locus-tag	class	description
A3L04_RS00005	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A3L04_RS00010	COG0601	transmembrane transport
A3L04_RS00020	COG2723	6-phospho-beta-galactosidase activity
A3L04_RS00060	COG1028	Short-chain dehydrogenase reductase Sdr
A3L04_RS00075	COG1378	Sugar-specific transcriptional regulator TrmB
A3L04_RS00080	COG1131	(ABC) transporter
A3L04_RS00090	COG0842	Transport permease protein
A3L04_RS00105	COG1141	Ferredoxin
A3L04_RS00115	COG0543	2 iron, 2 sulfur cluster binding
A3L04_RS00120	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
A3L04_RS00140	COG0463	Glycosyl transferase, family 2
A3L04_RS00160	COG0560	Phosphoserine phosphatase
A3L04_RS00165	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
A3L04_RS00240	COG1131	(ABC) transporter
A3L04_RS00245	COG0556	nucleotide-excision repair
A3L04_RS00250	COG0483	inositol monophosphate 1-phosphatase activity
A3L04_RS00260	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
A3L04_RS00290	COG0446	pyridine nucleotide-disulphide oxidoreductase
A3L04_RS00295	COG0579	oxidoreductase
A3L04_RS00315	COG0584	glycerophosphoryl diester phosphodiesterase
A3L04_RS00320	COG2211	Major facilitator Superfamily
A3L04_RS00350	COG1131	(ABC) transporter
A3L04_RS00365	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
A3L04_RS00385	COG0717	Belongs to the dCTP deaminase family
A3L04_RS00405	COG0081	regulation of translation
A3L04_RS00410	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
A3L04_RS00425	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
A3L04_RS00470	COG2078	PFAM AMMECR1 domain protein
A3L04_RS00495	COG0157	Belongs to the NadC ModD family
A3L04_RS00505	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
A3L04_RS00515	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
A3L04_RS00520	COG1892	Catalyzes the irreversible beta-carboxylation of phosphoenolpyruvate (PEP) to form oxaloacetate (OAA), a four- carbon dicarboxylic acid source for the tricarboxylic acid cycle
A3L04_RS00545	COG3842	ATPase activity
A3L04_RS00550	COG0581	inorganic phosphate transmembrane transporter activity
A3L04_RS00585	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
A3L04_RS00595	COG0730	response to heat
A3L04_RS00600	COG2414	aldehyde ferredoxin oxidoreductase
A3L04_RS00630	COG0667	Aldo Keto reductase
A3L04_RS00645	COG0746	molybdenum cofactor guanylyltransferase activity
A3L04_RS00670	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
A3L04_RS00700	COG1522	sequence-specific DNA binding
A3L04_RS00715	COG2234	aminopeptidase activity
A3L04_RS00735	COG0307	riboflavin synthase, alpha
A3L04_RS00740	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
A3L04_RS00740	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
A3L04_RS00790	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
A3L04_RS00795	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
A3L04_RS00795	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
A3L04_RS00820	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
A3L04_RS00830	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
A3L04_RS00855	COG1694	Mazg nucleotide pyrophosphohydrolase
A3L04_RS00885	COG0252	asparaginase activity
A3L04_RS00900	COG0297	glycogen (starch) synthase activity
A3L04_RS00910	COG1628	Protein of unknown function DUF99
A3L04_RS00955	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
A3L04_RS00955	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
A3L04_RS00965	COG2403	cyclic 2,3-diphosphoglycerate synthetase activity
A3L04_RS00970	COG0725	ABC transporter, periplasmic molybdate-binding protein
A3L04_RS00980	COG4149	molybdate abc transporter
A3L04_RS00985	COG1106	Psort location Cytoplasmic, score
A3L04_RS00995	COG3842	ATPase activity
A3L04_RS01000	COG1268	BioY protein
A3L04_RS01020	COG1353	crispr-associated protein
A3L04_RS01030	COG1337	RAMP superfamily
A3L04_RS01070	COG1518	maintenance of DNA repeat elements
A3L04_RS01075	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
A3L04_RS01085	COG1203	CRISPR-associated helicase, Cas3
A3L04_RS01100	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
A3L04_RS01120	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
A3L04_RS01145	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
A3L04_RS01155	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A3L04_RS01195	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
A3L04_RS01195	COG0574	Belongs to the PEP-utilizing enzyme family
A3L04_RS01215	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
A3L04_RS01235	COG0010	Belongs to the arginase family
A3L04_RS01240	COG1830	Aldolase
A3L04_RS01255	COG1605	Chorismate mutase
A3L04_RS01255	COG0077	Prephenate dehydratase
A3L04_RS01280	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
A3L04_RS01280	COG0517	IMP dehydrogenase activity
A3L04_RS01285	COG0175	sulfate reduction
A3L04_RS01295	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
A3L04_RS01305	COG0346	lactoylglutathione lyase activity
A3L04_RS01315	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
A3L04_RS01315	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
A3L04_RS01365	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
A3L04_RS01370	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
A3L04_RS01400	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
A3L04_RS01415	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A3L04_RS01415	COG0301	tRNA thio-modification
A3L04_RS01430	COG1122	ATPase activity
A3L04_RS01450	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
A3L04_RS01475	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
A3L04_RS01495	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
A3L04_RS01530	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
A3L04_RS01575	COG2255	four-way junction helicase activity
A3L04_RS01580	COG2255	four-way junction helicase activity
A3L04_RS01620	COG0314	molybdopterin synthase activity
A3L04_RS01630	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
A3L04_RS01635	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
A3L04_RS01655	COG0235	Class ii aldolase
A3L04_RS01680	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
A3L04_RS01685	COG0218	Necessary for normal cell division and for the maintenance of normal septation
A3L04_RS01695	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
A3L04_RS01700	COG3842	ATPase activity
A3L04_RS01705	COG0395	ABC-type sugar transport system, permease component
A3L04_RS01720	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A3L04_RS01725	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
A3L04_RS01735	COG1378	Sugar-specific transcriptional regulator TrmB
A3L04_RS01745	COG0556	nucleotide-excision repair
A3L04_RS01750	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
A3L04_RS01805	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
A3L04_RS01815	COG2226	methyltransferase
A3L04_RS01890	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
A3L04_RS01895	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
A3L04_RS01910	COG0017	Asparaginyl-tRNA synthetase
A3L04_RS01925	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
A3L04_RS01940	COG0312	modulator of DNA gyrase
A3L04_RS01960	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
A3L04_RS01975	COG0750	zinc metalloprotease
A3L04_RS01985	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
A3L04_RS01985	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
A3L04_RS02000	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
A3L04_RS02010	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
A3L04_RS02025	COG1269	ATP hydrolysis coupled proton transport
A3L04_RS02035	COG1390	Produces ATP from ADP in the presence of a proton gradient across the membrane
A3L04_RS02050	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
A3L04_RS02055	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
A3L04_RS02060	COG1394	ATPase activity, coupled to movement of substances
A3L04_RS02065	COG0426	domain, Protein
A3L04_RS02065	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
A3L04_RS02075	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
A3L04_RS02080	COG0482	sulfurtransferase activity
A3L04_RS02090	COG0543	2 iron, 2 sulfur cluster binding
A3L04_RS02095	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
A3L04_RS02105	COG0601	transmembrane transport
A3L04_RS02110	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A3L04_RS02115	COG0444	Belongs to the ABC transporter superfamily
A3L04_RS02120	COG4608	Belongs to the ABC transporter superfamily
A3L04_RS02130	COG2140	Oxalate decarboxylase
A3L04_RS02140	COG0047	phosphoribosylformylglycinamidine synthase activity
A3L04_RS02150	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
A3L04_RS02155	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
A3L04_RS02160	COG2151	metal-sulfur cluster biosynthetic enzyme
A3L04_RS02175	COG0165	Argininosuccinate lyase
A3L04_RS02180	COG0189	ligase activity
A3L04_RS02205	COG0417	DNA replication proofreading
A3L04_RS02210	COG1234	tRNA 3'-trailer cleavage
A3L04_RS02220	COG0148	phosphopyruvate hydratase activity
A3L04_RS02225	COG0424	maF-like protein
A3L04_RS02240	COG0720	synthase
A3L04_RS02245	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
A3L04_RS02255	COG1011	Hydrolase
A3L04_RS02270	COG1418	mRNA catabolic process
A3L04_RS02285	COG0640	Transcriptional regulator
A3L04_RS02310	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
A3L04_RS02350	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
A3L04_RS02355	COG1522	sequence-specific DNA binding
A3L04_RS02360	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
A3L04_RS02400	COG0539	negative regulation of cytoplasmic translation
A3L04_RS02405	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
A3L04_RS02415	COG0011	TIGRFAM Protein of
A3L04_RS02430	COG2409	Drug exporters of the RND superfamily
A3L04_RS02460	COG0156	8-amino-7-oxononanoate synthase activity
A3L04_RS02485	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
A3L04_RS02505	COG1449	Belongs to the glycosyl hydrolase 57 family
A3L04_RS02520	COG1215	transferase activity, transferring glycosyl groups
A3L04_RS02530	COG0037	tRNA processing
A3L04_RS02535	COG0475	glutathione-regulated potassium exporter activity
A3L04_RS02540	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
A3L04_RS02555	COG1254	Belongs to the acylphosphatase family
A3L04_RS02565	COG0517	IMP dehydrogenase activity
A3L04_RS02565	COG0516	GMP reductase activity
A3L04_RS02595	COG0067	glutamate synthase
A3L04_RS02600	COG0372	Belongs to the citrate synthase family
A3L04_RS02605	COG0538	isocitrate dehydrogenase activity
A3L04_RS02610	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
A3L04_RS02615	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
A3L04_RS02615	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
A3L04_RS02620	COG0438	transferase activity, transferring glycosyl groups
A3L04_RS02630	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
A3L04_RS02635	COG1210	Utp--glucose-1-phosphate uridylyltransferase
A3L04_RS02695	COG1215	transferase activity, transferring glycosyl groups
A3L04_RS02700	COG0438	transferase activity, transferring glycosyl groups
A3L04_RS02705	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
A3L04_RS02705	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
A3L04_RS02725	COG0438	transferase activity, transferring glycosyl groups
A3L04_RS02730	COG0463	Glycosyl transferase, family 2
A3L04_RS02740	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A3L04_RS02740	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A3L04_RS02875	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
A3L04_RS02880	COG2201	protein-glutamate methylesterase activity
A3L04_RS02885	COG2201	protein-glutamate methylesterase activity
A3L04_RS02890	COG0643	Histidine kinase
A3L04_RS02890	COG2198	Histidine kinase
A3L04_RS02895	COG1776	CheC inhibitor of MCP methylation
A3L04_RS02905	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
A3L04_RS02910	COG0840	transmembrane signaling receptor activity
A3L04_RS02930	COG2379	hydroxypyruvate reductase
A3L04_RS02955	COG2723	6-phospho-beta-galactosidase activity
A3L04_RS02965	COG0601	transmembrane transport
A3L04_RS02975	COG4608	Belongs to the ABC transporter superfamily
A3L04_RS02980	COG4608	Belongs to the ABC transporter superfamily
A3L04_RS02985	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
A3L04_RS03005	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A3L04_RS03010	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
A3L04_RS03070	COG1131	(ABC) transporter
A3L04_RS03085	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A3L04_RS03090	COG0071	Belongs to the small heat shock protein (HSP20) family
A3L04_RS03095	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
A3L04_RS03110	COG1458	PINc domain ribonuclease
A3L04_RS03125	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
A3L04_RS03160	COG1867	N(2),N(2)-dimethylguanosine tRNA methyltransferase
A3L04_RS03185	COG1812	S-adenosylmethionine synthetase (AdoMet synthetase)
A3L04_RS03195	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
A3L04_RS03220	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
A3L04_RS03225	COG1122	ATPase activity
A3L04_RS03230	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
A3L04_RS03240	COG0315	cyclic pyranopterin monophosphate synthase activity
A3L04_RS03250	COG1028	Short-chain dehydrogenase reductase Sdr
A3L04_RS03255	COG0493	'glutamate synthase
A3L04_RS03265	COG0534	Mate efflux family protein
A3L04_RS03270	COG2894	cell division
A3L04_RS03285	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
A3L04_RS03300	COG1346	cytolysis
A3L04_RS03310	COG1196	nuclear chromosome segregation
A3L04_RS03345	COG0504	CTP synthase activity
A3L04_RS03355	COG0045	succinate-CoA ligase (ADP-forming) activity
A3L04_RS03355	COG1042	CoA-binding domain protein
A3L04_RS03355	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A3L04_RS03380	COG1469	GTP cyclohydrolase I activity
A3L04_RS03395	COG1078	dGTPase activity
A3L04_RS03405	COG0517	IMP dehydrogenase activity
A3L04_RS03405	COG0516	GMP reductase activity
A3L04_RS03415	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
A3L04_RS03420	COG0088	Forms part of the polypeptide exit tunnel
A3L04_RS03425	COG0089	rRNA binding
A3L04_RS03430	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
A3L04_RS03435	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
A3L04_RS03445	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
A3L04_RS03450	COG0255	Belongs to the universal ribosomal protein uL29 family
A3L04_RS03470	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
A3L04_RS03485	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
A3L04_RS03495	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
A3L04_RS03500	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
A3L04_RS03515	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
A3L04_RS03520	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
A3L04_RS03530	COG0200	Binds to the 23S rRNA
A3L04_RS03550	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A3L04_RS03570	COG1476	TRANSCRIPTIONal
A3L04_RS03600	COG0546	phosphoglycolate phosphatase activity
A3L04_RS03605	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A3L04_RS03660	COG0501	Belongs to the peptidase M48B family
A3L04_RS03680	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
A3L04_RS03685	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
A3L04_RS03710	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
A3L04_RS03715	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
A3L04_RS03720	COG0107	imidazoleglycerol-phosphate synthase activity
A3L04_RS03725	COG0140	phosphoribosyl-ATP diphosphatase activity
A3L04_RS03725	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
A3L04_RS03730	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
A3L04_RS03765	COG0697	spore germination
A3L04_RS03775	COG2890	protein-(glutamine-N5) methyltransferase activity
A3L04_RS03805	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A3L04_RS03810	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
A3L04_RS03815	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
A3L04_RS03820	COG0066	3-isopropylmalate dehydratase activity
A3L04_RS03825	COG0473	3-isopropylmalate dehydrogenase activity
A3L04_RS03835	COG0189	ligase activity
A3L04_RS03840	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
A3L04_RS03845	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
A3L04_RS03850	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
A3L04_RS03855	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A3L04_RS03865	COG3959	Transketolase, thiamine diphosphate binding domain
A3L04_RS03870	COG3958	Transketolase
A3L04_RS03875	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
A3L04_RS03880	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
A3L04_RS03885	COG0710	3-dehydroquinate dehydratase activity
A3L04_RS03890	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
A3L04_RS03895	COG0083	homoserine kinase activity
A3L04_RS03900	COG1744	ABC transporter substrate-binding protein PnrA-like
A3L04_RS03905	COG3845	ABC transporter
A3L04_RS03910	COG4603	Belongs to the binding-protein-dependent transport system permease family
A3L04_RS03915	COG1079	Belongs to the binding-protein-dependent transport system permease family
A3L04_RS03920	COG1063	alcohol dehydrogenase
A3L04_RS03945	COG0287	Prephenate dehydrogenase
A3L04_RS03945	COG1605	Chorismate mutase
A3L04_RS03950	COG0436	Aminotransferase
A3L04_RS03960	COG0159	tryptophan synthase activity
A3L04_RS03965	COG0133	tryptophan synthase activity
A3L04_RS03970	COG0135	phosphoribosylanthranilate isomerase activity
A3L04_RS03975	COG0512	Glutamine amidotransferase of anthranilate synthase
A3L04_RS03975	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
A3L04_RS03980	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
A3L04_RS03985	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
A3L04_RS04000	COG0505	Belongs to the CarA family
A3L04_RS04010	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
A3L04_RS04030	COG0693	protein deglycase activity
A3L04_RS04050	COG1032	radical SAM domain protein
A3L04_RS04065	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
A3L04_RS04075	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
A3L04_RS04080	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
A3L04_RS04095	COG1522	sequence-specific DNA binding
A3L04_RS04120	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
A3L04_RS04120	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
A3L04_RS04130	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
A3L04_RS04165	COG0300	oxidoreductase activity
A3L04_RS04180	COG0393	Putative heavy-metal-binding
A3L04_RS04200	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
A3L04_RS04210	COG0037	tRNA processing
A3L04_RS04240	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
A3L04_RS04245	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
A3L04_RS04250	COG1872	DUF167
A3L04_RS04255	COG0552	protein localization to endoplasmic reticulum
A3L04_RS04255	COG0457	Tetratricopeptide repeat
A3L04_RS04265	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
A3L04_RS04265	COG0674	pyruvate-flavodoxin oxidoreductase activity
A3L04_RS04270	COG1013	pyruvate-flavodoxin oxidoreductase activity
A3L04_RS04280	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
A3L04_RS04280	COG0674	pyruvate-flavodoxin oxidoreductase activity
A3L04_RS04285	COG1013	pyruvate-flavodoxin oxidoreductase activity
A3L04_RS04295	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
A3L04_RS04310	COG1011	Hydrolase
A3L04_RS04315	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
A3L04_RS04350	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
A3L04_RS04370	COG2813	Specifically methylates the guanine in position
A3L04_RS04380	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
A3L04_RS04385	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
A3L04_RS04415	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
A3L04_RS04435	COG0148	phosphopyruvate hydratase activity
A3L04_RS04440	COG0052	Belongs to the universal ribosomal protein uS2 family
A3L04_RS04445	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
A3L04_RS04450	COG1355	regulation of microtubule-based process
A3L04_RS04455	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
A3L04_RS04490	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
A3L04_RS04515	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
A3L04_RS04520	COG0423	glycine-tRNA ligase activity
A3L04_RS04540	COG0482	sulfurtransferase activity
A3L04_RS04545	COG1234	tRNA 3'-trailer cleavage
A3L04_RS04580	COG2894	cell division
A3L04_RS04590	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
A3L04_RS04595	COG1216	Glycosyl transferase, family 2
A3L04_RS04610	COG0475	glutathione-regulated potassium exporter activity
A3L04_RS04615	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
A3L04_RS04620	COG1522	sequence-specific DNA binding
A3L04_RS04630	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
A3L04_RS04635	COG2131	deaminase
A3L04_RS04665	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
A3L04_RS04680	COG0489	protein tyrosine kinase activity
A3L04_RS04710	COG0628	permease
A3L04_RS04720	COG0616	signal peptide processing
A3L04_RS04740	COG2205	protein histidine kinase activity
A3L04_RS04770	COG0312	modulator of DNA gyrase
A3L04_RS04790	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
A3L04_RS04805	COG1185	polyribonucleotide nucleotidyltransferase activity
A3L04_RS04810	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
A3L04_RS04840	COG0085	RNA polymerase activity
A3L04_RS04845	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
A3L04_RS04850	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
A3L04_RS04870	COG0049	tRNA binding
A3L04_RS04885	COG0585	pseudouridine synthase activity
A3L04_RS04895	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
A3L04_RS04895	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
A3L04_RS04940	COG0778	Nitroreductase
A3L04_RS04970	COG1476	TRANSCRIPTIONal
A3L04_RS04980	COG1131	(ABC) transporter
A3L04_RS04995	COG0430	RNA-3'-phosphate cyclase activity
A3L04_RS05035	COG1522	sequence-specific DNA binding
A3L04_RS05055	COG0167	dihydroorotate dehydrogenase activity
A3L04_RS05060	COG0402	S-adenosylhomocysteine deaminase activity
A3L04_RS05070	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
A3L04_RS05070	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
A3L04_RS05075	COG0058	SHG alpha-glucan phosphorylase activity
A3L04_RS05080	COG0330	HflC and HflK could
A3L04_RS05090	COG0446	pyridine nucleotide-disulphide oxidoreductase
A3L04_RS05095	COG2033	superoxide reductase activity
A3L04_RS05100	COG1773	rubredoxin
A3L04_RS05110	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
A3L04_RS05125	COG0426	domain, Protein
A3L04_RS05130	COG4221	oxidoreductase activity
A3L04_RS05140	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
A3L04_RS05145	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
A3L04_RS05200	COG2971	BadF BadG BcrA BcrD
A3L04_RS05210	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A3L04_RS05215	COG0601	transmembrane transport
A3L04_RS05250	COG4821	SIS domain
A3L04_RS05300	COG0543	2 iron, 2 sulfur cluster binding
A3L04_RS05305	COG0493	'glutamate synthase
A3L04_RS05305	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
A3L04_RS05335	COG0450	alkyl hydroperoxide reductase
A3L04_RS05355	COG1131	(ABC) transporter
A3L04_RS05365	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A3L04_RS05375	COG1525	nuclease
A3L04_RS05385	COG1373	ATPase (AAA superfamily
A3L04_RS05405	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
A3L04_RS05425	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A3L04_RS05445	COG0442	prolyl-tRNA aminoacylation
A3L04_RS05460	COG1111	helicase
A3L04_RS05460	COG1205	dead DEAH box helicase
A3L04_RS05485	COG1335	isochorismatase
A3L04_RS05490	COG0527	aspartate kinase activity
A3L04_RS05490	COG0460	homoserine dehydrogenase
A3L04_RS05495	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
A3L04_RS05510	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
A3L04_RS05515	COG1230	cation diffusion facilitator family transporter
A3L04_RS05525	COG0428	transporter
A3L04_RS05635	COG1984	allophanate hydrolase subunit 2
A3L04_RS05640	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
A3L04_RS05645	COG1487	ribonuclease activity
A3L04_RS05655	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
A3L04_RS05660	COG1373	ATPase (AAA superfamily
A3L04_RS05680	COG1131	(ABC) transporter
A3L04_RS05710	COG1120	ATPase activity
A3L04_RS05715	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A3L04_RS05720	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
A3L04_RS05755	COG1131	(ABC) transporter
A3L04_RS05775	COG0101	tRNA pseudouridine synthase activity
A3L04_RS05785	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A3L04_RS05785	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A3L04_RS05795	COG1966	Carbon starvation protein
A3L04_RS05805	COG0003	Pfam Anion-transporting ATPase
A3L04_RS05820	COG0105	UTP biosynthetic process
A3L04_RS05830	COG1199	ATP-dependent helicase activity
A3L04_RS05840	COG0028	Belongs to the TPP enzyme family
A3L04_RS05845	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
A3L04_RS05850	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
A3L04_RS05855	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
A3L04_RS05860	COG0066	3-isopropylmalate dehydratase activity
A3L04_RS05865	COG0473	3-isopropylmalate dehydrogenase activity
A3L04_RS05870	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
A3L04_RS05875	COG0129	dihydroxy-acid dehydratase activity
A3L04_RS05910	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
A3L04_RS05920	COG1013	pyruvate-flavodoxin oxidoreductase activity
A3L04_RS05925	COG0674	pyruvate-flavodoxin oxidoreductase activity
A3L04_RS05935	COG1013	pyruvate-flavodoxin oxidoreductase activity
A3L04_RS05940	COG0674	pyruvate-flavodoxin oxidoreductase activity
A3L04_RS05955	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
A3L04_RS05980	COG2431	L-lysine efflux transmembrane transporter activity
A3L04_RS05990	COG2096	Adenosyltransferase
A3L04_RS06035	COG1515	deoxyribonuclease V activity
A3L04_RS06055	COG1063	alcohol dehydrogenase
A3L04_RS06090	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
A3L04_RS06105	COG0179	Fumarylacetoacetate (FAA) hydrolase
A3L04_RS06120	COG0306	phosphate transporter
A3L04_RS06125	COG1392	Phosphate transport regulator
A3L04_RS06135	COG0215	cysteine-tRNA ligase activity
A3L04_RS06170	COG0469	pyruvate kinase activity
A3L04_RS06180	COG0446	pyridine nucleotide-disulphide oxidoreductase
A3L04_RS06185	COG0534	Mate efflux family protein
A3L04_RS06190	COG0534	Mate efflux family protein
A3L04_RS06195	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
A3L04_RS06220	COG0432	Pfam Uncharacterised protein family UPF0047
A3L04_RS06230	COG0303	'Molybdopterin
A3L04_RS06245	COG0024	Methionine aminopeptidase
A3L04_RS06255	COG0489	protein tyrosine kinase activity
A3L04_RS06270	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
A3L04_RS06275	COG1863	multisubunit Na H antiporter MnhE subunit
A3L04_RS06280	COG2212	antiporter activity
A3L04_RS06285	COG1320	monovalent cation:proton antiporter activity
A3L04_RS06290	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
A3L04_RS06290	COG2111	Na H antiporter
A3L04_RS06305	COG0651	ATP synthesis coupled electron transport
A3L04_RS06315	COG1850	ribulose-bisphosphate carboxylase activity
A3L04_RS06330	COG0076	glutamate decarboxylase activity
A3L04_RS06350	COG4651	solute:proton antiporter activity
A3L04_RS06350	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
A3L04_RS06365	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
A3L04_RS06535	COG2050	protein possibly involved in aromatic compounds catabolism
A3L04_RS06535	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
A3L04_RS06545	COG2226	methyltransferase
A3L04_RS06555	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
A3L04_RS06560	COG0306	phosphate transporter
A3L04_RS06595	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A3L04_RS06600	COG0351	phosphomethylpyrimidine kinase
A3L04_RS06605	COG0352	thiamine-phosphate diphosphorylase activity
A3L04_RS06610	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
A3L04_RS06625	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
A3L04_RS06630	COG1881	PFAM PEBP family protein
A3L04_RS06655	COG0006	proline dipeptidase activity
A3L04_RS06665	COG1234	tRNA 3'-trailer cleavage
A3L04_RS06685	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
A3L04_RS06710	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
A3L04_RS06745	COG0563	adenylate kinase activity
A3L04_RS06775	COG1201	RNA secondary structure unwinding
A3L04_RS06785	COG1832	CoA-binding protein
A3L04_RS06800	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
A3L04_RS06810	COG0477	Major facilitator Superfamily
A3L04_RS06815	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
A3L04_RS06840	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
A3L04_RS06845	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
A3L04_RS06850	COG2414	aldehyde ferredoxin oxidoreductase
A3L04_RS06875	COG0123	including yeast histone deacetylase and acetoin utilization protein
A3L04_RS06885	COG1102	Psort location Cytoplasmic, score
A3L04_RS06900	COG1505	serine-type exopeptidase activity
A3L04_RS06910	COG2271	Major facilitator Superfamily
A3L04_RS06985	COG2226	methyltransferase
A3L04_RS06995	COG0719	Fe-S assembly protein
A3L04_RS07000	COG0396	ATPase activity
A3L04_RS07050	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
A3L04_RS07105	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A3L04_RS07125	COG0243	molybdopterin cofactor binding
A3L04_RS07130	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
A3L04_RS07150	COG1635	Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur
A3L04_RS07160	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
A3L04_RS07175	COG3383	formate dehydrogenase (NAD+) activity
A3L04_RS07185	COG4208	sulfate ABC transporter
A3L04_RS07190	COG3842	ATPase activity
A3L04_RS07195	COG4143	(ABC) transporter
A3L04_RS07210	COG0518	GMP synthase (glutamine-hydrolyzing) activity
A3L04_RS07210	COG0519	Catalyzes the synthesis of GMP from XMP
A3L04_RS07225	COG0518	GMP synthase (glutamine-hydrolyzing) activity
A3L04_RS07225	COG0519	Catalyzes the synthesis of GMP from XMP
A3L04_RS07275	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
A3L04_RS07290	COG1201	RNA secondary structure unwinding
A3L04_RS07365	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
A3L04_RS07380	COG0509	glycine decarboxylation via glycine cleavage system
A3L04_RS07390	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
A3L04_RS07405	COG0301	tRNA thio-modification
A3L04_RS07435	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
A3L04_RS07435	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
A3L04_RS07460	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
A3L04_RS07480	COG2002	toxin-antitoxin pair type II binding
A3L04_RS07490	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
A3L04_RS07500	COG0252	asparaginase activity
A3L04_RS07525	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
A3L04_RS07530	COG1863	multisubunit Na H antiporter MnhE subunit
A3L04_RS07535	COG2212	antiporter activity
A3L04_RS07550	COG2111	Na H antiporter
A3L04_RS07550	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
A3L04_RS07555	COG1006	Multisubunit Na H antiporter MnhC subunit
A3L04_RS07560	COG0651	ATP synthesis coupled electron transport
A3L04_RS07565	COG0651	ATP synthesis coupled electron transport
A3L04_RS07570	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
A3L04_RS07575	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A3L04_RS07585	COG0649	NAD binding
A3L04_RS07620	COG0650	Formate hydrogenlyase subunit 4
A3L04_RS07630	COG3261	NADH dehydrogenase
A3L04_RS07630	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
A3L04_RS07635	COG3260	NADH ubiquinone oxidoreductase 20
A3L04_RS07645	COG0651	ATP synthesis coupled electron transport
A3L04_RS07650	COG1006	Multisubunit Na H antiporter MnhC subunit
A3L04_RS07670	COG1320	monovalent cation:proton antiporter activity
A3L04_RS07675	COG2212	antiporter activity
A3L04_RS07680	COG1863	multisubunit Na H antiporter MnhE subunit
A3L04_RS07685	COG0492	ferredoxin-NADP+ reductase activity
A3L04_RS07690	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
A3L04_RS07695	COG0561	phosphatase activity
A3L04_RS07715	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
A3L04_RS07730	COG4608	Belongs to the ABC transporter superfamily
A3L04_RS07735	COG0444	Belongs to the ABC transporter superfamily
A3L04_RS07740	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A3L04_RS07745	COG0601	transmembrane transport
A3L04_RS07750	COG0747	negative chemotaxis
A3L04_RS07755	COG0528	UMP kinase activity
A3L04_RS07765	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
A3L04_RS07770	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
A3L04_RS07785	COG1047	Peptidyl-prolyl cis-trans
A3L04_RS07810	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
A3L04_RS07820	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
A3L04_RS07825	COG1543	Belongs to the glycosyl hydrolase 57 family
A3L04_RS07870	COG1573	uracil-dna glycosylase
A3L04_RS07900	COG0018	arginyl-trna synthetase
A3L04_RS07925	COG0051	transcription antitermination factor activity, RNA binding
A3L04_RS07930	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
A3L04_RS07935	COG0095	Lipoate-protein ligase
A3L04_RS07940	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
A3L04_RS07980	COG0457	Tetratricopeptide repeat
A3L04_RS07980	COG0705	Rhomboid family
A3L04_RS07990	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
A3L04_RS08000	COG1349	DNA-binding transcription factor activity
A3L04_RS08025	COG0489	protein tyrosine kinase activity
A3L04_RS08030	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
A3L04_RS08030	COG0731	radical SAM domain protein
A3L04_RS08055	COG1309	transcriptional regulator
A3L04_RS08060	COG0243	molybdopterin cofactor binding
A3L04_RS08070	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
A3L04_RS08075	COG0651	ATP synthesis coupled electron transport
A3L04_RS08080	COG0650	Formate hydrogenlyase subunit 4
A3L04_RS08085	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
A3L04_RS08085	COG3261	NADH dehydrogenase
A3L04_RS08090	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A3L04_RS08095	COG3260	NADH ubiquinone oxidoreductase 20
A3L04_RS08105	COG2212	antiporter activity
A3L04_RS08125	COG1006	Multisubunit Na H antiporter MnhC subunit
A3L04_RS08145	COG0746	molybdenum cofactor guanylyltransferase activity
A3L04_RS08155	COG1151	hydroxylamine reductase activity
A3L04_RS08185	COG1592	Rubrerythrin
A3L04_RS08215	COG1185	polyribonucleotide nucleotidyltransferase activity
A3L04_RS08245	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A3L04_RS08300	COG0312	modulator of DNA gyrase
A3L04_RS08305	COG0312	modulator of DNA gyrase
A3L04_RS08335	COG0367	asparagine synthase
A3L04_RS08350	COG1132	(ABC) transporter
A3L04_RS08355	COG1132	(ABC) transporter
A3L04_RS08370	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
A3L04_RS08375	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
A3L04_RS08400	COG0747	negative chemotaxis
A3L04_RS08405	COG0601	transmembrane transport
A3L04_RS08410	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A3L04_RS08415	COG0444	Belongs to the ABC transporter superfamily
A3L04_RS08420	COG4608	Belongs to the ABC transporter superfamily
A3L04_RS08440	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
A3L04_RS08440	COG1213	nucleotidyl transferase
A3L04_RS08455	COG0126	phosphoglycerate kinase activity
A3L04_RS08465	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
A3L04_RS08475	COG0083	homoserine kinase activity
A3L04_RS08480	COG0460	homoserine dehydrogenase
A3L04_RS08480	COG0527	aspartate kinase activity
A3L04_RS08485	COG0460	homoserine dehydrogenase
A3L04_RS08485	COG0527	aspartate kinase activity
A3L04_RS08500	COG0440	acetolactate synthase activity
A3L04_RS08550	COG1401	restriction endodeoxyribonuclease activity
A3L04_RS08555	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
A3L04_RS08615	COG0420	3'-5' exonuclease activity
A3L04_RS08620	COG0419	ATPase involved in DNA repair
A3L04_RS08625	COG0488	(ABC) transporter
A3L04_RS08640	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
A3L04_RS08640	COG0493	'glutamate synthase
A3L04_RS08645	COG0543	2 iron, 2 sulfur cluster binding
A3L04_RS08655	COG0543	2 iron, 2 sulfur cluster binding
A3L04_RS08685	COG0298	carbon dioxide binding
A3L04_RS08690	COG0409	Hydrogenase expression formation protein
A3L04_RS08695	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
A3L04_RS08700	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
A3L04_RS08715	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
A3L04_RS08740	COG0739	heme binding
A3L04_RS08775	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
A3L04_RS08790	COG0163	prenyltransferase activity
A3L04_RS08795	COG1522	sequence-specific DNA binding
A3L04_RS08820	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
A3L04_RS08825	COG0434	BtpA family
A3L04_RS08830	COG0084	hydrolase, TatD family'
A3L04_RS08840	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
A3L04_RS08840	COG1918	ferrous iron import across plasma membrane
A3L04_RS08855	COG1304	FMN binding
A3L04_RS08885	COG2252	PERMEase
A3L04_RS08890	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
A3L04_RS08905	COG1574	metal-dependent hydrolase with the TIM-barrel fold
A3L04_RS08915	COG2414	aldehyde ferredoxin oxidoreductase
A3L04_RS08925	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
A3L04_RS08930	COG0017	Asparaginyl-tRNA synthetase
A3L04_RS09025	COG1941	NADH ubiquinone oxidoreductase 20 kDa subunit
A3L04_RS09035	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
A3L04_RS09050	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
A3L04_RS09065	COG0626	cystathionine gamma-synthase activity
A3L04_RS09080	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
A3L04_RS09085	COG1518	maintenance of DNA repeat elements
A3L04_RS09095	COG1203	CRISPR-associated helicase, Cas3
A3L04_RS09155	COG2192	nodulation
A3L04_RS09165	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
A3L04_RS09165	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
A3L04_RS09175	COG0501	Belongs to the peptidase M48B family
A3L04_RS09180	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
A3L04_RS09185	COG1993	acr, cog1993
A3L04_RS09210	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
A3L04_RS09225	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A3L04_RS09230	COG1473	amidohydrolase
A3L04_RS09235	COG1522	sequence-specific DNA binding
A3L04_RS09265	COG1233	COG1233 Phytoene dehydrogenase and related
A3L04_RS09275	COG1342	Belongs to the UPF0251 family
A3L04_RS09295	COG2020	methyltransferase activity
A3L04_RS09315	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
A3L04_RS09315	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
A3L04_RS09320	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
A3L04_RS09355	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
A3L04_RS09360	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
A3L04_RS09365	COG0251	oxidation-reduction process
A3L04_RS09370	COG1129	ABC transporter
A3L04_RS09375	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
A3L04_RS09385	COG5016	pyruvate
A3L04_RS09385	COG0511	ligase activity, forming carbon-carbon bonds
A3L04_RS09390	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
A3L04_RS09395	COG0281	malic enzyme
A3L04_RS09465	COG0351	phosphomethylpyrimidine kinase
A3L04_RS09465	COG1992	Thiamine-phosphate synthase
A3L04_RS09480	COG0540	Belongs to the ATCase OTCase family
A3L04_RS09485	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
A3L04_RS09490	COG1473	amidohydrolase
A3L04_RS09515	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
A3L04_RS09535	COG0284	orotidine-5'-phosphate decarboxylase activity
A3L04_RS09545	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
A3L04_RS09545	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
A3L04_RS09560	COG1363	Peptidase, m42
A3L04_RS09585	COG0525	valine-tRNA ligase activity
A3L04_RS09600	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
A3L04_RS09620	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
A3L04_RS09625	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
A3L04_RS09630	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
A3L04_RS09670	COG0714	Associated with various cellular activities
A3L04_RS09700	COG0668	transmembrane transport
A3L04_RS09705	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
A3L04_RS09730	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
A3L04_RS09750	COG1160	GTP binding
A3L04_RS09815	COG2894	cell division
A3L04_RS09865	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
A3L04_RS09880	COG1110	DNA topoisomerase II activity
A3L04_RS09905	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
A3L04_RS09910	COG1618	nucleotide phosphatase activity, acting on free nucleotides
A3L04_RS09915	COG1120	ATPase activity
A3L04_RS09920	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A3L04_RS09925	COG1444	tRNA N-acetyltransferase activity
A3L04_RS09960	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
A3L04_RS09970	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
A3L04_RS09975	COG1115	amino acid carrier protein
A3L04_RS09990	COG0714	Associated with various cellular activities
A3L04_RS10010	COG2119	membrane
A3L04_RS10015	COG0436	Aminotransferase
A3L04_RS10030	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
A3L04_RS10035	COG1192	Involved in chromosome partitioning
A3L04_RS10050	COG1122	ATPase activity
A3L04_RS10065	COG0310	cobalt ion transport
A3L04_RS10110	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
A3L04_RS10120	COG2095	MarC family integral membrane protein
A3L04_RS10125	COG1980	fructose-bisphosphate aldolase activity
A3L04_RS10165	COG1695	Transcriptional regulator
A3L04_RS10180	COG1899	peptidyl-lysine modification to peptidyl-hypusine
A3L04_RS10195	COG2226	methyltransferase
A3L04_RS10210	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
A3L04_RS10225	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
A3L04_RS10245	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
A3L04_RS10255	COG1492	cobalamin metabolic process
A3L04_RS10260	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
A3L04_RS10280	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
A3L04_RS10310	COG1056	cytidyltransferase-related domain
A3L04_RS10310	COG1051	belongs to the nudix hydrolase family
A3L04_RS10330	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
A3L04_RS10345	COG1215	transferase activity, transferring glycosyl groups
A3L04_RS10395	COG0840	transmembrane signaling receptor activity
A3L04_RS10400	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
A3L04_RS10410	COG1058	Belongs to the CinA family
A3L04_RS10410	COG1546	Belongs to the CinA family
A3L04_RS10415	COG2267	carboxylic ester hydrolase activity
A3L04_RS10435	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
A3L04_RS10450	COG0009	L-threonylcarbamoyladenylate synthase
A3L04_RS10470	COG0174	glutamine synthetase
A3L04_RS10490	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A3L04_RS10505	COG0681	Belongs to the peptidase S26 family
A3L04_RS10525	COG4946	Tricorn protease homolog
A3L04_RS10525	COG0823	Involved in the tonB-independent uptake of proteins
A3L04_RS10525	COG1506	peptidase
A3L04_RS10540	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
A3L04_RS10550	COG0517	IMP dehydrogenase activity
A3L04_RS10550	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
A3L04_RS10555	COG0864	Transcriptional regulator
A3L04_RS10685	COG1373	ATPase (AAA superfamily
A3L04_RS10735	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A3L04_RS10735	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A3L04_RS10765	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
A3L04_RS10790	COG0647	UMP catabolic process
A3L04_RS10825	COG0012	GTP binding
A3L04_RS10855	COG0521	Mo-molybdopterin cofactor biosynthetic process
A3L04_RS10860	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
A3L04_RS10865	COG1363	Peptidase, m42
A3L04_RS10870	COG0730	response to heat
A3L04_RS10880	COG0237	dephospho-CoA kinase activity
A3L04_RS10900	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity