locus-tag	class	description
TAM4_RS00015	COG2264	protein methyltransferase activity
TAM4_RS00050	COG0525	valine-tRNA ligase activity
TAM4_RS00075	COG0012	GTP binding
TAM4_RS00090	COG0018	arginyl-trna synthetase
TAM4_RS00115	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
TAM4_RS00125	COG1863	multisubunit Na H antiporter MnhE subunit
TAM4_RS00130	COG2212	antiporter activity
TAM4_RS00135	COG1320	monovalent cation:proton antiporter activity
TAM4_RS00145	COG2111	Na H antiporter
TAM4_RS00145	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
TAM4_RS00150	COG1006	Multisubunit Na H antiporter MnhC subunit
TAM4_RS00155	COG0651	ATP synthesis coupled electron transport
TAM4_RS00160	COG0651	ATP synthesis coupled electron transport
TAM4_RS00170	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TAM4_RS00180	COG0649	NAD binding
TAM4_RS00210	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
TAM4_RS00225	COG0517	IMP dehydrogenase activity
TAM4_RS00225	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
TAM4_RS00230	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
TAM4_RS00240	COG2403	cyclic 2,3-diphosphoglycerate synthetase activity
TAM4_RS00255	COG0017	Asparaginyl-tRNA synthetase
TAM4_RS00260	COG0402	S-adenosylhomocysteine deaminase activity
TAM4_RS00265	COG0516	GMP reductase activity
TAM4_RS00265	COG0517	IMP dehydrogenase activity
TAM4_RS00270	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
TAM4_RS00310	COG0656	L-ascorbic acid biosynthetic process
TAM4_RS00345	COG0045	succinate-CoA ligase (ADP-forming) activity
TAM4_RS00345	COG1042	CoA-binding domain protein
TAM4_RS00345	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
TAM4_RS00360	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
TAM4_RS00415	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
TAM4_RS00430	COG0151	Belongs to the GarS family
TAM4_RS00455	COG0047	phosphoribosylformylglycinamidine synthase activity
TAM4_RS00460	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
TAM4_RS00475	COG0516	GMP reductase activity
TAM4_RS00475	COG0517	IMP dehydrogenase activity
TAM4_RS00480	COG0519	Catalyzes the synthesis of GMP from XMP
TAM4_RS00480	COG0518	GMP synthase (glutamine-hydrolyzing) activity
TAM4_RS00495	COG0519	Catalyzes the synthesis of GMP from XMP
TAM4_RS00495	COG0518	GMP synthase (glutamine-hydrolyzing) activity
TAM4_RS00560	COG2379	hydroxypyruvate reductase
TAM4_RS00600	COG1832	CoA-binding protein
TAM4_RS00620	COG0432	Pfam Uncharacterised protein family UPF0047
TAM4_RS00740	COG1185	polyribonucleotide nucleotidyltransferase activity
TAM4_RS00755	COG0310	cobalt ion transport
TAM4_RS00760	COG0310	cobalt ion transport
TAM4_RS00770	COG1122	ATPase activity
TAM4_RS00800	COG0561	phosphatase activity
TAM4_RS00815	COG1120	ATPase activity
TAM4_RS00840	COG1151	hydroxylamine reductase activity
TAM4_RS00845	COG1141	Ferredoxin
TAM4_RS00850	COG0493	'glutamate synthase
TAM4_RS00850	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
TAM4_RS00885	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
TAM4_RS00915	COG0024	Methionine aminopeptidase
TAM4_RS00920	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
TAM4_RS00960	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
TAM4_RS00970	COG0428	transporter
TAM4_RS00985	COG1111	helicase
TAM4_RS00985	COG1205	dead DEAH box helicase
TAM4_RS00995	COG4608	Belongs to the ABC transporter superfamily
TAM4_RS01000	COG0444	Belongs to the ABC transporter superfamily
TAM4_RS01005	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TAM4_RS01010	COG0601	transmembrane transport
TAM4_RS01015	COG0747	negative chemotaxis
TAM4_RS01070	COG0543	2 iron, 2 sulfur cluster binding
TAM4_RS01075	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
TAM4_RS01075	COG0493	'glutamate synthase
TAM4_RS01095	COG0509	glycine decarboxylation via glycine cleavage system
TAM4_RS01105	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
TAM4_RS01155	COG1515	deoxyribonuclease V activity
TAM4_RS01165	COG0252	asparaginase activity
TAM4_RS01180	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
TAM4_RS01190	COG1215	transferase activity, transferring glycosyl groups
TAM4_RS01215	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
TAM4_RS01220	COG1373	ATPase (AAA superfamily
TAM4_RS01230	COG0312	modulator of DNA gyrase
TAM4_RS01245	COG1506	peptidase
TAM4_RS01245	COG0823	Involved in the tonB-independent uptake of proteins
TAM4_RS01245	COG4946	Tricorn protease homolog
TAM4_RS01285	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
TAM4_RS01300	COG0011	TIGRFAM Protein of
TAM4_RS01315	COG1966	Carbon starvation protein
TAM4_RS01350	COG2267	carboxylic ester hydrolase activity
TAM4_RS01370	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
TAM4_RS01380	COG1476	TRANSCRIPTIONal
TAM4_RS01425	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
TAM4_RS01455	COG0515	serine threonine protein kinase
TAM4_RS01455	COG2815	serine threonine protein kinase
TAM4_RS01475	COG0515	serine threonine protein kinase
TAM4_RS01475	COG2815	serine threonine protein kinase
TAM4_RS01485	COG2815	serine threonine protein kinase
TAM4_RS01485	COG0515	serine threonine protein kinase
TAM4_RS01495	COG2815	serine threonine protein kinase
TAM4_RS01495	COG0515	serine threonine protein kinase
TAM4_RS01530	COG2815	serine threonine protein kinase
TAM4_RS01530	COG0515	serine threonine protein kinase
TAM4_RS01550	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
TAM4_RS01555	COG1522	sequence-specific DNA binding
TAM4_RS01565	COG2234	aminopeptidase activity
TAM4_RS01580	COG0560	Phosphoserine phosphatase
TAM4_RS01630	COG0668	transmembrane transport
TAM4_RS01635	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
TAM4_RS01650	COG0515	serine threonine protein kinase
TAM4_RS01660	COG0501	Belongs to the peptidase M48B family
TAM4_RS01665	COG3842	ATPase activity
TAM4_RS01670	COG1178	ABC-type Fe3 transport system permease component
TAM4_RS01680	COG1028	Short-chain dehydrogenase reductase Sdr
TAM4_RS01685	COG0493	'glutamate synthase
TAM4_RS01690	COG1899	peptidyl-lysine modification to peptidyl-hypusine
TAM4_RS01720	COG0315	cyclic pyranopterin monophosphate synthase activity
TAM4_RS01730	COG1193	negative regulation of DNA recombination
TAM4_RS01735	COG0534	Mate efflux family protein
TAM4_RS01760	COG0534	Mate efflux family protein
TAM4_RS01765	COG0534	Mate efflux family protein
TAM4_RS01780	COG0574	Belongs to the PEP-utilizing enzyme family
TAM4_RS01780	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
TAM4_RS01785	COG1404	Belongs to the peptidase S8 family
TAM4_RS01810	COG0446	pyridine nucleotide-disulphide oxidoreductase
TAM4_RS01815	COG0442	prolyl-tRNA aminoacylation
TAM4_RS01820	COG2192	nodulation
TAM4_RS01825	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
TAM4_RS01830	COG0051	transcription antitermination factor activity, RNA binding
TAM4_RS01840	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
TAM4_RS01845	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
TAM4_RS01855	COG1765	OsmC-like protein
TAM4_RS01860	COG2095	MarC family integral membrane protein
TAM4_RS01900	COG0693	protein deglycase activity
TAM4_RS01915	COG0546	phosphoglycolate phosphatase activity
TAM4_RS01925	COG2131	deaminase
TAM4_RS01930	COG0501	Belongs to the peptidase M48B family
TAM4_RS01940	COG0436	Aminotransferase
TAM4_RS01945	COG2140	Oxalate decarboxylase
TAM4_RS01950	COG1994	Peptidase M50
TAM4_RS01965	COG1234	tRNA 3'-trailer cleavage
TAM4_RS01985	COG3842	ATPase activity
TAM4_RS01990	COG1178	ABC-type Fe3 transport system permease component
TAM4_RS02000	COG1121	(ABC) transporter
TAM4_RS02010	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
TAM4_RS02030	COG0006	proline dipeptidase activity
TAM4_RS02065	COG0631	protein serine/threonine phosphatase activity
TAM4_RS02070	COG0482	sulfurtransferase activity
TAM4_RS02080	COG1918	ferrous iron import across plasma membrane
TAM4_RS02080	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
TAM4_RS02090	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
TAM4_RS02100	COG0163	prenyltransferase activity
TAM4_RS02105	COG1522	sequence-specific DNA binding
TAM4_RS02175	COG1131	(ABC) transporter
TAM4_RS02180	COG1476	TRANSCRIPTIONal
TAM4_RS02235	COG1335	isochorismatase
TAM4_RS02265	COG1739	Uncharacterized protein family UPF0029
TAM4_RS02290	COG1129	ABC transporter
TAM4_RS02295	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
TAM4_RS02310	COG0306	phosphate transporter
TAM4_RS02340	COG2894	cell division
TAM4_RS02345	COG1063	alcohol dehydrogenase
TAM4_RS02365	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
TAM4_RS02375	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
TAM4_RS02380	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
TAM4_RS02430	COG1056	cytidyltransferase-related domain
TAM4_RS02430	COG1051	belongs to the nudix hydrolase family
TAM4_RS02445	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
TAM4_RS02455	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
TAM4_RS02495	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
TAM4_RS02505	COG1518	maintenance of DNA repeat elements
TAM4_RS02610	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
TAM4_RS02625	COG0778	Nitroreductase
TAM4_RS02660	COG1215	transferase activity, transferring glycosyl groups
TAM4_RS02670	COG0668	transmembrane transport
TAM4_RS02685	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
TAM4_RS02685	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
TAM4_RS02690	COG0307	riboflavin synthase, alpha
TAM4_RS02695	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
TAM4_RS02695	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
TAM4_RS02700	COG0243	molybdopterin cofactor binding
TAM4_RS02705	COG0450	alkyl hydroperoxide reductase
TAM4_RS02710	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
TAM4_RS02725	COG0651	ATP synthesis coupled electron transport
TAM4_RS02730	COG1863	multisubunit Na H antiporter MnhE subunit
TAM4_RS02735	COG1006	Multisubunit Na H antiporter MnhC subunit
TAM4_RS02750	COG1320	monovalent cation:proton antiporter activity
TAM4_RS02760	COG0651	ATP synthesis coupled electron transport
TAM4_RS02765	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
TAM4_RS02770	COG0142	geranyltranstransferase activity
TAM4_RS02795	COG0446	pyridine nucleotide-disulphide oxidoreductase
TAM4_RS02810	COG1294	oxidase, subunit
TAM4_RS02815	COG0535	radical SAM domain protein
TAM4_RS02820	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
TAM4_RS02830	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TAM4_RS02840	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
TAM4_RS02845	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
TAM4_RS02865	COG2226	methyltransferase
TAM4_RS02880	COG1528	Iron-storage protein
TAM4_RS02950	COG0426	domain, Protein
TAM4_RS02955	COG1592	Rubrerythrin
TAM4_RS02975	COG0735	belongs to the Fur family
TAM4_RS02985	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
TAM4_RS03015	COG0006	proline dipeptidase activity
TAM4_RS03030	COG1773	rubredoxin
TAM4_RS03035	COG2033	superoxide reductase activity
TAM4_RS03060	COG0084	hydrolase, TatD family'
TAM4_RS03075	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TAM4_RS03090	COG1122	ATPase activity
TAM4_RS03110	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
TAM4_RS03110	COG1042	CoA-binding domain protein
TAM4_RS03110	COG0045	succinate-CoA ligase (ADP-forming) activity
TAM4_RS03160	COG0482	sulfurtransferase activity
TAM4_RS03165	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
TAM4_RS03190	COG2247	cell wall binding repeat
TAM4_RS03190	COG0860	N-Acetylmuramoyl-L-alanine amidase
TAM4_RS03200	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
TAM4_RS03210	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
TAM4_RS03220	COG1487	ribonuclease activity
TAM4_RS03225	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
TAM4_RS03230	COG1984	allophanate hydrolase subunit 2
TAM4_RS03245	COG1473	amidohydrolase
TAM4_RS03270	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
TAM4_RS03285	COG1196	nuclear chromosome segregation
TAM4_RS03330	COG0513	Belongs to the DEAD box helicase family
TAM4_RS03355	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
TAM4_RS03385	COG1078	dGTPase activity
TAM4_RS03395	COG0126	phosphoglycerate kinase activity
TAM4_RS03405	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
TAM4_RS03410	COG0019	diaminopimelate decarboxylase activity
TAM4_RS03420	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
TAM4_RS03435	COG0602	queuosine metabolic process
TAM4_RS03470	COG0436	Aminotransferase
TAM4_RS03475	COG2050	protein possibly involved in aromatic compounds catabolism
TAM4_RS03475	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
TAM4_RS03480	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TAM4_RS03500	COG1444	tRNA N-acetyltransferase activity
TAM4_RS03520	COG1794	racemase activity, acting on amino acids and derivatives
TAM4_RS03545	COG1011	Hydrolase
TAM4_RS03600	COG1794	racemase activity, acting on amino acids and derivatives
TAM4_RS03605	COG2096	Adenosyltransferase
TAM4_RS03650	COG2409	Drug exporters of the RND superfamily
TAM4_RS03680	COG1363	Peptidase, m42
TAM4_RS03685	COG0720	synthase
TAM4_RS03725	COG1013	pyruvate-flavodoxin oxidoreductase activity
TAM4_RS03730	COG0674	pyruvate-flavodoxin oxidoreductase activity
TAM4_RS03730	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
TAM4_RS03760	COG1013	pyruvate-flavodoxin oxidoreductase activity
TAM4_RS03765	COG0674	pyruvate-flavodoxin oxidoreductase activity
TAM4_RS03765	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
TAM4_RS03800	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
TAM4_RS03820	COG1867	N(2),N(2)-dimethylguanosine tRNA methyltransferase
TAM4_RS03855	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
TAM4_RS03860	COG1078	dGTPase activity
TAM4_RS03880	COG1979	alcohol dehydrogenase
TAM4_RS03905	COG0483	inositol monophosphate 1-phosphatase activity
TAM4_RS03915	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
TAM4_RS03925	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
TAM4_RS03930	COG2271	Major facilitator Superfamily
TAM4_RS03955	COG1446	asparaginase
TAM4_RS03975	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TAM4_RS03975	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TAM4_RS04020	COG2205	protein histidine kinase activity
TAM4_RS04045	COG1469	GTP cyclohydrolase I activity
TAM4_RS04050	COG1160	GTP binding
TAM4_RS04070	COG0725	ABC transporter, periplasmic molybdate-binding protein
TAM4_RS04075	COG4208	sulfate ABC transporter
TAM4_RS04080	COG3842	ATPase activity
TAM4_RS04090	COG0303	'Molybdopterin
TAM4_RS04095	COG0521	Mo-molybdopterin cofactor biosynthetic process
TAM4_RS04105	COG0252	asparaginase activity
TAM4_RS04115	COG1695	Transcriptional regulator
TAM4_RS04130	COG1136	(ABC) transporter
TAM4_RS04150	COG0011	TIGRFAM Protein of
TAM4_RS04155	COG2078	PFAM AMMECR1 domain protein
TAM4_RS04160	COG1136	(ABC) transporter
TAM4_RS04170	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
TAM4_RS04170	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
TAM4_RS04185	COG0417	DNA replication proofreading
TAM4_RS04205	COG1185	polyribonucleotide nucleotidyltransferase activity
TAM4_RS04285	COG3473	Maleate cis-trans isomerase
TAM4_RS04300	COG0301	tRNA thio-modification
TAM4_RS04310	COG0301	tRNA thio-modification
TAM4_RS04340	COG0359	binds to the 23S rRNA
TAM4_RS04340	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
TAM4_RS04400	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
TAM4_RS04400	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
TAM4_RS04440	COG0546	phosphoglycolate phosphatase activity
TAM4_RS04450	COG0714	Associated with various cellular activities
TAM4_RS04475	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
TAM4_RS04480	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
TAM4_RS04525	COG2198	Histidine kinase
TAM4_RS04525	COG0643	Histidine kinase
TAM4_RS04530	COG2201	protein-glutamate methylesterase activity
TAM4_RS04535	COG2264	protein methyltransferase activity
TAM4_RS04600	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
TAM4_RS04615	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
TAM4_RS04640	COG0215	cysteine-tRNA ligase activity
TAM4_RS04660	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
TAM4_RS04675	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
TAM4_RS04675	COG0517	IMP dehydrogenase activity
TAM4_RS04685	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
TAM4_RS04710	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
TAM4_RS04735	COG2814	Major facilitator Superfamily
TAM4_RS04750	COG1201	RNA secondary structure unwinding
TAM4_RS04760	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
TAM4_RS04810	COG0456	acetyltransferase
TAM4_RS04825	COG0312	modulator of DNA gyrase
TAM4_RS04875	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
TAM4_RS04885	COG0131	Imidazoleglycerol-phosphate dehydratase
TAM4_RS04890	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
TAM4_RS04895	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
TAM4_RS04900	COG0107	imidazoleglycerol-phosphate synthase activity
TAM4_RS04905	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
TAM4_RS04905	COG0140	phosphoribosyl-ATP diphosphatase activity
TAM4_RS04910	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
TAM4_RS04920	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
TAM4_RS04940	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
TAM4_RS04950	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
TAM4_RS04975	COG1744	ABC transporter substrate-binding protein PnrA-like
TAM4_RS04980	COG3845	ABC transporter
TAM4_RS04985	COG4603	Belongs to the binding-protein-dependent transport system permease family
TAM4_RS04990	COG1079	Belongs to the binding-protein-dependent transport system permease family
TAM4_RS05010	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
TAM4_RS05035	COG0628	permease
TAM4_RS05040	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
TAM4_RS05065	COG1131	(ABC) transporter
TAM4_RS05080	COG0556	nucleotide-excision repair
TAM4_RS05085	COG0101	tRNA pseudouridine synthase activity
TAM4_RS05095	COG0463	Glycosyl transferase, family 2
TAM4_RS05100	COG0504	CTP synthase activity
TAM4_RS05110	COG1881	PFAM PEBP family protein
TAM4_RS05125	COG1872	DUF167
TAM4_RS05130	COG1373	ATPase (AAA superfamily
TAM4_RS05145	COG2002	toxin-antitoxin pair type II binding
TAM4_RS05180	COG1993	acr, cog1993
TAM4_RS05185	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
TAM4_RS05230	COG1110	DNA topoisomerase II activity
TAM4_RS05260	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
TAM4_RS05260	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
TAM4_RS05275	COG0071	Belongs to the small heat shock protein (HSP20) family
TAM4_RS05280	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
TAM4_RS05300	COG0584	glycerophosphoryl diester phosphodiesterase
TAM4_RS05310	COG2211	Major facilitator Superfamily
TAM4_RS05315	COG2271	Major facilitator Superfamily
TAM4_RS05330	COG1131	(ABC) transporter
TAM4_RS05335	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
TAM4_RS05365	COG4149	molybdate abc transporter
TAM4_RS05370	COG3842	ATPase activity
TAM4_RS05375	COG4143	(ABC) transporter
TAM4_RS05380	COG0733	neurotransmitter:sodium symporter activity
TAM4_RS05390	COG1543	Belongs to the glycosyl hydrolase 57 family
TAM4_RS05410	COG1757	Na H antiporter
TAM4_RS05435	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
TAM4_RS05440	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
TAM4_RS05445	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
TAM4_RS05460	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
TAM4_RS05475	COG1355	regulation of microtubule-based process
TAM4_RS05490	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
TAM4_RS05500	COG1058	Belongs to the CinA family
TAM4_RS05500	COG1546	Belongs to the CinA family
TAM4_RS05505	COG2414	aldehyde ferredoxin oxidoreductase
TAM4_RS05530	COG0732	type I restriction modification DNA specificity domain
TAM4_RS05540	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
TAM4_RS05550	COG0475	glutathione-regulated potassium exporter activity
TAM4_RS05555	COG0617	tRNA 3'-terminal CCA addition
TAM4_RS05555	COG3620	sequence-specific DNA binding
TAM4_RS05555	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
TAM4_RS05560	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
TAM4_RS05565	COG0423	glycine-tRNA ligase activity
TAM4_RS05590	COG0419	ATPase involved in DNA repair
TAM4_RS05590	COG0419	ATPase involved in DNA repair
TAM4_RS05640	COG1830	Aldolase
TAM4_RS05645	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
TAM4_RS05645	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
TAM4_RS05650	COG1301	dicarboxylic acid transport
TAM4_RS05690	COG0109	protoheme IX farnesyltransferase activity
TAM4_RS05700	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
TAM4_RS05705	COG0218	Necessary for normal cell division and for the maintenance of normal septation
TAM4_RS05745	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
TAM4_RS05755	COG0058	SHG alpha-glucan phosphorylase activity
TAM4_RS05770	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
TAM4_RS05785	COG0085	RNA polymerase activity
TAM4_RS05790	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
TAM4_RS05795	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
TAM4_RS05815	COG0049	tRNA binding
TAM4_RS05835	COG1487	ribonuclease activity
TAM4_RS05850	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
TAM4_RS05870	COG2414	aldehyde ferredoxin oxidoreductase
TAM4_RS05895	COG0513	Belongs to the DEAD box helicase family
TAM4_RS05935	COG0616	signal peptide processing
TAM4_RS05940	COG0330	HflC and HflK could
TAM4_RS05945	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
TAM4_RS05955	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
TAM4_RS05960	COG1522	sequence-specific DNA binding
TAM4_RS05985	COG2358	TRAP transporter, solute receptor (TAXI family
TAM4_RS06015	COG1418	mRNA catabolic process
TAM4_RS06035	COG0017	Asparaginyl-tRNA synthetase
TAM4_RS06050	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
TAM4_RS06060	COG0585	pseudouridine synthase activity
TAM4_RS06120	COG0105	UTP biosynthetic process
TAM4_RS06140	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
TAM4_RS06145	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
TAM4_RS06195	COG1213	nucleotidyl transferase
TAM4_RS06195	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
TAM4_RS06210	COG0284	orotidine-5'-phosphate decarboxylase activity
TAM4_RS06220	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
TAM4_RS06220	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
TAM4_RS06230	COG1192	Involved in chromosome partitioning
TAM4_RS06235	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
TAM4_RS06250	COG0436	Aminotransferase
TAM4_RS06255	COG2119	membrane
TAM4_RS06270	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
TAM4_RS06275	COG0088	Forms part of the polypeptide exit tunnel
TAM4_RS06280	COG0089	rRNA binding
TAM4_RS06285	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
TAM4_RS06290	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
TAM4_RS06300	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
TAM4_RS06305	COG0255	Belongs to the universal ribosomal protein uL29 family
TAM4_RS06320	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
TAM4_RS06325	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
TAM4_RS06330	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
TAM4_RS06340	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
TAM4_RS06350	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
TAM4_RS06355	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
TAM4_RS06370	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
TAM4_RS06375	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
TAM4_RS06380	COG1841	ribosomal large subunit assembly
TAM4_RS06385	COG0200	Binds to the 23S rRNA
TAM4_RS06410	COG1102	Psort location Cytoplasmic, score
TAM4_RS06420	COG4221	oxidoreductase activity
TAM4_RS06425	COG1598	PFAM Uncharacterised protein family UPF0150
TAM4_RS06435	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
TAM4_RS06450	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
TAM4_RS06455	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
TAM4_RS06465	COG0202	RNA polymerase activity
TAM4_RS06480	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
TAM4_RS06485	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
TAM4_RS06505	COG0148	phosphopyruvate hydratase activity
TAM4_RS06510	COG0052	Belongs to the universal ribosomal protein uS2 family
TAM4_RS06555	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
TAM4_RS06560	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
TAM4_RS06575	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
TAM4_RS06590	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
TAM4_RS06600	COG1522	sequence-specific DNA binding
TAM4_RS06610	COG0303	'Molybdopterin
TAM4_RS06615	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
TAM4_RS06620	COG1373	ATPase (AAA superfamily
TAM4_RS06640	COG0009	L-threonylcarbamoyladenylate synthase
TAM4_RS06650	COG0367	asparagine synthase
TAM4_RS06660	COG2894	cell division
TAM4_RS06665	COG4956	integral membrane protein (PIN domain superfamily)
TAM4_RS06675	COG0424	maF-like protein
TAM4_RS06685	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
TAM4_RS06685	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
TAM4_RS06695	COG0346	lactoylglutathione lyase activity
TAM4_RS06720	COG0006	proline dipeptidase activity
TAM4_RS06735	COG0495	leucyl-tRNA aminoacylation
TAM4_RS06740	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
TAM4_RS06780	COG0142	geranyltranstransferase activity
TAM4_RS06795	COG1304	FMN binding
TAM4_RS06810	COG1525	nuclease
TAM4_RS06815	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
TAM4_RS06830	COG1346	cytolysis
TAM4_RS06850	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
TAM4_RS06860	COG1573	uracil-dna glycosylase
TAM4_RS06875	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
TAM4_RS06945	COG0579	oxidoreductase
TAM4_RS06995	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
TAM4_RS07010	COG2894	cell division
TAM4_RS07020	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
TAM4_RS07065	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
TAM4_RS07135	COG0543	2 iron, 2 sulfur cluster binding
TAM4_RS07185	COG0430	RNA-3'-phosphate cyclase activity
TAM4_RS07210	COG0305	Participates in initiation and elongation during chromosome replication
TAM4_RS07210	COG1372	Participates in initiation and elongation during chromosome replication
TAM4_RS07220	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
TAM4_RS07230	COG5016	pyruvate
TAM4_RS07230	COG0511	ligase activity, forming carbon-carbon bonds
TAM4_RS07235	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
TAM4_RS07240	COG0517	IMP dehydrogenase activity
TAM4_RS07240	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
TAM4_RS07245	COG0460	homoserine dehydrogenase
TAM4_RS07265	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
TAM4_RS07270	COG1185	polyribonucleotide nucleotidyltransferase activity
TAM4_RS07285	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
TAM4_RS07335	COG2226	methyltransferase
TAM4_RS07340	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
TAM4_RS07380	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
TAM4_RS07395	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
TAM4_RS07400	COG1120	ATPase activity
TAM4_RS07405	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TAM4_RS07415	COG0456	acetyltransferase
TAM4_RS07440	COG0156	8-amino-7-oxononanoate synthase activity
TAM4_RS07455	COG2255	four-way junction helicase activity
TAM4_RS07460	COG2255	four-way junction helicase activity
TAM4_RS07465	COG2361	Protein of unknown function DUF86
TAM4_RS07480	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
TAM4_RS07500	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
TAM4_RS07505	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
TAM4_RS07520	COG3885	ferrous iron binding
TAM4_RS07520	COG2078	PFAM AMMECR1 domain protein
TAM4_RS07525	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
TAM4_RS07550	COG0540	Belongs to the ATCase OTCase family
TAM4_RS07555	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
TAM4_RS07585	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
TAM4_RS07610	COG0434	BtpA family
TAM4_RS07730	COG0312	modulator of DNA gyrase
TAM4_RS07755	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
TAM4_RS07765	COG2226	methyltransferase
TAM4_RS07830	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TAM4_RS07840	COG0037	tRNA processing
TAM4_RS07845	COG1449	Belongs to the glycosyl hydrolase 57 family
TAM4_RS07865	COG0475	glutathione-regulated potassium exporter activity
TAM4_RS07880	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
TAM4_RS07915	COG1091	dTDP-4-dehydrorhamnose reductase activity
TAM4_RS07920	COG2244	polysaccharide biosynthetic process
TAM4_RS07945	COG0463	Glycosyl transferase, family 2
TAM4_RS07950	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
TAM4_RS07955	COG1210	Utp--glucose-1-phosphate uridylyltransferase
TAM4_RS07960	COG1216	Glycosyl transferase, family 2
TAM4_RS07965	COG0438	transferase activity, transferring glycosyl groups
TAM4_RS07990	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TAM4_RS08000	COG0037	tRNA processing
TAM4_RS08075	COG0650	Formate hydrogenlyase subunit 4
TAM4_RS08085	COG3261	NADH dehydrogenase
TAM4_RS08085	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
TAM4_RS08090	COG3260	NADH ubiquinone oxidoreductase 20
TAM4_RS08100	COG0651	ATP synthesis coupled electron transport
TAM4_RS08105	COG1006	Multisubunit Na H antiporter MnhC subunit
TAM4_RS08125	COG1320	monovalent cation:proton antiporter activity
TAM4_RS08130	COG2212	antiporter activity
TAM4_RS08160	COG0148	phosphopyruvate hydratase activity
TAM4_RS08190	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
TAM4_RS08210	COG0235	Class ii aldolase
TAM4_RS08220	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
TAM4_RS08225	COG0765	amino acid transport
TAM4_RS08230	COG1126	abc transporter atp-binding protein
TAM4_RS08235	COG0765	amino acid transport
TAM4_RS08240	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
TAM4_RS08270	COG0095	Lipoate-protein ligase
TAM4_RS08330	COG4946	Tricorn protease homolog
TAM4_RS08330	COG0823	Involved in the tonB-independent uptake of proteins
TAM4_RS08330	COG1506	peptidase
TAM4_RS08355	COG0306	phosphate transporter
TAM4_RS08365	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
TAM4_RS08385	COG1980	fructose-bisphosphate aldolase activity
TAM4_RS08425	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
TAM4_RS08435	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
TAM4_RS08455	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
TAM4_RS08470	COG0402	S-adenosylhomocysteine deaminase activity
TAM4_RS08480	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
TAM4_RS08490	COG1269	ATP hydrolysis coupled proton transport
TAM4_RS08500	COG1390	Produces ATP from ADP in the presence of a proton gradient across the membrane
TAM4_RS08510	COG1436	Produces ATP from ADP in the presence of a proton gradient across the membrane
TAM4_RS08515	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
TAM4_RS08530	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
TAM4_RS08540	COG0601	transmembrane transport
TAM4_RS08545	COG0482	sulfurtransferase activity
TAM4_RS08610	COG1328	CTP reductase activity
TAM4_RS08630	COG1522	sequence-specific DNA binding
TAM4_RS08635	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
TAM4_RS08655	COG0314	molybdopterin synthase activity
TAM4_RS08675	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
TAM4_RS08690	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
TAM4_RS08700	COG0492	ferredoxin-NADP+ reductase activity
TAM4_RS08710	COG2255	four-way junction helicase activity
TAM4_RS08715	COG0116	Belongs to the methyltransferase superfamily
TAM4_RS08725	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
TAM4_RS08745	COG0714	Associated with various cellular activities
TAM4_RS08765	COG1047	Peptidyl-prolyl cis-trans
TAM4_RS08800	COG1160	GTP binding
TAM4_RS08805	COG0116	Belongs to the methyltransferase superfamily
TAM4_RS08815	COG0179	Fumarylacetoacetate (FAA) hydrolase
TAM4_RS08840	COG0640	Transcriptional regulator
TAM4_RS08855	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
TAM4_RS08875	COG0180	Tryptophanyl-tRNA synthetase
TAM4_RS08890	COG0640	Transcriptional regulator
TAM4_RS08900	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
TAM4_RS08900	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
TAM4_RS08910	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
TAM4_RS08910	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
TAM4_RS08930	COG0489	protein tyrosine kinase activity
TAM4_RS08935	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TAM4_RS08950	COG0864	Transcriptional regulator
TAM4_RS08965	COG0489	protein tyrosine kinase activity
TAM4_RS09025	COG0746	molybdenum cofactor guanylyltransferase activity
TAM4_RS09040	COG3260	NADH ubiquinone oxidoreductase 20
TAM4_RS09045	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TAM4_RS09050	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
TAM4_RS09050	COG3261	NADH dehydrogenase
TAM4_RS09055	COG0650	Formate hydrogenlyase subunit 4
TAM4_RS09060	COG0651	ATP synthesis coupled electron transport
TAM4_RS09065	COG2111	Na H antiporter
TAM4_RS09065	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
TAM4_RS09075	COG3383	formate dehydrogenase (NAD+) activity
TAM4_RS09080	COG1309	transcriptional regulator
TAM4_RS09095	COG0298	carbon dioxide binding
TAM4_RS09100	COG0409	Hydrogenase expression formation protein
TAM4_RS09105	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
TAM4_RS09115	COG1895	HEPN domain
TAM4_RS09120	COG0309	Hydrogenase expression formation protein (HypE)
TAM4_RS09125	COG1013	pyruvate-flavodoxin oxidoreductase activity
TAM4_RS09130	COG0674	pyruvate-flavodoxin oxidoreductase activity
TAM4_RS09140	COG1013	pyruvate-flavodoxin oxidoreductase activity
TAM4_RS09145	COG0674	pyruvate-flavodoxin oxidoreductase activity
TAM4_RS09160	COG0306	phosphate transporter
TAM4_RS09165	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
TAM4_RS09170	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
TAM4_RS09185	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
TAM4_RS09215	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
TAM4_RS09225	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
TAM4_RS09230	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
TAM4_RS09235	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
TAM4_RS09255	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
TAM4_RS09265	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
TAM4_RS09265	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
TAM4_RS09280	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
TAM4_RS09410	COG2239	Acts as a magnesium transporter
TAM4_RS09415	COG0475	glutathione-regulated potassium exporter activity
TAM4_RS09425	COG2095	MarC family integral membrane protein
TAM4_RS09440	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
TAM4_RS09445	COG1115	amino acid carrier protein
TAM4_RS09455	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
TAM4_RS09470	COG2022	thiamine diphosphate biosynthetic process
TAM4_RS09495	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
TAM4_RS09505	COG1373	ATPase (AAA superfamily
TAM4_RS09510	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
TAM4_RS09520	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
TAM4_RS09550	COG0475	glutathione-regulated potassium exporter activity
TAM4_RS09570	COG0543	2 iron, 2 sulfur cluster binding
TAM4_RS09575	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
TAM4_RS09585	COG0601	transmembrane transport
TAM4_RS09590	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TAM4_RS09595	COG0444	Belongs to the ABC transporter superfamily
TAM4_RS09600	COG4608	Belongs to the ABC transporter superfamily
TAM4_RS09615	COG0174	glutamine synthetase
TAM4_RS09685	COG1254	Belongs to the acylphosphatase family
TAM4_RS09695	COG1628	Protein of unknown function DUF99
TAM4_RS09700	COG0589	response to stress
TAM4_RS09705	COG0404	The glycine cleavage system catalyzes the degradation of glycine
TAM4_RS09750	COG1122	ATPase activity
TAM4_RS09755	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
TAM4_RS09770	COG0167	dihydroorotate dehydrogenase activity
TAM4_RS09775	COG2515	1-aminocyclopropane-1-carboxylate deaminase
TAM4_RS09800	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
TAM4_RS09805	COG0528	UMP kinase activity
TAM4_RS09815	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
TAM4_RS09830	COG2814	Major facilitator Superfamily
TAM4_RS09835	COG1404	Belongs to the peptidase S8 family
TAM4_RS09855	COG2151	metal-sulfur cluster biosynthetic enzyme
TAM4_RS09860	COG1141	Ferredoxin
TAM4_RS09895	COG1137	ATPase activity
TAM4_RS09900	COG0719	Fe-S assembly protein
TAM4_RS09925	COG0651	ATP synthesis coupled electron transport
TAM4_RS09930	COG1863	multisubunit Na H antiporter MnhE subunit
TAM4_RS09935	COG1006	Multisubunit Na H antiporter MnhC subunit
TAM4_RS09950	COG1320	monovalent cation:proton antiporter activity
TAM4_RS09955	COG2212	antiporter activity
TAM4_RS09960	COG3260	NADH ubiquinone oxidoreductase 20
TAM4_RS09965	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TAM4_RS09970	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
TAM4_RS09970	COG3261	NADH dehydrogenase
TAM4_RS09975	COG0650	Formate hydrogenlyase subunit 4
TAM4_RS09980	COG0651	ATP synthesis coupled electron transport
TAM4_RS10000	COG1151	hydroxylamine reductase activity
TAM4_RS10005	COG0437	4 iron, 4 sulfur cluster binding
TAM4_RS10020	COG2814	Major facilitator Superfamily
TAM4_RS10070	COG0175	sulfate reduction
TAM4_RS10085	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
TAM4_RS10085	COG0493	'glutamate synthase
TAM4_RS10090	COG0543	2 iron, 2 sulfur cluster binding
TAM4_RS10195	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
TAM4_RS10210	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
TAM4_RS10210	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
TAM4_RS10225	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
TAM4_RS10230	COG1042	CoA-binding domain protein
TAM4_RS10230	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
TAM4_RS10230	COG0045	succinate-CoA ligase (ADP-forming) activity
TAM4_RS10255	COG0123	including yeast histone deacetylase and acetoin utilization protein
TAM4_RS10270	COG0010	Belongs to the arginase family
TAM4_RS10290	COG2002	toxin-antitoxin pair type II binding
TAM4_RS10295	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
TAM4_RS10305	COG1694	Mazg nucleotide pyrophosphohydrolase
TAM4_RS10315	COG0438	transferase activity, transferring glycosyl groups
TAM4_RS10395	COG0183	Belongs to the thiolase family
TAM4_RS10400	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
TAM4_RS10425	COG1522	sequence-specific DNA binding
TAM4_RS10455	COG2252	PERMEase
TAM4_RS10485	COG1458	PINc domain ribonuclease
TAM4_RS10515	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
TAM4_RS10530	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
TAM4_RS10535	COG0081	regulation of translation
TAM4_RS10550	COG0717	Belongs to the dCTP deaminase family
TAM4_RS10600	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
TAM4_RS10630	COG2264	protein methyltransferase activity
TAM4_RS10635	COG1851	Uncharacterised protein family (UPF0128)
TAM4_RS10650	COG1435	thymidine kinase activity
TAM4_RS10660	COG0330	HflC and HflK could
TAM4_RS10670	COG0175	sulfate reduction
TAM4_RS10680	COG2815	serine threonine protein kinase
TAM4_RS10680	COG0515	serine threonine protein kinase
TAM4_RS10705	COG1695	Transcriptional regulator
TAM4_RS10715	COG0393	Putative heavy-metal-binding
TAM4_RS10730	COG2264	protein methyltransferase activity
TAM4_RS10735	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
TAM4_RS10735	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
TAM4_RS10740	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
TAM4_RS10745	COG1492	cobalamin metabolic process
TAM4_RS10760	COG0746	molybdenum cofactor guanylyltransferase activity
TAM4_RS10765	COG2342	PFAM TM1410 hypothetical-related protein
TAM4_RS10780	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
TAM4_RS10810	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
TAM4_RS10815	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
TAM4_RS10830	COG1941	NADH ubiquinone oxidoreductase 20 kDa subunit
TAM4_RS10910	COG0719	Fe-S assembly protein
TAM4_RS10915	COG0396	ATPase activity
TAM4_RS10935	COG0730	response to heat
TAM4_RS10940	COG0730	response to heat
TAM4_RS10960	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
TAM4_RS10975	COG0731	radical SAM domain protein
TAM4_RS10975	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
TAM4_RS10980	COG0489	protein tyrosine kinase activity
TAM4_RS10985	COG0455	bacterial-type flagellum organization
TAM4_RS10990	COG1342	Belongs to the UPF0251 family
TAM4_RS11020	COG1812	S-adenosylmethionine synthetase (AdoMet synthetase)
TAM4_RS11050	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
TAM4_RS11120	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
TAM4_RS11125	COG4608	Belongs to the ABC transporter superfamily
TAM4_RS11130	COG0444	Belongs to the ABC transporter superfamily
TAM4_RS11140	COG0601	transmembrane transport
TAM4_RS11145	COG4166	transmembrane transport
TAM4_RS11150	COG2723	6-phospho-beta-galactosidase activity
TAM4_RS11170	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
TAM4_RS11180	COG0297	glycogen (starch) synthase activity
TAM4_RS11185	COG1378	Sugar-specific transcriptional regulator TrmB
TAM4_RS11190	COG0366	Alpha amylase catalytic
TAM4_RS11200	COG1175	transmembrane transport
TAM4_RS11205	COG3833	ABC-type maltose transport systems, permease component
TAM4_RS11215	COG3842	ATPase activity
TAM4_RS11225	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
TAM4_RS11230	COG1234	tRNA 3'-trailer cleavage
TAM4_RS11235	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
TAM4_RS11255	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
TAM4_RS11280	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
TAM4_RS11295	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
TAM4_RS11310	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
TAM4_RS11320	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
TAM4_RS11325	COG0157	Belongs to the NadC ModD family
TAM4_RS11350	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
TAM4_RS11355	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
TAM4_RS11360	COG3383	formate dehydrogenase (NAD+) activity
TAM4_RS11380	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
TAM4_RS11385	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
TAM4_RS11390	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
TAM4_RS11395	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
TAM4_RS11415	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
TAM4_RS11430	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
TAM4_RS11485	COG0631	protein serine/threonine phosphatase activity
TAM4_RS11490	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
TAM4_RS11505	COG0515	serine threonine protein kinase
TAM4_RS11505	COG2815	serine threonine protein kinase
TAM4_RS11535	COG1216	Glycosyl transferase, family 2
TAM4_RS11535	COG0463	Glycosyl transferase, family 2
TAM4_RS11570	COG2815	serine threonine protein kinase
TAM4_RS11570	COG0515	serine threonine protein kinase
TAM4_RS11590	COG1116	anion transmembrane transporter activity
TAM4_RS11620	COG2813	Specifically methylates the guanine in position