locus-tag	class	description
TK_RS00015	COG1451	nucleotide metabolic process
TK_RS00030	COG1832	CoA-binding protein
TK_RS00065	COG1160	GTP binding
TK_RS00080	COG0725	ABC transporter, periplasmic molybdate-binding protein
TK_RS00095	COG4149	molybdate abc transporter
TK_RS00100	COG1106	Psort location Cytoplasmic, score
TK_RS00135	COG0546	phosphoglycolate phosphatase activity
TK_RS00145	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
TK_RS00155	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
TK_RS00195	COG2226	methyltransferase
TK_RS00270	COG0560	Phosphoserine phosphatase
TK_RS00300	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
TK_RS00340	COG1056	cytidyltransferase-related domain
TK_RS00340	COG1051	belongs to the nudix hydrolase family
TK_RS00365	COG2414	aldehyde ferredoxin oxidoreductase
TK_RS00395	COG1404	Belongs to the peptidase S8 family
TK_RS00530	COG1321	iron dependent repressor
TK_RS00570	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
TK_RS00610	COG2814	Major facilitator Superfamily
TK_RS00620	COG0456	acetyltransferase
TK_RS00660	COG0123	including yeast histone deacetylase and acetoin utilization protein
TK_RS00690	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
TK_RS00720	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
TK_RS00735	COG0509	glycine decarboxylation via glycine cleavage system
TK_RS00760	COG1185	polyribonucleotide nucleotidyltransferase activity
TK_RS00770	COG2252	PERMEase
TK_RS00775	COG3842	ATPase activity
TK_RS00780	COG4149	molybdate abc transporter
TK_RS00850	COG0011	TIGRFAM Protein of
TK_RS00855	COG2078	PFAM AMMECR1 domain protein
TK_RS00885	COG0183	Belongs to the thiolase family
TK_RS00890	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
TK_RS00910	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
TK_RS00915	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
TK_RS00920	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
TK_RS00930	COG1765	OsmC-like protein
TK_RS00935	COG0518	GMP synthase (glutamine-hydrolyzing) activity
TK_RS00935	COG0519	Catalyzes the synthesis of GMP from XMP
TK_RS00950	COG0519	Catalyzes the synthesis of GMP from XMP
TK_RS00950	COG0518	GMP synthase (glutamine-hydrolyzing) activity
TK_RS00955	COG0517	IMP dehydrogenase activity
TK_RS00955	COG0516	GMP reductase activity
TK_RS00970	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
TK_RS00975	COG2814	Major facilitator Superfamily
TK_RS00985	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
TK_RS00985	COG0574	Belongs to the PEP-utilizing enzyme family
TK_RS00990	COG0047	phosphoribosylformylglycinamidine synthase activity
TK_RS01005	COG0151	Belongs to the GarS family
TK_RS01020	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
TK_RS01025	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
TK_RS01030	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
TK_RS01035	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
TK_RS01050	COG3383	formate dehydrogenase (NAD+) activity
TK_RS01060	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
TK_RS01070	COG0157	Belongs to the NadC ModD family
TK_RS01075	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
TK_RS01100	COG2226	methyltransferase
TK_RS01150	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
TK_RS01180	COG0010	Belongs to the arginase family
TK_RS01195	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
TK_RS01205	COG0131	Imidazoleglycerol-phosphate dehydratase
TK_RS01210	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
TK_RS01215	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
TK_RS01220	COG0107	imidazoleglycerol-phosphate synthase activity
TK_RS01225	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
TK_RS01225	COG0140	phosphoribosyl-ATP diphosphatase activity
TK_RS01230	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
TK_RS01250	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
TK_RS01255	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
TK_RS01255	COG0512	Glutamine amidotransferase of anthranilate synthase
TK_RS01265	COG0133	tryptophan synthase activity
TK_RS01270	COG0159	tryptophan synthase activity
TK_RS01280	COG0436	Aminotransferase
TK_RS01300	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
TK_RS01305	COG0710	3-dehydroquinate dehydratase activity
TK_RS01310	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
TK_RS01315	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
TK_RS01320	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
TK_RS01340	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
TK_RS01345	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
TK_RS01355	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
TK_RS01360	COG0189	ligase activity
TK_RS01370	COG0473	3-isopropylmalate dehydrogenase activity
TK_RS01375	COG0066	3-isopropylmalate dehydratase activity
TK_RS01380	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
TK_RS01385	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
TK_RS01390	COG0778	Nitroreductase
TK_RS01400	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
TK_RS01410	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
TK_RS01440	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
TK_RS01445	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
TK_RS01490	COG0528	UMP kinase activity
TK_RS01505	COG0513	Belongs to the DEAD box helicase family
TK_RS01515	COG0051	transcription antitermination factor activity, RNA binding
TK_RS01520	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
TK_RS01525	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
TK_RS01540	COG1078	dGTPase activity
TK_RS01545	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
TK_RS01550	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TK_RS01565	COG0084	hydrolase, TatD family'
TK_RS01610	COG1131	(ABC) transporter
TK_RS01615	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
TK_RS01620	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
TK_RS01620	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
TK_RS01630	COG0346	lactoylglutathione lyase activity
TK_RS01640	COG1984	allophanate hydrolase subunit 2
TK_RS01645	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
TK_RS01660	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
TK_RS01670	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
TK_RS01700	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
TK_RS01715	COG0330	HflC and HflK could
TK_RS01720	COG2894	cell division
TK_RS01735	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
TK_RS01745	COG0315	cyclic pyranopterin monophosphate synthase activity
TK_RS01750	COG1131	(ABC) transporter
TK_RS01760	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
TK_RS01775	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
TK_RS01775	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
TK_RS01790	COG1216	Glycosyl transferase, family 2
TK_RS01805	COG0301	tRNA thio-modification
TK_RS01815	COG0301	tRNA thio-modification
TK_RS02085	COG1505	serine-type exopeptidase activity
TK_RS02090	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
TK_RS02090	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
TK_RS02095	COG0307	riboflavin synthase, alpha
TK_RS02110	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
TK_RS02110	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
TK_RS02115	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
TK_RS02130	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
TK_RS02140	COG1635	Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur
TK_RS02145	COG0352	thiamine-phosphate diphosphorylase activity
TK_RS02145	COG0351	phosphomethylpyrimidine kinase
TK_RS02150	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
TK_RS02190	COG0215	cysteine-tRNA ligase activity
TK_RS02195	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
TK_RS02245	COG1518	maintenance of DNA repeat elements
TK_RS02265	COG1466	dna polymerase III delta subunit
TK_RS02270	COG1203	CRISPR-associated helicase, Cas3
TK_RS02320	COG1110	DNA topoisomerase II activity
TK_RS02340	COG0010	Belongs to the arginase family
TK_RS02345	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
TK_RS02355	COG0546	phosphoglycolate phosphatase activity
TK_RS02370	COG1418	mRNA catabolic process
TK_RS02430	COG0017	Asparaginyl-tRNA synthetase
TK_RS02440	COG1473	amidohydrolase
TK_RS02460	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
TK_RS02470	COG0312	modulator of DNA gyrase
TK_RS02485	COG0312	modulator of DNA gyrase
TK_RS02500	COG0598	Magnesium transport protein CorA
TK_RS02505	COG0012	GTP binding
TK_RS02515	COG1522	sequence-specific DNA binding
TK_RS02520	COG0163	prenyltransferase activity
TK_RS02530	COG0469	pyruvate kinase activity
TK_RS02545	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
TK_RS02550	COG1993	acr, cog1993
TK_RS02570	COG1739	Uncharacterized protein family UPF0029
TK_RS02580	COG1205	dead DEAH box helicase
TK_RS02580	COG1111	helicase
TK_RS02590	COG1592	Rubrerythrin
TK_RS02595	COG1773	rubredoxin
TK_RS02600	COG2033	superoxide reductase activity
TK_RS02645	COG0450	alkyl hydroperoxide reductase
TK_RS02660	COG1078	dGTPase activity
TK_RS02670	COG0303	'Molybdopterin
TK_RS02685	COG1812	S-adenosylmethionine synthetase (AdoMet synthetase)
TK_RS02695	COG0420	3'-5' exonuclease activity
TK_RS02700	COG0436	Aminotransferase
TK_RS02705	COG2192	nodulation
TK_RS02710	COG0442	prolyl-tRNA aminoacylation
TK_RS02715	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
TK_RS02740	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
TK_RS02750	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
TK_RS02765	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
TK_RS02770	COG1342	Belongs to the UPF0251 family
TK_RS02795	COG1522	sequence-specific DNA binding
TK_RS02815	COG4208	sulfate ABC transporter
TK_RS02820	COG3842	ATPase activity
TK_RS02975	COG3842	ATPase activity
TK_RS03055	COG1863	multisubunit Na H antiporter MnhE subunit
TK_RS03060	COG2212	antiporter activity
TK_RS03065	COG1320	monovalent cation:proton antiporter activity
TK_RS03090	COG0651	ATP synthesis coupled electron transport
TK_RS03095	COG0440	acetolactate synthase activity
TK_RS03115	COG0840	transmembrane signaling receptor activity
TK_RS03120	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
TK_RS03125	COG2201	protein-glutamate methylesterase activity
TK_RS03130	COG2201	protein-glutamate methylesterase activity
TK_RS03150	COG0840	transmembrane signaling receptor activity
TK_RS03155	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
TK_RS03185	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
TK_RS03205	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TK_RS03205	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TK_RS03245	COG1744	ABC transporter substrate-binding protein PnrA-like
TK_RS03250	COG3845	ABC transporter
TK_RS03255	COG4603	Belongs to the binding-protein-dependent transport system permease family
TK_RS03260	COG1079	Belongs to the binding-protein-dependent transport system permease family
TK_RS03285	COG0045	succinate-CoA ligase (ADP-forming) activity
TK_RS03285	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
TK_RS03285	COG1042	CoA-binding domain protein
TK_RS03305	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
TK_RS03315	COG1899	peptidyl-lysine modification to peptidyl-hypusine
TK_RS03320	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
TK_RS03320	COG0493	'glutamate synthase
TK_RS03325	COG1028	Short-chain dehydrogenase reductase Sdr
TK_RS03345	COG0501	Belongs to the peptidase M48B family
TK_RS03355	COG0515	serine threonine protein kinase
TK_RS03370	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
TK_RS03375	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
TK_RS03385	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
TK_RS03390	COG1011	Hydrolase
TK_RS03410	COG0243	molybdopterin cofactor binding
TK_RS03450	COG0312	modulator of DNA gyrase
TK_RS03465	COG0489	protein tyrosine kinase activity
TK_RS03470	COG0489	protein tyrosine kinase activity
TK_RS03475	COG0731	radical SAM domain protein
TK_RS03475	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
TK_RS03480	COG2226	methyltransferase
TK_RS03485	COG1012	belongs to the aldehyde dehydrogenase family
TK_RS03490	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
TK_RS03495	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TK_RS03500	COG1120	ATPase activity
TK_RS03530	COG1918	ferrous iron import across plasma membrane
TK_RS03530	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
TK_RS03545	COG0725	ABC transporter, periplasmic molybdate-binding protein
TK_RS03555	COG3842	ATPase activity
TK_RS03595	COG1131	(ABC) transporter
TK_RS03610	COG0719	Fe-S assembly protein
TK_RS03615	COG0396	ATPase activity
TK_RS03635	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TK_RS03680	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
TK_RS03685	COG1122	ATPase activity
TK_RS03690	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
TK_RS03690	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
TK_RS03695	COG1268	BioY protein
TK_RS03715	COG4946	Tricorn protease homolog
TK_RS03715	COG0823	Involved in the tonB-independent uptake of proteins
TK_RS03715	COG1506	peptidase
TK_RS03725	COG1444	tRNA N-acetyltransferase activity
TK_RS03740	COG4143	(ABC) transporter
TK_RS03745	COG0402	S-adenosylhomocysteine deaminase activity
TK_RS03750	COG0017	Asparaginyl-tRNA synthetase
TK_RS03770	COG1215	transferase activity, transferring glycosyl groups
TK_RS03780	COG1201	RNA secondary structure unwinding
TK_RS03780	COG1201	RNA secondary structure unwinding
TK_RS03800	COG1872	DUF167
TK_RS03830	COG1363	Peptidase, m42
TK_RS03840	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
TK_RS03850	COG1489	DNA binding
TK_RS03875	COG1199	ATP-dependent helicase activity
TK_RS03890	COG0457	Tetratricopeptide repeat
TK_RS03890	COG0705	Rhomboid family
TK_RS03895	COG0483	inositol monophosphate 1-phosphatase activity
TK_RS03905	COG1979	alcohol dehydrogenase
TK_RS03925	COG1469	GTP cyclohydrolase I activity
TK_RS03935	COG1401	restriction endodeoxyribonuclease activity
TK_RS03955	COG2205	protein histidine kinase activity
TK_RS03975	COG1121	(ABC) transporter
TK_RS03985	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
TK_RS04005	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
TK_RS04020	COG0563	adenylate kinase activity
TK_RS04030	COG1773	rubredoxin
TK_RS04030	COG0426	domain, Protein
TK_RS04040	COG1013	pyruvate-flavodoxin oxidoreductase activity
TK_RS04050	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
TK_RS04050	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
TK_RS04095	COG0446	pyridine nucleotide-disulphide oxidoreductase
TK_RS04125	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
TK_RS04130	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
TK_RS04135	COG2217	Heavy metal translocating P-type atpase
TK_RS04160	COG0798	PFAM Bile acid sodium symporter
TK_RS04165	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
TK_RS04175	COG0667	Aldo Keto reductase
TK_RS04200	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
TK_RS04210	COG1492	cobalamin metabolic process
TK_RS04220	COG0746	molybdenum cofactor guanylyltransferase activity
TK_RS04225	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
TK_RS04255	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
TK_RS04260	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
TK_RS04265	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
TK_RS04270	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
TK_RS04290	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
TK_RS04295	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
TK_RS04350	COG0010	Belongs to the arginase family
TK_RS04360	COG0475	glutathione-regulated potassium exporter activity
TK_RS04390	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
TK_RS04435	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
TK_RS04470	COG1515	deoxyribonuclease V activity
TK_RS04480	COG0252	asparaginase activity
TK_RS04495	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
TK_RS04515	COG2894	cell division
TK_RS04520	COG1063	alcohol dehydrogenase
TK_RS04565	COG0101	tRNA pseudouridine synthase activity
TK_RS04570	COG0556	nucleotide-excision repair
TK_RS04605	COG2358	TRAP transporter, solute receptor (TAXI family
TK_RS04635	COG1131	(ABC) transporter
TK_RS04640	COG1042	CoA-binding domain protein
TK_RS04640	COG0045	succinate-CoA ligase (ADP-forming) activity
TK_RS04640	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
TK_RS04665	COG0009	L-threonylcarbamoyladenylate synthase
TK_RS04675	COG0367	asparagine synthase
TK_RS04685	COG2894	cell division
TK_RS04690	COG4956	integral membrane protein (PIN domain superfamily)
TK_RS04695	COG0424	maF-like protein
TK_RS04700	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
TK_RS04710	COG1918	ferrous iron import across plasma membrane
TK_RS04710	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
TK_RS04720	COG4818	TM2 domain
TK_RS04760	COG0006	proline dipeptidase activity
TK_RS04775	COG1867	N(2),N(2)-dimethylguanosine tRNA methyltransferase
TK_RS04795	COG0534	Mate efflux family protein
TK_RS04815	COG0423	glycine-tRNA ligase activity
TK_RS04820	COG0730	response to heat
TK_RS04830	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
TK_RS04845	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
TK_RS04855	COG1301	dicarboxylic acid transport
TK_RS04860	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
TK_RS04860	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
TK_RS04870	COG1830	Aldolase
TK_RS04880	COG1966	Carbon starvation protein
TK_RS04895	COG0003	Pfam Anion-transporting ATPase
TK_RS04900	COG2151	metal-sulfur cluster biosynthetic enzyme
TK_RS04920	COG2267	carboxylic ester hydrolase activity
TK_RS04935	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
TK_RS04945	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
TK_RS04970	COG1401	restriction endodeoxyribonuclease activity
TK_RS04995	COG1201	RNA secondary structure unwinding
TK_RS05005	COG1196	nuclear chromosome segregation
TK_RS05050	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
TK_RS05075	COG1129	ABC transporter
TK_RS05100	COG0517	IMP dehydrogenase activity
TK_RS05100	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
TK_RS05105	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
TK_RS05115	COG2403	cyclic 2,3-diphosphoglycerate synthetase activity
TK_RS05140	COG2814	Major facilitator Superfamily
TK_RS05145	COG2096	Adenosyltransferase
TK_RS05155	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
TK_RS05160	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
TK_RS05185	COG0730	response to heat
TK_RS05195	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
TK_RS05230	COG0668	transmembrane transport
TK_RS05245	COG2414	aldehyde ferredoxin oxidoreductase
TK_RS05265	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
TK_RS05285	COG2002	toxin-antitoxin pair type II binding
TK_RS05290	COG0049	tRNA binding
TK_RS05310	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
TK_RS05315	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
TK_RS05320	COG0085	RNA polymerase activity
TK_RS05360	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
TK_RS05375	COG0436	Aminotransferase
TK_RS05405	COG1185	polyribonucleotide nucleotidyltransferase activity
TK_RS05420	COG0310	cobalt ion transport
TK_RS05435	COG1122	ATPase activity
TK_RS05460	COG2140	Oxalate decarboxylase
TK_RS05475	COG1234	tRNA 3'-trailer cleavage
TK_RS05485	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
TK_RS05505	COG0720	synthase
TK_RS05530	COG1013	pyruvate-flavodoxin oxidoreductase activity
TK_RS05535	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
TK_RS05535	COG0674	pyruvate-flavodoxin oxidoreductase activity
TK_RS05555	COG1013	pyruvate-flavodoxin oxidoreductase activity
TK_RS05560	COG0674	pyruvate-flavodoxin oxidoreductase activity
TK_RS05560	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
TK_RS05595	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
TK_RS05615	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
TK_RS05620	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
TK_RS05625	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
TK_RS05650	COG0126	phosphoglycerate kinase activity
TK_RS05665	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
TK_RS05665	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
TK_RS05695	COG0071	Belongs to the small heat shock protein (HSP20) family
TK_RS05705	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
TK_RS05715	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
TK_RS05720	COG0628	permease
TK_RS05760	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
TK_RS05775	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
TK_RS05815	COG1122	ATPase activity
TK_RS05820	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
TK_RS05825	COG0024	Methionine aminopeptidase
TK_RS05845	COG0516	GMP reductase activity
TK_RS05845	COG0517	IMP dehydrogenase activity
TK_RS05865	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
TK_RS05880	COG0504	CTP synthase activity
TK_RS05905	COG0602	queuosine metabolic process
TK_RS05910	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
TK_RS05945	COG1881	PFAM PEBP family protein
TK_RS05995	COG0649	NAD binding
TK_RS06000	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TK_RS06005	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TK_RS06015	COG0651	ATP synthesis coupled electron transport
TK_RS06020	COG0651	ATP synthesis coupled electron transport
TK_RS06030	COG2111	Na H antiporter
TK_RS06030	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
TK_RS06040	COG1320	monovalent cation:proton antiporter activity
TK_RS06050	COG1863	multisubunit Na H antiporter MnhE subunit
TK_RS06060	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
TK_RS06075	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
TK_RS06095	COG0018	arginyl-trna synthetase
TK_RS06105	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
TK_RS06180	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
TK_RS06185	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
TK_RS06210	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
TK_RS06210	COG0301	tRNA thio-modification
TK_RS06215	COG1836	PFAM Integral membrane protein DUF92
TK_RS06220	COG1522	sequence-specific DNA binding
TK_RS06225	COG1694	Mazg nucleotide pyrophosphohydrolase
TK_RS06230	COG0640	Transcriptional regulator
TK_RS06245	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
TK_RS06255	COG1476	TRANSCRIPTIONal
TK_RS06295	COG2226	methyltransferase
TK_RS06300	COG0525	valine-tRNA ligase activity
TK_RS06340	COG0303	'Molybdopterin
TK_RS06350	COG0693	protein deglycase activity
TK_RS06355	COG1522	sequence-specific DNA binding
TK_RS06360	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
TK_RS06390	COG0534	Mate efflux family protein
TK_RS06395	COG0534	Mate efflux family protein
TK_RS06410	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
TK_RS06410	COG0574	Belongs to the PEP-utilizing enzyme family
TK_RS06445	COG0446	pyridine nucleotide-disulphide oxidoreductase
TK_RS06485	COG0105	UTP biosynthetic process
TK_RS06525	COG0175	sulfate reduction
TK_RS06530	COG0330	HflC and HflK could
TK_RS06565	COG0438	transferase activity, transferring glycosyl groups
TK_RS06570	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
TK_RS06575	COG0493	'glutamate synthase
TK_RS06580	COG0543	2 iron, 2 sulfur cluster binding
TK_RS06640	COG1131	(ABC) transporter
TK_RS06650	COG1476	TRANSCRIPTIONal
TK_RS06845	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
TK_RS06850	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
TK_RS06885	COG2339	peptidase activity
TK_RS06915	COG0579	oxidoreductase
TK_RS06925	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
TK_RS06935	COG0584	glycerophosphoryl diester phosphodiesterase
TK_RS06940	COG0584	glycerophosphoryl diester phosphodiesterase
TK_RS06945	COG2211	Major facilitator Superfamily
TK_RS06950	COG2271	Major facilitator Superfamily
TK_RS06955	COG1073	alpha beta
TK_RS06965	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
TK_RS06975	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
TK_RS06980	COG0058	SHG alpha-glucan phosphorylase activity
TK_RS06990	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
TK_RS07020	COG0717	Belongs to the dCTP deaminase family
TK_RS07040	COG0081	regulation of translation
TK_RS07045	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
TK_RS07060	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
TK_RS07080	COG1458	PINc domain ribonuclease
TK_RS07100	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
TK_RS07110	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
TK_RS07115	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
TK_RS07125	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
TK_RS07130	COG0733	neurotransmitter:sodium symporter activity
TK_RS07140	COG0347	Belongs to the P(II) protein family
TK_RS07145	COG1543	Belongs to the glycosyl hydrolase 57 family
TK_RS07160	COG0864	Transcriptional regulator
TK_RS07175	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
TK_RS07180	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
TK_RS07185	COG0083	homoserine kinase activity
TK_RS07190	COG0527	aspartate kinase activity
TK_RS07195	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
TK_RS07225	COG1132	(ABC) transporter
TK_RS07270	COG0495	leucyl-tRNA aminoacylation
TK_RS07295	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
TK_RS07305	COG0142	geranyltranstransferase activity
TK_RS07315	COG1304	FMN binding
TK_RS07320	COG1794	racemase activity, acting on amino acids and derivatives
TK_RS07325	COG1058	Belongs to the CinA family
TK_RS07325	COG1546	Belongs to the CinA family
TK_RS07335	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
TK_RS07350	COG1355	regulation of microtubule-based process
TK_RS07355	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
TK_RS07360	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
TK_RS07380	COG0446	pyridine nucleotide-disulphide oxidoreductase
TK_RS07385	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
TK_RS07400	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
TK_RS07415	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
TK_RS07425	COG1522	sequence-specific DNA binding
TK_RS07445	COG1695	Transcriptional regulator
TK_RS07460	COG0052	Belongs to the universal ribosomal protein uS2 family
TK_RS07465	COG0148	phosphopyruvate hydratase activity
TK_RS07485	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
TK_RS07490	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
TK_RS07505	COG0202	RNA polymerase activity
TK_RS07515	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
TK_RS07520	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
TK_RS07535	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
TK_RS07545	COG1598	PFAM Uncharacterised protein family UPF0150
TK_RS07550	COG1028	Short-chain dehydrogenase reductase Sdr
TK_RS07560	COG1102	Psort location Cytoplasmic, score
TK_RS07585	COG0200	Binds to the 23S rRNA
TK_RS07590	COG1841	ribosomal large subunit assembly
TK_RS07595	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
TK_RS07600	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
TK_RS07615	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
TK_RS07620	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
TK_RS07630	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
TK_RS07640	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
TK_RS07645	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
TK_RS07650	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
TK_RS07665	COG0255	Belongs to the universal ribosomal protein uL29 family
TK_RS07670	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
TK_RS07680	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
TK_RS07685	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
TK_RS07690	COG0089	rRNA binding
TK_RS07700	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
TK_RS07730	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
TK_RS07740	COG0017	Asparaginyl-tRNA synthetase
TK_RS07745	COG0482	sulfurtransferase activity
TK_RS07760	COG1215	transferase activity, transferring glycosyl groups
TK_RS07770	COG0037	tRNA processing
TK_RS07775	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
TK_RS07780	COG0517	IMP dehydrogenase activity
TK_RS07780	COG0516	GMP reductase activity
TK_RS07785	COG0475	glutathione-regulated potassium exporter activity
TK_RS07790	COG0475	glutathione-regulated potassium exporter activity
TK_RS07795	COG2095	MarC family integral membrane protein
TK_RS07820	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
TK_RS07825	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
TK_RS07845	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
TK_RS07925	COG1131	(ABC) transporter
TK_RS07935	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
TK_RS07945	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
TK_RS07955	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
TK_RS07960	COG0569	domain protein
TK_RS07970	COG1269	ATP hydrolysis coupled proton transport
TK_RS07980	COG1390	Produces ATP from ADP in the presence of a proton gradient across the membrane
TK_RS07990	COG1436	Produces ATP from ADP in the presence of a proton gradient across the membrane
TK_RS07995	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
TK_RS08015	COG5278	phosphoserine phosphatase activity
TK_RS08015	COG0840	transmembrane signaling receptor activity
TK_RS08060	COG0430	RNA-3'-phosphate cyclase activity
TK_RS08095	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
TK_RS08105	COG5016	pyruvate
TK_RS08105	COG0511	ligase activity, forming carbon-carbon bonds
TK_RS08110	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
TK_RS08115	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
TK_RS08115	COG0517	IMP dehydrogenase activity
TK_RS08150	COG1185	polyribonucleotide nucleotidyltransferase activity
TK_RS08155	COG1185	polyribonucleotide nucleotidyltransferase activity
TK_RS08170	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
TK_RS08200	COG1013	pyruvate-flavodoxin oxidoreductase activity
TK_RS08235	COG1335	isochorismatase
TK_RS08245	COG2050	protein possibly involved in aromatic compounds catabolism
TK_RS08245	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
TK_RS08255	COG1695	Transcriptional regulator
TK_RS08265	COG0252	asparaginase activity
TK_RS08280	COG2095	MarC family integral membrane protein
TK_RS08345	COG2890	protein-(glutamine-N5) methyltransferase activity
TK_RS08365	COG1028	Short-chain dehydrogenase reductase Sdr
TK_RS08400	COG0493	'glutamate synthase
TK_RS08400	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
TK_RS08405	COG0543	2 iron, 2 sulfur cluster binding
TK_RS08415	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
TK_RS08435	COG1404	Belongs to the peptidase S8 family
TK_RS08455	COG2151	metal-sulfur cluster biosynthetic enzyme
TK_RS08460	COG1141	Ferredoxin
TK_RS08555	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
TK_RS08560	COG2244	polysaccharide biosynthetic process
TK_RS08585	COG1216	Glycosyl transferase, family 2
TK_RS08585	COG0463	Glycosyl transferase, family 2
TK_RS08600	COG0463	Glycosyl transferase, family 2
TK_RS08610	COG1442	glycosyl transferase family 8
TK_RS08610	COG1216	Glycosyl transferase, family 2
TK_RS08655	COG0438	transferase activity, transferring glycosyl groups
TK_RS08665	COG0438	transferase activity, transferring glycosyl groups
TK_RS08680	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
TK_RS08680	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
TK_RS08685	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
TK_RS08690	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
TK_RS08775	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
TK_RS08785	COG0444	Belongs to the ABC transporter superfamily
TK_RS08795	COG0601	transmembrane transport
TK_RS08850	COG0297	glycogen (starch) synthase activity
TK_RS08855	COG1378	Sugar-specific transcriptional regulator TrmB
TK_RS08875	COG3833	ABC-type maltose transport systems, permease component
TK_RS08885	COG3842	ATPase activity
TK_RS08895	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
TK_RS08900	COG1234	tRNA 3'-trailer cleavage
TK_RS08905	COG1297	OPT oligopeptide transporter protein
TK_RS08915	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
TK_RS08935	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
TK_RS08955	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
TK_RS08970	COG0697	spore germination
TK_RS08990	COG0174	glutamine synthetase
TK_RS09010	COG4608	Belongs to the ABC transporter superfamily
TK_RS09015	COG0444	Belongs to the ABC transporter superfamily
TK_RS09020	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TK_RS09025	COG0601	transmembrane transport
TK_RS09035	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
TK_RS09040	COG0543	2 iron, 2 sulfur cluster binding
TK_RS09055	COG1449	Belongs to the glycosyl hydrolase 57 family
TK_RS09075	COG0569	domain protein
TK_RS09075	COG0475	glutathione-regulated potassium exporter activity
TK_RS09110	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TK_RS09115	COG0037	tRNA processing
TK_RS09120	COG1373	ATPase (AAA superfamily
TK_RS09145	COG2723	6-phospho-beta-galactosidase activity
TK_RS09150	COG1085	galactose-1-phosphate uridylyltransferase
TK_RS09165	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
TK_RS09190	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
TK_RS09210	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
TK_RS09225	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
TK_RS09240	COG0714	Associated with various cellular activities
TK_RS09260	COG1047	Peptidyl-prolyl cis-trans
TK_RS09295	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
TK_RS09305	COG1136	(ABC) transporter
TK_RS09305	COG0577	efflux transmembrane transporter activity
TK_RS09315	COG4174	ABC transporter (Permease)
TK_RS09325	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
TK_RS09325	COG0116	Belongs to the methyltransferase superfamily
TK_RS09340	COG0573	inorganic phosphate transmembrane transporter activity
TK_RS09350	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
TK_RS09360	COG0704	Plays a role in the regulation of phosphate uptake
TK_RS09370	COG0179	Fumarylacetoacetate (FAA) hydrolase
TK_RS09400	COG1234	tRNA 3'-trailer cleavage
TK_RS09415	COG0640	Transcriptional regulator
TK_RS09440	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
TK_RS09440	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
TK_RS09460	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
TK_RS09460	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
TK_RS09465	COG0402	S-adenosylhomocysteine deaminase activity
TK_RS09475	COG2379	hydroxypyruvate reductase
TK_RS09485	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
TK_RS09500	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
TK_RS09510	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
TK_RS09555	COG0095	Lipoate-protein ligase
TK_RS09565	COG0463	Glycosyl transferase, family 2
TK_RS09570	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
TK_RS09675	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
TK_RS09680	COG2264	protein methyltransferase activity
TK_RS09715	COG0668	transmembrane transport
TK_RS09785	COG0218	Necessary for normal cell division and for the maintenance of normal septation
TK_RS09790	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
TK_RS09800	COG0109	protoheme IX farnesyltransferase activity
TK_RS09845	COG0281	malic enzyme
TK_RS09860	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
TK_RS09870	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
TK_RS09880	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
TK_RS09910	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
TK_RS09915	COG0306	phosphate transporter
TK_RS09930	COG0674	pyruvate-flavodoxin oxidoreductase activity
TK_RS09935	COG1013	pyruvate-flavodoxin oxidoreductase activity
TK_RS09940	COG1144	Oxidoreductase
TK_RS09940	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
TK_RS09945	COG0674	pyruvate-flavodoxin oxidoreductase activity
TK_RS09950	COG1013	pyruvate-flavodoxin oxidoreductase activity
TK_RS09980	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
TK_RS09995	COG0309	Hydrogenase expression formation protein (HypE)
TK_RS10015	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
TK_RS10025	COG1528	Iron-storage protein
TK_RS10030	COG0409	Hydrogenase expression formation protein
TK_RS10035	COG0298	carbon dioxide binding
TK_RS10040	COG0746	molybdenum cofactor guanylyltransferase activity
TK_RS10065	COG0489	protein tyrosine kinase activity
TK_RS10070	COG0375	protein maturation
TK_RS10075	COG1230	cation diffusion facilitator family transporter
TK_RS10120	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TK_RS10125	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
TK_RS10130	COG0489	protein tyrosine kinase activity
TK_RS10155	COG1131	(ABC) transporter
TK_RS10170	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
TK_RS10180	COG1254	Belongs to the acylphosphatase family
TK_RS10190	COG1628	Protein of unknown function DUF99
TK_RS10195	COG0589	response to stress
TK_RS10200	COG0404	The glycine cleavage system catalyzes the degradation of glycine
TK_RS10210	COG0681	Belongs to the peptidase S26 family
TK_RS10235	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
TK_RS10270	COG0823	Involved in the tonB-independent uptake of proteins
TK_RS10270	COG4946	Tricorn protease homolog
TK_RS10270	COG1506	peptidase
TK_RS10290	COG1131	(ABC) transporter
TK_RS10320	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
TK_RS10330	COG0306	phosphate transporter
TK_RS10345	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TK_RS10395	COG0493	'glutamate synthase
TK_RS10400	COG0437	4 iron, 4 sulfur cluster binding
TK_RS10405	COG3383	formate dehydrogenase (NAD+) activity
TK_RS10410	COG0437	4 iron, 4 sulfur cluster binding
TK_RS10415	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
TK_RS10415	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
TK_RS10420	COG2116	formate transmembrane transporter activity
TK_RS10430	COG2212	antiporter activity
TK_RS10435	COG1320	monovalent cation:proton antiporter activity
TK_RS10460	COG0651	ATP synthesis coupled electron transport
TK_RS10470	COG3260	NADH ubiquinone oxidoreductase 20
TK_RS10475	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
TK_RS10475	COG3261	NADH dehydrogenase
TK_RS10485	COG0650	Formate hydrogenlyase subunit 4
TK_RS10525	COG0492	ferredoxin-NADP+ reductase activity
TK_RS10530	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
TK_RS10545	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
TK_RS10555	COG0148	phosphopyruvate hydratase activity
TK_RS10580	COG1522	sequence-specific DNA binding
TK_RS10605	COG0314	molybdopterin synthase activity
TK_RS10650	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
TK_RS10660	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
TK_RS10690	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
TK_RS10715	COG1522	sequence-specific DNA binding
TK_RS10730	COG2894	cell division
TK_RS10735	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
TK_RS10755	COG1757	Na H antiporter
TK_RS10765	COG1573	uracil-dna glycosylase
TK_RS10775	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
TK_RS10785	COG0840	transmembrane signaling receptor activity
TK_RS10795	COG1380	Effector of murein hydrolase LrgA
TK_RS10800	COG1346	cytolysis
TK_RS10855	COG0535	radical SAM domain protein
TK_RS10860	COG1131	(ABC) transporter
TK_RS10875	COG1980	fructose-bisphosphate aldolase activity
TK_RS10900	COG0312	modulator of DNA gyrase
TK_RS10950	COG0434	BtpA family
TK_RS10980	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
TK_RS11030	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
TK_RS11035	COG0540	Belongs to the ATCase OTCase family
TK_RS11070	COG2078	PFAM AMMECR1 domain protein
TK_RS11070	COG3885	ferrous iron binding
TK_RS11100	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TK_RS11110	COG0419	ATPase involved in DNA repair
TK_RS11110	COG0419	ATPase involved in DNA repair
TK_RS11120	COG0433	COG0433 Predicted ATPase
TK_RS11125	COG0456	acetyltransferase
TK_RS11140	COG0156	8-amino-7-oxononanoate synthase activity
TK_RS11145	COG0305	Participates in initiation and elongation during chromosome replication
TK_RS11145	COG1372	Participates in initiation and elongation during chromosome replication
TK_RS11150	COG2255	four-way junction helicase activity
TK_RS11180	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
TK_RS11190	COG1530	ribonuclease E activity
TK_RS11210	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
TK_RS11215	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
TK_RS11270	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
TK_RS11275	COG2226	methyltransferase
TK_RS11310	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
TK_RS11325	COG2271	Major facilitator Superfamily
TK_RS11330	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
TK_RS11340	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
TK_RS11345	COG0546	phosphoglycolate phosphatase activity
TK_RS11355	COG2131	deaminase
TK_RS11360	COG0501	Belongs to the peptidase M48B family
TK_RS11375	COG0167	dihydroorotate dehydrogenase activity
TK_RS11390	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
TK_RS11420	COG2119	membrane
TK_RS11425	COG0436	Aminotransferase
TK_RS11440	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
TK_RS11445	COG1192	Involved in chromosome partitioning
TK_RS11455	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
TK_RS11455	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
TK_RS11465	COG0284	orotidine-5'-phosphate decarboxylase activity
TK_RS11480	COG1213	nucleotidyl transferase
TK_RS11480	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
TK_RS11490	COG1131	(ABC) transporter
TK_RS11535	COG1850	ribulose-bisphosphate carboxylase activity
TK_RS11555	COG1851	Uncharacterised protein family (UPF0128)
TK_RS11595	COG0585	pseudouridine synthase activity
TK_RS11605	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
TK_RS11605	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
TK_RS11630	COG0641	radical SAM
TK_RS11635	COG1132	(ABC) transporter
TK_RS11745	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
TK_RS11750	COG2813	Specifically methylates the guanine in position
TK_RS11790	COG0287	Prephenate dehydrogenase
TK_RS11790	COG1605	Chorismate mutase
TK_RS11825	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex