locus-tag	class	description
THAL_RS00080	COG1203	CRISPR-associated helicase, Cas3
THAL_RS00105	COG0704	Plays a role in the regulation of phosphate uptake
THAL_RS00140	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
THAL_RS00150	COG0165	Argininosuccinate lyase
THAL_RS00155	COG0037	tRNA processing
THAL_RS00160	COG0237	dephospho-CoA kinase activity
THAL_RS00165	COG0436	Aminotransferase
THAL_RS00180	COG2165	general secretion pathway protein
THAL_RS00235	COG4972	Pilus assembly protein
THAL_RS00240	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
THAL_RS00240	COG0574	Belongs to the PEP-utilizing enzyme family
THAL_RS00245	COG0751	glycine-tRNA ligase activity
THAL_RS00255	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
THAL_RS00275	COG0484	heat shock protein binding
THAL_RS00280	COG0789	Transcriptional regulator
THAL_RS00285	COG0490	domain, Protein
THAL_RS00290	COG0475	glutathione-regulated potassium exporter activity
THAL_RS00305	COG2264	protein methyltransferase activity
THAL_RS00315	COG0445	tRNA wobble uridine modification
THAL_RS00320	COG4145	pantothenate transmembrane transporter activity
THAL_RS00325	COG0315	cyclic pyranopterin monophosphate synthase activity
THAL_RS00330	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
THAL_RS00340	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
THAL_RS00345	COG0436	Aminotransferase
THAL_RS00350	COG1040	competence protein
THAL_RS00355	COG2003	Belongs to the UPF0758 family
THAL_RS00365	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
THAL_RS00375	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
THAL_RS00380	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
THAL_RS00390	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
THAL_RS00415	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
THAL_RS00420	COG0644	oxidoreductase
THAL_RS00425	COG1349	DNA-binding transcription factor activity
THAL_RS00435	COG1110	DNA topoisomerase II activity
THAL_RS00445	COG0227	Belongs to the bacterial ribosomal protein bL28 family
THAL_RS00450	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
THAL_RS00455	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
THAL_RS00470	COG0571	ribonuclease III activity
THAL_RS00475	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
THAL_RS00480	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
THAL_RS00485	COG0167	dihydroorotate dehydrogenase activity
THAL_RS00490	COG2814	Major facilitator Superfamily
THAL_RS00500	COG1538	Outer membrane efflux protein
THAL_RS00505	COG1309	transcriptional regulator
THAL_RS00520	COG0142	geranyltranstransferase activity
THAL_RS00525	COG0406	alpha-ribazole phosphatase activity
THAL_RS00530	COG0495	leucyl-tRNA aminoacylation
THAL_RS00540	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
THAL_RS00545	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
THAL_RS00570	COG0720	synthase
THAL_RS00590	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
THAL_RS00595	COG1136	(ABC) transporter
THAL_RS00600	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
THAL_RS00610	COG1546	Belongs to the CinA family
THAL_RS00610	COG1058	Belongs to the CinA family
THAL_RS00615	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
THAL_RS00625	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
THAL_RS00635	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
THAL_RS00640	COG0564	pseudouridine synthase activity
THAL_RS00645	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
THAL_RS00660	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
THAL_RS00665	COG0438	transferase activity, transferring glycosyl groups
THAL_RS00705	COG0444	Belongs to the ABC transporter superfamily
THAL_RS00725	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
THAL_RS00730	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
THAL_RS00735	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
THAL_RS00745	COG0275	rRNA processing
THAL_RS00760	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
THAL_RS00765	COG0745	RESPONSE REGULATOR receiver
THAL_RS00770	COG0218	Necessary for normal cell division and for the maintenance of normal septation
THAL_RS00775	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
THAL_RS00780	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
THAL_RS00790	COG0617	tRNA 3'-terminal CCA addition
THAL_RS00800	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
THAL_RS00800	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
THAL_RS00805	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
THAL_RS00810	COG1618	nucleotide phosphatase activity, acting on free nucleotides
THAL_RS00815	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
THAL_RS00820	COG0352	thiamine-phosphate diphosphorylase activity
THAL_RS00825	COG0133	tryptophan synthase activity
THAL_RS00830	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
THAL_RS00835	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
THAL_RS00850	COG0360	Binds together with S18 to 16S ribosomal RNA
THAL_RS00855	COG0629	single-stranded DNA binding
THAL_RS00860	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
THAL_RS00865	COG0359	binds to the 23S rRNA
THAL_RS00870	COG0667	Aldo Keto reductase
THAL_RS00875	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
THAL_RS00885	COG1496	oxidoreductase activity
THAL_RS00890	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
THAL_RS00895	COG0404	The glycine cleavage system catalyzes the degradation of glycine
THAL_RS00900	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
THAL_RS00910	COG0391	Required for morphogenesis under gluconeogenic growth conditions
THAL_RS00915	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
THAL_RS00920	COG0322	excinuclease ABC activity
THAL_RS00930	COG1872	DUF167
THAL_RS00935	COG0631	protein serine/threonine phosphatase activity
THAL_RS00940	COG0101	tRNA pseudouridine synthase activity
THAL_RS00950	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
THAL_RS00955	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
THAL_RS00965	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
THAL_RS00970	COG0590	tRNA wobble adenosine to inosine editing
THAL_RS00975	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
THAL_RS00980	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
THAL_RS00990	COG2217	Heavy metal translocating P-type atpase
THAL_RS01000	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
THAL_RS01005	COG0581	inorganic phosphate transmembrane transporter activity
THAL_RS01010	COG0573	inorganic phosphate transmembrane transporter activity
THAL_RS01020	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
THAL_RS01030	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
THAL_RS01035	COG0277	FAD linked oxidase domain protein
THAL_RS01040	COG0653	protein targeting
THAL_RS01045	COG0009	L-threonylcarbamoyladenylate synthase
THAL_RS01050	COG0193	aminoacyl-tRNA hydrolase activity
THAL_RS01055	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
THAL_RS01060	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
THAL_RS01070	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
THAL_RS01075	COG1418	mRNA catabolic process
THAL_RS01075	COG3599	regulation of cell shape
THAL_RS01080	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
THAL_RS01085	COG0072	phenylalanine-tRNA ligase activity
THAL_RS01085	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
THAL_RS01090	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
THAL_RS01095	COG1216	Glycosyl transferase, family 2
THAL_RS01100	COG1465	3-dehydroquinate synthase
THAL_RS01110	COG1924	4 iron, 4 sulfur cluster binding
THAL_RS01130	COG0095	Lipoate-protein ligase
THAL_RS01135	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
THAL_RS01150	COG0084	hydrolase, TatD family'
THAL_RS01155	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
THAL_RS01160	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
THAL_RS01170	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
THAL_RS01180	COG1157	protein secretion by the type III secretion system
THAL_RS01185	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
THAL_RS01190	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
THAL_RS01195	COG0602	queuosine metabolic process
THAL_RS01200	COG0860	N-Acetylmuramoyl-L-alanine amidase
THAL_RS01210	COG0181	hydroxymethylbilane synthase activity
THAL_RS01215	COG0736	holo-[acyl-carrier-protein] synthase activity
THAL_RS01220	COG0351	phosphomethylpyrimidine kinase
THAL_RS01225	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
THAL_RS01230	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
THAL_RS01235	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
THAL_RS01245	COG3002	Belongs to the UPF0753 family
THAL_RS01250	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
THAL_RS01255	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
THAL_RS01265	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
THAL_RS01270	COG0489	protein tyrosine kinase activity
THAL_RS01275	COG1104	cysteine desulfurase activity
THAL_RS01280	COG2389	metal-binding protein
THAL_RS01300	COG2322	membrane
THAL_RS01315	COG0439	Biotin carboxylase
THAL_RS01320	COG5016	pyruvate
THAL_RS01320	COG0511	ligase activity, forming carbon-carbon bonds
THAL_RS01325	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
THAL_RS01335	COG0285	dihydrofolate synthase activity
THAL_RS01345	COG3158	transport of potassium into the cell
THAL_RS01350	COG1793	dna ligase
THAL_RS01360	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
THAL_RS01365	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
THAL_RS01370	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
THAL_RS01370	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
THAL_RS01380	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
THAL_RS01390	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
THAL_RS01390	COG2022	thiamine diphosphate biosynthetic process
THAL_RS01395	COG0302	gtp cyclohydrolase
THAL_RS01405	COG1132	(ABC) transporter
THAL_RS01415	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
THAL_RS01415	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
THAL_RS01420	COG5002	protein histidine kinase activity
THAL_RS01425	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
THAL_RS01430	COG1053	succinate dehydrogenase
THAL_RS01435	COG0300	oxidoreductase activity
THAL_RS01450	COG0247	lactate metabolic process
THAL_RS01455	COG2814	Major facilitator Superfamily
THAL_RS01460	COG1959	2 iron, 2 sulfur cluster binding
THAL_RS01465	COG0390	transport system, permease component
THAL_RS01470	COG0803	Belongs to the bacterial solute-binding protein 9 family
THAL_RS01475	COG1121	(ABC) transporter
THAL_RS01485	COG0018	arginyl-trna synthetase
THAL_RS01500	COG0131	Imidazoleglycerol-phosphate dehydratase
THAL_RS01505	COG1466	dna polymerase III delta subunit
THAL_RS01510	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
THAL_RS01515	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
THAL_RS01525	COG4478	integral membrane protein
THAL_RS01535	COG1028	Short-chain dehydrogenase reductase Sdr
THAL_RS01540	COG1489	DNA binding
THAL_RS01545	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
THAL_RS01560	COG0587	DNA-directed DNA polymerase activity
THAL_RS01585	COG0745	RESPONSE REGULATOR receiver
THAL_RS01595	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
THAL_RS01600	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
THAL_RS01610	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
THAL_RS01615	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
THAL_RS01620	COG0658	competence protein
THAL_RS01625	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
THAL_RS01640	COG0519	Catalyzes the synthesis of GMP from XMP
THAL_RS01640	COG0518	GMP synthase (glutamine-hydrolyzing) activity
THAL_RS01655	COG4783	chaperone-mediated protein folding
THAL_RS01665	COG0316	Belongs to the HesB IscA family
THAL_RS01675	COG1702	phosphate starvation-inducible protein PhoH
THAL_RS01685	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
THAL_RS01690	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
THAL_RS01695	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
THAL_RS01700	COG0215	cysteine-tRNA ligase activity
THAL_RS01705	COG0521	Mo-molybdopterin cofactor biosynthetic process
THAL_RS01715	COG0825	malonyl-CoA metabolic process
THAL_RS01730	COG1749	Flagellar hook protein flgE
THAL_RS01750	COG0668	transmembrane transport
THAL_RS01755	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
THAL_RS01760	COG0527	aspartate kinase activity
THAL_RS01765	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
THAL_RS01765	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
THAL_RS01770	COG0792	nuclease activity
THAL_RS01775	COG1837	Belongs to the UPF0109 family
THAL_RS01780	COG0228	four-way junction DNA binding
THAL_RS01785	COG0484	heat shock protein binding
THAL_RS01795	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
THAL_RS01795	COG0517	IMP dehydrogenase activity
THAL_RS01800	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
THAL_RS01810	COG0335	large ribosomal subunit rRNA binding
THAL_RS01815	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
THAL_RS01825	COG1862	Preprotein translocase
THAL_RS01855	COG2608	mercury ion transmembrane transporter activity
THAL_RS01860	COG0746	molybdenum cofactor guanylyltransferase activity
THAL_RS01870	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
THAL_RS01875	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
THAL_RS01875	COG0649	NAD binding
THAL_RS01880	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
THAL_RS01885	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
THAL_RS01890	COG1812	S-adenosylmethionine synthetase (AdoMet synthetase)
THAL_RS01895	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
THAL_RS01900	COG0531	amino acid
THAL_RS01910	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
THAL_RS01925	COG1181	Belongs to the D-alanine--D-alanine ligase family
THAL_RS01930	COG0812	UDP-N-acetylmuramate dehydrogenase activity
THAL_RS01935	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
THAL_RS01940	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
THAL_RS01945	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
THAL_RS01975	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
THAL_RS01980	COG1454	alcohol dehydrogenase
THAL_RS02000	COG0312	modulator of DNA gyrase
THAL_RS02010	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
THAL_RS02015	COG0314	molybdopterin synthase activity
THAL_RS02020	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
THAL_RS02040	COG0347	Belongs to the P(II) protein family
THAL_RS02075	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
THAL_RS02080	COG1104	cysteine desulfurase activity
THAL_RS02085	COG2414	aldehyde ferredoxin oxidoreductase
THAL_RS02105	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
THAL_RS02110	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
THAL_RS02130	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
THAL_RS02135	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
THAL_RS02140	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
THAL_RS02160	COG0504	CTP synthase activity
THAL_RS02170	COG0247	lactate metabolic process
THAL_RS02175	COG0612	Peptidase, M16
THAL_RS02180	COG0612	Peptidase, M16
THAL_RS02200	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
THAL_RS02205	COG4942	peptidase
THAL_RS02210	COG1254	Belongs to the acylphosphatase family
THAL_RS02215	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
THAL_RS02225	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
THAL_RS02230	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
THAL_RS02240	COG1692	metallophosphoesterase
THAL_RS02245	COG0544	peptidyl-prolyl cis-trans isomerase activity
THAL_RS02250	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
THAL_RS02260	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
THAL_RS02265	COG1160	GTP binding
THAL_RS02270	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
THAL_RS02275	COG2050	protein possibly involved in aromatic compounds catabolism
THAL_RS02275	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
THAL_RS02280	COG0154	amidase activity
THAL_RS02310	COG0291	Belongs to the bacterial ribosomal protein bL35 family
THAL_RS02315	COG0194	GDP metabolic process
THAL_RS02320	COG1758	RNA polymerase activity
THAL_RS02330	COG0739	heme binding
THAL_RS02330	COG1196	nuclear chromosome segregation
THAL_RS02330	COG0741	lytic transglycosylase activity
THAL_RS02335	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
THAL_RS02350	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
THAL_RS02360	COG0436	Aminotransferase
THAL_RS02375	COG1210	Utp--glucose-1-phosphate uridylyltransferase
THAL_RS02380	COG2050	protein possibly involved in aromatic compounds catabolism
THAL_RS02380	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
THAL_RS02385	COG0135	phosphoribosylanthranilate isomerase activity
THAL_RS02400	COG0635	Involved in the biosynthesis of porphyrin-containing compound
THAL_RS02405	COG0772	Belongs to the SEDS family
THAL_RS02415	COG0457	Tetratricopeptide repeat
THAL_RS02425	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
THAL_RS02430	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
THAL_RS02435	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
THAL_RS02445	COG0124	histidyl-tRNA synthetase
THAL_RS02460	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
THAL_RS02480	COG4191	Histidine kinase
THAL_RS02505	COG0424	maF-like protein
THAL_RS02515	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
THAL_RS02525	COG0745	RESPONSE REGULATOR receiver
THAL_RS02530	COG0840	transmembrane signaling receptor activity
THAL_RS02535	COG0840	transmembrane signaling receptor activity
THAL_RS02540	COG0835	chemotaxis
THAL_RS02540	COG0784	Response regulator, receiver
THAL_RS02545	COG2198	Histidine kinase
THAL_RS02545	COG0784	Response regulator, receiver
THAL_RS02545	COG0643	Histidine kinase
THAL_RS02550	COG0835	chemotaxis
THAL_RS02565	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
THAL_RS02580	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
THAL_RS02600	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
THAL_RS02610	COG1509	lysine 2,3-aminomutase activity
THAL_RS02615	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
THAL_RS02640	COG2165	general secretion pathway protein
THAL_RS02660	COG0544	peptidyl-prolyl cis-trans isomerase activity
THAL_RS02665	COG0728	peptidoglycan biosynthetic process
THAL_RS02670	COG1136	(ABC) transporter
THAL_RS02670	COG0577	efflux transmembrane transporter activity
THAL_RS02680	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
THAL_RS02685	COG1830	Aldolase
THAL_RS02695	COG0717	Belongs to the dCTP deaminase family
THAL_RS02700	COG0544	peptidyl-prolyl cis-trans isomerase activity
THAL_RS02705	COG0137	argininosuccinate synthase activity
THAL_RS02710	COG0710	3-dehydroquinate dehydratase activity
THAL_RS02715	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
THAL_RS02720	COG1867	N(2),N(2)-dimethylguanosine tRNA methyltransferase
THAL_RS02730	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
THAL_RS02745	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
THAL_RS02750	COG0419	ATPase involved in DNA repair
THAL_RS02755	COG0420	3'-5' exonuclease activity
THAL_RS02760	COG1611	Belongs to the LOG family
THAL_RS02775	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
THAL_RS02780	COG0105	UTP biosynthetic process
THAL_RS02790	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
THAL_RS02795	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
THAL_RS02805	COG0698	ribose 5-phosphate isomerase
THAL_RS02810	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
THAL_RS02815	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
THAL_RS02835	COG0745	RESPONSE REGULATOR receiver
THAL_RS02850	COG0575	Belongs to the CDS family
THAL_RS02855	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
THAL_RS02870	COG0148	phosphopyruvate hydratase activity
THAL_RS02875	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
THAL_RS02880	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
THAL_RS02890	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
THAL_RS02895	COG0740	serine-type endopeptidase activity
THAL_RS02900	COG0544	peptidyl-prolyl cis-trans isomerase activity
THAL_RS02910	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
THAL_RS02915	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
THAL_RS02925	COG5000	phosphorelay sensor kinase activity
THAL_RS02945	COG1187	pseudouridine synthase activity
THAL_RS02950	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
THAL_RS02955	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
THAL_RS02960	COG0473	3-isopropylmalate dehydrogenase activity
THAL_RS02975	COG0537	adenosine 5'-monophosphoramidase activity
THAL_RS02980	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
THAL_RS02985	COG0583	DNA-binding transcription factor activity
THAL_RS02990	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
THAL_RS02995	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
THAL_RS02995	COG0301	tRNA thio-modification
THAL_RS03000	COG1331	Highly conserved protein containing a thioredoxin domain
THAL_RS03010	COG0552	protein localization to endoplasmic reticulum
THAL_RS03010	COG0457	Tetratricopeptide repeat
THAL_RS03015	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
THAL_RS03035	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
THAL_RS03045	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
THAL_RS03055	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
THAL_RS03060	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
THAL_RS03065	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
THAL_RS03075	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
THAL_RS03080	COG0089	rRNA binding
THAL_RS03085	COG0088	Forms part of the polypeptide exit tunnel
THAL_RS03090	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
THAL_RS03095	COG0051	transcription antitermination factor activity, RNA binding
THAL_RS03105	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
THAL_RS03110	COG0049	tRNA binding
THAL_RS03115	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
THAL_RS03125	COG0085	RNA polymerase activity
THAL_RS03130	COG0222	ribosome binding
THAL_RS03135	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
THAL_RS03140	COG0081	regulation of translation
THAL_RS03145	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
THAL_RS03150	COG0250	Participates in transcription elongation, termination and antitermination
THAL_RS03165	COG0267	Belongs to the bacterial ribosomal protein bL33 family
THAL_RS03195	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
THAL_RS03205	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
THAL_RS03210	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
THAL_RS03215	COG0307	riboflavin synthase, alpha
THAL_RS03220	COG0543	2 iron, 2 sulfur cluster binding
THAL_RS03225	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
THAL_RS03245	COG0196	riboflavin kinase activity
THAL_RS03255	COG0538	isocitrate dehydrogenase activity
THAL_RS03260	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
THAL_RS03265	COG1028	Short-chain dehydrogenase reductase Sdr
THAL_RS03270	COG0343	queuine tRNA-ribosyltransferase activity
THAL_RS03280	COG1815	bacterial-type flagellum-dependent cell motility
THAL_RS03285	COG1558	bacterial-type flagellum-dependent cell motility
THAL_RS03290	COG1677	Flagellar hook-basal body complex protein FliE
THAL_RS03295	COG1766	The M ring may be actively involved in energy transduction
THAL_RS03325	COG1144	Oxidoreductase
THAL_RS03335	COG1013	pyruvate-flavodoxin oxidoreductase activity
THAL_RS03340	COG0674	pyruvate-flavodoxin oxidoreductase activity
THAL_RS03350	COG0674	pyruvate-flavodoxin oxidoreductase activity
THAL_RS03350	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
THAL_RS03365	COG0495	leucyl-tRNA aminoacylation
THAL_RS03375	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
THAL_RS03390	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
THAL_RS03395	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
THAL_RS03400	COG0509	glycine decarboxylation via glycine cleavage system
THAL_RS03405	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
THAL_RS03410	COG0742	ribosomal rna small subunit methyltransferase
THAL_RS03415	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
THAL_RS03425	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
THAL_RS03445	COG0039	L-malate dehydrogenase activity
THAL_RS03450	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
THAL_RS03460	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
THAL_RS03465	COG1372	Participates in initiation and elongation during chromosome replication
THAL_RS03465	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
THAL_RS03470	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
THAL_RS03475	COG0542	response to heat
THAL_RS03480	COG1196	nuclear chromosome segregation
THAL_RS03490	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
THAL_RS03505	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
THAL_RS03515	COG0539	negative regulation of cytoplasmic translation
THAL_RS03540	COG1547	Domain of unknown function (DUF309)
THAL_RS03545	COG1078	dGTPase activity
THAL_RS03555	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
THAL_RS03560	COG1127	ABC transporter
THAL_RS03570	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
THAL_RS03575	COG0831	urea catabolic process
THAL_RS03585	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
THAL_RS03590	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
THAL_RS03595	COG0010	Belongs to the arginase family
THAL_RS03600	COG0831	urea catabolic process
THAL_RS03630	COG0832	Belongs to the urease beta subunit family
THAL_RS03630	COG0831	urea catabolic process
THAL_RS03635	COG0804	urea catabolic process
THAL_RS03645	COG0830	nickel cation binding
THAL_RS03655	COG0829	nickel cation binding
THAL_RS03670	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
THAL_RS03680	COG1921	L-seryl-tRNASec selenium transferase activity
THAL_RS03695	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
THAL_RS03695	COG3153	acetyltransferase
THAL_RS03700	COG0820	rRNA (adenine-C2-)-methyltransferase activity
THAL_RS03705	COG0681	Belongs to the peptidase S26 family
THAL_RS03730	COG0762	integral membrane protein
THAL_RS03735	COG0203	ribosomal protein L17
THAL_RS03740	COG0202	RNA polymerase activity
THAL_RS03745	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
THAL_RS03750	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
THAL_RS03755	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
THAL_RS03760	COG0257	Belongs to the bacterial ribosomal protein bL36 family
THAL_RS03765	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
THAL_RS03770	COG0024	Methionine aminopeptidase
THAL_RS03775	COG0563	adenylate kinase activity
THAL_RS03780	COG0201	protein transport
THAL_RS03785	COG0200	Binds to the 23S rRNA
THAL_RS03790	COG1841	ribosomal large subunit assembly
THAL_RS03795	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
THAL_RS03805	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
THAL_RS03810	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
THAL_RS03815	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
THAL_RS03820	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
THAL_RS03830	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
THAL_RS03835	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
THAL_RS03845	COG0737	Belongs to the 5'-nucleotidase family
THAL_RS03850	COG2010	Cytochrome c
THAL_RS03870	COG4232	protein-disulfide reductase activity
THAL_RS03885	COG0475	glutathione-regulated potassium exporter activity
THAL_RS03890	COG0756	dUTP diphosphatase activity
THAL_RS03910	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
THAL_RS03930	COG0824	Thioesterase
THAL_RS03940	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
THAL_RS03950	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
THAL_RS03955	COG3956	TIGRFAM MazG family protein
THAL_RS03960	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
THAL_RS03965	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
THAL_RS03970	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
THAL_RS03975	COG0820	rRNA (adenine-C2-)-methyltransferase activity
THAL_RS03980	COG1774	PSP1 C-terminal conserved region
THAL_RS03990	COG0439	Biotin carboxylase
THAL_RS04000	COG1013	pyruvate-flavodoxin oxidoreductase activity
THAL_RS04015	COG1144	Oxidoreductase
THAL_RS04020	COG0534	Mate efflux family protein
THAL_RS04050	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
THAL_RS04060	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
THAL_RS04065	COG1193	negative regulation of DNA recombination
THAL_RS04070	COG0446	pyridine nucleotide-disulphide oxidoreductase
THAL_RS04075	COG0217	transcriptional regulatory protein
THAL_RS04080	COG0251	oxidation-reduction process
THAL_RS04085	COG0305	Participates in initiation and elongation during chromosome replication
THAL_RS04090	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
THAL_RS04100	COG0107	imidazoleglycerol-phosphate synthase activity
THAL_RS04110	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
THAL_RS04115	COG1458	PINc domain ribonuclease
THAL_RS04125	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
THAL_RS04140	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
THAL_RS04140	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
THAL_RS04145	COG0297	glycogen (starch) synthase activity
THAL_RS04170	COG0149	triose-phosphate isomerase activity
THAL_RS04190	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
THAL_RS04195	COG0019	diaminopimelate decarboxylase activity
THAL_RS04200	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
THAL_RS04210	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
THAL_RS04215	COG0805	protein transport
THAL_RS04225	COG0163	prenyltransferase activity
THAL_RS04235	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
THAL_RS04245	COG3302	dmso reductase anchor subunit
THAL_RS04250	COG0437	4 iron, 4 sulfur cluster binding
THAL_RS04255	COG0243	molybdopterin cofactor binding
THAL_RS04265	COG0303	'Molybdopterin
THAL_RS04270	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
THAL_RS04275	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
THAL_RS04280	COG0037	tRNA processing
THAL_RS04290	COG0633	Ferredoxin
THAL_RS04300	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
THAL_RS04310	COG0505	Belongs to the CarA family
THAL_RS04320	COG0557	exoribonuclease II activity
THAL_RS04325	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
THAL_RS04370	COG2270	Major facilitator Superfamily
THAL_RS04375	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
THAL_RS04395	COG0644	oxidoreductase
THAL_RS04405	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
THAL_RS04415	COG4752	Belongs to the RNA methyltransferase TrmD family
THAL_RS04420	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
THAL_RS04425	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
THAL_RS04435	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
THAL_RS04455	COG0811	peptide transport
THAL_RS04465	COG0406	alpha-ribazole phosphatase activity
THAL_RS04470	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
THAL_RS04480	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
THAL_RS04495	COG1309	transcriptional regulator
THAL_RS04500	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
THAL_RS04500	COG0512	Glutamine amidotransferase of anthranilate synthase
THAL_RS04505	COG1324	tolerance protein
THAL_RS04515	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
THAL_RS04520	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
THAL_RS04525	COG0083	homoserine kinase activity
THAL_RS04530	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
THAL_RS04535	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
THAL_RS04540	COG1137	ATPase activity
THAL_RS04545	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
THAL_RS04555	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
THAL_RS04565	COG0333	Belongs to the bacterial ribosomal protein bL32 family
THAL_RS04570	COG0416	fatty acid biosynthetic process
THAL_RS04575	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
THAL_RS04580	COG1515	deoxyribonuclease V activity
THAL_RS04635	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
THAL_RS04650	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
THAL_RS04655	COG0517	IMP dehydrogenase activity
THAL_RS04655	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
THAL_RS04655	COG0617	tRNA 3'-terminal CCA addition
THAL_RS04660	COG2890	protein-(glutamine-N5) methyltransferase activity
THAL_RS04665	COG1253	flavin adenine dinucleotide binding
THAL_RS04675	COG2222	sugar isomerase
THAL_RS04685	COG0606	chelatase, subunit chli
THAL_RS04690	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
THAL_RS04695	COG1276	copper resistance
THAL_RS04700	COG0357	Ribosomal RNA small subunit methyltransferase G
THAL_RS04705	COG1999	signal sequence binding
THAL_RS04710	COG0481	GTPase activity
THAL_RS04715	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
THAL_RS04720	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
THAL_RS04735	COG1605	Chorismate mutase
THAL_RS04735	COG0077	Prephenate dehydratase
THAL_RS04745	COG0330	HflC and HflK could
THAL_RS04755	COG0180	Tryptophanyl-tRNA synthetase
THAL_RS04760	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
THAL_RS04770	COG0802	atpase or kinase
THAL_RS04775	COG0439	Biotin carboxylase
THAL_RS04790	COG1592	Rubrerythrin
THAL_RS04795	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
THAL_RS04800	COG0509	glycine decarboxylation via glycine cleavage system
THAL_RS04815	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
THAL_RS04820	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
THAL_RS04825	COG1573	uracil-dna glycosylase
THAL_RS04830	COG0003	Pfam Anion-transporting ATPase
THAL_RS04845	COG0730	response to heat
THAL_RS04855	COG0440	acetolactate synthase activity
THAL_RS04860	COG0352	thiamine-phosphate diphosphorylase activity
THAL_RS04865	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
THAL_RS04870	COG4786	Flagellar basal body rod
THAL_RS04880	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
THAL_RS04885	COG0243	molybdopterin cofactor binding
THAL_RS04885	COG3383	formate dehydrogenase (NAD+) activity
THAL_RS04890	COG3383	formate dehydrogenase (NAD+) activity
THAL_RS04890	COG0243	molybdopterin cofactor binding
THAL_RS04895	COG0437	4 iron, 4 sulfur cluster binding
THAL_RS04900	COG2864	formate dehydrogenase
THAL_RS04905	COG2032	superoxide dismutase activity
THAL_RS04910	COG3058	Necessary for formate dehydrogenase activity
THAL_RS04915	COG0509	glycine decarboxylation via glycine cleavage system
THAL_RS04920	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
THAL_RS04950	COG2199	diguanylate cyclase activity
THAL_RS04950	COG2200	EAL domain
THAL_RS04950	COG2202	Pas domain
THAL_RS04955	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
THAL_RS04960	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
THAL_RS04965	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
THAL_RS04980	COG0425	Belongs to the sulfur carrier protein TusA family
THAL_RS04985	COG0482	sulfurtransferase activity
THAL_RS04990	COG0822	iron-sulfur transferase activity
THAL_RS04995	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
THAL_RS05005	COG0601	transmembrane transport
THAL_RS05010	COG0693	protein deglycase activity
THAL_RS05015	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
THAL_RS05020	COG1968	undecaprenyl-diphosphatase activity
THAL_RS05025	COG0070	glutamate synthase
THAL_RS05025	COG0069	glutamate synthase activity
THAL_RS05025	COG0067	glutamate synthase
THAL_RS05030	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
THAL_RS05030	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
THAL_RS05040	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
THAL_RS05045	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
THAL_RS05050	COG0750	zinc metalloprotease
THAL_RS05055	COG0432	Pfam Uncharacterised protein family UPF0047
THAL_RS05065	COG2151	metal-sulfur cluster biosynthetic enzyme
THAL_RS05075	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
THAL_RS05085	COG0006	proline dipeptidase activity
THAL_RS05095	COG1253	flavin adenine dinucleotide binding
THAL_RS05100	COG4608	Belongs to the ABC transporter superfamily
THAL_RS05105	COG0635	Involved in the biosynthesis of porphyrin-containing compound
THAL_RS05110	COG0714	Associated with various cellular activities
THAL_RS05115	COG0113	porphobilinogen synthase activity
THAL_RS05120	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
THAL_RS05130	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
THAL_RS05140	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
THAL_RS05145	COG0151	Belongs to the GarS family
THAL_RS05150	COG0628	permease
THAL_RS05155	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
THAL_RS05160	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
THAL_RS05170	COG1333	cytochrome c biogenesis protein
THAL_RS05180	COG0242	peptide deformylase activity
THAL_RS05185	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
THAL_RS05205	COG1012	belongs to the aldehyde dehydrogenase family
THAL_RS05210	COG0785	Cytochrome C biogenesis protein
THAL_RS05215	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
THAL_RS05220	COG0284	orotidine-5'-phosphate decarboxylase activity
THAL_RS05225	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
THAL_RS05230	COG0709	Synthesizes selenophosphate from selenide and ATP
THAL_RS05240	COG1966	Carbon starvation protein
THAL_RS05245	COG1530	ribonuclease E activity
THAL_RS05250	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
THAL_RS05255	COG0799	negative regulation of ribosome biogenesis
THAL_RS05265	COG1100	Small GTP-binding protein
THAL_RS05275	COG0442	prolyl-tRNA aminoacylation
THAL_RS05280	COG0758	DNA mediated transformation
THAL_RS05290	COG0525	valine-tRNA ligase activity
THAL_RS05310	COG0375	protein maturation
THAL_RS05315	COG0298	carbon dioxide binding
THAL_RS05320	COG0409	Hydrogenase expression formation protein
THAL_RS05325	COG1024	Enoyl-CoA hydratase
THAL_RS05325	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
THAL_RS05335	COG1122	ATPase activity
THAL_RS05345	COG0310	cobalt ion transport
THAL_RS05370	COG1902	pentaerythritol trinitrate reductase activity
THAL_RS05375	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
THAL_RS05390	COG0425	Belongs to the sulfur carrier protein TusA family
THAL_RS05395	COG0134	indole-3-glycerol-phosphate synthase activity
THAL_RS05405	COG0126	phosphoglycerate kinase activity
THAL_RS05410	COG0483	inositol monophosphate 1-phosphatase activity
THAL_RS05415	COG0589	response to stress
THAL_RS05450	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
THAL_RS05455	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
THAL_RS05465	COG1067	ATP-dependent peptidase activity
THAL_RS05470	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
THAL_RS05475	COG4654	Cytochrome c, class I
THAL_RS05480	COG0493	'glutamate synthase
THAL_RS05480	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
THAL_RS05490	COG0772	Belongs to the SEDS family
THAL_RS05495	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
THAL_RS05520	COG0793	Belongs to the peptidase S41A family
THAL_RS05525	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
THAL_RS05530	COG1108	ABC-type Mn2 Zn2 transport systems permease components
THAL_RS05540	COG3746	phosphate-selective porin O and P
THAL_RS05550	COG0705	Rhomboid family
THAL_RS05555	COG0604	alcohol dehydrogenase
THAL_RS05575	COG3634	alkyl hydroperoxide reductase activity
THAL_RS05595	COG0443	Heat shock 70 kDa protein
THAL_RS05605	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
THAL_RS05625	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
THAL_RS05630	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
THAL_RS05645	COG2204	response regulator
THAL_RS05660	COG0730	response to heat
THAL_RS05665	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
THAL_RS05665	COG1648	precorrin-2 dehydrogenase activity
THAL_RS05670	COG2046	Belongs to the sulfate adenylyltransferase family
THAL_RS05675	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
THAL_RS05680	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
THAL_RS05690	COG1811	Na channel or pump
THAL_RS05695	COG4641	Protein conserved in bacteria
THAL_RS05700	COG0287	Prephenate dehydrogenase
THAL_RS05705	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
THAL_RS05715	COG1242	4 iron, 4 sulfur cluster binding
THAL_RS05735	COG1580	Controls the rotational direction of flagella during chemotaxis
THAL_RS05745	COG1338	Plays a role in the flagellum-specific transport system
THAL_RS05750	COG1987	bacterial-type flagellum assembly
THAL_RS05755	COG1684	flagellar biosynthetic protein fliR
THAL_RS05760	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
THAL_RS05775	COG2154	pterin-4-alpha-carbinolamine dehydratase
THAL_RS05785	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
THAL_RS05810	COG1100	Small GTP-binding protein
THAL_RS05850	COG1191	sigma factor activity
THAL_RS05865	COG1730	sister chromatid segregation
THAL_RS05870	COG2010	Cytochrome c
THAL_RS05885	COG0358	DNA primase activity
THAL_RS05890	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
THAL_RS05920	COG4942	peptidase
THAL_RS05935	COG0355	proton-transporting ATP synthase activity, rotational mechanism
THAL_RS05940	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
THAL_RS05950	COG1419	protein localization to endoplasmic reticulum
THAL_RS05955	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
THAL_RS05960	COG0779	Required for maturation of 30S ribosomal subunits
THAL_RS05970	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
THAL_RS05980	COG4591	ABC-type transport system involved in lipoprotein release permease component
THAL_RS05985	COG0577	efflux transmembrane transporter activity
THAL_RS05985	COG1136	(ABC) transporter
THAL_RS05990	COG0157	Belongs to the NadC ModD family
THAL_RS05995	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
THAL_RS06000	COG0726	polysaccharide deacetylase
THAL_RS06010	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
THAL_RS06015	COG2894	cell division
THAL_RS06020	COG0850	regulation of cytokinetic process
THAL_RS06030	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
THAL_RS06035	COG0706	membrane insertase activity
THAL_RS06040	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
THAL_RS06050	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
THAL_RS06055	COG0356	it plays a direct role in the translocation of protons across the membrane
THAL_RS06060	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
THAL_RS06060	COG0316	Belongs to the HesB IscA family
THAL_RS06065	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
THAL_RS06080	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
THAL_RS06090	COG0354	folic acid binding
THAL_RS06095	COG2067	long-chain fatty acid transport protein
THAL_RS06105	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
THAL_RS06115	COG2132	Multicopper oxidase
THAL_RS06125	COG1059	Responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine 7-oxoG) from DNA. Also nicks DNA at apurinic apyrimidinic sites (AP sites)
THAL_RS06130	COG0497	DNA recombination
THAL_RS06135	COG0516	GMP reductase activity
THAL_RS06135	COG0517	IMP dehydrogenase activity
THAL_RS06140	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
THAL_RS06145	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
THAL_RS06150	COG0839	Belongs to the complex I subunit 6 family
THAL_RS06155	COG0713	ATP synthesis coupled electron transport
THAL_RS06170	COG1007	ATP synthesis coupled electron transport
THAL_RS06175	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
THAL_RS06180	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
THAL_RS06180	COG0649	NAD binding
THAL_RS06185	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
THAL_RS06190	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
THAL_RS06200	COG0713	ATP synthesis coupled electron transport
THAL_RS06215	COG1007	ATP synthesis coupled electron transport
THAL_RS06220	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
THAL_RS06225	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
THAL_RS06230	COG0592	DNA-directed DNA polymerase activity
THAL_RS06235	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
THAL_RS06240	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
THAL_RS06245	COG1525	nuclease
THAL_RS06250	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
THAL_RS06255	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
THAL_RS06260	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
THAL_RS06265	COG0058	SHG alpha-glucan phosphorylase activity
THAL_RS06275	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
THAL_RS06280	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
THAL_RS06290	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
THAL_RS06295	COG0583	DNA-binding transcription factor activity
THAL_RS06300	COG0463	Glycosyl transferase, family 2
THAL_RS06310	COG1355	regulation of microtubule-based process
THAL_RS06315	COG0477	Major facilitator Superfamily
THAL_RS06325	COG1640	4-alpha-glucanotransferase
THAL_RS06330	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
THAL_RS06335	COG1706	bacterial-type flagellum-dependent cell motility
THAL_RS06340	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
THAL_RS06345	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
THAL_RS06350	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
THAL_RS06355	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
THAL_RS06370	COG1994	Peptidase M50
THAL_RS06375	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
THAL_RS06380	COG0402	S-adenosylhomocysteine deaminase activity
THAL_RS06405	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
THAL_RS06410	COG1459	type II secretion system
THAL_RS06420	COG0859	PFAM glycosyl transferase family 9
THAL_RS06430	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
THAL_RS06435	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
THAL_RS06440	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
THAL_RS06445	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
THAL_RS06450	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
THAL_RS06455	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
THAL_RS06465	COG0542	response to heat
THAL_RS06470	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
THAL_RS06475	COG0702	epimerase
THAL_RS06510	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
THAL_RS06525	COG2022	thiamine diphosphate biosynthetic process
THAL_RS06530	COG2104	thiamine diphosphate biosynthetic process
THAL_RS06535	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
THAL_RS06540	COG2189	Belongs to the N(4) N(6)-methyltransferase family
THAL_RS06550	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
THAL_RS06560	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
THAL_RS06565	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
THAL_RS06575	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
THAL_RS06580	COG1993	acr, cog1993
THAL_RS06585	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
THAL_RS06590	COG1993	acr, cog1993
THAL_RS06605	COG2205	protein histidine kinase activity
THAL_RS06635	COG0745	RESPONSE REGULATOR receiver
THAL_RS06640	COG0511	ligase activity, forming carbon-carbon bonds
THAL_RS06640	COG5016	pyruvate
THAL_RS06645	COG0815	Transfers the fatty acyl group on membrane lipoproteins
THAL_RS06660	COG0776	regulation of translation
THAL_RS06665	COG1385	rRNA (uridine-N3-)-methyltransferase activity
THAL_RS06670	COG0347	Belongs to the P(II) protein family
THAL_RS06675	COG0174	glutamine synthetase
THAL_RS06680	COG0004	ammonium transporteR
THAL_RS06690	COG1011	Hydrolase
THAL_RS06695	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
THAL_RS06695	COG1648	precorrin-2 dehydrogenase activity
THAL_RS06705	COG0243	molybdopterin cofactor binding
THAL_RS06710	COG1116	anion transmembrane transporter activity
THAL_RS06715	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
THAL_RS06720	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
THAL_RS06725	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
THAL_RS06745	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
THAL_RS06750	COG0519	Catalyzes the synthesis of GMP from XMP
THAL_RS06750	COG0518	GMP synthase (glutamine-hydrolyzing) activity
THAL_RS06760	COG0003	Pfam Anion-transporting ATPase
THAL_RS06770	COG4654	Cytochrome c, class I
THAL_RS06775	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
THAL_RS06785	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
THAL_RS06790	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
THAL_RS06810	COG0509	glycine decarboxylation via glycine cleavage system
THAL_RS06825	COG0509	glycine decarboxylation via glycine cleavage system
THAL_RS06845	COG3634	alkyl hydroperoxide reductase activity
THAL_RS06865	COG2210	Belongs to the sulfur carrier protein TusA family
THAL_RS06870	COG0425	Belongs to the sulfur carrier protein TusA family
THAL_RS06875	COG0123	including yeast histone deacetylase and acetoin utilization protein
THAL_RS06885	COG0828	Belongs to the bacterial ribosomal protein bS21 family
THAL_RS06890	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
THAL_RS06895	COG0492	ferredoxin-NADP+ reductase activity
THAL_RS06900	COG3118	belongs to the thioredoxin family
THAL_RS06910	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
THAL_RS06920	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
THAL_RS06930	COG1335	isochorismatase
THAL_RS06945	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
THAL_RS06960	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
THAL_RS06960	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
THAL_RS06980	COG1077	Cell shape determining protein MreB Mrl
THAL_RS06985	COG3411	Ferredoxin
THAL_RS06990	COG1923	regulation of RNA biosynthetic process
THAL_RS07000	COG0501	Belongs to the peptidase M48B family
THAL_RS07005	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
THAL_RS07010	COG2226	methyltransferase
THAL_RS07015	COG0556	nucleotide-excision repair
THAL_RS07020	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
THAL_RS07025	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
THAL_RS07035	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
THAL_RS07045	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
THAL_RS07050	COG0129	dihydroxy-acid dehydratase activity
THAL_RS07060	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
THAL_RS07110	COG0187	DNA topoisomerase II activity
THAL_RS07120	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
THAL_RS07130	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
THAL_RS07190	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
THAL_RS07195	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
THAL_RS07200	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
THAL_RS07220	COG0651	ATP synthesis coupled electron transport
THAL_RS07235	COG0651	ATP synthesis coupled electron transport
THAL_RS07240	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
THAL_RS07240	COG0649	NAD binding
THAL_RS07240	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
THAL_RS07245	COG3260	NADH ubiquinone oxidoreductase 20
THAL_RS07255	COG2871	sodium ion transport
THAL_RS07260	COG0726	polysaccharide deacetylase
THAL_RS07265	COG2815	serine threonine protein kinase
THAL_RS07265	COG0515	serine threonine protein kinase
THAL_RS07295	COG0438	transferase activity, transferring glycosyl groups
THAL_RS07295	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
THAL_RS07305	COG0142	geranyltranstransferase activity
THAL_RS07320	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
THAL_RS07325	COG1334	flagellar protein FlaG
THAL_RS07340	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
THAL_RS07345	COG0459	protein refolding
THAL_RS07350	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
THAL_RS07355	COG0492	ferredoxin-NADP+ reductase activity
THAL_RS07365	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
THAL_RS07370	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
THAL_RS07380	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
THAL_RS07385	COG0616	signal peptide processing
THAL_RS07415	COG1278	Cold shock
THAL_RS07420	COG0045	succinate-CoA ligase (ADP-forming) activity
THAL_RS07430	COG1088	dTDP-glucose 4,6-dehydratase activity
THAL_RS07450	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
THAL_RS07455	COG0540	Belongs to the ATCase OTCase family
THAL_RS07460	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
THAL_RS07465	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
THAL_RS07470	COG1260	myo-inositol-1-phosphate synthase
THAL_RS07475	COG1519	Transferase
THAL_RS07485	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
THAL_RS07495	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
THAL_RS07500	COG0066	3-isopropylmalate dehydratase activity
THAL_RS07515	COG1612	heme a metabolic process
THAL_RS07520	COG0109	protoheme IX farnesyltransferase activity
THAL_RS07525	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
THAL_RS07530	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
THAL_RS07535	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
THAL_RS07540	COG0052	Belongs to the universal ribosomal protein uS2 family
THAL_RS07545	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
THAL_RS07550	COG0528	UMP kinase activity
THAL_RS07555	COG0233	cytoplasmic translational termination
THAL_RS07575	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
THAL_RS07595	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
THAL_RS07600	COG0482	sulfurtransferase activity
THAL_RS07620	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
THAL_RS07625	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
THAL_RS07630	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
THAL_RS07635	COG1490	D-aminoacyl-tRNA deacylase activity
THAL_RS07645	COG1845	cytochrome c oxidase, subunit III
THAL_RS07655	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
THAL_RS07660	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
THAL_RS07660	COG1845	cytochrome c oxidase, subunit III
THAL_RS07670	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
THAL_RS07670	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
THAL_RS07675	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
THAL_RS07680	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
THAL_RS07685	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
THAL_RS07695	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
THAL_RS07700	COG0140	phosphoribosyl-ATP diphosphatase activity
THAL_RS07700	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
THAL_RS07710	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
THAL_RS07715	COG0543	2 iron, 2 sulfur cluster binding
THAL_RS07720	COG0436	Aminotransferase
THAL_RS07735	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
THAL_RS07745	COG1980	fructose-bisphosphate aldolase activity
THAL_RS07750	COG0864	Transcriptional regulator
THAL_RS07755	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
THAL_RS07765	COG2226	methyltransferase
THAL_RS07770	COG0211	Belongs to the bacterial ribosomal protein bL27 family
THAL_RS07775	COG0261	This protein binds to 23S rRNA in the presence of protein L20
THAL_RS07790	COG0159	tryptophan synthase activity
THAL_RS07800	COG0511	ligase activity, forming carbon-carbon bonds
THAL_RS07805	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
THAL_RS07810	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
THAL_RS07820	COG1424	Catalyzes the transformation of pimelate into pimeloyl- CoA with concomitant hydrolysis of ATP to AMP
THAL_RS07835	COG1561	YicC-like family, N-terminal region
THAL_RS07845	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
THAL_RS07850	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
THAL_RS07855	COG0433	COG0433 Predicted ATPase
THAL_RS07860	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
THAL_RS07870	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
THAL_RS07890	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
THAL_RS07895	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
THAL_RS07900	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
THAL_RS07910	COG0156	8-amino-7-oxononanoate synthase activity
THAL_RS07915	COG1648	precorrin-2 dehydrogenase activity
THAL_RS07915	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
THAL_RS07935	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
THAL_RS07940	COG1832	CoA-binding protein
THAL_RS07945	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
THAL_RS07950	COG2877	3-deoxy-8-phosphooctulonate synthase activity
THAL_RS07955	COG0752	glycyl-tRNA synthetase alpha subunit
THAL_RS07960	COG1845	cytochrome c oxidase, subunit III
THAL_RS07970	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
THAL_RS07975	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
THAL_RS07975	COG1845	cytochrome c oxidase, subunit III
THAL_RS07995	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
THAL_RS08000	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
THAL_RS08015	COG0363	glucosamine-6-phosphate deaminase activity
THAL_RS08020	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
THAL_RS08025	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
THAL_RS08035	COG0138	bifunctional purine biosynthesis protein purh
THAL_RS08040	COG0047	phosphoribosylformylglycinamidine synthase activity
THAL_RS08050	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
THAL_RS08070	COG1796	DNA polymerase
THAL_RS08070	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
THAL_RS08080	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
THAL_RS08120	COG0336	Belongs to the RNA methyltransferase TrmD family
THAL_RS08130	COG0012	GTP binding
THAL_RS08165	COG5001	Diguanylate cyclase
THAL_RS08165	COG5002	protein histidine kinase activity
THAL_RS08170	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
THAL_RS08175	COG0484	heat shock protein binding
THAL_RS08180	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
THAL_RS08195	COG3439	Domain of unknown function DUF302
THAL_RS08200	COG3706	GGDEF domain