locus-tag	class	description
A3L08_RS00030	COG1832	CoA-binding protein
A3L08_RS00060	COG1851	Uncharacterised protein family (UPF0128)
A3L08_RS00080	COG1435	thymidine kinase activity
A3L08_RS00085	COG1850	ribulose-bisphosphate carboxylase activity
A3L08_RS00130	COG1131	(ABC) transporter
A3L08_RS00140	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
A3L08_RS00140	COG1213	nucleotidyl transferase
A3L08_RS00155	COG0284	orotidine-5'-phosphate decarboxylase activity
A3L08_RS00165	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
A3L08_RS00165	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
A3L08_RS00175	COG1192	Involved in chromosome partitioning
A3L08_RS00180	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
A3L08_RS00195	COG0436	Aminotransferase
A3L08_RS00200	COG2119	membrane
A3L08_RS00240	COG1476	TRANSCRIPTIONal
A3L08_RS00250	COG1131	(ABC) transporter
A3L08_RS00285	COG4608	Belongs to the ABC transporter superfamily
A3L08_RS00290	COG0444	Belongs to the ABC transporter superfamily
A3L08_RS00295	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A3L08_RS00300	COG0601	transmembrane transport
A3L08_RS00305	COG0747	negative chemotaxis
A3L08_RS00335	COG0543	2 iron, 2 sulfur cluster binding
A3L08_RS00350	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
A3L08_RS00365	COG0509	glycine decarboxylation via glycine cleavage system
A3L08_RS00370	COG1863	multisubunit Na H antiporter MnhE subunit
A3L08_RS00375	COG2212	antiporter activity
A3L08_RS00380	COG1320	monovalent cation:proton antiporter activity
A3L08_RS00405	COG0651	ATP synthesis coupled electron transport
A3L08_RS00430	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
A3L08_RS00455	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
A3L08_RS00460	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A3L08_RS00535	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
A3L08_RS00555	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
A3L08_RS00560	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A3L08_RS00565	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
A3L08_RS00575	COG1765	OsmC-like protein
A3L08_RS00580	COG2095	MarC family integral membrane protein
A3L08_RS00610	COG0693	protein deglycase activity
A3L08_RS00615	COG1522	sequence-specific DNA binding
A3L08_RS00620	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
A3L08_RS00635	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A3L08_RS00650	COG2814	Major facilitator Superfamily
A3L08_RS00670	COG0528	UMP kinase activity
A3L08_RS00675	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A3L08_RS00700	COG0167	dihydroorotate dehydrogenase activity
A3L08_RS00705	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
A3L08_RS00735	COG2151	metal-sulfur cluster biosynthetic enzyme
A3L08_RS00740	COG1141	Ferredoxin
A3L08_RS00765	COG0493	'glutamate synthase
A3L08_RS00770	COG0543	2 iron, 2 sulfur cluster binding
A3L08_RS00810	COG0501	Belongs to the peptidase M48B family
A3L08_RS00815	COG2131	deaminase
A3L08_RS00825	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A3L08_RS00840	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
A3L08_RS00845	COG2271	Major facilitator Superfamily
A3L08_RS00860	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
A3L08_RS00870	COG1446	asparaginase
A3L08_RS00875	COG0704	Plays a role in the regulation of phosphate uptake
A3L08_RS00895	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
A3L08_RS00965	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
A3L08_RS00980	COG2255	four-way junction helicase activity
A3L08_RS00985	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
A3L08_RS00990	COG0156	8-amino-7-oxononanoate synthase activity
A3L08_RS01000	COG0456	acetyltransferase
A3L08_RS01000	COG1214	PFAM Peptidase M22, glycoprotease
A3L08_RS01010	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
A3L08_RS01015	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
A3L08_RS01035	COG2078	PFAM AMMECR1 domain protein
A3L08_RS01035	COG3885	ferrous iron binding
A3L08_RS01045	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
A3L08_RS01050	COG0442	prolyl-tRNA aminoacylation
A3L08_RS01085	COG0540	Belongs to the ATCase OTCase family
A3L08_RS01090	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
A3L08_RS01105	COG0237	dephospho-CoA kinase activity
A3L08_RS01125	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
A3L08_RS01155	COG0434	BtpA family
A3L08_RS01190	COG0312	modulator of DNA gyrase
A3L08_RS01225	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A3L08_RS01240	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
A3L08_RS01250	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
A3L08_RS01260	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
A3L08_RS01265	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
A3L08_RS01270	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
A3L08_RS01305	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
A3L08_RS01310	COG0306	phosphate transporter
A3L08_RS01325	COG0674	pyruvate-flavodoxin oxidoreductase activity
A3L08_RS01330	COG1013	pyruvate-flavodoxin oxidoreductase activity
A3L08_RS01340	COG0674	pyruvate-flavodoxin oxidoreductase activity
A3L08_RS01345	COG1013	pyruvate-flavodoxin oxidoreductase activity
A3L08_RS01350	COG0489	protein tyrosine kinase activity
A3L08_RS01375	COG1131	(ABC) transporter
A3L08_RS01390	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A3L08_RS01400	COG1254	Belongs to the acylphosphatase family
A3L08_RS01410	COG1628	Protein of unknown function DUF99
A3L08_RS01420	COG0404	The glycine cleavage system catalyzes the degradation of glycine
A3L08_RS01465	COG1233	COG1233 Phytoene dehydrogenase and related
A3L08_RS01475	COG1980	fructose-bisphosphate aldolase activity
A3L08_RS01490	COG1522	sequence-specific DNA binding
A3L08_RS01505	COG2894	cell division
A3L08_RS01510	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
A3L08_RS01530	COG1757	Na H antiporter
A3L08_RS01535	COG1573	uracil-dna glycosylase
A3L08_RS01545	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
A3L08_RS01560	COG1380	Effector of murein hydrolase LrgA
A3L08_RS01565	COG1346	cytolysis
A3L08_RS01585	COG0235	Class ii aldolase
A3L08_RS01595	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
A3L08_RS01645	COG0095	Lipoate-protein ligase
A3L08_RS01650	COG0681	Belongs to the peptidase S26 family
A3L08_RS01675	COG0823	Involved in the tonB-independent uptake of proteins
A3L08_RS01675	COG1506	peptidase
A3L08_RS01675	COG4946	Tricorn protease homolog
A3L08_RS01720	COG0306	phosphate transporter
A3L08_RS01735	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
A3L08_RS01745	COG1863	multisubunit Na H antiporter MnhE subunit
A3L08_RS01750	COG2212	antiporter activity
A3L08_RS01755	COG1320	monovalent cation:proton antiporter activity
A3L08_RS01780	COG0651	ATP synthesis coupled electron transport
A3L08_RS01790	COG3260	NADH ubiquinone oxidoreductase 20
A3L08_RS01795	COG3261	NADH dehydrogenase
A3L08_RS01795	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
A3L08_RS01805	COG0650	Formate hydrogenlyase subunit 4
A3L08_RS01850	COG0492	ferredoxin-NADP+ reductase activity
A3L08_RS01855	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
A3L08_RS01885	COG0148	phosphopyruvate hydratase activity
A3L08_RS01905	COG1522	sequence-specific DNA binding
A3L08_RS01910	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
A3L08_RS01930	COG0314	molybdopterin synthase activity
A3L08_RS01940	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
A3L08_RS01965	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
A3L08_RS01965	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
A3L08_RS01975	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
A3L08_RS01985	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
A3L08_RS02040	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
A3L08_RS02050	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
A3L08_RS02065	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
A3L08_RS02070	COG0402	S-adenosylhomocysteine deaminase activity
A3L08_RS02075	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
A3L08_RS02075	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
A3L08_RS02100	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
A3L08_RS02100	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
A3L08_RS02120	COG0640	Transcriptional regulator
A3L08_RS02140	COG0179	Fumarylacetoacetate (FAA) hydrolase
A3L08_RS02155	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
A3L08_RS02155	COG0116	Belongs to the methyltransferase superfamily
A3L08_RS02160	COG0601	transmembrane transport
A3L08_RS02170	COG1160	GTP binding
A3L08_RS02205	COG1047	Peptidyl-prolyl cis-trans
A3L08_RS02225	COG0714	Associated with various cellular activities
A3L08_RS02245	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
A3L08_RS02255	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A3L08_RS02300	COG0037	tRNA processing
A3L08_RS02305	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A3L08_RS02310	COG0463	Glycosyl transferase, family 2
A3L08_RS02310	COG1216	Glycosyl transferase, family 2
A3L08_RS02315	COG1210	Utp--glucose-1-phosphate uridylyltransferase
A3L08_RS02320	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
A3L08_RS02345	COG0730	response to heat
A3L08_RS02350	COG0529	Catalyzes the synthesis of activated sulfate
A3L08_RS02365	COG2046	Belongs to the sulfate adenylyltransferase family
A3L08_RS02380	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
A3L08_RS02390	COG4651	solute:proton antiporter activity
A3L08_RS02390	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
A3L08_RS02415	COG1449	Belongs to the glycosyl hydrolase 57 family
A3L08_RS02425	COG0037	tRNA processing
A3L08_RS02430	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
A3L08_RS02435	COG0517	IMP dehydrogenase activity
A3L08_RS02440	COG0475	glutathione-regulated potassium exporter activity
A3L08_RS02445	COG0475	glutathione-regulated potassium exporter activity
A3L08_RS02460	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
A3L08_RS02465	COG1115	amino acid carrier protein
A3L08_RS02475	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
A3L08_RS02495	COG1131	(ABC) transporter
A3L08_RS02505	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
A3L08_RS02555	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
A3L08_RS02565	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
A3L08_RS02570	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
A3L08_RS02575	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
A3L08_RS02580	COG0569	domain protein
A3L08_RS02590	COG1269	ATP hydrolysis coupled proton transport
A3L08_RS02600	COG1390	Produces ATP from ADP in the presence of a proton gradient across the membrane
A3L08_RS02615	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
A3L08_RS02630	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
A3L08_RS02645	COG0482	sulfurtransferase activity
A3L08_RS02660	COG0543	2 iron, 2 sulfur cluster binding
A3L08_RS02665	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
A3L08_RS02675	COG0601	transmembrane transport
A3L08_RS02680	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A3L08_RS02685	COG0444	Belongs to the ABC transporter superfamily
A3L08_RS02690	COG4608	Belongs to the ABC transporter superfamily
A3L08_RS02710	COG0174	glutamine synthetase
A3L08_RS02750	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
A3L08_RS02770	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
A3L08_RS02785	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A3L08_RS02795	COG1297	OPT oligopeptide transporter protein
A3L08_RS02800	COG1234	tRNA 3'-trailer cleavage
A3L08_RS02805	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
A3L08_RS02815	COG3842	ATPase activity
A3L08_RS02825	COG3833	ABC-type maltose transport systems, permease component
A3L08_RS02830	COG1175	transmembrane transport
A3L08_RS02845	COG1378	Sugar-specific transcriptional regulator TrmB
A3L08_RS02850	COG0297	glycogen (starch) synthase activity
A3L08_RS02895	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
A3L08_RS02910	COG0493	'glutamate synthase
A3L08_RS02910	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
A3L08_RS02915	COG2414	aldehyde ferredoxin oxidoreductase
A3L08_RS02920	COG2104	thiamine diphosphate biosynthetic process
A3L08_RS02940	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
A3L08_RS02960	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A3L08_RS02970	COG0647	UMP catabolic process
A3L08_RS02980	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A3L08_RS03005	COG0714	Associated with various cellular activities
A3L08_RS03115	COG0438	transferase activity, transferring glycosyl groups
A3L08_RS03125	COG0463	Glycosyl transferase, family 2
A3L08_RS03135	COG1216	Glycosyl transferase, family 2
A3L08_RS03205	COG0517	IMP dehydrogenase activity
A3L08_RS03205	COG0516	GMP reductase activity
A3L08_RS03210	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
A3L08_RS03220	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
A3L08_RS03230	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
A3L08_RS03235	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
A3L08_RS03245	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
A3L08_RS03250	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
A3L08_RS03255	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
A3L08_RS03260	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
A3L08_RS03265	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
A3L08_RS03270	COG0151	Belongs to the GarS family
A3L08_RS03285	COG0047	phosphoribosylformylglycinamidine synthase activity
A3L08_RS03290	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
A3L08_RS03300	COG0519	Catalyzes the synthesis of GMP from XMP
A3L08_RS03300	COG0518	GMP synthase (glutamine-hydrolyzing) activity
A3L08_RS03305	COG0518	GMP synthase (glutamine-hydrolyzing) activity
A3L08_RS03305	COG0519	Catalyzes the synthesis of GMP from XMP
A3L08_RS03370	COG2890	protein-(glutamine-N5) methyltransferase activity
A3L08_RS03460	COG2234	aminopeptidase activity
A3L08_RS03500	COG1695	Transcriptional regulator
A3L08_RS03530	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
A3L08_RS03535	COG2264	protein methyltransferase activity
A3L08_RS03540	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
A3L08_RS03540	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
A3L08_RS03545	COG0668	transmembrane transport
A3L08_RS03600	COG0218	Necessary for normal cell division and for the maintenance of normal septation
A3L08_RS03605	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
A3L08_RS03615	COG0109	protoheme IX farnesyltransferase activity
A3L08_RS03665	COG2252	PERMEase
A3L08_RS03675	COG1177	transmembrane transport
A3L08_RS03705	COG0011	TIGRFAM Protein of
A3L08_RS03710	COG2078	PFAM AMMECR1 domain protein
A3L08_RS03715	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
A3L08_RS03715	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
A3L08_RS03730	COG0417	DNA replication proofreading
A3L08_RS03765	COG1185	polyribonucleotide nucleotidyltransferase activity
A3L08_RS03780	COG0252	asparaginase activity
A3L08_RS03785	COG2814	Major facilitator Superfamily
A3L08_RS03790	COG1695	Transcriptional regulator
A3L08_RS03795	COG2050	protein possibly involved in aromatic compounds catabolism
A3L08_RS03795	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
A3L08_RS03805	COG1335	isochorismatase
A3L08_RS03825	COG1013	pyruvate-flavodoxin oxidoreductase activity
A3L08_RS03855	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
A3L08_RS03870	COG1185	polyribonucleotide nucleotidyltransferase activity
A3L08_RS03875	COG1185	polyribonucleotide nucleotidyltransferase activity
A3L08_RS03905	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
A3L08_RS03905	COG0517	IMP dehydrogenase activity
A3L08_RS03910	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
A3L08_RS03915	COG5016	pyruvate
A3L08_RS03915	COG0511	ligase activity, forming carbon-carbon bonds
A3L08_RS03925	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
A3L08_RS03935	COG0305	Participates in initiation and elongation during chromosome replication
A3L08_RS03935	COG1372	Participates in initiation and elongation during chromosome replication
A3L08_RS03960	COG0430	RNA-3'-phosphate cyclase activity
A3L08_RS04010	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
A3L08_RS04015	COG0017	Asparaginyl-tRNA synthetase
A3L08_RS04025	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
A3L08_RS04050	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
A3L08_RS04060	COG0089	rRNA binding
A3L08_RS04065	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
A3L08_RS04070	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
A3L08_RS04075	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
A3L08_RS04080	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
A3L08_RS04085	COG0255	Belongs to the universal ribosomal protein uL29 family
A3L08_RS04100	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
A3L08_RS04105	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
A3L08_RS04110	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
A3L08_RS04120	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
A3L08_RS04130	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
A3L08_RS04135	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
A3L08_RS04150	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
A3L08_RS04155	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
A3L08_RS04160	COG1841	ribosomal large subunit assembly
A3L08_RS04165	COG0200	Binds to the 23S rRNA
A3L08_RS04190	COG1102	Psort location Cytoplasmic, score
A3L08_RS04200	COG1028	Short-chain dehydrogenase reductase Sdr
A3L08_RS04205	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
A3L08_RS04210	COG2813	Specifically methylates the guanine in position
A3L08_RS04220	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
A3L08_RS04225	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
A3L08_RS04235	COG0202	RNA polymerase activity
A3L08_RS04250	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
A3L08_RS04255	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
A3L08_RS04280	COG0052	Belongs to the universal ribosomal protein uS2 family
A3L08_RS04315	COG1522	sequence-specific DNA binding
A3L08_RS04325	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
A3L08_RS04340	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
A3L08_RS04355	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
A3L08_RS04360	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
A3L08_RS04375	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
A3L08_RS04380	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
A3L08_RS04385	COG1355	regulation of microtubule-based process
A3L08_RS04390	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
A3L08_RS04415	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
A3L08_RS04420	COG1304	FMN binding
A3L08_RS04435	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A3L08_RS04435	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A3L08_RS04445	COG0495	leucyl-tRNA aminoacylation
A3L08_RS04455	COG0006	proline dipeptidase activity
A3L08_RS04475	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
A3L08_RS04495	COG0864	Transcriptional regulator
A3L08_RS04515	COG0347	Belongs to the P(II) protein family
A3L08_RS04525	COG0733	neurotransmitter:sodium symporter activity
A3L08_RS04530	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
A3L08_RS04540	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
A3L08_RS04545	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
A3L08_RS04560	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
A3L08_RS04575	COG1473	amidohydrolase
A3L08_RS04585	COG0585	pseudouridine synthase activity
A3L08_RS04600	COG0017	Asparaginyl-tRNA synthetase
A3L08_RS04610	COG1418	mRNA catabolic process
A3L08_RS04620	COG1011	Hydrolase
A3L08_RS04630	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
A3L08_RS04655	COG1110	DNA topoisomerase II activity
A3L08_RS04710	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
A3L08_RS04755	COG0644	oxidoreductase
A3L08_RS04760	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
A3L08_RS04775	COG1458	PINc domain ribonuclease
A3L08_RS04795	COG2358	TRAP transporter, solute receptor (TAXI family
A3L08_RS04805	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
A3L08_RS04820	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
A3L08_RS04825	COG0081	regulation of translation
A3L08_RS04845	COG0717	Belongs to the dCTP deaminase family
A3L08_RS04875	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
A3L08_RS04885	COG0058	SHG alpha-glucan phosphorylase activity
A3L08_RS04890	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
A3L08_RS04905	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
A3L08_RS04930	COG2211	Major facilitator Superfamily
A3L08_RS04935	COG0584	glycerophosphoryl diester phosphodiesterase
A3L08_RS04940	COG0584	glycerophosphoryl diester phosphodiesterase
A3L08_RS04955	COG0579	oxidoreductase
A3L08_RS05005	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
A3L08_RS05010	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
A3L08_RS05040	COG0085	RNA polymerase activity
A3L08_RS05045	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
A3L08_RS05050	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
A3L08_RS05070	COG0049	tRNA binding
A3L08_RS05075	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
A3L08_RS05120	COG0436	Aminotransferase
A3L08_RS05145	COG1185	polyribonucleotide nucleotidyltransferase activity
A3L08_RS05160	COG0310	cobalt ion transport
A3L08_RS05175	COG1122	ATPase activity
A3L08_RS05195	COG2140	Oxalate decarboxylase
A3L08_RS05215	COG1234	tRNA 3'-trailer cleavage
A3L08_RS05225	COG1230	cation diffusion facilitator family transporter
A3L08_RS05240	COG0798	PFAM Bile acid sodium symporter
A3L08_RS05250	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
A3L08_RS05255	COG0798	PFAM Bile acid sodium symporter
A3L08_RS05300	COG2414	aldehyde ferredoxin oxidoreductase
A3L08_RS05310	COG0489	protein tyrosine kinase activity
A3L08_RS05340	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
A3L08_RS05345	COG0298	carbon dioxide binding
A3L08_RS05350	COG0409	Hydrogenase expression formation protein
A3L08_RS05355	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
A3L08_RS05370	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
A3L08_RS05390	COG0446	pyridine nucleotide-disulphide oxidoreductase
A3L08_RS05405	COG1404	Belongs to the peptidase S8 family
A3L08_RS05420	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
A3L08_RS05420	COG0574	Belongs to the PEP-utilizing enzyme family
A3L08_RS05425	COG0534	Mate efflux family protein
A3L08_RS05430	COG0534	Mate efflux family protein
A3L08_RS05435	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
A3L08_RS05460	COG0504	CTP synthase activity
A3L08_RS05480	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
A3L08_RS05490	COG1968	undecaprenyl-diphosphatase activity
A3L08_RS05505	COG0516	GMP reductase activity
A3L08_RS05505	COG0517	IMP dehydrogenase activity
A3L08_RS05515	COG0024	Methionine aminopeptidase
A3L08_RS05520	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
A3L08_RS05525	COG1122	ATPase activity
A3L08_RS05565	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
A3L08_RS05580	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
A3L08_RS05625	COG0628	permease
A3L08_RS05630	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
A3L08_RS05655	COG1131	(ABC) transporter
A3L08_RS05665	COG0556	nucleotide-excision repair
A3L08_RS05670	COG0101	tRNA pseudouridine synthase activity
A3L08_RS05685	COG1063	alcohol dehydrogenase
A3L08_RS05690	COG2894	cell division
A3L08_RS05705	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
A3L08_RS05710	COG0252	asparaginase activity
A3L08_RS05740	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
A3L08_RS05750	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
A3L08_RS05780	COG0438	transferase activity, transferring glycosyl groups
A3L08_RS05790	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
A3L08_RS05810	COG0475	glutathione-regulated potassium exporter activity
A3L08_RS05820	COG0010	Belongs to the arginase family
A3L08_RS05860	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
A3L08_RS05865	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
A3L08_RS05870	COG1757	Na H antiporter
A3L08_RS05880	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
A3L08_RS05895	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
A3L08_RS05900	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
A3L08_RS05905	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
A3L08_RS05925	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
A3L08_RS05930	COG0746	molybdenum cofactor guanylyltransferase activity
A3L08_RS05945	COG1492	cobalamin metabolic process
A3L08_RS05950	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
A3L08_RS05960	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A3L08_RS05965	COG0656	L-ascorbic acid biosynthetic process
A3L08_RS05980	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A3L08_RS05980	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A3L08_RS06000	COG0359	binds to the 23S rRNA
A3L08_RS06000	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
A3L08_RS06065	COG0602	queuosine metabolic process
A3L08_RS06070	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
A3L08_RS06105	COG1028	Short-chain dehydrogenase reductase Sdr
A3L08_RS06110	COG1881	PFAM PEBP family protein
A3L08_RS06170	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A3L08_RS06175	COG0649	NAD binding
A3L08_RS06180	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A3L08_RS06185	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A3L08_RS06190	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
A3L08_RS06195	COG0651	ATP synthesis coupled electron transport
A3L08_RS06200	COG0651	ATP synthesis coupled electron transport
A3L08_RS06205	COG1006	Multisubunit Na H antiporter MnhC subunit
A3L08_RS06210	COG2111	Na H antiporter
A3L08_RS06210	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
A3L08_RS06220	COG1320	monovalent cation:proton antiporter activity
A3L08_RS06225	COG2212	antiporter activity
A3L08_RS06230	COG1863	multisubunit Na H antiporter MnhE subunit
A3L08_RS06240	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
A3L08_RS06265	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
A3L08_RS06285	COG0018	arginyl-trna synthetase
A3L08_RS06290	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A3L08_RS06315	COG0546	phosphoglycolate phosphatase activity
A3L08_RS06315	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
A3L08_RS06380	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
A3L08_RS06400	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A3L08_RS06400	COG0301	tRNA thio-modification
A3L08_RS06405	COG1836	PFAM Integral membrane protein DUF92
A3L08_RS06410	COG1522	sequence-specific DNA binding
A3L08_RS06420	COG0640	Transcriptional regulator
A3L08_RS06430	COG0251	oxidation-reduction process
A3L08_RS06445	COG0396	ATPase activity
A3L08_RS06450	COG0719	Fe-S assembly protein
A3L08_RS06485	COG1941	NADH ubiquinone oxidoreductase 20 kDa subunit
A3L08_RS06500	COG0243	molybdopterin cofactor binding
A3L08_RS06510	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
A3L08_RS06515	COG0651	ATP synthesis coupled electron transport
A3L08_RS06520	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
A3L08_RS06525	COG3261	NADH dehydrogenase
A3L08_RS06525	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
A3L08_RS06530	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A3L08_RS06535	COG3260	NADH ubiquinone oxidoreductase 20
A3L08_RS06565	COG1006	Multisubunit Na H antiporter MnhC subunit
A3L08_RS06575	COG0651	ATP synthesis coupled electron transport
A3L08_RS06590	COG0437	4 iron, 4 sulfur cluster binding
A3L08_RS06600	COG3259	Nickel-dependent hydrogenase
A3L08_RS06605	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
A3L08_RS06615	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
A3L08_RS06620	COG1476	TRANSCRIPTIONal
A3L08_RS06665	COG1812	S-adenosylmethionine synthetase (AdoMet synthetase)
A3L08_RS06675	COG1618	nucleotide phosphatase activity, acting on free nucleotides
A3L08_RS06685	COG0436	Aminotransferase
A3L08_RS06690	COG2192	nodulation
A3L08_RS06695	COG0442	prolyl-tRNA aminoacylation
A3L08_RS06700	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
A3L08_RS06710	COG0730	response to heat
A3L08_RS06720	COG0730	response to heat
A3L08_RS06740	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A3L08_RS06740	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A3L08_RS06745	COG0720	synthase
A3L08_RS06760	COG1013	pyruvate-flavodoxin oxidoreductase activity
A3L08_RS06765	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
A3L08_RS06765	COG0674	pyruvate-flavodoxin oxidoreductase activity
A3L08_RS06775	COG1013	pyruvate-flavodoxin oxidoreductase activity
A3L08_RS06780	COG0674	pyruvate-flavodoxin oxidoreductase activity
A3L08_RS06780	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
A3L08_RS06795	COG2001	Belongs to the MraZ family
A3L08_RS06805	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
A3L08_RS06815	COG0552	protein localization to endoplasmic reticulum
A3L08_RS06825	COG1744	ABC transporter substrate-binding protein PnrA-like
A3L08_RS06830	COG3845	ABC transporter
A3L08_RS06835	COG4603	Belongs to the binding-protein-dependent transport system permease family
A3L08_RS06840	COG1079	Belongs to the binding-protein-dependent transport system permease family
A3L08_RS06865	COG0215	cysteine-tRNA ligase activity
A3L08_RS06870	COG1047	Peptidyl-prolyl cis-trans
A3L08_RS06890	COG0351	phosphomethylpyrimidine kinase
A3L08_RS06890	COG0352	thiamine-phosphate diphosphorylase activity
A3L08_RS06895	COG1635	Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur
A3L08_RS06900	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
A3L08_RS06905	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
A3L08_RS06920	COG4145	pantothenate transmembrane transporter activity
A3L08_RS06935	COG2723	6-phospho-beta-galactosidase activity
A3L08_RS06940	COG4608	Belongs to the ABC transporter superfamily
A3L08_RS06945	COG0444	Belongs to the ABC transporter superfamily
A3L08_RS06950	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A3L08_RS06955	COG0601	transmembrane transport
A3L08_RS06980	COG2723	6-phospho-beta-galactosidase activity
A3L08_RS07005	COG4221	oxidoreductase activity
A3L08_RS07010	COG1505	serine-type exopeptidase activity
A3L08_RS07015	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
A3L08_RS07020	COG1201	RNA secondary structure unwinding
A3L08_RS07090	COG1363	Peptidase, m42
A3L08_RS07115	COG2814	Major facilitator Superfamily
A3L08_RS07120	COG2096	Adenosyltransferase
A3L08_RS07130	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
A3L08_RS07135	COG1546	Belongs to the CinA family
A3L08_RS07135	COG1058	Belongs to the CinA family
A3L08_RS07150	COG1872	DUF167
A3L08_RS07165	COG2361	Protein of unknown function DUF86
A3L08_RS07170	COG0423	glycine-tRNA ligase activity
A3L08_RS07190	COG0534	Mate efflux family protein
A3L08_RS07200	COG1867	N(2),N(2)-dimethylguanosine tRNA methyltransferase
A3L08_RS07215	COG0006	proline dipeptidase activity
A3L08_RS07230	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
A3L08_RS07235	COG4818	TM2 domain
A3L08_RS07255	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
A3L08_RS07270	COG0563	adenylate kinase activity
A3L08_RS07285	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
A3L08_RS07305	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
A3L08_RS07315	COG1121	(ABC) transporter
A3L08_RS07335	COG2205	protein histidine kinase activity
A3L08_RS07355	COG1401	restriction endodeoxyribonuclease activity
A3L08_RS07365	COG1469	GTP cyclohydrolase I activity
A3L08_RS07370	COG1078	dGTPase activity
A3L08_RS07375	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
A3L08_RS07380	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
A3L08_RS07385	COG0051	transcription antitermination factor activity, RNA binding
A3L08_RS07405	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
A3L08_RS07430	COG2403	cyclic 2,3-diphosphoglycerate synthetase activity
A3L08_RS07440	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
A3L08_RS07445	COG1125	glycine betaine transport
A3L08_RS07445	COG0517	IMP dehydrogenase activity
A3L08_RS07470	COG1121	(ABC) transporter
A3L08_RS07485	COG1205	dead DEAH box helicase
A3L08_RS07485	COG1111	helicase
A3L08_RS07490	COG1739	Uncharacterized protein family UPF0029
A3L08_RS07515	COG1216	Glycosyl transferase, family 2
A3L08_RS07540	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
A3L08_RS07540	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
A3L08_RS07555	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
A3L08_RS07565	COG1131	(ABC) transporter
A3L08_RS07570	COG0315	cyclic pyranopterin monophosphate synthase activity
A3L08_RS07580	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
A3L08_RS07585	COG0515	serine threonine protein kinase
A3L08_RS07590	COG0459	protein refolding
A3L08_RS07600	COG0501	Belongs to the peptidase M48B family
A3L08_RS07605	COG1028	Short-chain dehydrogenase reductase Sdr
A3L08_RS07610	COG1899	peptidyl-lysine modification to peptidyl-hypusine
A3L08_RS07620	COG3103	Sh3 type 3 domain protein
A3L08_RS07620	COG0366	Alpha amylase catalytic
A3L08_RS07640	COG1078	dGTPase activity
A3L08_RS07650	COG0303	'Molybdopterin
A3L08_RS07655	COG0521	Mo-molybdopterin cofactor biosynthetic process
A3L08_RS07660	COG0525	valine-tRNA ligase activity
A3L08_RS07710	COG2264	protein methyltransferase activity
A3L08_RS07715	COG1373	ATPase (AAA superfamily
A3L08_RS07725	COG0312	modulator of DNA gyrase
A3L08_RS07765	COG0598	Magnesium transport protein CorA
A3L08_RS07775	COG0012	GTP binding
A3L08_RS07790	COG0163	prenyltransferase activity
A3L08_RS07810	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
A3L08_RS07830	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
A3L08_RS07835	COG1993	acr, cog1993
A3L08_RS07860	COG1794	racemase activity, acting on amino acids and derivatives
A3L08_RS07880	COG0312	modulator of DNA gyrase
A3L08_RS07910	COG0546	phosphoglycolate phosphatase activity
A3L08_RS07920	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
A3L08_RS07930	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
A3L08_RS07970	COG0243	molybdopterin cofactor binding
A3L08_RS07975	COG0450	alkyl hydroperoxide reductase
A3L08_RS07985	COG0426	domain, Protein
A3L08_RS07990	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
A3L08_RS07995	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A3L08_RS08000	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
A3L08_RS08010	COG0864	Transcriptional regulator
A3L08_RS08025	COG2217	Heavy metal translocating P-type atpase
A3L08_RS08060	COG1401	restriction endodeoxyribonuclease activity
A3L08_RS08100	COG1028	Short-chain dehydrogenase reductase Sdr
A3L08_RS08115	COG2723	6-phospho-beta-galactosidase activity
A3L08_RS08125	COG0134	indole-3-glycerol-phosphate synthase activity
A3L08_RS08130	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
A3L08_RS08135	COG1528	Iron-storage protein
A3L08_RS08145	COG0778	Nitroreductase
A3L08_RS08150	COG1085	galactose-1-phosphate uridylyltransferase
A3L08_RS08155	COG2723	6-phospho-beta-galactosidase activity
A3L08_RS08170	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
A3L08_RS08200	COG2084	Dehydrogenase
A3L08_RS08210	COG1175	transmembrane transport
A3L08_RS08215	COG0395	ABC-type sugar transport system, permease component
A3L08_RS08220	COG0438	transferase activity, transferring glycosyl groups
A3L08_RS08225	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A3L08_RS08235	COG3842	ATPase activity
A3L08_RS08255	COG1592	Rubrerythrin
A3L08_RS08260	COG1773	rubredoxin
A3L08_RS08265	COG2033	superoxide reductase activity
A3L08_RS08325	COG1215	transferase activity, transferring glycosyl groups
A3L08_RS08335	COG0668	transmembrane transport
A3L08_RS08410	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
A3L08_RS08420	COG1301	dicarboxylic acid transport
A3L08_RS08425	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
A3L08_RS08425	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
A3L08_RS08435	COG1830	Aldolase
A3L08_RS08440	COG0511	ligase activity, forming carbon-carbon bonds
A3L08_RS08440	COG5016	pyruvate
A3L08_RS08445	COG1966	Carbon starvation protein
A3L08_RS08470	COG2267	carboxylic ester hydrolase activity
A3L08_RS08475	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
A3L08_RS08480	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A3L08_RS08490	COG0489	protein tyrosine kinase activity
A3L08_RS08495	COG0489	protein tyrosine kinase activity
A3L08_RS08515	COG2226	methyltransferase
A3L08_RS08520	COG0731	radical SAM domain protein
A3L08_RS08520	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
A3L08_RS08555	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
A3L08_RS08570	COG1342	Belongs to the UPF0251 family
A3L08_RS08575	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
A3L08_RS08600	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
A3L08_RS08650	COG0477	Major facilitator Superfamily
A3L08_RS08655	COG1201	RNA secondary structure unwinding
A3L08_RS08660	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A3L08_RS08675	COG1401	restriction endodeoxyribonuclease activity
A3L08_RS08685	COG0121	glutamine amidotransferase
A3L08_RS08695	COG1397	ADP-ribosylglycohydrolase
A3L08_RS08700	COG1397	ADP-ribosylglycohydrolase
A3L08_RS08730	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A3L08_RS08745	COG0084	hydrolase, TatD family'
A3L08_RS08770	COG0419	ATPase involved in DNA repair
A3L08_RS08770	COG0419	ATPase involved in DNA repair
A3L08_RS08785	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
A3L08_RS08790	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A3L08_RS08800	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
A3L08_RS08815	COG0105	UTP biosynthetic process
A3L08_RS08845	COG0175	sulfate reduction
A3L08_RS08860	COG0402	S-adenosylhomocysteine deaminase activity
A3L08_RS08865	COG0017	Asparaginyl-tRNA synthetase
A3L08_RS08875	COG4143	(ABC) transporter
A3L08_RS08895	COG1444	tRNA N-acetyltransferase activity
A3L08_RS08905	COG1506	peptidase
A3L08_RS08905	COG0823	Involved in the tonB-independent uptake of proteins
A3L08_RS08905	COG4946	Tricorn protease homolog
A3L08_RS08910	COG0488	(ABC) transporter
A3L08_RS08935	COG1268	BioY protein
A3L08_RS08940	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
A3L08_RS08940	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
A3L08_RS08945	COG1122	ATPase activity
A3L08_RS08950	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
A3L08_RS08975	COG1522	sequence-specific DNA binding
A3L08_RS08995	COG1178	ABC-type Fe3 transport system permease component
A3L08_RS09000	COG3842	ATPase activity
A3L08_RS09025	COG0126	phosphoglycerate kinase activity
A3L08_RS09050	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
A3L08_RS09050	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
A3L08_RS09060	COG0346	lactoylglutathione lyase activity
A3L08_RS09070	COG1196	nuclear chromosome segregation
A3L08_RS09085	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
A3L08_RS09105	COG0483	inositol monophosphate 1-phosphatase activity
A3L08_RS09115	COG1454	alcohol dehydrogenase
A3L08_RS09125	COG1984	allophanate hydrolase subunit 2
A3L08_RS09130	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
A3L08_RS09135	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
A3L08_RS09165	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
A3L08_RS09180	COG0330	HflC and HflK could
A3L08_RS09185	COG2894	cell division
A3L08_RS09200	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
A3L08_RS09215	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
A3L08_RS09245	COG1199	ATP-dependent helicase activity
A3L08_RS09265	COG1489	DNA binding
A3L08_RS09275	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
A3L08_RS09285	COG3473	Maleate cis-trans isomerase
A3L08_RS09290	COG0778	Nitroreductase
A3L08_RS09300	COG0301	tRNA thio-modification
A3L08_RS09310	COG0301	tRNA thio-modification
A3L08_RS09325	COG0045	succinate-CoA ligase (ADP-forming) activity
A3L08_RS09325	COG1042	CoA-binding domain protein
A3L08_RS09325	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A3L08_RS09350	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
A3L08_RS09360	COG0424	maF-like protein
A3L08_RS09375	COG4956	integral membrane protein (PIN domain superfamily)
A3L08_RS09380	COG2894	cell division
A3L08_RS09390	COG0367	asparagine synthase
A3L08_RS09405	COG0009	L-threonylcarbamoyladenylate synthase
A3L08_RS09425	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
A3L08_RS09430	COG0303	'Molybdopterin
A3L08_RS09440	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
A3L08_RS09455	COG1042	CoA-binding domain protein
A3L08_RS09455	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A3L08_RS09455	COG0045	succinate-CoA ligase (ADP-forming) activity
A3L08_RS09525	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
A3L08_RS09525	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
A3L08_RS09550	COG0071	Belongs to the small heat shock protein (HSP20) family
A3L08_RS09600	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
A3L08_RS09610	COG0778	Nitroreductase
A3L08_RS09620	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A3L08_RS09620	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A3L08_RS09630	COG0357	Ribosomal RNA small subunit methyltransferase G
A3L08_RS09660	COG1132	(ABC) transporter
A3L08_RS09665	COG1132	(ABC) transporter
A3L08_RS09705	COG1056	cytidyltransferase-related domain
A3L08_RS09705	COG1051	belongs to the nudix hydrolase family
A3L08_RS09725	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
A3L08_RS09755	COG0560	Phosphoserine phosphatase
A3L08_RS09760	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
A3L08_RS09780	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
A3L08_RS09785	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
A3L08_RS09800	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
A3L08_RS09815	COG0725	ABC transporter, periplasmic molybdate-binding protein
A3L08_RS09830	COG1160	GTP binding
A3L08_RS09835	COG0432	Pfam Uncharacterised protein family UPF0047