locus-tag	class	description
A0127_RS00010	COG1129	ABC transporter
A0127_RS00030	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
A0127_RS00045	COG0513	Belongs to the DEAD box helicase family
A0127_RS00065	COG1196	nuclear chromosome segregation
A0127_RS00075	COG1201	RNA secondary structure unwinding
A0127_RS00080	COG2814	Major facilitator Superfamily
A0127_RS00105	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A0127_RS00125	COG2267	carboxylic ester hydrolase activity
A0127_RS00145	COG2151	metal-sulfur cluster biosynthetic enzyme
A0127_RS00150	COG0003	Pfam Anion-transporting ATPase
A0127_RS00165	COG1966	Carbon starvation protein
A0127_RS00175	COG1830	Aldolase
A0127_RS00180	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
A0127_RS00180	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
A0127_RS00185	COG1301	dicarboxylic acid transport
A0127_RS00195	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
A0127_RS00215	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
A0127_RS00220	COG1518	maintenance of DNA repeat elements
A0127_RS00245	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
A0127_RS00250	COG0730	response to heat
A0127_RS00255	COG0423	glycine-tRNA ligase activity
A0127_RS00275	COG0534	Mate efflux family protein
A0127_RS00295	COG1867	N(2),N(2)-dimethylguanosine tRNA methyltransferase
A0127_RS00310	COG0006	proline dipeptidase activity
A0127_RS00350	COG1918	ferrous iron import across plasma membrane
A0127_RS00350	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
A0127_RS00360	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
A0127_RS00365	COG0424	maF-like protein
A0127_RS00375	COG4956	integral membrane protein (PIN domain superfamily)
A0127_RS00380	COG2894	cell division
A0127_RS00390	COG0367	asparagine synthase
A0127_RS00400	COG0009	L-threonylcarbamoyladenylate synthase
A0127_RS00445	COG0045	succinate-CoA ligase (ADP-forming) activity
A0127_RS00445	COG1042	CoA-binding domain protein
A0127_RS00445	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A0127_RS00470	COG2358	TRAP transporter, solute receptor (TAXI family
A0127_RS00495	COG0556	nucleotide-excision repair
A0127_RS00500	COG0101	tRNA pseudouridine synthase activity
A0127_RS00525	COG1063	alcohol dehydrogenase
A0127_RS00530	COG2894	cell division
A0127_RS00550	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
A0127_RS00555	COG0252	asparaginase activity
A0127_RS00565	COG1515	deoxyribonuclease V activity
A0127_RS00595	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
A0127_RS00605	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
A0127_RS00635	COG0438	transferase activity, transferring glycosyl groups
A0127_RS00640	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
A0127_RS00660	COG0475	glutathione-regulated potassium exporter activity
A0127_RS00665	COG0617	tRNA 3'-terminal CCA addition
A0127_RS00665	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
A0127_RS00665	COG3620	sequence-specific DNA binding
A0127_RS00670	COG0010	Belongs to the arginase family
A0127_RS00730	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
A0127_RS00745	COG0840	transmembrane signaling receptor activity
A0127_RS00750	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
A0127_RS00755	COG2201	protein-glutamate methylesterase activity
A0127_RS00760	COG2201	protein-glutamate methylesterase activity
A0127_RS00765	COG0643	Histidine kinase
A0127_RS00765	COG2198	Histidine kinase
A0127_RS00785	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
A0127_RS00800	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
A0127_RS00820	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
A0127_RS00825	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
A0127_RS00830	COG0667	Aldo Keto reductase
A0127_RS00840	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
A0127_RS00845	COG1522	sequence-specific DNA binding
A0127_RS00870	COG4221	oxidoreductase activity
A0127_RS00875	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
A0127_RS00915	COG0396	ATPase activity
A0127_RS00920	COG0301	tRNA thio-modification
A0127_RS00925	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
A0127_RS00930	COG0778	Nitroreductase
A0127_RS00960	COG1151	hydroxylamine reductase activity
A0127_RS00970	COG0446	pyridine nucleotide-disulphide oxidoreductase
A0127_RS01000	COG1013	pyruvate-flavodoxin oxidoreductase activity
A0127_RS01005	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
A0127_RS01045	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
A0127_RS01065	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
A0127_RS01075	COG1121	(ABC) transporter
A0127_RS01095	COG2205	protein histidine kinase activity
A0127_RS01115	COG1401	restriction endodeoxyribonuclease activity
A0127_RS01125	COG1469	GTP cyclohydrolase I activity
A0127_RS01135	COG1979	alcohol dehydrogenase
A0127_RS01145	COG0483	inositol monophosphate 1-phosphatase activity
A0127_RS01150	COG0457	Tetratricopeptide repeat
A0127_RS01150	COG0705	Rhomboid family
A0127_RS01165	COG1199	ATP-dependent helicase activity
A0127_RS01195	COG1489	DNA binding
A0127_RS01205	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
A0127_RS01215	COG1363	Peptidase, m42
A0127_RS01225	COG2409	Drug exporters of the RND superfamily
A0127_RS01240	COG1872	DUF167
A0127_RS01250	COG1201	RNA secondary structure unwinding
A0127_RS01260	COG1215	transferase activity, transferring glycosyl groups
A0127_RS01270	COG0343	queuine tRNA-ribosyltransferase activity
A0127_RS01285	COG0017	Asparaginyl-tRNA synthetase
A0127_RS01290	COG0402	S-adenosylhomocysteine deaminase activity
A0127_RS01295	COG4143	(ABC) transporter
A0127_RS01310	COG1444	tRNA N-acetyltransferase activity
A0127_RS01315	COG4946	Tricorn protease homolog
A0127_RS01315	COG0823	Involved in the tonB-independent uptake of proteins
A0127_RS01315	COG1506	peptidase
A0127_RS01340	COG1268	BioY protein
A0127_RS01345	COG1122	ATPase activity
A0127_RS01350	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
A0127_RS01385	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A0127_RS01395	COG0396	ATPase activity
A0127_RS01405	COG2226	methyltransferase
A0127_RS01460	COG2226	methyltransferase
A0127_RS01465	COG0731	radical SAM domain protein
A0127_RS01465	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
A0127_RS01470	COG0489	protein tyrosine kinase activity
A0127_RS01475	COG0489	protein tyrosine kinase activity
A0127_RS01485	COG0312	modulator of DNA gyrase
A0127_RS01490	COG0312	modulator of DNA gyrase
A0127_RS01500	COG0477	Major facilitator Superfamily
A0127_RS01505	COG0243	molybdopterin cofactor binding
A0127_RS01530	COG1011	Hydrolase
A0127_RS01535	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
A0127_RS01545	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
A0127_RS01550	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
A0127_RS01555	COG0515	serine threonine protein kinase
A0127_RS01565	COG0501	Belongs to the peptidase M48B family
A0127_RS01570	COG1028	Short-chain dehydrogenase reductase Sdr
A0127_RS01575	COG0493	'glutamate synthase
A0127_RS01585	COG1899	peptidyl-lysine modification to peptidyl-hypusine
A0127_RS01595	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
A0127_RS01610	COG0045	succinate-CoA ligase (ADP-forming) activity
A0127_RS01610	COG1042	CoA-binding domain protein
A0127_RS01610	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A0127_RS01635	COG1079	Belongs to the binding-protein-dependent transport system permease family
A0127_RS01640	COG4603	Belongs to the binding-protein-dependent transport system permease family
A0127_RS01645	COG3845	ABC transporter
A0127_RS01650	COG1744	ABC transporter substrate-binding protein PnrA-like
A0127_RS01660	COG0552	protein localization to endoplasmic reticulum
A0127_RS01700	COG2033	superoxide reductase activity
A0127_RS01705	COG1773	rubredoxin
A0127_RS01710	COG1592	Rubrerythrin
A0127_RS01715	COG1205	dead DEAH box helicase
A0127_RS01715	COG1111	helicase
A0127_RS01720	COG1739	Uncharacterized protein family UPF0029
A0127_RS01740	COG1993	acr, cog1993
A0127_RS01745	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
A0127_RS01785	COG0163	prenyltransferase activity
A0127_RS01790	COG1522	sequence-specific DNA binding
A0127_RS01800	COG0012	GTP binding
A0127_RS01805	COG0598	Magnesium transport protein CorA
A0127_RS01820	COG0312	modulator of DNA gyrase
A0127_RS01830	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
A0127_RS01850	COG3842	ATPase activity
A0127_RS01855	COG4208	sulfate ABC transporter
A0127_RS01875	COG1522	sequence-specific DNA binding
A0127_RS01900	COG1342	Belongs to the UPF0251 family
A0127_RS01905	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
A0127_RS01920	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
A0127_RS01930	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
A0127_RS01950	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
A0127_RS01955	COG0442	prolyl-tRNA aminoacylation
A0127_RS01960	COG2192	nodulation
A0127_RS01965	COG0436	Aminotransferase
A0127_RS01980	COG1812	S-adenosylmethionine synthetase (AdoMet synthetase)
A0127_RS01985	COG2342	PFAM TM1410 hypothetical-related protein
A0127_RS02005	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
A0127_RS02030	COG1078	dGTPase activity
A0127_RS02045	COG0450	alkyl hydroperoxide reductase
A0127_RS02075	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A0127_RS02075	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A0127_RS02090	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
A0127_RS02120	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A0127_RS02145	COG1320	monovalent cation:proton antiporter activity
A0127_RS02150	COG2212	antiporter activity
A0127_RS02155	COG1863	multisubunit Na H antiporter MnhE subunit
A0127_RS02190	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
A0127_RS02195	COG0534	Mate efflux family protein
A0127_RS02220	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
A0127_RS02220	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
A0127_RS02235	COG4145	pantothenate transmembrane transporter activity
A0127_RS02250	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
A0127_RS02260	COG1635	Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur
A0127_RS02265	COG0351	phosphomethylpyrimidine kinase
A0127_RS02275	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
A0127_RS02295	COG0215	cysteine-tRNA ligase activity
A0127_RS02325	COG1110	DNA topoisomerase II activity
A0127_RS02345	COG0010	Belongs to the arginase family
A0127_RS02350	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
A0127_RS02360	COG0546	phosphoglycolate phosphatase activity
A0127_RS02375	COG1418	mRNA catabolic process
A0127_RS02385	COG0017	Asparaginyl-tRNA synthetase
A0127_RS02395	COG1473	amidohydrolase
A0127_RS02450	COG0778	Nitroreductase
A0127_RS02460	COG0301	tRNA thio-modification
A0127_RS02470	COG0301	tRNA thio-modification
A0127_RS02485	COG1216	Glycosyl transferase, family 2
A0127_RS02525	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
A0127_RS02535	COG1131	(ABC) transporter
A0127_RS02540	COG0315	cyclic pyranopterin monophosphate synthase activity
A0127_RS02550	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
A0127_RS02565	COG2894	cell division
A0127_RS02570	COG0330	HflC and HflK could
A0127_RS02585	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
A0127_RS02605	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
A0127_RS02610	COG0860	N-Acetylmuramoyl-L-alanine amidase
A0127_RS02610	COG2247	cell wall binding repeat
A0127_RS02615	COG4956	integral membrane protein (PIN domain superfamily)
A0127_RS02620	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
A0127_RS02625	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
A0127_RS02630	COG1984	allophanate hydrolase subunit 2
A0127_RS02650	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
A0127_RS02650	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
A0127_RS02670	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A0127_RS02680	COG0084	hydrolase, TatD family'
A0127_RS02695	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A0127_RS02700	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A0127_RS02705	COG1078	dGTPase activity
A0127_RS02710	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
A0127_RS02720	COG0051	transcription antitermination factor activity, RNA binding
A0127_RS02730	COG0513	Belongs to the DEAD box helicase family
A0127_RS02750	COG0528	UMP kinase activity
A0127_RS02765	COG0535	radical SAM domain protein
A0127_RS02795	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
A0127_RS02805	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
A0127_RS02825	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
A0127_RS02830	COG0778	Nitroreductase
A0127_RS02925	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
A0127_RS02930	COG0157	Belongs to the NadC ModD family
A0127_RS02940	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
A0127_RS02945	COG3383	formate dehydrogenase (NAD+) activity
A0127_RS02950	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
A0127_RS02955	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
A0127_RS02965	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
A0127_RS02985	COG0151	Belongs to the GarS family
A0127_RS03000	COG0047	phosphoribosylformylglycinamidine synthase activity
A0127_RS03010	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
A0127_RS03025	COG0516	GMP reductase activity
A0127_RS03025	COG0517	IMP dehydrogenase activity
A0127_RS03030	COG0519	Catalyzes the synthesis of GMP from XMP
A0127_RS03030	COG0518	GMP synthase (glutamine-hydrolyzing) activity
A0127_RS03035	COG0519	Catalyzes the synthesis of GMP from XMP
A0127_RS03035	COG0518	GMP synthase (glutamine-hydrolyzing) activity
A0127_RS03040	COG1765	OsmC-like protein
A0127_RS03050	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
A0127_RS03055	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A0127_RS03060	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
A0127_RS03085	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
A0127_RS03090	COG0183	Belongs to the thiolase family
A0127_RS03115	COG2078	PFAM AMMECR1 domain protein
A0127_RS03120	COG0011	TIGRFAM Protein of
A0127_RS03160	COG4149	molybdate abc transporter
A0127_RS03165	COG3842	ATPase activity
A0127_RS03170	COG2252	PERMEase
A0127_RS03180	COG1185	polyribonucleotide nucleotidyltransferase activity
A0127_RS03205	COG0693	protein deglycase activity
A0127_RS03210	COG1522	sequence-specific DNA binding
A0127_RS03215	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
A0127_RS03230	COG1321	iron dependent repressor
A0127_RS03270	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A0127_RS03315	COG0456	acetyltransferase
A0127_RS03350	COG0123	including yeast histone deacetylase and acetoin utilization protein
A0127_RS03375	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
A0127_RS03405	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
A0127_RS03420	COG0509	glycine decarboxylation via glycine cleavage system
A0127_RS03435	COG0493	'glutamate synthase
A0127_RS03440	COG0543	2 iron, 2 sulfur cluster binding
A0127_RS03470	COG0747	negative chemotaxis
A0127_RS03475	COG0601	transmembrane transport
A0127_RS03480	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A0127_RS03485	COG0444	Belongs to the ABC transporter superfamily
A0127_RS03490	COG4608	Belongs to the ABC transporter superfamily
A0127_RS03520	COG1131	(ABC) transporter
A0127_RS03530	COG1476	TRANSCRIPTIONal
A0127_RS03550	COG2414	aldehyde ferredoxin oxidoreductase
A0127_RS03555	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
A0127_RS03575	COG1056	cytidyltransferase-related domain
A0127_RS03575	COG1051	belongs to the nudix hydrolase family
A0127_RS03595	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
A0127_RS03625	COG0560	Phosphoserine phosphatase
A0127_RS03630	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
A0127_RS03745	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
A0127_RS03755	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
A0127_RS03765	COG0546	phosphoglycolate phosphatase activity
A0127_RS03770	COG3842	ATPase activity
A0127_RS03775	COG4149	molybdate abc transporter
A0127_RS03780	COG0725	ABC transporter, periplasmic molybdate-binding protein
A0127_RS03795	COG1160	GTP binding
A0127_RS03820	COG1832	CoA-binding protein
A0127_RS03835	COG1451	nucleotide metabolic process
A0127_RS03840	COG0417	DNA replication proofreading
A0127_RS03845	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
A0127_RS03845	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
A0127_RS03855	COG1131	(ABC) transporter
A0127_RS03865	COG0585	pseudouridine synthase activity
A0127_RS03905	COG1851	Uncharacterised protein family (UPF0128)
A0127_RS03925	COG1850	ribulose-bisphosphate carboxylase activity
A0127_RS03970	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
A0127_RS03970	COG1213	nucleotidyl transferase
A0127_RS03985	COG0284	orotidine-5'-phosphate decarboxylase activity
A0127_RS03995	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
A0127_RS03995	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
A0127_RS04005	COG1192	Involved in chromosome partitioning
A0127_RS04010	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
A0127_RS04025	COG0436	Aminotransferase
A0127_RS04060	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
A0127_RS04065	COG0167	dihydroorotate dehydrogenase activity
A0127_RS04080	COG0501	Belongs to the peptidase M48B family
A0127_RS04085	COG2131	deaminase
A0127_RS04095	COG0546	phosphoglycolate phosphatase activity
A0127_RS04100	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
A0127_RS04110	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
A0127_RS04115	COG2271	Major facilitator Superfamily
A0127_RS04130	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
A0127_RS04140	COG1446	asparaginase
A0127_RS04165	COG2226	methyltransferase
A0127_RS04170	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
A0127_RS04225	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
A0127_RS04230	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
A0127_RS04235	COG1530	ribonuclease E activity
A0127_RS04245	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
A0127_RS04260	COG2255	four-way junction helicase activity
A0127_RS04265	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
A0127_RS04275	COG0156	8-amino-7-oxononanoate synthase activity
A0127_RS04290	COG0456	acetyltransferase
A0127_RS04295	COG0433	COG0433 Predicted ATPase
A0127_RS04305	COG0419	ATPase involved in DNA repair
A0127_RS04305	COG0419	ATPase involved in DNA repair
A0127_RS04315	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A0127_RS04325	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
A0127_RS04335	COG3885	ferrous iron binding
A0127_RS04335	COG2078	PFAM AMMECR1 domain protein
A0127_RS04360	COG0540	Belongs to the ATCase OTCase family
A0127_RS04365	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
A0127_RS04385	COG0237	dephospho-CoA kinase activity
A0127_RS04405	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
A0127_RS04435	COG0434	BtpA family
A0127_RS04455	COG0312	modulator of DNA gyrase
A0127_RS04460	COG0312	modulator of DNA gyrase
A0127_RS04475	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A0127_RS04490	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
A0127_RS04500	COG2234	aminopeptidase activity
A0127_RS04595	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
A0127_RS04600	COG2264	protein methyltransferase activity
A0127_RS04615	COG0668	transmembrane transport
A0127_RS04665	COG0218	Necessary for normal cell division and for the maintenance of normal septation
A0127_RS04670	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
A0127_RS04680	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
A0127_RS04730	COG1980	fructose-bisphosphate aldolase activity
A0127_RS04740	COG1233	COG1233 Phytoene dehydrogenase and related
A0127_RS04780	COG1346	cytolysis
A0127_RS04785	COG1380	Effector of murein hydrolase LrgA
A0127_RS04805	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
A0127_RS04815	COG1573	uracil-dna glycosylase
A0127_RS04820	COG1757	Na H antiporter
A0127_RS04840	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
A0127_RS04845	COG2894	cell division
A0127_RS04860	COG1522	sequence-specific DNA binding
A0127_RS04875	COG0235	Class ii aldolase
A0127_RS04885	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
A0127_RS04900	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
A0127_RS04910	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
A0127_RS04920	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
A0127_RS04965	COG0475	glutathione-regulated potassium exporter activity
A0127_RS04985	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
A0127_RS04990	COG0306	phosphate transporter
A0127_RS05005	COG0674	pyruvate-flavodoxin oxidoreductase activity
A0127_RS05010	COG1013	pyruvate-flavodoxin oxidoreductase activity
A0127_RS05015	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
A0127_RS05015	COG1144	Oxidoreductase
A0127_RS05020	COG0674	pyruvate-flavodoxin oxidoreductase activity
A0127_RS05025	COG1013	pyruvate-flavodoxin oxidoreductase activity
A0127_RS05040	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A0127_RS05045	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
A0127_RS05050	COG0489	protein tyrosine kinase activity
A0127_RS05075	COG1131	(ABC) transporter
A0127_RS05090	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A0127_RS05100	COG1254	Belongs to the acylphosphatase family
A0127_RS05110	COG1628	Protein of unknown function DUF99
A0127_RS05115	COG0589	response to stress
A0127_RS05120	COG0404	The glycine cleavage system catalyzes the degradation of glycine
A0127_RS05130	COG0681	Belongs to the peptidase S26 family
A0127_RS05155	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
A0127_RS05190	COG4946	Tricorn protease homolog
A0127_RS05190	COG0823	Involved in the tonB-independent uptake of proteins
A0127_RS05190	COG1506	peptidase
A0127_RS05210	COG1131	(ABC) transporter
A0127_RS05235	COG0306	phosphate transporter
A0127_RS05250	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
A0127_RS05295	COG1863	multisubunit Na H antiporter MnhE subunit
A0127_RS05300	COG2212	antiporter activity
A0127_RS05305	COG1320	monovalent cation:proton antiporter activity
A0127_RS05330	COG0651	ATP synthesis coupled electron transport
A0127_RS05340	COG3260	NADH ubiquinone oxidoreductase 20
A0127_RS05345	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
A0127_RS05345	COG3261	NADH dehydrogenase
A0127_RS05355	COG0650	Formate hydrogenlyase subunit 4
A0127_RS05390	COG0492	ferredoxin-NADP+ reductase activity
A0127_RS05395	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
A0127_RS05410	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
A0127_RS05420	COG0148	phosphopyruvate hydratase activity
A0127_RS05445	COG1522	sequence-specific DNA binding
A0127_RS05470	COG0314	molybdopterin synthase activity
A0127_RS05555	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
A0127_RS05565	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
A0127_RS05570	COG0045	succinate-CoA ligase (ADP-forming) activity
A0127_RS05570	COG1042	CoA-binding domain protein
A0127_RS05570	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A0127_RS05595	COG0095	Lipoate-protein ligase
A0127_RS05630	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
A0127_RS05750	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
A0127_RS05760	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
A0127_RS05775	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
A0127_RS05785	COG0402	S-adenosylhomocysteine deaminase activity
A0127_RS05790	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
A0127_RS05790	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
A0127_RS05805	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
A0127_RS05805	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
A0127_RS05830	COG0640	Transcriptional regulator
A0127_RS05840	COG1234	tRNA 3'-trailer cleavage
A0127_RS05850	COG2361	Protein of unknown function DUF86
A0127_RS05880	COG0180	Tryptophanyl-tRNA synthetase
A0127_RS05895	COG0179	Fumarylacetoacetate (FAA) hydrolase
A0127_RS05905	COG0116	Belongs to the methyltransferase superfamily
A0127_RS05905	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
A0127_RS05910	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
A0127_RS05945	COG1047	Peptidyl-prolyl cis-trans
A0127_RS05970	COG0714	Associated with various cellular activities
A0127_RS05990	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
A0127_RS06020	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A0127_RS06055	COG0037	tRNA processing
A0127_RS06065	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A0127_RS06080	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
A0127_RS06090	COG0475	glutathione-regulated potassium exporter activity
A0127_RS06090	COG0569	domain protein
A0127_RS06115	COG1449	Belongs to the glycosyl hydrolase 57 family
A0127_RS06140	COG0543	2 iron, 2 sulfur cluster binding
A0127_RS06145	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
A0127_RS06155	COG0601	transmembrane transport
A0127_RS06160	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A0127_RS06165	COG0444	Belongs to the ABC transporter superfamily
A0127_RS06170	COG4608	Belongs to the ABC transporter superfamily
A0127_RS06190	COG0174	glutamine synthetase
A0127_RS06230	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
A0127_RS06250	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
A0127_RS06290	COG0732	type I restriction modification DNA specificity domain
A0127_RS06300	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
A0127_RS06325	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A0127_RS06330	COG1234	tRNA 3'-trailer cleavage
A0127_RS06335	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
A0127_RS06345	COG3842	ATPase activity
A0127_RS06355	COG3833	ABC-type maltose transport systems, permease component
A0127_RS06370	COG1378	Sugar-specific transcriptional regulator TrmB
A0127_RS06375	COG0297	glycogen (starch) synthase activity
A0127_RS06435	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
A0127_RS06450	COG1131	(ABC) transporter
A0127_RS06460	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A0127_RS06460	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A0127_RS06490	COG0714	Associated with various cellular activities
A0127_RS06515	COG1216	Glycosyl transferase, family 2
A0127_RS06525	COG0438	transferase activity, transferring glycosyl groups
A0127_RS06530	COG3119	arylsulfatase activity
A0127_RS06535	COG1216	Glycosyl transferase, family 2
A0127_RS06550	COG0562	UDP-galactopyranose mutase
A0127_RS06555	COG3119	arylsulfatase activity
A0127_RS06620	COG1216	Glycosyl transferase, family 2
A0127_RS06620	COG0463	Glycosyl transferase, family 2
A0127_RS06625	COG3119	arylsulfatase activity
A0127_RS06630	COG0463	Glycosyl transferase, family 2
A0127_RS06640	COG0438	transferase activity, transferring glycosyl groups
A0127_RS06645	COG1216	Glycosyl transferase, family 2
A0127_RS06645	COG1442	glycosyl transferase family 8
A0127_RS06660	COG0730	response to heat
A0127_RS06665	COG0529	Catalyzes the synthesis of activated sulfate
A0127_RS06690	COG2046	Belongs to the sulfate adenylyltransferase family
A0127_RS06700	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
A0127_RS06785	COG1141	Ferredoxin
A0127_RS06790	COG2151	metal-sulfur cluster biosynthetic enzyme
A0127_RS06815	COG1404	Belongs to the peptidase S8 family
A0127_RS06835	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
A0127_RS06845	COG0543	2 iron, 2 sulfur cluster binding
A0127_RS06850	COG0493	'glutamate synthase
A0127_RS06880	COG2890	protein-(glutamine-N5) methyltransferase activity
A0127_RS06940	COG2095	MarC family integral membrane protein
A0127_RS06955	COG0252	asparaginase activity
A0127_RS06965	COG1695	Transcriptional regulator
A0127_RS06970	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
A0127_RS06970	COG2050	protein possibly involved in aromatic compounds catabolism
A0127_RS06980	COG1335	isochorismatase
A0127_RS07005	COG1013	pyruvate-flavodoxin oxidoreductase activity
A0127_RS07045	COG1185	polyribonucleotide nucleotidyltransferase activity
A0127_RS07050	COG1185	polyribonucleotide nucleotidyltransferase activity
A0127_RS07085	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
A0127_RS07085	COG0517	IMP dehydrogenase activity
A0127_RS07090	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
A0127_RS07095	COG0511	ligase activity, forming carbon-carbon bonds
A0127_RS07095	COG5016	pyruvate
A0127_RS07105	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
A0127_RS07140	COG0430	RNA-3'-phosphate cyclase activity
A0127_RS07145	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
A0127_RS07155	COG0543	2 iron, 2 sulfur cluster binding
A0127_RS07165	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
A0127_RS07200	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
A0127_RS07205	COG5278	phosphoserine phosphatase activity
A0127_RS07205	COG0840	transmembrane signaling receptor activity
A0127_RS07230	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
A0127_RS07235	COG1436	Produces ATP from ADP in the presence of a proton gradient across the membrane
A0127_RS07245	COG1390	Produces ATP from ADP in the presence of a proton gradient across the membrane
A0127_RS07255	COG1269	ATP hydrolysis coupled proton transport
A0127_RS07265	COG0569	domain protein
A0127_RS07270	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
A0127_RS07280	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
A0127_RS07290	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
A0127_RS07310	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
A0127_RS07325	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
A0127_RS07350	COG2095	MarC family integral membrane protein
A0127_RS07365	COG0840	transmembrane signaling receptor activity
A0127_RS07380	COG0475	glutathione-regulated potassium exporter activity
A0127_RS07385	COG0475	glutathione-regulated potassium exporter activity
A0127_RS07390	COG0516	GMP reductase activity
A0127_RS07390	COG0517	IMP dehydrogenase activity
A0127_RS07395	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
A0127_RS07400	COG0037	tRNA processing
A0127_RS07410	COG1215	transferase activity, transferring glycosyl groups
A0127_RS07425	COG0482	sulfurtransferase activity
A0127_RS07430	COG0017	Asparaginyl-tRNA synthetase
A0127_RS07440	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
A0127_RS07480	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
A0127_RS07490	COG0089	rRNA binding
A0127_RS07495	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
A0127_RS07500	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
A0127_RS07510	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
A0127_RS07515	COG0255	Belongs to the universal ribosomal protein uL29 family
A0127_RS07530	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
A0127_RS07535	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
A0127_RS07540	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
A0127_RS07550	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
A0127_RS07560	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
A0127_RS07565	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
A0127_RS07580	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
A0127_RS07585	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
A0127_RS07590	COG1841	ribosomal large subunit assembly
A0127_RS07595	COG0200	Binds to the 23S rRNA
A0127_RS07620	COG1102	Psort location Cytoplasmic, score
A0127_RS07630	COG1028	Short-chain dehydrogenase reductase Sdr
A0127_RS07635	COG1598	PFAM Uncharacterised protein family UPF0150
A0127_RS07640	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
A0127_RS07650	COG2813	Specifically methylates the guanine in position
A0127_RS07660	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
A0127_RS07665	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
A0127_RS07675	COG0202	RNA polymerase activity
A0127_RS07690	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
A0127_RS07695	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
A0127_RS07715	COG0148	phosphopyruvate hydratase activity
A0127_RS07720	COG0052	Belongs to the universal ribosomal protein uS2 family
A0127_RS07735	COG1695	Transcriptional regulator
A0127_RS07755	COG1522	sequence-specific DNA binding
A0127_RS07780	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
A0127_RS07795	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
A0127_RS07800	COG0446	pyridine nucleotide-disulphide oxidoreductase
A0127_RS07820	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
A0127_RS07825	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
A0127_RS07830	COG1355	regulation of microtubule-based process
A0127_RS07835	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
A0127_RS07850	COG1546	Belongs to the CinA family
A0127_RS07850	COG1058	Belongs to the CinA family
A0127_RS07855	COG1794	racemase activity, acting on amino acids and derivatives
A0127_RS07860	COG1304	FMN binding
A0127_RS07880	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A0127_RS07880	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A0127_RS07895	COG0495	leucyl-tRNA aminoacylation
A0127_RS07925	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
A0127_RS07940	COG0864	Transcriptional regulator
A0127_RS07955	COG1543	Belongs to the glycosyl hydrolase 57 family
A0127_RS07960	COG0347	Belongs to the P(II) protein family
A0127_RS07970	COG0733	neurotransmitter:sodium symporter activity
A0127_RS07975	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
A0127_RS07985	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
A0127_RS07990	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
A0127_RS08000	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
A0127_RS08025	COG1458	PINc domain ribonuclease
A0127_RS08045	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
A0127_RS08060	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
A0127_RS08065	COG0081	regulation of translation
A0127_RS08085	COG0717	Belongs to the dCTP deaminase family
A0127_RS08115	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
A0127_RS08125	COG0058	SHG alpha-glucan phosphorylase activity
A0127_RS08130	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
A0127_RS08140	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
A0127_RS08145	COG1073	alpha beta
A0127_RS08150	COG2271	Major facilitator Superfamily
A0127_RS08155	COG2211	Major facilitator Superfamily
A0127_RS08160	COG0584	glycerophosphoryl diester phosphodiesterase
A0127_RS08165	COG0584	glycerophosphoryl diester phosphodiesterase
A0127_RS08175	COG0579	oxidoreductase
A0127_RS08205	COG2339	peptidase activity
A0127_RS08235	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
A0127_RS08240	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
A0127_RS08265	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
A0127_RS08270	COG0840	transmembrane signaling receptor activity
A0127_RS08275	COG0534	Mate efflux family protein
A0127_RS08330	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
A0127_RS08330	COG0574	Belongs to the PEP-utilizing enzyme family
A0127_RS08345	COG1404	Belongs to the peptidase S8 family
A0127_RS08360	COG0446	pyridine nucleotide-disulphide oxidoreductase
A0127_RS08385	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
A0127_RS08405	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
A0127_RS08415	COG1528	Iron-storage protein
A0127_RS08420	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
A0127_RS08430	COG0105	UTP biosynthetic process
A0127_RS08460	COG0175	sulfate reduction
A0127_RS08465	COG0330	HflC and HflK could
A0127_RS08505	COG0303	'Molybdopterin
A0127_RS08545	COG0525	valine-tRNA ligase activity
A0127_RS08550	COG2226	methyltransferase
A0127_RS08555	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
A0127_RS08560	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
A0127_RS08585	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
A0127_RS08605	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A0127_RS08620	COG1476	TRANSCRIPTIONal
A0127_RS08625	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
A0127_RS08640	COG0640	Transcriptional regulator
A0127_RS08645	COG1694	Mazg nucleotide pyrophosphohydrolase
A0127_RS08650	COG1522	sequence-specific DNA binding
A0127_RS08655	COG1836	PFAM Integral membrane protein DUF92
A0127_RS08660	COG0301	tRNA thio-modification
A0127_RS08660	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A0127_RS08680	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
A0127_RS08740	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A0127_RS08745	COG0018	arginyl-trna synthetase
A0127_RS08775	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
A0127_RS08800	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
A0127_RS08810	COG1863	multisubunit Na H antiporter MnhE subunit
A0127_RS08820	COG1320	monovalent cation:proton antiporter activity
A0127_RS08830	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
A0127_RS08830	COG2111	Na H antiporter
A0127_RS08835	COG1006	Multisubunit Na H antiporter MnhC subunit
A0127_RS08840	COG0651	ATP synthesis coupled electron transport
A0127_RS08845	COG0651	ATP synthesis coupled electron transport
A0127_RS08855	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A0127_RS08860	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A0127_RS08865	COG0649	NAD binding
A0127_RS08915	COG1881	PFAM PEBP family protein
A0127_RS08920	COG1028	Short-chain dehydrogenase reductase Sdr
A0127_RS08950	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
A0127_RS08980	COG0504	CTP synthase activity
A0127_RS08995	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
A0127_RS09020	COG0517	IMP dehydrogenase activity
A0127_RS09020	COG0516	GMP reductase activity
A0127_RS09030	COG0024	Methionine aminopeptidase
A0127_RS09035	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
A0127_RS09040	COG1122	ATPase activity
A0127_RS09080	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
A0127_RS09095	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
A0127_RS09135	COG0628	permease
A0127_RS09140	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
A0127_RS09165	COG0071	Belongs to the small heat shock protein (HSP20) family
A0127_RS09195	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
A0127_RS09195	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
A0127_RS09210	COG0126	phosphoglycerate kinase activity
A0127_RS09230	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
A0127_RS09235	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
A0127_RS09255	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
A0127_RS09275	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
A0127_RS09275	COG0674	pyruvate-flavodoxin oxidoreductase activity
A0127_RS09280	COG1013	pyruvate-flavodoxin oxidoreductase activity
A0127_RS09290	COG0674	pyruvate-flavodoxin oxidoreductase activity
A0127_RS09290	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
A0127_RS09295	COG1013	pyruvate-flavodoxin oxidoreductase activity
A0127_RS09320	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
A0127_RS09330	COG0425	Belongs to the sulfur carrier protein TusA family
A0127_RS09335	COG0426	domain, Protein
A0127_RS09345	COG0006	proline dipeptidase activity
A0127_RS09350	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A0127_RS09365	COG2226	methyltransferase
A0127_RS09370	COG1122	ATPase activity
A0127_RS09380	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
A0127_RS09385	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
A0127_RS09385	COG2111	Na H antiporter
A0127_RS09395	COG1320	monovalent cation:proton antiporter activity
A0127_RS09410	COG1006	Multisubunit Na H antiporter MnhC subunit
A0127_RS09415	COG1863	multisubunit Na H antiporter MnhE subunit
A0127_RS09420	COG0651	ATP synthesis coupled electron transport
A0127_RS09440	COG0409	Hydrogenase expression formation protein
A0127_RS09445	COG0298	carbon dioxide binding
A0127_RS09460	COG1309	transcriptional regulator
A0127_RS09465	COG3383	formate dehydrogenase (NAD+) activity
A0127_RS09475	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
A0127_RS09475	COG2111	Na H antiporter
A0127_RS09480	COG0651	ATP synthesis coupled electron transport
A0127_RS09485	COG0650	Formate hydrogenlyase subunit 4
A0127_RS09490	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
A0127_RS09490	COG3261	NADH dehydrogenase
A0127_RS09495	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A0127_RS09500	COG3260	NADH ubiquinone oxidoreductase 20
A0127_RS09515	COG0746	molybdenum cofactor guanylyltransferase activity
A0127_RS09525	COG0489	protein tyrosine kinase activity
A0127_RS09530	COG0375	protein maturation
A0127_RS09535	COG1230	cation diffusion facilitator family transporter
A0127_RS09550	COG1137	ATPase activity
A0127_RS09560	COG0535	radical SAM domain protein
A0127_RS09630	COG2414	aldehyde ferredoxin oxidoreductase
A0127_RS09635	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
A0127_RS09665	COG2414	aldehyde ferredoxin oxidoreductase
A0127_RS09675	COG1234	tRNA 3'-trailer cleavage
A0127_RS09690	COG2140	Oxalate decarboxylase
A0127_RS09705	COG1122	ATPase activity
A0127_RS09715	COG0310	cobalt ion transport
A0127_RS09720	COG0310	cobalt ion transport
A0127_RS09735	COG1185	polyribonucleotide nucleotidyltransferase activity
A0127_RS09765	COG0436	Aminotransferase
A0127_RS09780	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
A0127_RS09795	COG0644	oxidoreductase
A0127_RS09820	COG0085	RNA polymerase activity
A0127_RS09825	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
A0127_RS09830	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
A0127_RS09850	COG0049	tRNA binding
A0127_RS09875	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
A0127_RS09885	COG2414	aldehyde ferredoxin oxidoreductase
A0127_RS09900	COG2076	Multidrug Resistance protein
A0127_RS09910	COG0668	transmembrane transport
A0127_RS09930	COG0735	belongs to the Fur family
A0127_RS09950	COG0730	response to heat
A0127_RS09985	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
A0127_RS09990	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
A0127_RS10000	COG2096	Adenosyltransferase
A0127_RS10005	COG2814	Major facilitator Superfamily
A0127_RS10020	COG0640	Transcriptional regulator
A0127_RS10030	COG2403	cyclic 2,3-diphosphoglycerate synthetase activity
A0127_RS10040	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
A0127_RS10045	COG0517	IMP dehydrogenase activity
A0127_RS10045	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
A0127_RS10075	COG0798	PFAM Bile acid sodium symporter
A0127_RS10095	COG3118	belongs to the thioredoxin family
A0127_RS10100	COG2217	Heavy metal translocating P-type atpase
A0127_RS10125	COG2226	methyltransferase
A0127_RS10145	COG0626	cystathionine gamma-synthase activity
A0127_RS10170	COG2217	Heavy metal translocating P-type atpase
A0127_RS10180	COG0631	protein serine/threonine phosphatase activity
A0127_RS10190	COG2815	serine threonine protein kinase
A0127_RS10190	COG0515	serine threonine protein kinase
A0127_RS10250	COG2217	Heavy metal translocating P-type atpase
A0127_RS10255	COG0640	Transcriptional regulator
A0127_RS10285	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A0127_RS10290	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A0127_RS10315	COG0450	alkyl hydroperoxide reductase
A0127_RS10385	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
A0127_RS10425	COG0305	Participates in initiation and elongation during chromosome replication
A0127_RS10425	COG1372	Participates in initiation and elongation during chromosome replication