locus-tag	class	description
HL41_RS00005	COG3259	Nickel-dependent hydrogenase
HL41_RS00040	COG0306	phosphate transporter
HL41_RS00070	COG0606	chelatase, subunit chli
HL41_RS00075	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HL41_RS00080	COG0356	it plays a direct role in the translocation of protons across the membrane
HL41_RS00100	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HL41_RS00115	COG1959	2 iron, 2 sulfur cluster binding
HL41_RS00140	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
HL41_RS00145	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HL41_RS00160	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HL41_RS00165	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HL41_RS00170	COG0698	ribose 5-phosphate isomerase
HL41_RS00175	COG0736	holo-[acyl-carrier-protein] synthase activity
HL41_RS00180	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HL41_RS00180	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HL41_RS00195	COG5000	phosphorelay sensor kinase activity
HL41_RS00205	COG1522	sequence-specific DNA binding
HL41_RS00210	COG0811	peptide transport
HL41_RS00215	COG0848	biopolymer transport protein
HL41_RS00230	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HL41_RS00235	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HL41_RS00235	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HL41_RS00240	COG0728	peptidoglycan biosynthetic process
HL41_RS00265	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
HL41_RS00270	COG0613	PHP domain protein
HL41_RS00275	COG0504	CTP synthase activity
HL41_RS00300	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HL41_RS00305	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HL41_RS00310	COG1892	Catalyzes the irreversible beta-carboxylation of phosphoenolpyruvate (PEP) to form oxaloacetate (OAA), a four- carbon dicarboxylic acid source for the tricarboxylic acid cycle
HL41_RS00320	COG1278	Cold shock
HL41_RS00330	COG3290	protein histidine kinase activity
HL41_RS00335	COG4974	Belongs to the 'phage' integrase family
HL41_RS00345	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
HL41_RS00350	COG0693	protein deglycase activity
HL41_RS00365	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HL41_RS00380	COG3706	GGDEF domain
HL41_RS00385	COG2835	tetraacyldisaccharide 4'-kinase activity
HL41_RS00395	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HL41_RS00400	COG1774	PSP1 C-terminal conserved region
HL41_RS00405	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HL41_RS00405	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HL41_RS00410	COG0537	adenosine 5'-monophosphoramidase activity
HL41_RS00415	COG0511	ligase activity, forming carbon-carbon bonds
HL41_RS00420	COG0439	Biotin carboxylase
HL41_RS00425	COG4752	Belongs to the RNA methyltransferase TrmD family
HL41_RS00425	COG0336	Belongs to the RNA methyltransferase TrmD family
HL41_RS00430	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HL41_RS00435	COG1837	Belongs to the UPF0109 family
HL41_RS00445	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HL41_RS00450	COG3108	Peptidase M15
HL41_RS00455	COG2989	Protein conserved in bacteria
HL41_RS00460	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HL41_RS00465	COG0235	Class ii aldolase
HL41_RS00470	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HL41_RS00475	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HL41_RS00480	COG0019	diaminopimelate decarboxylase activity
HL41_RS00510	COG1815	bacterial-type flagellum-dependent cell motility
HL41_RS00520	COG1677	Flagellar hook-basal body complex protein FliE
HL41_RS00525	COG1766	The M ring may be actively involved in energy transduction
HL41_RS00530	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HL41_RS00540	COG1157	protein secretion by the type III secretion system
HL41_RS00560	COG0735	belongs to the Fur family
HL41_RS00570	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
HL41_RS00575	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
HL41_RS00585	COG0165	Argininosuccinate lyase
HL41_RS00605	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HL41_RS00625	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
HL41_RS00630	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HL41_RS00640	COG0009	L-threonylcarbamoyladenylate synthase
HL41_RS00660	COG0805	protein transport
HL41_RS00665	COG0047	phosphoribosylformylglycinamidine synthase activity
HL41_RS00700	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HL41_RS00705	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HL41_RS00710	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
HL41_RS00715	COG0193	aminoacyl-tRNA hydrolase activity
HL41_RS00725	COG0519	Catalyzes the synthesis of GMP from XMP
HL41_RS00740	COG0333	Belongs to the bacterial ribosomal protein bL32 family
HL41_RS00745	COG0416	fatty acid biosynthetic process
HL41_RS00750	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HL41_RS00795	COG1362	aminopeptidase activity
HL41_RS00805	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
HL41_RS00830	COG0751	glycine-tRNA ligase activity
HL41_RS00835	COG0752	glycyl-tRNA synthetase alpha subunit
HL41_RS00840	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HL41_RS00850	COG1054	Belongs to the UPF0176 family
HL41_RS00855	COG0668	transmembrane transport
HL41_RS00865	COG0688	phosphatidylethanolamine metabolic process
HL41_RS00870	COG1183	phosphatidylcholine synthase activity
HL41_RS00875	COG2052	Domain of unknown function (DUF370)
HL41_RS00880	COG0194	GDP metabolic process
HL41_RS00885	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HL41_RS00905	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HL41_RS00915	COG1136	(ABC) transporter
HL41_RS00920	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HL41_RS00925	COG4786	Flagellar basal body rod
HL41_RS00940	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
HL41_RS00945	COG1706	bacterial-type flagellum-dependent cell motility
HL41_RS00960	COG4786	Flagellar basal body rod
HL41_RS00960	COG1256	bacterial-type flagellum assembly
HL41_RS00970	COG0823	Involved in the tonB-independent uptake of proteins
HL41_RS00975	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HL41_RS00980	COG0436	Aminotransferase
HL41_RS00995	COG1234	tRNA 3'-trailer cleavage
HL41_RS01030	COG0772	Belongs to the SEDS family
HL41_RS01045	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HL41_RS01050	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HL41_RS01055	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HL41_RS01060	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HL41_RS01065	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HL41_RS01070	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HL41_RS01075	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HL41_RS01090	COG1160	GTP binding
HL41_RS01110	COG1227	inorganic diphosphatase activity
HL41_RS01115	COG0157	Belongs to the NadC ModD family
HL41_RS01120	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HL41_RS01125	COG0443	Heat shock 70 kDa protein
HL41_RS01130	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
HL41_RS01140	COG0564	pseudouridine synthase activity
HL41_RS01150	COG0018	arginyl-trna synthetase
HL41_RS01160	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
HL41_RS01165	COG2920	part of a sulfur-relay system
HL41_RS01175	COG1960	acyl-CoA dehydrogenase activity
HL41_RS01180	COG2086	electron transfer activity
HL41_RS01185	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
HL41_RS01195	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HL41_RS01200	COG0084	hydrolase, TatD family'
HL41_RS01210	COG1121	(ABC) transporter
HL41_RS01215	COG3956	TIGRFAM MazG family protein
HL41_RS01220	COG0066	3-isopropylmalate dehydratase activity
HL41_RS01225	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HL41_RS01230	COG1570	exodeoxyribonuclease VII activity
HL41_RS01235	COG1722	exodeoxyribonuclease VII activity
HL41_RS01245	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HL41_RS01260	COG0151	Belongs to the GarS family
HL41_RS01265	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HL41_RS01280	COG0731	radical SAM domain protein
HL41_RS01280	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HL41_RS01285	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HL41_RS01295	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HL41_RS01300	COG0052	Belongs to the universal ribosomal protein uS2 family
HL41_RS01305	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HL41_RS01310	COG0528	UMP kinase activity
HL41_RS01315	COG0233	cytoplasmic translational termination
HL41_RS01320	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HL41_RS01335	COG1181	Belongs to the D-alanine--D-alanine ligase family
HL41_RS01350	COG1242	4 iron, 4 sulfur cluster binding
HL41_RS01355	COG0579	oxidoreductase
HL41_RS01360	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HL41_RS01365	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HL41_RS01370	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HL41_RS01380	COG0758	DNA mediated transformation
HL41_RS01395	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HL41_RS01405	COG0335	large ribosomal subunit rRNA binding
HL41_RS01410	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HL41_RS01415	COG0792	nuclease activity
HL41_RS01430	COG0460	homoserine dehydrogenase
HL41_RS01440	COG3599	regulation of cell shape
HL41_RS01440	COG1418	mRNA catabolic process
HL41_RS01480	COG1418	mRNA catabolic process
HL41_RS01485	COG1692	metallophosphoesterase
HL41_RS01490	COG0242	peptide deformylase activity
HL41_RS01495	COG0857	belongs to the CobB CobQ family
HL41_RS01500	COG0402	S-adenosylhomocysteine deaminase activity
HL41_RS01515	COG1979	alcohol dehydrogenase
HL41_RS01520	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HL41_RS01525	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HL41_RS01530	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HL41_RS01535	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HL41_RS01540	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HL41_RS01545	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
HL41_RS01560	COG0037	tRNA processing
HL41_RS01600	COG1797	cobyrinic acid a,c-diamide synthase activity
HL41_RS01610	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HL41_RS01620	COG2703	oxygen carrier activity
HL41_RS01630	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
HL41_RS01665	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
HL41_RS01675	COG0343	queuine tRNA-ribosyltransferase activity
HL41_RS01680	COG0436	Aminotransferase
HL41_RS01695	COG1309	transcriptional regulator
HL41_RS01710	COG1538	Outer membrane efflux protein
HL41_RS01715	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HL41_RS01725	COG0497	DNA recombination
HL41_RS01740	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HL41_RS01750	COG2204	response regulator
HL41_RS01755	COG1635	Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur
HL41_RS01760	COG0322	excinuclease ABC activity
HL41_RS01765	COG0473	3-isopropylmalate dehydrogenase activity
HL41_RS01770	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HL41_RS01780	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HL41_RS01785	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HL41_RS01790	COG0445	tRNA wobble uridine modification
HL41_RS01805	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HL41_RS01815	COG0482	sulfurtransferase activity
HL41_RS01850	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HL41_RS01860	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HL41_RS01870	COG0535	radical SAM domain protein
HL41_RS01875	COG0138	bifunctional purine biosynthesis protein purh
HL41_RS01885	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HL41_RS01890	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HL41_RS01895	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HL41_RS01900	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HL41_RS01905	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
HL41_RS01915	COG1796	DNA polymerase
HL41_RS01915	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
HL41_RS01920	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HL41_RS01930	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
HL41_RS01935	COG0187	DNA topoisomerase II activity
HL41_RS01940	COG0592	DNA-directed DNA polymerase activity
HL41_RS01945	COG0492	ferredoxin-NADP+ reductase activity
HL41_RS01950	COG1619	proteins homologs of microcin C7 resistance protein MccF
HL41_RS01955	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
HL41_RS01960	COG2264	protein methyltransferase activity
HL41_RS01965	COG0501	Belongs to the peptidase M48B family
HL41_RS01970	COG0077	Prephenate dehydratase
HL41_RS01970	COG1605	Chorismate mutase
HL41_RS01980	COG0195	Participates in both transcription termination and antitermination
HL41_RS01985	COG0779	Required for maturation of 30S ribosomal subunits
HL41_RS02000	COG2204	response regulator
HL41_RS02005	COG2855	membrane
HL41_RS02030	COG2814	Major facilitator Superfamily
HL41_RS02040	COG0067	glutamate synthase
HL41_RS02055	COG0174	glutamine synthetase
HL41_RS02065	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HL41_RS02065	COG0519	Catalyzes the synthesis of GMP from XMP
HL41_RS02070	COG0347	Belongs to the P(II) protein family
HL41_RS02075	COG0004	ammonium transporteR
HL41_RS02085	COG2059	Chromate
HL41_RS02100	COG0531	amino acid
HL41_RS02125	COG1763	Mo-molybdopterin cofactor biosynthetic process
HL41_RS02130	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HL41_RS02140	COG1013	pyruvate-flavodoxin oxidoreductase activity
HL41_RS02145	COG0674	pyruvate-flavodoxin oxidoreductase activity
HL41_RS02160	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HL41_RS02170	COG0444	Belongs to the ABC transporter superfamily
HL41_RS02175	COG4608	Belongs to the ABC transporter superfamily
HL41_RS02180	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HL41_RS02185	COG0277	FAD linked oxidase domain protein
HL41_RS02190	COG0037	tRNA processing
HL41_RS02200	COG2204	response regulator
HL41_RS02210	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
HL41_RS02220	COG2200	EAL domain
HL41_RS02250	COG0166	Belongs to the GPI family
HL41_RS02255	COG0113	porphobilinogen synthase activity
HL41_RS02260	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HL41_RS02275	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HL41_RS02285	COG0735	belongs to the Fur family
HL41_RS02290	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HL41_RS02300	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HL41_RS02305	COG2414	aldehyde ferredoxin oxidoreductase
HL41_RS02310	COG1294	oxidase, subunit
HL41_RS02315	COG1271	oxidase subunit
HL41_RS02330	COG3300	MHYT domain
HL41_RS02330	COG5001	Diguanylate cyclase
HL41_RS02335	COG0469	pyruvate kinase activity
HL41_RS02350	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HL41_RS02385	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HL41_RS02390	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
HL41_RS02400	COG0310	cobalt ion transport
HL41_RS02405	COG0310	cobalt ion transport
HL41_RS02410	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
HL41_RS02425	COG0701	Predicted permease
HL41_RS02435	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HL41_RS02445	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
HL41_RS02465	COG0484	heat shock protein binding
HL41_RS02475	COG2201	protein-glutamate methylesterase activity
HL41_RS02480	COG0745	RESPONSE REGULATOR receiver
HL41_RS02505	COG1191	sigma factor activity
HL41_RS02515	COG1419	protein localization to endoplasmic reticulum
HL41_RS02520	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HL41_RS02525	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HL41_RS02530	COG1684	flagellar biosynthetic protein fliR
HL41_RS02535	COG1987	bacterial-type flagellum assembly
HL41_RS02540	COG1338	Plays a role in the flagellum-specific transport system
HL41_RS02575	COG1519	Transferase
HL41_RS02580	COG1496	oxidoreductase activity
HL41_RS02585	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HL41_RS02605	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HL41_RS02610	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HL41_RS02615	COG1489	DNA binding
HL41_RS02630	COG0730	response to heat
HL41_RS02645	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HL41_RS02655	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
HL41_RS02660	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HL41_RS02665	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HL41_RS02675	COG1137	ATPase activity
HL41_RS02700	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
HL41_RS02710	COG0840	transmembrane signaling receptor activity
HL41_RS02725	COG0840	transmembrane signaling receptor activity
HL41_RS02735	COG0840	transmembrane signaling receptor activity
HL41_RS02735	COG5278	phosphoserine phosphatase activity
HL41_RS02740	COG1090	epimerase
HL41_RS02750	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HL41_RS02755	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HL41_RS02760	COG0803	Belongs to the bacterial solute-binding protein 9 family
HL41_RS02785	COG0719	Fe-S assembly protein
HL41_RS02790	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HL41_RS02795	COG5001	Diguanylate cyclase
HL41_RS02795	COG5002	protein histidine kinase activity
HL41_RS02835	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HL41_RS02840	COG1253	flavin adenine dinucleotide binding
HL41_RS02845	COG0815	Transfers the fatty acyl group on membrane lipoproteins
HL41_RS02850	COG0163	prenyltransferase activity
HL41_RS02855	COG0328	RNA-DNA hybrid ribonuclease activity
HL41_RS02860	COG0840	transmembrane signaling receptor activity
HL41_RS02885	COG0835	chemotaxis
HL41_RS02890	COG0643	Histidine kinase
HL41_RS02890	COG2198	Histidine kinase
HL41_RS02895	COG0697	spore germination
HL41_RS02900	COG1187	pseudouridine synthase activity
HL41_RS02910	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HL41_RS02920	COG0037	tRNA processing
HL41_RS02935	COG0704	Plays a role in the regulation of phosphate uptake
HL41_RS02940	COG0681	Belongs to the peptidase S26 family
HL41_RS02945	COG0481	GTPase activity
HL41_RS02955	COG1131	(ABC) transporter
HL41_RS02970	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HL41_RS02975	COG0439	Biotin carboxylase
HL41_RS02980	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HL41_RS02995	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HL41_RS03010	COG0268	Binds directly to 16S ribosomal RNA
HL41_RS03020	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HL41_RS03025	COG1355	regulation of microtubule-based process
HL41_RS03030	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
HL41_RS03035	COG3266	domain, Protein
HL41_RS03035	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HL41_RS03045	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HL41_RS03055	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HL41_RS03065	COG2095	MarC family integral membrane protein
HL41_RS03070	COG0531	amino acid
HL41_RS03080	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HL41_RS03085	COG0577	efflux transmembrane transporter activity
HL41_RS03085	COG1136	(ABC) transporter
HL41_RS03090	COG1136	(ABC) transporter
HL41_RS03090	COG0577	efflux transmembrane transporter activity
HL41_RS03095	COG0577	efflux transmembrane transporter activity
HL41_RS03095	COG1136	(ABC) transporter
HL41_RS03100	COG0210	DNA helicase
HL41_RS03115	COG5001	Diguanylate cyclase
HL41_RS03115	COG3300	MHYT domain
HL41_RS03120	COG1196	nuclear chromosome segregation
HL41_RS03130	COG0525	valine-tRNA ligase activity
HL41_RS03135	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HL41_RS03195	COG0602	queuosine metabolic process
HL41_RS03220	COG1253	flavin adenine dinucleotide binding
HL41_RS03225	COG1253	flavin adenine dinucleotide binding
HL41_RS03260	COG0864	Transcriptional regulator
HL41_RS03265	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HL41_RS03270	COG0557	exoribonuclease II activity
HL41_RS03280	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HL41_RS03285	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
HL41_RS03290	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
HL41_RS03295	COG0756	dUTP diphosphatase activity
HL41_RS03310	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HL41_RS03315	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HL41_RS03325	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HL41_RS03345	COG0590	tRNA wobble adenosine to inosine editing
HL41_RS03350	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HL41_RS03355	COG2003	Belongs to the UPF0758 family
HL41_RS03365	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
HL41_RS03370	COG2877	3-deoxy-8-phosphooctulonate synthase activity
HL41_RS03375	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HL41_RS03385	COG0137	argininosuccinate synthase activity
HL41_RS03390	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HL41_RS03395	COG0671	phosphoesterase, PA-phosphatase related
HL41_RS03400	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
HL41_RS03405	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HL41_RS03415	COG0107	imidazoleglycerol-phosphate synthase activity
HL41_RS03430	COG0105	UTP biosynthetic process
HL41_RS03435	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
HL41_RS03445	COG0542	response to heat
HL41_RS03460	COG0456	acetyltransferase
HL41_RS03470	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HL41_RS03470	COG0574	Belongs to the PEP-utilizing enzyme family
HL41_RS03475	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HL41_RS03480	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HL41_RS03485	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HL41_RS03520	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HL41_RS03530	COG0181	hydroxymethylbilane synthase activity
HL41_RS03540	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HL41_RS03545	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HL41_RS03555	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HL41_RS03565	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
HL41_RS03570	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HL41_RS03575	COG0180	Tryptophanyl-tRNA synthetase
HL41_RS03590	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
HL41_RS03605	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
HL41_RS03615	COG0513	Belongs to the DEAD box helicase family
HL41_RS03620	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HL41_RS03625	COG0521	Mo-molybdopterin cofactor biosynthetic process
HL41_RS03635	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
HL41_RS03645	COG0583	DNA-binding transcription factor activity
HL41_RS03655	COG0425	Belongs to the sulfur carrier protein TusA family
HL41_RS03675	COG2721	sulfolactate sulfo-lyase activity
HL41_RS03680	COG2721	sulfolactate sulfo-lyase activity
HL41_RS03690	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
HL41_RS03705	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HL41_RS03725	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HL41_RS03730	COG2067	long-chain fatty acid transport protein
HL41_RS03740	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HL41_RS03745	COG2045	Belongs to the ComB family
HL41_RS03780	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HL41_RS03785	COG1462	curli production assembly transport component CsgG
HL41_RS03825	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HL41_RS03825	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HL41_RS03830	COG0174	glutamine synthetase
HL41_RS03850	COG0489	protein tyrosine kinase activity
HL41_RS03865	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
HL41_RS03870	COG1516	flagellar protein fliS
HL41_RS03885	COG3706	GGDEF domain
HL41_RS03900	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HL41_RS03905	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HL41_RS03910	COG0134	indole-3-glycerol-phosphate synthase activity
HL41_RS03915	COG0230	Belongs to the bacterial ribosomal protein bL34 family
HL41_RS03920	COG0594	ribonuclease P activity
HL41_RS03925	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
HL41_RS03930	COG0706	membrane insertase activity
HL41_RS03940	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HL41_RS03945	COG0351	phosphomethylpyrimidine kinase
HL41_RS03950	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HL41_RS03955	COG0154	amidase activity
HL41_RS03960	COG1475	DNA binding
HL41_RS03970	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HL41_RS03990	COG1058	Belongs to the CinA family
HL41_RS03990	COG1546	Belongs to the CinA family
HL41_RS03995	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HL41_RS04005	COG0475	glutathione-regulated potassium exporter activity
HL41_RS04005	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HL41_RS04015	COG3620	sequence-specific DNA binding
HL41_RS04015	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HL41_RS04015	COG0617	tRNA 3'-terminal CCA addition
HL41_RS04020	COG4974	Belongs to the 'phage' integrase family
HL41_RS04030	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HL41_RS04050	COG0010	Belongs to the arginase family
HL41_RS04065	COG0730	response to heat
HL41_RS04070	COG1522	sequence-specific DNA binding
HL41_RS04095	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HL41_RS04100	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
HL41_RS04105	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
HL41_RS04110	COG1458	PINc domain ribonuclease
HL41_RS04120	COG0495	leucyl-tRNA aminoacylation
HL41_RS04130	COG0538	isocitrate dehydrogenase activity
HL41_RS04135	COG1067	ATP-dependent peptidase activity
HL41_RS04145	COG0436	Aminotransferase
HL41_RS04165	COG1980	fructose-bisphosphate aldolase activity
HL41_RS04170	COG2257	FlhB HrpN YscU SpaS Family
HL41_RS04175	COG0509	glycine decarboxylation via glycine cleavage system
HL41_RS04180	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HL41_RS04205	COG1490	D-aminoacyl-tRNA deacylase activity
HL41_RS04215	COG0438	transferase activity, transferring glycosyl groups
HL41_RS04220	COG0438	transferase activity, transferring glycosyl groups
HL41_RS04230	COG1877	trehalose-phosphatase activity
HL41_RS04240	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
HL41_RS04255	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HL41_RS04265	COG0501	Belongs to the peptidase M48B family
HL41_RS04270	COG1132	(ABC) transporter
HL41_RS04280	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HL41_RS04285	COG1530	ribonuclease E activity
HL41_RS04295	COG1185	polyribonucleotide nucleotidyltransferase activity
HL41_RS04300	COG3301	Polysulphide reductase, NrfD
HL41_RS04315	COG1333	cytochrome c biogenesis protein
HL41_RS04320	COG0793	Belongs to the peptidase S41A family
HL41_RS04325	COG1994	Peptidase M50
HL41_RS04350	COG0778	Nitroreductase
HL41_RS04375	COG1663	tetraacyldisaccharide 4'-kinase activity
HL41_RS04390	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HL41_RS04400	COG0284	orotidine-5'-phosphate decarboxylase activity
HL41_RS04405	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HL41_RS04410	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HL41_RS04410	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
HL41_RS04415	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HL41_RS04420	COG1872	DUF167
HL41_RS04445	COG3706	GGDEF domain
HL41_RS04455	COG0459	protein refolding
HL41_RS04460	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HL41_RS04470	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HL41_RS04490	COG0430	RNA-3'-phosphate cyclase activity
HL41_RS04500	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HL41_RS04510	COG2204	response regulator
HL41_RS04515	COG4191	Histidine kinase
HL41_RS04520	COG0463	Glycosyl transferase, family 2
HL41_RS04520	COG1216	Glycosyl transferase, family 2
HL41_RS04525	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HL41_RS04535	COG1605	Chorismate mutase
HL41_RS04535	COG0287	Prephenate dehydrogenase
HL41_RS04540	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HL41_RS04545	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HL41_RS04555	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HL41_RS04565	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HL41_RS04570	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
HL41_RS04575	COG0307	riboflavin synthase, alpha
HL41_RS04585	COG0135	phosphoribosylanthranilate isomerase activity
HL41_RS04610	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
HL41_RS04620	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HL41_RS04625	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HL41_RS04635	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HL41_RS04640	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HL41_RS04645	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HL41_RS04660	COG0275	rRNA processing
HL41_RS04665	COG2001	Belongs to the MraZ family
HL41_RS04685	COG0489	protein tyrosine kinase activity
HL41_RS04710	COG4974	Belongs to the 'phage' integrase family
HL41_RS04755	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HL41_RS04760	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HL41_RS04765	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HL41_RS04770	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HL41_RS04775	COG0138	bifunctional purine biosynthesis protein purh
HL41_RS04780	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HL41_RS04795	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HL41_RS04800	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HL41_RS04815	COG1127	ABC transporter
HL41_RS04825	COG0129	dihydroxy-acid dehydratase activity
HL41_RS04830	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
HL41_RS04835	COG1758	RNA polymerase activity
HL41_RS04840	COG0484	heat shock protein binding
HL41_RS04845	COG0315	cyclic pyranopterin monophosphate synthase activity
HL41_RS04850	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HL41_RS04855	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HL41_RS04860	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HL41_RS04860	COG2221	Nitrite and sulphite reductase 4Fe-4S
HL41_RS04870	COG1187	pseudouridine synthase activity
HL41_RS04875	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HL41_RS04875	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HL41_RS04880	COG0517	IMP dehydrogenase activity
HL41_RS04895	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HL41_RS04900	COG0750	zinc metalloprotease
HL41_RS04905	COG1214	PFAM Peptidase M22, glycoprotease
HL41_RS04910	COG0601	transmembrane transport
HL41_RS04915	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HL41_RS04925	COG0586	Pfam SNARE associated Golgi protein
HL41_RS04930	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
HL41_RS04935	COG1674	ftsk spoiiie
HL41_RS04955	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
HL41_RS04960	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
HL41_RS04970	COG0298	carbon dioxide binding
HL41_RS04975	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HL41_RS04985	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
HL41_RS04995	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HL41_RS05000	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HL41_RS05005	COG4956	integral membrane protein (PIN domain superfamily)
HL41_RS05020	COG2252	PERMEase
HL41_RS05030	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HL41_RS05035	COG0557	exoribonuclease II activity
HL41_RS05060	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HL41_RS05090	COG3328	transposase activity
HL41_RS05095	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HL41_RS05100	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HL41_RS05105	COG0740	serine-type endopeptidase activity
HL41_RS05110	COG0544	peptidyl-prolyl cis-trans isomerase activity
HL41_RS05115	COG0617	tRNA 3'-terminal CCA addition
HL41_RS05120	COG0203	ribosomal protein L17
HL41_RS05125	COG0202	RNA polymerase activity
HL41_RS05130	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HL41_RS05135	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HL41_RS05145	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HL41_RS05150	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HL41_RS05160	COG0563	adenylate kinase activity
HL41_RS05165	COG0201	protein transport
HL41_RS05170	COG0200	Binds to the 23S rRNA
HL41_RS05175	COG1841	ribosomal large subunit assembly
HL41_RS05180	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HL41_RS05185	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HL41_RS05190	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HL41_RS05195	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HL41_RS05200	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HL41_RS05205	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HL41_RS05210	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HL41_RS05220	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HL41_RS05225	COG0255	Belongs to the universal ribosomal protein uL29 family
HL41_RS05235	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HL41_RS05240	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HL41_RS05245	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HL41_RS05250	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HL41_RS05255	COG0089	rRNA binding
HL41_RS05265	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HL41_RS05270	COG0051	transcription antitermination factor activity, RNA binding
HL41_RS05275	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HL41_RS05280	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HL41_RS05285	COG0049	tRNA binding
HL41_RS05290	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HL41_RS05295	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HL41_RS05315	COG0463	Glycosyl transferase, family 2
HL41_RS05320	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HL41_RS05325	COG2131	deaminase
HL41_RS05330	COG0484	heat shock protein binding
HL41_RS05345	COG0778	Nitroreductase
HL41_RS05350	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HL41_RS05355	COG2078	PFAM AMMECR1 domain protein
HL41_RS05360	COG0039	L-malate dehydrogenase activity
HL41_RS05370	COG0778	Nitroreductase
HL41_RS05375	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HL41_RS05380	COG2078	PFAM AMMECR1 domain protein
HL41_RS05395	COG0484	heat shock protein binding
HL41_RS05400	COG0527	aspartate kinase activity
HL41_RS05405	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HL41_RS05415	COG0215	cysteine-tRNA ligase activity
HL41_RS05425	COG0131	Imidazoleglycerol-phosphate dehydratase
HL41_RS05435	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HL41_RS05440	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HL41_RS05445	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HL41_RS05455	COG0330	HflC and HflK could
HL41_RS05465	COG0028	Belongs to the TPP enzyme family
HL41_RS05470	COG0440	acetolactate synthase activity
HL41_RS05480	COG0805	protein transport
HL41_RS05485	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HL41_RS05495	COG2221	Nitrite and sulphite reductase 4Fe-4S
HL41_RS05500	COG2221	Nitrite and sulphite reductase 4Fe-4S
HL41_RS05505	COG2884	Cell division ATP-binding protein ftsE
HL41_RS05540	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HL41_RS05545	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HL41_RS05560	COG1028	Short-chain dehydrogenase reductase Sdr
HL41_RS05565	COG0432	Pfam Uncharacterised protein family UPF0047
HL41_RS05575	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HL41_RS05630	COG0632	four-way junction helicase activity
HL41_RS05635	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
HL41_RS05640	COG0217	transcriptional regulatory protein
HL41_RS05650	COG1773	rubredoxin
HL41_RS05650	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HL41_RS05665	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HL41_RS05665	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HL41_RS05670	COG0237	dephospho-CoA kinase activity
HL41_RS05675	COG0564	pseudouridine synthase activity
HL41_RS05680	COG0123	including yeast histone deacetylase and acetoin utilization protein
HL41_RS05690	COG0196	riboflavin kinase activity
HL41_RS05695	COG0505	Belongs to the CarA family
HL41_RS05710	COG0426	domain, Protein
HL41_RS05720	COG1773	rubredoxin
HL41_RS05725	COG2033	superoxide reductase activity
HL41_RS05740	COG0072	phenylalanine-tRNA ligase activity
HL41_RS05745	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HL41_RS05750	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HL41_RS05755	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HL41_RS05765	COG2255	four-way junction helicase activity
HL41_RS05790	COG1918	ferrous iron import across plasma membrane
HL41_RS05790	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
HL41_RS05795	COG1918	ferrous iron import across plasma membrane
HL41_RS05805	COG3706	GGDEF domain
HL41_RS05815	COG0450	alkyl hydroperoxide reductase
HL41_RS05830	COG1592	Rubrerythrin
HL41_RS05855	COG1007	ATP synthesis coupled electron transport
HL41_RS05870	COG0713	ATP synthesis coupled electron transport
HL41_RS05875	COG0839	Belongs to the complex I subunit 6 family
HL41_RS05880	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HL41_RS05885	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
HL41_RS05890	COG0649	NAD binding
HL41_RS05895	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HL41_RS05900	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HL41_RS05910	COG0437	4 iron, 4 sulfur cluster binding
HL41_RS05920	COG1832	CoA-binding protein
HL41_RS05925	COG0126	phosphoglycerate kinase activity
HL41_RS05925	COG0149	triose-phosphate isomerase activity
HL41_RS05930	COG0126	phosphoglycerate kinase activity
HL41_RS05950	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HL41_RS05950	COG0574	Belongs to the PEP-utilizing enzyme family
HL41_RS05955	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HL41_RS05960	COG0419	ATPase involved in DNA repair
HL41_RS05965	COG0746	molybdenum cofactor guanylyltransferase activity
HL41_RS05985	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HL41_RS05990	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
HL41_RS05995	COG0811	peptide transport
HL41_RS06000	COG3118	belongs to the thioredoxin family
HL41_RS06015	COG0653	protein targeting
HL41_RS06020	COG0585	pseudouridine synthase activity
HL41_RS06025	COG0859	PFAM glycosyl transferase family 9
HL41_RS06030	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HL41_RS06040	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HL41_RS06080	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HL41_RS06150	COG1151	hydroxylamine reductase activity
HL41_RS06160	COG1088	dTDP-glucose 4,6-dehydratase activity
HL41_RS06175	COG0589	response to stress
HL41_RS06190	COG0232	Belongs to the dGTPase family. Type 2 subfamily
HL41_RS06195	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
HL41_RS06195	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HL41_RS06205	COG0492	ferredoxin-NADP+ reductase activity
HL41_RS06215	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HL41_RS06225	COG3876	Protein conserved in bacteria
HL41_RS06240	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HL41_RS06245	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HL41_RS06250	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HL41_RS06260	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
HL41_RS06265	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HL41_RS06270	COG1131	(ABC) transporter
HL41_RS06275	COG0842	Transport permease protein
HL41_RS06280	COG0842	Transport permease protein
HL41_RS06290	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HL41_RS06295	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
HL41_RS06300	COG0629	single-stranded DNA binding
HL41_RS06325	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HL41_RS06330	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HL41_RS06330	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
HL41_RS06335	COG0148	phosphopyruvate hydratase activity
HL41_RS06345	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HL41_RS06365	COG1773	rubredoxin
HL41_RS06375	COG0470	DNA polymerase III
HL41_RS06380	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HL41_RS06385	COG2890	protein-(glutamine-N5) methyltransferase activity
HL41_RS06390	COG2264	protein methyltransferase activity
HL41_RS06400	COG1459	type II secretion system
HL41_RS06405	COG0516	GMP reductase activity
HL41_RS06405	COG0517	IMP dehydrogenase activity
HL41_RS06410	COG0248	Ppx GppA phosphatase
HL41_RS06410	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HL41_RS06415	COG0616	signal peptide processing
HL41_RS06420	COG0539	negative regulation of cytoplasmic translation
HL41_RS06450	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
HL41_RS06455	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
HL41_RS06465	COG0012	GTP binding
HL41_RS06485	COG0058	SHG alpha-glucan phosphorylase activity
HL41_RS06500	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HL41_RS06520	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
HL41_RS06525	COG0742	ribosomal rna small subunit methyltransferase
HL41_RS06540	COG1472	Belongs to the glycosyl hydrolase 3 family
HL41_RS06545	COG1104	cysteine desulfurase activity
HL41_RS06550	COG1110	DNA topoisomerase II activity
HL41_RS06555	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HL41_RS06560	COG0516	GMP reductase activity
HL41_RS06560	COG0517	IMP dehydrogenase activity
HL41_RS06565	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
HL41_RS06855	COG0629	single-stranded DNA binding
HL41_RS06870	COG1077	Cell shape determining protein MreB Mrl
HL41_RS06880	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HL41_RS06880	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HL41_RS06885	COG0436	Aminotransferase
HL41_RS06890	COG1260	myo-inositol-1-phosphate synthase
HL41_RS06895	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HL41_RS06905	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HL41_RS06905	COG0512	Glutamine amidotransferase of anthranilate synthase
HL41_RS06915	COG0124	histidyl-tRNA synthetase
HL41_RS06920	COG0446	pyridine nucleotide-disulphide oxidoreductase
HL41_RS06925	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
HL41_RS06925	COG1918	ferrous iron import across plasma membrane
HL41_RS06930	COG0006	proline dipeptidase activity
HL41_RS06945	COG0352	thiamine-phosphate diphosphorylase activity
HL41_RS06950	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HL41_RS06965	COG5000	phosphorelay sensor kinase activity
HL41_RS06970	COG2204	response regulator
HL41_RS07005	COG0247	lactate metabolic process
HL41_RS07010	COG0277	FAD linked oxidase domain protein
HL41_RS07015	COG1620	l-lactate permease
HL41_RS07025	COG0857	belongs to the CobB CobQ family
HL41_RS07040	COG0674	pyruvate-flavodoxin oxidoreductase activity
HL41_RS07045	COG1013	pyruvate-flavodoxin oxidoreductase activity
HL41_RS07065	COG2111	Na H antiporter
HL41_RS07065	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HL41_RS07070	COG0651	ATP synthesis coupled electron transport
HL41_RS07075	COG3260	NADH ubiquinone oxidoreductase 20
HL41_RS07105	COG2226	methyltransferase
HL41_RS07115	COG0402	S-adenosylhomocysteine deaminase activity
HL41_RS07120	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
HL41_RS07125	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
HL41_RS07140	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HL41_RS07145	COG1376	ErfK ybiS ycfS ynhG family protein
HL41_RS07150	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
HL41_RS07155	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HL41_RS07160	COG0540	Belongs to the ATCase OTCase family
HL41_RS07165	COG1611	Belongs to the LOG family
HL41_RS07180	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HL41_RS07190	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HL41_RS07195	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HL41_RS07210	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HL41_RS07220	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HL41_RS07235	COG4783	chaperone-mediated protein folding
HL41_RS07260	COG2217	Heavy metal translocating P-type atpase
HL41_RS07270	COG3287	FIST C domain
HL41_RS07275	COG2199	diguanylate cyclase activity
HL41_RS07275	COG2203	Gaf domain
HL41_RS07305	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HL41_RS07310	COG1469	GTP cyclohydrolase I activity
HL41_RS07355	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HL41_RS07360	COG2759	Belongs to the formate--tetrahydrofolate ligase family
HL41_RS07380	COG0837	glucose binding
HL41_RS07385	COG0802	atpase or kinase
HL41_RS07390	COG0612	Peptidase, M16
HL41_RS07435	COG1518	maintenance of DNA repeat elements
HL41_RS07440	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
HL41_RS07445	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HL41_RS07465	COG2361	Protein of unknown function DUF86
HL41_RS07485	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HL41_RS07490	COG0535	radical SAM domain protein
HL41_RS07495	COG1408	metallophosphoesterase
HL41_RS07500	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HL41_RS07530	COG0840	transmembrane signaling receptor activity
HL41_RS07540	COG0438	transferase activity, transferring glycosyl groups
HL41_RS07560	COG0438	transferase activity, transferring glycosyl groups
HL41_RS07565	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
HL41_RS07580	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HL41_RS07585	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HL41_RS07590	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HL41_RS07595	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HL41_RS07605	COG0133	tryptophan synthase activity
HL41_RS07610	COG0159	tryptophan synthase activity
HL41_RS07615	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HL41_RS07620	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HL41_RS07625	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HL41_RS07630	COG0655	NAD(P)H dehydrogenase (quinone) activity
HL41_RS07640	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HL41_RS07655	COG2200	EAL domain
HL41_RS07665	COG0587	DNA-directed DNA polymerase activity
HL41_RS07670	COG1528	Iron-storage protein
HL41_RS07675	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HL41_RS07675	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HL41_RS07680	COG0556	nucleotide-excision repair
HL41_RS07700	COG0254	rRNA binding
HL41_RS07705	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HL41_RS07735	COG0085	RNA polymerase activity
HL41_RS07765	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
HL41_RS07780	COG0475	glutathione-regulated potassium exporter activity
HL41_RS07785	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HL41_RS07795	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
HL41_RS07800	COG0420	3'-5' exonuclease activity
HL41_RS07805	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HL41_RS07825	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HL41_RS07835	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HL41_RS07840	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HL41_RS07850	COG0303	'Molybdopterin
HL41_RS07860	COG2204	response regulator
HL41_RS07865	COG4191	Histidine kinase
HL41_RS07875	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HL41_RS07875	COG0574	Belongs to the PEP-utilizing enzyme family
HL41_RS07880	COG2188	Transcriptional regulator
HL41_RS07905	COG0589	response to stress
HL41_RS07920	COG0589	response to stress
HL41_RS07940	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
HL41_RS07945	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
HL41_RS07950	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HL41_RS07955	COG0581	inorganic phosphate transmembrane transporter activity
HL41_RS07965	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HL41_RS07970	COG0745	RESPONSE REGULATOR receiver
HL41_RS07975	COG5002	protein histidine kinase activity
HL41_RS07980	COG4206	TonB-dependent receptor
HL41_RS07985	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HL41_RS07990	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HL41_RS08005	COG0437	4 iron, 4 sulfur cluster binding
HL41_RS08015	COG0552	protein localization to endoplasmic reticulum
HL41_RS08060	COG1027	Aspartate ammonia-lyase
HL41_RS08075	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HL41_RS08080	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HL41_RS08110	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HL41_RS08115	COG3162	membrane
HL41_RS08135	COG0312	modulator of DNA gyrase
HL41_RS08140	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HL41_RS08145	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HL41_RS08155	COG0442	prolyl-tRNA aminoacylation
HL41_RS08160	COG3158	transport of potassium into the cell
HL41_RS08180	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
HL41_RS08190	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
HL41_RS08195	COG1910	domain protein
HL41_RS08205	COG0437	4 iron, 4 sulfur cluster binding
HL41_RS08225	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
HL41_RS08230	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
HL41_RS08240	COG2181	nitrate reductase activity
HL41_RS08245	COG0247	lactate metabolic process
HL41_RS08250	COG0484	heat shock protein binding
HL41_RS08255	COG0437	4 iron, 4 sulfur cluster binding
HL41_RS08255	COG3064	Membrane
HL41_RS08260	COG5557	Pfam Polysulphide reductase, NrfD
HL41_RS08270	COG0437	4 iron, 4 sulfur cluster binding
HL41_RS08275	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HL41_RS08280	COG0649	NAD binding
HL41_RS08285	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HL41_RS08290	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HL41_RS08300	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
HL41_RS08305	COG0839	Belongs to the complex I subunit 6 family
HL41_RS08310	COG0713	ATP synthesis coupled electron transport
HL41_RS08315	COG0651	ATP synthesis coupled electron transport
HL41_RS08325	COG0651	ATP synthesis coupled electron transport
HL41_RS08335	COG1007	ATP synthesis coupled electron transport
HL41_RS08345	COG2204	response regulator
HL41_RS08350	COG4191	Histidine kinase
HL41_RS08360	COG0492	ferredoxin-NADP+ reductase activity
HL41_RS08375	COG0375	protein maturation
HL41_RS08380	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
HL41_RS08385	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
HL41_RS08425	COG0546	phosphoglycolate phosphatase activity
HL41_RS08440	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HL41_RS08455	COG0360	Binds together with S18 to 16S ribosomal RNA
HL41_RS08465	COG0359	binds to the 23S rRNA
HL41_RS08470	COG0305	Participates in initiation and elongation during chromosome replication
HL41_RS08480	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HL41_RS08500	COG1074	ATP-dependent DNA helicase activity
HL41_RS08510	COG0142	geranyltranstransferase activity
HL41_RS08515	COG2046	Belongs to the sulfate adenylyltransferase family
HL41_RS08565	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HL41_RS08570	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HL41_RS08590	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HL41_RS08595	COG0081	regulation of translation
HL41_RS08605	COG0222	ribosome binding
HL41_RS08610	COG0085	RNA polymerase activity
HL41_RS08615	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HL41_RS08620	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HL41_RS08625	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HL41_RS08630	COG1254	Belongs to the acylphosphatase family
HL41_RS08635	COG2195	Cleaves the N-terminal amino acid of tripeptides
HL41_RS08640	COG1040	competence protein
HL41_RS08645	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
HL41_RS08645	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HL41_RS08655	COG3034	peptidoglycan biosynthetic process
HL41_RS08665	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
HL41_RS08670	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HL41_RS08675	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
HL41_RS08680	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
HL41_RS08700	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HL41_RS08705	COG1120	ATPase activity
HL41_RS08715	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
HL41_RS08720	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
HL41_RS08720	COG1240	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
HL41_RS08745	COG0517	IMP dehydrogenase activity
HL41_RS08745	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HL41_RS08770	COG0167	dihydroorotate dehydrogenase activity
HL41_RS08775	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
HL41_RS08785	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HL41_RS08790	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HL41_RS08795	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HL41_RS08830	COG3259	Nickel-dependent hydrogenase
HL41_RS08860	COG0425	Belongs to the sulfur carrier protein TusA family
HL41_RS08860	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HL41_RS08880	COG0628	permease
HL41_RS08895	COG1596	polysaccharide export
HL41_RS08895	COG1555	photosystem II stabilization
HL41_RS08900	COG4968	Prepilin-type N-terminal cleavage methylation domain
HL41_RS08905	COG4589	Belongs to the CDS family
HL41_RS08915	COG2823	Periplasmic or secreted lipoprotein
HL41_RS08925	COG0710	3-dehydroquinate dehydratase activity
HL41_RS08930	COG1686	Belongs to the peptidase S11 family
HL41_RS08995	COG3706	GGDEF domain
HL41_RS09020	COG2197	response regulator
HL41_RS09030	COG3706	GGDEF domain
HL41_RS09035	COG0358	DNA primase activity
HL41_RS09050	COG0038	chloride channel
HL41_RS09055	COG0840	transmembrane signaling receptor activity
HL41_RS09055	COG3290	protein histidine kinase activity
HL41_RS09060	COG3706	GGDEF domain
HL41_RS09060	COG2203	Gaf domain
HL41_RS09060	COG4251	negative regulation of phosphorylation
HL41_RS09060	COG5001	Diguanylate cyclase
HL41_RS09080	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HL41_RS09090	COG1749	Flagellar hook protein flgE
HL41_RS09115	COG0312	modulator of DNA gyrase
HL41_RS09120	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
HL41_RS09150	COG0741	lytic transglycosylase activity
HL41_RS09155	COG2885	chlorophyll binding
HL41_RS09165	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HL41_RS09170	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
HL41_RS09175	COG0489	protein tyrosine kinase activity
HL41_RS09180	COG1295	ribonuclease BN
HL41_RS09195	COG1193	negative regulation of DNA recombination
HL41_RS09200	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HL41_RS09205	COG0791	NLP P60 protein
HL41_RS09205	COG1388	LysM domain