locus-tag	class	description
TBIS_RS00010	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
TBIS_RS00015	COG0592	DNA-directed DNA polymerase activity
TBIS_RS00020	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
TBIS_RS00025	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
TBIS_RS00030	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
TBIS_RS00035	COG0187	DNA topoisomerase II activity
TBIS_RS00040	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
TBIS_RS00055	COG1742	UPF0060 membrane protein
TBIS_RS00080	COG2608	mercury ion transmembrane transporter activity
TBIS_RS00085	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
TBIS_RS00100	COG4604	ABC transporter, ATP-binding protein
TBIS_RS00105	COG4605	iron ion homeostasis
TBIS_RS00110	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TBIS_RS00115	COG4607	ABC-type enterochelin transport system periplasmic component
TBIS_RS00140	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
TBIS_RS00195	COG1215	transferase activity, transferring glycosyl groups
TBIS_RS00220	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
TBIS_RS00230	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
TBIS_RS00235	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
TBIS_RS00250	COG1316	TRANSCRIPTIONal
TBIS_RS00275	COG1716	ATPase activity
TBIS_RS00290	COG0768	penicillin binding
TBIS_RS00295	COG0515	serine threonine protein kinase
TBIS_RS00300	COG0515	serine threonine protein kinase
TBIS_RS00345	COG0840	transmembrane signaling receptor activity
TBIS_RS00365	COG1175	transmembrane transport
TBIS_RS00370	COG1653	transport
TBIS_RS00385	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
TBIS_RS00390	COG1278	Cold shock
TBIS_RS00395	COG0561	phosphatase activity
TBIS_RS00475	COG2186	Transcriptional regulator
TBIS_RS00495	COG1309	transcriptional regulator
TBIS_RS00510	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
TBIS_RS00540	COG3391	amine dehydrogenase activity
TBIS_RS00600	COG1595	DNA-templated transcription, initiation
TBIS_RS00610	COG1846	Transcriptional regulator
TBIS_RS00655	COG2814	Major facilitator Superfamily
TBIS_RS00665	COG3226	Transcriptional regulator
TBIS_RS00675	COG1322	Protein conserved in bacteria
TBIS_RS00685	COG1115	amino acid carrier protein
TBIS_RS00700	COG2207	Transcriptional regulator
TBIS_RS00700	COG3708	Transcriptional regulator
TBIS_RS00715	COG0633	Ferredoxin
TBIS_RS00715	COG0543	2 iron, 2 sulfur cluster binding
TBIS_RS00720	COG1151	hydroxylamine reductase activity
TBIS_RS00735	COG1522	sequence-specific DNA binding
TBIS_RS00760	COG1940	carbohydrate kinase activity
TBIS_RS00770	COG1070	Carbohydrate kinase
TBIS_RS00790	COG2018	Roadblock/LC7 domain
TBIS_RS00845	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
TBIS_RS00855	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
TBIS_RS00860	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
TBIS_RS00865	COG0151	Belongs to the GarS family
TBIS_RS00875	COG1309	transcriptional regulator
TBIS_RS00890	COG0584	glycerophosphoryl diester phosphodiesterase
TBIS_RS00895	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
TBIS_RS00920	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
TBIS_RS00930	COG1432	Conserved Protein
TBIS_RS00940	COG5002	protein histidine kinase activity
TBIS_RS00940	COG0784	Response regulator, receiver
TBIS_RS00945	COG2208	phosphoserine phosphatase activity
TBIS_RS00945	COG2770	Histidine kinase
TBIS_RS00950	COG2226	methyltransferase
TBIS_RS00985	COG1408	metallophosphoesterase
TBIS_RS00995	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
TBIS_RS01005	COG0003	Pfam Anion-transporting ATPase
TBIS_RS01025	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TBIS_RS01045	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TBIS_RS01055	COG0596	Alpha beta hydrolase
TBIS_RS01065	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TBIS_RS01110	COG1205	dead DEAH box helicase
TBIS_RS01110	COG1111	helicase
TBIS_RS01115	COG1366	Belongs to the anti-sigma-factor antagonist family
TBIS_RS01125	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
TBIS_RS01135	COG0560	Phosphoserine phosphatase
TBIS_RS01135	COG3830	Belongs to the UPF0237 family
TBIS_RS01150	COG4585	Histidine kinase
TBIS_RS01155	COG2197	response regulator
TBIS_RS01160	COG1119	ATPase activity
TBIS_RS01195	COG0753	catalase activity
TBIS_RS01210	COG1309	transcriptional regulator
TBIS_RS01230	COG0542	response to heat
TBIS_RS01235	COG0789	Transcriptional regulator
TBIS_RS01240	COG0484	heat shock protein binding
TBIS_RS01245	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
TBIS_RS01250	COG0443	Heat shock 70 kDa protein
TBIS_RS01260	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
TBIS_RS01265	COG0123	including yeast histone deacetylase and acetoin utilization protein
TBIS_RS01300	COG1595	DNA-templated transcription, initiation
TBIS_RS01315	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
TBIS_RS01320	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
TBIS_RS01325	COG0181	hydroxymethylbilane synthase activity
TBIS_RS01335	COG0113	porphobilinogen synthase activity
TBIS_RS01345	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
TBIS_RS01355	COG0406	alpha-ribazole phosphatase activity
TBIS_RS01360	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
TBIS_RS01365	COG0785	Cytochrome C biogenesis protein
TBIS_RS01375	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
TBIS_RS01405	COG2226	methyltransferase
TBIS_RS01420	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TBIS_RS01425	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TBIS_RS01430	COG0649	NAD binding
TBIS_RS01445	COG1034	ATP synthesis coupled electron transport
TBIS_RS01450	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
TBIS_RS01455	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TBIS_RS01480	COG1007	ATP synthesis coupled electron transport
TBIS_RS01485	COG0142	geranyltranstransferase activity
TBIS_RS01500	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
TBIS_RS01535	COG0697	spore germination
TBIS_RS01545	COG0444	Belongs to the ABC transporter superfamily
TBIS_RS01550	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TBIS_RS01560	COG0747	negative chemotaxis
TBIS_RS01575	COG1013	pyruvate-flavodoxin oxidoreductase activity
TBIS_RS01580	COG0674	pyruvate-flavodoxin oxidoreductase activity
TBIS_RS01580	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
TBIS_RS01585	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TBIS_RS01590	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TBIS_RS01595	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TBIS_RS01600	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
TBIS_RS01610	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TBIS_RS01620	COG0713	ATP synthesis coupled electron transport
TBIS_RS01635	COG1007	ATP synthesis coupled electron transport
TBIS_RS01640	COG0501	Belongs to the peptidase M48B family
TBIS_RS01650	COG0765	amino acid transport
TBIS_RS01655	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
TBIS_RS01670	COG1666	GTP binding
TBIS_RS01720	COG0494	nUDIX hydrolase
TBIS_RS01735	COG1247	-acetyltransferase
TBIS_RS01740	COG0640	Transcriptional regulator
TBIS_RS01770	COG1366	Belongs to the anti-sigma-factor antagonist family
TBIS_RS01795	COG0267	Belongs to the bacterial ribosomal protein bL33 family
TBIS_RS01800	COG2030	dehydratase
TBIS_RS01810	COG0812	UDP-N-acetylmuramate dehydrogenase activity
TBIS_RS01815	COG2119	membrane
TBIS_RS01820	COG1672	PFAM Archaeal ATPase
TBIS_RS01820	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
TBIS_RS01830	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
TBIS_RS01835	COG1012	belongs to the aldehyde dehydrogenase family
TBIS_RS01840	COG1012	belongs to the aldehyde dehydrogenase family
TBIS_RS01855	COG0321	lipoyl(octanoyl) transferase activity
TBIS_RS01865	COG0803	Belongs to the bacterial solute-binding protein 9 family
TBIS_RS01870	COG1121	(ABC) transporter
TBIS_RS01880	COG1108	ABC-type Mn2 Zn2 transport systems permease components
TBIS_RS01910	COG0640	Transcriptional regulator
TBIS_RS01915	COG1902	pentaerythritol trinitrate reductase activity
TBIS_RS01920	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
TBIS_RS01940	COG3903	Transcriptional regulator
TBIS_RS01940	COG3629	intracellular signal transduction
TBIS_RS01945	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
TBIS_RS01950	COG3509	depolymerase
TBIS_RS01955	COG2856	Zn peptidase
TBIS_RS01975	COG0517	IMP dehydrogenase activity
TBIS_RS01975	COG0617	tRNA 3'-terminal CCA addition
TBIS_RS01975	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
TBIS_RS01980	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
TBIS_RS01985	COG1993	acr, cog1993
TBIS_RS01990	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
TBIS_RS02030	COG1309	transcriptional regulator
TBIS_RS02040	COG0559	Belongs to the binding-protein-dependent transport system permease family
TBIS_RS02060	COG4326	sporulation control protein
TBIS_RS02065	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
TBIS_RS02070	COG1309	transcriptional regulator
TBIS_RS02170	COG0183	Belongs to the thiolase family
TBIS_RS02175	COG0640	Transcriptional regulator
TBIS_RS02180	COG0402	S-adenosylhomocysteine deaminase activity
TBIS_RS02245	COG0717	Belongs to the dCTP deaminase family
TBIS_RS02260	COG0456	acetyltransferase
TBIS_RS02265	COG0737	Belongs to the 5'-nucleotidase family
TBIS_RS02270	COG0745	RESPONSE REGULATOR receiver
TBIS_RS02305	COG2897	thiosulfate sulfurtransferase activity
TBIS_RS02345	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
TBIS_RS02350	COG3442	glutamine amidotransferase
TBIS_RS02360	COG4044	May play a role in the intracellular transport of hydrophobic ligands
TBIS_RS02365	COG0735	belongs to the Fur family
TBIS_RS02370	COG1366	Belongs to the anti-sigma-factor antagonist family
TBIS_RS02375	COG1366	Belongs to the anti-sigma-factor antagonist family
TBIS_RS02380	COG2172	sigma factor antagonist activity
TBIS_RS02390	COG2205	protein histidine kinase activity
TBIS_RS02390	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
TBIS_RS02400	COG0354	folic acid binding
TBIS_RS02405	COG1490	D-aminoacyl-tRNA deacylase activity
TBIS_RS02415	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
TBIS_RS02425	COG0598	Magnesium transport protein CorA
TBIS_RS02445	COG0501	Belongs to the peptidase M48B family
TBIS_RS02470	COG0438	transferase activity, transferring glycosyl groups
TBIS_RS02480	COG0588	phosphoglycerate mutase activity
TBIS_RS02490	COG5002	protein histidine kinase activity
TBIS_RS02505	COG1329	Transcriptional regulator
TBIS_RS02510	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
TBIS_RS02530	COG0215	cysteine-tRNA ligase activity
TBIS_RS02550	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
TBIS_RS02565	COG0310	cobalt ion transport
TBIS_RS02575	COG1122	ATPase activity
TBIS_RS02585	COG1024	Enoyl-CoA hydratase
TBIS_RS02595	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
TBIS_RS02605	COG0259	pyridoxamine-phosphate oxidase activity
TBIS_RS02610	COG1573	uracil-dna glycosylase
TBIS_RS02625	COG1960	acyl-CoA dehydrogenase activity
TBIS_RS02665	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
TBIS_RS02670	COG0436	Aminotransferase
TBIS_RS02690	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
TBIS_RS02695	COG0081	regulation of translation
TBIS_RS02710	COG0222	ribosome binding
TBIS_RS02715	COG0085	RNA polymerase activity
TBIS_RS02720	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
TBIS_RS02725	COG0635	Involved in the biosynthesis of porphyrin-containing compound
TBIS_RS02730	COG2124	cytochrome p450
TBIS_RS02735	COG2124	cytochrome p450
TBIS_RS02740	COG1309	transcriptional regulator
TBIS_RS02780	COG1473	amidohydrolase
TBIS_RS02785	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
TBIS_RS02790	COG0049	tRNA binding
TBIS_RS02795	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
TBIS_RS02805	COG0051	transcription antitermination factor activity, RNA binding
TBIS_RS02810	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
TBIS_RS02815	COG0088	Forms part of the polypeptide exit tunnel
TBIS_RS02820	COG0089	rRNA binding
TBIS_RS02825	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
TBIS_RS02830	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
TBIS_RS02835	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
TBIS_RS02840	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
TBIS_RS02845	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
TBIS_RS02850	COG0255	Belongs to the universal ribosomal protein uL29 family
TBIS_RS02855	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
TBIS_RS02860	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
TBIS_RS02865	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
TBIS_RS02870	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
TBIS_RS02875	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
TBIS_RS02880	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
TBIS_RS02885	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
TBIS_RS02890	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
TBIS_RS02895	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
TBIS_RS02900	COG1841	ribosomal large subunit assembly
TBIS_RS02905	COG0200	Binds to the 23S rRNA
TBIS_RS02915	COG0563	adenylate kinase activity
TBIS_RS02940	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
TBIS_RS02945	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
TBIS_RS02950	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
TBIS_RS02955	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
TBIS_RS02960	COG0202	RNA polymerase activity
TBIS_RS02965	COG0203	ribosomal protein L17
TBIS_RS02970	COG0101	tRNA pseudouridine synthase activity
TBIS_RS02990	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
TBIS_RS02995	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
TBIS_RS03000	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
TBIS_RS03010	COG1131	(ABC) transporter
TBIS_RS03025	COG1072	(Pantothenic acid kinase))
TBIS_RS03030	COG0736	holo-[acyl-carrier-protein] synthase activity
TBIS_RS03040	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
TBIS_RS03050	COG0802	atpase or kinase
TBIS_RS03070	COG1214	PFAM Peptidase M22, glycoprotease
TBIS_RS03070	COG0456	acetyltransferase
TBIS_RS03075	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
TBIS_RS03090	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
TBIS_RS03095	COG0459	protein refolding
TBIS_RS03100	COG1595	DNA-templated transcription, initiation
TBIS_RS03115	COG0516	GMP reductase activity
TBIS_RS03120	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
TBIS_RS03125	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
TBIS_RS03130	COG1012	belongs to the aldehyde dehydrogenase family
TBIS_RS03140	COG0519	Catalyzes the synthesis of GMP from XMP
TBIS_RS03140	COG0518	GMP synthase (glutamine-hydrolyzing) activity
TBIS_RS03150	COG0789	Transcriptional regulator
TBIS_RS03160	COG0726	polysaccharide deacetylase
TBIS_RS03170	COG0463	Glycosyl transferase, family 2
TBIS_RS03175	COG1216	Glycosyl transferase, family 2
TBIS_RS03195	COG0438	transferase activity, transferring glycosyl groups
TBIS_RS03205	COG0457	Tetratricopeptide repeat
TBIS_RS03250	COG2197	response regulator
TBIS_RS03260	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
TBIS_RS03275	COG0045	succinate-CoA ligase (ADP-forming) activity
TBIS_RS03305	COG0138	bifunctional purine biosynthesis protein purh
TBIS_RS03310	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
TBIS_RS03320	COG0372	Belongs to the citrate synthase family
TBIS_RS03350	COG1253	flavin adenine dinucleotide binding
TBIS_RS03355	COG0180	Tryptophanyl-tRNA synthetase
TBIS_RS03365	COG1686	Belongs to the peptidase S11 family
TBIS_RS03375	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
TBIS_RS03380	COG1473	amidohydrolase
TBIS_RS03380	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
TBIS_RS03385	COG1744	ABC transporter substrate-binding protein PnrA-like
TBIS_RS03390	COG3845	ABC transporter
TBIS_RS03395	COG4603	Belongs to the binding-protein-dependent transport system permease family
TBIS_RS03405	COG1079	Belongs to the binding-protein-dependent transport system permease family
TBIS_RS03425	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
TBIS_RS03435	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
TBIS_RS03460	COG4770	biotin carboxylase activity
TBIS_RS03470	COG1674	ftsk spoiiie
TBIS_RS03495	COG1432	Conserved Protein
TBIS_RS03505	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
TBIS_RS03510	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
TBIS_RS03525	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
TBIS_RS03535	COG2193	ferroxidase activity
TBIS_RS03540	COG0745	RESPONSE REGULATOR receiver
TBIS_RS03545	COG5002	protein histidine kinase activity
TBIS_RS03570	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
TBIS_RS03585	COG1285	pathogenesis
TBIS_RS03590	COG1316	TRANSCRIPTIONal
TBIS_RS03600	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
TBIS_RS03615	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
TBIS_RS03620	COG0371	Dehydrogenase
TBIS_RS03650	COG1316	TRANSCRIPTIONal
TBIS_RS03690	COG1271	oxidase subunit
TBIS_RS03695	COG1294	oxidase, subunit
TBIS_RS03700	COG4988	ABC transporter
TBIS_RS03705	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
TBIS_RS03720	COG2226	methyltransferase
TBIS_RS03740	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
TBIS_RS03750	COG0778	Nitroreductase
TBIS_RS03750	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
TBIS_RS03755	COG0391	Required for morphogenesis under gluconeogenic growth conditions
TBIS_RS03790	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
TBIS_RS03815	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
TBIS_RS03820	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
TBIS_RS03850	COG0745	RESPONSE REGULATOR receiver
TBIS_RS03855	COG5002	protein histidine kinase activity
TBIS_RS03860	COG0823	Involved in the tonB-independent uptake of proteins
TBIS_RS03870	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
TBIS_RS03875	COG2197	response regulator
TBIS_RS03885	COG0653	protein targeting
TBIS_RS03900	COG3509	depolymerase
TBIS_RS03905	COG2188	Transcriptional regulator
TBIS_RS03910	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
TBIS_RS03915	COG1472	Belongs to the glycosyl hydrolase 3 family
TBIS_RS03920	COG1011	Hydrolase
TBIS_RS03935	COG0546	phosphoglycolate phosphatase activity
TBIS_RS03940	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TBIS_RS03945	COG2902	Dehydrogenase
TBIS_RS03955	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
TBIS_RS03960	COG2884	Cell division ATP-binding protein ftsE
TBIS_RS03965	COG2177	Part of the ABC transporter FtsEX involved in
TBIS_RS03970	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
TBIS_RS03985	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TBIS_RS04000	COG1960	acyl-CoA dehydrogenase activity
TBIS_RS04015	COG4981	capsule polysaccharide biosynthetic process
TBIS_RS04025	COG0500	methyltransferase
TBIS_RS04050	COG0277	FAD linked oxidase domain protein
TBIS_RS04055	COG0300	oxidoreductase activity
TBIS_RS04095	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
TBIS_RS04100	COG0686	Belongs to the AlaDH PNT family
TBIS_RS04110	COG0789	Transcriptional regulator
TBIS_RS04115	COG0405	Gamma-glutamyltransferase
TBIS_RS04135	COG2814	Major facilitator Superfamily
TBIS_RS04155	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
TBIS_RS04200	COG1653	transport
TBIS_RS04205	COG2273	Hydrolase Family 16
TBIS_RS04235	COG2208	phosphoserine phosphatase activity
TBIS_RS04235	COG2770	Histidine kinase
TBIS_RS04245	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
TBIS_RS04270	COG2271	Major facilitator Superfamily
TBIS_RS04285	COG0515	serine threonine protein kinase
TBIS_RS04285	COG2815	serine threonine protein kinase
TBIS_RS04320	COG0395	ABC-type sugar transport system, permease component
TBIS_RS04325	COG1175	transmembrane transport
TBIS_RS04330	COG1653	transport
TBIS_RS04335	COG1653	transport
TBIS_RS04345	COG1136	(ABC) transporter
TBIS_RS04355	COG0366	Alpha amylase catalytic
TBIS_RS04375	COG0019	diaminopimelate decarboxylase activity
TBIS_RS04380	COG0460	homoserine dehydrogenase
TBIS_RS04395	COG1215	transferase activity, transferring glycosyl groups
TBIS_RS04405	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
TBIS_RS04410	COG0083	homoserine kinase activity
TBIS_RS04420	COG0254	rRNA binding
TBIS_RS04425	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
TBIS_RS04430	COG2890	protein-(glutamine-N5) methyltransferase activity
TBIS_RS04460	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
TBIS_RS04465	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
TBIS_RS04470	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
TBIS_RS04475	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
TBIS_RS04480	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
TBIS_RS04485	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
TBIS_RS04490	COG0355	proton-transporting ATP synthase activity, rotational mechanism
TBIS_RS04505	COG4152	abc transporter atp-binding protein
TBIS_RS04510	COG1668	transmembrane transport
TBIS_RS04520	COG2197	response regulator
TBIS_RS04540	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
TBIS_RS04555	COG0596	Alpha beta hydrolase
TBIS_RS04570	COG0183	Belongs to the thiolase family
TBIS_RS04605	COG1678	Uncharacterized ACR, COG1678
TBIS_RS04615	COG0477	Major facilitator Superfamily
TBIS_RS04645	COG1335	isochorismatase
TBIS_RS04655	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
TBIS_RS04685	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
TBIS_RS04690	COG1234	tRNA 3'-trailer cleavage
TBIS_RS04695	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
TBIS_RS04700	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
TBIS_RS04720	COG0477	Major facilitator Superfamily
TBIS_RS04730	COG1136	(ABC) transporter
TBIS_RS04730	COG0577	efflux transmembrane transporter activity
TBIS_RS04735	COG1136	(ABC) transporter
TBIS_RS04735	COG0577	efflux transmembrane transporter activity
TBIS_RS04740	COG2197	response regulator
TBIS_RS04745	COG4585	Histidine kinase
TBIS_RS04790	COG0509	glycine decarboxylation via glycine cleavage system
TBIS_RS04795	COG0404	The glycine cleavage system catalyzes the degradation of glycine
TBIS_RS04810	COG4221	oxidoreductase activity
TBIS_RS04820	COG1228	amidohydrolase
TBIS_RS04850	COG2018	Roadblock/LC7 domain
TBIS_RS04865	COG5002	protein histidine kinase activity
TBIS_RS04870	COG2018	Roadblock/LC7 domain
TBIS_RS04890	COG0228	four-way junction DNA binding
TBIS_RS04895	COG1837	Belongs to the UPF0109 family
TBIS_RS04900	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
TBIS_RS04905	COG0336	Belongs to the RNA methyltransferase TrmD family
TBIS_RS04910	COG0335	large ribosomal subunit rRNA binding
TBIS_RS04915	COG0681	Belongs to the peptidase S26 family
TBIS_RS04925	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
TBIS_RS04960	COG0792	nuclease activity
TBIS_RS04965	COG1804	L-carnitine dehydratase bile acid-inducible protein F
TBIS_RS04970	COG0052	Belongs to the universal ribosomal protein uS2 family
TBIS_RS04975	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
TBIS_RS04980	COG0528	UMP kinase activity
TBIS_RS04985	COG0233	cytoplasmic translational termination
TBIS_RS04990	COG0575	Belongs to the CDS family
TBIS_RS05000	COG0820	rRNA (adenine-C2-)-methyltransferase activity
TBIS_RS05010	COG3835	regulator
TBIS_RS05035	COG1012	belongs to the aldehyde dehydrogenase family
TBIS_RS05040	COG3842	ATPase activity
TBIS_RS05050	COG1176	ABC-type spermidine putrescine transport system, permease component I
TBIS_RS05055	COG1177	transmembrane transport
TBIS_RS05060	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
TBIS_RS05065	COG0640	Transcriptional regulator
TBIS_RS05080	COG1028	Short-chain dehydrogenase reductase Sdr
TBIS_RS05110	COG3469	chitinase activity
TBIS_RS05120	COG0628	permease
TBIS_RS05160	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
TBIS_RS05170	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
TBIS_RS05195	COG1012	belongs to the aldehyde dehydrogenase family
TBIS_RS05215	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
TBIS_RS05230	COG1309	transcriptional regulator
TBIS_RS05235	COG2409	Drug exporters of the RND superfamily
TBIS_RS05265	COG2188	Transcriptional regulator
TBIS_RS05285	COG0442	prolyl-tRNA aminoacylation
TBIS_RS05300	COG0779	Required for maturation of 30S ribosomal subunits
TBIS_RS05310	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
TBIS_RS05320	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
TBIS_RS05325	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
TBIS_RS05330	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
TBIS_RS05340	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
TBIS_RS05345	COG1185	polyribonucleotide nucleotidyltransferase activity
TBIS_RS05350	COG0612	Peptidase, M16
TBIS_RS05355	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
TBIS_RS05375	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
TBIS_RS05385	COG2188	Transcriptional regulator
TBIS_RS05390	COG2003	Belongs to the UPF0758 family
TBIS_RS05405	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
TBIS_RS05410	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
TBIS_RS05420	COG4948	Mandelate Racemase Muconate Lactonizing
TBIS_RS05425	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
TBIS_RS05430	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
TBIS_RS05440	COG3866	Pectate lyase
TBIS_RS05450	COG0395	ABC-type sugar transport system, permease component
TBIS_RS05460	COG4948	Mandelate Racemase Muconate Lactonizing
TBIS_RS05465	COG1414	Transcriptional regulator
TBIS_RS05470	COG1674	ftsk spoiiie
TBIS_RS05480	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TBIS_RS05490	COG1058	Belongs to the CinA family
TBIS_RS05490	COG1546	Belongs to the CinA family
TBIS_RS05495	COG1396	sequence-specific DNA binding
TBIS_RS05500	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
TBIS_RS05510	COG1940	carbohydrate kinase activity
TBIS_RS05515	COG1472	Belongs to the glycosyl hydrolase 3 family
TBIS_RS05520	COG0395	ABC-type sugar transport system, permease component
TBIS_RS05525	COG1175	transmembrane transport
TBIS_RS05570	COG1201	RNA secondary structure unwinding
TBIS_RS05580	COG4152	abc transporter atp-binding protein
TBIS_RS05585	COG1668	transmembrane transport
TBIS_RS05595	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
TBIS_RS05600	COG2137	regulation of response to DNA damage stimulus
TBIS_RS05605	COG1418	mRNA catabolic process
TBIS_RS05615	COG0765	amino acid transport
TBIS_RS05620	COG0765	amino acid transport
TBIS_RS05625	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
TBIS_RS05630	COG1126	abc transporter atp-binding protein
TBIS_RS05635	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TBIS_RS05645	COG1234	tRNA 3'-trailer cleavage
TBIS_RS05655	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
TBIS_RS05660	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
TBIS_RS05685	COG0247	lactate metabolic process
TBIS_RS05690	COG0277	FAD linked oxidase domain protein
TBIS_RS05695	COG0277	FAD linked oxidase domain protein
TBIS_RS05700	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
TBIS_RS05705	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
TBIS_RS05715	COG1596	polysaccharide export
TBIS_RS05715	COG1555	photosystem II stabilization
TBIS_RS05730	COG0268	Binds directly to 16S ribosomal RNA
TBIS_RS05735	COG0481	GTPase activity
TBIS_RS05740	COG2258	MOSC domain
TBIS_RS05755	COG1420	regulation of RNA biosynthetic process
TBIS_RS05760	COG0484	heat shock protein binding
TBIS_RS05780	COG0537	adenosine 5'-monophosphoramidase activity
TBIS_RS05790	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
TBIS_RS05810	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
TBIS_RS05820	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
TBIS_RS05835	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
TBIS_RS05840	COG1834	amidinotransferase
TBIS_RS05845	COG1522	sequence-specific DNA binding
TBIS_RS05850	COG0583	DNA-binding transcription factor activity
TBIS_RS05875	COG1381	Involved in DNA repair and RecF pathway recombination
TBIS_RS05880	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
TBIS_RS05905	COG0423	glycine-tRNA ligase activity
TBIS_RS05915	COG0574	Belongs to the PEP-utilizing enzyme family
TBIS_RS05915	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
TBIS_RS05920	COG0232	Belongs to the dGTPase family. Type 2 subfamily
TBIS_RS05930	COG0358	DNA primase activity
TBIS_RS05935	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
TBIS_RS05955	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
TBIS_RS05960	COG2188	Transcriptional regulator
TBIS_RS05970	COG1129	ABC transporter
TBIS_RS05990	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
TBIS_RS05995	COG1070	Carbohydrate kinase
TBIS_RS06025	COG1131	(ABC) transporter
TBIS_RS06030	COG2188	Transcriptional regulator
TBIS_RS06035	COG1028	Short-chain dehydrogenase reductase Sdr
TBIS_RS06045	COG1309	transcriptional regulator
TBIS_RS06065	COG0730	response to heat
TBIS_RS06070	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
TBIS_RS06075	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TBIS_RS06110	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
TBIS_RS06120	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
TBIS_RS06165	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
TBIS_RS06170	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TBIS_RS06175	COG1120	ATPase activity
TBIS_RS06210	COG1529	Aldehyde oxidase and xanthine dehydrogenase
TBIS_RS06255	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
TBIS_RS06265	COG0477	Major facilitator Superfamily
TBIS_RS06270	COG1309	transcriptional regulator
TBIS_RS06275	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
TBIS_RS06275	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
TBIS_RS06290	COG2814	Major facilitator Superfamily
TBIS_RS06300	COG0174	glutamine synthetase
TBIS_RS06310	COG0505	Belongs to the CarA family
TBIS_RS06315	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
TBIS_RS06330	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
TBIS_RS06340	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
TBIS_RS06345	COG0321	lipoyl(octanoyl) transferase activity
TBIS_RS06350	COG3340	Belongs to the peptidase S51 family
TBIS_RS06360	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
TBIS_RS06365	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
TBIS_RS06370	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
TBIS_RS06385	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
TBIS_RS06400	COG0667	Aldo Keto reductase
TBIS_RS06420	COG0501	Belongs to the peptidase M48B family
TBIS_RS06430	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
TBIS_RS06440	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
TBIS_RS06455	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
TBIS_RS06460	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
TBIS_RS06470	COG1376	ErfK ybiS ycfS ynhG family protein
TBIS_RS06475	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
TBIS_RS06480	COG0723	plastoquinol--plastocyanin reductase activity
TBIS_RS06490	COG1845	cytochrome c oxidase, subunit III
TBIS_RS06500	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
TBIS_RS06525	COG1388	LysM domain
TBIS_RS06525	COG0791	NLP P60 protein
TBIS_RS06550	COG1940	carbohydrate kinase activity
TBIS_RS06575	COG0204	Acyl-transferase
TBIS_RS06585	COG2040	homocysteine
TBIS_RS06620	COG4521	taurine ABC transporter
TBIS_RS06625	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
TBIS_RS06630	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
TBIS_RS06635	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
TBIS_RS06640	COG0205	6-phosphofructokinase activity
TBIS_RS06645	COG0301	tRNA thio-modification
TBIS_RS06650	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
TBIS_RS06655	COG3275	phosphorelay sensor kinase activity
TBIS_RS06660	COG3279	Response regulator of the LytR AlgR family
TBIS_RS06665	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
TBIS_RS06695	COG0515	serine threonine protein kinase
TBIS_RS06695	COG2815	serine threonine protein kinase
TBIS_RS06700	COG2022	thiamine diphosphate biosynthetic process
TBIS_RS06710	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
TBIS_RS06710	COG2022	thiamine diphosphate biosynthetic process
TBIS_RS06725	COG0352	thiamine-phosphate diphosphorylase activity
TBIS_RS06730	COG0142	geranyltranstransferase activity
TBIS_RS06750	COG0860	N-Acetylmuramoyl-L-alanine amidase
TBIS_RS06750	COG3409	Peptidoglycan-binding domain 1 protein
TBIS_RS06765	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
TBIS_RS06770	COG0540	Belongs to the ATCase OTCase family
TBIS_RS06775	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
TBIS_RS06780	COG0505	Belongs to the CarA family
TBIS_RS06785	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
TBIS_RS06790	COG0543	2 iron, 2 sulfur cluster binding
TBIS_RS06795	COG0167	dihydroorotate dehydrogenase activity
TBIS_RS06800	COG0284	orotidine-5'-phosphate decarboxylase activity
TBIS_RS06810	COG0194	GDP metabolic process
TBIS_RS06815	COG1758	RNA polymerase activity
TBIS_RS06825	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
TBIS_RS06845	COG0242	peptide deformylase activity
TBIS_RS06850	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
TBIS_RS06860	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
TBIS_RS06865	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
TBIS_RS06865	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
TBIS_RS06875	COG3201	nicotinamide mononucleotide transporter
TBIS_RS06880	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
TBIS_RS06880	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
TBIS_RS06885	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
TBIS_RS06900	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
TBIS_RS06905	COG1116	anion transmembrane transporter activity
TBIS_RS06910	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
TBIS_RS06925	COG0542	response to heat
TBIS_RS06950	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
TBIS_RS06960	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
TBIS_RS06965	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
TBIS_RS06975	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
TBIS_RS06985	COG1305	Transglutaminase-like
TBIS_RS06995	COG0714	Associated with various cellular activities
TBIS_RS07000	COG2001	Belongs to the MraZ family
TBIS_RS07005	COG0275	rRNA processing
TBIS_RS07015	COG0768	penicillin binding
TBIS_RS07020	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
TBIS_RS07030	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
TBIS_RS07035	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
TBIS_RS07045	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
TBIS_RS07050	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
TBIS_RS07055	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
TBIS_RS07060	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
TBIS_RS07070	COG1799	cell septum assembly
TBIS_RS07090	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
TBIS_RS07095	COG1872	DUF167
TBIS_RS07105	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
TBIS_RS07120	COG0210	DNA helicase
TBIS_RS07135	COG0587	DNA-directed DNA polymerase activity
TBIS_RS07145	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
TBIS_RS07155	COG0154	amidase activity
TBIS_RS07160	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
TBIS_RS07165	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
TBIS_RS07175	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
TBIS_RS07180	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
TBIS_RS07185	COG0131	Imidazoleglycerol-phosphate dehydratase
TBIS_RS07190	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
TBIS_RS07195	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
TBIS_RS07200	COG0251	oxidation-reduction process
TBIS_RS07205	COG0107	imidazoleglycerol-phosphate synthase activity
TBIS_RS07220	COG1132	(ABC) transporter
TBIS_RS07225	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
TBIS_RS07245	COG0134	indole-3-glycerol-phosphate synthase activity
TBIS_RS07250	COG0133	tryptophan synthase activity
TBIS_RS07255	COG0159	tryptophan synthase activity
TBIS_RS07270	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
TBIS_RS07280	COG0070	glutamate synthase
TBIS_RS07280	COG0069	glutamate synthase activity
TBIS_RS07280	COG0067	glutamate synthase
TBIS_RS07310	COG0559	Belongs to the binding-protein-dependent transport system permease family
TBIS_RS07315	COG0411	ABC transporter
TBIS_RS07340	COG0683	leucine binding
TBIS_RS07365	COG2050	protein possibly involved in aromatic compounds catabolism
TBIS_RS07380	COG0539	negative regulation of cytoplasmic translation
TBIS_RS07390	COG0237	dephospho-CoA kinase activity
TBIS_RS07410	COG0556	nucleotide-excision repair
TBIS_RS07415	COG0110	maltose O-acetyltransferase activity
TBIS_RS07420	COG0504	CTP synthase activity
TBIS_RS07440	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
TBIS_RS07445	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
TBIS_RS07465	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
TBIS_RS07470	COG1160	GTP binding
TBIS_RS07475	COG0477	Major facilitator Superfamily
TBIS_RS07535	COG1012	belongs to the aldehyde dehydrogenase family
TBIS_RS07540	COG0506	proline dehydrogenase activity
TBIS_RS07550	COG0297	glycogen (starch) synthase activity
TBIS_RS07560	COG1252	NADH dehydrogenase
TBIS_RS07605	COG0494	nUDIX hydrolase
TBIS_RS07625	COG1518	maintenance of DNA repeat elements
TBIS_RS07660	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
TBIS_RS07670	COG0443	Heat shock 70 kDa protein
TBIS_RS07690	COG0515	serine threonine protein kinase
TBIS_RS07720	COG0531	amino acid
TBIS_RS07730	COG0804	urea catabolic process
TBIS_RS07735	COG0832	Belongs to the urease beta subunit family
TBIS_RS07735	COG0831	urea catabolic process
TBIS_RS07740	COG1609	Transcriptional regulator
TBIS_RS07745	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
TBIS_RS07750	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
TBIS_RS07755	COG1116	anion transmembrane transporter activity
TBIS_RS07760	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
TBIS_RS07765	COG3693	PFAM glycoside hydrolase, family 10
TBIS_RS07775	COG1653	transport
TBIS_RS07780	COG0395	ABC-type sugar transport system, permease component
TBIS_RS07785	COG4209	transmembrane transport
TBIS_RS07830	COG1966	Carbon starvation protein
TBIS_RS07855	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
TBIS_RS07890	COG1028	Short-chain dehydrogenase reductase Sdr
TBIS_RS07900	COG1960	acyl-CoA dehydrogenase activity
TBIS_RS07905	COG3842	ATPase activity
TBIS_RS07910	COG1177	transmembrane transport
TBIS_RS07915	COG1176	ABC-type spermidine putrescine transport system, permease component I
TBIS_RS07935	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
TBIS_RS07940	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
TBIS_RS07945	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
TBIS_RS07950	COG2855	membrane
TBIS_RS07970	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TBIS_RS07985	COG0318	PFAM AMP-dependent synthetase and ligase
TBIS_RS07995	COG0431	NADPH-dependent FMN reductase
TBIS_RS08005	COG1028	Short-chain dehydrogenase reductase Sdr
TBIS_RS08015	COG1028	Short-chain dehydrogenase reductase Sdr
TBIS_RS08030	COG0477	Major facilitator Superfamily
TBIS_RS08055	COG1703	isobutyryl-CoA mutase activity
TBIS_RS08055	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
TBIS_RS08055	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
TBIS_RS08060	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TBIS_RS08065	COG2197	response regulator
TBIS_RS08070	COG1120	ATPase activity
TBIS_RS08075	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TBIS_RS08080	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TBIS_RS08105	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
TBIS_RS08110	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
TBIS_RS08110	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
TBIS_RS08130	COG1960	acyl-CoA dehydrogenase activity
TBIS_RS08135	COG1309	transcriptional regulator
TBIS_RS08155	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
TBIS_RS08210	COG2217	Heavy metal translocating P-type atpase
TBIS_RS08215	COG4109	DRTGG domain
TBIS_RS08230	COG2132	Multicopper oxidase
TBIS_RS08250	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
TBIS_RS08260	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TBIS_RS08270	COG4608	Belongs to the ABC transporter superfamily
TBIS_RS08280	COG3876	Protein conserved in bacteria
TBIS_RS08285	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
TBIS_RS08290	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
TBIS_RS08310	COG1515	deoxyribonuclease V activity
TBIS_RS08315	COG0435	Glutathione S-transferase
TBIS_RS08355	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
TBIS_RS08360	COG2183	response to ionizing radiation
TBIS_RS08380	COG0772	Belongs to the SEDS family
TBIS_RS08385	COG0768	penicillin binding
TBIS_RS08390	COG1792	Involved in formation and maintenance of cell shape
TBIS_RS08420	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
TBIS_RS08425	COG1716	ATPase activity
TBIS_RS08445	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
TBIS_RS08445	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
TBIS_RS08495	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
TBIS_RS08500	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
TBIS_RS08510	COG2188	Transcriptional regulator
TBIS_RS08530	COG1132	(ABC) transporter
TBIS_RS08535	COG4988	ABC transporter
TBIS_RS08545	COG1739	Uncharacterized protein family UPF0029
TBIS_RS08550	COG1169	isochorismate synthase
TBIS_RS08565	COG2197	response regulator
TBIS_RS08570	COG4585	Histidine kinase
TBIS_RS08580	COG1131	(ABC) transporter
TBIS_RS08585	COG0438	transferase activity, transferring glycosyl groups
TBIS_RS08610	COG2261	transglycosylase associated protein
TBIS_RS08660	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
TBIS_RS08665	COG1012	belongs to the aldehyde dehydrogenase family
TBIS_RS08670	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
TBIS_RS08685	COG1960	acyl-CoA dehydrogenase activity
TBIS_RS08700	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
TBIS_RS08705	COG0022	dehydrogenase e1 component
TBIS_RS08710	COG0508	dehydrogenase complex catalyzes the overall conversion of
TBIS_RS08715	COG0475	glutathione-regulated potassium exporter activity
TBIS_RS08740	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
TBIS_RS08745	COG1376	ErfK ybiS ycfS ynhG family protein
TBIS_RS08765	COG2076	Multidrug Resistance protein
TBIS_RS08775	COG0842	Transport permease protein
TBIS_RS08785	COG1131	(ABC) transporter
TBIS_RS08800	COG4565	transcriptional regulatory protein
TBIS_RS08810	COG2197	response regulator
TBIS_RS08825	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
TBIS_RS08830	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
TBIS_RS08850	COG4974	Belongs to the 'phage' integrase family
TBIS_RS08855	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
TBIS_RS08865	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
TBIS_RS08870	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
TBIS_RS08890	COG1280	lysine exporter protein (LysE YggA)
TBIS_RS08900	COG2223	nitrite transmembrane transporter activity
TBIS_RS08915	COG0714	Associated with various cellular activities
TBIS_RS08930	COG2813	Specifically methylates the guanine in position
TBIS_RS08935	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
TBIS_RS08940	COG0584	glycerophosphoryl diester phosphodiesterase
TBIS_RS08955	COG0583	DNA-binding transcription factor activity
TBIS_RS08960	COG1960	acyl-CoA dehydrogenase activity
TBIS_RS08975	COG0463	Glycosyl transferase, family 2
TBIS_RS08990	COG1522	sequence-specific DNA binding
TBIS_RS08995	COG1960	acyl-CoA dehydrogenase activity
TBIS_RS09015	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
TBIS_RS09030	COG0805	protein transport
TBIS_RS09035	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
TBIS_RS09060	COG0545	Peptidyl-prolyl cis-trans isomerase
TBIS_RS09065	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
TBIS_RS09075	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
TBIS_RS09080	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
TBIS_RS09095	COG4122	O-methyltransferase activity
TBIS_RS09105	COG1222	aaa ATPase
TBIS_RS09115	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
TBIS_RS09130	COG1994	Peptidase M50
TBIS_RS09130	COG0517	IMP dehydrogenase activity
TBIS_RS09145	COG4585	Histidine kinase
TBIS_RS09150	COG2197	response regulator
TBIS_RS09155	COG4608	Belongs to the ABC transporter superfamily
TBIS_RS09160	COG0444	Belongs to the ABC transporter superfamily
TBIS_RS09175	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TBIS_RS09185	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
TBIS_RS09190	COG1410	methionine synthase
TBIS_RS09190	COG0646	methionine synthase
TBIS_RS09200	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
TBIS_RS09220	COG0543	2 iron, 2 sulfur cluster binding
TBIS_RS09235	COG0463	Glycosyl transferase, family 2
TBIS_RS09330	COG0366	Alpha amylase catalytic
TBIS_RS09335	COG3833	ABC-type maltose transport systems, permease component
TBIS_RS09360	COG2205	protein histidine kinase activity
TBIS_RS09365	COG3119	arylsulfatase activity
TBIS_RS09375	COG1175	transmembrane transport
TBIS_RS09380	COG0395	ABC-type sugar transport system, permease component
TBIS_RS09385	COG2723	6-phospho-beta-galactosidase activity
TBIS_RS09395	COG2723	6-phospho-beta-galactosidase activity
TBIS_RS09400	COG2017	converts alpha-aldose to the beta-anomer
TBIS_RS09405	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
TBIS_RS09410	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
TBIS_RS09420	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
TBIS_RS09425	COG0589	response to stress
TBIS_RS09435	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TBIS_RS09445	COG1464	Belongs to the NlpA lipoprotein family
TBIS_RS09450	COG2011	ABC-type metal ion transport system permease component
TBIS_RS09455	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
TBIS_RS09465	COG3540	Alkaline phosphatase
TBIS_RS09485	COG0672	)-iron permease
TBIS_RS09495	COG2837	iron assimilation
TBIS_RS09525	COG4133	protoheme IX ABC transporter activity
TBIS_RS09570	COG0215	cysteine-tRNA ligase activity
TBIS_RS09595	COG1968	undecaprenyl-diphosphatase activity
TBIS_RS09600	COG0667	Aldo Keto reductase
TBIS_RS09610	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
TBIS_RS09615	COG1028	Short-chain dehydrogenase reductase Sdr
TBIS_RS09630	COG3360	Dodecin
TBIS_RS09635	COG0746	molybdenum cofactor guanylyltransferase activity
TBIS_RS09640	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
TBIS_RS09675	COG3104	oligopeptide transport
TBIS_RS09680	COG3387	PFAM Glycoside hydrolase 15-related
TBIS_RS09685	COG1619	proteins homologs of microcin C7 resistance protein MccF
TBIS_RS09695	COG1132	(ABC) transporter
TBIS_RS09710	COG0488	(ABC) transporter
TBIS_RS09720	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
TBIS_RS09725	COG0140	phosphoribosyl-ATP diphosphatase activity
TBIS_RS09730	COG3458	cephalosporin-C deacetylase activity
TBIS_RS09735	COG2151	metal-sulfur cluster biosynthetic enzyme
TBIS_RS09740	COG0822	iron-sulfur transferase activity
TBIS_RS09745	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
TBIS_RS09750	COG0396	ATPase activity
TBIS_RS09755	COG2146	nitrite reductase [NAD(P)H] activity
TBIS_RS09760	COG0719	Fe-S assembly protein
TBIS_RS09775	COG1131	(ABC) transporter
TBIS_RS09785	COG5006	permease, DMT superfamily
TBIS_RS09800	COG0109	protoheme IX farnesyltransferase activity
TBIS_RS09810	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
TBIS_RS09815	COG0166	Belongs to the GPI family
TBIS_RS09830	COG0363	glucosamine-6-phosphate deaminase activity
TBIS_RS09835	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
TBIS_RS09835	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
TBIS_RS09840	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
TBIS_RS09855	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
TBIS_RS09860	COG0149	triose-phosphate isomerase activity
TBIS_RS09865	COG0126	phosphoglycerate kinase activity
TBIS_RS09870	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
TBIS_RS09875	COG1481	regulation of sporulation
TBIS_RS09885	COG1660	Displays ATPase and GTPase activities
TBIS_RS09890	COG0322	excinuclease ABC activity
TBIS_RS09900	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
TBIS_RS09910	COG4948	Mandelate Racemase Muconate Lactonizing
TBIS_RS09925	COG0688	phosphatidylethanolamine metabolic process
TBIS_RS09935	COG0297	glycogen (starch) synthase activity
TBIS_RS09960	COG0497	DNA recombination
TBIS_RS09965	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
TBIS_RS09985	COG0647	UMP catabolic process
TBIS_RS10010	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
TBIS_RS10015	COG3401	FG-GAP repeat protein
TBIS_RS10020	COG2094	Belongs to the DNA glycosylase MPG family
TBIS_RS10025	COG0165	Argininosuccinate lyase
TBIS_RS10030	COG0137	argininosuccinate synthase activity
TBIS_RS10035	COG1438	arginine binding
TBIS_RS10040	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
TBIS_RS10045	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
TBIS_RS10050	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
TBIS_RS10055	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
TBIS_RS10060	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
TBIS_RS10065	COG0318	PFAM AMP-dependent synthetase and ligase
TBIS_RS10085	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TBIS_RS10085	COG0072	phenylalanine-tRNA ligase activity
TBIS_RS10090	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
TBIS_RS10095	COG5002	protein histidine kinase activity
TBIS_RS10100	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
TBIS_RS10105	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
TBIS_RS10115	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
TBIS_RS10120	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
TBIS_RS10125	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
TBIS_RS10135	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
TBIS_RS10140	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
TBIS_RS10165	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
TBIS_RS10170	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
TBIS_RS10175	COG0124	histidyl-tRNA synthetase
TBIS_RS10185	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
TBIS_RS10190	COG1196	nuclear chromosome segregation
TBIS_RS10200	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
TBIS_RS10205	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
TBIS_RS10210	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
TBIS_RS10215	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
TBIS_RS10220	COG1862	Preprotein translocase
TBIS_RS10225	COG2255	four-way junction helicase activity
TBIS_RS10230	COG0632	four-way junction helicase activity
TBIS_RS10235	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
TBIS_RS10240	COG0217	transcriptional regulatory protein
TBIS_RS10245	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
TBIS_RS10255	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
TBIS_RS10270	COG0438	transferase activity, transferring glycosyl groups
TBIS_RS10275	COG1560	Kdo2-lipid A biosynthetic process
TBIS_RS10280	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
TBIS_RS10290	COG1649	PFAM Uncharacterised BCR, COG1649
TBIS_RS10300	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
TBIS_RS10305	COG0667	Aldo Keto reductase
TBIS_RS10325	COG0318	PFAM AMP-dependent synthetase and ligase
TBIS_RS10330	COG2197	response regulator
TBIS_RS10345	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
TBIS_RS10355	COG1733	regulation of RNA biosynthetic process
TBIS_RS10360	COG1804	L-carnitine dehydratase bile acid-inducible protein F
TBIS_RS10365	COG1024	Enoyl-CoA hydratase
TBIS_RS10370	COG1960	acyl-CoA dehydrogenase activity
TBIS_RS10375	COG1804	L-carnitine dehydratase bile acid-inducible protein F
TBIS_RS10400	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
TBIS_RS10405	COG0512	Glutamine amidotransferase of anthranilate synthase
TBIS_RS10405	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
TBIS_RS10410	COG0583	DNA-binding transcription factor activity
TBIS_RS10420	COG2986	histidine ammonia-lyase
TBIS_RS10445	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
TBIS_RS10455	COG1309	transcriptional regulator
TBIS_RS10470	COG3851	Histidine kinase
TBIS_RS10495	COG2124	cytochrome p450
TBIS_RS10505	COG0297	glycogen (starch) synthase activity
TBIS_RS10510	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
TBIS_RS10520	COG1024	Enoyl-CoA hydratase
TBIS_RS10530	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
TBIS_RS10560	COG0243	molybdopterin cofactor binding
TBIS_RS10575	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
TBIS_RS10580	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
TBIS_RS10580	COG1796	DNA polymerase
TBIS_RS10595	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
TBIS_RS10605	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
TBIS_RS10615	COG3279	Response regulator of the LytR AlgR family
TBIS_RS10620	COG3275	phosphorelay sensor kinase activity
TBIS_RS10655	COG1597	lipid kinase activity
TBIS_RS10665	COG0277	FAD linked oxidase domain protein
TBIS_RS10670	COG1024	Enoyl-CoA hydratase
TBIS_RS10685	COG2313	pseudouridylate synthase activity
TBIS_RS10705	COG1960	acyl-CoA dehydrogenase activity
TBIS_RS10720	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
TBIS_RS10730	COG0022	dehydrogenase e1 component
TBIS_RS10785	COG0419	ATPase involved in DNA repair
TBIS_RS10790	COG0420	3'-5' exonuclease activity
TBIS_RS10800	COG1316	TRANSCRIPTIONal
TBIS_RS10805	COG4948	Mandelate Racemase Muconate Lactonizing
TBIS_RS10810	COG3552	Protein containing von Willebrand factor type A (VWA) domain
TBIS_RS10820	COG0714	Associated with various cellular activities
TBIS_RS10835	COG1012	belongs to the aldehyde dehydrogenase family
TBIS_RS10895	COG3842	ATPase activity
TBIS_RS10940	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
TBIS_RS10945	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
TBIS_RS10950	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
TBIS_RS10955	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
TBIS_RS10975	COG0549	Belongs to the carbamate kinase family
TBIS_RS10980	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
TBIS_RS10985	COG0450	alkyl hydroperoxide reductase
TBIS_RS11000	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
TBIS_RS11055	COG2233	PERMEase
TBIS_RS11070	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
TBIS_RS11075	COG1304	FMN binding
TBIS_RS11090	COG0277	FAD linked oxidase domain protein
TBIS_RS11110	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
TBIS_RS11120	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
TBIS_RS11130	COG0175	sulfate reduction
TBIS_RS11155	COG1960	acyl-CoA dehydrogenase activity
TBIS_RS11180	COG1793	dna ligase
TBIS_RS11195	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
TBIS_RS11205	COG3253	May function as heme-dependent peroxidase
TBIS_RS11210	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
TBIS_RS11220	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
TBIS_RS11230	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
TBIS_RS11235	COG0183	Belongs to the thiolase family
TBIS_RS11240	COG1024	Enoyl-CoA hydratase
TBIS_RS11240	COG1250	3-hydroxyacyl-CoA dehydrogenase
TBIS_RS11245	COG0531	amino acid
TBIS_RS11250	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
TBIS_RS11260	COG4214	carbohydrate transport
TBIS_RS11270	COG4213	ABC transporter substrate-binding protein
TBIS_RS11280	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
TBIS_RS11315	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
TBIS_RS11320	COG0531	amino acid
TBIS_RS11325	COG0569	domain protein
TBIS_RS11350	COG0756	dUTP diphosphatase activity
TBIS_RS11360	COG0525	valine-tRNA ligase activity
TBIS_RS11370	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
TBIS_RS11385	COG2205	protein histidine kinase activity
TBIS_RS11390	COG0745	RESPONSE REGULATOR receiver
TBIS_RS11405	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
TBIS_RS11410	COG0739	heme binding
TBIS_RS11440	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
TBIS_RS11460	COG1579	Zn-ribbon protein possibly nucleic acid-binding
TBIS_RS11465	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
TBIS_RS11470	COG2205	protein histidine kinase activity
TBIS_RS11485	COG0300	oxidoreductase activity
TBIS_RS11495	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
TBIS_RS11500	COG1609	Transcriptional regulator
TBIS_RS11550	COG1643	Atp-dependent helicase
TBIS_RS11555	COG0745	RESPONSE REGULATOR receiver
TBIS_RS11595	COG1404	Belongs to the peptidase S8 family
TBIS_RS11610	COG3173	Aminoglycoside phosphotransferase
TBIS_RS11630	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
TBIS_RS11690	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
TBIS_RS11710	COG3766	membrane
TBIS_RS11720	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
TBIS_RS11740	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
TBIS_RS11745	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
TBIS_RS11815	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
TBIS_RS11825	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
TBIS_RS11860	COG0187	DNA topoisomerase II activity
TBIS_RS11875	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
TBIS_RS11875	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
TBIS_RS11880	COG5001	Diguanylate cyclase
TBIS_RS11890	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
TBIS_RS11910	COG1609	Transcriptional regulator
TBIS_RS11915	COG1472	Belongs to the glycosyl hydrolase 3 family
TBIS_RS11920	COG1940	carbohydrate kinase activity
TBIS_RS11955	COG1472	Belongs to the glycosyl hydrolase 3 family
TBIS_RS11960	COG0395	ABC-type sugar transport system, permease component
TBIS_RS11975	COG1501	Belongs to the glycosyl hydrolase 31 family
TBIS_RS12010	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
TBIS_RS12015	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
TBIS_RS12020	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
TBIS_RS12025	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
TBIS_RS12030	COG0495	leucyl-tRNA aminoacylation
TBIS_RS12045	COG0318	PFAM AMP-dependent synthetase and ligase
TBIS_RS12050	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
TBIS_RS12100	COG0424	maF-like protein
TBIS_RS12115	COG1492	cobalamin metabolic process
TBIS_RS12125	COG1028	Short-chain dehydrogenase reductase Sdr
TBIS_RS12155	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
TBIS_RS12160	COG0501	Belongs to the peptidase M48B family
TBIS_RS12170	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
TBIS_RS12175	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
TBIS_RS12180	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
TBIS_RS12185	COG0211	Belongs to the bacterial ribosomal protein bL27 family
TBIS_RS12190	COG0261	This protein binds to 23S rRNA in the presence of protein L20
TBIS_RS12195	COG1530	ribonuclease E activity
TBIS_RS12210	COG0772	Belongs to the SEDS family
TBIS_RS12215	COG0768	penicillin binding
TBIS_RS12230	COG1077	Cell shape determining protein MreB Mrl
TBIS_RS12235	COG0105	UTP biosynthetic process
TBIS_RS12250	COG0285	dihydrofolate synthase activity
TBIS_RS12260	COG0525	valine-tRNA ligase activity
TBIS_RS12265	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
TBIS_RS12270	COG0740	serine-type endopeptidase activity
TBIS_RS12275	COG0740	serine-type endopeptidase activity
TBIS_RS12280	COG0544	peptidyl-prolyl cis-trans isomerase activity
TBIS_RS12300	COG1434	Gram-negative-bacterium-type cell wall biogenesis
TBIS_RS12340	COG1797	cobyrinic acid a,c-diamide synthase activity
TBIS_RS12345	COG1799	cell septum assembly
TBIS_RS12420	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
TBIS_RS12430	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
TBIS_RS12460	COG0318	PFAM AMP-dependent synthetase and ligase
TBIS_RS12470	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
TBIS_RS12495	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
TBIS_RS12505	COG1028	Short-chain dehydrogenase reductase Sdr
TBIS_RS12525	COG0750	zinc metalloprotease
TBIS_RS12545	COG0242	peptide deformylase activity
TBIS_RS12565	COG0154	amidase activity
TBIS_RS12575	COG0129	dihydroxy-acid dehydratase activity
TBIS_RS12600	COG1505	serine-type exopeptidase activity
TBIS_RS12630	COG0668	transmembrane transport
TBIS_RS12675	COG0629	single-stranded DNA binding
TBIS_RS12690	COG1648	precorrin-2 dehydrogenase activity
TBIS_RS12690	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
TBIS_RS12695	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
TBIS_RS12720	COG0583	DNA-binding transcription factor activity
TBIS_RS12735	COG0587	DNA-directed DNA polymerase activity
TBIS_RS12750	COG3848	Pyruvate phosphate dikinase
TBIS_RS12750	COG0574	Belongs to the PEP-utilizing enzyme family
TBIS_RS12765	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
TBIS_RS12790	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
TBIS_RS12795	COG1609	Transcriptional regulator
TBIS_RS12810	COG1172	Belongs to the binding-protein-dependent transport system permease family
TBIS_RS12830	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
TBIS_RS12835	COG4266	Belongs to the allantoicase family
TBIS_RS12840	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
TBIS_RS12845	COG1929	Belongs to the glycerate kinase type-1 family
TBIS_RS12890	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
TBIS_RS12895	COG1984	allophanate hydrolase subunit 2
TBIS_RS12905	COG1760	l-serine dehydratase
TBIS_RS12910	COG2723	6-phospho-beta-galactosidase activity
TBIS_RS12915	COG1012	belongs to the aldehyde dehydrogenase family
TBIS_RS12920	COG0028	Belongs to the TPP enzyme family
TBIS_RS12925	COG0477	Major facilitator Superfamily
TBIS_RS12935	COG0804	urea catabolic process
TBIS_RS12940	COG0832	Belongs to the urease beta subunit family
TBIS_RS12940	COG0831	urea catabolic process
TBIS_RS12960	COG3608	succinylglutamate desuccinylase aspartoacylase
TBIS_RS12960	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
TBIS_RS12970	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
TBIS_RS12980	COG0375	protein maturation
TBIS_RS13010	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
TBIS_RS13025	COG1595	DNA-templated transcription, initiation
TBIS_RS13030	COG2852	Protein conserved in bacteria
TBIS_RS13070	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
TBIS_RS13085	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
TBIS_RS13085	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
TBIS_RS13090	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
TBIS_RS13095	COG0297	glycogen (starch) synthase activity
TBIS_RS13100	COG0859	PFAM glycosyl transferase family 9
TBIS_RS13110	COG2192	nodulation
TBIS_RS13115	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
TBIS_RS13135	COG0121	glutamine amidotransferase
TBIS_RS13140	COG1262	PFAM Formylglycine-generating sulfatase enzyme
TBIS_RS13145	COG3572	ergothioneine biosynthetic process
TBIS_RS13160	COG0640	Transcriptional regulator
TBIS_RS13170	COG5297	Belongs to the glycosyl hydrolase family 6
TBIS_RS13185	COG0039	L-malate dehydrogenase activity
TBIS_RS13210	COG0215	cysteine-tRNA ligase activity
TBIS_RS13220	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
TBIS_RS13230	COG3629	intracellular signal transduction
TBIS_RS13230	COG3903	Transcriptional regulator
TBIS_RS13265	COG0726	polysaccharide deacetylase
TBIS_RS13265	COG1649	PFAM Uncharacterised BCR, COG1649
TBIS_RS13285	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
TBIS_RS13295	COG2197	response regulator
TBIS_RS13325	COG0477	Major facilitator Superfamily
TBIS_RS13340	COG0725	ABC transporter, periplasmic molybdate-binding protein
TBIS_RS13350	COG0783	Belongs to the Dps family
TBIS_RS13380	COG1960	acyl-CoA dehydrogenase activity
TBIS_RS13385	COG1960	acyl-CoA dehydrogenase activity
TBIS_RS13390	COG1960	acyl-CoA dehydrogenase activity
TBIS_RS13410	COG0653	protein targeting
TBIS_RS13420	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
TBIS_RS13445	COG0517	IMP dehydrogenase activity
TBIS_RS13445	COG0516	GMP reductase activity
TBIS_RS13450	COG2239	Acts as a magnesium transporter
TBIS_RS13460	COG1653	transport
TBIS_RS13470	COG0395	ABC-type sugar transport system, permease component
TBIS_RS13520	COG0210	DNA helicase
TBIS_RS13525	COG1111	helicase
TBIS_RS13525	COG1205	dead DEAH box helicase
TBIS_RS13530	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
TBIS_RS13535	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
TBIS_RS13540	COG2814	Major facilitator Superfamily
TBIS_RS13550	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
TBIS_RS13615	COG1294	oxidase, subunit
TBIS_RS13620	COG1271	oxidase subunit
TBIS_RS13640	COG2130	NADP-dependent
TBIS_RS13645	COG1950	PFAM Membrane protein of
TBIS_RS13655	COG2807	transmembrane transport
TBIS_RS13670	COG1414	Transcriptional regulator
TBIS_RS13675	COG0667	Aldo Keto reductase
TBIS_RS13700	COG1217	gtp-binding protein TYPA
TBIS_RS13710	COG0433	COG0433 Predicted ATPase
TBIS_RS13715	COG0726	polysaccharide deacetylase
TBIS_RS13720	COG1476	TRANSCRIPTIONal
TBIS_RS13730	COG1595	DNA-templated transcription, initiation
TBIS_RS13745	COG1196	nuclear chromosome segregation
TBIS_RS13755	COG1254	Belongs to the acylphosphatase family
TBIS_RS13760	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
TBIS_RS13765	COG0571	ribonuclease III activity
TBIS_RS13770	COG0333	Belongs to the bacterial ribosomal protein bL32 family
TBIS_RS13780	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
TBIS_RS13785	COG0742	ribosomal rna small subunit methyltransferase
TBIS_RS13795	COG0227	Belongs to the bacterial ribosomal protein bL28 family
TBIS_RS13800	COG0351	phosphomethylpyrimidine kinase
TBIS_RS13825	COG1181	Belongs to the D-alanine--D-alanine ligase family
TBIS_RS13830	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
TBIS_RS13840	COG1920	GTP binding
TBIS_RS13845	COG0477	Major facilitator Superfamily
TBIS_RS13860	COG0776	regulation of translation
TBIS_RS13865	COG0066	3-isopropylmalate dehydratase activity
TBIS_RS13870	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
TBIS_RS13875	COG1414	Transcriptional regulator
TBIS_RS13900	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
TBIS_RS13905	COG0179	Fumarylacetoacetate (FAA) hydrolase
TBIS_RS13920	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
TBIS_RS13930	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
TBIS_RS13935	COG0473	3-isopropylmalate dehydrogenase activity
TBIS_RS13940	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
TBIS_RS13950	COG2211	Major facilitator Superfamily
TBIS_RS13955	COG2340	Cysteine-rich secretory protein family
TBIS_RS13965	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
TBIS_RS13970	COG0440	acetolactate synthase activity
TBIS_RS13980	COG3300	MHYT domain
TBIS_RS13980	COG5001	Diguanylate cyclase
TBIS_RS13985	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
TBIS_RS13990	COG2133	pyrroloquinoline quinone binding
TBIS_RS14000	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
TBIS_RS14005	COG0154	amidase activity
TBIS_RS14010	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
TBIS_RS14030	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
TBIS_RS14035	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
TBIS_RS14040	COG3485	protocatechuate 3,4-dioxygenase
TBIS_RS14045	COG3485	protocatechuate 3,4-dioxygenase
TBIS_RS14050	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
TBIS_RS14055	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
TBIS_RS14060	COG1414	Transcriptional regulator
TBIS_RS14065	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
TBIS_RS14080	COG0482	sulfurtransferase activity
TBIS_RS14095	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
TBIS_RS14110	COG0515	serine threonine protein kinase
TBIS_RS14110	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
TBIS_RS14130	COG2362	D-Aminopeptidase
TBIS_RS14145	COG1024	Enoyl-CoA hydratase
TBIS_RS14150	COG0438	transferase activity, transferring glycosyl groups
TBIS_RS14160	COG0058	SHG alpha-glucan phosphorylase activity
TBIS_RS14165	COG0366	Alpha amylase catalytic
TBIS_RS14175	COG3281	Trehalose synthase
TBIS_RS14180	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
TBIS_RS14190	COG0616	signal peptide processing
TBIS_RS14215	COG0318	PFAM AMP-dependent synthetase and ligase
TBIS_RS14235	COG1309	transcriptional regulator
TBIS_RS14245	COG0438	transferase activity, transferring glycosyl groups
TBIS_RS14250	COG2226	methyltransferase
TBIS_RS14285	COG0673	inositol 2-dehydrogenase activity
TBIS_RS14290	COG4213	ABC transporter substrate-binding protein
TBIS_RS14295	COG1172	Belongs to the binding-protein-dependent transport system permease family
TBIS_RS14300	COG1129	ABC transporter
TBIS_RS14305	COG1940	carbohydrate kinase activity
TBIS_RS14330	COG0567	Dehydrogenase, E1 component
TBIS_RS14330	COG0508	dehydrogenase complex catalyzes the overall conversion of
TBIS_RS14345	COG0604	alcohol dehydrogenase
TBIS_RS14360	COG0488	(ABC) transporter
TBIS_RS14405	COG2172	sigma factor antagonist activity
TBIS_RS14435	COG2188	Transcriptional regulator
TBIS_RS14460	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
TBIS_RS14485	COG1595	DNA-templated transcription, initiation
TBIS_RS14500	COG2135	peptidase activity
TBIS_RS14505	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
TBIS_RS14515	COG0483	inositol monophosphate 1-phosphatase activity
TBIS_RS14530	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
TBIS_RS14545	COG0581	inorganic phosphate transmembrane transporter activity
TBIS_RS14550	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
TBIS_RS14570	COG0747	negative chemotaxis
TBIS_RS14610	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TBIS_RS14615	COG0601	transmembrane transport
TBIS_RS14620	COG0747	negative chemotaxis
TBIS_RS14650	COG1615	UPF0182 protein
TBIS_RS14655	COG3480	Lon protease (S16) C-terminal proteolytic domain
TBIS_RS14695	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
TBIS_RS14715	COG1946	Acyl-CoA thioesterase
TBIS_RS14745	COG4264	IucA IucC family
TBIS_RS14755	COG0019	diaminopimelate decarboxylase activity
TBIS_RS14765	COG0210	DNA helicase
TBIS_RS14770	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
TBIS_RS14785	COG1404	Belongs to the peptidase S8 family
TBIS_RS14795	COG1404	Belongs to the peptidase S8 family
TBIS_RS14845	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
TBIS_RS14850	COG3285	dna ligase
TBIS_RS14850	COG1793	dna ligase
TBIS_RS14875	COG0513	Belongs to the DEAD box helicase family
TBIS_RS14900	COG0494	nUDIX hydrolase
TBIS_RS14910	COG1266	CAAX protease self-immunity
TBIS_RS14915	COG2301	Belongs to the HpcH HpaI aldolase family
TBIS_RS14920	COG1268	BioY protein
TBIS_RS14940	COG2239	Acts as a magnesium transporter
TBIS_RS14955	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
TBIS_RS14975	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
TBIS_RS14985	COG1024	Enoyl-CoA hydratase
TBIS_RS14990	COG0519	Catalyzes the synthesis of GMP from XMP
TBIS_RS15005	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
TBIS_RS15015	COG1611	Belongs to the LOG family
TBIS_RS15045	COG4106	trans-aconitate 2-methyltransferase activity
TBIS_RS15055	COG0210	DNA helicase
TBIS_RS15065	COG0215	cysteine-tRNA ligase activity
TBIS_RS15075	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
TBIS_RS15140	COG1053	succinate dehydrogenase
TBIS_RS15155	COG0494	nUDIX hydrolase
TBIS_RS15160	COG1388	LysM domain
TBIS_RS15160	COG0791	NLP P60 protein
TBIS_RS15205	COG0012	GTP binding
TBIS_RS15210	COG1322	Protein conserved in bacteria
TBIS_RS15220	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
TBIS_RS15230	COG1570	exodeoxyribonuclease VII activity
TBIS_RS15235	COG0367	asparagine synthase
TBIS_RS15240	COG1722	exodeoxyribonuclease VII activity
TBIS_RS15270	COG3962	Belongs to the TPP enzyme family
TBIS_RS15275	COG3718	enzyme involved in inositol metabolism
TBIS_RS15285	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
TBIS_RS15295	COG0673	inositol 2-dehydrogenase activity
TBIS_RS15315	COG0114	fumarate hydratase activity
TBIS_RS15325	COG1215	transferase activity, transferring glycosyl groups
TBIS_RS15335	COG0745	RESPONSE REGULATOR receiver
TBIS_RS15340	COG2205	protein histidine kinase activity
TBIS_RS15350	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
TBIS_RS15355	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
TBIS_RS15360	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
TBIS_RS15370	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
TBIS_RS15380	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
TBIS_RS15420	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
TBIS_RS15430	COG3185	4-Hydroxyphenylpyruvate dioxygenase
TBIS_RS15445	COG0180	Tryptophanyl-tRNA synthetase
TBIS_RS15450	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
TBIS_RS15460	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
TBIS_RS15485	COG2755	lipolytic protein G-D-S-L family
TBIS_RS15495	COG0183	Belongs to the thiolase family
TBIS_RS15515	COG2205	protein histidine kinase activity
TBIS_RS15520	COG0477	Major facilitator Superfamily
TBIS_RS15555	COG0148	phosphopyruvate hydratase activity
TBIS_RS15580	COG0529	Catalyzes the synthesis of activated sulfate
TBIS_RS15615	COG2815	serine threonine protein kinase
TBIS_RS15615	COG0515	serine threonine protein kinase
TBIS_RS15655	COG1218	3'(2'),5'-bisphosphate nucleotidase
TBIS_RS15660	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
TBIS_RS15665	COG0193	aminoacyl-tRNA hydrolase activity
TBIS_RS15670	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
TBIS_RS15675	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
TBIS_RS15680	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
TBIS_RS15695	COG1309	transcriptional regulator
TBIS_RS15700	COG4106	trans-aconitate 2-methyltransferase activity
TBIS_RS15715	COG0488	(ABC) transporter
TBIS_RS15735	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
TBIS_RS15740	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
TBIS_RS15745	COG0084	hydrolase, TatD family'
TBIS_RS15755	COG2132	Multicopper oxidase
TBIS_RS15765	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TBIS_RS15825	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
TBIS_RS15830	COG0521	Mo-molybdopterin cofactor biosynthetic process
TBIS_RS15835	COG0315	cyclic pyranopterin monophosphate synthase activity
TBIS_RS15845	COG1210	Utp--glucose-1-phosphate uridylyltransferase
TBIS_RS15850	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
TBIS_RS15855	COG3263	regulation of cellular component size
TBIS_RS15865	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
TBIS_RS15900	COG1252	NADH dehydrogenase
TBIS_RS15905	COG1595	DNA-templated transcription, initiation
TBIS_RS15910	COG1309	transcriptional regulator
TBIS_RS15915	COG1131	(ABC) transporter
TBIS_RS15920	COG3559	Exporter of polyketide antibiotics
TBIS_RS15925	COG1960	acyl-CoA dehydrogenase activity
TBIS_RS15930	COG0477	Major facilitator Superfamily
TBIS_RS15940	COG1960	acyl-CoA dehydrogenase activity
TBIS_RS15945	COG1024	Enoyl-CoA hydratase
TBIS_RS15950	COG0154	amidase activity
TBIS_RS15960	COG2267	carboxylic ester hydrolase activity
TBIS_RS15965	COG0318	PFAM AMP-dependent synthetase and ligase
TBIS_RS16000	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
TBIS_RS16005	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
TBIS_RS16010	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
TBIS_RS16015	COG0375	protein maturation
TBIS_RS16040	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
TBIS_RS16085	COG0309	Hydrogenase expression formation protein (HypE)
TBIS_RS16090	COG0298	carbon dioxide binding
TBIS_RS16095	COG0409	Hydrogenase expression formation protein
TBIS_RS16110	COG1063	alcohol dehydrogenase
TBIS_RS16125	COG0247	lactate metabolic process
TBIS_RS16130	COG1139	Iron-sulfur cluster binding protein
TBIS_RS16135	COG1556	Lactate utilization protein
TBIS_RS16155	COG0395	ABC-type sugar transport system, permease component
TBIS_RS16160	COG1175	transmembrane transport
TBIS_RS16210	COG0477	Major facilitator Superfamily
TBIS_RS16215	COG0662	Cupin 2, conserved barrel domain protein
TBIS_RS16230	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
TBIS_RS16240	COG0745	RESPONSE REGULATOR receiver
TBIS_RS16250	COG1136	(ABC) transporter
TBIS_RS16250	COG0577	efflux transmembrane transporter activity
TBIS_RS16255	COG1136	(ABC) transporter
TBIS_RS16280	COG2205	protein histidine kinase activity
TBIS_RS16285	COG0745	RESPONSE REGULATOR receiver
TBIS_RS16290	COG0579	oxidoreductase
TBIS_RS16310	COG1695	Transcriptional regulator
TBIS_RS16325	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
TBIS_RS16335	COG0667	Aldo Keto reductase
TBIS_RS16355	COG2252	PERMEase
TBIS_RS16375	COG1278	Cold shock
TBIS_RS16385	COG1061	Type III restriction enzyme res subunit
TBIS_RS16390	COG3973	AAA domain
TBIS_RS16395	COG0459	protein refolding
TBIS_RS16405	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
TBIS_RS16435	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
TBIS_RS16440	COG4608	Belongs to the ABC transporter superfamily
TBIS_RS16450	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TBIS_RS16455	COG0601	transmembrane transport
TBIS_RS16470	COG1134	teichoic acid transport
TBIS_RS16475	COG1881	PFAM PEBP family protein
TBIS_RS16490	COG0416	fatty acid biosynthetic process
TBIS_RS16495	COG0018	arginyl-trna synthetase
TBIS_RS16505	COG1799	cell septum assembly
TBIS_RS16535	COG0243	molybdopterin cofactor binding
TBIS_RS16550	COG1960	acyl-CoA dehydrogenase activity
TBIS_RS16565	COG0508	dehydrogenase complex catalyzes the overall conversion of
TBIS_RS16570	COG0022	dehydrogenase e1 component
TBIS_RS16585	COG0477	Major facilitator Superfamily
TBIS_RS16595	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
TBIS_RS16605	COG0047	phosphoribosylformylglycinamidine synthase activity
TBIS_RS16610	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
TBIS_RS16635	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
TBIS_RS16665	COG1309	transcriptional regulator
TBIS_RS16680	COG0860	N-Acetylmuramoyl-L-alanine amidase
TBIS_RS16685	COG3525	Glycosyl hydrolase, family 20, catalytic domain
TBIS_RS16710	COG0167	dihydroorotate dehydrogenase activity
TBIS_RS16765	COG1960	acyl-CoA dehydrogenase activity
TBIS_RS16780	COG0730	response to heat
TBIS_RS16785	COG1797	cobyrinic acid a,c-diamide synthase activity
TBIS_RS16795	COG2205	protein histidine kinase activity
TBIS_RS16800	COG3189	MarR family transcriptional regulator
TBIS_RS16830	COG1302	Protein conserved in bacteria
TBIS_RS16885	COG2197	response regulator
TBIS_RS16900	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
TBIS_RS16915	COG2188	Transcriptional regulator
TBIS_RS16950	COG1937	Protein conserved in bacteria
TBIS_RS16955	COG0438	transferase activity, transferring glycosyl groups
TBIS_RS16965	COG0247	lactate metabolic process
TBIS_RS16965	COG2181	nitrate reductase activity
TBIS_RS16970	COG1309	transcriptional regulator
TBIS_RS16975	COG2226	methyltransferase
TBIS_RS16980	COG1082	Xylose isomerase domain protein TIM barrel
TBIS_RS16985	COG2226	methyltransferase
TBIS_RS16990	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
TBIS_RS17000	COG1194	a g-specific adenine glycosylase
TBIS_RS17030	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
TBIS_RS17045	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
TBIS_RS17050	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
TBIS_RS17055	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
TBIS_RS17060	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
TBIS_RS17065	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
TBIS_RS17080	COG1690	Belongs to the RtcB family
TBIS_RS17085	COG1131	(ABC) transporter
TBIS_RS17110	COG1131	(ABC) transporter
TBIS_RS17125	COG2124	cytochrome p450
TBIS_RS17130	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
TBIS_RS17135	COG0649	NAD binding
TBIS_RS17145	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
TBIS_RS17150	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
TBIS_RS17160	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
TBIS_RS17165	COG0302	gtp cyclohydrolase
TBIS_RS17180	COG0037	tRNA processing
TBIS_RS17190	COG2027	D-alanyl-D-alanine carboxypeptidase
TBIS_RS17195	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
TBIS_RS17200	COG3883	PFAM NLP P60 protein
TBIS_RS17200	COG0791	NLP P60 protein
TBIS_RS17210	COG3268	Saccharopine dehydrogenase
TBIS_RS17230	COG0076	glutamate decarboxylase activity
TBIS_RS17235	COG3486	L-lysine 6-monooxygenase (NADPH) activity
TBIS_RS17265	COG1774	PSP1 C-terminal conserved region
TBIS_RS17270	COG0470	DNA polymerase III
TBIS_RS17275	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
TBIS_RS17280	COG1408	metallophosphoesterase
TBIS_RS17285	COG1754	DNA topoisomerase type I activity
TBIS_RS17285	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
TBIS_RS17305	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
TBIS_RS17345	COG1131	(ABC) transporter
TBIS_RS17420	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
TBIS_RS17430	COG1120	ATPase activity
TBIS_RS17435	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TBIS_RS17460	COG2815	serine threonine protein kinase
TBIS_RS17460	COG0515	serine threonine protein kinase
TBIS_RS17480	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
TBIS_RS17500	COG1482	cell wall glycoprotein biosynthetic process
TBIS_RS17510	COG1609	Transcriptional regulator
TBIS_RS17555	COG2890	protein-(glutamine-N5) methyltransferase activity
TBIS_RS17560	COG1309	transcriptional regulator
TBIS_RS17580	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
TBIS_RS17600	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
TBIS_RS17605	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
TBIS_RS17640	COG0590	tRNA wobble adenosine to inosine editing
TBIS_RS17655	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
TBIS_RS17675	COG2186	Transcriptional regulator
TBIS_RS17680	COG0592	DNA-directed DNA polymerase activity
TBIS_RS17685	COG2197	response regulator
TBIS_RS17695	COG1131	(ABC) transporter
TBIS_RS17710	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
TBIS_RS17715	COG1733	regulation of RNA biosynthetic process
TBIS_RS17720	COG0305	Participates in initiation and elongation during chromosome replication
TBIS_RS17725	COG0534	Mate efflux family protein
TBIS_RS17735	COG0765	amino acid transport
TBIS_RS17740	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
TBIS_RS17745	COG0359	binds to the 23S rRNA
TBIS_RS17750	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
TBIS_RS17760	COG0360	Binds together with S18 to 16S ribosomal RNA
TBIS_RS17785	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
TBIS_RS17800	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
TBIS_RS17810	COG0617	tRNA 3'-terminal CCA addition
TBIS_RS17830	COG0515	serine threonine protein kinase
TBIS_RS17830	COG2815	serine threonine protein kinase
TBIS_RS17835	COG1595	DNA-templated transcription, initiation
TBIS_RS17845	COG0492	ferredoxin-NADP+ reductase activity
TBIS_RS17850	COG3118	belongs to the thioredoxin family
TBIS_RS17860	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
TBIS_RS17865	COG1181	Belongs to the D-alanine--D-alanine ligase family
TBIS_RS17875	COG1695	Transcriptional regulator
TBIS_RS17895	COG1192	Involved in chromosome partitioning
TBIS_RS17900	COG0357	Ribosomal RNA small subunit methyltransferase G
TBIS_RS17910	COG0706	membrane insertase activity
TBIS_RS17920	COG0230	Belongs to the bacterial ribosomal protein bL34 family
TBIS_RS17975	COG0515	serine threonine protein kinase
TBIS_RS17985	COG1525	nuclease
TBIS_RS18005	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
TBIS_RS18025	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
TBIS_RS18040	COG3594	Acyltransferase
TBIS_RS18050	COG4585	Histidine kinase
TBIS_RS18100	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
TBIS_RS18135	COG1309	transcriptional regulator
TBIS_RS18140	COG3290	protein histidine kinase activity
TBIS_RS18145	COG3290	protein histidine kinase activity
TBIS_RS18210	COG0515	serine threonine protein kinase
TBIS_RS18210	COG2815	serine threonine protein kinase
TBIS_RS18240	COG0515	serine threonine protein kinase
TBIS_RS18255	COG0582	viral genome integration into host DNA
TBIS_RS18270	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
TBIS_RS18270	COG0515	serine threonine protein kinase
TBIS_RS18280	COG0515	serine threonine protein kinase
TBIS_RS18290	COG0515	serine threonine protein kinase
TBIS_RS18295	COG0515	serine threonine protein kinase
TBIS_RS18320	COG1028	Short-chain dehydrogenase reductase Sdr
TBIS_RS18375	COG0515	serine threonine protein kinase
TBIS_RS18375	COG2815	serine threonine protein kinase