locus-tag	class	description
TGAM_RS00005	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
TGAM_RS00005	COG1796	DNA polymerase
TGAM_RS00010	COG0367	asparagine synthase
TGAM_RS00050	COG0714	Associated with various cellular activities
TGAM_RS00085	COG0438	transferase activity, transferring glycosyl groups
TGAM_RS00100	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TGAM_RS00105	COG0037	tRNA processing
TGAM_RS00160	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
TGAM_RS00180	COG0650	Formate hydrogenlyase subunit 4
TGAM_RS00190	COG3261	NADH dehydrogenase
TGAM_RS00190	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
TGAM_RS00195	COG3260	NADH ubiquinone oxidoreductase 20
TGAM_RS00205	COG0651	ATP synthesis coupled electron transport
TGAM_RS00210	COG1006	Multisubunit Na H antiporter MnhC subunit
TGAM_RS00230	COG1320	monovalent cation:proton antiporter activity
TGAM_RS00235	COG2212	antiporter activity
TGAM_RS00245	COG0651	ATP synthesis coupled electron transport
TGAM_RS00250	COG1863	multisubunit Na H antiporter MnhE subunit
TGAM_RS00255	COG1006	Multisubunit Na H antiporter MnhC subunit
TGAM_RS00275	COG2212	antiporter activity
TGAM_RS00280	COG2116	formate transmembrane transporter activity
TGAM_RS00290	COG3260	NADH ubiquinone oxidoreductase 20
TGAM_RS00295	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TGAM_RS00300	COG3261	NADH dehydrogenase
TGAM_RS00300	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
TGAM_RS00305	COG0650	Formate hydrogenlyase subunit 4
TGAM_RS00310	COG0651	ATP synthesis coupled electron transport
TGAM_RS00315	COG0651	ATP synthesis coupled electron transport
TGAM_RS00320	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
TGAM_RS00325	COG0437	4 iron, 4 sulfur cluster binding
TGAM_RS00330	COG3383	formate dehydrogenase (NAD+) activity
TGAM_RS00340	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TGAM_RS00345	COG3259	Nickel-dependent hydrogenase
TGAM_RS00350	COG0437	4 iron, 4 sulfur cluster binding
TGAM_RS00355	COG0493	'glutamate synthase
TGAM_RS00360	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TGAM_RS00365	COG1063	alcohol dehydrogenase
TGAM_RS00370	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
TGAM_RS00390	COG0148	phosphopyruvate hydratase activity
TGAM_RS00430	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
TGAM_RS00450	COG0235	Class ii aldolase
TGAM_RS00460	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
TGAM_RS00470	COG1126	abc transporter atp-binding protein
TGAM_RS00480	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
TGAM_RS00510	COG0095	Lipoate-protein ligase
TGAM_RS00540	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
TGAM_RS00570	COG0823	Involved in the tonB-independent uptake of proteins
TGAM_RS00570	COG1506	peptidase
TGAM_RS00570	COG4946	Tricorn protease homolog
TGAM_RS00595	COG0306	phosphate transporter
TGAM_RS00605	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
TGAM_RS00615	COG1980	fructose-bisphosphate aldolase activity
TGAM_RS00660	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
TGAM_RS00670	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
TGAM_RS00690	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
TGAM_RS00700	COG0402	S-adenosylhomocysteine deaminase activity
TGAM_RS00710	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
TGAM_RS00720	COG1269	ATP hydrolysis coupled proton transport
TGAM_RS00730	COG1390	Produces ATP from ADP in the presence of a proton gradient across the membrane
TGAM_RS00740	COG1436	Produces ATP from ADP in the presence of a proton gradient across the membrane
TGAM_RS00745	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
TGAM_RS00760	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
TGAM_RS00765	COG0482	sulfurtransferase activity
TGAM_RS00850	COG1522	sequence-specific DNA binding
TGAM_RS00855	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
TGAM_RS00875	COG0314	molybdopterin synthase activity
TGAM_RS00895	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
TGAM_RS00910	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
TGAM_RS00915	COG0492	ferredoxin-NADP+ reductase activity
TGAM_RS00925	COG2255	four-way junction helicase activity
TGAM_RS00930	COG0116	Belongs to the methyltransferase superfamily
TGAM_RS00940	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
TGAM_RS00960	COG0714	Associated with various cellular activities
TGAM_RS00980	COG1047	Peptidyl-prolyl cis-trans
TGAM_RS01015	COG1160	GTP binding
TGAM_RS01020	COG0116	Belongs to the methyltransferase superfamily
TGAM_RS01050	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
TGAM_RS01055	COG0704	Plays a role in the regulation of phosphate uptake
TGAM_RS01070	COG0180	Tryptophanyl-tRNA synthetase
TGAM_RS01095	COG1234	tRNA 3'-trailer cleavage
TGAM_RS01110	COG0640	Transcriptional regulator
TGAM_RS01120	COG0640	Transcriptional regulator
TGAM_RS01135	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
TGAM_RS01135	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
TGAM_RS01140	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
TGAM_RS01140	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
TGAM_RS01160	COG0489	protein tyrosine kinase activity
TGAM_RS01165	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TGAM_RS01175	COG0864	Transcriptional regulator
TGAM_RS01185	COG0489	protein tyrosine kinase activity
TGAM_RS01210	COG0746	molybdenum cofactor guanylyltransferase activity
TGAM_RS01225	COG3260	NADH ubiquinone oxidoreductase 20
TGAM_RS01230	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TGAM_RS01235	COG3261	NADH dehydrogenase
TGAM_RS01235	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
TGAM_RS01240	COG0650	Formate hydrogenlyase subunit 4
TGAM_RS01245	COG0651	ATP synthesis coupled electron transport
TGAM_RS01250	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
TGAM_RS01250	COG2111	Na H antiporter
TGAM_RS01260	COG3383	formate dehydrogenase (NAD+) activity
TGAM_RS01265	COG1309	transcriptional regulator
TGAM_RS01280	COG0298	carbon dioxide binding
TGAM_RS01285	COG0409	Hydrogenase expression formation protein
TGAM_RS01290	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
TGAM_RS01315	COG0309	Hydrogenase expression formation protein (HypE)
TGAM_RS01320	COG1013	pyruvate-flavodoxin oxidoreductase activity
TGAM_RS01325	COG0674	pyruvate-flavodoxin oxidoreductase activity
TGAM_RS01335	COG1013	pyruvate-flavodoxin oxidoreductase activity
TGAM_RS01340	COG0674	pyruvate-flavodoxin oxidoreductase activity
TGAM_RS01345	COG1144	Oxidoreductase
TGAM_RS01355	COG0306	phosphate transporter
TGAM_RS01360	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
TGAM_RS01370	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
TGAM_RS01385	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
TGAM_RS01415	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
TGAM_RS01425	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
TGAM_RS01430	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
TGAM_RS01435	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
TGAM_RS01455	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
TGAM_RS01480	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
TGAM_RS01525	COG0517	IMP dehydrogenase activity
TGAM_RS01525	COG0516	GMP reductase activity
TGAM_RS01530	COG0475	glutathione-regulated potassium exporter activity
TGAM_RS01535	COG0475	glutathione-regulated potassium exporter activity
TGAM_RS01540	COG2095	MarC family integral membrane protein
TGAM_RS01550	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
TGAM_RS01555	COG1115	amino acid carrier protein
TGAM_RS01565	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
TGAM_RS01610	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
TGAM_RS01615	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
TGAM_RS01615	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
TGAM_RS01620	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
TGAM_RS01640	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
TGAM_RS01645	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
TGAM_RS01670	COG0543	2 iron, 2 sulfur cluster binding
TGAM_RS01685	COG0601	transmembrane transport
TGAM_RS01690	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TGAM_RS01695	COG0444	Belongs to the ABC transporter superfamily
TGAM_RS01700	COG4608	Belongs to the ABC transporter superfamily
TGAM_RS01715	COG0174	glutamine synthetase
TGAM_RS01755	COG1254	Belongs to the acylphosphatase family
TGAM_RS01760	COG1324	tolerance protein
TGAM_RS01765	COG1628	Protein of unknown function DUF99
TGAM_RS01770	COG0589	response to stress
TGAM_RS01800	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
TGAM_RS01815	COG0167	dihydroorotate dehydrogenase activity
TGAM_RS01840	COG0528	UMP kinase activity
TGAM_RS01855	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
TGAM_RS01870	COG2814	Major facilitator Superfamily
TGAM_RS01875	COG1404	Belongs to the peptidase S8 family
TGAM_RS01900	COG2151	metal-sulfur cluster biosynthetic enzyme
TGAM_RS01905	COG1141	Ferredoxin
TGAM_RS01940	COG2971	BadF BadG BcrA BcrD
TGAM_RS01950	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TGAM_RS01965	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
TGAM_RS01980	COG0673	inositol 2-dehydrogenase activity
TGAM_RS01995	COG4821	SIS domain
TGAM_RS02025	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
TGAM_RS02030	COG0281	malic enzyme
TGAM_RS02040	COG0493	'glutamate synthase
TGAM_RS02040	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
TGAM_RS02045	COG0543	2 iron, 2 sulfur cluster binding
TGAM_RS02090	COG0297	glycogen (starch) synthase activity
TGAM_RS02145	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
TGAM_RS02150	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
TGAM_RS02155	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
TGAM_RS02170	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
TGAM_RS02190	COG0123	including yeast histone deacetylase and acetoin utilization protein
TGAM_RS02200	COG0010	Belongs to the arginase family
TGAM_RS02210	COG0038	chloride channel
TGAM_RS02220	COG2002	toxin-antitoxin pair type II binding
TGAM_RS02225	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
TGAM_RS02245	COG0438	transferase activity, transferring glycosyl groups
TGAM_RS02250	COG0726	polysaccharide deacetylase
TGAM_RS02305	COG1401	restriction endodeoxyribonuclease activity
TGAM_RS02335	COG0183	Belongs to the thiolase family
TGAM_RS02340	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
TGAM_RS02370	COG1522	sequence-specific DNA binding
TGAM_RS02400	COG2252	PERMEase
TGAM_RS02430	COG1458	PINc domain ribonuclease
TGAM_RS02445	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
TGAM_RS02460	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
TGAM_RS02475	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
TGAM_RS02480	COG0081	regulation of translation
TGAM_RS02495	COG0717	Belongs to the dCTP deaminase family
TGAM_RS02575	COG2890	protein-(glutamine-N5) methyltransferase activity
TGAM_RS02580	COG1851	Uncharacterised protein family (UPF0128)
TGAM_RS02595	COG1435	thymidine kinase activity
TGAM_RS02605	COG0330	HflC and HflK could
TGAM_RS02615	COG0175	sulfate reduction
TGAM_RS02665	COG1695	Transcriptional regulator
TGAM_RS02675	COG0393	Putative heavy-metal-binding
TGAM_RS02705	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
TGAM_RS02710	COG2264	protein methyltransferase activity
TGAM_RS02725	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
TGAM_RS02730	COG1492	cobalamin metabolic process
TGAM_RS02740	COG0746	molybdenum cofactor guanylyltransferase activity
TGAM_RS02745	COG2342	PFAM TM1410 hypothetical-related protein
TGAM_RS02750	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
TGAM_RS02775	COG1573	uracil-dna glycosylase
TGAM_RS02780	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
TGAM_RS02785	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
TGAM_RS02835	COG0719	Fe-S assembly protein
TGAM_RS02840	COG0396	ATPase activity
TGAM_RS02855	COG0339	signal peptide processing
TGAM_RS02860	COG0730	response to heat
TGAM_RS02865	COG0730	response to heat
TGAM_RS02875	COG2002	toxin-antitoxin pair type II binding
TGAM_RS02885	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
TGAM_RS02900	COG0731	radical SAM domain protein
TGAM_RS02900	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
TGAM_RS02905	COG0489	protein tyrosine kinase activity
TGAM_RS02910	COG0489	protein tyrosine kinase activity
TGAM_RS02915	COG1342	Belongs to the UPF0251 family
TGAM_RS02940	COG1201	RNA secondary structure unwinding
TGAM_RS02945	COG1812	S-adenosylmethionine synthetase (AdoMet synthetase)
TGAM_RS02975	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
TGAM_RS02995	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
TGAM_RS03025	COG0363	glucosamine-6-phosphate deaminase activity
TGAM_RS03030	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
TGAM_RS03040	COG0297	glycogen (starch) synthase activity
TGAM_RS03045	COG1378	Sugar-specific transcriptional regulator TrmB
TGAM_RS03055	COG2182	Extracellular solute-binding protein
TGAM_RS03060	COG1175	transmembrane transport
TGAM_RS03065	COG3833	ABC-type maltose transport systems, permease component
TGAM_RS03075	COG3842	ATPase activity
TGAM_RS03085	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
TGAM_RS03090	COG1234	tRNA 3'-trailer cleavage
TGAM_RS03095	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
TGAM_RS03115	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
TGAM_RS03140	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
TGAM_RS03155	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
TGAM_RS03160	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
TGAM_RS03170	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
TGAM_RS03200	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
TGAM_RS03205	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
TGAM_RS03210	COG3383	formate dehydrogenase (NAD+) activity
TGAM_RS03225	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
TGAM_RS03230	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
TGAM_RS03235	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
TGAM_RS03240	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
TGAM_RS03260	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
TGAM_RS03275	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
TGAM_RS03380	COG3842	ATPase activity
TGAM_RS03490	COG2264	protein methyltransferase activity
TGAM_RS03515	COG0525	valine-tRNA ligase activity
TGAM_RS03555	COG0012	GTP binding
TGAM_RS03575	COG0018	arginyl-trna synthetase
TGAM_RS03595	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
TGAM_RS03605	COG1863	multisubunit Na H antiporter MnhE subunit
TGAM_RS03610	COG2212	antiporter activity
TGAM_RS03615	COG1320	monovalent cation:proton antiporter activity
TGAM_RS03625	COG2111	Na H antiporter
TGAM_RS03625	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
TGAM_RS03630	COG1006	Multisubunit Na H antiporter MnhC subunit
TGAM_RS03635	COG0651	ATP synthesis coupled electron transport
TGAM_RS03640	COG0651	ATP synthesis coupled electron transport
TGAM_RS03650	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TGAM_RS03660	COG0649	NAD binding
TGAM_RS03685	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
TGAM_RS03700	COG0517	IMP dehydrogenase activity
TGAM_RS03700	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
TGAM_RS03705	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
TGAM_RS03715	COG2403	cyclic 2,3-diphosphoglycerate synthetase activity
TGAM_RS03730	COG0017	Asparaginyl-tRNA synthetase
TGAM_RS03735	COG0402	S-adenosylhomocysteine deaminase activity
TGAM_RS03740	COG0517	IMP dehydrogenase activity
TGAM_RS03740	COG0516	GMP reductase activity
TGAM_RS03745	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
TGAM_RS03755	COG0656	L-ascorbic acid biosynthetic process
TGAM_RS03795	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
TGAM_RS03795	COG1042	CoA-binding domain protein
TGAM_RS03795	COG0045	succinate-CoA ligase (ADP-forming) activity
TGAM_RS03820	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
TGAM_RS03835	COG0151	Belongs to the GarS family
TGAM_RS03860	COG0047	phosphoribosylformylglycinamidine synthase activity
TGAM_RS03865	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
TGAM_RS03880	COG0517	IMP dehydrogenase activity
TGAM_RS03880	COG0516	GMP reductase activity
TGAM_RS03885	COG0518	GMP synthase (glutamine-hydrolyzing) activity
TGAM_RS03885	COG0519	Catalyzes the synthesis of GMP from XMP
TGAM_RS03900	COG0518	GMP synthase (glutamine-hydrolyzing) activity
TGAM_RS03900	COG0519	Catalyzes the synthesis of GMP from XMP
TGAM_RS03995	COG1832	CoA-binding protein
TGAM_RS04025	COG0432	Pfam Uncharacterised protein family UPF0047
TGAM_RS04130	COG1185	polyribonucleotide nucleotidyltransferase activity
TGAM_RS04180	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
TGAM_RS04185	COG4139	cobalamin transport
TGAM_RS04205	COG1151	hydroxylamine reductase activity
TGAM_RS04210	COG1141	Ferredoxin
TGAM_RS04215	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
TGAM_RS04215	COG0493	'glutamate synthase
TGAM_RS04235	COG1230	cation diffusion facilitator family transporter
TGAM_RS04275	COG0798	PFAM Bile acid sodium symporter
TGAM_RS04305	COG0719	Fe-S assembly protein
TGAM_RS04310	COG1137	ATPase activity
TGAM_RS04315	COG0167	dihydroorotate dehydrogenase activity
TGAM_RS04315	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
TGAM_RS04340	COG0535	radical SAM domain protein
TGAM_RS04370	COG0024	Methionine aminopeptidase
TGAM_RS04375	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
TGAM_RS04415	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
TGAM_RS04425	COG0428	transporter
TGAM_RS04440	COG1205	dead DEAH box helicase
TGAM_RS04440	COG1111	helicase
TGAM_RS04450	COG4608	Belongs to the ABC transporter superfamily
TGAM_RS04455	COG0444	Belongs to the ABC transporter superfamily
TGAM_RS04460	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TGAM_RS04465	COG0601	transmembrane transport
TGAM_RS04470	COG0747	negative chemotaxis
TGAM_RS04565	COG0543	2 iron, 2 sulfur cluster binding
TGAM_RS04570	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
TGAM_RS04570	COG0493	'glutamate synthase
TGAM_RS04595	COG0438	transferase activity, transferring glycosyl groups
TGAM_RS04605	COG0509	glycine decarboxylation via glycine cleavage system
TGAM_RS04610	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
TGAM_RS04665	COG1515	deoxyribonuclease V activity
TGAM_RS04675	COG0252	asparaginase activity
TGAM_RS04690	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
TGAM_RS04695	COG1215	transferase activity, transferring glycosyl groups
TGAM_RS04720	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
TGAM_RS04730	COG0312	modulator of DNA gyrase
TGAM_RS04740	COG4946	Tricorn protease homolog
TGAM_RS04740	COG0823	Involved in the tonB-independent uptake of proteins
TGAM_RS04740	COG1506	peptidase
TGAM_RS04775	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
TGAM_RS04785	COG2226	methyltransferase
TGAM_RS04790	COG0011	TIGRFAM Protein of
TGAM_RS04805	COG1966	Carbon starvation protein
TGAM_RS04820	COG0003	Pfam Anion-transporting ATPase
TGAM_RS04845	COG2267	carboxylic ester hydrolase activity
TGAM_RS04855	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
TGAM_RS04910	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
TGAM_RS04920	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
TGAM_RS04985	COG2815	serine threonine protein kinase
TGAM_RS04985	COG0515	serine threonine protein kinase
TGAM_RS04990	COG0631	protein serine/threonine phosphatase activity
TGAM_RS04995	COG2815	serine threonine protein kinase
TGAM_RS04995	COG0515	serine threonine protein kinase
TGAM_RS05035	COG2815	serine threonine protein kinase
TGAM_RS05035	COG0515	serine threonine protein kinase
TGAM_RS05045	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
TGAM_RS05050	COG1522	sequence-specific DNA binding
TGAM_RS05060	COG2234	aminopeptidase activity
TGAM_RS05075	COG0560	Phosphoserine phosphatase
TGAM_RS05125	COG0668	transmembrane transport
TGAM_RS05130	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
TGAM_RS05150	COG0459	protein refolding
TGAM_RS05160	COG3842	ATPase activity
TGAM_RS05165	COG1178	ABC-type Fe3 transport system permease component
TGAM_RS05180	COG1028	Short-chain dehydrogenase reductase Sdr
TGAM_RS05185	COG0493	'glutamate synthase
TGAM_RS05190	COG1899	peptidyl-lysine modification to peptidyl-hypusine
TGAM_RS05195	COG0277	FAD linked oxidase domain protein
TGAM_RS05205	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
TGAM_RS05220	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
TGAM_RS05240	COG0315	cyclic pyranopterin monophosphate synthase activity
TGAM_RS05250	COG1193	negative regulation of DNA recombination
TGAM_RS05255	COG0534	Mate efflux family protein
TGAM_RS05275	COG1505	serine-type exopeptidase activity
TGAM_RS05280	COG0534	Mate efflux family protein
TGAM_RS05285	COG0534	Mate efflux family protein
TGAM_RS05300	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
TGAM_RS05300	COG0574	Belongs to the PEP-utilizing enzyme family
TGAM_RS05305	COG1404	Belongs to the peptidase S8 family
TGAM_RS05330	COG0446	pyridine nucleotide-disulphide oxidoreductase
TGAM_RS05335	COG0442	prolyl-tRNA aminoacylation
TGAM_RS05345	COG2192	nodulation
TGAM_RS05350	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
TGAM_RS05355	COG0051	transcription antitermination factor activity, RNA binding
TGAM_RS05365	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
TGAM_RS05370	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
TGAM_RS05385	COG2095	MarC family integral membrane protein
TGAM_RS05425	COG0693	protein deglycase activity
TGAM_RS05440	COG0546	phosphoglycolate phosphatase activity
TGAM_RS05450	COG2131	deaminase
TGAM_RS05455	COG0501	Belongs to the peptidase M48B family
TGAM_RS05465	COG0436	Aminotransferase
TGAM_RS05470	COG2140	Oxalate decarboxylase
TGAM_RS05475	COG1994	Peptidase M50
TGAM_RS05490	COG1234	tRNA 3'-trailer cleavage
TGAM_RS05510	COG3842	ATPase activity
TGAM_RS05515	COG1178	ABC-type Fe3 transport system permease component
TGAM_RS05525	COG1121	(ABC) transporter
TGAM_RS05535	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
TGAM_RS05555	COG0006	proline dipeptidase activity
TGAM_RS05605	COG1918	ferrous iron import across plasma membrane
TGAM_RS05605	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
TGAM_RS05625	COG0163	prenyltransferase activity
TGAM_RS05630	COG1522	sequence-specific DNA binding
TGAM_RS05695	COG1131	(ABC) transporter
TGAM_RS05705	COG1476	TRANSCRIPTIONal
TGAM_RS05730	COG1013	pyruvate-flavodoxin oxidoreductase activity
TGAM_RS05760	COG1335	isochorismatase
TGAM_RS05790	COG1129	ABC transporter
TGAM_RS05800	COG0343	queuine tRNA-ribosyltransferase activity
TGAM_RS05805	COG0306	phosphate transporter
TGAM_RS05830	COG2894	cell division
TGAM_RS05835	COG1063	alcohol dehydrogenase
TGAM_RS05850	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
TGAM_RS05855	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
TGAM_RS05860	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
TGAM_RS05900	COG1056	cytidyltransferase-related domain
TGAM_RS05900	COG1051	belongs to the nudix hydrolase family
TGAM_RS05915	COG1213	nucleotidyl transferase
TGAM_RS05915	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
TGAM_RS05925	COG0513	Belongs to the DEAD box helicase family
TGAM_RS05950	COG1196	nuclear chromosome segregation
TGAM_RS05965	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
TGAM_RS05985	COG1473	amidohydrolase
TGAM_RS06000	COG1984	allophanate hydrolase subunit 2
TGAM_RS06005	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
TGAM_RS06010	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
TGAM_RS06020	COG2247	cell wall binding repeat
TGAM_RS06020	COG0860	N-Acetylmuramoyl-L-alanine amidase
TGAM_RS06025	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
TGAM_RS06045	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
TGAM_RS06050	COG0482	sulfurtransferase activity
TGAM_RS06110	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
TGAM_RS06125	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TGAM_RS06140	COG0084	hydrolase, TatD family'
TGAM_RS06165	COG2033	superoxide reductase activity
TGAM_RS06175	COG1028	Short-chain dehydrogenase reductase Sdr
TGAM_RS06185	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
TGAM_RS06215	COG2226	methyltransferase
TGAM_RS06240	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
TGAM_RS06245	COG1294	oxidase, subunit
TGAM_RS06250	COG1271	oxidase subunit
TGAM_RS06260	COG0446	pyridine nucleotide-disulphide oxidoreductase
TGAM_RS06285	COG0142	geranyltranstransferase activity
TGAM_RS06290	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
TGAM_RS06295	COG0651	ATP synthesis coupled electron transport
TGAM_RS06300	COG2212	antiporter activity
TGAM_RS06305	COG1320	monovalent cation:proton antiporter activity
TGAM_RS06320	COG1006	Multisubunit Na H antiporter MnhC subunit
TGAM_RS06325	COG1863	multisubunit Na H antiporter MnhE subunit
TGAM_RS06330	COG0651	ATP synthesis coupled electron transport
TGAM_RS06345	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
TGAM_RS06350	COG0450	alkyl hydroperoxide reductase
TGAM_RS06355	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
TGAM_RS06355	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
TGAM_RS06360	COG0307	riboflavin synthase, alpha
TGAM_RS06365	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
TGAM_RS06365	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
TGAM_RS06370	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
TGAM_RS06380	COG0668	transmembrane transport
TGAM_RS06390	COG1215	transferase activity, transferring glycosyl groups
TGAM_RS06420	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
TGAM_RS06425	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
TGAM_RS06430	COG1635	Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur
TGAM_RS06435	COG0351	phosphomethylpyrimidine kinase
TGAM_RS06440	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
TGAM_RS06450	COG0778	Nitroreductase
TGAM_RS06465	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
TGAM_RS06575	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
TGAM_RS06620	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
TGAM_RS06640	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
TGAM_RS06650	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
TGAM_RS06670	COG1078	dGTPase activity
TGAM_RS06675	COG0126	phosphoglycerate kinase activity
TGAM_RS06680	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
TGAM_RS06690	COG0019	diaminopimelate decarboxylase activity
TGAM_RS06715	COG0602	queuosine metabolic process
TGAM_RS06745	COG0436	Aminotransferase
TGAM_RS06750	COG2050	protein possibly involved in aromatic compounds catabolism
TGAM_RS06750	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
TGAM_RS06755	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TGAM_RS06775	COG1444	tRNA N-acetyltransferase activity
TGAM_RS06845	COG0312	modulator of DNA gyrase
TGAM_RS06860	COG1794	racemase activity, acting on amino acids and derivatives
TGAM_RS06865	COG2096	Adenosyltransferase
TGAM_RS06920	COG1363	Peptidase, m42
TGAM_RS06925	COG0720	synthase
TGAM_RS06930	COG1131	(ABC) transporter
TGAM_RS06965	COG1013	pyruvate-flavodoxin oxidoreductase activity
TGAM_RS06970	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
TGAM_RS06970	COG0674	pyruvate-flavodoxin oxidoreductase activity
TGAM_RS06990	COG1013	pyruvate-flavodoxin oxidoreductase activity
TGAM_RS06995	COG0674	pyruvate-flavodoxin oxidoreductase activity
TGAM_RS06995	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
TGAM_RS07030	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
TGAM_RS07050	COG1867	N(2),N(2)-dimethylguanosine tRNA methyltransferase
TGAM_RS07075	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
TGAM_RS07080	COG1078	dGTPase activity
TGAM_RS07100	COG1979	alcohol dehydrogenase
TGAM_RS07110	COG0483	inositol monophosphate 1-phosphatase activity
TGAM_RS07120	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
TGAM_RS07130	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
TGAM_RS07150	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
TGAM_RS07160	COG1446	asparaginase
TGAM_RS07170	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TGAM_RS07170	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TGAM_RS07215	COG2205	protein histidine kinase activity
TGAM_RS07240	COG1469	GTP cyclohydrolase I activity
TGAM_RS07245	COG1160	GTP binding
TGAM_RS07265	COG0725	ABC transporter, periplasmic molybdate-binding protein
TGAM_RS07270	COG4149	molybdate abc transporter
TGAM_RS07275	COG3842	ATPase activity
TGAM_RS07290	COG0521	Mo-molybdopterin cofactor biosynthetic process
TGAM_RS07300	COG0252	asparaginase activity
TGAM_RS07310	COG1695	Transcriptional regulator
TGAM_RS07335	COG0011	TIGRFAM Protein of
TGAM_RS07340	COG2078	PFAM AMMECR1 domain protein
TGAM_RS07345	COG1136	(ABC) transporter
TGAM_RS07360	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
TGAM_RS07360	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
TGAM_RS07365	COG0417	DNA replication proofreading
TGAM_RS07390	COG1185	polyribonucleotide nucleotidyltransferase activity
TGAM_RS07485	COG3473	Maleate cis-trans isomerase
TGAM_RS07495	COG0301	tRNA thio-modification
TGAM_RS07510	COG0301	tRNA thio-modification
TGAM_RS07555	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
TGAM_RS07555	COG0359	binds to the 23S rRNA
TGAM_RS07585	COG0463	Glycosyl transferase, family 2
TGAM_RS07660	COG0546	phosphoglycolate phosphatase activity
TGAM_RS07670	COG0714	Associated with various cellular activities
TGAM_RS07695	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
TGAM_RS07700	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
TGAM_RS07745	COG0643	Histidine kinase
TGAM_RS07745	COG2198	Histidine kinase
TGAM_RS07750	COG2201	protein-glutamate methylesterase activity
TGAM_RS07820	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
TGAM_RS07825	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
TGAM_RS07845	COG0215	cysteine-tRNA ligase activity
TGAM_RS07855	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
TGAM_RS07870	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
TGAM_RS07870	COG0517	IMP dehydrogenase activity
TGAM_RS07880	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
TGAM_RS07885	COG2379	hydroxypyruvate reductase
TGAM_RS07895	COG3842	ATPase activity
TGAM_RS07925	COG0463	Glycosyl transferase, family 2
TGAM_RS07965	COG2814	Major facilitator Superfamily
TGAM_RS07970	COG1201	RNA secondary structure unwinding
TGAM_RS07985	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
TGAM_RS08050	COG0436	Aminotransferase
TGAM_RS08055	COG1605	Chorismate mutase
TGAM_RS08055	COG0287	Prephenate dehydrogenase
TGAM_RS08065	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
TGAM_RS08070	COG0083	homoserine kinase activity
TGAM_RS08075	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
TGAM_RS08080	COG0710	3-dehydroquinate dehydratase activity
TGAM_RS08085	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
TGAM_RS08090	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
TGAM_RS08095	COG3958	Transketolase
TGAM_RS08100	COG3959	Transketolase, thiamine diphosphate binding domain
TGAM_RS08135	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
TGAM_RS08145	COG0131	Imidazoleglycerol-phosphate dehydratase
TGAM_RS08150	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
TGAM_RS08155	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
TGAM_RS08160	COG0107	imidazoleglycerol-phosphate synthase activity
TGAM_RS08165	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
TGAM_RS08165	COG0140	phosphoribosyl-ATP diphosphatase activity
TGAM_RS08170	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
TGAM_RS08180	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
TGAM_RS08215	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
TGAM_RS08250	COG0210	DNA helicase
TGAM_RS08270	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
TGAM_RS08280	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
TGAM_RS08305	COG1744	ABC transporter substrate-binding protein PnrA-like
TGAM_RS08310	COG3845	ABC transporter
TGAM_RS08315	COG4603	Belongs to the binding-protein-dependent transport system permease family
TGAM_RS08320	COG1079	Belongs to the binding-protein-dependent transport system permease family
TGAM_RS08360	COG0628	permease
TGAM_RS08380	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
TGAM_RS08385	COG1131	(ABC) transporter
TGAM_RS08395	COG0556	nucleotide-excision repair
TGAM_RS08400	COG0101	tRNA pseudouridine synthase activity
TGAM_RS08410	COG0463	Glycosyl transferase, family 2
TGAM_RS08415	COG0504	CTP synthase activity
TGAM_RS08425	COG1881	PFAM PEBP family protein
TGAM_RS08440	COG1872	DUF167
TGAM_RS08450	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
TGAM_RS08470	COG1993	acr, cog1993
TGAM_RS08475	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
TGAM_RS08485	COG0010	Belongs to the arginase family
TGAM_RS08505	COG1110	DNA topoisomerase II activity
TGAM_RS08535	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
TGAM_RS08535	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
TGAM_RS08550	COG0071	Belongs to the small heat shock protein (HSP20) family
TGAM_RS08555	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
TGAM_RS08565	COG0584	glycerophosphoryl diester phosphodiesterase
TGAM_RS08575	COG2211	Major facilitator Superfamily
TGAM_RS08585	COG0429	hydrolase of the alpha beta-hydrolase fold
TGAM_RS08595	COG1131	(ABC) transporter
TGAM_RS08600	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
TGAM_RS08605	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
TGAM_RS08620	COG4208	sulfate ABC transporter
TGAM_RS08625	COG3842	ATPase activity
TGAM_RS08630	COG4143	(ABC) transporter
TGAM_RS08635	COG0733	neurotransmitter:sodium symporter activity
TGAM_RS08645	COG0347	Belongs to the P(II) protein family
TGAM_RS08650	COG1543	Belongs to the glycosyl hydrolase 57 family
TGAM_RS08670	COG1757	Na H antiporter
TGAM_RS08695	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
TGAM_RS08700	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
TGAM_RS08705	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
TGAM_RS08720	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
TGAM_RS08725	COG1355	regulation of microtubule-based process
TGAM_RS08750	COG1058	Belongs to the CinA family
TGAM_RS08750	COG1546	Belongs to the CinA family
TGAM_RS08755	COG2414	aldehyde ferredoxin oxidoreductase
TGAM_RS08760	COG0475	glutathione-regulated potassium exporter activity
TGAM_RS08765	COG3620	sequence-specific DNA binding
TGAM_RS08765	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
TGAM_RS08765	COG0617	tRNA 3'-terminal CCA addition
TGAM_RS08770	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
TGAM_RS08775	COG0423	glycine-tRNA ligase activity
TGAM_RS08800	COG0419	ATPase involved in DNA repair
TGAM_RS08800	COG0419	ATPase involved in DNA repair
TGAM_RS08835	COG3291	Pkd domain containing protein
TGAM_RS08860	COG1830	Aldolase
TGAM_RS08865	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
TGAM_RS08865	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
TGAM_RS08870	COG1301	dicarboxylic acid transport
TGAM_RS08920	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
TGAM_RS08925	COG0218	Necessary for normal cell division and for the maintenance of normal septation
TGAM_RS08940	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
TGAM_RS08950	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
TGAM_RS08955	COG0058	SHG alpha-glucan phosphorylase activity
TGAM_RS08965	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
TGAM_RS09000	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
TGAM_RS09010	COG2894	cell division
TGAM_RS09025	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
TGAM_RS09060	COG0579	oxidoreductase
TGAM_RS09115	COG1122	ATPase activity
TGAM_RS09125	COG1268	BioY protein
TGAM_RS09140	COG0527	aspartate kinase activity
TGAM_RS09145	COG0083	homoserine kinase activity
TGAM_RS09150	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
TGAM_RS09155	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
TGAM_RS09160	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
TGAM_RS09175	COG1573	uracil-dna glycosylase
TGAM_RS09185	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
TGAM_RS09205	COG1346	cytolysis
TGAM_RS09225	COG1525	nuclease
TGAM_RS09235	COG1304	FMN binding
TGAM_RS09245	COG0142	geranyltranstransferase activity
TGAM_RS09265	COG0495	leucyl-tRNA aminoacylation
TGAM_RS09275	COG0006	proline dipeptidase activity
TGAM_RS09300	COG2119	membrane
TGAM_RS09305	COG0436	Aminotransferase
TGAM_RS09320	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
TGAM_RS09325	COG1192	Involved in chromosome partitioning
TGAM_RS09335	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
TGAM_RS09335	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
TGAM_RS09345	COG0284	orotidine-5'-phosphate decarboxylase activity
TGAM_RS09365	COG1175	transmembrane transport
TGAM_RS09370	COG3833	ABC-type maltose transport systems, permease component
TGAM_RS09375	COG3842	ATPase activity
TGAM_RS09380	COG1213	nucleotidyl transferase
TGAM_RS09380	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
TGAM_RS09390	COG0531	amino acid
TGAM_RS09405	COG1131	(ABC) transporter
TGAM_RS09450	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
TGAM_RS09455	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
TGAM_RS09465	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
TGAM_RS09475	COG0105	UTP biosynthetic process
TGAM_RS09495	COG0585	pseudouridine synthase activity
TGAM_RS09510	COG0017	Asparaginyl-tRNA synthetase
TGAM_RS09520	COG1418	mRNA catabolic process
TGAM_RS09555	COG0546	phosphoglycolate phosphatase activity
TGAM_RS09570	COG2358	TRAP transporter, solute receptor (TAXI family
TGAM_RS09595	COG1522	sequence-specific DNA binding
TGAM_RS09600	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
TGAM_RS09610	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
TGAM_RS09615	COG0330	HflC and HflK could
TGAM_RS09620	COG0616	signal peptide processing
TGAM_RS09670	COG0513	Belongs to the DEAD box helicase family
TGAM_RS09695	COG2414	aldehyde ferredoxin oxidoreductase
TGAM_RS09705	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
TGAM_RS09725	COG0049	tRNA binding
TGAM_RS09745	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
TGAM_RS09750	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
TGAM_RS09755	COG0085	RNA polymerase activity
TGAM_RS09775	COG0346	lactoylglutathione lyase activity
TGAM_RS09785	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
TGAM_RS09785	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
TGAM_RS09795	COG0424	maF-like protein
TGAM_RS09805	COG4956	integral membrane protein (PIN domain superfamily)
TGAM_RS09810	COG2894	cell division
TGAM_RS09820	COG0367	asparagine synthase
TGAM_RS09830	COG0009	L-threonylcarbamoyladenylate synthase
TGAM_RS09845	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
TGAM_RS09850	COG0303	'Molybdopterin
TGAM_RS09860	COG1522	sequence-specific DNA binding
TGAM_RS09870	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
TGAM_RS09885	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
TGAM_RS09900	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
TGAM_RS09945	COG0052	Belongs to the universal ribosomal protein uS2 family
TGAM_RS09950	COG0148	phosphopyruvate hydratase activity
TGAM_RS09970	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
TGAM_RS09975	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
TGAM_RS09990	COG0202	RNA polymerase activity
TGAM_RS10000	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
TGAM_RS10005	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
TGAM_RS10020	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
TGAM_RS10030	COG1102	Psort location Cytoplasmic, score
TGAM_RS10055	COG0200	Binds to the 23S rRNA
TGAM_RS10060	COG1841	ribosomal large subunit assembly
TGAM_RS10065	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
TGAM_RS10070	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
TGAM_RS10085	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
TGAM_RS10090	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
TGAM_RS10100	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
TGAM_RS10110	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
TGAM_RS10115	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
TGAM_RS10120	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
TGAM_RS10135	COG0255	Belongs to the universal ribosomal protein uL29 family
TGAM_RS10140	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
TGAM_RS10145	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
TGAM_RS10150	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
TGAM_RS10155	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
TGAM_RS10160	COG0089	rRNA binding
TGAM_RS10170	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
TGAM_RS10210	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
TGAM_RS10225	COG0017	Asparaginyl-tRNA synthetase
TGAM_RS10240	COG1487	ribonuclease activity
TGAM_RS10250	COG0430	RNA-3'-phosphate cyclase activity
TGAM_RS10270	COG1372	Participates in initiation and elongation during chromosome replication
TGAM_RS10270	COG0305	Participates in initiation and elongation during chromosome replication
TGAM_RS10280	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
TGAM_RS10290	COG0511	ligase activity, forming carbon-carbon bonds
TGAM_RS10290	COG5016	pyruvate
TGAM_RS10295	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
TGAM_RS10300	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
TGAM_RS10300	COG0517	IMP dehydrogenase activity
TGAM_RS10305	COG0460	homoserine dehydrogenase
TGAM_RS10330	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
TGAM_RS10335	COG1185	polyribonucleotide nucleotidyltransferase activity
TGAM_RS10350	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
TGAM_RS10375	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
TGAM_RS10415	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
TGAM_RS10430	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
TGAM_RS10435	COG1120	ATPase activity
TGAM_RS10440	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TGAM_RS10445	COG0456	acetyltransferase
TGAM_RS10470	COG0156	8-amino-7-oxononanoate synthase activity
TGAM_RS10480	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
TGAM_RS10485	COG2255	four-way junction helicase activity
TGAM_RS10495	COG2361	Protein of unknown function DUF86
TGAM_RS10510	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
TGAM_RS10520	COG3557	Belongs to the UPF0374 family
TGAM_RS10535	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
TGAM_RS10540	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
TGAM_RS10550	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
TGAM_RS10560	COG2078	PFAM AMMECR1 domain protein
TGAM_RS10560	COG3885	ferrous iron binding
TGAM_RS10605	COG0540	Belongs to the ATCase OTCase family
TGAM_RS10610	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
TGAM_RS10635	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
TGAM_RS10655	COG0434	BtpA family
TGAM_RS10695	COG0312	modulator of DNA gyrase
TGAM_RS10730	COG2226	methyltransferase
TGAM_RS10795	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TGAM_RS10805	COG0037	tRNA processing
TGAM_RS10815	COG1449	Belongs to the glycosyl hydrolase 57 family
TGAM_RS10850	COG2244	polysaccharide biosynthetic process
TGAM_RS10865	COG0297	glycogen (starch) synthase activity
TGAM_RS10865	COG0438	transferase activity, transferring glycosyl groups
TGAM_RS10885	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
TGAM_RS10890	COG1210	Utp--glucose-1-phosphate uridylyltransferase
TGAM_RS10895	COG1216	Glycosyl transferase, family 2
TGAM_RS10895	COG0463	Glycosyl transferase, family 2
TGAM_RS10910	COG0673	inositol 2-dehydrogenase activity
TGAM_RS10925	COG0463	Glycosyl transferase, family 2
TGAM_RS10935	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
TGAM_RS10940	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
TGAM_RS10965	COG0515	serine threonine protein kinase
TGAM_RS10965	COG2815	serine threonine protein kinase
TGAM_RS11020	COG2815	serine threonine protein kinase
TGAM_RS11020	COG0515	serine threonine protein kinase
TGAM_RS11030	COG0515	serine threonine protein kinase
TGAM_RS11030	COG2815	serine threonine protein kinase
TGAM_RS11075	COG2813	Specifically methylates the guanine in position