locus-tag	class	description
CL1_RS00005	COG0720	synthase
CL1_RS00035	COG1013	pyruvate-flavodoxin oxidoreductase activity
CL1_RS00040	COG0674	pyruvate-flavodoxin oxidoreductase activity
CL1_RS00040	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
CL1_RS00050	COG1013	pyruvate-flavodoxin oxidoreductase activity
CL1_RS00055	COG0674	pyruvate-flavodoxin oxidoreductase activity
CL1_RS00055	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
CL1_RS00080	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
CL1_RS00100	COG1744	ABC transporter substrate-binding protein PnrA-like
CL1_RS00105	COG3845	ABC transporter
CL1_RS00110	COG4603	Belongs to the binding-protein-dependent transport system permease family
CL1_RS00115	COG1079	Belongs to the binding-protein-dependent transport system permease family
CL1_RS00120	COG0803	Belongs to the bacterial solute-binding protein 9 family
CL1_RS00140	COG0215	cysteine-tRNA ligase activity
CL1_RS00170	COG0351	phosphomethylpyrimidine kinase
CL1_RS00170	COG0352	thiamine-phosphate diphosphorylase activity
CL1_RS00175	COG1635	Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur
CL1_RS00185	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
CL1_RS00190	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
CL1_RS00210	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CL1_RS00210	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CL1_RS00215	COG0307	riboflavin synthase, alpha
CL1_RS00220	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CL1_RS00220	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CL1_RS00225	COG1505	serine-type exopeptidase activity
CL1_RS00280	COG0546	phosphoglycolate phosphatase activity
CL1_RS00355	COG2361	Protein of unknown function DUF86
CL1_RS00360	COG1363	Peptidase, m42
CL1_RS00370	COG2409	Drug exporters of the RND superfamily
CL1_RS00395	COG2814	Major facilitator Superfamily
CL1_RS00410	COG2096	Adenosyltransferase
CL1_RS00425	COG1058	Belongs to the CinA family
CL1_RS00425	COG1546	Belongs to the CinA family
CL1_RS00435	COG1872	DUF167
CL1_RS00450	COG0423	glycine-tRNA ligase activity
CL1_RS00470	COG0534	Mate efflux family protein
CL1_RS00490	COG1867	N(2),N(2)-dimethylguanosine tRNA methyltransferase
CL1_RS00505	COG0006	proline dipeptidase activity
CL1_RS00535	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
CL1_RS00535	COG1918	ferrous iron import across plasma membrane
CL1_RS00545	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
CL1_RS00570	COG0730	response to heat
CL1_RS00580	COG0730	response to heat
CL1_RS00590	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CL1_RS00595	COG0442	prolyl-tRNA aminoacylation
CL1_RS00605	COG2192	nodulation
CL1_RS00615	COG0436	Aminotransferase
CL1_RS00625	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
CL1_RS00635	COG1812	S-adenosylmethionine synthetase (AdoMet synthetase)
CL1_RS00645	COG1515	deoxyribonuclease V activity
CL1_RS00680	COG1476	TRANSCRIPTIONal
CL1_RS00690	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CL1_RS00720	COG1941	NADH ubiquinone oxidoreductase 20 kDa subunit
CL1_RS00750	COG0719	Fe-S assembly protein
CL1_RS00755	COG0396	ATPase activity
CL1_RS00780	COG0640	Transcriptional regulator
CL1_RS00790	COG1522	sequence-specific DNA binding
CL1_RS00795	COG1836	PFAM Integral membrane protein DUF92
CL1_RS00800	COG0301	tRNA thio-modification
CL1_RS00800	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CL1_RS00820	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
CL1_RS00905	COG0018	arginyl-trna synthetase
CL1_RS00925	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
CL1_RS00950	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
CL1_RS00960	COG1863	multisubunit Na H antiporter MnhE subunit
CL1_RS00965	COG2212	antiporter activity
CL1_RS00970	COG1320	monovalent cation:proton antiporter activity
CL1_RS00980	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CL1_RS00980	COG2111	Na H antiporter
CL1_RS00985	COG1006	Multisubunit Na H antiporter MnhC subunit
CL1_RS00990	COG0651	ATP synthesis coupled electron transport
CL1_RS00995	COG0651	ATP synthesis coupled electron transport
CL1_RS01005	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CL1_RS01010	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CL1_RS01015	COG0649	NAD binding
CL1_RS01040	COG1522	sequence-specific DNA binding
CL1_RS01090	COG1881	PFAM PEBP family protein
CL1_RS01125	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CL1_RS01135	COG0602	queuosine metabolic process
CL1_RS01180	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
CL1_RS01180	COG0359	binds to the 23S rRNA
CL1_RS01195	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CL1_RS01195	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CL1_RS01250	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
CL1_RS01265	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
CL1_RS01280	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
CL1_RS01290	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CL1_RS01290	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
CL1_RS01325	COG0010	Belongs to the arginase family
CL1_RS01340	COG0475	glutathione-regulated potassium exporter activity
CL1_RS01360	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
CL1_RS01400	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CL1_RS01410	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
CL1_RS01440	COG0252	asparaginase activity
CL1_RS01445	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CL1_RS01450	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
CL1_RS01460	COG1968	undecaprenyl-diphosphatase activity
CL1_RS01475	COG0516	GMP reductase activity
CL1_RS01475	COG0517	IMP dehydrogenase activity
CL1_RS01490	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CL1_RS01495	COG1122	ATPase activity
CL1_RS01535	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
CL1_RS01550	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CL1_RS01560	COG1185	polyribonucleotide nucleotidyltransferase activity
CL1_RS01655	COG0616	signal peptide processing
CL1_RS01665	COG0628	permease
CL1_RS01670	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
CL1_RS01695	COG1131	(ABC) transporter
CL1_RS01710	COG0556	nucleotide-excision repair
CL1_RS01715	COG0101	tRNA pseudouridine synthase activity
CL1_RS01740	COG1063	alcohol dehydrogenase
CL1_RS01745	COG2894	cell division
CL1_RS01765	COG0504	CTP synthase activity
CL1_RS01790	COG1473	amidohydrolase
CL1_RS01805	COG0585	pseudouridine synthase activity
CL1_RS01820	COG0017	Asparaginyl-tRNA synthetase
CL1_RS01830	COG1418	mRNA catabolic process
CL1_RS01855	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
CL1_RS01880	COG1110	DNA topoisomerase II activity
CL1_RS01925	COG1203	CRISPR-associated helicase, Cas3
CL1_RS01935	COG1518	maintenance of DNA repeat elements
CL1_RS01945	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
CL1_RS01975	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CL1_RS01990	COG1458	PINc domain ribonuclease
CL1_RS02015	COG2358	TRAP transporter, solute receptor (TAXI family
CL1_RS02040	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
CL1_RS02045	COG0081	regulation of translation
CL1_RS02070	COG0717	Belongs to the dCTP deaminase family
CL1_RS02095	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CL1_RS02105	COG0058	SHG alpha-glucan phosphorylase activity
CL1_RS02125	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
CL1_RS02140	COG2271	Major facilitator Superfamily
CL1_RS02145	COG2814	Major facilitator Superfamily
CL1_RS02150	COG0584	glycerophosphoryl diester phosphodiesterase
CL1_RS02155	COG0584	glycerophosphoryl diester phosphodiesterase
CL1_RS02165	COG0579	oxidoreductase
CL1_RS02225	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CL1_RS02230	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CL1_RS02260	COG0085	RNA polymerase activity
CL1_RS02265	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
CL1_RS02270	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
CL1_RS02290	COG0049	tRNA binding
CL1_RS02300	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
CL1_RS02330	COG0436	Aminotransferase
CL1_RS02370	COG1185	polyribonucleotide nucleotidyltransferase activity
CL1_RS02385	COG0310	cobalt ion transport
CL1_RS02400	COG1122	ATPase activity
CL1_RS02430	COG2140	Oxalate decarboxylase
CL1_RS02450	COG1234	tRNA 3'-trailer cleavage
CL1_RS02485	COG0489	protein tyrosine kinase activity
CL1_RS02500	COG0746	molybdenum cofactor guanylyltransferase activity
CL1_RS02505	COG0298	carbon dioxide binding
CL1_RS02510	COG0409	Hydrogenase expression formation protein
CL1_RS02515	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
CL1_RS02525	COG1895	HEPN domain
CL1_RS02540	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CL1_RS02555	COG0731	radical SAM domain protein
CL1_RS02555	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
CL1_RS02580	COG0446	pyridine nucleotide-disulphide oxidoreductase
CL1_RS02595	COG1404	Belongs to the peptidase S8 family
CL1_RS02620	COG0574	Belongs to the PEP-utilizing enzyme family
CL1_RS02620	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CL1_RS02625	COG0534	Mate efflux family protein
CL1_RS02630	COG0534	Mate efflux family protein
CL1_RS02635	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
CL1_RS02765	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
CL1_RS02780	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
CL1_RS02785	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
CL1_RS02800	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
CL1_RS02805	COG0733	neurotransmitter:sodium symporter activity
CL1_RS02815	COG0347	Belongs to the P(II) protein family
CL1_RS02820	COG1543	Belongs to the glycosyl hydrolase 57 family
CL1_RS02835	COG0864	Transcriptional regulator
CL1_RS02875	COG0006	proline dipeptidase activity
CL1_RS02880	COG0495	leucyl-tRNA aminoacylation
CL1_RS02895	COG0477	Major facilitator Superfamily
CL1_RS02905	COG0142	geranyltranstransferase activity
CL1_RS02920	COG1304	FMN binding
CL1_RS02935	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
CL1_RS02940	COG1355	regulation of microtubule-based process
CL1_RS02945	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
CL1_RS02960	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CL1_RS02965	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
CL1_RS02980	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
CL1_RS02995	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CL1_RS03005	COG1522	sequence-specific DNA binding
CL1_RS03040	COG0052	Belongs to the universal ribosomal protein uS2 family
CL1_RS03045	COG0148	phosphopyruvate hydratase activity
CL1_RS03065	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
CL1_RS03070	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
CL1_RS03085	COG0202	RNA polymerase activity
CL1_RS03095	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
CL1_RS03100	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
CL1_RS03115	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
CL1_RS03120	COG1028	Short-chain dehydrogenase reductase Sdr
CL1_RS03130	COG1102	Psort location Cytoplasmic, score
CL1_RS03155	COG0200	Binds to the 23S rRNA
CL1_RS03160	COG1841	ribosomal large subunit assembly
CL1_RS03165	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
CL1_RS03170	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
CL1_RS03185	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
CL1_RS03190	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
CL1_RS03200	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
CL1_RS03210	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
CL1_RS03215	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
CL1_RS03220	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
CL1_RS03235	COG0255	Belongs to the universal ribosomal protein uL29 family
CL1_RS03245	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
CL1_RS03250	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
CL1_RS03255	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
CL1_RS03260	COG0089	rRNA binding
CL1_RS03265	COG0088	Forms part of the polypeptide exit tunnel
CL1_RS03270	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
CL1_RS03295	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
CL1_RS03340	COG0543	2 iron, 2 sulfur cluster binding
CL1_RS03350	COG3259	Nickel-dependent hydrogenase
CL1_RS03365	COG0430	RNA-3'-phosphate cyclase activity
CL1_RS03390	COG0305	Participates in initiation and elongation during chromosome replication
CL1_RS03390	COG1372	Participates in initiation and elongation during chromosome replication
CL1_RS03400	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CL1_RS03410	COG5016	pyruvate
CL1_RS03410	COG0511	ligase activity, forming carbon-carbon bonds
CL1_RS03415	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
CL1_RS03420	COG0517	IMP dehydrogenase activity
CL1_RS03420	COG1125	glycine betaine transport
CL1_RS03465	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
CL1_RS03470	COG1185	polyribonucleotide nucleotidyltransferase activity
CL1_RS03525	COG1013	pyruvate-flavodoxin oxidoreductase activity
CL1_RS03550	COG1335	isochorismatase
CL1_RS03560	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
CL1_RS03560	COG2050	protein possibly involved in aromatic compounds catabolism
CL1_RS03565	COG1695	Transcriptional regulator
CL1_RS03590	COG1185	polyribonucleotide nucleotidyltransferase activity
CL1_RS03625	COG0417	DNA replication proofreading
CL1_RS03635	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CL1_RS03635	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CL1_RS03645	COG2078	PFAM AMMECR1 domain protein
CL1_RS03650	COG0011	TIGRFAM Protein of
CL1_RS03675	COG1178	ABC-type Fe3 transport system permease component
CL1_RS03680	COG3842	ATPase activity
CL1_RS03690	COG2252	PERMEase
CL1_RS03740	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
CL1_RS03750	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
CL1_RS03755	COG0218	Necessary for normal cell division and for the maintenance of normal septation
CL1_RS03805	COG0668	transmembrane transport
CL1_RS03810	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CL1_RS03810	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CL1_RS03820	COG2264	protein methyltransferase activity
CL1_RS03890	COG2234	aminopeptidase activity
CL1_RS03990	COG2264	protein methyltransferase activity
CL1_RS04055	COG0519	Catalyzes the synthesis of GMP from XMP
CL1_RS04055	COG0518	GMP synthase (glutamine-hydrolyzing) activity
CL1_RS04070	COG0518	GMP synthase (glutamine-hydrolyzing) activity
CL1_RS04070	COG0519	Catalyzes the synthesis of GMP from XMP
CL1_RS04080	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CL1_RS04085	COG0047	phosphoribosylformylglycinamidine synthase activity
CL1_RS04100	COG0151	Belongs to the GarS family
CL1_RS04105	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
CL1_RS04110	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
CL1_RS04115	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
CL1_RS04125	COG1201	RNA secondary structure unwinding
CL1_RS04130	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
CL1_RS04135	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
CL1_RS04140	COG3383	formate dehydrogenase (NAD+) activity
CL1_RS04145	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
CL1_RS04155	COG0157	Belongs to the NadC ModD family
CL1_RS04165	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
CL1_RS04170	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
CL1_RS04185	COG0516	GMP reductase activity
CL1_RS04185	COG0517	IMP dehydrogenase activity
CL1_RS04200	COG0864	Transcriptional regulator
CL1_RS04250	COG0459	protein refolding
CL1_RS04315	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
CL1_RS04320	COG0463	Glycosyl transferase, family 2
CL1_RS04360	COG0438	transferase activity, transferring glycosyl groups
CL1_RS04365	COG3119	arylsulfatase activity
CL1_RS04370	COG0534	Mate efflux family protein
CL1_RS04410	COG0714	Associated with various cellular activities
CL1_RS04460	COG0438	transferase activity, transferring glycosyl groups
CL1_RS04490	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CL1_RS04505	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
CL1_RS04510	COG1373	ATPase (AAA superfamily
CL1_RS04515	COG0482	sulfurtransferase activity
CL1_RS04550	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
CL1_RS04565	COG1487	ribonuclease activity
CL1_RS04580	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
CL1_RS04590	COG0297	glycogen (starch) synthase activity
CL1_RS04595	COG1378	Sugar-specific transcriptional regulator TrmB
CL1_RS04610	COG1175	transmembrane transport
CL1_RS04615	COG3833	ABC-type maltose transport systems, permease component
CL1_RS04625	COG3842	ATPase activity
CL1_RS04635	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CL1_RS04645	COG1234	tRNA 3'-trailer cleavage
CL1_RS04650	COG1297	OPT oligopeptide transporter protein
CL1_RS04660	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CL1_RS04670	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
CL1_RS04690	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
CL1_RS04725	COG0174	glutamine synthetase
CL1_RS04735	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
CL1_RS04745	COG4608	Belongs to the ABC transporter superfamily
CL1_RS04750	COG0444	Belongs to the ABC transporter superfamily
CL1_RS04755	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CL1_RS04760	COG0601	transmembrane transport
CL1_RS04775	COG0543	2 iron, 2 sulfur cluster binding
CL1_RS04800	COG1606	tRNA processing
CL1_RS04815	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CL1_RS04830	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
CL1_RS04835	COG1436	Produces ATP from ADP in the presence of a proton gradient across the membrane
CL1_RS04845	COG1390	Produces ATP from ADP in the presence of a proton gradient across the membrane
CL1_RS04855	COG1269	ATP hydrolysis coupled proton transport
CL1_RS04865	COG0569	domain protein
CL1_RS04870	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CL1_RS04880	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
CL1_RS04895	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
CL1_RS04950	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
CL1_RS04965	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CL1_RS05005	COG0475	glutathione-regulated potassium exporter activity
CL1_RS05010	COG0517	IMP dehydrogenase activity
CL1_RS05010	COG0516	GMP reductase activity
CL1_RS05015	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
CL1_RS05030	COG0037	tRNA processing
CL1_RS05045	COG1449	Belongs to the glycosyl hydrolase 57 family
CL1_RS05070	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CL1_RS05070	COG4651	solute:proton antiporter activity
CL1_RS05085	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
CL1_RS05095	COG2046	Belongs to the sulfate adenylyltransferase family
CL1_RS05125	COG0529	Catalyzes the synthesis of activated sulfate
CL1_RS05130	COG0730	response to heat
CL1_RS05140	COG3119	arylsulfatase activity
CL1_RS05165	COG3119	arylsulfatase activity
CL1_RS05170	COG0463	Glycosyl transferase, family 2
CL1_RS05170	COG1216	Glycosyl transferase, family 2
CL1_RS05175	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CL1_RS05180	COG0037	tRNA processing
CL1_RS05220	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
CL1_RS05225	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
CL1_RS05245	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
CL1_RS05265	COG0714	Associated with various cellular activities
CL1_RS05285	COG1047	Peptidyl-prolyl cis-trans
CL1_RS05320	COG1160	GTP binding
CL1_RS05340	COG0116	Belongs to the methyltransferase superfamily
CL1_RS05340	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
CL1_RS05350	COG0179	Fumarylacetoacetate (FAA) hydrolase
CL1_RS05370	COG0640	Transcriptional regulator
CL1_RS05395	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
CL1_RS05395	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
CL1_RS05400	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
CL1_RS05400	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
CL1_RS05410	COG0402	S-adenosylhomocysteine deaminase activity
CL1_RS05420	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
CL1_RS05450	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CL1_RS05585	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CL1_RS05630	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
CL1_RS05640	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
CL1_RS05655	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CL1_RS05655	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
CL1_RS05695	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CL1_RS05705	COG0314	molybdopterin synthase activity
CL1_RS05725	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
CL1_RS05730	COG1522	sequence-specific DNA binding
CL1_RS05785	COG0148	phosphopyruvate hydratase activity
CL1_RS05795	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
CL1_RS05810	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
CL1_RS05815	COG0492	ferredoxin-NADP+ reductase activity
CL1_RS05825	COG2255	four-way junction helicase activity
CL1_RS05850	COG0650	Formate hydrogenlyase subunit 4
CL1_RS05860	COG3261	NADH dehydrogenase
CL1_RS05860	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
CL1_RS05865	COG3260	NADH ubiquinone oxidoreductase 20
CL1_RS05875	COG0651	ATP synthesis coupled electron transport
CL1_RS05880	COG1006	Multisubunit Na H antiporter MnhC subunit
CL1_RS05900	COG1320	monovalent cation:proton antiporter activity
CL1_RS05905	COG2212	antiporter activity
CL1_RS05910	COG1863	multisubunit Na H antiporter MnhE subunit
CL1_RS05920	COG0493	'glutamate synthase
CL1_RS05920	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
CL1_RS05925	COG2116	formate transmembrane transporter activity
CL1_RS05940	COG3383	formate dehydrogenase (NAD+) activity
CL1_RS05955	COG3259	Nickel-dependent hydrogenase
CL1_RS05970	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CL1_RS06000	COG0306	phosphate transporter
CL1_RS06015	COG1125	glycine betaine transport
CL1_RS06015	COG0517	IMP dehydrogenase activity
CL1_RS06065	COG4946	Tricorn protease homolog
CL1_RS06065	COG0823	Involved in the tonB-independent uptake of proteins
CL1_RS06065	COG1506	peptidase
CL1_RS06110	COG0681	Belongs to the peptidase S26 family
CL1_RS06115	COG0095	Lipoate-protein ligase
CL1_RS06130	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
CL1_RS06160	COG1346	cytolysis
CL1_RS06165	COG1380	Effector of murein hydrolase LrgA
CL1_RS06180	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
CL1_RS06190	COG1573	uracil-dna glycosylase
CL1_RS06195	COG1757	Na H antiporter
CL1_RS06215	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
CL1_RS06235	COG1522	sequence-specific DNA binding
CL1_RS06250	COG1980	fructose-bisphosphate aldolase activity
CL1_RS06260	COG1233	COG1233 Phytoene dehydrogenase and related
CL1_RS06335	COG2226	methyltransferase
CL1_RS06355	COG0404	The glycine cleavage system catalyzes the degradation of glycine
CL1_RS06360	COG0589	response to stress
CL1_RS06365	COG1628	Protein of unknown function DUF99
CL1_RS06370	COG1324	tolerance protein
CL1_RS06375	COG1254	Belongs to the acylphosphatase family
CL1_RS06385	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CL1_RS06410	COG0489	protein tyrosine kinase activity
CL1_RS06415	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
CL1_RS06420	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CL1_RS06435	COG1013	pyruvate-flavodoxin oxidoreductase activity
CL1_RS06440	COG0674	pyruvate-flavodoxin oxidoreductase activity
CL1_RS06450	COG1013	pyruvate-flavodoxin oxidoreductase activity
CL1_RS06455	COG0674	pyruvate-flavodoxin oxidoreductase activity
CL1_RS06470	COG0306	phosphate transporter
CL1_RS06475	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CL1_RS06520	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
CL1_RS06530	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CL1_RS06540	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
CL1_RS06555	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CL1_RS06570	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
CL1_RS06590	COG0312	modulator of DNA gyrase
CL1_RS06595	COG0312	modulator of DNA gyrase
CL1_RS06645	COG0434	BtpA family
CL1_RS06655	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CL1_RS06665	COG1988	membrane-bound metal-dependent
CL1_RS06700	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
CL1_RS06705	COG0540	Belongs to the ATCase OTCase family
CL1_RS06740	COG3885	ferrous iron binding
CL1_RS06740	COG2078	PFAM AMMECR1 domain protein
CL1_RS06755	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
CL1_RS06760	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
CL1_RS06765	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CL1_RS06780	COG1214	PFAM Peptidase M22, glycoprotease
CL1_RS06780	COG0456	acetyltransferase
CL1_RS06790	COG0156	8-amino-7-oxononanoate synthase activity
CL1_RS06805	COG2255	four-way junction helicase activity
CL1_RS06820	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
CL1_RS06830	COG1530	ribonuclease E activity
CL1_RS06850	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CL1_RS06890	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
CL1_RS06900	COG2814	Major facilitator Superfamily
CL1_RS06910	COG1446	asparaginase
CL1_RS06935	COG2814	Major facilitator Superfamily
CL1_RS06940	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CL1_RS06965	COG2131	deaminase
CL1_RS06970	COG0501	Belongs to the peptidase M48B family
CL1_RS06985	COG0535	radical SAM domain protein
CL1_RS06990	COG2414	aldehyde ferredoxin oxidoreductase
CL1_RS06995	COG1404	Belongs to the peptidase S8 family
CL1_RS07015	COG2151	metal-sulfur cluster biosynthetic enzyme
CL1_RS07020	COG1141	Ferredoxin
CL1_RS07030	COG1028	Short-chain dehydrogenase reductase Sdr
CL1_RS07045	COG0493	'glutamate synthase
CL1_RS07045	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
CL1_RS07050	COG0543	2 iron, 2 sulfur cluster binding
CL1_RS07085	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
CL1_RS07090	COG0167	dihydroorotate dehydrogenase activity
CL1_RS07115	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CL1_RS07130	COG0528	UMP kinase activity
CL1_RS07140	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
CL1_RS07155	COG2814	Major facilitator Superfamily
CL1_RS07165	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
CL1_RS07180	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CL1_RS07195	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
CL1_RS07205	COG0693	protein deglycase activity
CL1_RS07235	COG2095	MarC family integral membrane protein
CL1_RS07240	COG1765	OsmC-like protein
CL1_RS07250	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
CL1_RS07255	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CL1_RS07260	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
CL1_RS07285	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CL1_RS07330	COG0123	including yeast histone deacetylase and acetoin utilization protein
CL1_RS07335	COG0025	NhaP-type Na H and K H
CL1_RS07355	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
CL1_RS07385	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
CL1_RS07390	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
CL1_RS07410	COG0440	acetolactate synthase activity
CL1_RS07415	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CL1_RS07440	COG1320	monovalent cation:proton antiporter activity
CL1_RS07445	COG2212	antiporter activity
CL1_RS07450	COG1863	multisubunit Na H antiporter MnhE subunit
CL1_RS07455	COG0509	glycine decarboxylation via glycine cleavage system
CL1_RS07470	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
CL1_RS07470	COG0493	'glutamate synthase
CL1_RS07475	COG0543	2 iron, 2 sulfur cluster binding
CL1_RS07505	COG0747	negative chemotaxis
CL1_RS07510	COG0601	transmembrane transport
CL1_RS07515	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CL1_RS07520	COG0444	Belongs to the ABC transporter superfamily
CL1_RS07525	COG4608	Belongs to the ABC transporter superfamily
CL1_RS07565	COG1131	(ABC) transporter
CL1_RS07570	COG1476	TRANSCRIPTIONal
CL1_RS07600	COG2119	membrane
CL1_RS07605	COG0436	Aminotransferase
CL1_RS07620	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
CL1_RS07625	COG1192	Involved in chromosome partitioning
CL1_RS07635	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
CL1_RS07635	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
CL1_RS07645	COG0284	orotidine-5'-phosphate decarboxylase activity
CL1_RS07660	COG1213	nucleotidyl transferase
CL1_RS07660	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CL1_RS07675	COG1131	(ABC) transporter
CL1_RS07695	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
CL1_RS07695	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
CL1_RS07720	COG1850	ribulose-bisphosphate carboxylase activity
CL1_RS07770	COG1851	Uncharacterised protein family (UPF0128)
CL1_RS07790	COG1832	CoA-binding protein
CL1_RS07815	COG1160	GTP binding
CL1_RS07845	COG0725	ABC transporter, periplasmic molybdate-binding protein
CL1_RS07850	COG4149	molybdate abc transporter
CL1_RS07855	COG3842	ATPase activity
CL1_RS07870	COG0714	Associated with various cellular activities
CL1_RS07895	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
CL1_RS07900	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
CL1_RS07925	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
CL1_RS07930	COG0560	Phosphoserine phosphatase
CL1_RS07960	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CL1_RS07980	COG1056	cytidyltransferase-related domain
CL1_RS07980	COG1051	belongs to the nudix hydrolase family
CL1_RS08060	COG0778	Nitroreductase
CL1_RS08070	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
CL1_RS08120	COG0071	Belongs to the small heat shock protein (HSP20) family
CL1_RS08125	COG1793	dna ligase
CL1_RS08125	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
CL1_RS08130	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CL1_RS08130	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CL1_RS08155	COG0482	sulfurtransferase activity
CL1_RS08205	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CL1_RS08205	COG1042	CoA-binding domain protein
CL1_RS08205	COG0045	succinate-CoA ligase (ADP-forming) activity
CL1_RS08220	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CL1_RS08230	COG0303	'Molybdopterin
CL1_RS08235	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
CL1_RS08240	COG1373	ATPase (AAA superfamily
CL1_RS08260	COG0009	L-threonylcarbamoyladenylate synthase
CL1_RS08275	COG0367	asparagine synthase
CL1_RS08285	COG2894	cell division
CL1_RS08310	COG0424	maF-like protein
CL1_RS08320	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CL1_RS08320	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
CL1_RS08330	COG0346	lactoylglutathione lyase activity
CL1_RS08340	COG1196	nuclear chromosome segregation
CL1_RS08355	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CL1_RS08395	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
CL1_RS08415	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
CL1_RS08430	COG2894	cell division
CL1_RS08435	COG0330	HflC and HflK could
CL1_RS08450	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
CL1_RS08475	COG2247	cell wall binding repeat
CL1_RS08475	COG0860	N-Acetylmuramoyl-L-alanine amidase
CL1_RS08485	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
CL1_RS08490	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
CL1_RS08495	COG1984	allophanate hydrolase subunit 2
CL1_RS08505	COG1454	alcohol dehydrogenase
CL1_RS08515	COG0483	inositol monophosphate 1-phosphatase activity
CL1_RS08530	COG1199	ATP-dependent helicase activity
CL1_RS08550	COG1489	DNA binding
CL1_RS08555	COG1215	transferase activity, transferring glycosyl groups
CL1_RS08575	COG3473	Maleate cis-trans isomerase
CL1_RS08590	COG0301	tRNA thio-modification
CL1_RS08600	COG0301	tRNA thio-modification
CL1_RS08605	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CL1_RS08615	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CL1_RS08615	COG1042	CoA-binding domain protein
CL1_RS08615	COG0045	succinate-CoA ligase (ADP-forming) activity
CL1_RS08650	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
CL1_RS08685	COG0126	phosphoglycerate kinase activity
CL1_RS08700	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
CL1_RS08710	COG3842	ATPase activity
CL1_RS08715	COG4208	sulfate ABC transporter
CL1_RS08735	COG1522	sequence-specific DNA binding
CL1_RS08740	COG1205	dead DEAH box helicase
CL1_RS08740	COG1111	helicase
CL1_RS08760	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
CL1_RS08765	COG1122	ATPase activity
CL1_RS08770	COG1268	BioY protein
CL1_RS08800	COG0823	Involved in the tonB-independent uptake of proteins
CL1_RS08800	COG1506	peptidase
CL1_RS08800	COG4946	Tricorn protease homolog
CL1_RS08815	COG1444	tRNA N-acetyltransferase activity
CL1_RS08850	COG0017	Asparaginyl-tRNA synthetase
CL1_RS08855	COG0402	S-adenosylhomocysteine deaminase activity
CL1_RS08870	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CL1_RS08890	COG0631	protein serine/threonine phosphatase activity
CL1_RS08895	COG2815	serine threonine protein kinase
CL1_RS08895	COG0515	serine threonine protein kinase
CL1_RS08905	COG0631	protein serine/threonine phosphatase activity
CL1_RS08910	COG2815	serine threonine protein kinase
CL1_RS08910	COG0515	serine threonine protein kinase
CL1_RS08920	COG2815	serine threonine protein kinase
CL1_RS08920	COG0515	serine threonine protein kinase
CL1_RS08925	COG0515	serine threonine protein kinase
CL1_RS08925	COG2815	serine threonine protein kinase
CL1_RS08985	COG0175	sulfate reduction
CL1_RS09025	COG0105	UTP biosynthetic process
CL1_RS09045	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CL1_RS09070	COG0419	ATPase involved in DNA repair
CL1_RS09095	COG0084	hydrolase, TatD family'
CL1_RS09110	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CL1_RS09115	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CL1_RS09135	COG1201	RNA secondary structure unwinding
CL1_RS09150	COG2814	Major facilitator Superfamily
CL1_RS09165	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
CL1_RS09190	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
CL1_RS09195	COG1342	Belongs to the UPF0251 family
CL1_RS09250	COG0489	protein tyrosine kinase activity
CL1_RS09255	COG0455	bacterial-type flagellum organization
CL1_RS09275	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CL1_RS09280	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
CL1_RS09290	COG2267	carboxylic ester hydrolase activity
CL1_RS09305	COG0003	Pfam Anion-transporting ATPase
CL1_RS09315	COG1966	Carbon starvation protein
CL1_RS09325	COG1830	Aldolase
CL1_RS09330	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
CL1_RS09330	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
CL1_RS09335	COG1301	dicarboxylic acid transport
CL1_RS09345	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CL1_RS09350	COG1203	CRISPR-associated helicase, Cas3
CL1_RS09360	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
CL1_RS09365	COG1518	maintenance of DNA repeat elements
CL1_RS09400	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CL1_RS09405	COG0140	phosphoribosyl-ATP diphosphatase activity
CL1_RS09405	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
CL1_RS09410	COG0107	imidazoleglycerol-phosphate synthase activity
CL1_RS09415	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
CL1_RS09420	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
CL1_RS09425	COG0131	Imidazoleglycerol-phosphate dehydratase
CL1_RS09435	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
CL1_RS09495	COG2033	superoxide reductase activity
CL1_RS09500	COG1773	rubredoxin
CL1_RS09505	COG1592	Rubrerythrin
CL1_RS09525	COG0778	Nitroreductase
CL1_RS09540	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
CL1_RS09550	COG2217	Heavy metal translocating P-type atpase
CL1_RS09560	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CL1_RS09605	COG0450	alkyl hydroperoxide reductase
CL1_RS09610	COG0243	molybdopterin cofactor binding
CL1_RS09645	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
CL1_RS09655	COG0546	phosphoglycolate phosphatase activity
CL1_RS09675	COG0477	Major facilitator Superfamily
CL1_RS09680	COG2814	Major facilitator Superfamily
CL1_RS09690	COG0312	modulator of DNA gyrase
CL1_RS09715	COG0668	transmembrane transport
CL1_RS09725	COG1993	acr, cog1993
CL1_RS09730	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
CL1_RS09770	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
CL1_RS09785	COG0531	amino acid
CL1_RS09790	COG0563	adenylate kinase activity
CL1_RS09805	COG0011	TIGRFAM Protein of
CL1_RS09810	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CL1_RS09820	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CL1_RS09845	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
CL1_RS09855	COG1121	(ABC) transporter
CL1_RS09895	COG1401	restriction endodeoxyribonuclease activity
CL1_RS09905	COG1469	GTP cyclohydrolase I activity
CL1_RS09935	COG1078	dGTPase activity
CL1_RS09940	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CL1_RS09950	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CL1_RS09955	COG0051	transcription antitermination factor activity, RNA binding
CL1_RS09965	COG2414	aldehyde ferredoxin oxidoreductase
CL1_RS09970	COG2264	protein methyltransferase activity
CL1_RS09995	COG2403	cyclic 2,3-diphosphoglycerate synthetase activity
CL1_RS10005	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
CL1_RS10025	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
CL1_RS10035	COG1121	(ABC) transporter
CL1_RS10060	COG1353	crispr-associated protein
CL1_RS10070	COG1337	RAMP superfamily
CL1_RS10095	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
CL1_RS10100	COG1518	maintenance of DNA repeat elements
CL1_RS10120	COG1739	Uncharacterized protein family UPF0029
CL1_RS10155	COG1216	Glycosyl transferase, family 2
CL1_RS10180	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
CL1_RS10180	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CL1_RS10210	COG0315	cyclic pyranopterin monophosphate synthase activity
CL1_RS10220	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
CL1_RS10240	COG0459	protein refolding
CL1_RS10250	COG0501	Belongs to the peptidase M48B family
CL1_RS10255	COG0402	S-adenosylhomocysteine deaminase activity
CL1_RS10270	COG0820	rRNA (adenine-C2-)-methyltransferase activity
CL1_RS10275	COG0492	ferredoxin-NADP+ reductase activity
CL1_RS10280	COG1335	isochorismatase
CL1_RS10285	COG1028	Short-chain dehydrogenase reductase Sdr
CL1_RS10290	COG1899	peptidyl-lysine modification to peptidyl-hypusine
CL1_RS10315	COG1078	dGTPase activity
CL1_RS10340	COG0303	'Molybdopterin
CL1_RS10345	COG0521	Mo-molybdopterin cofactor biosynthetic process
CL1_RS10355	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
CL1_RS10360	COG1492	cobalamin metabolic process
CL1_RS10370	COG0746	molybdenum cofactor guanylyltransferase activity
CL1_RS10375	COG2342	PFAM TM1410 hypothetical-related protein
CL1_RS10380	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
CL1_RS10395	COG1573	uracil-dna glycosylase
CL1_RS10400	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
CL1_RS10405	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CL1_RS10410	COG2226	methyltransferase
CL1_RS10415	COG0525	valine-tRNA ligase activity
CL1_RS10435	COG1373	ATPase (AAA superfamily
CL1_RS10445	COG0312	modulator of DNA gyrase
CL1_RS10470	COG0012	GTP binding
CL1_RS10480	COG1522	sequence-specific DNA binding
CL1_RS10485	COG0163	prenyltransferase activity
CL1_RS10550	COG2813	Specifically methylates the guanine in position
CL1_RS10580	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate