosome partitioning
IM867_RS16060	COG0667	Aldo Keto reductase
IM867_RS16075	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IM867_RS16100	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
IM867_RS16105	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
IM867_RS16110	COG0569	domain protein
IM867_RS16140	COG1960	acyl-CoA dehydrogenase activity
IM867_RS16145	COG1960	acyl-CoA dehydrogenase activity
IM867_RS16155	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
IM867_RS16160	COG1122	ATPase activity
IM867_RS16165	COG1268	BioY protein
IM867_RS16170	COG2706	6-phosphogluconolactonase activity
IM867_RS16180	COG1643	Atp-dependent helicase
IM867_RS16220	COG1737	Transcriptional regulator
IM867_RS16225	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
IM867_RS16230	COG2949	membrane
IM867_RS16285	COG3395	kinase activity
IM867_RS16290	COG1653	transport
IM867_RS16295	COG1175	transmembrane transport
IM867_RS16300	COG0395	ABC-type sugar transport system, permease component
IM867_RS16310	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
IM867_RS16315	COG0784	Response regulator, receiver
IM867_RS16320	COG4251	negative regulation of phosphorylation
IM867_RS16330	COG5398	heme oxygenase
IM867_RS16355	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
IM867_RS16360	COG0404	The glycine cleavage system catalyzes the degradation of glycine
IM867_RS16365	COG0509	glycine decarboxylation via glycine cleavage system
IM867_RS16370	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
IM867_RS16415	COG2815	serine threonine protein kinase
IM867_RS16415	COG0515	serine threonine protein kinase