locus-tag	class	description
TSIB_RS00025	COG1215	transferase activity, transferring glycosyl groups
TSIB_RS00030	COG0463	Glycosyl transferase, family 2
TSIB_RS00050	COG0714	Associated with various cellular activities
TSIB_RS00115	COG0647	UMP catabolic process
TSIB_RS00130	COG0557	exoribonuclease II activity
TSIB_RS00155	COG2264	protein methyltransferase activity
TSIB_RS00170	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
TSIB_RS00220	COG0518	GMP synthase (glutamine-hydrolyzing) activity
TSIB_RS00220	COG0519	Catalyzes the synthesis of GMP from XMP
TSIB_RS00235	COG0518	GMP synthase (glutamine-hydrolyzing) activity
TSIB_RS00235	COG0519	Catalyzes the synthesis of GMP from XMP
TSIB_RS00240	COG0516	GMP reductase activity
TSIB_RS00240	COG0517	IMP dehydrogenase activity
TSIB_RS00270	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
TSIB_RS00275	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
TSIB_RS00280	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
TSIB_RS00285	COG0047	phosphoribosylformylglycinamidine synthase activity
TSIB_RS00300	COG0151	Belongs to the GarS family
TSIB_RS00315	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
TSIB_RS00320	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
TSIB_RS00325	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
TSIB_RS00330	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
TSIB_RS00335	COG3383	formate dehydrogenase (NAD+) activity
TSIB_RS00365	COG0668	transmembrane transport
TSIB_RS00370	COG2264	protein methyltransferase activity
TSIB_RS00395	COG0124	histidyl-tRNA synthetase
TSIB_RS00425	COG1346	cytolysis
TSIB_RS00430	COG1380	Effector of murein hydrolase LrgA
TSIB_RS00435	COG0251	oxidation-reduction process
TSIB_RS00445	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
TSIB_RS00455	COG1215	transferase activity, transferring glycosyl groups
TSIB_RS00465	COG0343	queuine tRNA-ribosyltransferase activity
TSIB_RS00480	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
TSIB_RS00490	COG0456	acetyltransferase
TSIB_RS00500	COG0156	8-amino-7-oxononanoate synthase activity
TSIB_RS00505	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
TSIB_RS00510	COG2255	four-way junction helicase activity
TSIB_RS00525	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
TSIB_RS00535	COG1530	ribonuclease E activity
TSIB_RS00540	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
TSIB_RS00545	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
TSIB_RS00555	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
TSIB_RS00615	COG2252	PERMEase
TSIB_RS00620	COG0281	malic enzyme
TSIB_RS00635	COG2151	metal-sulfur cluster biosynthetic enzyme
TSIB_RS00640	COG1141	Ferredoxin
TSIB_RS00645	COG1141	Ferredoxin
TSIB_RS00665	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TSIB_RS00665	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TSIB_RS00680	COG0730	response to heat
TSIB_RS00685	COG1363	Peptidase, m42
TSIB_RS00730	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
TSIB_RS00740	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
TSIB_RS00745	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
TSIB_RS00770	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
TSIB_RS00785	COG2403	cyclic 2,3-diphosphoglycerate synthetase activity
TSIB_RS00790	COG0725	ABC transporter, periplasmic molybdate-binding protein
TSIB_RS00795	COG4149	molybdate abc transporter
TSIB_RS00800	COG3842	ATPase activity
TSIB_RS00810	COG1201	RNA secondary structure unwinding
TSIB_RS00820	COG1505	serine-type exopeptidase activity
TSIB_RS00840	COG1047	Peptidyl-prolyl cis-trans
TSIB_RS00845	COG0215	cysteine-tRNA ligase activity
TSIB_RS00850	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
TSIB_RS00850	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
TSIB_RS00855	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
TSIB_RS00870	COG1079	Belongs to the binding-protein-dependent transport system permease family
TSIB_RS00875	COG4603	Belongs to the binding-protein-dependent transport system permease family
TSIB_RS00880	COG3845	ABC transporter
TSIB_RS00885	COG1744	ABC transporter substrate-binding protein PnrA-like
TSIB_RS00895	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
TSIB_RS00905	COG2226	methyltransferase
TSIB_RS00940	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
TSIB_RS00960	COG1992	Thiamine-phosphate synthase
TSIB_RS00960	COG0351	phosphomethylpyrimidine kinase
TSIB_RS00970	COG0432	Pfam Uncharacterised protein family UPF0047
TSIB_RS00975	COG1234	tRNA 3'-trailer cleavage
TSIB_RS01000	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
TSIB_RS01000	COG1042	CoA-binding domain protein
TSIB_RS01000	COG0045	succinate-CoA ligase (ADP-forming) activity
TSIB_RS01020	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
TSIB_RS01045	COG0126	phosphoglycerate kinase activity
TSIB_RS01075	COG1178	ABC-type Fe3 transport system permease component
TSIB_RS01100	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
TSIB_RS01115	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
TSIB_RS01115	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
TSIB_RS01120	COG1830	Aldolase
TSIB_RS01130	COG1966	Carbon starvation protein
TSIB_RS01160	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
TSIB_RS01160	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
TSIB_RS01200	COG0010	Belongs to the arginase family
TSIB_RS01220	COG3769	mannosylglycerate metabolic process
TSIB_RS01235	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
TSIB_RS01235	COG1793	dna ligase
TSIB_RS01240	COG0509	glycine decarboxylation via glycine cleavage system
TSIB_RS01250	COG0495	leucyl-tRNA aminoacylation
TSIB_RS01275	COG0446	pyridine nucleotide-disulphide oxidoreductase
TSIB_RS01295	COG1404	Belongs to the peptidase S8 family
TSIB_RS01300	COG1473	amidohydrolase
TSIB_RS01315	COG0574	Belongs to the PEP-utilizing enzyme family
TSIB_RS01315	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
TSIB_RS01325	COG0534	Mate efflux family protein
TSIB_RS01340	COG1446	asparaginase
TSIB_RS01345	COG2814	Major facilitator Superfamily
TSIB_RS01350	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
TSIB_RS01365	COG2271	Major facilitator Superfamily
TSIB_RS01380	COG1941	NADH ubiquinone oxidoreductase 20 kDa subunit
TSIB_RS01400	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
TSIB_RS01415	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
TSIB_RS01420	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
TSIB_RS01425	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
TSIB_RS01435	COG0255	Belongs to the universal ribosomal protein uL29 family
TSIB_RS01450	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
TSIB_RS01455	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
TSIB_RS01460	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
TSIB_RS01470	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
TSIB_RS01480	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
TSIB_RS01485	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
TSIB_RS01500	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
TSIB_RS01505	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
TSIB_RS01515	COG0200	Binds to the 23S rRNA
TSIB_RS01540	COG1102	Psort location Cytoplasmic, score
TSIB_RS01550	COG1028	Short-chain dehydrogenase reductase Sdr
TSIB_RS01555	COG4221	oxidoreductase activity
TSIB_RS01610	COG0601	transmembrane transport
TSIB_RS01615	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TSIB_RS01620	COG0444	Belongs to the ABC transporter superfamily
TSIB_RS01630	COG2723	6-phospho-beta-galactosidase activity
TSIB_RS01640	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
TSIB_RS01650	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
TSIB_RS01655	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
TSIB_RS01660	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
TSIB_RS01680	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
TSIB_RS01685	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
TSIB_RS01705	COG0148	phosphopyruvate hydratase activity
TSIB_RS01710	COG0052	Belongs to the universal ribosomal protein uS2 family
TSIB_RS01720	COG0301	tRNA thio-modification
TSIB_RS01730	COG0301	tRNA thio-modification
TSIB_RS01735	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
TSIB_RS01745	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
TSIB_RS01750	COG1653	transport
TSIB_RS01755	COG1175	transmembrane transport
TSIB_RS01760	COG0395	ABC-type sugar transport system, permease component
TSIB_RS01765	COG0438	transferase activity, transferring glycosyl groups
TSIB_RS01775	COG3842	ATPase activity
TSIB_RS01795	COG4208	sulfate ABC transporter
TSIB_RS01800	COG3842	ATPase activity
TSIB_RS01805	COG4143	(ABC) transporter
TSIB_RS01815	COG0434	BtpA family
TSIB_RS01820	COG1458	PINc domain ribonuclease
TSIB_RS01845	COG2358	TRAP transporter, solute receptor (TAXI family
TSIB_RS01855	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
TSIB_RS01870	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
TSIB_RS01875	COG0081	regulation of translation
TSIB_RS01890	COG0717	Belongs to the dCTP deaminase family
TSIB_RS01925	COG0085	RNA polymerase activity
TSIB_RS01930	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
TSIB_RS01935	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
TSIB_RS01955	COG0049	tRNA binding
TSIB_RS01965	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
TSIB_RS01990	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
TSIB_RS01995	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
TSIB_RS02045	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
TSIB_RS02050	COG2095	MarC family integral membrane protein
TSIB_RS02065	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
TSIB_RS02085	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
TSIB_RS02135	COG0010	Belongs to the arginase family
TSIB_RS02140	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
TSIB_RS02165	COG1418	mRNA catabolic process
TSIB_RS02175	COG0017	Asparaginyl-tRNA synthetase
TSIB_RS02190	COG0585	pseudouridine synthase activity
TSIB_RS02200	COG0284	orotidine-5'-phosphate decarboxylase activity
TSIB_RS02205	COG0167	dihydroorotate dehydrogenase activity
TSIB_RS02215	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
TSIB_RS02220	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
TSIB_RS02225	COG0540	Belongs to the ATCase OTCase family
TSIB_RS02230	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
TSIB_RS02240	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
TSIB_RS02245	COG1522	sequence-specific DNA binding
TSIB_RS02255	COG0475	glutathione-regulated potassium exporter activity
TSIB_RS02260	COG0475	glutathione-regulated potassium exporter activity
TSIB_RS02275	COG0037	tRNA processing
TSIB_RS02280	COG1449	Belongs to the glycosyl hydrolase 57 family
TSIB_RS02300	COG0475	glutathione-regulated potassium exporter activity
TSIB_RS02315	COG0351	phosphomethylpyrimidine kinase
TSIB_RS02325	COG0352	thiamine-phosphate diphosphorylase activity
TSIB_RS02330	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
TSIB_RS02335	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
TSIB_RS02345	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
TSIB_RS02355	COG1058	Belongs to the CinA family
TSIB_RS02355	COG1546	Belongs to the CinA family
TSIB_RS02360	COG0469	pyruvate kinase activity
TSIB_RS02375	COG2414	aldehyde ferredoxin oxidoreductase
TSIB_RS02405	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
TSIB_RS02410	COG1993	acr, cog1993
TSIB_RS02425	COG0668	transmembrane transport
TSIB_RS02430	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
TSIB_RS02440	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
TSIB_RS02470	COG0616	signal peptide processing
TSIB_RS02480	COG0628	permease
TSIB_RS02505	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
TSIB_RS02515	COG0163	prenyltransferase activity
TSIB_RS02530	COG0012	GTP binding
TSIB_RS02555	COG0534	Mate efflux family protein
TSIB_RS02560	COG1867	N(2),N(2)-dimethylguanosine tRNA methyltransferase
TSIB_RS02585	COG0071	Belongs to the small heat shock protein (HSP20) family
TSIB_RS02595	COG0693	protein deglycase activity
TSIB_RS02600	COG1534	Rna-binding protein
TSIB_RS02630	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
TSIB_RS02630	COG1042	CoA-binding domain protein
TSIB_RS02630	COG0045	succinate-CoA ligase (ADP-forming) activity
TSIB_RS02635	COG1110	DNA topoisomerase II activity
TSIB_RS02655	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
TSIB_RS02660	COG0105	UTP biosynthetic process
TSIB_RS02675	COG0312	modulator of DNA gyrase
TSIB_RS02680	COG0312	modulator of DNA gyrase
TSIB_RS02725	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
TSIB_RS02730	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
TSIB_RS02760	COG0419	ATPase involved in DNA repair
TSIB_RS02815	COG0243	molybdopterin cofactor binding
TSIB_RS02830	COG0656	L-ascorbic acid biosynthetic process
TSIB_RS02855	COG1185	polyribonucleotide nucleotidyltransferase activity
TSIB_RS02875	COG1085	galactose-1-phosphate uridylyltransferase
TSIB_RS02895	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
TSIB_RS02900	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
TSIB_RS02965	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TSIB_RS02980	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
TSIB_RS03010	COG0252	asparaginase activity
TSIB_RS03015	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
TSIB_RS03035	COG2894	cell division
TSIB_RS03045	COG1063	alcohol dehydrogenase
TSIB_RS03060	COG0101	tRNA pseudouridine synthase activity
TSIB_RS03065	COG0556	nucleotide-excision repair
TSIB_RS03075	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
TSIB_RS03085	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
TSIB_RS03095	COG1011	Hydrolase
TSIB_RS03110	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
TSIB_RS03130	COG0733	neurotransmitter:sodium symporter activity
TSIB_RS03170	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
TSIB_RS03205	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
TSIB_RS03210	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
TSIB_RS03250	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
TSIB_RS03255	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
TSIB_RS03260	COG0404	The glycine cleavage system catalyzes the degradation of glycine
TSIB_RS03265	COG0589	response to stress
TSIB_RS03285	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
TSIB_RS03300	COG1121	(ABC) transporter
TSIB_RS03305	COG1205	dead DEAH box helicase
TSIB_RS03305	COG1111	helicase
TSIB_RS03320	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
TSIB_RS03335	COG0330	HflC and HflK could
TSIB_RS03340	COG2894	cell division
TSIB_RS03365	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
TSIB_RS03380	COG0513	Belongs to the DEAD box helicase family
TSIB_RS03385	COG1342	Belongs to the UPF0251 family
TSIB_RS03395	COG0489	protein tyrosine kinase activity
TSIB_RS03400	COG0489	protein tyrosine kinase activity
TSIB_RS03415	COG0598	Magnesium transport protein CorA
TSIB_RS03425	COG2226	methyltransferase
TSIB_RS03430	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
TSIB_RS03430	COG0731	radical SAM domain protein
TSIB_RS03455	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
TSIB_RS03495	COG0109	protoheme IX farnesyltransferase activity
TSIB_RS03505	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
TSIB_RS03510	COG0218	Necessary for normal cell division and for the maintenance of normal septation
TSIB_RS03530	COG0477	Major facilitator Superfamily
TSIB_RS03550	COG1196	nuclear chromosome segregation
TSIB_RS03565	COG0483	inositol monophosphate 1-phosphatase activity
TSIB_RS03575	COG1979	alcohol dehydrogenase
TSIB_RS03585	COG1984	allophanate hydrolase subunit 2
TSIB_RS03590	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
TSIB_RS03595	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
TSIB_RS03635	COG0864	Transcriptional regulator
TSIB_RS03670	COG1192	Involved in chromosome partitioning
TSIB_RS03685	COG0720	synthase
TSIB_RS03695	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
TSIB_RS03705	COG1765	OsmC-like protein
TSIB_RS03710	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
TSIB_RS03730	COG1983	PspC domain protein
TSIB_RS03760	COG0709	Synthesizes selenophosphate from selenide and ATP
TSIB_RS03765	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
TSIB_RS03780	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
TSIB_RS03790	COG0277	FAD linked oxidase domain protein
TSIB_RS03795	COG0436	Aminotransferase
TSIB_RS03800	COG2192	nodulation
TSIB_RS03890	COG0148	phosphopyruvate hydratase activity
TSIB_RS03915	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
TSIB_RS03920	COG0183	Belongs to the thiolase family
TSIB_RS03970	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
TSIB_RS03970	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
TSIB_RS03975	COG2140	Oxalate decarboxylase
TSIB_RS03980	COG1994	Peptidase M50
TSIB_RS04025	COG1522	sequence-specific DNA binding
TSIB_RS04035	COG1234	tRNA 3'-trailer cleavage
TSIB_RS04055	COG0746	molybdenum cofactor guanylyltransferase activity
TSIB_RS04075	COG0563	adenylate kinase activity
TSIB_RS04095	COG1863	multisubunit Na H antiporter MnhE subunit
TSIB_RS04100	COG2212	antiporter activity
TSIB_RS04105	COG1320	monovalent cation:proton antiporter activity
TSIB_RS04130	COG0651	ATP synthesis coupled electron transport
TSIB_RS04150	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
TSIB_RS04155	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
TSIB_RS04205	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
TSIB_RS04210	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
TSIB_RS04240	COG1444	tRNA N-acetyltransferase activity
TSIB_RS04255	COG1892	Catalyzes the irreversible beta-carboxylation of phosphoenolpyruvate (PEP) to form oxaloacetate (OAA), a four- carbon dicarboxylic acid source for the tricarboxylic acid cycle
TSIB_RS04265	COG1388	LysM domain
TSIB_RS04265	COG4641	Protein conserved in bacteria
TSIB_RS04270	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
TSIB_RS04285	COG1573	uracil-dna glycosylase
TSIB_RS04290	COG1757	Na H antiporter
TSIB_RS04300	COG1834	amidinotransferase
TSIB_RS04315	COG1793	dna ligase
TSIB_RS04365	COG0436	Aminotransferase
TSIB_RS04375	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
TSIB_RS04380	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
TSIB_RS04395	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
TSIB_RS04420	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
TSIB_RS04430	COG0235	Class ii aldolase
TSIB_RS04450	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
TSIB_RS04475	COG2078	PFAM AMMECR1 domain protein
TSIB_RS04485	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
TSIB_RS04485	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
TSIB_RS04490	COG0417	DNA replication proofreading
TSIB_RS04495	COG0563	adenylate kinase activity
TSIB_RS04545	COG2226	methyltransferase
TSIB_RS04555	COG0312	modulator of DNA gyrase
TSIB_RS04560	COG0312	modulator of DNA gyrase
TSIB_RS04565	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
TSIB_RS04620	COG1192	Involved in chromosome partitioning
TSIB_RS04635	COG0384	phenazine biosynthesis protein PhzF
TSIB_RS04645	COG1872	DUF167
TSIB_RS04655	COG0423	glycine-tRNA ligase activity
TSIB_RS04680	COG1899	peptidyl-lysine modification to peptidyl-hypusine
TSIB_RS04700	COG0303	'Molybdopterin
TSIB_RS04720	COG0525	valine-tRNA ligase activity
TSIB_RS04740	COG0501	Belongs to the peptidase M48B family
TSIB_RS04745	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
TSIB_RS04750	COG1812	S-adenosylmethionine synthetase (AdoMet synthetase)
TSIB_RS04760	COG1515	deoxyribonuclease V activity
TSIB_RS04780	COG0569	domain protein
TSIB_RS04795	COG1522	sequence-specific DNA binding
TSIB_RS04800	COG0436	Aminotransferase
TSIB_RS04810	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
TSIB_RS04840	COG0017	Asparaginyl-tRNA synthetase
TSIB_RS04855	COG0494	nUDIX hydrolase
TSIB_RS04875	COG0489	protein tyrosine kinase activity
TSIB_RS04885	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
TSIB_RS04905	COG2414	aldehyde ferredoxin oxidoreductase
TSIB_RS04910	COG1213	nucleotidyl transferase
TSIB_RS04910	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
TSIB_RS04915	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
TSIB_RS04930	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
TSIB_RS04935	COG0442	prolyl-tRNA aminoacylation
TSIB_RS04940	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
TSIB_RS04945	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
TSIB_RS04955	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
TSIB_RS04980	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
TSIB_RS04990	COG0006	proline dipeptidase activity
TSIB_RS04995	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TSIB_RS05075	COG0513	Belongs to the DEAD box helicase family
TSIB_RS05085	COG0306	phosphate transporter
TSIB_RS05110	COG0823	Involved in the tonB-independent uptake of proteins
TSIB_RS05110	COG1506	peptidase
TSIB_RS05110	COG4946	Tricorn protease homolog
TSIB_RS05125	COG0747	negative chemotaxis
TSIB_RS05130	COG0601	transmembrane transport
TSIB_RS05135	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TSIB_RS05140	COG0444	Belongs to the ABC transporter superfamily
TSIB_RS05145	COG4608	Belongs to the ABC transporter superfamily
TSIB_RS05155	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
TSIB_RS05160	COG0778	Nitroreductase
TSIB_RS05190	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
TSIB_RS05200	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TSIB_RS05200	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TSIB_RS05255	COG1132	(ABC) transporter
TSIB_RS05260	COG1132	(ABC) transporter
TSIB_RS05265	COG1051	belongs to the nudix hydrolase family
TSIB_RS05265	COG1056	cytidyltransferase-related domain
TSIB_RS05285	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
TSIB_RS05315	COG0560	Phosphoserine phosphatase
TSIB_RS05320	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
TSIB_RS05360	COG1469	GTP cyclohydrolase I activity
TSIB_RS05410	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
TSIB_RS05415	COG0733	neurotransmitter:sodium symporter activity
TSIB_RS05425	COG0347	Belongs to the P(II) protein family
TSIB_RS05430	COG1543	Belongs to the glycosyl hydrolase 57 family
TSIB_RS05435	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
TSIB_RS05440	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
TSIB_RS05445	COG0083	homoserine kinase activity
TSIB_RS05450	COG0527	aspartate kinase activity
TSIB_RS05455	COG1293	RNA-binding protein homologous to eukaryotic snRNP
TSIB_RS05510	COG2414	aldehyde ferredoxin oxidoreductase
TSIB_RS05545	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
TSIB_RS05555	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
TSIB_RS05580	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
TSIB_RS05590	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
TSIB_RS05595	COG0492	ferredoxin-NADP+ reductase activity
TSIB_RS05615	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
TSIB_RS05650	COG1254	Belongs to the acylphosphatase family
TSIB_RS05670	COG0037	tRNA processing
TSIB_RS05715	COG0095	Lipoate-protein ligase
TSIB_RS05720	COG0681	Belongs to the peptidase S26 family
TSIB_RS05745	COG0309	Hydrogenase expression formation protein (HypE)
TSIB_RS05795	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
TSIB_RS05800	COG1078	dGTPase activity
TSIB_RS05815	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
TSIB_RS05830	COG0517	IMP dehydrogenase activity
TSIB_RS05830	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
TSIB_RS05835	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
TSIB_RS05860	COG2226	methyltransferase
TSIB_RS05865	COG0667	Aldo Keto reductase
TSIB_RS05885	COG1199	ATP-dependent helicase activity
TSIB_RS05900	COG1489	DNA binding
TSIB_RS05905	COG1215	transferase activity, transferring glycosyl groups
TSIB_RS05925	COG3473	Maleate cis-trans isomerase
TSIB_RS05930	COG1355	regulation of microtubule-based process
TSIB_RS05960	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
TSIB_RS05965	COG1304	FMN binding
TSIB_RS05990	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
TSIB_RS06010	COG2233	PERMEase
TSIB_RS06015	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
TSIB_RS06020	COG1522	sequence-specific DNA binding
TSIB_RS06090	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
TSIB_RS06095	COG1122	ATPase activity
TSIB_RS06125	COG1694	Mazg nucleotide pyrophosphohydrolase
TSIB_RS06130	COG1522	sequence-specific DNA binding
TSIB_RS06155	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
TSIB_RS06165	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
TSIB_RS06170	COG0546	phosphoglycolate phosphatase activity
TSIB_RS06180	COG2131	deaminase
TSIB_RS06185	COG0501	Belongs to the peptidase M48B family
TSIB_RS06205	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
TSIB_RS06210	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
TSIB_RS06220	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TSIB_RS06225	COG0650	Formate hydrogenlyase subunit 4
TSIB_RS06235	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TSIB_RS06235	COG0649	NAD binding
TSIB_RS06240	COG3260	NADH ubiquinone oxidoreductase 20
TSIB_RS06250	COG0651	ATP synthesis coupled electron transport
TSIB_RS06255	COG1006	Multisubunit Na H antiporter MnhC subunit
TSIB_RS06260	COG2111	Na H antiporter
TSIB_RS06275	COG1320	monovalent cation:proton antiporter activity
TSIB_RS06280	COG2212	antiporter activity
TSIB_RS06295	COG0650	Formate hydrogenlyase subunit 4
TSIB_RS06305	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TSIB_RS06310	COG3260	NADH ubiquinone oxidoreductase 20
TSIB_RS06320	COG0651	ATP synthesis coupled electron transport
TSIB_RS06325	COG1006	Multisubunit Na H antiporter MnhC subunit
TSIB_RS06345	COG1320	monovalent cation:proton antiporter activity
TSIB_RS06350	COG2212	antiporter activity
TSIB_RS06355	COG1863	multisubunit Na H antiporter MnhE subunit
TSIB_RS06365	COG1968	undecaprenyl-diphosphatase activity
TSIB_RS06370	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
TSIB_RS06380	COG0517	IMP dehydrogenase activity
TSIB_RS06380	COG0516	GMP reductase activity
TSIB_RS06395	COG0310	cobalt ion transport
TSIB_RS06410	COG1122	ATPase activity
TSIB_RS06415	COG0058	SHG alpha-glucan phosphorylase activity
TSIB_RS06420	COG0528	UMP kinase activity
TSIB_RS06430	COG0733	neurotransmitter:sodium symporter activity
TSIB_RS06440	COG2119	membrane
TSIB_RS06445	COG0436	Aminotransferase
TSIB_RS06460	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
TSIB_RS06465	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
TSIB_RS06465	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
TSIB_RS06485	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TSIB_RS06485	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TSIB_RS06500	COG0359	binds to the 23S rRNA
TSIB_RS06500	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
TSIB_RS06540	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
TSIB_RS06545	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
TSIB_RS06550	COG1185	polyribonucleotide nucleotidyltransferase activity
TSIB_RS06560	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
TSIB_RS06595	COG0504	CTP synthase activity
TSIB_RS06605	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
TSIB_RS06625	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
TSIB_RS06640	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
TSIB_RS06655	COG1131	(ABC) transporter
TSIB_RS06685	COG0489	protein tyrosine kinase activity
TSIB_RS06690	COG1013	pyruvate-flavodoxin oxidoreductase activity
TSIB_RS06695	COG0674	pyruvate-flavodoxin oxidoreductase activity
TSIB_RS06705	COG1013	pyruvate-flavodoxin oxidoreductase activity
TSIB_RS06710	COG0674	pyruvate-flavodoxin oxidoreductase activity
TSIB_RS06735	COG1131	(ABC) transporter
TSIB_RS06740	COG1476	TRANSCRIPTIONal
TSIB_RS06770	COG0303	'Molybdopterin
TSIB_RS06775	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
TSIB_RS06795	COG0346	lactoylglutathione lyase activity
TSIB_RS06805	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
TSIB_RS06805	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
TSIB_RS06810	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
TSIB_RS06815	COG0424	maF-like protein
TSIB_RS06820	COG4956	integral membrane protein (PIN domain superfamily)
TSIB_RS06825	COG2894	cell division
TSIB_RS06830	COG0367	asparagine synthase
TSIB_RS06845	COG0009	L-threonylcarbamoyladenylate synthase
TSIB_RS06895	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
TSIB_RS06915	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
TSIB_RS06930	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
TSIB_RS06940	COG1522	sequence-specific DNA binding
TSIB_RS06960	COG0409	Hydrogenase expression formation protein
TSIB_RS06965	COG0298	carbon dioxide binding
TSIB_RS06970	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
TSIB_RS06995	COG1131	(ABC) transporter
TSIB_RS07010	COG0084	hydrolase, TatD family'
TSIB_RS07055	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
TSIB_RS07060	COG2267	carboxylic ester hydrolase activity
TSIB_RS07065	COG1201	RNA secondary structure unwinding
TSIB_RS07075	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
TSIB_RS07085	COG1120	ATPase activity
TSIB_RS07090	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TSIB_RS07100	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
TSIB_RS07115	COG0543	2 iron, 2 sulfur cluster binding
TSIB_RS07120	COG0493	'glutamate synthase
TSIB_RS07120	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
TSIB_RS07125	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
TSIB_RS07130	COG1013	pyruvate-flavodoxin oxidoreductase activity
TSIB_RS07135	COG0674	pyruvate-flavodoxin oxidoreductase activity
TSIB_RS07135	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
TSIB_RS07145	COG1013	pyruvate-flavodoxin oxidoreductase activity
TSIB_RS07150	COG0674	pyruvate-flavodoxin oxidoreductase activity
TSIB_RS07150	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
TSIB_RS07170	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
TSIB_RS07185	COG0516	GMP reductase activity
TSIB_RS07255	COG1518	maintenance of DNA repeat elements
TSIB_RS07265	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
TSIB_RS07270	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
TSIB_RS07305	COG0024	Methionine aminopeptidase
TSIB_RS07310	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
TSIB_RS07315	COG1122	ATPase activity
TSIB_RS07355	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
TSIB_RS07360	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
TSIB_RS07365	COG0017	Asparaginyl-tRNA synthetase
TSIB_RS07370	COG0778	Nitroreductase
TSIB_RS07430	COG0430	RNA-3'-phosphate cyclase activity
TSIB_RS07450	COG1372	Participates in initiation and elongation during chromosome replication
TSIB_RS07450	COG0305	Participates in initiation and elongation during chromosome replication
TSIB_RS07460	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
TSIB_RS07470	COG5016	pyruvate
TSIB_RS07470	COG0511	ligase activity, forming carbon-carbon bonds
TSIB_RS07475	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
TSIB_RS07480	COG0459	protein refolding
TSIB_RS07485	COG1739	Uncharacterized protein family UPF0029
TSIB_RS07510	COG2815	serine threonine protein kinase
TSIB_RS07510	COG0515	serine threonine protein kinase
TSIB_RS07515	COG1193	negative regulation of DNA recombination
TSIB_RS07520	COG0315	cyclic pyranopterin monophosphate synthase activity
TSIB_RS07525	COG0393	Putative heavy-metal-binding
TSIB_RS07575	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
TSIB_RS07580	COG0697	spore germination
TSIB_RS07595	COG0051	transcription antitermination factor activity, RNA binding
TSIB_RS07600	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
TSIB_RS07635	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
TSIB_RS07640	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
TSIB_RS07655	COG1288	antiporter activity
TSIB_RS07685	COG1573	uracil-dna glycosylase
TSIB_RS07690	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
TSIB_RS07700	COG1757	Na H antiporter
TSIB_RS07705	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
TSIB_RS07710	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
TSIB_RS07745	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
TSIB_RS07770	COG1850	ribulose-bisphosphate carboxylase activity
TSIB_RS07775	COG1435	thymidine kinase activity
TSIB_RS07790	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
TSIB_RS07795	COG0083	homoserine kinase activity
TSIB_RS07800	COG0527	aspartate kinase activity
TSIB_RS07815	COG2379	hydroxypyruvate reductase
TSIB_RS07835	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TSIB_RS07885	COG2414	aldehyde ferredoxin oxidoreductase
TSIB_RS07905	COG0574	Belongs to the PEP-utilizing enzyme family
TSIB_RS07905	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
TSIB_RS07920	COG2414	aldehyde ferredoxin oxidoreductase
TSIB_RS07930	COG2414	aldehyde ferredoxin oxidoreductase
TSIB_RS07940	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
TSIB_RS07955	COG0039	L-malate dehydrogenase activity
TSIB_RS07960	COG5441	Belongs to the UPF0261 family
TSIB_RS07965	COG3848	Pyruvate phosphate dikinase
TSIB_RS07965	COG0574	Belongs to the PEP-utilizing enzyme family
TSIB_RS07980	COG0022	dehydrogenase e1 component
TSIB_RS07985	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
TSIB_RS07995	COG0508	dehydrogenase complex catalyzes the overall conversion of
TSIB_RS08005	COG3199	ATP-NAD kinase
TSIB_RS08010	COG0095	Lipoate-protein ligase
TSIB_RS08020	COG0022	dehydrogenase e1 component
TSIB_RS08025	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
TSIB_RS08050	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
TSIB_RS08085	COG1160	GTP binding
TSIB_RS08130	COG0628	permease
TSIB_RS08135	COG1335	isochorismatase
TSIB_RS08150	COG2050	protein possibly involved in aromatic compounds catabolism
TSIB_RS08150	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
TSIB_RS08155	COG1695	Transcriptional regulator
TSIB_RS08165	COG0252	asparaginase activity
TSIB_RS08175	COG1185	polyribonucleotide nucleotidyltransferase activity
TSIB_RS08195	COG0463	Glycosyl transferase, family 2
TSIB_RS08200	COG0673	inositol 2-dehydrogenase activity
TSIB_RS08225	COG1980	fructose-bisphosphate aldolase activity
TSIB_RS08270	COG1230	cation diffusion facilitator family transporter
TSIB_RS08280	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
TSIB_RS08285	COG0798	PFAM Bile acid sodium symporter
TSIB_RS08365	COG0450	alkyl hydroperoxide reductase
TSIB_RS08385	COG0396	ATPase activity
TSIB_RS08390	COG1528	Iron-storage protein
TSIB_RS08400	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
TSIB_RS08475	COG0426	domain, Protein
TSIB_RS08485	COG1151	hydroxylamine reductase activity
TSIB_RS08535	COG0601	transmembrane transport
TSIB_RS08540	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TSIB_RS08545	COG0444	Belongs to the ABC transporter superfamily
TSIB_RS08550	COG4608	Belongs to the ABC transporter superfamily
TSIB_RS08560	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
TSIB_RS08570	COG0174	glutamine synthetase
TSIB_RS08590	COG0697	spore germination
TSIB_RS08605	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
TSIB_RS08620	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
TSIB_RS08630	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
TSIB_RS08635	COG1297	OPT oligopeptide transporter protein
TSIB_RS08645	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
TSIB_RS08655	COG1378	Sugar-specific transcriptional regulator TrmB
TSIB_RS08660	COG0297	glycogen (starch) synthase activity
TSIB_RS08670	COG0442	prolyl-tRNA aminoacylation
TSIB_RS08695	COG0482	sulfurtransferase activity
TSIB_RS08705	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
TSIB_RS08710	COG1394	ATPase activity, coupled to movement of substances
TSIB_RS08720	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
TSIB_RS08725	COG1436	Produces ATP from ADP in the presence of a proton gradient across the membrane
TSIB_RS08735	COG1390	Produces ATP from ADP in the presence of a proton gradient across the membrane
TSIB_RS08745	COG1269	ATP hydrolysis coupled proton transport
TSIB_RS08755	COG0569	domain protein
TSIB_RS08760	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
TSIB_RS08770	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
TSIB_RS08780	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
TSIB_RS08800	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
TSIB_RS08820	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
TSIB_RS08865	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
TSIB_RS08870	COG0463	Glycosyl transferase, family 2
TSIB_RS08950	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
TSIB_RS08955	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
TSIB_RS08965	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
TSIB_RS08965	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
TSIB_RS09000	COG1032	radical SAM domain protein
TSIB_RS09005	COG1510	regulation of RNA biosynthetic process
TSIB_RS09020	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
TSIB_RS09025	COG0314	molybdopterin synthase activity
TSIB_RS09040	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
TSIB_RS09045	COG1522	sequence-specific DNA binding
TSIB_RS09065	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
TSIB_RS09070	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TSIB_RS09075	COG1120	ATPase activity
TSIB_RS09090	COG1012	belongs to the aldehyde dehydrogenase family
TSIB_RS09095	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
TSIB_RS09100	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
TSIB_RS09115	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
TSIB_RS09130	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
TSIB_RS09175	COG1174	glycine betaine transport
TSIB_RS09180	COG1174	glycine betaine transport
TSIB_RS09185	COG0517	IMP dehydrogenase activity
TSIB_RS09185	COG1125	glycine betaine transport
TSIB_RS09190	COG1732	Glycine betaine
TSIB_RS09200	COG1850	ribulose-bisphosphate carboxylase activity
TSIB_RS09215	COG2033	superoxide reductase activity
TSIB_RS09220	COG1773	rubredoxin
TSIB_RS09225	COG1592	Rubrerythrin
TSIB_RS09240	COG0426	domain, Protein
TSIB_RS09245	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
TSIB_RS09250	COG1013	pyruvate-flavodoxin oxidoreductase activity
TSIB_RS09260	COG0450	alkyl hydroperoxide reductase
TSIB_RS09275	COG0649	NAD binding
TSIB_RS09280	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TSIB_RS09280	COG0649	NAD binding
TSIB_RS09285	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TSIB_RS09290	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
TSIB_RS09295	COG0651	ATP synthesis coupled electron transport
TSIB_RS09300	COG0651	ATP synthesis coupled electron transport
TSIB_RS09310	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
TSIB_RS09310	COG2111	Na H antiporter
TSIB_RS09320	COG1320	monovalent cation:proton antiporter activity
TSIB_RS09325	COG2212	antiporter activity
TSIB_RS09330	COG1863	multisubunit Na H antiporter MnhE subunit
TSIB_RS09340	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
TSIB_RS09350	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
TSIB_RS09370	COG0018	arginyl-trna synthetase
TSIB_RS09375	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
TSIB_RS09475	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
TSIB_RS09490	COG1047	Peptidyl-prolyl cis-trans
TSIB_RS09530	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
TSIB_RS09530	COG0116	Belongs to the methyltransferase superfamily
TSIB_RS09535	COG0179	Fumarylacetoacetate (FAA) hydrolase
TSIB_RS09545	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
TSIB_RS09545	COG0045	succinate-CoA ligase (ADP-forming) activity
TSIB_RS09545	COG1042	CoA-binding domain protein
TSIB_RS09550	COG0640	Transcriptional regulator
TSIB_RS09565	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
TSIB_RS09565	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
TSIB_RS09605	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
TSIB_RS09605	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
TSIB_RS09610	COG0402	S-adenosylhomocysteine deaminase activity
TSIB_RS09615	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
TSIB_RS09630	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
TSIB_RS09655	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
TSIB_RS09665	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
TSIB_RS09690	COG1028	Short-chain dehydrogenase reductase Sdr
TSIB_RS09695	COG1881	PFAM PEBP family protein
TSIB_RS09740	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
TSIB_RS09795	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
TSIB_RS09815	COG0297	glycogen (starch) synthase activity
TSIB_RS09815	COG0438	transferase activity, transferring glycosyl groups
TSIB_RS09825	COG0367	asparagine synthase
TSIB_RS09840	COG1215	transferase activity, transferring glycosyl groups
TSIB_RS09870	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
TSIB_RS09885	COG1373	ATPase (AAA superfamily
TSIB_RS09960	COG1215	transferase activity, transferring glycosyl groups
TSIB_RS10015	COG0297	glycogen (starch) synthase activity
TSIB_RS10015	COG0438	transferase activity, transferring glycosyl groups
TSIB_RS10025	COG0367	asparagine synthase
TSIB_RS10030	COG0367	asparagine synthase
TSIB_RS10035	COG0367	asparagine synthase
TSIB_RS10135	COG2813	Specifically methylates the guanine in position
TSIB_RS10170	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP