locus-tag	class	description
THEIN_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
THEIN_RS00010	COG0277	FAD linked oxidase domain protein
THEIN_RS00015	COG4771	TonB-dependent receptor
THEIN_RS00025	COG3852	Histidine kinase
THEIN_RS00030	COG0129	dihydroxy-acid dehydratase activity
THEIN_RS00035	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
THEIN_RS00045	COG0484	heat shock protein binding
THEIN_RS00050	COG0315	cyclic pyranopterin monophosphate synthase activity
THEIN_RS00080	COG2204	response regulator
THEIN_RS00090	COG1530	ribonuclease E activity
THEIN_RS00120	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
THEIN_RS00120	COG0574	Belongs to the PEP-utilizing enzyme family
THEIN_RS00130	COG3437	response regulator, receiver
THEIN_RS00130	COG2770	Histidine kinase
THEIN_RS00140	COG0156	8-amino-7-oxononanoate synthase activity
THEIN_RS00155	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
THEIN_RS00180	COG0358	DNA primase activity
THEIN_RS00185	COG1193	negative regulation of DNA recombination
THEIN_RS00190	COG0828	Belongs to the bacterial ribosomal protein bS21 family
THEIN_RS00195	COG0009	L-threonylcarbamoyladenylate synthase
THEIN_RS00205	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
THEIN_RS00205	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
THEIN_RS00215	COG2226	methyltransferase
THEIN_RS00220	COG0436	Aminotransferase
THEIN_RS00225	COG2715	membrane protein required for spore maturation
THEIN_RS00230	COG1691	(AIR) carboxylase
THEIN_RS00240	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
THEIN_RS00245	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
THEIN_RS00245	COG0475	glutathione-regulated potassium exporter activity
THEIN_RS00250	COG0166	Belongs to the GPI family
THEIN_RS00280	COG0425	Belongs to the sulfur carrier protein TusA family
THEIN_RS00300	COG1522	sequence-specific DNA binding
THEIN_RS00305	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
THEIN_RS00325	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
THEIN_RS00330	COG1785	Belongs to the alkaline phosphatase family
THEIN_RS00355	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
THEIN_RS00365	COG1285	pathogenesis
THEIN_RS00370	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
THEIN_RS00380	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
THEIN_RS00385	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
THEIN_RS00390	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
THEIN_RS00395	COG2204	response regulator
THEIN_RS00410	COG0220	tRNA (guanine-N7-)-methyltransferase activity
THEIN_RS00410	COG1519	Transferase
THEIN_RS00415	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
THEIN_RS00420	COG0194	GDP metabolic process
THEIN_RS00425	COG2052	Domain of unknown function (DUF370)
THEIN_RS00430	COG1561	YicC-like family, N-terminal region
THEIN_RS00440	COG2885	chlorophyll binding
THEIN_RS00450	COG0837	glucose binding
THEIN_RS00460	COG0728	peptidoglycan biosynthetic process
THEIN_RS00485	COG0735	belongs to the Fur family
THEIN_RS00505	COG0612	Peptidase, M16
THEIN_RS00510	COG0489	protein tyrosine kinase activity
THEIN_RS00520	COG0247	lactate metabolic process
THEIN_RS00530	COG1397	ADP-ribosylglycohydrolase
THEIN_RS00540	COG4106	trans-aconitate 2-methyltransferase activity
THEIN_RS00570	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
THEIN_RS00580	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
THEIN_RS00585	COG1214	PFAM Peptidase M22, glycoprotease
THEIN_RS00590	COG0601	transmembrane transport
THEIN_RS00595	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
THEIN_RS00600	COG0071	Belongs to the small heat shock protein (HSP20) family
THEIN_RS00610	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
THEIN_RS00625	COG1328	CTP reductase activity
THEIN_RS00625	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
THEIN_RS00630	COG0803	Belongs to the bacterial solute-binding protein 9 family
THEIN_RS00635	COG1213	nucleotidyl transferase
THEIN_RS00635	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
THEIN_RS00645	COG4191	Histidine kinase
THEIN_RS00650	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
THEIN_RS00655	COG0509	glycine decarboxylation via glycine cleavage system
THEIN_RS00660	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
THEIN_RS00670	COG2835	tetraacyldisaccharide 4'-kinase activity
THEIN_RS00685	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
THEIN_RS00715	COG0019	diaminopimelate decarboxylase activity
THEIN_RS00720	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
THEIN_RS00735	COG0616	signal peptide processing
THEIN_RS00740	COG0248	Ppx GppA phosphatase
THEIN_RS00745	COG0516	GMP reductase activity
THEIN_RS00745	COG0517	IMP dehydrogenase activity
THEIN_RS00750	COG1459	type II secretion system
THEIN_RS00760	COG0484	heat shock protein binding
THEIN_RS00765	COG1519	Transferase
THEIN_RS00765	COG0220	tRNA (guanine-N7-)-methyltransferase activity
THEIN_RS00770	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
THEIN_RS00775	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
THEIN_RS00785	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
THEIN_RS00790	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
THEIN_RS00830	COG0789	Transcriptional regulator
THEIN_RS00850	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
THEIN_RS00855	COG1067	ATP-dependent peptidase activity
THEIN_RS00865	COG1522	sequence-specific DNA binding
THEIN_RS00870	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
THEIN_RS00875	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
THEIN_RS00880	COG0163	prenyltransferase activity
THEIN_RS00890	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
THEIN_RS00890	COG1648	precorrin-2 dehydrogenase activity
THEIN_RS00900	COG1580	Controls the rotational direction of flagella during chemotaxis
THEIN_RS00920	COG1338	Plays a role in the flagellum-specific transport system
THEIN_RS00925	COG1987	bacterial-type flagellum assembly
THEIN_RS00930	COG1684	flagellar biosynthetic protein fliR
THEIN_RS00935	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
THEIN_RS00940	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
THEIN_RS00945	COG1419	protein localization to endoplasmic reticulum
THEIN_RS00955	COG1191	sigma factor activity
THEIN_RS00990	COG1959	2 iron, 2 sulfur cluster binding
THEIN_RS01000	COG1047	Peptidyl-prolyl cis-trans
THEIN_RS01005	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
THEIN_RS01015	COG0004	ammonium transporteR
THEIN_RS01020	COG0347	Belongs to the P(II) protein family
THEIN_RS01040	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
THEIN_RS01045	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
THEIN_RS01050	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
THEIN_RS01060	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
THEIN_RS01060	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
THEIN_RS01070	COG0195	Participates in both transcription termination and antitermination
THEIN_RS01075	COG0779	Required for maturation of 30S ribosomal subunits
THEIN_RS01155	COG1203	CRISPR-associated helicase, Cas3
THEIN_RS01170	COG1518	maintenance of DNA repeat elements
THEIN_RS01175	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
THEIN_RS01200	COG0730	response to heat
THEIN_RS01230	COG0557	exoribonuclease II activity
THEIN_RS01240	COG0537	adenosine 5'-monophosphoramidase activity
THEIN_RS01255	COG0242	peptide deformylase activity
THEIN_RS01280	COG0473	3-isopropylmalate dehydrogenase activity
THEIN_RS01285	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
THEIN_RS01300	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
THEIN_RS01325	COG1181	Belongs to the D-alanine--D-alanine ligase family
THEIN_RS01335	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
THEIN_RS01340	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
THEIN_RS01345	COG1515	deoxyribonuclease V activity
THEIN_RS01350	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
THEIN_RS01385	COG0085	RNA polymerase activity
THEIN_RS01390	COG0222	ribosome binding
THEIN_RS01395	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
THEIN_RS01400	COG0081	regulation of translation
THEIN_RS01405	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
THEIN_RS01425	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
THEIN_RS01455	COG1233	COG1233 Phytoene dehydrogenase and related
THEIN_RS01470	COG0746	molybdenum cofactor guanylyltransferase activity
THEIN_RS01480	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
THEIN_RS01485	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
THEIN_RS01495	COG0298	carbon dioxide binding
THEIN_RS01500	COG0375	protein maturation
THEIN_RS01510	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
THEIN_RS01515	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
THEIN_RS01520	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
THEIN_RS01525	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
THEIN_RS01545	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
THEIN_RS01550	COG0527	aspartate kinase activity
THEIN_RS01555	COG0484	heat shock protein binding
THEIN_RS01595	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
THEIN_RS01605	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
THEIN_RS01615	COG1910	domain protein
THEIN_RS01620	COG2998	abc-type tungstate transport system, permease component
THEIN_RS01625	COG4662	Binding-protein-dependent transport system inner membrane component
THEIN_RS01645	COG2204	response regulator
THEIN_RS01650	COG4191	Histidine kinase
THEIN_RS01670	COG0589	response to stress
THEIN_RS01690	COG0589	response to stress
THEIN_RS01700	COG0589	response to stress
THEIN_RS01705	COG1227	inorganic diphosphatase activity
THEIN_RS01725	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
THEIN_RS01730	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
THEIN_RS01735	COG2199	diguanylate cyclase activity
THEIN_RS01750	COG0835	chemotaxis
THEIN_RS01755	COG0484	heat shock protein binding
THEIN_RS01760	COG0643	Histidine kinase
THEIN_RS01760	COG0784	Response regulator, receiver
THEIN_RS01760	COG2198	Histidine kinase
THEIN_RS01765	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
THEIN_RS01770	COG2201	protein-glutamate methylesterase activity
THEIN_RS01775	COG0745	RESPONSE REGULATOR receiver
THEIN_RS01780	COG0736	holo-[acyl-carrier-protein] synthase activity
THEIN_RS01785	COG0857	belongs to the CobB CobQ family
THEIN_RS01820	COG0710	3-dehydroquinate dehydratase activity
THEIN_RS01825	COG0138	bifunctional purine biosynthesis protein purh
THEIN_RS01830	COG0535	radical SAM domain protein
THEIN_RS01835	COG0784	Response regulator, receiver
THEIN_RS01840	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
THEIN_RS01845	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
THEIN_RS01850	COG0084	hydrolase, TatD family'
THEIN_RS01870	COG0823	Involved in the tonB-independent uptake of proteins
THEIN_RS01875	COG1960	acyl-CoA dehydrogenase activity
THEIN_RS01880	COG2086	electron transfer activity
THEIN_RS01885	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
THEIN_RS01895	COG1028	Short-chain dehydrogenase reductase Sdr
THEIN_RS01910	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
THEIN_RS01915	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
THEIN_RS01920	COG0698	ribose 5-phosphate isomerase
THEIN_RS01925	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
THEIN_RS01930	COG2131	deaminase
THEIN_RS01940	COG0765	amino acid transport
THEIN_RS01945	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
THEIN_RS01950	COG1794	racemase activity, acting on amino acids and derivatives
THEIN_RS01955	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
THEIN_RS01965	COG0288	reversible hydration of carbon dioxide
THEIN_RS02000	COG0745	RESPONSE REGULATOR receiver
THEIN_RS02005	COG0307	riboflavin synthase, alpha
THEIN_RS02010	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
THEIN_RS02035	COG2221	Nitrite and sulphite reductase 4Fe-4S
THEIN_RS02040	COG2221	Nitrite and sulphite reductase 4Fe-4S
THEIN_RS02055	COG1100	Small GTP-binding protein
THEIN_RS02065	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
THEIN_RS02070	COG5002	protein histidine kinase activity
THEIN_RS02090	COG2855	membrane
THEIN_RS02100	COG1234	tRNA 3'-trailer cleavage
THEIN_RS02155	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
THEIN_RS02165	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
THEIN_RS02170	COG0812	UDP-N-acetylmuramate dehydrogenase activity
THEIN_RS02175	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
THEIN_RS02180	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
THEIN_RS02185	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
THEIN_RS02190	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
THEIN_RS02195	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
THEIN_RS02200	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
THEIN_RS02215	COG0275	rRNA processing
THEIN_RS02220	COG2001	Belongs to the MraZ family
THEIN_RS02235	COG1086	Polysaccharide biosynthesis protein
THEIN_RS02245	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
THEIN_RS02250	COG3980	spore coat polysaccharide biosynthesis protein
THEIN_RS02255	COG2089	acid synthase
THEIN_RS02265	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
THEIN_RS02285	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
THEIN_RS02295	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
THEIN_RS02300	COG1256	bacterial-type flagellum assembly
THEIN_RS02300	COG4786	Flagellar basal body rod
THEIN_RS02300	COG1256	bacterial-type flagellum assembly
THEIN_RS02300	COG4786	Flagellar basal body rod
THEIN_RS02315	COG1706	bacterial-type flagellum-dependent cell motility
THEIN_RS02320	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
THEIN_RS02330	COG4786	Flagellar basal body rod
THEIN_RS02335	COG4786	Flagellar basal body rod
THEIN_RS02345	COG0489	protein tyrosine kinase activity
THEIN_RS02345	COG0489	protein tyrosine kinase activity
THEIN_RS02350	COG2894	cell division
THEIN_RS02360	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
THEIN_RS02365	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
THEIN_RS02370	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
THEIN_RS02375	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
THEIN_RS02390	COG0390	transport system, permease component
THEIN_RS02400	COG1210	Utp--glucose-1-phosphate uridylyltransferase
THEIN_RS02405	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
THEIN_RS02410	COG0805	protein transport
THEIN_RS02415	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
THEIN_RS02420	COG4191	Histidine kinase
THEIN_RS02435	COG3842	ATPase activity
THEIN_RS02450	COG0725	ABC transporter, periplasmic molybdate-binding protein
THEIN_RS02455	COG1027	Aspartate ammonia-lyase
THEIN_RS02490	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
THEIN_RS02490	COG4624	Iron only hydrogenase large subunit, C-terminal domain
THEIN_RS02495	COG1160	GTP binding
THEIN_RS02500	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
THEIN_RS02510	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
THEIN_RS02515	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
THEIN_RS02520	COG1120	ATPase activity
THEIN_RS02565	COG0037	tRNA processing
THEIN_RS02570	COG1295	ribonuclease BN
THEIN_RS02600	COG0481	GTPase activity
THEIN_RS02605	COG0681	Belongs to the peptidase S26 family
THEIN_RS02615	COG2203	Gaf domain
THEIN_RS02615	COG2199	diguanylate cyclase activity
THEIN_RS02630	COG0154	amidase activity
THEIN_RS02640	COG0351	phosphomethylpyrimidine kinase
THEIN_RS02680	COG0247	lactate metabolic process
THEIN_RS02685	COG0482	sulfurtransferase activity
THEIN_RS02695	COG0688	phosphatidylethanolamine metabolic process
THEIN_RS02700	COG1183	phosphatidylcholine synthase activity
THEIN_RS02705	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
THEIN_RS02710	COG0784	Response regulator, receiver
THEIN_RS02710	COG4191	Histidine kinase
THEIN_RS02715	COG0443	Heat shock 70 kDa protein
THEIN_RS02720	COG0776	regulation of translation
THEIN_RS02730	COG0765	amino acid transport
THEIN_RS02735	COG0765	amino acid transport
THEIN_RS02740	COG1126	abc transporter atp-binding protein
THEIN_RS02755	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
THEIN_RS02775	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
THEIN_RS02780	COG0254	rRNA binding
THEIN_RS02790	COG0167	dihydroorotate dehydrogenase activity
THEIN_RS02795	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
THEIN_RS02800	COG0137	argininosuccinate synthase activity
THEIN_RS02805	COG0142	geranyltranstransferase activity
THEIN_RS02825	COG4191	Histidine kinase
THEIN_RS02830	COG2195	Cleaves the N-terminal amino acid of tripeptides
THEIN_RS02835	COG1254	Belongs to the acylphosphatase family
THEIN_RS02845	COG1993	acr, cog1993
THEIN_RS02850	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
THEIN_RS02855	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
THEIN_RS02870	COG1619	proteins homologs of microcin C7 resistance protein MccF
THEIN_RS02890	COG4206	TonB-dependent receptor
THEIN_RS02905	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
THEIN_RS02905	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
THEIN_RS02925	COG0227	Belongs to the bacterial ribosomal protein bL28 family
THEIN_RS02930	COG0305	Participates in initiation and elongation during chromosome replication
THEIN_RS02940	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
THEIN_RS02945	COG0322	excinuclease ABC activity
THEIN_RS02960	COG0470	DNA polymerase III
THEIN_RS02965	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
THEIN_RS02970	COG2890	protein-(glutamine-N5) methyltransferase activity
THEIN_RS02980	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
THEIN_RS02995	COG0438	transferase activity, transferring glycosyl groups
THEIN_RS03005	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
THEIN_RS03010	COG0731	radical SAM domain protein
THEIN_RS03010	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
THEIN_RS03015	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
THEIN_RS03020	COG0668	transmembrane transport
THEIN_RS03025	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
THEIN_RS03030	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
THEIN_RS03030	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
THEIN_RS03040	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
THEIN_RS03045	COG1136	(ABC) transporter
THEIN_RS03055	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
THEIN_RS03060	COG0210	DNA helicase
THEIN_RS03075	COG0586	Pfam SNARE associated Golgi protein
THEIN_RS03085	COG1074	ATP-dependent DNA helicase activity
THEIN_RS03100	COG1030	water channel activity
THEIN_RS03105	COG0583	DNA-binding transcription factor activity
THEIN_RS03110	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
THEIN_RS03115	COG0460	homoserine dehydrogenase
THEIN_RS03120	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
THEIN_RS03140	COG0425	Belongs to the sulfur carrier protein TusA family
THEIN_RS03145	COG2391	methyltransferase activity
THEIN_RS03150	COG0612	Peptidase, M16
THEIN_RS03165	COG0489	protein tyrosine kinase activity
THEIN_RS03170	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
THEIN_RS03180	COG0706	membrane insertase activity
THEIN_RS03185	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
THEIN_RS03190	COG0594	ribonuclease P activity
THEIN_RS03200	COG0303	'Molybdopterin
THEIN_RS03240	COG0335	large ribosomal subunit rRNA binding
THEIN_RS03245	COG4752	Belongs to the RNA methyltransferase TrmD family
THEIN_RS03250	COG0336	Belongs to the RNA methyltransferase TrmD family
THEIN_RS03260	COG1968	undecaprenyl-diphosphatase activity
THEIN_RS03265	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
THEIN_RS03270	COG2264	protein methyltransferase activity
THEIN_RS03305	COG0138	bifunctional purine biosynthesis protein purh
THEIN_RS03310	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
THEIN_RS03315	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
THEIN_RS03335	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
THEIN_RS03370	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
THEIN_RS03375	COG0215	cysteine-tRNA ligase activity
THEIN_RS03380	COG2204	response regulator
THEIN_RS03385	COG4191	Histidine kinase
THEIN_RS03400	COG1653	transport
THEIN_RS03405	COG1175	transmembrane transport
THEIN_RS03415	COG0584	glycerophosphoryl diester phosphodiesterase
THEIN_RS03430	COG4974	Belongs to the 'phage' integrase family
THEIN_RS03435	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
THEIN_RS03440	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
THEIN_RS03445	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
THEIN_RS03450	COG1388	LysM domain
THEIN_RS03450	COG1376	ErfK ybiS ycfS ynhG family protein
THEIN_RS03490	COG1132	(ABC) transporter
THEIN_RS03505	COG0815	Transfers the fatty acyl group on membrane lipoproteins
THEIN_RS03530	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
THEIN_RS03540	COG1598	PFAM Uncharacterised protein family UPF0150
THEIN_RS03570	COG0297	glycogen (starch) synthase activity
THEIN_RS03575	COG0367	asparagine synthase
THEIN_RS03580	COG0438	transferase activity, transferring glycosyl groups
THEIN_RS03605	COG1555	photosystem II stabilization
THEIN_RS03700	COG2089	acid synthase
THEIN_RS03705	COG1083	cytidylyl-transferase
THEIN_RS03735	COG0217	transcriptional regulatory protein
THEIN_RS03740	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
THEIN_RS03745	COG0632	four-way junction helicase activity
THEIN_RS03750	COG2255	four-way junction helicase activity
THEIN_RS03755	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
THEIN_RS03770	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
THEIN_RS03775	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
THEIN_RS03780	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
THEIN_RS03785	COG3339	Conserved Protein
THEIN_RS03790	COG1260	myo-inositol-1-phosphate synthase
THEIN_RS03795	COG0436	Aminotransferase
THEIN_RS03810	COG0741	lytic transglycosylase activity
THEIN_RS03820	COG1469	GTP cyclohydrolase I activity
THEIN_RS03830	COG0442	prolyl-tRNA aminoacylation
THEIN_RS03835	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
THEIN_RS03840	COG0516	GMP reductase activity
THEIN_RS03840	COG0517	IMP dehydrogenase activity
THEIN_RS03845	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
THEIN_RS03860	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
THEIN_RS03870	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
THEIN_RS03880	COG0535	radical SAM domain protein
THEIN_RS03890	COG0215	cysteine-tRNA ligase activity
THEIN_RS03900	COG3956	TIGRFAM MazG family protein
THEIN_RS03910	COG0430	RNA-3'-phosphate cyclase activity
THEIN_RS03915	COG4608	Belongs to the ABC transporter superfamily
THEIN_RS03945	COG0444	Belongs to the ABC transporter superfamily
THEIN_RS03960	COG0668	transmembrane transport
THEIN_RS03965	COG1047	Peptidyl-prolyl cis-trans
THEIN_RS03975	COG1449	Belongs to the glycosyl hydrolase 57 family
THEIN_RS03990	COG1674	ftsk spoiiie
THEIN_RS04025	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
THEIN_RS04035	COG1332	CRISPR-associated RAMP protein, Csm5 family
THEIN_RS04065	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
THEIN_RS04065	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
THEIN_RS04075	COG0018	arginyl-trna synthetase
THEIN_RS04100	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
THEIN_RS04120	COG0133	tryptophan synthase activity
THEIN_RS04125	COG0159	tryptophan synthase activity
THEIN_RS04135	COG0343	queuine tRNA-ribosyltransferase activity
THEIN_RS04140	COG1862	Preprotein translocase
THEIN_RS04145	COG1492	cobalamin metabolic process
THEIN_RS04150	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
THEIN_RS04200	COG1294	oxidase, subunit
THEIN_RS04205	COG1271	oxidase subunit
THEIN_RS04210	COG1959	2 iron, 2 sulfur cluster binding
THEIN_RS04215	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
THEIN_RS04220	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
THEIN_RS04225	COG2045	Belongs to the ComB family
THEIN_RS04230	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
THEIN_RS04230	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
THEIN_RS04250	COG0504	CTP synthase activity
THEIN_RS04260	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
THEIN_RS04265	COG1937	Protein conserved in bacteria
THEIN_RS04275	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
THEIN_RS04275	COG0512	Glutamine amidotransferase of anthranilate synthase
THEIN_RS04285	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
THEIN_RS04295	COG1522	sequence-specific DNA binding
THEIN_RS04300	COG1566	PFAM secretion protein HlyD family protein
THEIN_RS04305	COG0477	Major facilitator Superfamily
THEIN_RS04315	COG2078	PFAM AMMECR1 domain protein
THEIN_RS04325	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
THEIN_RS04330	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
THEIN_RS04345	COG0820	rRNA (adenine-C2-)-methyltransferase activity
THEIN_RS04350	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
THEIN_RS04365	COG0740	serine-type endopeptidase activity
THEIN_RS04375	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
THEIN_RS04395	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
THEIN_RS04415	COG0181	hydroxymethylbilane synthase activity
THEIN_RS04435	COG1104	cysteine desulfurase activity
THEIN_RS04445	COG1611	Belongs to the LOG family
THEIN_RS04450	COG1381	Involved in DNA repair and RecF pathway recombination
THEIN_RS04460	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
THEIN_RS04475	COG0211	Belongs to the bacterial ribosomal protein bL27 family
THEIN_RS04480	COG0261	This protein binds to 23S rRNA in the presence of protein L20
THEIN_RS04500	COG1090	epimerase
THEIN_RS04505	COG4191	Histidine kinase
THEIN_RS04520	COG2920	part of a sulfur-relay system
THEIN_RS04530	COG0602	queuosine metabolic process
THEIN_RS04535	COG0720	synthase
THEIN_RS04550	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
THEIN_RS04570	COG0445	tRNA wobble uridine modification
THEIN_RS04580	COG1253	flavin adenine dinucleotide binding
THEIN_RS04585	COG1253	flavin adenine dinucleotide binding
THEIN_RS04590	COG0628	permease
THEIN_RS04595	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
THEIN_RS04600	COG0525	valine-tRNA ligase activity
THEIN_RS04610	COG1047	Peptidyl-prolyl cis-trans
THEIN_RS04615	COG3852	Histidine kinase
THEIN_RS04640	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
THEIN_RS04660	COG0067	glutamate synthase
THEIN_RS04670	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
THEIN_RS04675	COG4980	gas vesicle protein
THEIN_RS04700	COG1388	LysM domain
THEIN_RS04700	COG0741	lytic transglycosylase activity
THEIN_RS04710	COG1525	nuclease
THEIN_RS04715	COG1605	Chorismate mutase
THEIN_RS04715	COG0077	Prephenate dehydratase
THEIN_RS04735	COG0569	domain protein
THEIN_RS04740	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
THEIN_RS04745	COG0531	amino acid
THEIN_RS04750	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
THEIN_RS04765	COG0210	DNA helicase
THEIN_RS04790	COG0617	tRNA 3'-terminal CCA addition
THEIN_RS04810	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
THEIN_RS04815	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
THEIN_RS04815	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
THEIN_RS04820	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
THEIN_RS04825	COG0012	GTP binding
THEIN_RS04830	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
THEIN_RS04840	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
THEIN_RS04850	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
THEIN_RS04855	COG0456	acetyltransferase
THEIN_RS04855	COG0454	-acetyltransferase
THEIN_RS04865	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
THEIN_RS04870	COG1280	lysine exporter protein (LysE YggA)
THEIN_RS04880	COG2217	Heavy metal translocating P-type atpase
THEIN_RS04930	COG0543	2 iron, 2 sulfur cluster binding
THEIN_RS04935	COG0107	imidazoleglycerol-phosphate synthase activity
THEIN_RS04950	COG0511	ligase activity, forming carbon-carbon bonds
THEIN_RS04955	COG0439	Biotin carboxylase
THEIN_RS04960	COG5001	Diguanylate cyclase
THEIN_RS04975	COG1475	DNA binding
THEIN_RS04980	COG1192	Involved in chromosome partitioning
THEIN_RS04990	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
THEIN_RS04995	COG4608	Belongs to the ABC transporter superfamily
THEIN_RS05000	COG0444	Belongs to the ABC transporter superfamily
THEIN_RS05005	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
THEIN_RS05010	COG0601	transmembrane transport
THEIN_RS05015	COG0747	negative chemotaxis
THEIN_RS05020	COG0571	ribonuclease III activity
THEIN_RS05025	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
THEIN_RS05030	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
THEIN_RS05035	COG1546	Belongs to the CinA family
THEIN_RS05035	COG1058	Belongs to the CinA family
THEIN_RS05045	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
THEIN_RS05050	COG0540	Belongs to the ATCase OTCase family
THEIN_RS05055	COG1528	Iron-storage protein
THEIN_RS05060	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
THEIN_RS05065	COG1278	Cold shock
THEIN_RS05070	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
THEIN_RS05080	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
THEIN_RS05085	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
THEIN_RS05100	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
THEIN_RS05105	COG0592	DNA-directed DNA polymerase activity
THEIN_RS05110	COG0187	DNA topoisomerase II activity
THEIN_RS05135	COG0310	cobalt ion transport
THEIN_RS05150	COG1122	ATPase activity
THEIN_RS05160	COG0799	negative regulation of ribosome biogenesis
THEIN_RS05165	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
THEIN_RS05175	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
THEIN_RS05190	COG1151	hydroxylamine reductase activity
THEIN_RS05240	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
THEIN_RS05245	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
THEIN_RS05250	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
THEIN_RS05255	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
THEIN_RS05270	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
THEIN_RS05275	COG0312	modulator of DNA gyrase
THEIN_RS05280	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
THEIN_RS05285	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
THEIN_RS05290	COG0840	transmembrane signaling receptor activity
THEIN_RS05295	COG0285	dihydrofolate synthase activity
THEIN_RS05300	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
THEIN_RS05310	COG0860	N-Acetylmuramoyl-L-alanine amidase
THEIN_RS05315	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
THEIN_RS05320	COG1573	uracil-dna glycosylase
THEIN_RS05330	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
THEIN_RS05335	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
THEIN_RS05340	COG0347	Belongs to the P(II) protein family
THEIN_RS05345	COG0347	Belongs to the P(II) protein family
THEIN_RS05350	COG1433	Dinitrogenase iron-molybdenum cofactor
THEIN_RS05350	COG0535	radical SAM domain protein
THEIN_RS05365	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
THEIN_RS05380	COG0708	Exodeoxyribonuclease III
THEIN_RS05395	COG4191	Histidine kinase
THEIN_RS05400	COG0492	ferredoxin-NADP+ reductase activity
THEIN_RS05410	COG0613	PHP domain protein
THEIN_RS05415	COG1187	pseudouridine synthase activity
THEIN_RS05420	COG0196	riboflavin kinase activity
THEIN_RS05430	COG0505	Belongs to the CarA family
THEIN_RS05455	COG0232	Belongs to the dGTPase family. Type 2 subfamily
THEIN_RS05460	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
THEIN_RS05465	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
THEIN_RS05470	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
THEIN_RS05485	COG0559	Belongs to the binding-protein-dependent transport system permease family
THEIN_RS05495	COG0438	transferase activity, transferring glycosyl groups
THEIN_RS05525	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
THEIN_RS05530	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
THEIN_RS05540	COG0243	molybdopterin cofactor binding
THEIN_RS05555	COG0037	tRNA processing
THEIN_RS05570	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
THEIN_RS05580	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
THEIN_RS05610	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
THEIN_RS05615	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
THEIN_RS05640	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
THEIN_RS05645	COG1796	DNA polymerase
THEIN_RS05645	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
THEIN_RS05675	COG1335	isochorismatase
THEIN_RS05700	COG0134	indole-3-glycerol-phosphate synthase activity
THEIN_RS05710	COG0019	diaminopimelate decarboxylase activity
THEIN_RS05715	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
THEIN_RS05720	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
THEIN_RS05725	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
THEIN_RS05760	COG0668	transmembrane transport
THEIN_RS05765	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
THEIN_RS05780	COG0402	S-adenosylhomocysteine deaminase activity
THEIN_RS05785	COG0804	urea catabolic process
THEIN_RS05795	COG0831	urea catabolic process
THEIN_RS05840	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
THEIN_RS05865	COG3118	belongs to the thioredoxin family
THEIN_RS05870	COG3383	formate dehydrogenase (NAD+) activity
THEIN_RS05885	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
THEIN_RS05900	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
THEIN_RS05905	COG0411	ABC transporter
THEIN_RS05915	COG2204	response regulator
THEIN_RS05920	COG5000	phosphorelay sensor kinase activity
THEIN_RS05930	COG0778	Nitroreductase
THEIN_RS05930	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
THEIN_RS05955	COG3876	Protein conserved in bacteria
THEIN_RS05970	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
THEIN_RS05975	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
THEIN_RS06000	COG1127	ABC transporter
THEIN_RS06005	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
THEIN_RS06010	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
THEIN_RS06025	COG0671	phosphoesterase, PA-phosphatase related
THEIN_RS06055	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
THEIN_RS06080	COG1379	DNA repair
THEIN_RS06085	COG3852	Histidine kinase
THEIN_RS06090	COG0357	Ribosomal RNA small subunit methyltransferase G
THEIN_RS06095	COG0556	nucleotide-excision repair
THEIN_RS06100	COG0564	pseudouridine synthase activity
THEIN_RS06125	COG1420	regulation of RNA biosynthetic process
THEIN_RS06130	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
THEIN_RS06135	COG0443	Heat shock 70 kDa protein
THEIN_RS06140	COG0742	ribosomal rna small subunit methyltransferase
THEIN_RS06145	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
THEIN_RS06155	COG0235	Class ii aldolase
THEIN_RS06165	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
THEIN_RS06185	COG0151	Belongs to the GarS family
THEIN_RS06200	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
THEIN_RS06205	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
THEIN_RS06210	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
THEIN_RS06220	COG3409	Peptidoglycan-binding domain 1 protein
THEIN_RS06220	COG3267	Type II secretory pathway component ExeA
THEIN_RS06225	COG3206	protein involved in exopolysaccharide biosynthesis
THEIN_RS06225	COG0489	protein tyrosine kinase activity
THEIN_RS06245	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
THEIN_RS06255	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
THEIN_RS06260	COG3118	belongs to the thioredoxin family
THEIN_RS06260	COG0492	ferredoxin-NADP+ reductase activity
THEIN_RS06265	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
THEIN_RS06275	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
THEIN_RS06280	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
THEIN_RS06285	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
THEIN_RS06300	COG1476	TRANSCRIPTIONal
THEIN_RS06315	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
THEIN_RS06320	COG0228	four-way junction DNA binding
THEIN_RS06325	COG1837	Belongs to the UPF0109 family
THEIN_RS06330	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
THEIN_RS06335	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
THEIN_RS06340	COG0719	Fe-S assembly protein
THEIN_RS06350	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
THEIN_RS06355	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
THEIN_RS06380	COG2204	response regulator
THEIN_RS06405	COG0218	Necessary for normal cell division and for the maintenance of normal septation
THEIN_RS06425	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
THEIN_RS06450	COG1418	mRNA catabolic process
THEIN_RS06455	COG1692	metallophosphoesterase
THEIN_RS06460	COG0735	belongs to the Fur family
THEIN_RS06510	COG0297	glycogen (starch) synthase activity
THEIN_RS06515	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
THEIN_RS06525	COG0606	chelatase, subunit chli
THEIN_RS06530	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
THEIN_RS06540	COG0585	pseudouridine synthase activity
THEIN_RS06545	COG0653	protein targeting
THEIN_RS06555	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
THEIN_RS06570	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
THEIN_RS06575	COG0581	inorganic phosphate transmembrane transporter activity
THEIN_RS06580	COG0573	inorganic phosphate transmembrane transporter activity
THEIN_RS06600	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
THEIN_RS06605	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
THEIN_RS06610	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
THEIN_RS06615	COG0165	Argininosuccinate lyase
THEIN_RS06620	COG0124	histidyl-tRNA synthetase
THEIN_RS06645	COG0356	it plays a direct role in the translocation of protons across the membrane
THEIN_RS06650	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
THEIN_RS06670	COG0859	PFAM glycosyl transferase family 9
THEIN_RS06675	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
THEIN_RS06680	COG0859	PFAM glycosyl transferase family 9
THEIN_RS06685	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
THEIN_RS06690	COG0557	exoribonuclease II activity
THEIN_RS06695	COG3706	GGDEF domain
THEIN_RS06705	COG0483	inositol monophosphate 1-phosphatase activity
THEIN_RS06710	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
THEIN_RS06715	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
THEIN_RS06720	COG2703	oxygen carrier activity
THEIN_RS06725	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
THEIN_RS06730	COG1355	regulation of microtubule-based process
THEIN_RS06735	COG1077	Cell shape determining protein MreB Mrl
THEIN_RS06750	COG0768	penicillin binding
THEIN_RS06755	COG0772	Belongs to the SEDS family
THEIN_RS06770	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
THEIN_RS06775	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
THEIN_RS06780	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
THEIN_RS06785	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
THEIN_RS06790	COG0355	proton-transporting ATP synthase activity, rotational mechanism
THEIN_RS06800	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
THEIN_RS06875	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
THEIN_RS06885	COG1606	tRNA processing
THEIN_RS06895	COG0516	GMP reductase activity
THEIN_RS06895	COG0517	IMP dehydrogenase activity
THEIN_RS06920	COG2226	methyltransferase
THEIN_RS06945	COG0563	adenylate kinase activity
THEIN_RS06950	COG0552	protein localization to endoplasmic reticulum
THEIN_RS06955	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
THEIN_RS06970	COG1131	(ABC) transporter
THEIN_RS06980	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
THEIN_RS06985	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
THEIN_RS06995	COG0101	tRNA pseudouridine synthase activity
THEIN_RS07005	COG4771	TonB-dependent receptor
THEIN_RS07020	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
THEIN_RS07025	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
THEIN_RS07035	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
THEIN_RS07040	COG0459	protein refolding
THEIN_RS07050	COG4783	chaperone-mediated protein folding
THEIN_RS07055	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
THEIN_RS07060	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
THEIN_RS07075	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
THEIN_RS07090	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
THEIN_RS07100	COG2877	3-deoxy-8-phosphooctulonate synthase activity
THEIN_RS07115	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
THEIN_RS07125	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
THEIN_RS07135	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
THEIN_RS07140	COG1660	Displays ATPase and GTPase activities
THEIN_RS07150	COG0456	acetyltransferase
THEIN_RS07160	COG0574	Belongs to the PEP-utilizing enzyme family
THEIN_RS07160	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
THEIN_RS07165	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
THEIN_RS07170	COG0126	phosphoglycerate kinase activity
THEIN_RS07175	COG0149	triose-phosphate isomerase activity
THEIN_RS07185	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
THEIN_RS07190	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
THEIN_RS07215	COG0674	pyruvate-flavodoxin oxidoreductase activity
THEIN_RS07220	COG1013	pyruvate-flavodoxin oxidoreductase activity
THEIN_RS07230	COG1151	hydroxylamine reductase activity
THEIN_RS07245	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
THEIN_RS07255	COG1793	dna ligase
THEIN_RS07260	COG0039	L-malate dehydrogenase activity
THEIN_RS07290	COG0640	Transcriptional regulator
THEIN_RS07305	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
THEIN_RS07370	COG0709	Synthesizes selenophosphate from selenide and ATP
THEIN_RS07390	COG1110	DNA topoisomerase II activity
THEIN_RS07405	COG0752	glycyl-tRNA synthetase alpha subunit
THEIN_RS07410	COG0751	glycine-tRNA ligase activity
THEIN_RS07425	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
THEIN_RS07430	COG0049	tRNA binding
THEIN_RS07435	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
THEIN_RS07440	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
THEIN_RS07445	COG0051	transcription antitermination factor activity, RNA binding
THEIN_RS07450	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
THEIN_RS07460	COG0089	rRNA binding
THEIN_RS07465	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
THEIN_RS07470	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
THEIN_RS07475	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
THEIN_RS07480	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
THEIN_RS07485	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
THEIN_RS07490	COG0255	Belongs to the universal ribosomal protein uL29 family
THEIN_RS07495	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
THEIN_RS07500	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
THEIN_RS07505	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
THEIN_RS07510	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
THEIN_RS07515	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
THEIN_RS07520	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
THEIN_RS07525	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
THEIN_RS07530	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
THEIN_RS07535	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
THEIN_RS07540	COG1841	ribosomal large subunit assembly
THEIN_RS07545	COG0200	Binds to the 23S rRNA
THEIN_RS07550	COG0201	protein transport
THEIN_RS07555	COG0563	adenylate kinase activity
THEIN_RS07565	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
THEIN_RS07570	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
THEIN_RS07575	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
THEIN_RS07580	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
THEIN_RS07585	COG0202	RNA polymerase activity
THEIN_RS07590	COG0203	ribosomal protein L17
THEIN_RS07595	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
THEIN_RS07600	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
THEIN_RS07605	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
THEIN_RS07615	COG0004	ammonium transporteR
THEIN_RS07660	COG1061	Type III restriction enzyme res subunit
THEIN_RS07710	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
THEIN_RS07715	COG0497	DNA recombination
THEIN_RS07720	COG0301	tRNA thio-modification
THEIN_RS07725	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
THEIN_RS07735	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
THEIN_RS07745	COG0673	inositol 2-dehydrogenase activity
THEIN_RS07750	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
THEIN_RS07760	COG0438	transferase activity, transferring glycosyl groups
THEIN_RS07770	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
THEIN_RS07775	COG0521	Mo-molybdopterin cofactor biosynthetic process
THEIN_RS07780	COG0589	response to stress
THEIN_RS07790	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
THEIN_RS07795	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
THEIN_RS07800	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
THEIN_RS07805	COG0193	aminoacyl-tRNA hydrolase activity
THEIN_RS07810	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
THEIN_RS07815	COG0484	heat shock protein binding
THEIN_RS07820	COG1570	exodeoxyribonuclease VII activity
THEIN_RS07830	COG0739	heme binding
THEIN_RS07840	COG0142	geranyltranstransferase activity
THEIN_RS07850	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
THEIN_RS07875	COG0284	orotidine-5'-phosphate decarboxylase activity
THEIN_RS07915	COG1797	cobyrinic acid a,c-diamide synthase activity
THEIN_RS07935	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
THEIN_RS07945	COG4122	O-methyltransferase activity
THEIN_RS07950	COG1362	aminopeptidase activity
THEIN_RS07975	COG0519	Catalyzes the synthesis of GMP from XMP
THEIN_RS07980	COG1592	Rubrerythrin
THEIN_RS08000	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
THEIN_RS08015	COG0732	type I restriction modification DNA specificity domain
THEIN_RS08020	COG1404	Belongs to the peptidase S8 family
THEIN_RS08025	COG0464	growth
THEIN_RS08030	COG4804	nuclease activity
THEIN_RS08035	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
THEIN_RS08070	COG2199	diguanylate cyclase activity
THEIN_RS08070	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
THEIN_RS08080	COG0758	DNA mediated transformation
THEIN_RS08085	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
THEIN_RS08095	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
THEIN_RS08100	COG1333	cytochrome c biogenesis protein
THEIN_RS08110	COG1598	PFAM Uncharacterised protein family UPF0150
THEIN_RS08120	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
THEIN_RS08125	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
THEIN_RS08130	COG0291	Belongs to the bacterial ribosomal protein bL35 family
THEIN_RS08135	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
THEIN_RS08140	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
THEIN_RS08145	COG0072	phenylalanine-tRNA ligase activity
THEIN_RS08150	COG0776	regulation of translation
THEIN_RS08165	COG0438	transferase activity, transferring glycosyl groups
THEIN_RS08170	COG0438	transferase activity, transferring glycosyl groups
THEIN_RS08200	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
THEIN_RS08215	COG1242	4 iron, 4 sulfur cluster binding
THEIN_RS08230	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
THEIN_RS08235	COG1615	UPF0182 protein
THEIN_RS08245	COG3852	Histidine kinase
THEIN_RS08250	COG2204	response regulator
THEIN_RS08265	COG0243	molybdopterin cofactor binding
THEIN_RS08270	COG0437	4 iron, 4 sulfur cluster binding
THEIN_RS08275	COG0437	4 iron, 4 sulfur cluster binding
THEIN_RS08280	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
THEIN_RS08290	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
THEIN_RS08295	COG0649	NAD binding
THEIN_RS08305	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
THEIN_RS08310	COG0839	Belongs to the complex I subunit 6 family
THEIN_RS08315	COG0713	ATP synthesis coupled electron transport
THEIN_RS08320	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
THEIN_RS08335	COG0318	PFAM AMP-dependent synthetase and ligase
THEIN_RS08345	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
THEIN_RS08355	COG1490	D-aminoacyl-tRNA deacylase activity
THEIN_RS08365	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
THEIN_RS08370	COG1185	polyribonucleotide nucleotidyltransferase activity
THEIN_RS08390	COG3842	ATPase activity
THEIN_RS08395	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
THEIN_RS08415	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
THEIN_RS08420	COG1131	(ABC) transporter
THEIN_RS08440	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
THEIN_RS08450	COG0444	Belongs to the ABC transporter superfamily
THEIN_RS08455	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
THEIN_RS08460	COG0601	transmembrane transport
THEIN_RS08465	COG0747	negative chemotaxis
THEIN_RS08495	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
THEIN_RS08510	COG0745	RESPONSE REGULATOR receiver
THEIN_RS08515	COG0529	Catalyzes the synthesis of activated sulfate
THEIN_RS08520	COG0438	transferase activity, transferring glycosyl groups
THEIN_RS08535	COG2264	protein methyltransferase activity
THEIN_RS08540	COG1385	rRNA (uridine-N3-)-methyltransferase activity
THEIN_RS08545	COG0501	Belongs to the peptidase M48B family
THEIN_RS08560	COG1489	DNA binding
THEIN_RS08570	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
THEIN_RS08575	COG0113	porphobilinogen synthase activity
THEIN_RS08585	COG0432	Pfam Uncharacterised protein family UPF0047
THEIN_RS08590	COG0629	single-stranded DNA binding
THEIN_RS08595	COG1196	nuclear chromosome segregation
THEIN_RS08600	COG0359	binds to the 23S rRNA
THEIN_RS08605	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
THEIN_RS08610	COG0360	Binds together with S18 to 16S ribosomal RNA
THEIN_RS08620	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
THEIN_RS08625	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
THEIN_RS08630	COG3901	Regulator of nitric oxide reductase transcription
THEIN_RS08630	COG0348	domain, Protein
THEIN_RS08640	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
THEIN_RS08645	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
THEIN_RS08660	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
THEIN_RS08665	COG1566	PFAM secretion protein HlyD family protein
THEIN_RS08665	COG1418	mRNA catabolic process
THEIN_RS08675	COG1530	ribonuclease E activity
THEIN_RS08710	COG1538	Outer membrane efflux protein
THEIN_RS08730	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
THEIN_RS08740	COG0635	Involved in the biosynthesis of porphyrin-containing compound
THEIN_RS08750	COG1418	mRNA catabolic process
THEIN_RS08755	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
THEIN_RS08755	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
THEIN_RS08765	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
THEIN_RS08770	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
THEIN_RS08775	COG0416	fatty acid biosynthetic process
THEIN_RS08810	COG1832	CoA-binding protein
THEIN_RS08845	COG0367	asparagine synthase
THEIN_RS08850	COG0109	protoheme IX farnesyltransferase activity
THEIN_RS08910	COG0297	glycogen (starch) synthase activity
THEIN_RS08915	COG0463	Glycosyl transferase, family 2
THEIN_RS08925	COG0673	inositol 2-dehydrogenase activity
THEIN_RS08975	COG1785	Belongs to the alkaline phosphatase family
THEIN_RS08995	COG0617	tRNA 3'-terminal CCA addition
THEIN_RS09015	COG1702	phosphate starvation-inducible protein PhoH
THEIN_RS09035	COG1872	DUF167
THEIN_RS09040	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
THEIN_RS09045	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
THEIN_RS09045	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
THEIN_RS09085	COG3259	Nickel-dependent hydrogenase
THEIN_RS09090	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
THEIN_RS09180	COG1635	Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur
THEIN_RS09185	COG0157	Belongs to the NadC ModD family
THEIN_RS09190	COG2204	response regulator
THEIN_RS09200	COG2204	response regulator
THEIN_RS09210	COG1558	bacterial-type flagellum-dependent cell motility
THEIN_RS09215	COG1677	Flagellar hook-basal body complex protein FliE
THEIN_RS09220	COG1766	The M ring may be actively involved in energy transduction
THEIN_RS09225	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
THEIN_RS09235	COG1157	protein secretion by the type III secretion system
THEIN_RS09260	COG0437	4 iron, 4 sulfur cluster binding
THEIN_RS09265	COG3383	formate dehydrogenase (NAD+) activity
THEIN_RS09270	COG3383	formate dehydrogenase (NAD+) activity
THEIN_RS09270	COG0243	molybdopterin cofactor binding
THEIN_RS09300	COG0495	leucyl-tRNA aminoacylation
THEIN_RS09305	COG0538	isocitrate dehydrogenase activity
THEIN_RS09320	COG2204	response regulator
THEIN_RS09345	COG0802	atpase or kinase
THEIN_RS09350	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
THEIN_RS09350	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
THEIN_RS09355	COG0037	tRNA processing
THEIN_RS09370	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
THEIN_RS09375	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
THEIN_RS09385	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
THEIN_RS09390	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
THEIN_RS09390	COG1773	rubredoxin
THEIN_RS09410	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
THEIN_RS09415	COG2226	methyltransferase
THEIN_RS09425	COG1329	Transcriptional regulator
THEIN_RS09430	COG4956	integral membrane protein (PIN domain superfamily)
THEIN_RS09435	COG0303	'Molybdopterin
THEIN_RS09440	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
THEIN_RS09445	COG0066	3-isopropylmalate dehydratase activity
THEIN_RS09470	COG3842	ATPase activity
THEIN_RS09490	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
THEIN_RS09495	COG1108	ABC-type Mn2 Zn2 transport systems permease components
THEIN_RS09500	COG1121	(ABC) transporter
THEIN_RS09510	COG0494	nUDIX hydrolase
THEIN_RS09515	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
THEIN_RS09520	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
THEIN_RS09525	COG0564	pseudouridine synthase activity
THEIN_RS09555	COG0010	Belongs to the arginase family
THEIN_RS09570	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
THEIN_RS09570	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
THEIN_RS09575	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
THEIN_RS09580	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
THEIN_RS09610	COG3409	Peptidoglycan-binding domain 1 protein
THEIN_RS09610	COG3267	Type II secretory pathway component ExeA
THEIN_RS09620	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
THEIN_RS09625	COG2165	general secretion pathway protein
THEIN_RS09635	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
THEIN_RS09640	COG2252	PERMEase
THEIN_RS09650	COG1980	fructose-bisphosphate aldolase activity
THEIN_RS09670	COG1797	cobyrinic acid a,c-diamide synthase activity
THEIN_RS09690	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
THEIN_RS09695	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
THEIN_RS09725	COG0123	including yeast histone deacetylase and acetoin utilization protein
THEIN_RS09730	COG2095	MarC family integral membrane protein
THEIN_RS09735	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
THEIN_RS09735	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
THEIN_RS09740	COG2003	Belongs to the UPF0758 family
THEIN_RS09745	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
THEIN_RS09765	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
THEIN_RS09775	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
THEIN_RS09780	COG1322	Protein conserved in bacteria
THEIN_RS09790	COG0028	Belongs to the TPP enzyme family
THEIN_RS09795	COG0440	acetolactate synthase activity
THEIN_RS09800	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
THEIN_RS09805	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
THEIN_RS09810	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
THEIN_RS09815	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
THEIN_RS09960	COG0629	single-stranded DNA binding
THEIN_RS10115	COG4974	Belongs to the 'phage' integrase family
THEIN_RS10120	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
THEIN_RS10125	COG0569	domain protein
THEIN_RS10130	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
THEIN_RS10140	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
THEIN_RS10140	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
THEIN_RS10145	COG1160	GTP binding
THEIN_RS10150	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
THEIN_RS10155	COG0439	Biotin carboxylase
THEIN_RS10160	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
THEIN_RS10185	COG0848	biopolymer transport protein
THEIN_RS10190	COG0811	peptide transport
THEIN_RS10220	COG1122	ATPase activity
THEIN_RS10250	COG4206	TonB-dependent receptor
THEIN_RS10265	COG0409	Hydrogenase expression formation protein
THEIN_RS10280	COG0268	Binds directly to 16S ribosomal RNA
THEIN_RS10290	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
THEIN_RS10295	COG1056	cytidyltransferase-related domain
THEIN_RS10295	COG1051	belongs to the nudix hydrolase family
THEIN_RS10305	COG0352	thiamine-phosphate diphosphorylase activity
THEIN_RS10315	COG1042	CoA-binding domain protein
THEIN_RS10315	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
THEIN_RS10315	COG0045	succinate-CoA ligase (ADP-forming) activity
THEIN_RS10320	COG0123	including yeast histone deacetylase and acetoin utilization protein
THEIN_RS10340	COG0247	lactate metabolic process
THEIN_RS10345	COG0277	FAD linked oxidase domain protein
THEIN_RS10350	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
THEIN_RS10360	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
THEIN_RS10365	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
THEIN_RS10370	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
THEIN_RS10370	COG1773	rubredoxin
THEIN_RS10375	COG0587	DNA-directed DNA polymerase activity
THEIN_RS10395	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
THEIN_RS10405	COG4974	Belongs to the 'phage' integrase family
THEIN_RS10410	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
THEIN_RS10410	COG0617	tRNA 3'-terminal CCA addition
THEIN_RS10410	COG3620	sequence-specific DNA binding
THEIN_RS10415	COG1994	Peptidase M50
THEIN_RS10430	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
THEIN_RS10455	COG0668	transmembrane transport
THEIN_RS10465	COG0047	phosphoribosylformylglycinamidine synthase activity
THEIN_RS10470	COG0805	protein transport
THEIN_RS10475	COG0405	Gamma-glutamyltransferase
THEIN_RS10480	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
THEIN_RS10485	COG1473	amidohydrolase
THEIN_RS10490	COG2033	superoxide reductase activity
THEIN_RS10495	COG0426	domain, Protein
THEIN_RS10505	COG1509	lysine 2,3-aminomutase activity
THEIN_RS10515	COG1458	PINc domain ribonuclease
THEIN_RS10520	COG0840	transmembrane signaling receptor activity
THEIN_RS10525	COG2204	response regulator
THEIN_RS10535	COG2204	response regulator
THEIN_RS10550	COG0730	response to heat
THEIN_RS10560	COG1233	COG1233 Phytoene dehydrogenase and related
THEIN_RS10580	COG0543	2 iron, 2 sulfur cluster binding
THEIN_RS10610	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
THEIN_RS10630	COG0110	maltose O-acetyltransferase activity
THEIN_RS10645	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
THEIN_RS10660	COG0750	zinc metalloprotease
THEIN_RS10680	COG0233	cytoplasmic translational termination
THEIN_RS10685	COG0528	UMP kinase activity
THEIN_RS10690	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
THEIN_RS10695	COG0052	Belongs to the universal ribosomal protein uS2 family
THEIN_RS10720	COG0542	response to heat
THEIN_RS10730	COG4106	trans-aconitate 2-methyltransferase activity
THEIN_RS10745	COG0180	Tryptophanyl-tRNA synthetase
THEIN_RS10770	COG2414	aldehyde ferredoxin oxidoreductase
THEIN_RS10805	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
THEIN_RS10810	COG1216	Glycosyl transferase, family 2
THEIN_RS10820	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
THEIN_RS10820	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
THEIN_RS10825	COG1774	PSP1 C-terminal conserved region
THEIN_RS10830	COG0135	phosphoribosylanthranilate isomerase activity
THEIN_RS10835	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
THEIN_RS10840	COG2165	general secretion pathway protein
THEIN_RS10880	COG1450	Type ii and iii secretion system protein
THEIN_RS10895	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
THEIN_RS10905	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
THEIN_RS10915	COG1210	Utp--glucose-1-phosphate uridylyltransferase
THEIN_RS10935	COG2884	Cell division ATP-binding protein ftsE
THEIN_RS10945	COG4942	peptidase
THEIN_RS10950	COG0793	Belongs to the peptidase S41A family
THEIN_RS10955	COG2861	carbohydrate metabolic process
THEIN_RS10960	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
THEIN_RS10965	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
THEIN_RS10970	COG0463	Glycosyl transferase, family 2
THEIN_RS10985	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
THEIN_RS10990	COG0446	pyridine nucleotide-disulphide oxidoreductase
THEIN_RS10995	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
THEIN_RS11000	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
THEIN_RS11010	COG1176	ABC-type spermidine putrescine transport system, permease component I
THEIN_RS11020	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
THEIN_RS11030	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
THEIN_RS11055	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
THEIN_RS11055	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
THEIN_RS11060	COG0776	regulation of translation
THEIN_RS11065	COG0148	phosphopyruvate hydratase activity
THEIN_RS11075	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
THEIN_RS11080	COG1773	rubredoxin
THEIN_RS11100	COG3383	formate dehydrogenase (NAD+) activity
THEIN_RS11105	COG0493	'glutamate synthase
THEIN_RS11165	COG0493	'glutamate synthase
THEIN_RS11170	COG1233	COG1233 Phytoene dehydrogenase and related
THEIN_RS11175	COG1151	hydroxylamine reductase activity
THEIN_RS11180	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
THEIN_RS11185	COG2759	Belongs to the formate--tetrahydrofolate ligase family
THEIN_RS11205	COG0174	glutamine synthetase
THEIN_RS11210	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
THEIN_RS11215	COG0347	Belongs to the P(II) protein family
THEIN_RS11225	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
THEIN_RS11230	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
THEIN_RS11235	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
THEIN_RS11260	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
THEIN_RS11265	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
THEIN_RS11275	COG1605	Chorismate mutase
THEIN_RS11275	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
THEIN_RS11280	COG2095	MarC family integral membrane protein
THEIN_RS11285	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
THEIN_RS11295	COG0436	Aminotransferase
THEIN_RS11305	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
THEIN_RS11315	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
THEIN_RS11330	COG5002	protein histidine kinase activity
THEIN_RS11355	COG0243	molybdopterin cofactor binding
THEIN_RS11365	COG1918	ferrous iron import across plasma membrane
THEIN_RS11365	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
THEIN_RS11380	COG0864	Transcriptional regulator
THEIN_RS11415	COG1758	RNA polymerase activity
THEIN_RS11425	COG1309	transcriptional regulator
THEIN_RS11455	COG0471	metal ion transport
THEIN_RS11460	COG3852	Histidine kinase
THEIN_RS11480	COG5002	protein histidine kinase activity
THEIN_RS11530	COG0357	Ribosomal RNA small subunit methyltransferase G
THEIN_RS11540	COG2703	oxygen carrier activity
THEIN_RS11555	COG1040	competence protein
THEIN_RS11560	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
THEIN_RS11565	COG0402	S-adenosylhomocysteine deaminase activity
THEIN_RS11575	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
THEIN_RS11580	COG1193	negative regulation of DNA recombination
THEIN_RS11600	COG3383	formate dehydrogenase (NAD+) activity
THEIN_RS11610	COG0243	molybdopterin cofactor binding
THEIN_RS11630	COG0704	Plays a role in the regulation of phosphate uptake
THEIN_RS11665	COG5002	protein histidine kinase activity
THEIN_RS11665	COG2198	Histidine kinase
THEIN_RS11665	COG0784	Response regulator, receiver
THEIN_RS11670	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
THEIN_RS11715	COG2264	protein methyltransferase activity
THEIN_RS11720	COG0725	ABC transporter, periplasmic molybdate-binding protein
THEIN_RS11725	COG0739	heme binding
THEIN_RS11730	COG1663	tetraacyldisaccharide 4'-kinase activity
THEIN_RS11735	COG1399	metal-binding, possibly nucleic acid-binding protein
THEIN_RS11740	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
THEIN_RS11765	COG0590	tRNA wobble adenosine to inosine editing
THEIN_RS11805	COG1543	Belongs to the glycosyl hydrolase 57 family
THEIN_RS11825	COG4191	Histidine kinase
THEIN_RS11835	COG0737	Belongs to the 5'-nucleotidase family
THEIN_RS11840	COG0575	Belongs to the CDS family
THEIN_RS11855	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import