locus-tag	class	description
ADU37_RS00035	COG1346	cytolysis
ADU37_RS00055	COG0470	DNA polymerase III
ADU37_RS00055	COG1067	ATP-dependent peptidase activity
ADU37_RS00065	COG1215	transferase activity, transferring glycosyl groups
ADU37_RS00070	COG0343	queuine tRNA-ribosyltransferase activity
ADU37_RS00090	COG0433	COG0433 Predicted ATPase
ADU37_RS00095	COG0366	Alpha amylase catalytic
ADU37_RS00100	COG0456	acetyltransferase
ADU37_RS00115	COG0156	8-amino-7-oxononanoate synthase activity
ADU37_RS00120	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
ADU37_RS00125	COG2255	four-way junction helicase activity
ADU37_RS00130	COG2264	protein methyltransferase activity
ADU37_RS00140	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
ADU37_RS00150	COG1530	ribonuclease E activity
ADU37_RS00160	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
ADU37_RS00175	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
ADU37_RS00215	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
ADU37_RS00220	COG2226	methyltransferase
ADU37_RS00240	COG0281	malic enzyme
ADU37_RS00255	COG2151	metal-sulfur cluster biosynthetic enzyme
ADU37_RS00260	COG1141	Ferredoxin
ADU37_RS00295	COG0730	response to heat
ADU37_RS00300	COG1363	Peptidase, m42
ADU37_RS00340	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
ADU37_RS00350	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
ADU37_RS00355	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
ADU37_RS00380	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
ADU37_RS00385	COG2239	Acts as a magnesium transporter
ADU37_RS00395	COG2403	cyclic 2,3-diphosphoglycerate synthetase activity
ADU37_RS00400	COG0725	ABC transporter, periplasmic molybdate-binding protein
ADU37_RS00405	COG4149	molybdate abc transporter
ADU37_RS00410	COG3842	ATPase activity
ADU37_RS00425	COG1201	RNA secondary structure unwinding
ADU37_RS00440	COG1505	serine-type exopeptidase activity
ADU37_RS00445	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
ADU37_RS00460	COG1047	Peptidyl-prolyl cis-trans
ADU37_RS00465	COG0215	cysteine-tRNA ligase activity
ADU37_RS00485	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ADU37_RS00525	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
ADU37_RS00540	COG0803	Belongs to the bacterial solute-binding protein 9 family
ADU37_RS00545	COG1079	Belongs to the binding-protein-dependent transport system permease family
ADU37_RS00550	COG4603	Belongs to the binding-protein-dependent transport system permease family
ADU37_RS00555	COG3845	ABC transporter
ADU37_RS00560	COG1744	ABC transporter substrate-binding protein PnrA-like
ADU37_RS00570	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
ADU37_RS00605	COG0237	dephospho-CoA kinase activity
ADU37_RS00630	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
ADU37_RS00655	COG0432	Pfam Uncharacterised protein family UPF0047
ADU37_RS00670	COG2814	Major facilitator Superfamily
ADU37_RS00675	COG4555	ABC transporter
ADU37_RS00735	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
ADU37_RS00745	COG1695	Transcriptional regulator
ADU37_RS00760	COG0126	phosphoglycerate kinase activity
ADU37_RS00765	COG1715	Restriction endonuclease
ADU37_RS00785	COG3842	ATPase activity
ADU37_RS00815	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
ADU37_RS00830	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
ADU37_RS00830	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
ADU37_RS00835	COG1830	Aldolase
ADU37_RS00845	COG1966	Carbon starvation protein
ADU37_RS00875	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
ADU37_RS00875	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
ADU37_RS00890	COG1748	Saccharopine dehydrogenase
ADU37_RS00905	COG0010	Belongs to the arginase family
ADU37_RS00915	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
ADU37_RS00925	COG0662	Cupin 2, conserved barrel domain protein
ADU37_RS00925	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
ADU37_RS00930	COG3769	mannosylglycerate metabolic process
ADU37_RS00945	COG1793	dna ligase
ADU37_RS00945	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
ADU37_RS00950	COG0509	glycine decarboxylation via glycine cleavage system
ADU37_RS00955	COG0495	leucyl-tRNA aminoacylation
ADU37_RS00965	COG0446	pyridine nucleotide-disulphide oxidoreductase
ADU37_RS00990	COG1473	amidohydrolase
ADU37_RS01005	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
ADU37_RS01005	COG0574	Belongs to the PEP-utilizing enzyme family
ADU37_RS01010	COG0534	Mate efflux family protein
ADU37_RS01020	COG1446	asparaginase
ADU37_RS01025	COG2814	Major facilitator Superfamily
ADU37_RS01045	COG2814	Major facilitator Superfamily
ADU37_RS01060	COG1941	NADH ubiquinone oxidoreductase 20 kDa subunit
ADU37_RS01080	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
ADU37_RS01085	COG0088	Forms part of the polypeptide exit tunnel
ADU37_RS01090	COG0089	rRNA binding
ADU37_RS01095	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
ADU37_RS01100	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
ADU37_RS01105	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
ADU37_RS01110	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
ADU37_RS01115	COG0255	Belongs to the universal ribosomal protein uL29 family
ADU37_RS01130	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
ADU37_RS01135	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
ADU37_RS01140	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
ADU37_RS01150	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
ADU37_RS01160	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
ADU37_RS01165	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
ADU37_RS01180	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
ADU37_RS01185	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
ADU37_RS01195	COG0200	Binds to the 23S rRNA
ADU37_RS01220	COG1102	Psort location Cytoplasmic, score
ADU37_RS01235	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ADU37_RS01255	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
ADU37_RS01290	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
ADU37_RS01295	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
ADU37_RS01320	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
ADU37_RS01325	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
ADU37_RS01345	COG0148	phosphopyruvate hydratase activity
ADU37_RS01350	COG0052	Belongs to the universal ribosomal protein uS2 family
ADU37_RS01360	COG0301	tRNA thio-modification
ADU37_RS01375	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
ADU37_RS01415	COG1178	ABC-type Fe3 transport system permease component
ADU37_RS01425	COG4143	(ABC) transporter
ADU37_RS01455	COG0434	BtpA family
ADU37_RS01460	COG1458	PINc domain ribonuclease
ADU37_RS01490	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
ADU37_RS01505	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
ADU37_RS01510	COG0081	regulation of translation
ADU37_RS01525	COG0717	Belongs to the dCTP deaminase family
ADU37_RS01560	COG0085	RNA polymerase activity
ADU37_RS01565	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
ADU37_RS01570	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
ADU37_RS01590	COG0049	tRNA binding
ADU37_RS01595	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
ADU37_RS01615	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
ADU37_RS01620	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
ADU37_RS01675	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
ADU37_RS01680	COG2095	MarC family integral membrane protein
ADU37_RS01695	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
ADU37_RS01715	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
ADU37_RS01770	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
ADU37_RS01795	COG1418	mRNA catabolic process
ADU37_RS01805	COG0017	Asparaginyl-tRNA synthetase
ADU37_RS01820	COG0585	pseudouridine synthase activity
ADU37_RS01840	COG0543	2 iron, 2 sulfur cluster binding
ADU37_RS01845	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
ADU37_RS01850	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
ADU37_RS01855	COG0540	Belongs to the ATCase OTCase family
ADU37_RS01860	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
ADU37_RS01870	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
ADU37_RS01875	COG1522	sequence-specific DNA binding
ADU37_RS01895	COG0475	glutathione-regulated potassium exporter activity
ADU37_RS01900	COG0517	IMP dehydrogenase activity
ADU37_RS01900	COG0516	GMP reductase activity
ADU37_RS01905	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
ADU37_RS01910	COG0037	tRNA processing
ADU37_RS01915	COG1449	Belongs to the glycosyl hydrolase 57 family
ADU37_RS01950	COG0351	phosphomethylpyrimidine kinase
ADU37_RS01960	COG0352	thiamine-phosphate diphosphorylase activity
ADU37_RS01965	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
ADU37_RS01975	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
ADU37_RS01975	COG0116	Belongs to the methyltransferase superfamily
ADU37_RS01990	COG1546	Belongs to the CinA family
ADU37_RS01990	COG1058	Belongs to the CinA family
ADU37_RS01995	COG0469	pyruvate kinase activity
ADU37_RS02010	COG2414	aldehyde ferredoxin oxidoreductase
ADU37_RS02050	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
ADU37_RS02105	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
ADU37_RS02115	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
ADU37_RS02120	COG1185	polyribonucleotide nucleotidyltransferase activity
ADU37_RS02145	COG0616	signal peptide processing
ADU37_RS02170	COG1918	ferrous iron import across plasma membrane
ADU37_RS02170	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
ADU37_RS02180	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
ADU37_RS02190	COG0163	prenyltransferase activity
ADU37_RS02195	COG1522	sequence-specific DNA binding
ADU37_RS02205	COG0012	GTP binding
ADU37_RS02225	COG0534	Mate efflux family protein
ADU37_RS02230	COG1867	N(2),N(2)-dimethylguanosine tRNA methyltransferase
ADU37_RS02245	COG0071	Belongs to the small heat shock protein (HSP20) family
ADU37_RS02250	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
ADU37_RS02255	COG0693	protein deglycase activity
ADU37_RS02285	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ADU37_RS02310	COG0045	succinate-CoA ligase (ADP-forming) activity
ADU37_RS02310	COG1042	CoA-binding domain protein
ADU37_RS02310	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ADU37_RS02315	COG1110	DNA topoisomerase II activity
ADU37_RS02330	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
ADU37_RS02340	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
ADU37_RS02365	COG0105	UTP biosynthetic process
ADU37_RS02380	COG0312	modulator of DNA gyrase
ADU37_RS02385	COG0312	modulator of DNA gyrase
ADU37_RS02450	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
ADU37_RS02485	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
ADU37_RS02490	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ADU37_RS02530	COG0243	molybdopterin cofactor binding
ADU37_RS02580	COG1185	polyribonucleotide nucleotidyltransferase activity
ADU37_RS02600	COG1085	galactose-1-phosphate uridylyltransferase
ADU37_RS02605	COG2723	6-phospho-beta-galactosidase activity
ADU37_RS02620	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
ADU37_RS02625	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
ADU37_RS02630	COG4221	oxidoreductase activity
ADU37_RS02695	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ADU37_RS02700	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
ADU37_RS02730	COG0252	asparaginase activity
ADU37_RS02735	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
ADU37_RS02740	COG0733	neurotransmitter:sodium symporter activity
ADU37_RS02755	COG0528	UMP kinase activity
ADU37_RS02760	COG0058	SHG alpha-glucan phosphorylase activity
ADU37_RS02765	COG1122	ATPase activity
ADU37_RS02780	COG0310	cobalt ion transport
ADU37_RS02795	COG0516	GMP reductase activity
ADU37_RS02795	COG0517	IMP dehydrogenase activity
ADU37_RS02805	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
ADU37_RS02810	COG1968	undecaprenyl-diphosphatase activity
ADU37_RS02820	COG1863	multisubunit Na H antiporter MnhE subunit
ADU37_RS02825	COG2212	antiporter activity
ADU37_RS02830	COG1320	monovalent cation:proton antiporter activity
ADU37_RS02850	COG1006	Multisubunit Na H antiporter MnhC subunit
ADU37_RS02855	COG0651	ATP synthesis coupled electron transport
ADU37_RS02865	COG3260	NADH ubiquinone oxidoreductase 20
ADU37_RS02870	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ADU37_RS02880	COG0650	Formate hydrogenlyase subunit 4
ADU37_RS02895	COG2212	antiporter activity
ADU37_RS02900	COG1320	monovalent cation:proton antiporter activity
ADU37_RS02920	COG1006	Multisubunit Na H antiporter MnhC subunit
ADU37_RS02925	COG0651	ATP synthesis coupled electron transport
ADU37_RS02935	COG3260	NADH ubiquinone oxidoreductase 20
ADU37_RS02940	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ADU37_RS02950	COG0650	Formate hydrogenlyase subunit 4
ADU37_RS02955	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ADU37_RS02965	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
ADU37_RS02970	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ADU37_RS02990	COG0501	Belongs to the peptidase M48B family
ADU37_RS02995	COG2131	deaminase
ADU37_RS03005	COG0546	phosphoglycolate phosphatase activity
ADU37_RS03010	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
ADU37_RS03020	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
ADU37_RS03045	COG1836	PFAM Integral membrane protein DUF92
ADU37_RS03050	COG1522	sequence-specific DNA binding
ADU37_RS03055	COG1694	Mazg nucleotide pyrophosphohydrolase
ADU37_RS03080	COG1192	Involved in chromosome partitioning
ADU37_RS03085	COG2211	Major facilitator Superfamily
ADU37_RS03110	COG1872	DUF167
ADU37_RS03130	COG1131	(ABC) transporter
ADU37_RS03150	COG0423	glycine-tRNA ligase activity
ADU37_RS03170	COG1899	peptidyl-lysine modification to peptidyl-hypusine
ADU37_RS03175	COG0303	'Molybdopterin
ADU37_RS03205	COG0697	spore germination
ADU37_RS03215	COG2414	aldehyde ferredoxin oxidoreductase
ADU37_RS03250	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
ADU37_RS03265	COG1121	(ABC) transporter
ADU37_RS03280	COG1111	helicase
ADU37_RS03280	COG1205	dead DEAH box helicase
ADU37_RS03295	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
ADU37_RS03310	COG0330	HflC and HflK could
ADU37_RS03315	COG2894	cell division
ADU37_RS03340	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
ADU37_RS03360	COG0513	Belongs to the DEAD box helicase family
ADU37_RS03365	COG1342	Belongs to the UPF0251 family
ADU37_RS03375	COG0489	protein tyrosine kinase activity
ADU37_RS03455	COG0109	protoheme IX farnesyltransferase activity
ADU37_RS03465	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
ADU37_RS03470	COG0218	Necessary for normal cell division and for the maintenance of normal septation
ADU37_RS03525	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
ADU37_RS03530	COG4608	Belongs to the ABC transporter superfamily
ADU37_RS03535	COG0444	Belongs to the ABC transporter superfamily
ADU37_RS03540	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ADU37_RS03545	COG0601	transmembrane transport
ADU37_RS03555	COG2723	6-phospho-beta-galactosidase activity
ADU37_RS03630	COG1293	RNA-binding protein homologous to eukaryotic snRNP
ADU37_RS03640	COG0235	Class ii aldolase
ADU37_RS03655	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
ADU37_RS03665	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
ADU37_RS03670	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
ADU37_RS03675	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
ADU37_RS03705	COG1793	dna ligase
ADU37_RS03720	COG1757	Na H antiporter
ADU37_RS03725	COG1573	uracil-dna glycosylase
ADU37_RS03735	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
ADU37_RS03750	COG1892	Catalyzes the irreversible beta-carboxylation of phosphoenolpyruvate (PEP) to form oxaloacetate (OAA), a four- carbon dicarboxylic acid source for the tricarboxylic acid cycle
ADU37_RS03775	COG0037	tRNA processing
ADU37_RS03790	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ADU37_RS03795	COG0095	Lipoate-protein ligase
ADU37_RS03800	COG0681	Belongs to the peptidase S26 family
ADU37_RS03825	COG0482	sulfurtransferase activity
ADU37_RS03865	COG0527	aspartate kinase activity
ADU37_RS03875	COG0083	homoserine kinase activity
ADU37_RS03885	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
ADU37_RS03975	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ADU37_RS03980	COG0477	Major facilitator Superfamily
ADU37_RS03985	COG0006	proline dipeptidase activity
ADU37_RS03995	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
ADU37_RS04030	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
ADU37_RS04040	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
ADU37_RS04045	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
ADU37_RS04050	COG0442	prolyl-tRNA aminoacylation
ADU37_RS04055	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
ADU37_RS04070	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
ADU37_RS04085	COG2414	aldehyde ferredoxin oxidoreductase
ADU37_RS04105	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
ADU37_RS04115	COG0489	protein tyrosine kinase activity
ADU37_RS04130	COG0017	Asparaginyl-tRNA synthetase
ADU37_RS04135	COG0402	S-adenosylhomocysteine deaminase activity
ADU37_RS04200	COG1515	deoxyribonuclease V activity
ADU37_RS04210	COG1812	S-adenosylmethionine synthetase (AdoMet synthetase)
ADU37_RS04215	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
ADU37_RS04220	COG0501	Belongs to the peptidase M48B family
ADU37_RS04255	COG0525	valine-tRNA ligase activity
ADU37_RS04260	COG1051	belongs to the nudix hydrolase family
ADU37_RS04260	COG1056	cytidyltransferase-related domain
ADU37_RS04280	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
ADU37_RS04305	COG0560	Phosphoserine phosphatase
ADU37_RS04310	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
ADU37_RS04325	COG0175	sulfate reduction
ADU37_RS04340	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
ADU37_RS04355	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
ADU37_RS04375	COG2361	Protein of unknown function DUF86
ADU37_RS04395	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
ADU37_RS04470	COG1078	dGTPase activity
ADU37_RS04485	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
ADU37_RS04500	COG0517	IMP dehydrogenase activity
ADU37_RS04500	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
ADU37_RS04520	COG1199	ATP-dependent helicase activity
ADU37_RS04535	COG1489	DNA binding
ADU37_RS04545	COG4974	Belongs to the 'phage' integrase family
ADU37_RS04555	COG3473	Maleate cis-trans isomerase
ADU37_RS04560	COG1355	regulation of microtubule-based process
ADU37_RS04570	COG0584	glycerophosphoryl diester phosphodiesterase
ADU37_RS04580	COG0579	oxidoreductase
ADU37_RS04605	COG2339	peptidase activity
ADU37_RS04625	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
ADU37_RS04630	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
ADU37_RS04635	COG0312	modulator of DNA gyrase
ADU37_RS04650	COG0312	modulator of DNA gyrase
ADU37_RS04655	COG0493	'glutamate synthase
ADU37_RS04655	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
ADU37_RS04660	COG0543	2 iron, 2 sulfur cluster binding
ADU37_RS04690	COG1304	FMN binding
ADU37_RS04730	COG2361	Protein of unknown function DUF86
ADU37_RS04745	COG1506	peptidase
ADU37_RS04745	COG4946	Tricorn protease homolog
ADU37_RS04745	COG0823	Involved in the tonB-independent uptake of proteins
ADU37_RS04755	COG0747	negative chemotaxis
ADU37_RS04760	COG0601	transmembrane transport
ADU37_RS04765	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ADU37_RS04770	COG0444	Belongs to the ABC transporter superfamily
ADU37_RS04775	COG4608	Belongs to the ABC transporter superfamily
ADU37_RS04800	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
ADU37_RS04805	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
ADU37_RS04810	COG0066	3-isopropylmalate dehydratase activity
ADU37_RS04815	COG0473	3-isopropylmalate dehydrogenase activity
ADU37_RS04825	COG0189	ligase activity
ADU37_RS04830	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
ADU37_RS04840	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
ADU37_RS04845	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ADU37_RS04860	COG3959	Transketolase, thiamine diphosphate binding domain
ADU37_RS04865	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
ADU37_RS04870	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
ADU37_RS04875	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
ADU37_RS04880	COG0710	3-dehydroquinate dehydratase activity
ADU37_RS04885	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
ADU37_RS04905	COG1605	Chorismate mutase
ADU37_RS04905	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
ADU37_RS04910	COG0436	Aminotransferase
ADU37_RS04925	COG0133	tryptophan synthase activity
ADU37_RS04930	COG0135	phosphoribosylanthranilate isomerase activity
ADU37_RS04935	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
ADU37_RS04935	COG0512	Glutamine amidotransferase of anthranilate synthase
ADU37_RS04940	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
ADU37_RS04985	COG3885	ferrous iron binding
ADU37_RS04985	COG2078	PFAM AMMECR1 domain protein
ADU37_RS04990	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
ADU37_RS05000	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ADU37_RS05000	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ADU37_RS05010	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
ADU37_RS05040	COG2264	protein methyltransferase activity
ADU37_RS05075	COG1132	(ABC) transporter
ADU37_RS05080	COG1132	(ABC) transporter
ADU37_RS05110	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ADU37_RS05125	COG0148	phosphopyruvate hydratase activity
ADU37_RS05180	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
ADU37_RS05220	COG2192	nodulation
ADU37_RS05225	COG0436	Aminotransferase
ADU37_RS05255	COG0588	phosphoglycerate mutase activity
ADU37_RS05285	COG1765	OsmC-like protein
ADU37_RS05335	COG0864	Transcriptional regulator
ADU37_RS05345	COG0163	prenyltransferase activity
ADU37_RS05360	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
ADU37_RS05365	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
ADU37_RS05370	COG1984	allophanate hydrolase subunit 2
ADU37_RS05380	COG1454	alcohol dehydrogenase
ADU37_RS05390	COG0483	inositol monophosphate 1-phosphatase activity
ADU37_RS05410	COG1196	nuclear chromosome segregation
ADU37_RS05445	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
ADU37_RS05465	COG0011	TIGRFAM Protein of
ADU37_RS05480	COG1268	BioY protein
ADU37_RS05490	COG1122	ATPase activity
ADU37_RS05495	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
ADU37_RS05540	COG0823	Involved in the tonB-independent uptake of proteins
ADU37_RS05540	COG1506	peptidase
ADU37_RS05540	COG4946	Tricorn protease homolog
ADU37_RS05545	COG1444	tRNA N-acetyltransferase activity
ADU37_RS05565	COG1476	TRANSCRIPTIONal
ADU37_RS05570	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
ADU37_RS05575	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
ADU37_RS05610	COG2226	methyltransferase
ADU37_RS05615	COG0011	TIGRFAM Protein of
ADU37_RS05620	COG0563	adenylate kinase activity
ADU37_RS05640	COG1863	multisubunit Na H antiporter MnhE subunit
ADU37_RS05645	COG2212	antiporter activity
ADU37_RS05650	COG1320	monovalent cation:proton antiporter activity
ADU37_RS05675	COG0651	ATP synthesis coupled electron transport
ADU37_RS05695	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
ADU37_RS05700	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
ADU37_RS05725	COG1402	creatininase
ADU37_RS05735	COG0589	response to stress
ADU37_RS05825	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
ADU37_RS05835	COG2267	carboxylic ester hydrolase activity
ADU37_RS05840	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
ADU37_RS05845	COG0746	molybdenum cofactor guanylyltransferase activity
ADU37_RS05865	COG1234	tRNA 3'-trailer cleavage
ADU37_RS05880	COG1994	Peptidase M50
ADU37_RS05885	COG2140	Oxalate decarboxylase
ADU37_RS05890	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
ADU37_RS05890	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
ADU37_RS05930	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
ADU37_RS05955	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
ADU37_RS05965	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
ADU37_RS05985	COG0142	geranyltranstransferase activity
ADU37_RS05990	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
ADU37_RS06000	COG0444	Belongs to the ABC transporter superfamily
ADU37_RS06005	COG4608	Belongs to the ABC transporter superfamily
ADU37_RS06025	COG0417	DNA replication proofreading
ADU37_RS06030	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
ADU37_RS06030	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
ADU37_RS06040	COG2078	PFAM AMMECR1 domain protein
ADU37_RS06065	COG1469	GTP cyclohydrolase I activity
ADU37_RS06090	COG2205	protein histidine kinase activity
ADU37_RS06115	COG1131	(ABC) transporter
ADU37_RS06135	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
ADU37_RS06160	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
ADU37_RS06165	COG0733	neurotransmitter:sodium symporter activity
ADU37_RS06175	COG0347	Belongs to the P(II) protein family
ADU37_RS06180	COG1543	Belongs to the glycosyl hydrolase 57 family
ADU37_RS06190	COG1254	Belongs to the acylphosphatase family
ADU37_RS06220	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
ADU37_RS06240	COG0492	ferredoxin-NADP+ reductase activity
ADU37_RS06245	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
ADU37_RS06260	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
ADU37_RS06270	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
ADU37_RS06280	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
ADU37_RS06290	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ADU37_RS06345	COG1203	CRISPR-associated helicase, Cas3
ADU37_RS06360	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
ADU37_RS06370	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
ADU37_RS06390	COG2819	hydrolase of the alpha beta superfamily
ADU37_RS06395	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ADU37_RS06430	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ADU37_RS06470	COG0733	neurotransmitter:sodium symporter activity
ADU37_RS06475	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
ADU37_RS06490	COG1011	Hydrolase
ADU37_RS06500	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
ADU37_RS06515	COG0556	nucleotide-excision repair
ADU37_RS06520	COG0101	tRNA pseudouridine synthase activity
ADU37_RS06535	COG1063	alcohol dehydrogenase
ADU37_RS06545	COG2894	cell division
ADU37_RS06580	COG2119	membrane
ADU37_RS06585	COG0436	Aminotransferase
ADU37_RS06600	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
ADU37_RS06605	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
ADU37_RS06605	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
ADU37_RS06625	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ADU37_RS06625	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ADU37_RS06640	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
ADU37_RS06700	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
ADU37_RS06705	COG1185	polyribonucleotide nucleotidyltransferase activity
ADU37_RS06720	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
ADU37_RS06765	COG0504	CTP synthase activity
ADU37_RS06785	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
ADU37_RS06805	COG0312	modulator of DNA gyrase
ADU37_RS06810	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ADU37_RS06825	COG1131	(ABC) transporter
ADU37_RS06850	COG0489	protein tyrosine kinase activity
ADU37_RS06855	COG1013	pyruvate-flavodoxin oxidoreductase activity
ADU37_RS06860	COG0674	pyruvate-flavodoxin oxidoreductase activity
ADU37_RS06870	COG1013	pyruvate-flavodoxin oxidoreductase activity
ADU37_RS06875	COG0674	pyruvate-flavodoxin oxidoreductase activity
ADU37_RS06915	COG0306	phosphate transporter
ADU37_RS06925	COG1131	(ABC) transporter
ADU37_RS06930	COG1476	TRANSCRIPTIONal
ADU37_RS06950	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
ADU37_RS06965	COG0303	'Molybdopterin
ADU37_RS06970	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
ADU37_RS07000	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
ADU37_RS07020	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
ADU37_RS07020	COG0674	pyruvate-flavodoxin oxidoreductase activity
ADU37_RS07025	COG1013	pyruvate-flavodoxin oxidoreductase activity
ADU37_RS07035	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
ADU37_RS07035	COG0674	pyruvate-flavodoxin oxidoreductase activity
ADU37_RS07040	COG1013	pyruvate-flavodoxin oxidoreductase activity
ADU37_RS07045	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
ADU37_RS07060	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
ADU37_RS07075	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ADU37_RS07080	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
ADU37_RS07090	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
ADU37_RS07100	COG1201	RNA secondary structure unwinding
ADU37_RS07110	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ADU37_RS07130	COG0084	hydrolase, TatD family'
ADU37_RS07145	COG1131	(ABC) transporter
ADU37_RS07175	COG0298	carbon dioxide binding
ADU37_RS07180	COG0409	Hydrogenase expression formation protein
ADU37_RS07215	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
ADU37_RS07230	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
ADU37_RS07235	COG0477	Major facilitator Superfamily
ADU37_RS07255	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
ADU37_RS07285	COG0009	L-threonylcarbamoyladenylate synthase
ADU37_RS07290	COG0297	glycogen (starch) synthase activity
ADU37_RS07300	COG0367	asparagine synthase
ADU37_RS07310	COG2894	cell division
ADU37_RS07320	COG0424	maF-like protein
ADU37_RS07330	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
ADU37_RS07335	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
ADU37_RS07335	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
ADU37_RS07345	COG0346	lactoylglutathione lyase activity
ADU37_RS07355	COG2239	Acts as a magnesium transporter
ADU37_RS07400	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
ADU37_RS07435	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
ADU37_RS07440	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
ADU37_RS07455	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
ADU37_RS07460	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
ADU37_RS07465	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
ADU37_RS07510	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
ADU37_RS07520	COG1492	cobalamin metabolic process
ADU37_RS07525	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
ADU37_RS07530	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
ADU37_RS07545	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
ADU37_RS07555	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
ADU37_RS07560	COG0051	transcription antitermination factor activity, RNA binding
ADU37_RS07620	COG1131	(ABC) transporter
ADU37_RS07630	COG0393	Putative heavy-metal-binding
ADU37_RS07635	COG0315	cyclic pyranopterin monophosphate synthase activity
ADU37_RS07640	COG1193	negative regulation of DNA recombination
ADU37_RS07645	COG0515	serine threonine protein kinase
ADU37_RS07665	COG1739	Uncharacterized protein family UPF0029
ADU37_RS07670	COG0459	protein refolding
ADU37_RS07675	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
ADU37_RS07680	COG5016	pyruvate
ADU37_RS07680	COG0511	ligase activity, forming carbon-carbon bonds
ADU37_RS07690	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
ADU37_RS07720	COG0430	RNA-3'-phosphate cyclase activity
ADU37_RS07745	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
ADU37_RS07765	COG0543	2 iron, 2 sulfur cluster binding
ADU37_RS07770	COG0493	'glutamate synthase
ADU37_RS07770	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
ADU37_RS07775	COG0778	Nitroreductase
ADU37_RS07780	COG0017	Asparaginyl-tRNA synthetase
ADU37_RS07785	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
ADU37_RS07790	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
ADU37_RS07830	COG1122	ATPase activity
ADU37_RS07835	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
ADU37_RS07840	COG0024	Methionine aminopeptidase
ADU37_RS07850	COG0309	Hydrogenase expression formation protein (HypE)
ADU37_RS07855	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
ADU37_RS07885	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ADU37_RS07890	COG1435	thymidine kinase activity
ADU37_RS07900	COG2379	hydroxypyruvate reductase
ADU37_RS07925	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ADU37_RS07930	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
ADU37_RS08025	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
ADU37_RS08035	COG0519	Catalyzes the synthesis of GMP from XMP
ADU37_RS08035	COG0518	GMP synthase (glutamine-hydrolyzing) activity
ADU37_RS08050	COG0252	asparaginase activity
ADU37_RS08060	COG1695	Transcriptional regulator
ADU37_RS08070	COG2050	protein possibly involved in aromatic compounds catabolism
ADU37_RS08070	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
ADU37_RS08085	COG1335	isochorismatase
ADU37_RS08090	COG0628	permease
ADU37_RS08155	COG1980	fructose-bisphosphate aldolase activity
ADU37_RS08180	COG1230	cation diffusion facilitator family transporter
ADU37_RS08200	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
ADU37_RS08205	COG0798	PFAM Bile acid sodium symporter
ADU37_RS08240	COG2226	methyltransferase
ADU37_RS08275	COG4555	ABC transporter
ADU37_RS08295	COG4555	ABC transporter
ADU37_RS08350	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
ADU37_RS08385	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ADU37_RS08395	COG2608	mercury ion transmembrane transporter activity
ADU37_RS08445	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
ADU37_RS08465	COG0450	alkyl hydroperoxide reductase
ADU37_RS08480	COG1404	Belongs to the peptidase S8 family
ADU37_RS08485	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
ADU37_RS08490	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
ADU37_RS08500	COG0719	Fe-S assembly protein
ADU37_RS08510	COG0396	ATPase activity
ADU37_RS08530	COG1528	Iron-storage protein
ADU37_RS08545	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
ADU37_RS08550	COG2084	Dehydrogenase
ADU37_RS08555	COG0778	Nitroreductase
ADU37_RS08565	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
ADU37_RS08570	COG1203	CRISPR-associated helicase, Cas3
ADU37_RS08625	COG1337	RAMP superfamily
ADU37_RS08635	COG1353	crispr-associated protein
ADU37_RS08730	COG0426	domain, Protein
ADU37_RS08775	COG1151	hydroxylamine reductase activity
ADU37_RS08800	COG0459	protein refolding
ADU37_RS08830	COG0601	transmembrane transport
ADU37_RS08835	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ADU37_RS08840	COG0444	Belongs to the ABC transporter superfamily
ADU37_RS08845	COG4608	Belongs to the ABC transporter superfamily
ADU37_RS08855	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
ADU37_RS08865	COG0174	glutamine synthetase
ADU37_RS08900	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
ADU37_RS08925	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
ADU37_RS08935	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ADU37_RS08940	COG1297	OPT oligopeptide transporter protein
ADU37_RS08945	COG1234	tRNA 3'-trailer cleavage
ADU37_RS08950	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
ADU37_RS08960	COG3842	ATPase activity
ADU37_RS08970	COG3833	ABC-type maltose transport systems, permease component
ADU37_RS08980	COG2182	Extracellular solute-binding protein
ADU37_RS08990	COG1378	Sugar-specific transcriptional regulator TrmB
ADU37_RS08995	COG0297	glycogen (starch) synthase activity
ADU37_RS09005	COG0442	prolyl-tRNA aminoacylation
ADU37_RS09020	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ADU37_RS09055	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
ADU37_RS09060	COG1394	ATPase activity, coupled to movement of substances
ADU37_RS09070	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
ADU37_RS09085	COG1390	Produces ATP from ADP in the presence of a proton gradient across the membrane
ADU37_RS09095	COG1269	ATP hydrolysis coupled proton transport
ADU37_RS09105	COG0569	domain protein
ADU37_RS09110	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ADU37_RS09120	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
ADU37_RS09130	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
ADU37_RS09185	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
ADU37_RS09195	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
ADU37_RS09235	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
ADU37_RS09240	COG0463	Glycosyl transferase, family 2
ADU37_RS09285	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ADU37_RS09310	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
ADU37_RS09315	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
ADU37_RS09325	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
ADU37_RS09325	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
ADU37_RS09350	COG1510	regulation of RNA biosynthetic process
ADU37_RS09365	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
ADU37_RS09370	COG0314	molybdopterin synthase activity
ADU37_RS09380	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
ADU37_RS09420	COG0557	exoribonuclease II activity
ADU37_RS09425	COG1012	belongs to the aldehyde dehydrogenase family
ADU37_RS09450	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
ADU37_RS09485	COG0668	transmembrane transport
ADU37_RS09495	COG1215	transferase activity, transferring glycosyl groups
ADU37_RS09530	COG1028	Short-chain dehydrogenase reductase Sdr
ADU37_RS09545	COG1174	glycine betaine transport
ADU37_RS09550	COG1125	glycine betaine transport
ADU37_RS09550	COG0517	IMP dehydrogenase activity
ADU37_RS09555	COG1732	Glycine betaine
ADU37_RS09565	COG1850	ribulose-bisphosphate carboxylase activity
ADU37_RS09575	COG2033	superoxide reductase activity
ADU37_RS09580	COG1773	rubredoxin
ADU37_RS09585	COG1592	Rubrerythrin
ADU37_RS09610	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
ADU37_RS09615	COG1013	pyruvate-flavodoxin oxidoreductase activity
ADU37_RS09625	COG0450	alkyl hydroperoxide reductase
ADU37_RS09640	COG0649	NAD binding
ADU37_RS09645	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ADU37_RS09650	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
ADU37_RS09655	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
ADU37_RS09660	COG0651	ATP synthesis coupled electron transport
ADU37_RS09665	COG0651	ATP synthesis coupled electron transport
ADU37_RS09675	COG2111	Na H antiporter
ADU37_RS09675	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
ADU37_RS09685	COG1320	monovalent cation:proton antiporter activity
ADU37_RS09690	COG2212	antiporter activity
ADU37_RS09695	COG1863	multisubunit Na H antiporter MnhE subunit
ADU37_RS09705	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
ADU37_RS09715	COG1401	restriction endodeoxyribonuclease activity
ADU37_RS09745	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
ADU37_RS09780	COG0018	arginyl-trna synthetase
ADU37_RS09785	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
ADU37_RS09870	COG0714	Associated with various cellular activities
ADU37_RS09890	COG1047	Peptidyl-prolyl cis-trans
ADU37_RS09930	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
ADU37_RS09930	COG0116	Belongs to the methyltransferase superfamily
ADU37_RS09935	COG0179	Fumarylacetoacetate (FAA) hydrolase
ADU37_RS09985	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
ADU37_RS09985	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
ADU37_RS10000	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
ADU37_RS10000	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
ADU37_RS10005	COG0402	S-adenosylhomocysteine deaminase activity
ADU37_RS10010	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
ADU37_RS10050	COG2274	protein secretion by the type I secretion system
ADU37_RS10055	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
ADU37_RS10080	COG1122	ATPase activity
ADU37_RS10105	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
ADU37_RS10115	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
ADU37_RS10140	COG1028	Short-chain dehydrogenase reductase Sdr
ADU37_RS10145	COG1881	PFAM PEBP family protein
ADU37_RS10175	COG0475	glutathione-regulated potassium exporter activity
ADU37_RS10180	COG1522	sequence-specific DNA binding
ADU37_RS10205	COG0647	UMP catabolic process
ADU37_RS10225	COG0463	Glycosyl transferase, family 2
ADU37_RS10240	COG1442	glycosyl transferase family 8
ADU37_RS10240	COG1216	Glycosyl transferase, family 2
ADU37_RS10270	COG2002	toxin-antitoxin pair type II binding
ADU37_RS10290	COG0438	transferase activity, transferring glycosyl groups
ADU37_RS10335	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
ADU37_RS10365	COG1442	glycosyl transferase family 8
ADU37_RS10365	COG1216	Glycosyl transferase, family 2
ADU37_RS10375	COG0438	transferase activity, transferring glycosyl groups
ADU37_RS10390	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
ADU37_RS10405	COG0539	negative regulation of cytoplasmic translation
ADU37_RS10430	COG2890	protein-(glutamine-N5) methyltransferase activity
ADU37_RS10500	COG0519	Catalyzes the synthesis of GMP from XMP
ADU37_RS10500	COG0518	GMP synthase (glutamine-hydrolyzing) activity
ADU37_RS10510	COG0518	GMP synthase (glutamine-hydrolyzing) activity
ADU37_RS10510	COG0519	Catalyzes the synthesis of GMP from XMP
ADU37_RS10515	COG0516	GMP reductase activity
ADU37_RS10515	COG0517	IMP dehydrogenase activity
ADU37_RS10530	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
ADU37_RS10540	COG1635	Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur
ADU37_RS10550	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
ADU37_RS10565	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
ADU37_RS10570	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
ADU37_RS10570	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
ADU37_RS10575	COG0307	riboflavin synthase, alpha
ADU37_RS10580	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ADU37_RS10580	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ADU37_RS10590	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
ADU37_RS10595	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
ADU37_RS10600	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
ADU37_RS10655	COG2271	Major facilitator Superfamily
ADU37_RS10725	COG0047	phosphoribosylformylglycinamidine synthase activity
ADU37_RS10735	COG1132	(ABC) transporter
ADU37_RS10745	COG0151	Belongs to the GarS family
ADU37_RS10785	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
ADU37_RS10790	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
ADU37_RS10795	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
ADU37_RS10800	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
ADU37_RS10805	COG3383	formate dehydrogenase (NAD+) activity
ADU37_RS10830	COG0668	transmembrane transport
ADU37_RS10855	COG1695	Transcriptional regulator
ADU37_RS10880	COG2813	Specifically methylates the guanine in position
ADU37_RS11030	COG0641	radical SAM