locus-tag	class	description
TFU_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
TFU_RS00010	COG0592	DNA-directed DNA polymerase activity
TFU_RS00015	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
TFU_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
TFU_RS00025	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
TFU_RS00030	COG0187	DNA topoisomerase II activity
TFU_RS00035	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
TFU_RS00055	COG2089	acid synthase
TFU_RS00060	COG1216	Glycosyl transferase, family 2
TFU_RS00085	COG1482	cell wall glycoprotein biosynthetic process
TFU_RS00090	COG1316	TRANSCRIPTIONal
TFU_RS00095	COG0305	Participates in initiation and elongation during chromosome replication
TFU_RS00140	COG0583	DNA-binding transcription factor activity
TFU_RS00150	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
TFU_RS00210	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
TFU_RS00215	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
TFU_RS00220	COG3387	PFAM Glycoside hydrolase 15-related
TFU_RS00225	COG0587	DNA-directed DNA polymerase activity
TFU_RS00235	COG1196	nuclear chromosome segregation
TFU_RS00285	COG0277	FAD linked oxidase domain protein
TFU_RS00290	COG1201	RNA secondary structure unwinding
TFU_RS00310	COG0210	DNA helicase
TFU_RS00330	COG1960	acyl-CoA dehydrogenase activity
TFU_RS00350	COG0604	alcohol dehydrogenase
TFU_RS00350	COG1028	Short-chain dehydrogenase reductase Sdr
TFU_RS00350	COG3321	synthase
TFU_RS00385	COG2267	carboxylic ester hydrolase activity
TFU_RS00395	COG1028	Short-chain dehydrogenase reductase Sdr
TFU_RS00405	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
TFU_RS00425	COG0592	DNA-directed DNA polymerase activity
TFU_RS00460	COG0039	L-malate dehydrogenase activity
TFU_RS00480	COG0384	phenazine biosynthesis protein PhzF
TFU_RS00500	COG2183	response to ionizing radiation
TFU_RS00530	COG1408	metallophosphoesterase
TFU_RS00540	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
TFU_RS00575	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TFU_RS00605	COG1366	Belongs to the anti-sigma-factor antagonist family
TFU_RS00610	COG1111	helicase
TFU_RS00610	COG1205	dead DEAH box helicase
TFU_RS00650	COG0596	Alpha beta hydrolase
TFU_RS00660	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
TFU_RS00665	COG0406	alpha-ribazole phosphatase activity
TFU_RS00670	COG3830	Belongs to the UPF0237 family
TFU_RS00670	COG0560	Phosphoserine phosphatase
TFU_RS00685	COG1119	ATPase activity
TFU_RS00705	COG1309	transcriptional regulator
TFU_RS00710	COG2843	Capsule synthesis protein
TFU_RS00755	COG3866	Pectate lyase
TFU_RS00765	COG0657	acetylesterase activity
TFU_RS00770	COG0047	phosphoribosylformylglycinamidine synthase activity
TFU_RS00780	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
TFU_RS00800	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
TFU_RS00830	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
TFU_RS00835	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
TFU_RS00850	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
TFU_RS00860	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
TFU_RS00865	COG0140	phosphoribosyl-ATP diphosphatase activity
TFU_RS00880	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
TFU_RS00885	COG1595	DNA-templated transcription, initiation
TFU_RS00895	COG0022	dehydrogenase e1 component
TFU_RS00900	COG0508	dehydrogenase complex catalyzes the overall conversion of
TFU_RS00915	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
TFU_RS00920	COG0706	membrane insertase activity
TFU_RS00935	COG0800	Aldolase
TFU_RS00970	COG2181	nitrate reductase activity
TFU_RS00970	COG0247	lactate metabolic process
TFU_RS00975	COG0443	Heat shock 70 kDa protein
TFU_RS00980	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
TFU_RS00985	COG0484	heat shock protein binding
TFU_RS00990	COG0789	Transcriptional regulator
TFU_RS00995	COG0542	response to heat
TFU_RS01020	COG2226	methyltransferase
TFU_RS01025	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
TFU_RS01030	COG3903	Transcriptional regulator
TFU_RS01030	COG3629	intracellular signal transduction
TFU_RS01045	COG1960	acyl-CoA dehydrogenase activity
TFU_RS01055	COG0215	cysteine-tRNA ligase activity
TFU_RS01060	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
TFU_RS01070	COG4974	Belongs to the 'phage' integrase family
TFU_RS01140	COG0459	protein refolding
TFU_RS01165	COG1278	Cold shock
TFU_RS01195	COG2252	PERMEase
TFU_RS01200	COG1846	Transcriptional regulator
TFU_RS01210	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
TFU_RS01220	COG0584	glycerophosphoryl diester phosphodiesterase
TFU_RS01235	COG0259	pyridoxamine-phosphate oxidase activity
TFU_RS01250	COG1295	ribonuclease BN
TFU_RS01250	COG1959	2 iron, 2 sulfur cluster binding
TFU_RS01260	COG0183	Belongs to the thiolase family
TFU_RS01275	COG2205	protein histidine kinase activity
TFU_RS01280	COG0745	RESPONSE REGULATOR receiver
TFU_RS01290	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
TFU_RS01335	COG2353	YceI-like domain
TFU_RS01340	COG0018	arginyl-trna synthetase
TFU_RS01350	COG0416	fatty acid biosynthetic process
TFU_RS01355	COG1509	lysine 2,3-aminomutase activity
TFU_RS01360	COG1940	carbohydrate kinase activity
TFU_RS01375	COG1024	Enoyl-CoA hydratase
TFU_RS01380	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
TFU_RS01385	COG1012	belongs to the aldehyde dehydrogenase family
TFU_RS01390	COG3842	ATPase activity
TFU_RS01400	COG1176	ABC-type spermidine putrescine transport system, permease component I
TFU_RS01405	COG1177	transmembrane transport
TFU_RS01410	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
TFU_RS01420	COG2205	protein histidine kinase activity
TFU_RS01420	COG3850	Histidine kinase
TFU_RS01420	COG4999	Histidine kinase
TFU_RS01420	COG3437	response regulator, receiver
TFU_RS01425	COG2208	phosphoserine phosphatase activity
TFU_RS01425	COG2770	Histidine kinase
TFU_RS01430	COG2197	response regulator
TFU_RS01435	COG4585	Histidine kinase
TFU_RS01465	COG0438	transferase activity, transferring glycosyl groups
TFU_RS01470	COG0631	protein serine/threonine phosphatase activity
TFU_RS01475	COG2372	response to copper ion
TFU_RS01485	COG0456	acetyltransferase
TFU_RS01495	COG1917	Cupin 2, conserved barrel domain protein
TFU_RS01505	COG0765	amino acid transport
TFU_RS01510	COG0765	amino acid transport
TFU_RS01515	COG1126	abc transporter atp-binding protein
TFU_RS01540	COG1797	cobyrinic acid a,c-diamide synthase activity
TFU_RS01600	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
TFU_RS01625	COG0725	ABC transporter, periplasmic molybdate-binding protein
TFU_RS01665	COG1120	ATPase activity
TFU_RS01670	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TFU_RS01675	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TFU_RS01690	COG2301	Belongs to the HpcH HpaI aldolase family
TFU_RS01700	COG0745	RESPONSE REGULATOR receiver
TFU_RS01710	COG1320	monovalent cation:proton antiporter activity
TFU_RS01715	COG2212	antiporter activity
TFU_RS01725	COG0651	ATP synthesis coupled electron transport
TFU_RS01730	COG1006	Multisubunit Na H antiporter MnhC subunit
TFU_RS01735	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
TFU_RS01735	COG2111	Na H antiporter
TFU_RS01740	COG1846	Transcriptional regulator
TFU_RS01750	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TFU_RS01770	COG0589	response to stress
TFU_RS01775	COG3384	dioxygenase
TFU_RS01780	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
TFU_RS01790	COG1028	Short-chain dehydrogenase reductase Sdr
TFU_RS01830	COG1876	peptidase activity
TFU_RS01845	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
TFU_RS01850	COG1210	Utp--glucose-1-phosphate uridylyltransferase
TFU_RS01860	COG0315	cyclic pyranopterin monophosphate synthase activity
TFU_RS01865	COG0315	cyclic pyranopterin monophosphate synthase activity
TFU_RS01865	COG0521	Mo-molybdopterin cofactor biosynthetic process
TFU_RS01870	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
TFU_RS01895	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
TFU_RS01925	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
TFU_RS01935	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TFU_RS01975	COG0084	hydrolase, TatD family'
TFU_RS01980	COG1804	L-carnitine dehydratase bile acid-inducible protein F
TFU_RS01995	COG2255	four-way junction helicase activity
TFU_RS02010	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
TFU_RS02020	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
TFU_RS02030	COG0488	(ABC) transporter
TFU_RS02060	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
TFU_RS02065	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
TFU_RS02070	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
TFU_RS02075	COG0193	aminoacyl-tRNA hydrolase activity
TFU_RS02080	COG1218	3'(2'),5'-bisphosphate nucleotidase
TFU_RS02100	COG1959	2 iron, 2 sulfur cluster binding
TFU_RS02115	COG0529	Catalyzes the synthesis of activated sulfate
TFU_RS02130	COG0148	phosphopyruvate hydratase activity
TFU_RS02150	COG1252	NADH dehydrogenase
TFU_RS02160	COG1012	belongs to the aldehyde dehydrogenase family
TFU_RS02165	COG0506	proline dehydrogenase activity
TFU_RS02175	COG0183	Belongs to the thiolase family
TFU_RS02180	COG2755	lipolytic protein G-D-S-L family
TFU_RS02190	COG0110	maltose O-acetyltransferase activity
TFU_RS02210	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
TFU_RS02225	COG1714	RDD family
TFU_RS02230	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
TFU_RS02240	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
TFU_RS02250	COG1331	Highly conserved protein containing a thioredoxin domain
TFU_RS02265	COG2815	serine threonine protein kinase
TFU_RS02265	COG0515	serine threonine protein kinase
TFU_RS02270	COG1595	DNA-templated transcription, initiation
TFU_RS02275	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
TFU_RS02280	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
TFU_RS02290	COG0114	fumarate hydratase activity
TFU_RS02330	COG1722	exodeoxyribonuclease VII activity
TFU_RS02335	COG1570	exodeoxyribonuclease VII activity
TFU_RS02350	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
TFU_RS02360	COG0012	GTP binding
TFU_RS02380	COG2255	four-way junction helicase activity
TFU_RS02425	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
TFU_RS02435	COG1994	Peptidase M50
TFU_RS02465	COG2171	N-acyltransferase activity
TFU_RS02470	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
TFU_RS02475	COG1611	Belongs to the LOG family
TFU_RS02485	COG2818	Glycosylase
TFU_RS02500	COG1024	Enoyl-CoA hydratase
TFU_RS02505	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
TFU_RS02510	COG1595	DNA-templated transcription, initiation
TFU_RS02525	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TFU_RS02545	COG0613	PHP domain protein
TFU_RS02560	COG0513	Belongs to the DEAD box helicase family
TFU_RS02605	COG0210	DNA helicase
TFU_RS02620	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
TFU_RS02645	COG1946	Acyl-CoA thioesterase
TFU_RS02685	COG3480	Lon protease (S16) C-terminal proteolytic domain
TFU_RS02695	COG1615	UPF0182 protein
TFU_RS02710	COG0483	inositol monophosphate 1-phosphatase activity
TFU_RS02715	COG1162	GTPase activity
TFU_RS02720	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
TFU_RS02730	COG2135	peptidase activity
TFU_RS02735	COG2226	methyltransferase
TFU_RS02740	COG1595	DNA-templated transcription, initiation
TFU_RS02745	COG5662	AntiSigma factor
TFU_RS02750	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
TFU_RS02750	COG2199	diguanylate cyclase activity
TFU_RS02770	COG2188	Transcriptional regulator
TFU_RS02785	COG1597	lipid kinase activity
TFU_RS02800	COG2172	sigma factor antagonist activity
TFU_RS02810	COG0281	malic enzyme
TFU_RS02825	COG0508	dehydrogenase complex catalyzes the overall conversion of
TFU_RS02825	COG0567	Dehydrogenase, E1 component
TFU_RS02845	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
TFU_RS02855	COG0500	methyltransferase
TFU_RS02870	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
TFU_RS02880	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
TFU_RS02885	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
TFU_RS02890	COG0616	signal peptide processing
TFU_RS02905	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
TFU_RS02915	COG0366	Alpha amylase catalytic
TFU_RS02920	COG0366	Alpha amylase catalytic
TFU_RS02925	COG0058	SHG alpha-glucan phosphorylase activity
TFU_RS02935	COG1122	ATPase activity
TFU_RS02940	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
TFU_RS02965	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
TFU_RS02980	COG0482	sulfurtransferase activity
TFU_RS03010	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
TFU_RS03020	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
TFU_RS03025	COG0154	amidase activity
TFU_RS03040	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
TFU_RS03045	COG5001	Diguanylate cyclase
TFU_RS03045	COG3300	MHYT domain
TFU_RS03060	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
TFU_RS03065	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
TFU_RS03070	COG0473	3-isopropylmalate dehydrogenase activity
TFU_RS03075	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
TFU_RS03080	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
TFU_RS03095	COG5297	Belongs to the glycosyl hydrolase family 6
TFU_RS03100	COG0179	Fumarylacetoacetate (FAA) hydrolase
TFU_RS03105	COG2311	Membrane
TFU_RS03110	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
TFU_RS03135	COG1414	Transcriptional regulator
TFU_RS03140	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
TFU_RS03145	COG0066	3-isopropylmalate dehydratase activity
TFU_RS03155	COG1920	GTP binding
TFU_RS03165	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
TFU_RS03175	COG1181	Belongs to the D-alanine--D-alanine ligase family
TFU_RS03185	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
TFU_RS03190	COG4988	ABC transporter
TFU_RS03195	COG1294	oxidase, subunit
TFU_RS03200	COG1271	oxidase subunit
TFU_RS03235	COG0227	Belongs to the bacterial ribosomal protein bL28 family
TFU_RS03240	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
TFU_RS03245	COG0742	ribosomal rna small subunit methyltransferase
TFU_RS03250	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
TFU_RS03260	COG0571	ribonuclease III activity
TFU_RS03265	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
TFU_RS03280	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
TFU_RS03285	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TFU_RS03290	COG0552	protein localization to endoplasmic reticulum
TFU_RS03310	COG0228	four-way junction DNA binding
TFU_RS03315	COG1837	Belongs to the UPF0109 family
TFU_RS03320	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
TFU_RS03325	COG0336	Belongs to the RNA methyltransferase TrmD family
TFU_RS03330	COG0335	large ribosomal subunit rRNA binding
TFU_RS03345	COG0792	nuclease activity
TFU_RS03370	COG4974	Belongs to the 'phage' integrase family
TFU_RS03380	COG0052	Belongs to the universal ribosomal protein uS2 family
TFU_RS03385	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
TFU_RS03390	COG0528	UMP kinase activity
TFU_RS03395	COG0233	cytoplasmic translational termination
TFU_RS03415	COG0820	rRNA (adenine-C2-)-methyltransferase activity
TFU_RS03420	COG1522	sequence-specific DNA binding
TFU_RS03430	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
TFU_RS03480	COG1105	Belongs to the carbohydrate kinase PfkB family
TFU_RS03550	COG1201	RNA secondary structure unwinding
TFU_RS03565	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
TFU_RS03565	COG0758	DNA mediated transformation
TFU_RS03605	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
TFU_RS03660	COG2226	methyltransferase
TFU_RS03680	COG0635	Involved in the biosynthesis of porphyrin-containing compound
TFU_RS03695	COG2885	chlorophyll binding
TFU_RS03705	COG1012	belongs to the aldehyde dehydrogenase family
TFU_RS03725	COG0750	zinc metalloprotease
TFU_RS03730	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
TFU_RS03740	COG0454	-acetyltransferase
TFU_RS03740	COG0456	acetyltransferase
TFU_RS03750	COG1653	transport
TFU_RS03780	COG0124	histidyl-tRNA synthetase
TFU_RS03790	COG0653	protein targeting
TFU_RS03810	COG1294	oxidase, subunit
TFU_RS03815	COG1271	oxidase subunit
TFU_RS03820	COG2197	response regulator
TFU_RS03825	COG4585	Histidine kinase
TFU_RS03830	COG0697	spore germination
TFU_RS03845	COG0442	prolyl-tRNA aminoacylation
TFU_RS03860	COG0779	Required for maturation of 30S ribosomal subunits
TFU_RS03870	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
TFU_RS03880	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
TFU_RS03885	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
TFU_RS03895	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
TFU_RS03900	COG1185	polyribonucleotide nucleotidyltransferase activity
TFU_RS03905	COG0612	Peptidase, M16
TFU_RS03910	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
TFU_RS03915	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
TFU_RS03930	COG1950	PFAM Membrane protein of
TFU_RS03935	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
TFU_RS03940	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
TFU_RS03945	COG1674	ftsk spoiiie
TFU_RS03955	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TFU_RS03965	COG1546	Belongs to the CinA family
TFU_RS03965	COG1058	Belongs to the CinA family
TFU_RS03970	COG1396	sequence-specific DNA binding
TFU_RS03995	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
TFU_RS03995	COG1372	Participates in initiation and elongation during chromosome replication
TFU_RS03995	COG1372	Participates in initiation and elongation during chromosome replication
TFU_RS03995	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
TFU_RS04000	COG2137	regulation of response to DNA damage stimulus
TFU_RS04005	COG1566	PFAM secretion protein HlyD family protein
TFU_RS04005	COG1418	mRNA catabolic process
TFU_RS04015	COG0765	amino acid transport
TFU_RS04020	COG0765	amino acid transport
TFU_RS04025	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
TFU_RS04030	COG1126	abc transporter atp-binding protein
TFU_RS04035	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TFU_RS04055	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
TFU_RS04060	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
TFU_RS04075	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
TFU_RS04080	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
TFU_RS04085	COG1228	amidohydrolase
TFU_RS04105	COG0658	competence protein
TFU_RS04105	COG2333	competence protein COMEC
TFU_RS04115	COG0268	Binds directly to 16S ribosomal RNA
TFU_RS04125	COG0481	GTPase activity
TFU_RS04130	COG3833	ABC-type maltose transport systems, permease component
TFU_RS04135	COG1175	transmembrane transport
TFU_RS04145	COG0366	Alpha amylase catalytic
TFU_RS04170	COG1420	regulation of RNA biosynthetic process
TFU_RS04175	COG0484	heat shock protein binding
TFU_RS04195	COG0537	adenosine 5'-monophosphoramidase activity
TFU_RS04205	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
TFU_RS04220	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
TFU_RS04225	COG1414	Transcriptional regulator
TFU_RS04230	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
TFU_RS04235	COG2340	Cysteine-rich secretory protein family
TFU_RS04240	COG1381	Involved in DNA repair and RecF pathway recombination
TFU_RS04245	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
TFU_RS04265	COG1108	ABC-type Mn2 Zn2 transport systems permease components
TFU_RS04270	COG1121	(ABC) transporter
TFU_RS04285	COG0423	glycine-tRNA ligase activity
TFU_RS04290	COG1272	protein, Hemolysin III
TFU_RS04295	COG0574	Belongs to the PEP-utilizing enzyme family
TFU_RS04295	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
TFU_RS04305	COG0232	Belongs to the dGTPase family. Type 2 subfamily
TFU_RS04310	COG0358	DNA primase activity
TFU_RS04315	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
TFU_RS04350	COG0659	secondary active sulfate transmembrane transporter activity
TFU_RS04355	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
TFU_RS04365	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
TFU_RS04365	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
TFU_RS04395	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
TFU_RS04420	COG3546	catalase activity
TFU_RS04460	COG0859	PFAM glycosyl transferase family 9
TFU_RS04475	COG0438	transferase activity, transferring glycosyl groups
TFU_RS04520	COG1349	DNA-binding transcription factor activity
TFU_RS04540	COG0601	transmembrane transport
TFU_RS04545	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TFU_RS04550	COG0444	Belongs to the ABC transporter superfamily
TFU_RS04585	COG1522	sequence-specific DNA binding
TFU_RS04590	COG3483	tryptophan 2,3-dioxygenase activity
TFU_RS04620	COG0167	dihydroorotate dehydrogenase activity
TFU_RS04640	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
TFU_RS04645	COG2011	ABC-type metal ion transport system permease component
TFU_RS04650	COG1464	Belongs to the NlpA lipoprotein family
TFU_RS04665	COG0395	ABC-type sugar transport system, permease component
TFU_RS04670	COG2723	6-phospho-beta-galactosidase activity
TFU_RS04695	COG2018	Roadblock/LC7 domain
TFU_RS04705	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
TFU_RS04715	COG1960	acyl-CoA dehydrogenase activity
TFU_RS04725	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
TFU_RS04735	COG1252	NADH dehydrogenase
TFU_RS04745	COG1937	Protein conserved in bacteria
TFU_RS04790	COG0686	Belongs to the AlaDH PNT family
TFU_RS04795	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
TFU_RS04800	COG3336	cytochrome c oxidase
TFU_RS04895	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
TFU_RS04900	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
TFU_RS04905	COG0174	glutamine synthetase
TFU_RS04910	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
TFU_RS04910	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
TFU_RS04925	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
TFU_RS04930	COG2076	Multidrug Resistance protein
TFU_RS04950	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
TFU_RS04955	COG0321	lipoyl(octanoyl) transferase activity
TFU_RS04960	COG0508	dehydrogenase complex catalyzes the overall conversion of
TFU_RS04965	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
TFU_RS04970	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
TFU_RS04975	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
TFU_RS04995	COG0420	3'-5' exonuclease activity
TFU_RS05015	COG0667	Aldo Keto reductase
TFU_RS05035	COG0501	Belongs to the peptidase M48B family
TFU_RS05045	COG1929	Belongs to the glycerate kinase type-1 family
TFU_RS05055	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
TFU_RS05060	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
TFU_RS05070	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
TFU_RS05075	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
TFU_RS05085	COG1376	ErfK ybiS ycfS ynhG family protein
TFU_RS05090	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
TFU_RS05095	COG0723	plastoquinol--plastocyanin reductase activity
TFU_RS05100	COG2010	Cytochrome c
TFU_RS05105	COG1845	cytochrome c oxidase, subunit III
TFU_RS05115	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
TFU_RS05145	COG0791	NLP P60 protein
TFU_RS05160	COG1940	carbohydrate kinase activity
TFU_RS05180	COG0205	6-phosphofructokinase activity
TFU_RS05185	COG0301	tRNA thio-modification
TFU_RS05190	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
TFU_RS05195	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
TFU_RS05200	COG0515	serine threonine protein kinase
TFU_RS05200	COG2815	serine threonine protein kinase
TFU_RS05205	COG2022	thiamine diphosphate biosynthetic process
TFU_RS05210	COG2104	thiamine diphosphate biosynthetic process
TFU_RS05215	COG2022	thiamine diphosphate biosynthetic process
TFU_RS05215	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
TFU_RS05225	COG0352	thiamine-phosphate diphosphorylase activity
TFU_RS05240	COG0456	acetyltransferase
TFU_RS05250	COG0142	geranyltranstransferase activity
TFU_RS05260	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
TFU_RS05265	COG0540	Belongs to the ATCase OTCase family
TFU_RS05270	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
TFU_RS05275	COG0505	Belongs to the CarA family
TFU_RS05280	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
TFU_RS05285	COG0543	2 iron, 2 sulfur cluster binding
TFU_RS05290	COG0167	dihydroorotate dehydrogenase activity
TFU_RS05295	COG0284	orotidine-5'-phosphate decarboxylase activity
TFU_RS05305	COG0194	GDP metabolic process
TFU_RS05310	COG1758	RNA polymerase activity
TFU_RS05320	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
TFU_RS05325	COG2311	Membrane
TFU_RS05335	COG1960	acyl-CoA dehydrogenase activity
TFU_RS05360	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
TFU_RS05370	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
TFU_RS05380	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
TFU_RS05390	COG3201	nicotinamide mononucleotide transporter
TFU_RS05395	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
TFU_RS05395	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
TFU_RS05400	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
TFU_RS05410	COG2017	converts alpha-aldose to the beta-anomer
TFU_RS05415	COG2815	serine threonine protein kinase
TFU_RS05415	COG0515	serine threonine protein kinase
TFU_RS05430	COG1846	Transcriptional regulator
TFU_RS05445	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
TFU_RS05450	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
TFU_RS05455	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
TFU_RS05460	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
TFU_RS05465	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
TFU_RS05475	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
TFU_RS05485	COG1305	Transglutaminase-like
TFU_RS05495	COG0714	Associated with various cellular activities
TFU_RS05500	COG2001	Belongs to the MraZ family
TFU_RS05505	COG0275	rRNA processing
TFU_RS05515	COG0768	penicillin binding
TFU_RS05520	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
TFU_RS05530	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
TFU_RS05535	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
TFU_RS05545	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
TFU_RS05550	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
TFU_RS05560	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
TFU_RS05565	COG1496	oxidoreductase activity
TFU_RS05575	COG1799	cell septum assembly
TFU_RS05595	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
TFU_RS05605	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
TFU_RS05655	COG2318	DinB family
TFU_RS05660	COG0675	Transposase, IS605 OrfB family
TFU_RS05695	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
TFU_RS05705	COG1132	(ABC) transporter
TFU_RS05730	COG1695	Transcriptional regulator
TFU_RS05745	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
TFU_RS05750	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
TFU_RS05755	COG0131	Imidazoleglycerol-phosphate dehydratase
TFU_RS05765	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
TFU_RS05770	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
TFU_RS05775	COG0107	imidazoleglycerol-phosphate synthase activity
TFU_RS05780	COG1132	(ABC) transporter
TFU_RS05785	COG1132	(ABC) transporter
TFU_RS05795	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
TFU_RS05820	COG0134	indole-3-glycerol-phosphate synthase activity
TFU_RS05825	COG0133	tryptophan synthase activity
TFU_RS05830	COG0159	tryptophan synthase activity
TFU_RS05845	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
TFU_RS05865	COG0070	glutamate synthase
TFU_RS05865	COG0069	glutamate synthase activity
TFU_RS05865	COG0067	glutamate synthase
TFU_RS05890	COG0047	phosphoribosylformylglycinamidine synthase activity
TFU_RS05945	COG2050	protein possibly involved in aromatic compounds catabolism
TFU_RS05960	COG0539	negative regulation of cytoplasmic translation
TFU_RS05965	COG0237	dephospho-CoA kinase activity
TFU_RS05970	COG1162	GTPase activity
TFU_RS05980	COG0556	nucleotide-excision repair
TFU_RS05995	COG0504	CTP synthase activity
TFU_RS06000	COG0494	nUDIX hydrolase
TFU_RS06020	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
TFU_RS06025	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
TFU_RS06045	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
TFU_RS06050	COG1160	GTP binding
TFU_RS06060	COG0483	inositol monophosphate 1-phosphatase activity
TFU_RS06075	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
TFU_RS06095	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
TFU_RS06120	COG1028	Short-chain dehydrogenase reductase Sdr
TFU_RS06125	COG2124	cytochrome p450
TFU_RS06140	COG4770	biotin carboxylase activity
TFU_RS06145	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
TFU_RS06150	COG2910	NAD(P)H-binding
TFU_RS06155	COG0604	alcohol dehydrogenase
TFU_RS06155	COG3321	synthase
TFU_RS06160	COG1309	transcriptional regulator
TFU_RS06170	COG1960	acyl-CoA dehydrogenase activity
TFU_RS06175	COG0702	epimerase
TFU_RS06190	COG0745	RESPONSE REGULATOR receiver
TFU_RS06200	COG0596	Alpha beta hydrolase
TFU_RS06255	COG4326	sporulation control protein
TFU_RS06275	COG1024	Enoyl-CoA hydratase
TFU_RS06280	COG0110	maltose O-acetyltransferase activity
TFU_RS06295	COG1253	flavin adenine dinucleotide binding
TFU_RS06305	COG2084	Dehydrogenase
TFU_RS06310	COG2207	Transcriptional regulator
TFU_RS06310	COG3708	Transcriptional regulator
TFU_RS06315	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
TFU_RS06360	COG0604	alcohol dehydrogenase
TFU_RS06370	COG0183	Belongs to the thiolase family
TFU_RS06380	COG1024	Enoyl-CoA hydratase
TFU_RS06385	COG1960	acyl-CoA dehydrogenase activity
TFU_RS06390	COG1960	acyl-CoA dehydrogenase activity
TFU_RS06410	COG2030	dehydratase
TFU_RS06415	COG1012	belongs to the aldehyde dehydrogenase family
TFU_RS06420	COG1804	L-carnitine dehydratase bile acid-inducible protein F
TFU_RS06455	COG0477	Major facilitator Superfamily
TFU_RS06470	COG1028	Short-chain dehydrogenase reductase Sdr
TFU_RS06505	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
TFU_RS06510	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
TFU_RS06520	COG3842	ATPase activity
TFU_RS06525	COG1840	ABC-type Fe3 transport system, periplasmic component
TFU_RS06550	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
TFU_RS06560	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
TFU_RS06560	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
TFU_RS06590	COG0675	Transposase, IS605 OrfB family
TFU_RS06600	COG0431	NADPH-dependent FMN reductase
TFU_RS06605	COG5002	protein histidine kinase activity
TFU_RS06610	COG0745	RESPONSE REGULATOR receiver
TFU_RS06640	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
TFU_RS06660	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
TFU_RS06665	COG0515	serine threonine protein kinase
TFU_RS06665	COG2815	serine threonine protein kinase
TFU_RS06675	COG1285	pathogenesis
TFU_RS06680	COG3387	PFAM Glycoside hydrolase 15-related
TFU_RS06685	COG2364	Membrane
TFU_RS06690	COG2267	carboxylic ester hydrolase activity
TFU_RS06695	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
TFU_RS06715	COG3119	arylsulfatase activity
TFU_RS06730	COG1690	Belongs to the RtcB family
TFU_RS06755	COG1690	Belongs to the RtcB family
TFU_RS06770	COG0456	acetyltransferase
TFU_RS06775	COG0746	molybdenum cofactor guanylyltransferase activity
TFU_RS06800	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
TFU_RS06805	COG1316	TRANSCRIPTIONal
TFU_RS06815	COG2186	Transcriptional regulator
TFU_RS06820	COG2807	transmembrane transport
TFU_RS06840	COG1960	acyl-CoA dehydrogenase activity
TFU_RS06865	COG0789	Transcriptional regulator
TFU_RS06875	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
TFU_RS06875	COG0512	Glutamine amidotransferase of anthranilate synthase
TFU_RS06890	COG1966	Carbon starvation protein
TFU_RS06900	COG0003	Pfam Anion-transporting ATPase
TFU_RS06905	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
TFU_RS06915	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
TFU_RS06935	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
TFU_RS06935	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
TFU_RS06945	COG1515	deoxyribonuclease V activity
TFU_RS06960	COG2197	response regulator
TFU_RS06990	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
TFU_RS06995	COG4948	Mandelate Racemase Muconate Lactonizing
TFU_RS07000	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
TFU_RS07005	COG0589	response to stress
TFU_RS07015	COG1649	PFAM Uncharacterised BCR, COG1649
TFU_RS07025	COG0768	penicillin binding
TFU_RS07065	COG5006	permease, DMT superfamily
TFU_RS07080	COG0598	Magnesium transport protein CorA
TFU_RS07195	COG2365	Tyrosine phosphatase family
TFU_RS07235	COG0714	Associated with various cellular activities
TFU_RS07245	COG3552	Protein containing von Willebrand factor type A (VWA) domain
TFU_RS07250	COG3458	cephalosporin-C deacetylase activity
TFU_RS07265	COG1960	acyl-CoA dehydrogenase activity
TFU_RS07270	COG2070	2-Nitropropane dioxygenase
TFU_RS07295	COG1028	Short-chain dehydrogenase reductase Sdr
TFU_RS07310	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
TFU_RS07330	COG1804	L-carnitine dehydratase bile acid-inducible protein F
TFU_RS07360	COG0657	acetylesterase activity
TFU_RS07375	COG2072	flavoprotein involved in K transport
TFU_RS07385	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TFU_RS07390	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TFU_RS07395	COG1120	ATPase activity
TFU_RS07420	COG0431	NADPH-dependent FMN reductase
TFU_RS07425	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
TFU_RS07430	COG0745	RESPONSE REGULATOR receiver
TFU_RS07435	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
TFU_RS07440	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
TFU_RS07445	COG4521	taurine ABC transporter
TFU_RS07460	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
TFU_RS07460	COG2169	Transcriptional regulator
TFU_RS07485	COG1960	acyl-CoA dehydrogenase activity
TFU_RS07495	COG2815	serine threonine protein kinase
TFU_RS07495	COG0515	serine threonine protein kinase
TFU_RS07515	COG2233	PERMEase
TFU_RS07525	COG0183	Belongs to the thiolase family
TFU_RS07545	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
TFU_RS07545	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
TFU_RS07555	COG1234	tRNA 3'-trailer cleavage
TFU_RS07560	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
TFU_RS07565	COG0071	Belongs to the small heat shock protein (HSP20) family
TFU_RS07625	COG0596	Alpha beta hydrolase
TFU_RS07625	COG0508	dehydrogenase complex catalyzes the overall conversion of
TFU_RS07655	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TFU_RS07690	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
TFU_RS07695	COG0798	PFAM Bile acid sodium symporter
TFU_RS07700	COG0640	Transcriptional regulator
TFU_RS07725	COG3189	MarR family transcriptional regulator
TFU_RS07735	COG2885	chlorophyll binding
TFU_RS07735	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
TFU_RS07745	COG0492	ferredoxin-NADP+ reductase activity
TFU_RS07785	COG1070	Carbohydrate kinase
TFU_RS07830	COG1518	maintenance of DNA repeat elements
TFU_RS07905	COG1070	Carbohydrate kinase
TFU_RS07910	COG1940	carbohydrate kinase activity
TFU_RS07920	COG1472	Belongs to the glycosyl hydrolase 3 family
TFU_RS07925	COG1940	carbohydrate kinase activity
TFU_RS07935	COG4209	transmembrane transport
TFU_RS07940	COG0395	ABC-type sugar transport system, permease component
TFU_RS07950	COG1501	Belongs to the glycosyl hydrolase 31 family
TFU_RS07975	COG1175	transmembrane transport
TFU_RS07980	COG1653	transport
TFU_RS07985	COG1609	Transcriptional regulator
TFU_RS07990	COG0726	polysaccharide deacetylase
TFU_RS07995	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
TFU_RS08005	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
TFU_RS08010	COG0697	spore germination
TFU_RS08025	COG2855	membrane
TFU_RS08030	COG2723	6-phospho-beta-galactosidase activity
TFU_RS08050	COG4166	transmembrane transport
TFU_RS08060	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
TFU_RS08090	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
TFU_RS08130	COG2323	membrane
TFU_RS08140	COG1090	epimerase
TFU_RS08145	COG2267	carboxylic ester hydrolase activity
TFU_RS08175	COG0579	oxidoreductase
TFU_RS08180	COG1108	ABC-type Mn2 Zn2 transport systems permease components
TFU_RS08185	COG1121	(ABC) transporter
TFU_RS08205	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
TFU_RS08205	COG0512	Glutamine amidotransferase of anthranilate synthase
TFU_RS08210	COG0789	Transcriptional regulator
TFU_RS08215	COG0477	Major facilitator Superfamily
TFU_RS08220	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
TFU_RS08230	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
TFU_RS08240	COG3540	Alkaline phosphatase
TFU_RS08245	COG0667	Aldo Keto reductase
TFU_RS08255	COG0714	Associated with various cellular activities
TFU_RS08265	COG2304	oxidoreductase activity
TFU_RS08275	COG0494	nUDIX hydrolase
TFU_RS08285	COG1028	Short-chain dehydrogenase reductase Sdr
TFU_RS08290	COG2813	Specifically methylates the guanine in position
TFU_RS08295	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
TFU_RS08300	COG1253	flavin adenine dinucleotide binding
TFU_RS08305	COG1253	flavin adenine dinucleotide binding
TFU_RS08315	COG1012	belongs to the aldehyde dehydrogenase family
TFU_RS08340	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
TFU_RS08345	COG0730	response to heat
TFU_RS08350	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
TFU_RS08355	COG1132	(ABC) transporter
TFU_RS08360	COG2072	flavoprotein involved in K transport
TFU_RS08365	COG2267	carboxylic ester hydrolase activity
TFU_RS08370	COG1028	Short-chain dehydrogenase reductase Sdr
TFU_RS08375	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
TFU_RS08375	COG2755	lipolytic protein G-D-S-L family
TFU_RS08380	COG1653	transport
TFU_RS08385	COG0395	ABC-type sugar transport system, permease component
TFU_RS08390	COG1175	transmembrane transport
TFU_RS08395	COG0673	inositol 2-dehydrogenase activity
TFU_RS08425	COG1802	Transcriptional regulator
TFU_RS08445	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
TFU_RS08450	COG2376	Dihydroxyacetone kinase
TFU_RS08455	COG4948	Mandelate Racemase Muconate Lactonizing
TFU_RS08460	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
TFU_RS08475	COG0673	inositol 2-dehydrogenase activity
TFU_RS08500	COG0242	peptide deformylase activity
TFU_RS08510	COG2814	Major facilitator Superfamily
TFU_RS08520	COG0463	Glycosyl transferase, family 2
TFU_RS08530	COG0463	Glycosyl transferase, family 2
TFU_RS08540	COG2814	Major facilitator Superfamily
TFU_RS08570	COG0583	DNA-binding transcription factor activity
TFU_RS08575	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
TFU_RS08580	COG1215	transferase activity, transferring glycosyl groups
TFU_RS08590	COG0006	proline dipeptidase activity
TFU_RS08605	COG2124	cytochrome p450
TFU_RS08620	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
TFU_RS08625	COG2264	protein methyltransferase activity
TFU_RS08635	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
TFU_RS08685	COG0815	Transfers the fatty acyl group on membrane lipoproteins
TFU_RS08690	COG3842	ATPase activity
TFU_RS08695	COG0438	transferase activity, transferring glycosyl groups
TFU_RS08700	COG4581	dead DEAH box helicase
TFU_RS08715	COG0805	protein transport
TFU_RS08720	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
TFU_RS08745	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
TFU_RS08755	COG1960	acyl-CoA dehydrogenase activity
TFU_RS08790	COG1028	Short-chain dehydrogenase reductase Sdr
TFU_RS08795	COG2186	Transcriptional regulator
TFU_RS08800	COG4948	Mandelate Racemase Muconate Lactonizing
TFU_RS08810	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
TFU_RS08815	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
TFU_RS08820	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
TFU_RS08840	COG0477	Major facilitator Superfamily
TFU_RS08850	COG4122	O-methyltransferase activity
TFU_RS08900	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
TFU_RS08905	COG1222	aaa ATPase
TFU_RS08935	COG1994	Peptidase M50
TFU_RS08935	COG0517	IMP dehydrogenase activity
TFU_RS08945	COG2197	response regulator
TFU_RS08970	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TFU_RS08980	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
TFU_RS08985	COG0646	methionine synthase
TFU_RS08985	COG1410	methionine synthase
TFU_RS09015	COG0215	cysteine-tRNA ligase activity
TFU_RS09030	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
TFU_RS09045	COG0406	alpha-ribazole phosphatase activity
TFU_RS09050	COG1968	undecaprenyl-diphosphatase activity
TFU_RS09055	COG0667	Aldo Keto reductase
TFU_RS09065	COG1028	Short-chain dehydrogenase reductase Sdr
TFU_RS09070	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
TFU_RS09075	COG1028	Short-chain dehydrogenase reductase Sdr
TFU_RS09085	COG2197	response regulator
TFU_RS09090	COG4585	Histidine kinase
TFU_RS09095	COG0577	efflux transmembrane transporter activity
TFU_RS09095	COG1136	(ABC) transporter
TFU_RS09100	COG0577	efflux transmembrane transporter activity
TFU_RS09100	COG1136	(ABC) transporter
TFU_RS09140	COG1505	serine-type exopeptidase activity
TFU_RS09160	COG2375	cellular response to nickel ion
TFU_RS09170	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
TFU_RS09200	COG1535	isochorismatase
TFU_RS09200	COG3433	isochorismatase activity
TFU_RS09215	COG1021	2,3-dihydroxybenzoate-AMP ligase
TFU_RS09220	COG1169	isochorismate synthase
TFU_RS09225	COG1028	Short-chain dehydrogenase reductase Sdr
TFU_RS09235	COG0701	Predicted permease
TFU_RS09240	COG2130	NADP-dependent
TFU_RS09250	COG1024	Enoyl-CoA hydratase
TFU_RS09260	COG0488	(ABC) transporter
TFU_RS09310	COG0175	sulfate reduction
TFU_RS09330	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
TFU_RS09335	COG0688	phosphatidylethanolamine metabolic process
TFU_RS09345	COG3253	May function as heme-dependent peroxidase
TFU_RS09360	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
TFU_RS09380	COG0183	Belongs to the thiolase family
TFU_RS09410	COG2409	Drug exporters of the RND superfamily
TFU_RS09435	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
TFU_RS09450	COG4214	carbohydrate transport
TFU_RS09460	COG4213	ABC transporter substrate-binding protein
TFU_RS09465	COG1940	carbohydrate kinase activity
TFU_RS09475	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
TFU_RS09480	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
TFU_RS09485	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
TFU_RS09490	COG0569	domain protein
TFU_RS09500	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
TFU_RS09525	COG0756	dUTP diphosphatase activity
TFU_RS09530	COG0525	valine-tRNA ligase activity
TFU_RS09550	COG2205	protein histidine kinase activity
TFU_RS09555	COG0745	RESPONSE REGULATOR receiver
TFU_RS09570	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
TFU_RS09620	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
TFU_RS09625	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
TFU_RS09640	COG5297	Belongs to the glycosyl hydrolase family 6
TFU_RS09640	COG4733	cellulase activity
TFU_RS09650	COG0009	L-threonylcarbamoyladenylate synthase
TFU_RS09675	COG0432	Pfam Uncharacterised protein family UPF0047
TFU_RS09685	COG1984	allophanate hydrolase subunit 2
TFU_RS09690	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
TFU_RS09695	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
TFU_RS09715	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
TFU_RS09720	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
TFU_RS09725	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
TFU_RS09735	COG2755	lipolytic protein G-D-S-L family
TFU_RS09750	COG2151	metal-sulfur cluster biosynthetic enzyme
TFU_RS09765	COG0396	ATPase activity
TFU_RS09790	COG1131	(ABC) transporter
TFU_RS09805	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
TFU_RS09835	COG0318	PFAM AMP-dependent synthetase and ligase
TFU_RS09840	COG1960	acyl-CoA dehydrogenase activity
TFU_RS09845	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
TFU_RS09850	COG0109	protoheme IX farnesyltransferase activity
TFU_RS09860	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
TFU_RS09865	COG0166	Belongs to the GPI family
TFU_RS09880	COG0363	glucosamine-6-phosphate deaminase activity
TFU_RS09885	COG3401	FG-GAP repeat protein
TFU_RS09890	COG3401	FG-GAP repeat protein
TFU_RS09900	COG0531	amino acid
TFU_RS09915	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
TFU_RS09920	COG0149	triose-phosphate isomerase activity
TFU_RS09925	COG0126	phosphoglycerate kinase activity
TFU_RS09930	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
TFU_RS09935	COG1481	regulation of sporulation
TFU_RS09945	COG1660	Displays ATPase and GTPase activities
TFU_RS09950	COG0322	excinuclease ABC activity
TFU_RS09965	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
TFU_RS10000	COG0497	DNA recombination
TFU_RS10005	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
TFU_RS10025	COG0647	UMP catabolic process
TFU_RS10065	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
TFU_RS10100	COG2205	protein histidine kinase activity
TFU_RS10105	COG0165	Argininosuccinate lyase
TFU_RS10110	COG0137	argininosuccinate synthase activity
TFU_RS10115	COG1438	arginine binding
TFU_RS10120	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
TFU_RS10125	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
TFU_RS10130	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
TFU_RS10135	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
TFU_RS10140	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
TFU_RS10145	COG1846	Transcriptional regulator
TFU_RS10150	COG0072	phenylalanine-tRNA ligase activity
TFU_RS10150	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TFU_RS10155	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
TFU_RS10160	COG5002	protein histidine kinase activity
TFU_RS10165	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
TFU_RS10170	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
TFU_RS10175	COG0291	Belongs to the bacterial ribosomal protein bL35 family
TFU_RS10180	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
TFU_RS10185	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
TFU_RS10195	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
TFU_RS10200	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
TFU_RS10215	COG0515	serine threonine protein kinase
TFU_RS10215	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
TFU_RS10220	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
TFU_RS10220	COG0515	serine threonine protein kinase
TFU_RS10275	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
TFU_RS10285	COG1196	nuclear chromosome segregation
TFU_RS10295	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
TFU_RS10300	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
TFU_RS10305	COG1862	Preprotein translocase
TFU_RS10310	COG2255	four-way junction helicase activity
TFU_RS10315	COG0632	four-way junction helicase activity
TFU_RS10320	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
TFU_RS10325	COG0217	transcriptional regulatory protein
TFU_RS10330	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
TFU_RS10335	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
TFU_RS10345	COG0438	transferase activity, transferring glycosyl groups
TFU_RS10355	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
TFU_RS10370	COG1253	flavin adenine dinucleotide binding
TFU_RS10380	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
TFU_RS10405	COG2018	Roadblock/LC7 domain
TFU_RS10425	COG3265	gluconokinase activity
TFU_RS10455	COG1011	Hydrolase
TFU_RS10495	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TFU_RS10510	COG0045	succinate-CoA ligase (ADP-forming) activity
TFU_RS10525	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
TFU_RS10540	COG0187	DNA topoisomerase II activity
TFU_RS10550	COG3022	response to hydroperoxide
TFU_RS10565	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
TFU_RS10585	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
TFU_RS10590	COG0464	growth
TFU_RS10595	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
TFU_RS10615	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
TFU_RS10620	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
TFU_RS10625	COG1388	LysM domain
TFU_RS10630	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
TFU_RS10650	COG0495	leucyl-tRNA aminoacylation
TFU_RS10660	COG0318	PFAM AMP-dependent synthetase and ligase
TFU_RS10670	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
TFU_RS10680	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
TFU_RS10735	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
TFU_RS10740	COG0501	Belongs to the peptidase M48B family
TFU_RS10755	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
TFU_RS10765	COG0438	transferase activity, transferring glycosyl groups
TFU_RS10770	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
TFU_RS10775	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
TFU_RS10780	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
TFU_RS10785	COG0211	Belongs to the bacterial ribosomal protein bL27 family
TFU_RS10790	COG0261	This protein binds to 23S rRNA in the presence of protein L20
TFU_RS10795	COG1530	ribonuclease E activity
TFU_RS10810	COG0772	Belongs to the SEDS family
TFU_RS10820	COG0105	UTP biosynthetic process
TFU_RS10830	COG0285	dihydrofolate synthase activity
TFU_RS10840	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
TFU_RS10845	COG0740	serine-type endopeptidase activity
TFU_RS10850	COG0740	serine-type endopeptidase activity
TFU_RS10855	COG0544	peptidyl-prolyl cis-trans isomerase activity
TFU_RS10870	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
TFU_RS10870	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
TFU_RS10875	COG1132	(ABC) transporter
TFU_RS10885	COG2239	Acts as a magnesium transporter
TFU_RS10895	COG4552	Acetyltransferase involved in intracellular survival and related
TFU_RS10900	COG0698	ribose 5-phosphate isomerase
TFU_RS10905	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
TFU_RS10935	COG0129	dihydroxy-acid dehydratase activity
TFU_RS10950	COG1505	serine-type exopeptidase activity
TFU_RS10960	COG2271	Major facilitator Superfamily
TFU_RS10985	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
TFU_RS10995	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
TFU_RS10995	COG1648	precorrin-2 dehydrogenase activity
TFU_RS11000	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
TFU_RS11055	COG4585	Histidine kinase
TFU_RS11060	COG2197	response regulator
TFU_RS11065	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
TFU_RS11070	COG3766	membrane
TFU_RS11095	COG1522	sequence-specific DNA binding
TFU_RS11120	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TFU_RS11130	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
TFU_RS11150	COG1115	amino acid carrier protein
TFU_RS11165	COG0583	DNA-binding transcription factor activity
TFU_RS11180	COG0438	transferase activity, transferring glycosyl groups
TFU_RS11210	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
TFU_RS11240	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
TFU_RS11260	COG2894	cell division
TFU_RS11290	COG2197	response regulator
TFU_RS11305	COG2885	chlorophyll binding
TFU_RS11310	COG0741	lytic transglycosylase activity
TFU_RS11310	COG0791	NLP P60 protein
TFU_RS11335	COG1192	Involved in chromosome partitioning
TFU_RS11360	COG0667	Aldo Keto reductase
TFU_RS11375	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
TFU_RS11400	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
TFU_RS11405	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
TFU_RS11410	COG0569	domain protein
TFU_RS11440	COG1960	acyl-CoA dehydrogenase activity
TFU_RS11445	COG1960	acyl-CoA dehydrogenase activity
TFU_RS11455	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
TFU_RS11460	COG1122	ATPase activity
TFU_RS11465	COG1268	BioY protein
TFU_RS11470	COG2706	6-phosphogluconolactonase activity
TFU_RS11480	COG1643	Atp-dependent helicase
TFU_RS11500	COG0477	Major facilitator Superfamily
TFU_RS11520	COG1737	Transcriptional regulator
TFU_RS11525	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
TFU_RS11530	COG2949	membrane
TFU_RS11585	COG3395	kinase activity
TFU_RS11590	COG1653	transport
TFU_RS11595	COG1175	transmembrane transport
TFU_RS11600	COG0395	ABC-type sugar transport system, permease component
TFU_RS11610	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
TFU_RS11615	COG0784	Response regulator, receiver
TFU_RS11620	COG4251	negative regulation of phosphorylation
TFU_RS11630	COG5398	heme oxygenase
TFU_RS11655	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
TFU_RS11660	COG0404	The glycine cleavage system catalyzes the degradation of glycine
TFU_RS11665	COG0509	glycine decarboxylation via glycine cleavage system
TFU_RS11670	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
TFU_RS11715	COG2815	serine threonine protein kinase
TFU_RS11715	COG0515	serine threonine protein kinase
TFU_RS11725	COG1025	Belongs to the peptidase M16 family
TFU_RS11745	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
TFU_RS11750	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
TFU_RS11785	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
TFU_RS11795	COG1335	isochorismatase
TFU_RS11845	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
TFU_RS11850	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TFU_RS11870	COG1678	Uncharacterized ACR, COG1678
TFU_RS11895	COG0183	Belongs to the thiolase family
TFU_RS11900	COG0346	lactoylglutathione lyase activity
TFU_RS11930	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
TFU_RS11955	COG0355	proton-transporting ATP synthase activity, rotational mechanism
TFU_RS11960	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
TFU_RS11965	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
TFU_RS11970	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
TFU_RS11975	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
TFU_RS11980	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
TFU_RS11985	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
TFU_RS12005	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
TFU_RS12015	COG2890	protein-(glutamine-N5) methyltransferase activity
TFU_RS12020	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
TFU_RS12025	COG0254	rRNA binding
TFU_RS12035	COG0083	homoserine kinase activity
TFU_RS12040	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
TFU_RS12045	COG0460	homoserine dehydrogenase
TFU_RS12050	COG0019	diaminopimelate decarboxylase activity
TFU_RS12055	COG0018	arginyl-trna synthetase
TFU_RS12065	COG2272	Belongs to the type-B carboxylesterase lipase family
TFU_RS12095	COG0242	peptide deformylase activity
TFU_RS12180	COG1061	Type III restriction enzyme res subunit
TFU_RS12185	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
TFU_RS12190	COG1053	succinate dehydrogenase
TFU_RS12200	COG0583	DNA-binding transcription factor activity
TFU_RS12210	COG1217	gtp-binding protein TYPA
TFU_RS12215	COG0494	nUDIX hydrolase
TFU_RS12235	COG0277	FAD linked oxidase domain protein
TFU_RS12240	COG1028	Short-chain dehydrogenase reductase Sdr
TFU_RS12250	COG2226	methyltransferase
TFU_RS12255	COG0500	methyltransferase
TFU_RS12265	COG4981	capsule polysaccharide biosynthetic process
TFU_RS12310	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
TFU_RS12315	COG2177	Part of the ABC transporter FtsEX involved in
TFU_RS12320	COG2884	Cell division ATP-binding protein ftsE
TFU_RS12325	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
TFU_RS12335	COG2902	Dehydrogenase
TFU_RS12350	COG1011	Hydrolase
TFU_RS12355	COG1960	acyl-CoA dehydrogenase activity
TFU_RS12360	COG1472	Belongs to the glycosyl hydrolase 3 family
TFU_RS12365	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
TFU_RS12380	COG0653	protein targeting
TFU_RS12385	COG2197	response regulator
TFU_RS12390	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
TFU_RS12395	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
TFU_RS12400	COG5401	PFAM Sporulation and spore germination
TFU_RS12405	COG5002	protein histidine kinase activity
TFU_RS12405	COG5000	phosphorelay sensor kinase activity
TFU_RS12410	COG0745	RESPONSE REGULATOR receiver
TFU_RS12430	COG0714	Associated with various cellular activities
TFU_RS12455	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
TFU_RS12510	COG0391	Required for morphogenesis under gluconeogenic growth conditions
TFU_RS12515	COG0778	Nitroreductase
TFU_RS12515	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
TFU_RS12520	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
TFU_RS12525	COG2226	methyltransferase
TFU_RS12535	COG0438	transferase activity, transferring glycosyl groups
TFU_RS12555	COG1316	TRANSCRIPTIONal
TFU_RS12575	COG0778	Nitroreductase
TFU_RS12590	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
TFU_RS12620	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
TFU_RS12635	COG1316	TRANSCRIPTIONal
TFU_RS12645	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
TFU_RS12650	COG1832	CoA-binding protein
TFU_RS12655	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
TFU_RS12670	COG0745	RESPONSE REGULATOR receiver
TFU_RS12675	COG2205	protein histidine kinase activity
TFU_RS12685	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
TFU_RS12690	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
TFU_RS12690	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
TFU_RS12695	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
TFU_RS12700	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
TFU_RS12710	COG4770	biotin carboxylase activity
TFU_RS12735	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
TFU_RS12740	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
TFU_RS12740	COG1473	amidohydrolase
TFU_RS12745	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
TFU_RS12755	COG1316	TRANSCRIPTIONal
TFU_RS12775	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
TFU_RS12780	COG0138	bifunctional purine biosynthesis protein purh
TFU_RS12805	COG0045	succinate-CoA ligase (ADP-forming) activity
TFU_RS12845	COG2197	response regulator
TFU_RS12850	COG4585	Histidine kinase
TFU_RS12880	COG0519	Catalyzes the synthesis of GMP from XMP
TFU_RS12880	COG0518	GMP synthase (glutamine-hydrolyzing) activity
TFU_RS12885	COG1012	belongs to the aldehyde dehydrogenase family
TFU_RS12890	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
TFU_RS12895	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
TFU_RS12900	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
TFU_RS12910	COG0516	GMP reductase activity
TFU_RS12920	COG1595	DNA-templated transcription, initiation
TFU_RS12925	COG0459	protein refolding
TFU_RS12930	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
TFU_RS12945	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
TFU_RS12950	COG1247	-acetyltransferase
TFU_RS12955	COG1214	PFAM Peptidase M22, glycoprotease
TFU_RS12955	COG0456	acetyltransferase
TFU_RS12960	COG0802	atpase or kinase
TFU_RS12965	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
TFU_RS12985	COG1072	(Pantothenic acid kinase))
TFU_RS12990	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
TFU_RS12995	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
TFU_RS13000	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
TFU_RS13005	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
TFU_RS13015	COG0101	tRNA pseudouridine synthase activity
TFU_RS13020	COG0203	ribosomal protein L17
TFU_RS13025	COG0202	RNA polymerase activity
TFU_RS13030	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
TFU_RS13035	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
TFU_RS13040	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
TFU_RS13050	COG0024	Methionine aminopeptidase
TFU_RS13055	COG0563	adenylate kinase activity
TFU_RS13065	COG0200	Binds to the 23S rRNA
TFU_RS13070	COG1841	ribosomal large subunit assembly
TFU_RS13075	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
TFU_RS13080	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
TFU_RS13085	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
TFU_RS13090	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
TFU_RS13095	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
TFU_RS13100	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
TFU_RS13105	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
TFU_RS13110	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
TFU_RS13115	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
TFU_RS13120	COG0255	Belongs to the universal ribosomal protein uL29 family
TFU_RS13125	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
TFU_RS13130	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
TFU_RS13135	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
TFU_RS13140	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
TFU_RS13145	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
TFU_RS13150	COG0089	rRNA binding
TFU_RS13155	COG0088	Forms part of the polypeptide exit tunnel
TFU_RS13160	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
TFU_RS13165	COG0051	transcription antitermination factor activity, RNA binding
TFU_RS13170	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
TFU_RS13175	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
TFU_RS13180	COG0049	tRNA binding
TFU_RS13185	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
TFU_RS13195	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
TFU_RS13200	COG0085	RNA polymerase activity
TFU_RS13205	COG0222	ribosome binding
TFU_RS13210	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
TFU_RS13215	COG0081	regulation of translation
TFU_RS13220	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
TFU_RS13230	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
TFU_RS13240	COG0436	Aminotransferase
TFU_RS13245	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
TFU_RS13250	COG2119	membrane
TFU_RS13255	COG0812	UDP-N-acetylmuramate dehydrogenase activity
TFU_RS13265	COG2030	dehydratase
TFU_RS13270	COG0267	Belongs to the bacterial ribosomal protein bL33 family
TFU_RS13285	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
TFU_RS13310	COG1666	GTP binding
TFU_RS13315	COG0501	Belongs to the peptidase M48B family
TFU_RS13320	COG0674	pyruvate-flavodoxin oxidoreductase activity
TFU_RS13320	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
TFU_RS13325	COG1013	pyruvate-flavodoxin oxidoreductase activity
TFU_RS13330	COG0702	epimerase
TFU_RS13340	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
TFU_RS13355	COG0142	geranyltranstransferase activity
TFU_RS13360	COG1007	ATP synthesis coupled electron transport
TFU_RS13375	COG0713	ATP synthesis coupled electron transport
TFU_RS13385	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TFU_RS13390	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
TFU_RS13395	COG1034	ATP synthesis coupled electron transport
TFU_RS13400	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
TFU_RS13410	COG0649	NAD binding
TFU_RS13415	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TFU_RS13420	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TFU_RS13435	COG2226	methyltransferase
TFU_RS13455	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
TFU_RS13460	COG1333	cytochrome c biogenesis protein
TFU_RS13465	COG0785	Cytochrome C biogenesis protein
TFU_RS13470	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
TFU_RS13485	COG0123	including yeast histone deacetylase and acetoin utilization protein
TFU_RS13495	COG1082	Xylose isomerase domain protein TIM barrel
TFU_RS13500	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
TFU_RS13515	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
TFU_RS13535	COG2897	thiosulfate sulfurtransferase activity
TFU_RS13560	COG0406	alpha-ribazole phosphatase activity
TFU_RS13565	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
TFU_RS13570	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
TFU_RS13585	COG0113	porphobilinogen synthase activity
TFU_RS13595	COG0181	hydroxymethylbilane synthase activity
TFU_RS13600	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
TFU_RS13605	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
TFU_RS13620	COG0745	RESPONSE REGULATOR receiver
TFU_RS13630	COG0456	acetyltransferase
TFU_RS13650	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
TFU_RS13655	COG0306	phosphate transporter
TFU_RS13660	COG1392	Phosphate transport regulator
TFU_RS13675	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
TFU_RS13695	COG3339	Conserved Protein
TFU_RS13700	COG0860	N-Acetylmuramoyl-L-alanine amidase
TFU_RS13720	COG1739	Uncharacterized protein family UPF0029
TFU_RS13730	COG0386	Belongs to the glutathione peroxidase family
TFU_RS13760	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
TFU_RS13775	COG1486	melibiose metabolic process
TFU_RS13785	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
TFU_RS13830	COG1774	PSP1 C-terminal conserved region
TFU_RS13840	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
TFU_RS13845	COG1754	DNA topoisomerase type I activity
TFU_RS13845	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
TFU_RS13855	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
TFU_RS13875	COG1609	Transcriptional regulator
TFU_RS13910	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
TFU_RS13915	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
TFU_RS13915	COG2508	Transcriptional regulator
TFU_RS13960	COG2205	protein histidine kinase activity
TFU_RS13965	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TFU_RS13970	COG2197	response regulator
TFU_RS13980	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
TFU_RS13980	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
TFU_RS13980	COG1703	isobutyryl-CoA mutase activity
TFU_RS13995	COG1063	alcohol dehydrogenase
TFU_RS14000	COG2267	carboxylic ester hydrolase activity
TFU_RS14010	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
TFU_RS14015	COG4260	virion core protein, lumpy skin disease virus
TFU_RS14030	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
TFU_RS14035	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
TFU_RS14065	COG0693	protein deglycase activity
TFU_RS14075	COG1309	transcriptional regulator
TFU_RS14080	COG2814	Major facilitator Superfamily
TFU_RS14095	COG2255	four-way junction helicase activity
TFU_RS14130	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
TFU_RS14140	COG3629	intracellular signal transduction
TFU_RS14140	COG3903	Transcriptional regulator
TFU_RS14150	COG0515	serine threonine protein kinase
TFU_RS14155	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
TFU_RS14210	COG1983	PspC domain protein
TFU_RS14215	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TFU_RS14220	COG3275	phosphorelay sensor kinase activity
TFU_RS14225	COG3279	Response regulator of the LytR AlgR family
TFU_RS14245	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
TFU_RS14300	COG3485	protocatechuate 3,4-dioxygenase
TFU_RS14305	COG0354	folic acid binding
TFU_RS14340	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
TFU_RS14350	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
TFU_RS14355	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
TFU_RS14360	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
TFU_RS14365	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
TFU_RS14400	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
TFU_RS14410	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
TFU_RS14415	COG0302	gtp cyclohydrolase
TFU_RS14430	COG0037	tRNA processing
TFU_RS14455	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
TFU_RS14460	COG2027	D-alanyl-D-alanine carboxypeptidase
TFU_RS14475	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
TFU_RS14480	COG1329	Transcriptional regulator
TFU_RS14490	COG5002	protein histidine kinase activity
TFU_RS14500	COG0588	phosphoglycerate mutase activity
TFU_RS14510	COG0438	transferase activity, transferring glycosyl groups
TFU_RS14555	COG1490	D-aminoacyl-tRNA deacylase activity
TFU_RS14585	COG2113	Glycine betaine
TFU_RS14595	COG0517	IMP dehydrogenase activity
TFU_RS14595	COG4175	Glycine betaine
TFU_RS14605	COG0717	Belongs to the dCTP deaminase family
TFU_RS14625	COG2188	Transcriptional regulator
TFU_RS14635	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
TFU_RS14655	COG0582	viral genome integration into host DNA
TFU_RS14690	COG0352	thiamine-phosphate diphosphorylase activity
TFU_RS14690	COG0351	phosphomethylpyrimidine kinase
TFU_RS14690	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
TFU_RS14710	COG1316	TRANSCRIPTIONal
TFU_RS14730	COG2205	protein histidine kinase activity
TFU_RS14780	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
TFU_RS14785	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
TFU_RS14805	COG2124	cytochrome p450
TFU_RS14810	COG2124	cytochrome p450
TFU_RS14910	COG0435	Glutathione S-transferase
TFU_RS14920	COG2409	Drug exporters of the RND superfamily
TFU_RS14940	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
TFU_RS14940	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
TFU_RS14945	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
TFU_RS14950	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
TFU_RS14970	COG1324	tolerance protein
TFU_RS14975	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
TFU_RS14995	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
TFU_RS15000	COG0151	Belongs to the GarS family
TFU_RS15005	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
TFU_RS15010	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
TFU_RS15015	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
TFU_RS15025	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
TFU_RS15045	COG1595	DNA-templated transcription, initiation
TFU_RS15085	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
TFU_RS15090	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
TFU_RS15100	COG0589	response to stress
TFU_RS15150	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
TFU_RS15180	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
TFU_RS15185	COG0508	dehydrogenase complex catalyzes the overall conversion of
TFU_RS15185	COG0022	dehydrogenase e1 component
TFU_RS15190	COG0508	dehydrogenase complex catalyzes the overall conversion of
TFU_RS15200	COG0077	Prephenate dehydratase
TFU_RS15205	COG0463	Glycosyl transferase, family 2
TFU_RS15220	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
TFU_RS15240	COG1716	ATPase activity
TFU_RS15245	COG3266	domain, Protein
TFU_RS15245	COG0631	protein serine/threonine phosphatase activity
TFU_RS15255	COG0768	penicillin binding
TFU_RS15260	COG0515	serine threonine protein kinase
TFU_RS15265	COG0515	serine threonine protein kinase
TFU_RS15275	COG0705	Rhomboid family
TFU_RS15340	COG2837	iron assimilation
TFU_RS15365	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
TFU_RS15375	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TFU_RS15400	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
TFU_RS15410	COG0359	binds to the 23S rRNA
TFU_RS15415	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
TFU_RS15420	COG0629	single-stranded DNA binding
TFU_RS15425	COG0360	Binds together with S18 to 16S ribosomal RNA
TFU_RS15435	COG4499	WXG100 protein secretion system (Wss), protein YukC
TFU_RS15435	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
TFU_RS15475	COG2815	serine threonine protein kinase
TFU_RS15475	COG0515	serine threonine protein kinase
TFU_RS15480	COG1595	DNA-templated transcription, initiation
TFU_RS15490	COG0492	ferredoxin-NADP+ reductase activity
TFU_RS15495	COG3118	belongs to the thioredoxin family
TFU_RS15505	COG1192	Involved in chromosome partitioning
TFU_RS15510	COG0357	Ribosomal RNA small subunit methyltransferase G
TFU_RS15520	COG0706	membrane insertase activity
TFU_RS15525	COG0594	ribonuclease P activity
TFU_RS15580	COG4717	serine-type aminopeptidase activity