locus-tag	class	description
THERU_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
THERU_RS00010	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
THERU_RS00015	COG0805	protein transport
THERU_RS00020	COG0287	Prephenate dehydrogenase
THERU_RS00025	COG0123	including yeast histone deacetylase and acetoin utilization protein
THERU_RS00030	COG1372	Participates in initiation and elongation during chromosome replication
THERU_RS00030	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
THERU_RS00035	COG1324	tolerance protein
THERU_RS00040	COG0512	Glutamine amidotransferase of anthranilate synthase
THERU_RS00040	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
THERU_RS00045	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
THERU_RS00050	COG1489	DNA binding
THERU_RS00055	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
THERU_RS00075	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
THERU_RS00085	COG0445	tRNA wobble uridine modification
THERU_RS00100	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
THERU_RS00105	COG1959	2 iron, 2 sulfur cluster binding
THERU_RS00120	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
THERU_RS00125	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
THERU_RS00130	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
THERU_RS00150	COG0425	Belongs to the sulfur carrier protein TusA family
THERU_RS00155	COG2210	Belongs to the sulfur carrier protein TusA family
THERU_RS00175	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
THERU_RS00195	COG0509	glycine decarboxylation via glycine cleavage system
THERU_RS00210	COG0509	glycine decarboxylation via glycine cleavage system
THERU_RS00230	COG1611	Belongs to the LOG family
THERU_RS00240	COG0419	ATPase involved in DNA repair
THERU_RS00250	COG2222	sugar isomerase
THERU_RS00260	COG4535	Mg2 and Co2 transporter CorC
THERU_RS00265	COG2890	protein-(glutamine-N5) methyltransferase activity
THERU_RS00270	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
THERU_RS00285	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
THERU_RS00290	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
THERU_RS00295	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
THERU_RS00300	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
THERU_RS00310	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
THERU_RS00315	COG0720	synthase
THERU_RS00320	COG0828	Belongs to the bacterial ribosomal protein bS21 family
THERU_RS00325	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
THERU_RS00335	COG3118	belongs to the thioredoxin family
THERU_RS00355	COG0475	glutathione-regulated potassium exporter activity
THERU_RS00360	COG0490	domain, Protein
THERU_RS00365	COG0789	Transcriptional regulator
THERU_RS00370	COG0484	heat shock protein binding
THERU_RS00375	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
THERU_RS00380	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
THERU_RS00410	COG1530	ribonuclease E activity
THERU_RS00415	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
THERU_RS00420	COG0799	negative regulation of ribosome biogenesis
THERU_RS00440	COG1385	rRNA (uridine-N3-)-methyltransferase activity
THERU_RS00445	COG0776	regulation of translation
THERU_RS00460	COG2814	Major facilitator Superfamily
THERU_RS00465	COG1566	PFAM secretion protein HlyD family protein
THERU_RS00490	COG0546	phosphoglycolate phosphatase activity
THERU_RS00495	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
THERU_RS00500	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
THERU_RS00505	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
THERU_RS00520	COG1812	S-adenosylmethionine synthetase (AdoMet synthetase)
THERU_RS00530	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
THERU_RS00540	COG0003	Pfam Anion-transporting ATPase
THERU_RS00545	COG1573	uracil-dna glycosylase
THERU_RS00550	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
THERU_RS00560	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
THERU_RS00565	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
THERU_RS00570	COG0432	Pfam Uncharacterised protein family UPF0047
THERU_RS00580	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
THERU_RS00585	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
THERU_RS00590	COG0204	Acyl-transferase
THERU_RS00595	COG1515	deoxyribonuclease V activity
THERU_RS00600	COG0587	DNA-directed DNA polymerase activity
THERU_RS00605	COG0631	protein serine/threonine phosphatase activity
THERU_RS00610	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
THERU_RS00635	COG0793	Belongs to the peptidase S41A family
THERU_RS00640	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
THERU_RS00645	COG0312	modulator of DNA gyrase
THERU_RS00650	COG0330	HflC and HflK could
THERU_RS00660	COG1605	Chorismate mutase
THERU_RS00660	COG0077	Prephenate dehydratase
THERU_RS00670	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
THERU_RS00680	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
THERU_RS00690	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
THERU_RS00695	COG1012	belongs to the aldehyde dehydrogenase family
THERU_RS00700	COG0785	Cytochrome C biogenesis protein
THERU_RS00705	COG0473	3-isopropylmalate dehydrogenase activity
THERU_RS00720	COG1516	flagellar protein fliS
THERU_RS00725	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
THERU_RS00730	COG1334	flagellar protein FlaG
THERU_RS00740	COG3411	Ferredoxin
THERU_RS00745	COG1923	regulation of RNA biosynthetic process
THERU_RS00755	COG0501	Belongs to the peptidase M48B family
THERU_RS00760	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
THERU_RS00765	COG0628	permease
THERU_RS00775	COG0357	Ribosomal RNA small subunit methyltransferase G
THERU_RS00780	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
THERU_RS00785	COG2003	Belongs to the UPF0758 family
THERU_RS00795	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
THERU_RS00810	COG1845	cytochrome c oxidase, subunit III
THERU_RS00810	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
THERU_RS00815	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
THERU_RS00825	COG1845	cytochrome c oxidase, subunit III
THERU_RS00830	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
THERU_RS00835	COG0575	Belongs to the CDS family
THERU_RS00840	COG4796	Type ii and iii secretion system protein
THERU_RS00865	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
THERU_RS00870	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
THERU_RS00875	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
THERU_RS00885	COG0356	it plays a direct role in the translocation of protons across the membrane
THERU_RS00890	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
THERU_RS00900	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
THERU_RS00905	COG0706	membrane insertase activity
THERU_RS00910	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
THERU_RS00915	COG5002	protein histidine kinase activity
THERU_RS00920	COG2018	Roadblock/LC7 domain
THERU_RS00925	COG1100	Small GTP-binding protein
THERU_RS00940	COG0704	Plays a role in the regulation of phosphate uptake
THERU_RS00945	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
THERU_RS00950	COG0297	glycogen (starch) synthase activity
THERU_RS00955	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
THERU_RS00955	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
THERU_RS00960	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
THERU_RS00965	COG1994	Peptidase M50
THERU_RS00985	COG0157	Belongs to the NadC ModD family
THERU_RS00990	COG0058	SHG alpha-glucan phosphorylase activity
THERU_RS01000	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
THERU_RS01005	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
THERU_RS01015	COG0180	Tryptophanyl-tRNA synthetase
THERU_RS01030	COG0750	zinc metalloprotease
THERU_RS01050	COG0406	alpha-ribazole phosphatase activity
THERU_RS01055	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
THERU_RS01060	COG2022	thiamine diphosphate biosynthetic process
THERU_RS01060	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
THERU_RS01065	COG0513	Belongs to the DEAD box helicase family
THERU_RS01075	COG1067	ATP-dependent peptidase activity
THERU_RS01080	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
THERU_RS01095	COG0154	amidase activity
THERU_RS01110	COG0860	N-Acetylmuramoyl-L-alanine amidase
THERU_RS01115	COG0602	queuosine metabolic process
THERU_RS01120	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
THERU_RS01130	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
THERU_RS01145	COG1758	RNA polymerase activity
THERU_RS01150	COG0194	GDP metabolic process
THERU_RS01180	COG1077	Cell shape determining protein MreB Mrl
THERU_RS01185	COG0442	prolyl-tRNA aminoacylation
THERU_RS01190	COG0758	DNA mediated transformation
THERU_RS01195	COG0658	competence protein
THERU_RS01200	COG0133	tryptophan synthase activity
THERU_RS01205	COG2189	Belongs to the N(4) N(6)-methyltransferase family
THERU_RS01215	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
THERU_RS01220	COG0750	zinc metalloprotease
THERU_RS01225	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
THERU_RS01230	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
THERU_RS01245	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
THERU_RS01275	COG1404	Belongs to the peptidase S8 family
THERU_RS01280	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
THERU_RS01285	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
THERU_RS01290	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
THERU_RS01300	COG0095	Lipoate-protein ligase
THERU_RS01305	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
THERU_RS01315	COG1078	dGTPase activity
THERU_RS01320	COG1547	Domain of unknown function (DUF309)
THERU_RS01325	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
THERU_RS01335	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
THERU_RS01340	COG0475	glutathione-regulated potassium exporter activity
THERU_RS01345	COG0756	dUTP diphosphatase activity
THERU_RS01365	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
THERU_RS01370	COG0516	GMP reductase activity
THERU_RS01370	COG0517	IMP dehydrogenase activity
THERU_RS01375	COG1028	Short-chain dehydrogenase reductase Sdr
THERU_RS01385	COG4478	integral membrane protein
THERU_RS01400	COG2105	PFAM AIG2 family protein
THERU_RS01420	COG0443	Heat shock 70 kDa protein
THERU_RS01425	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
THERU_RS01430	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
THERU_RS01440	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
THERU_RS01445	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
THERU_RS01450	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
THERU_RS01455	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
THERU_RS01465	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
THERU_RS01470	COG1841	ribosomal large subunit assembly
THERU_RS01475	COG0200	Binds to the 23S rRNA
THERU_RS01480	COG0201	protein transport
THERU_RS01485	COG0563	adenylate kinase activity
THERU_RS01490	COG0024	Methionine aminopeptidase
THERU_RS01495	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
THERU_RS01500	COG0257	Belongs to the bacterial ribosomal protein bL36 family
THERU_RS01505	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
THERU_RS01510	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
THERU_RS01515	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
THERU_RS01520	COG0202	RNA polymerase activity
THERU_RS01525	COG0203	ribosomal protein L17
THERU_RS01530	COG0762	integral membrane protein
THERU_RS01535	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
THERU_RS01555	COG0681	Belongs to the peptidase S26 family
THERU_RS01560	COG0820	rRNA (adenine-C2-)-methyltransferase activity
THERU_RS01570	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
THERU_RS01575	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
THERU_RS01590	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
THERU_RS01600	COG0438	transferase activity, transferring glycosyl groups
THERU_RS01615	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
THERU_RS01620	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
THERU_RS01635	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
THERU_RS01645	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
THERU_RS01650	COG0391	Required for morphogenesis under gluconeogenic growth conditions
THERU_RS01665	COG0355	proton-transporting ATP synthase activity, rotational mechanism
THERU_RS01680	COG4942	peptidase
THERU_RS01695	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
THERU_RS01710	COG0196	riboflavin kinase activity
THERU_RS01735	COG0612	Peptidase, M16
THERU_RS01745	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
THERU_RS01750	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
THERU_RS01755	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
THERU_RS01760	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
THERU_RS01765	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
THERU_RS01775	COG0124	histidyl-tRNA synthetase
THERU_RS01785	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
THERU_RS01790	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
THERU_RS01795	COG2204	response regulator
THERU_RS01800	COG0138	bifunctional purine biosynthesis protein purh
THERU_RS01805	COG0047	phosphoribosylformylglycinamidine synthase activity
THERU_RS01810	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
THERU_RS01820	COG1968	undecaprenyl-diphosphatase activity
THERU_RS01845	COG0305	Participates in initiation and elongation during chromosome replication
THERU_RS01855	COG0129	dihydroxy-acid dehydratase activity
THERU_RS01860	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
THERU_RS01870	COG1862	Preprotein translocase
THERU_RS01875	COG0318	PFAM AMP-dependent synthetase and ligase
THERU_RS01880	COG0528	UMP kinase activity
THERU_RS01885	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
THERU_RS01890	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
THERU_RS01925	COG3275	phosphorelay sensor kinase activity
THERU_RS01955	COG2217	Heavy metal translocating P-type atpase
THERU_RS01990	COG0811	peptide transport
THERU_RS01995	COG0848	biopolymer transport protein
THERU_RS02015	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
THERU_RS02020	COG4786	Flagellar basal body rod
THERU_RS02025	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
THERU_RS02030	COG0352	thiamine-phosphate diphosphorylase activity
THERU_RS02035	COG1832	CoA-binding protein
THERU_RS02040	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
THERU_RS02045	COG0509	glycine decarboxylation via glycine cleavage system
THERU_RS02055	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
THERU_RS02060	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
THERU_RS02070	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
THERU_RS02075	COG0569	domain protein
THERU_RS02080	COG1663	tetraacyldisaccharide 4'-kinase activity
THERU_RS02090	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
THERU_RS02095	COG0083	homoserine kinase activity
THERU_RS02105	COG2346	COG2346, Truncated hemoglobins
THERU_RS02120	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
THERU_RS02125	COG2911	Protein conserved in bacteria
THERU_RS02140	COG0776	regulation of translation
THERU_RS02145	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
THERU_RS02145	COG0539	negative regulation of cytoplasmic translation
THERU_RS02160	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
THERU_RS02170	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
THERU_RS02180	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
THERU_RS02190	COG0463	Glycosyl transferase, family 2
THERU_RS02200	COG0436	Aminotransferase
THERU_RS02205	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
THERU_RS02220	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
THERU_RS02225	COG1618	nucleotide phosphatase activity, acting on free nucleotides
THERU_RS02235	COG0436	Aminotransferase
THERU_RS02250	COG1335	isochorismatase
THERU_RS02255	COG1216	Glycosyl transferase, family 2
THERU_RS02260	COG1465	3-dehydroquinate synthase
THERU_RS02265	COG0181	hydroxymethylbilane synthase activity
THERU_RS02270	COG1993	acr, cog1993
THERU_RS02275	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
THERU_RS02280	COG1993	acr, cog1993
THERU_RS02290	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
THERU_RS02295	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
THERU_RS02300	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
THERU_RS02310	COG0635	Involved in the biosynthesis of porphyrin-containing compound
THERU_RS02315	COG4608	Belongs to the ABC transporter superfamily
THERU_RS02320	COG4536	flavin adenine dinucleotide binding
THERU_RS02325	COG0640	Transcriptional regulator
THERU_RS02340	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
THERU_RS02345	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
THERU_RS02365	COG0534	Mate efflux family protein
THERU_RS02380	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
THERU_RS02390	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
THERU_RS02395	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
THERU_RS02400	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
THERU_RS02405	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
THERU_RS02410	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
THERU_RS02415	COG1706	bacterial-type flagellum-dependent cell motility
THERU_RS02420	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
THERU_RS02425	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
THERU_RS02430	COG1007	ATP synthesis coupled electron transport
THERU_RS02435	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
THERU_RS02445	COG0713	ATP synthesis coupled electron transport
THERU_RS02455	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
THERU_RS02460	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
THERU_RS02465	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
THERU_RS02465	COG0649	NAD binding
THERU_RS02470	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
THERU_RS02475	COG1007	ATP synthesis coupled electron transport
THERU_RS02480	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
THERU_RS02490	COG0713	ATP synthesis coupled electron transport
THERU_RS02500	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
THERU_RS02505	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
THERU_RS02505	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
THERU_RS02510	COG0792	nuclease activity
THERU_RS02515	COG1837	Belongs to the UPF0109 family
THERU_RS02520	COG0228	four-way junction DNA binding
THERU_RS02525	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
THERU_RS02530	COG0149	triose-phosphate isomerase activity
THERU_RS02535	COG0795	lipopolysaccharide-transporting ATPase activity
THERU_RS02540	COG0113	porphobilinogen synthase activity
THERU_RS02545	COG0045	succinate-CoA ligase (ADP-forming) activity
THERU_RS02550	COG0583	DNA-binding transcription factor activity
THERU_RS02560	COG1921	L-seryl-tRNASec selenium transferase activity
THERU_RS02565	COG1305	Transglutaminase-like
THERU_RS02570	COG0709	Synthesizes selenophosphate from selenide and ATP
THERU_RS02575	COG0509	glycine decarboxylation via glycine cleavage system
THERU_RS02580	COG3058	Necessary for formate dehydrogenase activity
THERU_RS02585	COG2032	superoxide dismutase activity
THERU_RS02590	COG2864	formate dehydrogenase
THERU_RS02595	COG0437	4 iron, 4 sulfur cluster binding
THERU_RS02600	COG0243	molybdopterin cofactor binding
THERU_RS02600	COG3383	formate dehydrogenase (NAD+) activity
THERU_RS02605	COG3383	formate dehydrogenase (NAD+) activity
THERU_RS02605	COG0243	molybdopterin cofactor binding
THERU_RS02615	COG1058	Belongs to the CinA family
THERU_RS02615	COG1546	Belongs to the CinA family
THERU_RS02620	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
THERU_RS02625	COG0556	nucleotide-excision repair
THERU_RS02630	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
THERU_RS02635	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
THERU_RS02640	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
THERU_RS02650	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
THERU_RS02650	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
THERU_RS02665	COG0617	tRNA 3'-terminal CCA addition
THERU_RS02670	COG1278	Cold shock
THERU_RS02685	COG0444	Belongs to the ABC transporter superfamily
THERU_RS02690	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
THERU_RS02710	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
THERU_RS02715	COG0436	Aminotransferase
THERU_RS02720	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
THERU_RS02725	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
THERU_RS02735	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
THERU_RS02745	COG0446	pyridine nucleotide-disulphide oxidoreductase
THERU_RS02755	COG1793	dna ligase
THERU_RS02760	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
THERU_RS02775	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
THERU_RS02780	COG0606	chelatase, subunit chli
THERU_RS02785	COG0439	Biotin carboxylase
THERU_RS02800	COG0217	transcriptional regulatory protein
THERU_RS02805	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
THERU_RS02810	COG0504	CTP synthase activity
THERU_RS02820	COG0314	molybdopterin synthase activity
THERU_RS02825	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
THERU_RS02830	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
THERU_RS02845	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
THERU_RS02850	COG1136	(ABC) transporter
THERU_RS02855	COG0284	orotidine-5'-phosphate decarboxylase activity
THERU_RS02865	COG4641	Protein conserved in bacteria
THERU_RS02875	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
THERU_RS02880	COG5000	phosphorelay sensor kinase activity
THERU_RS02905	COG1598	PFAM Uncharacterised protein family UPF0150
THERU_RS02915	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
THERU_RS02920	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
THERU_RS02925	COG0635	Involved in the biosynthesis of porphyrin-containing compound
THERU_RS02930	COG0772	Belongs to the SEDS family
THERU_RS02940	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
THERU_RS02945	COG2067	long-chain fatty acid transport protein
THERU_RS02955	COG1459	type II secretion system
THERU_RS02960	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
THERU_RS02975	COG0131	Imidazoleglycerol-phosphate dehydratase
THERU_RS02980	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
THERU_RS02985	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
THERU_RS02995	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
THERU_RS03000	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
THERU_RS03030	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
THERU_RS03040	COG0242	peptide deformylase activity
THERU_RS03050	COG1333	cytochrome c biogenesis protein
THERU_RS03065	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
THERU_RS03070	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
THERU_RS03075	COG0193	aminoacyl-tRNA hydrolase activity
THERU_RS03085	COG1193	negative regulation of DNA recombination
THERU_RS03090	COG1157	protein secretion by the type III secretion system
THERU_RS03105	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
THERU_RS03110	COG0581	inorganic phosphate transmembrane transporter activity
THERU_RS03135	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
THERU_RS03140	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
THERU_RS03145	COG1830	Aldolase
THERU_RS03155	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
THERU_RS03165	COG0710	3-dehydroquinate dehydratase activity
THERU_RS03170	COG0137	argininosuccinate synthase activity
THERU_RS03175	COG0067	glutamate synthase
THERU_RS03175	COG0070	glutamate synthase
THERU_RS03175	COG0069	glutamate synthase activity
THERU_RS03180	COG0521	Mo-molybdopterin cofactor biosynthetic process
THERU_RS03190	COG0527	aspartate kinase activity
THERU_RS03200	COG0633	Ferredoxin
THERU_RS03205	COG0233	cytoplasmic translational termination
THERU_RS03210	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
THERU_RS03220	COG0440	acetolactate synthase activity
THERU_RS03225	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
THERU_RS03230	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
THERU_RS03235	COG0109	protoheme IX farnesyltransferase activity
THERU_RS03240	COG1612	heme a metabolic process
THERU_RS03255	COG1013	pyruvate-flavodoxin oxidoreductase activity
THERU_RS03270	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
THERU_RS03275	COG0564	pseudouridine synthase activity
THERU_RS03280	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
THERU_RS03285	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
THERU_RS03290	COG1923	regulation of RNA biosynthetic process
THERU_RS03300	COG1692	metallophosphoesterase
THERU_RS03305	COG1028	Short-chain dehydrogenase reductase Sdr
THERU_RS03310	COG0343	queuine tRNA-ribosyltransferase activity
THERU_RS03320	COG1815	bacterial-type flagellum-dependent cell motility
THERU_RS03325	COG1558	bacterial-type flagellum-dependent cell motility
THERU_RS03330	COG1677	Flagellar hook-basal body complex protein FliE
THERU_RS03345	COG1796	DNA polymerase
THERU_RS03345	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
THERU_RS03360	COG0802	atpase or kinase
THERU_RS03370	COG1242	4 iron, 4 sulfur cluster binding
THERU_RS03385	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
THERU_RS03385	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
THERU_RS03390	COG3634	alkyl hydroperoxide reductase activity
THERU_RS03395	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
THERU_RS03405	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
THERU_RS03420	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
THERU_RS03420	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
THERU_RS03425	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
THERU_RS03440	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
THERU_RS03450	COG0546	phosphoglycolate phosphatase activity
THERU_RS03455	COG0583	DNA-binding transcription factor activity
THERU_RS03470	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
THERU_RS03495	COG3746	phosphate-selective porin O and P
THERU_RS03505	COG0617	tRNA 3'-terminal CCA addition
THERU_RS03505	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
THERU_RS03505	COG0517	IMP dehydrogenase activity
THERU_RS03510	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
THERU_RS03525	COG0135	phosphoribosylanthranilate isomerase activity
THERU_RS03530	COG2050	protein possibly involved in aromatic compounds catabolism
THERU_RS03530	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
THERU_RS03540	COG2389	metal-binding protein
THERU_RS03555	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
THERU_RS03560	COG0457	Tetratricopeptide repeat
THERU_RS03560	COG0552	protein localization to endoplasmic reticulum
THERU_RS03565	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
THERU_RS03580	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
THERU_RS03600	COG1561	YicC-like family, N-terminal region
THERU_RS03610	COG0105	UTP biosynthetic process
THERU_RS03615	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
THERU_RS03620	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
THERU_RS03630	COG0698	ribose 5-phosphate isomerase
THERU_RS03635	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
THERU_RS03650	COG0519	Catalyzes the synthesis of GMP from XMP
THERU_RS03650	COG0518	GMP synthase (glutamine-hydrolyzing) activity
THERU_RS03655	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
THERU_RS03665	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
THERU_RS03665	COG1918	ferrous iron import across plasma membrane
THERU_RS03675	COG1424	Catalyzes the transformation of pimelate into pimeloyl- CoA with concomitant hydrolysis of ATP to AMP
THERU_RS03685	COG0165	Argininosuccinate lyase
THERU_RS03695	COG0736	holo-[acyl-carrier-protein] synthase activity
THERU_RS03705	COG0733	neurotransmitter:sodium symporter activity
THERU_RS03720	COG3842	ATPase activity
THERU_RS03740	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
THERU_RS03755	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
THERU_RS03760	COG1496	oxidoreductase activity
THERU_RS03780	COG0134	indole-3-glycerol-phosphate synthase activity
THERU_RS03785	COG0425	Belongs to the sulfur carrier protein TusA family
THERU_RS03815	COG2361	Protein of unknown function DUF86
THERU_RS03830	COG2361	Protein of unknown function DUF86
THERU_RS03860	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
THERU_RS03865	COG0084	hydrolase, TatD family'
THERU_RS03875	COG5016	pyruvate
THERU_RS03875	COG0511	ligase activity, forming carbon-carbon bonds
THERU_RS03880	COG0439	Biotin carboxylase
THERU_RS03895	COG0590	tRNA wobble adenosine to inosine editing
THERU_RS03910	COG2264	protein methyltransferase activity
THERU_RS03915	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
THERU_RS03920	COG0277	FAD linked oxidase domain protein
THERU_RS03960	COG0367	asparagine synthase
THERU_RS03965	COG0438	transferase activity, transferring glycosyl groups
THERU_RS03970	COG1215	transferase activity, transferring glycosyl groups
THERU_RS03975	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
THERU_RS03990	COG2192	nodulation
THERU_RS04015	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
THERU_RS04025	COG2050	protein possibly involved in aromatic compounds catabolism
THERU_RS04025	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
THERU_RS04040	COG2199	diguanylate cyclase activity
THERU_RS04040	COG2200	EAL domain
THERU_RS04040	COG3287	FIST C domain
THERU_RS04045	COG0525	valine-tRNA ligase activity
THERU_RS04050	COG0653	protein targeting
THERU_RS04060	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
THERU_RS04065	COG1136	(ABC) transporter
THERU_RS04065	COG0577	efflux transmembrane transporter activity
THERU_RS04075	COG2322	membrane
THERU_RS04080	COG0741	lytic transglycosylase activity
THERU_RS04085	COG0735	belongs to the Fur family
THERU_RS04090	COG0644	oxidoreductase
THERU_RS04095	COG0776	regulation of translation
THERU_RS04110	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
THERU_RS04115	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
THERU_RS04125	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
THERU_RS04135	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
THERU_RS04155	COG0598	Magnesium transport protein CorA
THERU_RS04170	COG0481	GTPase activity
THERU_RS04180	COG0859	PFAM glycosyl transferase family 9
THERU_RS04195	COG1199	ATP-dependent helicase activity
THERU_RS04200	COG0537	adenosine 5'-monophosphoramidase activity
THERU_RS04205	COG0424	maF-like protein
THERU_RS04210	COG2814	Major facilitator Superfamily
THERU_RS04220	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
THERU_RS04225	COG0825	malonyl-CoA metabolic process
THERU_RS04235	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
THERU_RS04245	COG0187	DNA topoisomerase II activity
THERU_RS04255	COG0542	response to heat
THERU_RS04375	COG1203	CRISPR-associated helicase, Cas3
THERU_RS04385	COG1518	maintenance of DNA repeat elements
THERU_RS04390	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
THERU_RS04410	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
THERU_RS04415	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
THERU_RS04420	COG0824	Thioesterase
THERU_RS04430	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
THERU_RS04440	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
THERU_RS04445	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
THERU_RS04450	COG0227	Belongs to the bacterial ribosomal protein bL28 family
THERU_RS04475	COG0404	The glycine cleavage system catalyzes the degradation of glycine
THERU_RS04480	COG0037	tRNA processing
THERU_RS04490	COG0012	GTP binding
THERU_RS04515	COG1349	DNA-binding transcription factor activity
THERU_RS04520	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
THERU_RS04530	COG5002	protein histidine kinase activity
THERU_RS04545	COG0243	molybdopterin cofactor binding
THERU_RS04550	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
THERU_RS04555	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
THERU_RS04560	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
THERU_RS04565	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
THERU_RS04570	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
THERU_RS04570	COG1116	anion transmembrane transporter activity
THERU_RS04575	COG0243	molybdopterin cofactor binding
THERU_RS04585	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
THERU_RS04605	COG0737	Belongs to the 5'-nucleotidase family
THERU_RS04640	COG0123	including yeast histone deacetylase and acetoin utilization protein
THERU_RS04645	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
THERU_RS04655	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
THERU_RS04660	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
THERU_RS04665	COG2877	3-deoxy-8-phosphooctulonate synthase activity
THERU_RS04675	COG1509	lysine 2,3-aminomutase activity
THERU_RS04685	COG0322	excinuclease ABC activity
THERU_RS04690	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
THERU_RS04695	COG0298	carbon dioxide binding
THERU_RS04700	COG0409	Hydrogenase expression formation protein
THERU_RS04705	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
THERU_RS04705	COG1024	Enoyl-CoA hydratase
THERU_RS04715	COG1122	ATPase activity
THERU_RS04725	COG0310	cobalt ion transport
THERU_RS04745	COG0864	Transcriptional regulator
THERU_RS04760	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
THERU_RS04765	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
THERU_RS04775	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
THERU_RS04780	COG0375	protein maturation
THERU_RS04865	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
THERU_RS04870	COG2046	Belongs to the sulfate adenylyltransferase family
THERU_RS04875	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
THERU_RS04890	COG0175	sulfate reduction
THERU_RS04895	COG2204	response regulator
THERU_RS04945	COG1192	Involved in chromosome partitioning
THERU_RS04960	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
THERU_RS04965	COG0714	Associated with various cellular activities
THERU_RS04970	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
THERU_RS04975	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
THERU_RS04980	COG0322	excinuclease ABC activity
THERU_RS05015	COG2105	PFAM AIG2 family protein
THERU_RS05040	COG0492	ferredoxin-NADP+ reductase activity
THERU_RS05050	COG0107	imidazoleglycerol-phosphate synthase activity
THERU_RS05065	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
THERU_RS05080	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
THERU_RS05090	COG1187	pseudouridine synthase activity
THERU_RS05095	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
THERU_RS05100	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
THERU_RS05105	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
THERU_RS05105	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
THERU_RS05110	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
THERU_RS05135	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
THERU_RS05140	COG0039	L-malate dehydrogenase activity
THERU_RS05150	COG0751	glycine-tRNA ligase activity
THERU_RS05155	COG0574	Belongs to the PEP-utilizing enzyme family
THERU_RS05155	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
THERU_RS05180	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
THERU_RS05185	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
THERU_RS05190	COG1388	LysM domain
THERU_RS05190	COG1705	Flagellar rod assembly protein muramidase FlgJ
THERU_RS05195	COG1254	Belongs to the acylphosphatase family
THERU_RS05200	COG1477	protein flavinylation
THERU_RS05215	COG1730	sister chromatid segregation
THERU_RS05220	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
THERU_RS05225	COG1331	Highly conserved protein containing a thioredoxin domain
THERU_RS05230	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
THERU_RS05235	COG0351	phosphomethylpyrimidine kinase
THERU_RS05245	COG0251	oxidation-reduction process
THERU_RS05250	COG0752	glycyl-tRNA synthetase alpha subunit
THERU_RS05255	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
THERU_RS05265	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
THERU_RS05270	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
THERU_RS05270	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
THERU_RS05275	COG0159	tryptophan synthase activity
THERU_RS05285	COG1592	Rubrerythrin
THERU_RS05300	COG0439	Biotin carboxylase
THERU_RS05305	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
THERU_RS05310	COG0649	NAD binding
THERU_RS05310	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
THERU_RS05315	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
THERU_RS05330	COG0018	arginyl-trna synthetase
THERU_RS05335	COG0151	Belongs to the GarS family
THERU_RS05340	COG2084	Dehydrogenase
THERU_RS05345	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
THERU_RS05350	COG1104	cysteine desulfurase activity
THERU_RS05355	COG0489	protein tyrosine kinase activity
THERU_RS05365	COG0142	geranyltranstransferase activity
THERU_RS05390	COG0717	Belongs to the dCTP deaminase family
THERU_RS05405	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
THERU_RS05410	COG1100	Small GTP-binding protein
THERU_RS05420	COG0745	RESPONSE REGULATOR receiver
THERU_RS05435	COG0148	phosphopyruvate hydratase activity
THERU_RS05440	COG0352	thiamine-phosphate diphosphorylase activity
THERU_RS05460	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
THERU_RS05460	COG1565	acr, cog1565
THERU_RS05465	COG1845	cytochrome c oxidase, subunit III
THERU_RS05465	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
THERU_RS05475	COG0052	Belongs to the universal ribosomal protein uS2 family
THERU_RS05480	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
THERU_RS05490	COG1872	DUF167
THERU_RS05495	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
THERU_RS05500	COG0215	cysteine-tRNA ligase activity
THERU_RS05505	COG0303	'Molybdopterin
THERU_RS05510	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
THERU_RS05515	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
THERU_RS05520	COG3706	GGDEF domain
THERU_RS05525	COG0095	Lipoate-protein ligase
THERU_RS05530	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
THERU_RS05535	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
THERU_RS05550	COG0544	peptidyl-prolyl cis-trans isomerase activity
THERU_RS05555	COG0740	serine-type endopeptidase activity
THERU_RS05560	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
THERU_RS05570	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
THERU_RS05575	COG0438	transferase activity, transferring glycosyl groups
THERU_RS05620	COG4969	Belongs to the N-Me-Phe pilin family
THERU_RS05640	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
THERU_RS05645	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
THERU_RS05665	COG0237	dephospho-CoA kinase activity
THERU_RS05670	COG0037	tRNA processing
THERU_RS05695	COG3604	Transcriptional regulator
THERU_RS05705	COG0850	regulation of cytokinetic process
THERU_RS05710	COG2894	cell division
THERU_RS05715	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
THERU_RS05725	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
THERU_RS05740	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
THERU_RS05770	COG0438	transferase activity, transferring glycosyl groups
THERU_RS05780	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
THERU_RS05790	COG0495	leucyl-tRNA aminoacylation
THERU_RS05795	COG0822	iron-sulfur transferase activity
THERU_RS05800	COG0482	sulfurtransferase activity
THERU_RS05805	COG0425	Belongs to the sulfur carrier protein TusA family
THERU_RS05820	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
THERU_RS05825	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
THERU_RS05830	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
THERU_RS05835	COG5001	Diguanylate cyclase
THERU_RS05835	COG5002	protein histidine kinase activity
THERU_RS05840	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
THERU_RS05850	COG0163	prenyltransferase activity
THERU_RS05855	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
THERU_RS05860	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
THERU_RS05865	COG0363	glucosamine-6-phosphate deaminase activity
THERU_RS05870	COG2270	Major facilitator Superfamily
THERU_RS05880	COG1458	PINc domain ribonuclease
THERU_RS05885	COG0316	Belongs to the HesB IscA family
THERU_RS05895	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
THERU_RS05905	COG0745	RESPONSE REGULATOR receiver
THERU_RS05910	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
THERU_RS05915	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
THERU_RS05920	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
THERU_RS05935	COG0848	biopolymer transport protein
THERU_RS05955	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
THERU_RS05960	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
THERU_RS05965	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
THERU_RS05970	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
THERU_RS05985	COG0571	ribonuclease III activity
THERU_RS05990	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
THERU_RS05995	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
THERU_RS06005	COG0728	peptidoglycan biosynthetic process
THERU_RS06010	COG0268	Binds directly to 16S ribosomal RNA
THERU_RS06015	COG4654	Cytochrome c, class I
THERU_RS06020	COG0446	pyridine nucleotide-disulphide oxidoreductase
THERU_RS06025	COG0705	Rhomboid family
THERU_RS06040	COG3706	GGDEF domain
THERU_RS06045	COG0812	UDP-N-acetylmuramate dehydrogenase activity
THERU_RS06050	COG1181	Belongs to the D-alanine--D-alanine ligase family
THERU_RS06065	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
THERU_RS06080	COG0589	response to stress
THERU_RS06085	COG0483	inositol monophosphate 1-phosphatase activity
THERU_RS06090	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
THERU_RS06095	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
THERU_RS06100	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
THERU_RS06105	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
THERU_RS06115	COG0457	Tetratricopeptide repeat
THERU_RS06130	COG2217	Heavy metal translocating P-type atpase
THERU_RS06135	COG1191	sigma factor activity
THERU_RS06140	COG0291	Belongs to the bacterial ribosomal protein bL35 family
THERU_RS06165	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
THERU_RS06170	COG0095	Lipoate-protein ligase
THERU_RS06175	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
THERU_RS06190	COG0811	peptide transport
THERU_RS06200	COG0406	alpha-ribazole phosphatase activity
THERU_RS06205	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
THERU_RS06210	COG1260	myo-inositol-1-phosphate synthase
THERU_RS06220	COG0497	DNA recombination
THERU_RS06225	COG1059	Responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine 7-oxoG) from DNA. Also nicks DNA at apurinic apyrimidinic sites (AP sites)
THERU_RS06230	COG0003	Pfam Anion-transporting ATPase
THERU_RS06240	COG4654	Cytochrome c, class I
THERU_RS06245	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
THERU_RS06250	COG1490	D-aminoacyl-tRNA deacylase activity
THERU_RS06275	COG0505	Belongs to the CarA family
THERU_RS06280	COG0768	penicillin binding
THERU_RS06285	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
THERU_RS06290	COG0616	signal peptide processing
THERU_RS06315	COG1459	type II secretion system
THERU_RS06325	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
THERU_RS06330	COG0495	leucyl-tRNA aminoacylation
THERU_RS06340	COG0674	pyruvate-flavodoxin oxidoreductase activity
THERU_RS06345	COG1013	pyruvate-flavodoxin oxidoreductase activity
THERU_RS06365	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
THERU_RS06370	COG3002	Belongs to the UPF0753 family
THERU_RS06385	COG0335	large ribosomal subunit rRNA binding
THERU_RS06390	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
THERU_RS06395	COG0275	rRNA processing
THERU_RS06415	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
THERU_RS06425	COG4274	PFAM GYD family protein
THERU_RS06450	COG3302	dmso reductase anchor subunit
THERU_RS06455	COG0437	4 iron, 4 sulfur cluster binding
THERU_RS06470	COG0243	molybdopterin cofactor binding
THERU_RS06500	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
THERU_RS06520	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
THERU_RS06530	COG2608	mercury ion transmembrane transporter activity
THERU_RS06560	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
THERU_RS06570	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
THERU_RS06605	COG0741	lytic transglycosylase activity
THERU_RS06610	COG0307	riboflavin synthase, alpha
THERU_RS06615	COG0543	2 iron, 2 sulfur cluster binding
THERU_RS06620	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
THERU_RS06630	COG0702	epimerase
THERU_RS06635	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
THERU_RS06650	COG0156	8-amino-7-oxononanoate synthase activity
THERU_RS06655	COG1749	Flagellar hook protein flgE
THERU_RS06675	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
THERU_RS06675	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
THERU_RS06680	COG1980	fructose-bisphosphate aldolase activity
THERU_RS06690	COG1110	DNA topoisomerase II activity
THERU_RS06695	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
THERU_RS06700	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
THERU_RS06705	COG0459	protein refolding
THERU_RS06715	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
THERU_RS06720	COG3956	TIGRFAM MazG family protein
THERU_RS06725	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
THERU_RS06730	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
THERU_RS06740	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
THERU_RS06750	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
THERU_RS06755	COG0544	peptidyl-prolyl cis-trans isomerase activity
THERU_RS06760	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
THERU_RS06765	COG0390	transport system, permease component
THERU_RS06770	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
THERU_RS06775	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
THERU_RS06795	COG0778	Nitroreductase
THERU_RS06800	COG0477	Major facilitator Superfamily
THERU_RS06810	COG1924	4 iron, 4 sulfur cluster binding
THERU_RS06825	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
THERU_RS06830	COG0126	phosphoglycerate kinase activity
THERU_RS06845	COG0519	Catalyzes the synthesis of GMP from XMP
THERU_RS06845	COG0518	GMP synthase (glutamine-hydrolyzing) activity
THERU_RS06850	COG1011	Hydrolase
THERU_RS06860	COG0004	ammonium transporteR
THERU_RS06865	COG0174	glutamine synthetase
THERU_RS06870	COG0347	Belongs to the P(II) protein family
THERU_RS06880	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
THERU_RS06885	COG0066	3-isopropylmalate dehydratase activity
THERU_RS06895	COG0592	DNA-directed DNA polymerase activity
THERU_RS06900	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
THERU_RS06910	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
THERU_RS06915	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
THERU_RS06920	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
THERU_RS06925	COG0463	Glycosyl transferase, family 2
THERU_RS06930	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
THERU_RS06930	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
THERU_RS06940	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
THERU_RS06945	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
THERU_RS06955	COG2226	methyltransferase
THERU_RS06960	COG0211	Belongs to the bacterial ribosomal protein bL27 family
THERU_RS06965	COG0261	This protein binds to 23S rRNA in the presence of protein L20
THERU_RS06975	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
THERU_RS06980	COG0493	'glutamate synthase
THERU_RS06995	COG0772	Belongs to the SEDS family
THERU_RS07000	COG1519	Transferase
THERU_RS07015	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
THERU_RS07015	COG0517	IMP dehydrogenase activity
THERU_RS07050	COG0267	Belongs to the bacterial ribosomal protein bL33 family
THERU_RS07065	COG0250	Participates in transcription elongation, termination and antitermination
THERU_RS07070	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
THERU_RS07075	COG0081	regulation of translation
THERU_RS07080	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
THERU_RS07085	COG0222	ribosome binding
THERU_RS07090	COG0085	RNA polymerase activity
THERU_RS07095	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
THERU_RS07100	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
THERU_RS07105	COG0049	tRNA binding
THERU_RS07110	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
THERU_RS07120	COG0051	transcription antitermination factor activity, RNA binding
THERU_RS07125	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
THERU_RS07130	COG0088	Forms part of the polypeptide exit tunnel
THERU_RS07135	COG0089	rRNA binding
THERU_RS07140	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
THERU_RS07145	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
THERU_RS07150	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
THERU_RS07155	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
THERU_RS07160	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
THERU_RS07170	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
THERU_RS07185	COG1053	succinate dehydrogenase
THERU_RS07190	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
THERU_RS07195	COG1640	4-alpha-glucanotransferase
THERU_RS07210	COG1137	ATPase activity
THERU_RS07215	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
THERU_RS07220	COG0336	Belongs to the RNA methyltransferase TrmD family
THERU_RS07225	COG4974	Belongs to the 'phage' integrase family
THERU_RS07250	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
THERU_RS07255	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
THERU_RS07260	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
THERU_RS07270	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
THERU_RS07275	COG0509	glycine decarboxylation via glycine cleavage system
THERU_RS07280	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
THERU_RS07285	COG0820	rRNA (adenine-C2-)-methyltransferase activity
THERU_RS07290	COG1774	PSP1 C-terminal conserved region
THERU_RS07295	COG0470	DNA polymerase III
THERU_RS07300	COG0302	gtp cyclohydrolase
THERU_RS07305	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
THERU_RS07310	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
THERU_RS07315	COG1702	phosphate starvation-inducible protein PhoH
THERU_RS07320	COG0540	Belongs to the ATCase OTCase family
THERU_RS07335	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
THERU_RS07340	COG0815	Transfers the fatty acyl group on membrane lipoproteins
THERU_RS07355	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
THERU_RS07365	COG0218	Necessary for normal cell division and for the maintenance of normal septation
THERU_RS07370	COG0285	dihydrofolate synthase activity
THERU_RS07375	COG0557	exoribonuclease II activity
THERU_RS07380	COG1454	alcohol dehydrogenase
THERU_RS07385	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
THERU_RS07395	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
THERU_RS07400	COG0358	DNA primase activity
THERU_RS07405	COG0101	tRNA pseudouridine synthase activity
THERU_RS07420	COG0300	oxidoreductase activity
THERU_RS07430	COG0315	cyclic pyranopterin monophosphate synthase activity
THERU_RS07440	COG0019	diaminopimelate decarboxylase activity
THERU_RS07450	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
THERU_RS07460	COG0655	NAD(P)H dehydrogenase (quinone) activity
THERU_RS07465	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
THERU_RS07470	COG0195	Participates in both transcription termination and antitermination
THERU_RS07475	COG0779	Required for maturation of 30S ribosomal subunits
THERU_RS07485	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
THERU_RS07495	COG0601	transmembrane transport
THERU_RS07500	COG0693	protein deglycase activity
THERU_RS07505	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
THERU_RS07510	COG1132	(ABC) transporter
THERU_RS07515	COG0484	heat shock protein binding
THERU_RS07525	COG1144	Oxidoreductase
THERU_RS07530	COG0436	Aminotransferase
THERU_RS07535	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
THERU_RS07555	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
THERU_RS07560	COG1127	ABC transporter
THERU_RS07565	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
THERU_RS07570	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
THERU_RS07580	COG1276	copper resistance
THERU_RS07595	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
THERU_RS07600	COG0333	Belongs to the bacterial ribosomal protein bL32 family
THERU_RS07605	COG0416	fatty acid biosynthetic process
THERU_RS07610	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
THERU_RS07615	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
THERU_RS07625	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
THERU_RS07640	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
THERU_RS07645	COG0359	binds to the 23S rRNA
THERU_RS07650	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
THERU_RS07655	COG0629	single-stranded DNA binding
THERU_RS07660	COG0360	Binds together with S18 to 16S ribosomal RNA
THERU_RS07665	COG0140	phosphoribosyl-ATP diphosphatase activity
THERU_RS07665	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
THERU_RS07675	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
THERU_RS07680	COG0167	dihydroorotate dehydrogenase activity
THERU_RS07695	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
THERU_RS07700	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
THERU_RS07705	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
THERU_RS07710	COG1160	GTP binding
THERU_RS07715	COG1408	metallophosphoesterase
THERU_RS07720	COG0745	RESPONSE REGULATOR receiver
THERU_RS07725	COG5016	pyruvate
THERU_RS07725	COG0511	ligase activity, forming carbon-carbon bonds
THERU_RS07730	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
THERU_RS07735	COG0511	ligase activity, forming carbon-carbon bonds
THERU_RS07745	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
THERU_RS07750	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
THERU_RS07755	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
THERU_RS07780	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
THERU_RS07785	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
THERU_RS07795	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
THERU_RS07800	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
THERU_RS07820	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
THERU_RS07825	COG0354	folic acid binding
THERU_RS07830	COG0644	oxidoreductase
THERU_RS07840	COG1867	N(2),N(2)-dimethylguanosine tRNA methyltransferase
THERU_RS07845	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
THERU_RS07875	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
THERU_RS07885	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
THERU_RS07895	COG2022	thiamine diphosphate biosynthetic process
THERU_RS07905	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
THERU_RS07905	COG1648	precorrin-2 dehydrogenase activity
THERU_RS07930	COG0006	proline dipeptidase activity
THERU_RS07940	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
THERU_RS07945	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
THERU_RS07950	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
THERU_RS07955	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
THERU_RS07960	COG1355	regulation of microtubule-based process
THERU_RS07970	COG0072	phenylalanine-tRNA ligase activity
THERU_RS07970	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
THERU_RS07975	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
THERU_RS07980	COG1418	mRNA catabolic process
THERU_RS07980	COG3599	regulation of cell shape
THERU_RS07985	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
THERU_RS07990	COG0791	NLP P60 protein
THERU_RS07995	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
THERU_RS08010	COG2154	pterin-4-alpha-carbinolamine dehydratase
THERU_RS08030	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
THERU_RS08035	COG1684	flagellar biosynthetic protein fliR
THERU_RS08040	COG1987	bacterial-type flagellum assembly
THERU_RS08045	COG1338	Plays a role in the flagellum-specific transport system
THERU_RS08055	COG1580	Controls the rotational direction of flagella during chemotaxis
THERU_RS08060	COG0312	modulator of DNA gyrase
THERU_RS08070	COG0745	RESPONSE REGULATOR receiver
THERU_RS08075	COG0747	negative chemotaxis
THERU_RS08080	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
THERU_RS08085	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
THERU_RS08090	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
THERU_RS08095	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
THERU_RS08100	COG1419	protein localization to endoplasmic reticulum
THERU_RS08110	COG4752	Belongs to the RNA methyltransferase TrmD family
THERU_RS08115	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
THERU_RS08120	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
THERU_RS08125	COG0142	geranyltranstransferase activity
THERU_RS08130	COG1196	nuclear chromosome segregation
THERU_RS08135	COG0542	response to heat
THERU_RS08145	COG4783	chaperone-mediated protein folding
THERU_RS08155	COG0357	Ribosomal RNA small subunit methyltransferase G
THERU_RS08170	COG0482	sulfurtransferase activity
THERU_RS08180	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
THERU_RS08190	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
THERU_RS08195	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
THERU_RS08205	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
THERU_RS08205	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
THERU_RS08210	COG0538	isocitrate dehydrogenase activity
THERU_RS08215	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
THERU_RS08220	COG0803	Belongs to the bacterial solute-binding protein 9 family
THERU_RS08220	COG3443	Belongs to the bacterial solute-binding protein 9 family
THERU_RS08225	COG1121	(ABC) transporter
THERU_RS08230	COG1108	ABC-type Mn2 Zn2 transport systems permease components
THERU_RS08235	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
THERU_RS08245	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
THERU_RS08245	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
THERU_RS08250	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
THERU_RS08255	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
THERU_RS08270	COG0667	Aldo Keto reductase
THERU_RS08275	COG1185	polyribonucleotide nucleotidyltransferase activity
THERU_RS08280	COG5002	protein histidine kinase activity
THERU_RS08280	COG5001	Diguanylate cyclase
THERU_RS08285	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
THERU_RS08320	COG3439	Domain of unknown function DUF302
THERU_RS08325	COG2010	Cytochrome c
THERU_RS08360	COG0811	peptide transport
THERU_RS08375	COG0746	molybdenum cofactor guanylyltransferase activity
THERU_RS08380	COG0402	S-adenosylhomocysteine deaminase activity