locus-tag	class	description
TOPB45_RS00010	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
TOPB45_RS00015	COG0277	FAD linked oxidase domain protein
TOPB45_RS00020	COG0037	tRNA processing
TOPB45_RS00025	COG0741	lytic transglycosylase activity
TOPB45_RS00030	COG0668	transmembrane transport
TOPB45_RS00065	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
TOPB45_RS00065	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
TOPB45_RS00075	COG0698	ribose 5-phosphate isomerase
TOPB45_RS00080	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
TOPB45_RS00085	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
TOPB45_RS00100	COG0635	Involved in the biosynthesis of porphyrin-containing compound
TOPB45_RS00105	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
TOPB45_RS00115	COG0820	rRNA (adenine-C2-)-methyltransferase activity
TOPB45_RS00120	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
TOPB45_RS00125	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
TOPB45_RS00130	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
TOPB45_RS00135	COG0138	bifunctional purine biosynthesis protein purh
TOPB45_RS00140	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
TOPB45_RS00155	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
TOPB45_RS00160	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
TOPB45_RS00165	COG1522	sequence-specific DNA binding
TOPB45_RS00175	COG1127	ABC transporter
TOPB45_RS00185	COG0129	dihydroxy-acid dehydratase activity
TOPB45_RS00190	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
TOPB45_RS00195	COG1758	RNA polymerase activity
TOPB45_RS00200	COG0484	heat shock protein binding
TOPB45_RS00205	COG0315	cyclic pyranopterin monophosphate synthase activity
TOPB45_RS00215	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
TOPB45_RS00220	COG0516	GMP reductase activity
TOPB45_RS00220	COG0517	IMP dehydrogenase activity
TOPB45_RS00235	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
TOPB45_RS00240	COG0750	zinc metalloprotease
TOPB45_RS00245	COG1214	PFAM Peptidase M22, glycoprotease
TOPB45_RS00250	COG0601	transmembrane transport
TOPB45_RS00255	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TOPB45_RS00265	COG0733	neurotransmitter:sodium symporter activity
TOPB45_RS00290	COG2204	response regulator
TOPB45_RS00295	COG1815	bacterial-type flagellum-dependent cell motility
TOPB45_RS00305	COG1677	Flagellar hook-basal body complex protein FliE
TOPB45_RS00310	COG1766	The M ring may be actively involved in energy transduction
TOPB45_RS00315	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
TOPB45_RS00325	COG1157	protein secretion by the type III secretion system
TOPB45_RS00340	COG0805	protein transport
TOPB45_RS00345	COG0047	phosphoribosylformylglycinamidine synthase activity
TOPB45_RS00365	COG0628	permease
TOPB45_RS00380	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
TOPB45_RS00385	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
TOPB45_RS00390	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
TOPB45_RS00395	COG0193	aminoacyl-tRNA hydrolase activity
TOPB45_RS00405	COG0519	Catalyzes the synthesis of GMP from XMP
TOPB45_RS00425	COG0333	Belongs to the bacterial ribosomal protein bL32 family
TOPB45_RS00430	COG0416	fatty acid biosynthetic process
TOPB45_RS00435	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
TOPB45_RS00450	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
TOPB45_RS00460	COG1007	ATP synthesis coupled electron transport
TOPB45_RS00475	COG0713	ATP synthesis coupled electron transport
TOPB45_RS00480	COG0839	Belongs to the complex I subunit 6 family
TOPB45_RS00485	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TOPB45_RS00490	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
TOPB45_RS00495	COG0649	NAD binding
TOPB45_RS00500	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TOPB45_RS00505	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TOPB45_RS00510	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TOPB45_RS00515	COG0437	4 iron, 4 sulfur cluster binding
TOPB45_RS00525	COG1832	CoA-binding protein
TOPB45_RS00530	COG0149	triose-phosphate isomerase activity
TOPB45_RS00535	COG0126	phosphoglycerate kinase activity
TOPB45_RS00540	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
TOPB45_RS00555	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
TOPB45_RS00555	COG0574	Belongs to the PEP-utilizing enzyme family
TOPB45_RS00560	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
TOPB45_RS00570	COG0746	molybdenum cofactor guanylyltransferase activity
TOPB45_RS00595	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
TOPB45_RS00605	COG3118	belongs to the thioredoxin family
TOPB45_RS00620	COG0653	protein targeting
TOPB45_RS00625	COG0585	pseudouridine synthase activity
TOPB45_RS00630	COG0859	PFAM glycosyl transferase family 9
TOPB45_RS00640	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
TOPB45_RS00645	COG0312	modulator of DNA gyrase
TOPB45_RS00650	COG0148	phosphopyruvate hydratase activity
TOPB45_RS00655	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
TOPB45_RS00655	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
TOPB45_RS00660	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
TOPB45_RS00665	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
TOPB45_RS00670	COG0420	3'-5' exonuclease activity
TOPB45_RS00675	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
TOPB45_RS00680	COG0489	protein tyrosine kinase activity
TOPB45_RS00695	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
TOPB45_RS00700	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
TOPB45_RS00705	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TOPB45_RS00725	COG1515	deoxyribonuclease V activity
TOPB45_RS00730	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
TOPB45_RS00745	COG0732	type I restriction modification DNA specificity domain
TOPB45_RS00760	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
TOPB45_RS00765	COG1970	mechanosensitive ion channel activity
TOPB45_RS00775	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
TOPB45_RS00775	COG0426	domain, Protein
TOPB45_RS00790	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
TOPB45_RS00790	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
TOPB45_RS00795	COG0237	dephospho-CoA kinase activity
TOPB45_RS00800	COG0564	pseudouridine synthase activity
TOPB45_RS00810	COG0739	heme binding
TOPB45_RS00815	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
TOPB45_RS00820	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
TOPB45_RS00825	COG0085	RNA polymerase activity
TOPB45_RS00830	COG0222	ribosome binding
TOPB45_RS00835	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
TOPB45_RS00840	COG0081	regulation of translation
TOPB45_RS00855	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
TOPB45_RS00865	COG0267	Belongs to the bacterial ribosomal protein bL33 family
TOPB45_RS00870	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
TOPB45_RS00895	COG1233	COG1233 Phytoene dehydrogenase and related
TOPB45_RS00920	COG2046	Belongs to the sulfate adenylyltransferase family
TOPB45_RS00925	COG0142	geranyltranstransferase activity
TOPB45_RS00935	COG1074	ATP-dependent DNA helicase activity
TOPB45_RS00940	COG1385	rRNA (uridine-N3-)-methyltransferase activity
TOPB45_RS00955	COG0589	response to stress
TOPB45_RS00960	COG0305	Participates in initiation and elongation during chromosome replication
TOPB45_RS00965	COG0359	binds to the 23S rRNA
TOPB45_RS00970	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
TOPB45_RS00975	COG0360	Binds together with S18 to 16S ribosomal RNA
TOPB45_RS00985	COG0494	nUDIX hydrolase
TOPB45_RS00990	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
TOPB45_RS00995	COG1388	LysM domain
TOPB45_RS00995	COG0791	NLP P60 protein
TOPB45_RS01000	COG3706	GGDEF domain
TOPB45_RS01010	COG0517	IMP dehydrogenase activity
TOPB45_RS01010	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
TOPB45_RS01035	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
TOPB45_RS01040	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
TOPB45_RS01045	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TOPB45_RS01050	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
TOPB45_RS01055	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
TOPB45_RS01065	COG0432	Pfam Uncharacterised protein family UPF0047
TOPB45_RS01075	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
TOPB45_RS01080	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
TOPB45_RS01120	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
TOPB45_RS01125	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
TOPB45_RS01140	COG1192	Involved in chromosome partitioning
TOPB45_RS01155	COG1309	transcriptional regulator
TOPB45_RS01170	COG1538	Outer membrane efflux protein
TOPB45_RS01180	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
TOPB45_RS01190	COG0742	ribosomal rna small subunit methyltransferase
TOPB45_RS01200	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
TOPB45_RS01210	COG1104	cysteine desulfurase activity
TOPB45_RS01215	COG1110	DNA topoisomerase II activity
TOPB45_RS01220	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
TOPB45_RS01225	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
TOPB45_RS01260	COG5001	Diguanylate cyclase
TOPB45_RS01260	COG5002	protein histidine kinase activity
TOPB45_RS01275	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
TOPB45_RS01285	COG0629	single-stranded DNA binding
TOPB45_RS01290	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
TOPB45_RS01295	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
TOPB45_RS01305	COG1032	radical SAM domain protein
TOPB45_RS01325	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
TOPB45_RS01330	COG0254	rRNA binding
TOPB45_RS01340	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
TOPB45_RS01345	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
TOPB45_RS01365	COG1381	Involved in DNA repair and RecF pathway recombination
TOPB45_RS01370	COG1611	Belongs to the LOG family
TOPB45_RS01375	COG0540	Belongs to the ATCase OTCase family
TOPB45_RS01380	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
TOPB45_RS01385	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
TOPB45_RS01390	COG1376	ErfK ybiS ycfS ynhG family protein
TOPB45_RS01395	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
TOPB45_RS01415	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
TOPB45_RS01430	COG2226	methyltransferase
TOPB45_RS01445	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TOPB45_RS01450	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
TOPB45_RS01465	COG0058	SHG alpha-glucan phosphorylase activity
TOPB45_RS01485	COG0012	GTP binding
TOPB45_RS01495	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
TOPB45_RS01500	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
TOPB45_RS01510	COG2814	Major facilitator Superfamily
TOPB45_RS01515	COG1566	PFAM secretion protein HlyD family protein
TOPB45_RS01540	COG2067	long-chain fatty acid transport protein
TOPB45_RS01545	COG0166	Belongs to the GPI family
TOPB45_RS01550	COG0113	porphobilinogen synthase activity
TOPB45_RS01555	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
TOPB45_RS01560	COG0571	ribonuclease III activity
TOPB45_RS01570	COG2747	anti-sigma28 factor FlgM
TOPB45_RS01575	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
TOPB45_RS01575	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
TOPB45_RS01580	COG1040	competence protein
TOPB45_RS01585	COG2195	Cleaves the N-terminal amino acid of tripeptides
TOPB45_RS01590	COG1254	Belongs to the acylphosphatase family
TOPB45_RS01615	COG0003	Pfam Anion-transporting ATPase
TOPB45_RS01620	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
TOPB45_RS01625	COG0556	nucleotide-excision repair
TOPB45_RS01640	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
TOPB45_RS01645	COG0352	thiamine-phosphate diphosphorylase activity
TOPB45_RS01750	COG2244	polysaccharide biosynthetic process
TOPB45_RS01790	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
TOPB45_RS01820	COG0438	transferase activity, transferring glycosyl groups
TOPB45_RS01830	COG1598	PFAM Uncharacterised protein family UPF0150
TOPB45_RS01875	COG0492	ferredoxin-NADP+ reductase activity
TOPB45_RS01900	COG1077	Cell shape determining protein MreB Mrl
TOPB45_RS01910	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
TOPB45_RS01910	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
TOPB45_RS01915	COG0436	Aminotransferase
TOPB45_RS01925	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
TOPB45_RS01935	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
TOPB45_RS01935	COG0512	Glutamine amidotransferase of anthranilate synthase
TOPB45_RS01945	COG0124	histidyl-tRNA synthetase
TOPB45_RS01950	COG0446	pyridine nucleotide-disulphide oxidoreductase
TOPB45_RS01955	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
TOPB45_RS01960	COG0006	proline dipeptidase activity
TOPB45_RS01965	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
TOPB45_RS01980	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
TOPB45_RS02000	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
TOPB45_RS02005	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
TOPB45_RS02010	COG4206	TonB-dependent receptor
TOPB45_RS02040	COG0492	ferredoxin-NADP+ reductase activity
TOPB45_RS02060	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
TOPB45_RS02060	COG0646	methionine synthase
TOPB45_RS02075	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
TOPB45_RS02080	COG2759	Belongs to the formate--tetrahydrofolate ligase family
TOPB45_RS02085	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
TOPB45_RS02090	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
TOPB45_RS02090	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
TOPB45_RS02095	COG0232	Belongs to the dGTPase family. Type 2 subfamily
TOPB45_RS02110	COG0589	response to stress
TOPB45_RS02115	COG1335	isochorismatase
TOPB45_RS02120	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
TOPB45_RS02135	COG0802	atpase or kinase
TOPB45_RS02140	COG0837	glucose binding
TOPB45_RS02150	COG2885	chlorophyll binding
TOPB45_RS02165	COG0552	protein localization to endoplasmic reticulum
TOPB45_RS02180	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
TOPB45_RS02185	COG1408	metallophosphoesterase
TOPB45_RS02190	COG0179	Fumarylacetoacetate (FAA) hydrolase
TOPB45_RS02195	COG0535	radical SAM domain protein
TOPB45_RS02200	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
TOPB45_RS02215	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
TOPB45_RS02220	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
TOPB45_RS02225	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
TOPB45_RS02235	COG3876	Protein conserved in bacteria
TOPB45_RS02245	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
TOPB45_RS02250	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
TOPB45_RS02255	COG0587	DNA-directed DNA polymerase activity
TOPB45_RS02265	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
TOPB45_RS02275	COG0123	including yeast histone deacetylase and acetoin utilization protein
TOPB45_RS02280	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
TOPB45_RS02285	COG1131	(ABC) transporter
TOPB45_RS02290	COG1129	ABC transporter
TOPB45_RS02290	COG0842	Transport permease protein
TOPB45_RS02295	COG0842	Transport permease protein
TOPB45_RS02340	COG0133	tryptophan synthase activity
TOPB45_RS02345	COG0159	tryptophan synthase activity
TOPB45_RS02350	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
TOPB45_RS02355	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
TOPB45_RS02360	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
TOPB45_RS02365	COG1979	alcohol dehydrogenase
TOPB45_RS02385	COG0745	RESPONSE REGULATOR receiver
TOPB45_RS02390	COG5002	protein histidine kinase activity
TOPB45_RS02395	COG3300	MHYT domain
TOPB45_RS02395	COG5001	Diguanylate cyclase
TOPB45_RS02410	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
TOPB45_RS02420	COG0375	protein maturation
TOPB45_RS02425	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
TOPB45_RS02430	COG0589	response to stress
TOPB45_RS02445	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
TOPB45_RS02445	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
TOPB45_RS02460	COG0590	tRNA wobble adenosine to inosine editing
TOPB45_RS02480	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
TOPB45_RS02485	COG2877	3-deoxy-8-phosphooctulonate synthase activity
TOPB45_RS02510	COG0438	transferase activity, transferring glycosyl groups
TOPB45_RS02530	COG0137	argininosuccinate synthase activity
TOPB45_RS02535	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
TOPB45_RS02540	COG0671	phosphoesterase, PA-phosphatase related
TOPB45_RS02550	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
TOPB45_RS02560	COG0107	imidazoleglycerol-phosphate synthase activity
TOPB45_RS02570	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
TOPB45_RS02575	COG1324	tolerance protein
TOPB45_RS02580	COG0303	'Molybdopterin
TOPB45_RS02585	COG3383	formate dehydrogenase (NAD+) activity
TOPB45_RS02585	COG0243	molybdopterin cofactor binding
TOPB45_RS02595	COG0437	4 iron, 4 sulfur cluster binding
TOPB45_RS02605	COG1910	domain protein
TOPB45_RS02610	COG1295	ribonuclease BN
TOPB45_RS02610	COG1959	2 iron, 2 sulfur cluster binding
TOPB45_RS02620	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
TOPB45_RS02635	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
TOPB45_RS02655	COG0438	transferase activity, transferring glycosyl groups
TOPB45_RS02665	COG0438	transferase activity, transferring glycosyl groups
TOPB45_RS02690	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TOPB45_RS02695	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
TOPB45_RS02700	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
TOPB45_RS02745	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
TOPB45_RS02750	COG0573	inorganic phosphate transmembrane transporter activity
TOPB45_RS02760	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
TOPB45_RS02765	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
TOPB45_RS02770	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
TOPB45_RS02780	COG0196	riboflavin kinase activity
TOPB45_RS02785	COG0505	Belongs to the CarA family
TOPB45_RS02800	COG0426	domain, Protein
TOPB45_RS02810	COG1773	rubredoxin
TOPB45_RS02815	COG1773	rubredoxin
TOPB45_RS02820	COG1773	rubredoxin
TOPB45_RS02825	COG2033	superoxide reductase activity
TOPB45_RS02840	COG0072	phenylalanine-tRNA ligase activity
TOPB45_RS02845	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
TOPB45_RS02850	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
TOPB45_RS02855	COG0291	Belongs to the bacterial ribosomal protein bL35 family
TOPB45_RS02860	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
TOPB45_RS02865	COG2255	four-way junction helicase activity
TOPB45_RS02870	COG0840	transmembrane signaling receptor activity
TOPB45_RS02895	COG0218	Necessary for normal cell division and for the maintenance of normal septation
TOPB45_RS02905	COG0450	alkyl hydroperoxide reductase
TOPB45_RS02920	COG0312	modulator of DNA gyrase
TOPB45_RS02925	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
TOPB45_RS02930	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
TOPB45_RS02940	COG0442	prolyl-tRNA aminoacylation
TOPB45_RS02945	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
TOPB45_RS02960	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
TOPB45_RS02970	COG2703	oxygen carrier activity
TOPB45_RS02995	COG2264	protein methyltransferase activity
TOPB45_RS03010	COG0632	four-way junction helicase activity
TOPB45_RS03020	COG0217	transcriptional regulatory protein
TOPB45_RS03035	COG2084	Dehydrogenase
TOPB45_RS03055	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
TOPB45_RS03060	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
TOPB45_RS03065	COG0134	indole-3-glycerol-phosphate synthase activity
TOPB45_RS03070	COG0230	Belongs to the bacterial ribosomal protein bL34 family
TOPB45_RS03075	COG0594	ribonuclease P activity
TOPB45_RS03080	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
TOPB45_RS03085	COG0706	membrane insertase activity
TOPB45_RS03095	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
TOPB45_RS03110	COG0351	phosphomethylpyrimidine kinase
TOPB45_RS03115	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
TOPB45_RS03120	COG0154	amidase activity
TOPB45_RS03125	COG1475	DNA binding
TOPB45_RS03130	COG0438	transferase activity, transferring glycosyl groups
TOPB45_RS03145	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
TOPB45_RS03160	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
TOPB45_RS03165	COG1058	Belongs to the CinA family
TOPB45_RS03165	COG1546	Belongs to the CinA family
TOPB45_RS03170	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
TOPB45_RS03180	COG1090	epimerase
TOPB45_RS03185	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
TOPB45_RS03190	COG0589	response to stress
TOPB45_RS03200	COG1216	Glycosyl transferase, family 2
TOPB45_RS03200	COG0463	Glycosyl transferase, family 2
TOPB45_RS03205	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
TOPB45_RS03215	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
TOPB45_RS03220	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
TOPB45_RS03230	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
TOPB45_RS03235	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
TOPB45_RS03240	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
TOPB45_RS03245	COG0307	riboflavin synthase, alpha
TOPB45_RS03255	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
TOPB45_RS03260	COG0306	phosphate transporter
TOPB45_RS03275	COG0483	inositol monophosphate 1-phosphatase activity
TOPB45_RS03290	COG0557	exoribonuclease II activity
TOPB45_RS03315	COG0402	S-adenosylhomocysteine deaminase activity
TOPB45_RS03320	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TOPB45_RS03325	COG1979	alcohol dehydrogenase
TOPB45_RS03330	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
TOPB45_RS03335	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
TOPB45_RS03350	COG1309	transcriptional regulator
TOPB45_RS03370	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
TOPB45_RS03380	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
TOPB45_RS03390	COG1620	l-lactate permease
TOPB45_RS03415	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
TOPB45_RS03420	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
TOPB45_RS03425	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TOPB45_RS03430	COG0477	Major facilitator Superfamily
TOPB45_RS03445	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
TOPB45_RS03455	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
TOPB45_RS03460	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
TOPB45_RS03470	COG2204	response regulator
TOPB45_RS03475	COG5002	protein histidine kinase activity
TOPB45_RS03490	COG1490	D-aminoacyl-tRNA deacylase activity
TOPB45_RS03510	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
TOPB45_RS03515	COG0509	glycine decarboxylation via glycine cleavage system
TOPB45_RS03520	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
TOPB45_RS03525	COG1980	fructose-bisphosphate aldolase activity
TOPB45_RS03545	COG0436	Aminotransferase
TOPB45_RS03560	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
TOPB45_RS03565	COG1674	ftsk spoiiie
TOPB45_RS03585	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
TOPB45_RS03590	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
TOPB45_RS03595	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
TOPB45_RS03605	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
TOPB45_RS03610	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
TOPB45_RS03610	COG0731	radical SAM domain protein
TOPB45_RS03620	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
TOPB45_RS03630	COG0019	diaminopimelate decarboxylase activity
TOPB45_RS03635	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
TOPB45_RS03645	COG0708	Exodeoxyribonuclease III
TOPB45_RS03665	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
TOPB45_RS03670	COG0228	four-way junction DNA binding
TOPB45_RS03675	COG1837	Belongs to the UPF0109 family
TOPB45_RS03680	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
TOPB45_RS03685	COG0336	Belongs to the RNA methyltransferase TrmD family
TOPB45_RS03685	COG4752	Belongs to the RNA methyltransferase TrmD family
TOPB45_RS03690	COG2608	mercury ion transmembrane transporter activity
TOPB45_RS03695	COG2217	Heavy metal translocating P-type atpase
TOPB45_RS03715	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
TOPB45_RS03720	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
TOPB45_RS03725	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
TOPB45_RS03730	COG0101	tRNA pseudouridine synthase activity
TOPB45_RS03735	COG0131	Imidazoleglycerol-phosphate dehydratase
TOPB45_RS03745	COG0215	cysteine-tRNA ligase activity
TOPB45_RS03750	COG2894	cell division
TOPB45_RS03755	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
TOPB45_RS03760	COG0527	aspartate kinase activity
TOPB45_RS03785	COG0531	amino acid
TOPB45_RS03810	COG1131	(ABC) transporter
TOPB45_RS03820	COG2078	PFAM AMMECR1 domain protein
TOPB45_RS03830	COG0778	Nitroreductase
TOPB45_RS03845	COG0484	heat shock protein binding
TOPB45_RS03850	COG2131	deaminase
TOPB45_RS03855	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
TOPB45_RS03860	COG0463	Glycosyl transferase, family 2
TOPB45_RS03875	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
TOPB45_RS03880	COG0049	tRNA binding
TOPB45_RS03885	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
TOPB45_RS03890	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
TOPB45_RS03895	COG0051	transcription antitermination factor activity, RNA binding
TOPB45_RS03900	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
TOPB45_RS03915	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
TOPB45_RS03920	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
TOPB45_RS03925	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
TOPB45_RS03930	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
TOPB45_RS03940	COG0255	Belongs to the universal ribosomal protein uL29 family
TOPB45_RS03945	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
TOPB45_RS03950	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
TOPB45_RS03955	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
TOPB45_RS03960	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
TOPB45_RS03965	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
TOPB45_RS03970	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
TOPB45_RS03975	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
TOPB45_RS03980	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
TOPB45_RS03985	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
TOPB45_RS03990	COG1841	ribosomal large subunit assembly
TOPB45_RS03995	COG0200	Binds to the 23S rRNA
TOPB45_RS04000	COG0201	protein transport
TOPB45_RS04005	COG0563	adenylate kinase activity
TOPB45_RS04015	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
TOPB45_RS04020	COG0257	Belongs to the bacterial ribosomal protein bL36 family
TOPB45_RS04025	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
TOPB45_RS04030	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
TOPB45_RS04035	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
TOPB45_RS04040	COG0202	RNA polymerase activity
TOPB45_RS04045	COG0203	ribosomal protein L17
TOPB45_RS04050	COG0617	tRNA 3'-terminal CCA addition
TOPB45_RS04055	COG0544	peptidyl-prolyl cis-trans isomerase activity
TOPB45_RS04060	COG0740	serine-type endopeptidase activity
TOPB45_RS04065	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
TOPB45_RS04070	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
TOPB45_RS04075	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
TOPB45_RS04085	COG1522	sequence-specific DNA binding
TOPB45_RS04090	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
TOPB45_RS04100	COG5000	phosphorelay sensor kinase activity
TOPB45_RS04105	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
TOPB45_RS04105	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
TOPB45_RS04110	COG0828	Belongs to the bacterial ribosomal protein bS21 family
TOPB45_RS04130	COG1522	sequence-specific DNA binding
TOPB45_RS04135	COG0730	response to heat
TOPB45_RS04140	COG0501	Belongs to the peptidase M48B family
TOPB45_RS04225	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TOPB45_RS04250	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
TOPB45_RS04260	COG2204	response regulator
TOPB45_RS04275	COG0010	Belongs to the arginase family
TOPB45_RS04305	COG4974	Belongs to the 'phage' integrase family
TOPB45_RS04310	COG0617	tRNA 3'-terminal CCA addition
TOPB45_RS04315	COG0539	negative regulation of cytoplasmic translation
TOPB45_RS04320	COG0616	signal peptide processing
TOPB45_RS04325	COG0776	regulation of translation
TOPB45_RS04330	COG0516	GMP reductase activity
TOPB45_RS04330	COG0517	IMP dehydrogenase activity
TOPB45_RS04335	COG1459	type II secretion system
TOPB45_RS04345	COG1968	undecaprenyl-diphosphatase activity
TOPB45_RS04355	COG2890	protein-(glutamine-N5) methyltransferase activity
TOPB45_RS04360	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
TOPB45_RS04390	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
TOPB45_RS04395	COG0811	peptide transport
TOPB45_RS04400	COG0848	biopolymer transport protein
TOPB45_RS04425	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
TOPB45_RS04435	COG1793	dna ligase
TOPB45_RS04485	COG0714	Associated with various cellular activities
TOPB45_RS04500	COG0750	zinc metalloprotease
TOPB45_RS04515	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
TOPB45_RS04535	COG0356	it plays a direct role in the translocation of protons across the membrane
TOPB45_RS04540	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
TOPB45_RS04550	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
TOPB45_RS04550	COG1213	nucleotidyl transferase
TOPB45_RS04565	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
TOPB45_RS04570	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
TOPB45_RS04580	COG0640	Transcriptional regulator
TOPB45_RS04605	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
TOPB45_RS04610	COG3852	Histidine kinase
TOPB45_RS04620	COG0437	4 iron, 4 sulfur cluster binding
TOPB45_RS04650	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
TOPB45_RS04655	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
TOPB45_RS04675	COG0473	3-isopropylmalate dehydrogenase activity
TOPB45_RS04680	COG0322	excinuclease ABC activity
TOPB45_RS04685	COG2197	response regulator
TOPB45_RS04720	COG1635	Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur
TOPB45_RS04725	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
TOPB45_RS04730	COG1459	type II secretion system
TOPB45_RS04735	COG3267	Type II secretory pathway component ExeA
TOPB45_RS04735	COG3409	Peptidoglycan-binding domain 1 protein
TOPB45_RS04775	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
TOPB45_RS04790	COG0497	DNA recombination
TOPB45_RS04795	COG3842	ATPase activity
TOPB45_RS04815	COG2001	Belongs to the MraZ family
TOPB45_RS04820	COG0275	rRNA processing
TOPB45_RS04835	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
TOPB45_RS04840	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
TOPB45_RS04845	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
TOPB45_RS04860	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
TOPB45_RS04865	COG0812	UDP-N-acetylmuramate dehydrogenase activity
TOPB45_RS04895	COG0135	phosphoribosylanthranilate isomerase activity
TOPB45_RS04915	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
TOPB45_RS04920	COG0167	dihydroorotate dehydrogenase activity
TOPB45_RS04925	COG0543	2 iron, 2 sulfur cluster binding
TOPB45_RS04940	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
TOPB45_RS04940	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
TOPB45_RS04955	COG0463	Glycosyl transferase, family 2
TOPB45_RS04995	COG5002	protein histidine kinase activity
TOPB45_RS05000	COG2204	response regulator
TOPB45_RS05015	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TOPB45_RS05025	COG0430	RNA-3'-phosphate cyclase activity
TOPB45_RS05040	COG1648	precorrin-2 dehydrogenase activity
TOPB45_RS05040	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
TOPB45_RS05045	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
TOPB45_RS05050	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
TOPB45_RS05060	COG0335	large ribosomal subunit rRNA binding
TOPB45_RS05065	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
TOPB45_RS05070	COG0792	nuclease activity
TOPB45_RS05085	COG0460	homoserine dehydrogenase
TOPB45_RS05125	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
TOPB45_RS05130	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
TOPB45_RS05135	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
TOPB45_RS05145	COG0758	DNA mediated transformation
TOPB45_RS05150	COG2814	Major facilitator Superfamily
TOPB45_RS05155	COG0151	Belongs to the GarS family
TOPB45_RS05160	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
TOPB45_RS05165	COG0425	Belongs to the sulfur carrier protein TusA family
TOPB45_RS05165	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
TOPB45_RS05175	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
TOPB45_RS05195	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
TOPB45_RS05200	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
TOPB45_RS05205	COG0542	response to heat
TOPB45_RS05215	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
TOPB45_RS05220	COG0105	UTP biosynthetic process
TOPB45_RS05230	COG1994	Peptidase M50
TOPB45_RS05235	COG0793	Belongs to the peptidase S41A family
TOPB45_RS05240	COG0052	Belongs to the universal ribosomal protein uS2 family
TOPB45_RS05245	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
TOPB45_RS05250	COG0528	UMP kinase activity
TOPB45_RS05255	COG0233	cytoplasmic translational termination
TOPB45_RS05275	COG1181	Belongs to the D-alanine--D-alanine ligase family
TOPB45_RS05285	COG2823	Periplasmic or secreted lipoprotein
TOPB45_RS05290	COG1242	4 iron, 4 sulfur cluster binding
TOPB45_RS05310	COG0445	tRNA wobble uridine modification
TOPB45_RS05330	COG0210	DNA helicase
TOPB45_RS05345	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
TOPB45_RS05350	COG0525	valine-tRNA ligase activity
TOPB45_RS05360	COG1196	nuclear chromosome segregation
TOPB45_RS05390	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
TOPB45_RS05405	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
TOPB45_RS05485	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
TOPB45_RS05510	COG0577	efflux transmembrane transporter activity
TOPB45_RS05510	COG1136	(ABC) transporter
TOPB45_RS05515	COG0577	efflux transmembrane transporter activity
TOPB45_RS05515	COG1136	(ABC) transporter
TOPB45_RS05520	COG0577	efflux transmembrane transporter activity
TOPB45_RS05520	COG1136	(ABC) transporter
TOPB45_RS05525	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
TOPB45_RS05535	COG0531	amino acid
TOPB45_RS05540	COG2095	MarC family integral membrane protein
TOPB45_RS05550	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
TOPB45_RS05560	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
TOPB45_RS05570	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
TOPB45_RS05575	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
TOPB45_RS05580	COG1355	regulation of microtubule-based process
TOPB45_RS05585	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
TOPB45_RS05595	COG5001	Diguanylate cyclase
TOPB45_RS05595	COG5002	protein histidine kinase activity
TOPB45_RS05690	COG4637	Psort location Cytoplasmic, score
TOPB45_RS05730	COG1353	crispr-associated protein
TOPB45_RS05740	COG1337	RAMP superfamily
TOPB45_RS05775	COG1518	maintenance of DNA repeat elements
TOPB45_RS05795	COG2149	membrane
TOPB45_RS05800	COG1187	pseudouridine synthase activity
TOPB45_RS05805	COG3158	transport of potassium into the cell
TOPB45_RS05840	COG0180	Tryptophanyl-tRNA synthetase
TOPB45_RS05845	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
TOPB45_RS05850	COG1333	cytochrome c biogenesis protein
TOPB45_RS05870	COG0481	GTPase activity
TOPB45_RS05890	COG0037	tRNA processing
TOPB45_RS05900	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
TOPB45_RS05910	COG1187	pseudouridine synthase activity
TOPB45_RS05915	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
TOPB45_RS05925	COG0220	tRNA (guanine-N7-)-methyltransferase activity
TOPB45_RS05925	COG1519	Transferase
TOPB45_RS05930	COG1496	oxidoreductase activity
TOPB45_RS05935	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
TOPB45_RS05950	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
TOPB45_RS05960	COG0557	exoribonuclease II activity
TOPB45_RS05970	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
TOPB45_RS05975	COG0719	Fe-S assembly protein
TOPB45_RS05995	COG1185	polyribonucleotide nucleotidyltransferase activity
TOPB45_RS06010	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
TOPB45_RS06015	COG0859	PFAM glycosyl transferase family 9
TOPB45_RS06020	COG1132	(ABC) transporter
TOPB45_RS06025	COG0501	Belongs to the peptidase M48B family
TOPB45_RS06035	COG0688	phosphatidylethanolamine metabolic process
TOPB45_RS06040	COG1183	phosphatidylcholine synthase activity
TOPB45_RS06045	COG2052	Domain of unknown function (DUF370)
TOPB45_RS06050	COG0194	GDP metabolic process
TOPB45_RS06055	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
TOPB45_RS06100	COG1918	ferrous iron import across plasma membrane
TOPB45_RS06105	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
TOPB45_RS06105	COG1918	ferrous iron import across plasma membrane
TOPB45_RS06115	COG0537	adenosine 5'-monophosphoramidase activity
TOPB45_RS06120	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TOPB45_RS06120	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TOPB45_RS06125	COG1774	PSP1 C-terminal conserved region
TOPB45_RS06130	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
TOPB45_RS06140	COG2835	tetraacyldisaccharide 4'-kinase activity
TOPB45_RS06150	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
TOPB45_RS06165	COG3437	response regulator, receiver
TOPB45_RS06165	COG0784	Response regulator, receiver
TOPB45_RS06180	COG5001	Diguanylate cyclase
TOPB45_RS06180	COG3300	MHYT domain
TOPB45_RS06185	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
TOPB45_RS06190	COG0284	orotidine-5'-phosphate decarboxylase activity
TOPB45_RS06220	COG0437	4 iron, 4 sulfur cluster binding
TOPB45_RS06230	COG1797	cobyrinic acid a,c-diamide synthase activity
TOPB45_RS06240	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
TOPB45_RS06270	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
TOPB45_RS06275	COG1862	Preprotein translocase
TOPB45_RS06280	COG0343	queuine tRNA-ribosyltransferase activity
TOPB45_RS06285	COG0436	Aminotransferase
TOPB45_RS06300	COG0456	acetyltransferase
TOPB45_RS06300	COG1846	Transcriptional regulator
TOPB45_RS06340	COG1518	maintenance of DNA repeat elements
TOPB45_RS06345	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
TOPB45_RS06365	COG3328	transposase activity
TOPB45_RS06410	COG0425	Belongs to the sulfur carrier protein TusA family
TOPB45_RS06420	COG0589	response to stress
TOPB45_RS06465	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
TOPB45_RS06470	COG0428	transporter
TOPB45_RS06485	COG0070	glutamate synthase
TOPB45_RS06485	COG0067	glutamate synthase
TOPB45_RS06485	COG0069	glutamate synthase activity
TOPB45_RS06490	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
TOPB45_RS06495	COG0174	glutamine synthetase
TOPB45_RS06510	COG0347	Belongs to the P(II) protein family
TOPB45_RS06520	COG2067	long-chain fatty acid transport protein
TOPB45_RS06530	COG1141	Ferredoxin
TOPB45_RS06540	COG0489	protein tyrosine kinase activity
TOPB45_RS06545	COG1702	phosphate starvation-inducible protein PhoH
TOPB45_RS06555	COG1872	DUF167
TOPB45_RS06560	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
TOPB45_RS06560	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
TOPB45_RS06565	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
TOPB45_RS06570	COG0439	Biotin carboxylase
TOPB45_RS06575	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
TOPB45_RS06585	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
TOPB45_RS06585	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
TOPB45_RS06590	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
TOPB45_RS06600	COG2884	Cell division ATP-binding protein ftsE
TOPB45_RS06620	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
TOPB45_RS06625	COG0752	glycyl-tRNA synthetase alpha subunit
TOPB45_RS06630	COG0751	glycine-tRNA ligase activity
TOPB45_RS06640	COG1067	ATP-dependent peptidase activity
TOPB45_RS06645	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
TOPB45_RS06650	COG0066	3-isopropylmalate dehydratase activity
TOPB45_RS06655	COG3956	TIGRFAM MazG family protein
TOPB45_RS06660	COG1121	(ABC) transporter
TOPB45_RS06665	COG1108	ABC-type Mn2 Zn2 transport systems permease components
TOPB45_RS06670	COG0084	hydrolase, TatD family'
TOPB45_RS06675	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
TOPB45_RS06685	COG1573	uracil-dna glycosylase
TOPB45_RS06690	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
TOPB45_RS06695	COG2086	electron transfer activity
TOPB45_RS06700	COG1960	acyl-CoA dehydrogenase activity
TOPB45_RS06705	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
TOPB45_RS06710	COG0318	PFAM AMP-dependent synthetase and ligase
TOPB45_RS06725	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
TOPB45_RS06730	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
TOPB45_RS06745	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
TOPB45_RS06750	COG1528	Iron-storage protein
TOPB45_RS06760	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
TOPB45_RS06765	COG0310	cobalt ion transport
TOPB45_RS06770	COG0310	cobalt ion transport
TOPB45_RS06800	COG0484	heat shock protein binding
TOPB45_RS06810	COG2201	protein-glutamate methylesterase activity
TOPB45_RS06815	COG0745	RESPONSE REGULATOR receiver
TOPB45_RS06840	COG1191	sigma factor activity
TOPB45_RS06850	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
TOPB45_RS06855	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
TOPB45_RS06860	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
TOPB45_RS06870	COG1987	bacterial-type flagellum assembly
TOPB45_RS06875	COG1338	Plays a role in the flagellum-specific transport system
TOPB45_RS06905	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
TOPB45_RS06930	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
TOPB45_RS06955	COG0602	queuosine metabolic process
TOPB45_RS06975	COG1253	flavin adenine dinucleotide binding
TOPB45_RS06980	COG1253	flavin adenine dinucleotide binding
TOPB45_RS06995	COG0210	DNA helicase
TOPB45_RS07010	COG0261	This protein binds to 23S rRNA in the presence of protein L20
TOPB45_RS07015	COG0211	Belongs to the bacterial ribosomal protein bL27 family
TOPB45_RS07020	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
TOPB45_RS07035	COG0037	tRNA processing
TOPB45_RS07040	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
TOPB45_RS07045	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
TOPB45_RS07060	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
TOPB45_RS07090	COG1489	DNA binding
TOPB45_RS07095	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
TOPB45_RS07115	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
TOPB45_RS07125	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
TOPB45_RS07130	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
TOPB45_RS07135	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
TOPB45_RS07140	COG0574	Belongs to the PEP-utilizing enzyme family
TOPB45_RS07140	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
TOPB45_RS07145	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
TOPB45_RS07150	COG0456	acetyltransferase
TOPB45_RS07155	COG1660	Displays ATPase and GTPase activities
TOPB45_RS07170	COG1137	ATPase activity
TOPB45_RS07180	COG0459	protein refolding
TOPB45_RS07185	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
TOPB45_RS07195	COG0330	HflC and HflK could
TOPB45_RS07205	COG0028	Belongs to the TPP enzyme family
TOPB45_RS07210	COG0440	acetolactate synthase activity
TOPB45_RS07215	COG3959	Transketolase, thiamine diphosphate binding domain
TOPB45_RS07220	COG0805	protein transport
TOPB45_RS07225	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
TOPB45_RS07230	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
TOPB45_RS07245	COG2221	Nitrite and sulphite reductase 4Fe-4S
TOPB45_RS07250	COG2221	Nitrite and sulphite reductase 4Fe-4S
TOPB45_RS07255	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
TOPB45_RS07260	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
TOPB45_RS07265	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
TOPB45_RS07275	COG0227	Belongs to the bacterial ribosomal protein bL28 family
TOPB45_RS07285	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
TOPB45_RS07295	COG1722	exodeoxyribonuclease VII activity
TOPB45_RS07300	COG1570	exodeoxyribonuclease VII activity
TOPB45_RS07325	COG0489	protein tyrosine kinase activity
TOPB45_RS07345	COG1959	2 iron, 2 sulfur cluster binding
TOPB45_RS07350	COG1294	oxidase, subunit
TOPB45_RS07355	COG1271	oxidase subunit
TOPB45_RS07370	COG1458	PINc domain ribonuclease
TOPB45_RS07380	COG0495	leucyl-tRNA aminoacylation
TOPB45_RS07385	COG0538	isocitrate dehydrogenase activity
TOPB45_RS07390	COG1573	uracil-dna glycosylase
TOPB45_RS07395	COG1030	water channel activity
TOPB45_RS07405	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
TOPB45_RS07415	COG1362	aminopeptidase activity
TOPB45_RS07430	COG0268	Binds directly to 16S ribosomal RNA
TOPB45_RS07440	COG0521	Mo-molybdopterin cofactor biosynthetic process
TOPB45_RS07450	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
TOPB45_RS07470	COG0437	4 iron, 4 sulfur cluster binding
TOPB45_RS07480	COG1663	tetraacyldisaccharide 4'-kinase activity
TOPB45_RS07495	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
TOPB45_RS07505	COG0181	hydroxymethylbilane synthase activity
TOPB45_RS07515	COG0247	lactate metabolic process
TOPB45_RS07525	COG1253	flavin adenine dinucleotide binding
TOPB45_RS07530	COG0815	Transfers the fatty acyl group on membrane lipoproteins
TOPB45_RS07535	COG0163	prenyltransferase activity
TOPB45_RS07565	COG0835	chemotaxis
TOPB45_RS07570	COG0784	Response regulator, receiver
TOPB45_RS07570	COG2198	Histidine kinase
TOPB45_RS07570	COG0643	Histidine kinase
TOPB45_RS07575	COG1619	proteins homologs of microcin C7 resistance protein MccF
TOPB45_RS07580	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
TOPB45_RS07585	COG2264	protein methyltransferase activity
TOPB45_RS07605	COG1605	Chorismate mutase
TOPB45_RS07605	COG0077	Prephenate dehydratase
TOPB45_RS07615	COG0195	Participates in both transcription termination and antitermination
TOPB45_RS07620	COG0779	Required for maturation of 30S ribosomal subunits
TOPB45_RS07625	COG0477	Major facilitator Superfamily
TOPB45_RS07630	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
TOPB45_RS07635	COG1966	Carbon starvation protein
TOPB45_RS07645	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
TOPB45_RS07650	COG0592	DNA-directed DNA polymerase activity
TOPB45_RS07655	COG0187	DNA topoisomerase II activity
TOPB45_RS07660	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
TOPB45_RS07665	COG5557	Pfam Polysulphide reductase, NrfD
TOPB45_RS07670	COG3064	Membrane
TOPB45_RS07670	COG0437	4 iron, 4 sulfur cluster binding
TOPB45_RS07675	COG0484	heat shock protein binding
TOPB45_RS07695	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
TOPB45_RS07700	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
TOPB45_RS07700	COG1796	DNA polymerase
TOPB45_RS07705	COG1686	Belongs to the peptidase S11 family
TOPB45_RS07710	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
TOPB45_RS07715	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TOPB45_RS07720	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
TOPB45_RS07725	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
TOPB45_RS07730	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
TOPB45_RS07745	COG0535	radical SAM domain protein
TOPB45_RS07755	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
TOPB45_RS07760	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
TOPB45_RS07795	COG0482	sulfurtransferase activity
TOPB45_RS07800	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
TOPB45_RS07805	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
TOPB45_RS07810	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
TOPB45_RS07825	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
TOPB45_RS07845	COG2920	part of a sulfur-relay system
TOPB45_RS07860	COG0018	arginyl-trna synthetase
TOPB45_RS07870	COG0564	pseudouridine synthase activity
TOPB45_RS07880	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
TOPB45_RS07885	COG0443	Heat shock 70 kDa protein
TOPB45_RS07890	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
TOPB45_RS07895	COG0157	Belongs to the NadC ModD family
TOPB45_RS07900	COG1227	inorganic diphosphatase activity
TOPB45_RS07920	COG1160	GTP binding
TOPB45_RS07935	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
TOPB45_RS07945	COG0355	proton-transporting ATP synthase activity, rotational mechanism
TOPB45_RS07950	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
TOPB45_RS07955	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
TOPB45_RS07960	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
TOPB45_RS07965	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
TOPB45_RS07980	COG0772	Belongs to the SEDS family
TOPB45_RS07985	COG0768	penicillin binding
TOPB45_RS08010	COG1234	tRNA 3'-trailer cleavage
TOPB45_RS08025	COG0436	Aminotransferase
TOPB45_RS08030	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
TOPB45_RS08060	COG1706	bacterial-type flagellum-dependent cell motility
TOPB45_RS08065	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
TOPB45_RS08080	COG4786	Flagellar basal body rod
TOPB45_RS08085	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
TOPB45_RS08100	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
TOPB45_RS08120	COG1278	Cold shock
TOPB45_RS08130	COG1892	Catalyzes the irreversible beta-carboxylation of phosphoenolpyruvate (PEP) to form oxaloacetate (OAA), a four- carbon dicarboxylic acid source for the tricarboxylic acid cycle
TOPB45_RS08135	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
TOPB45_RS08140	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
TOPB45_RS08165	COG0504	CTP synthase activity
TOPB45_RS08175	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
TOPB45_RS08190	COG1418	mRNA catabolic process
TOPB45_RS08195	COG1692	metallophosphoesterase
TOPB45_RS08200	COG0242	peptide deformylase activity
TOPB45_RS08205	COG1028	Short-chain dehydrogenase reductase Sdr
TOPB45_RS08210	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
TOPB45_RS08220	COG0674	pyruvate-flavodoxin oxidoreductase activity
TOPB45_RS08225	COG1013	pyruvate-flavodoxin oxidoreductase activity
TOPB45_RS08235	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
TOPB45_RS08255	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
TOPB45_RS08265	COG0735	belongs to the Fur family
TOPB45_RS08275	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
TOPB45_RS08285	COG0009	L-threonylcarbamoyladenylate synthase
TOPB45_RS08305	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
TOPB45_RS08310	COG0805	protein transport
TOPB45_RS08315	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
TOPB45_RS08320	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
TOPB45_RS08325	COG0492	ferredoxin-NADP+ reductase activity
TOPB45_RS08340	COG0165	Argininosuccinate lyase
TOPB45_RS08365	COG1959	2 iron, 2 sulfur cluster binding
TOPB45_RS08370	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
TOPB45_RS08375	COG1525	nuclease
TOPB45_RS08385	COG1516	flagellar protein fliS
TOPB45_RS08400	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
TOPB45_RS08410	COG0444	Belongs to the ABC transporter superfamily
TOPB45_RS08415	COG4608	Belongs to the ABC transporter superfamily
TOPB45_RS08450	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
TOPB45_RS08460	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
TOPB45_RS08505	COG0860	N-Acetylmuramoyl-L-alanine amidase
TOPB45_RS08515	COG3706	GGDEF domain
TOPB45_RS08520	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
TOPB45_RS08530	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
TOPB45_RS08540	COG0671	phosphoesterase, PA-phosphatase related
TOPB45_RS08545	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
TOPB45_RS08555	COG0358	DNA primase activity
TOPB45_RS08565	COG1434	Gram-negative-bacterium-type cell wall biogenesis
TOPB45_RS08570	COG0470	DNA polymerase III
TOPB45_RS08590	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
TOPB45_RS08595	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
TOPB45_RS08620	COG4589	Belongs to the CDS family
TOPB45_RS08630	COG2199	diguanylate cyclase activity
TOPB45_RS08630	COG2203	Gaf domain
TOPB45_RS08655	COG0328	RNA-DNA hybrid ribonuclease activity
TOPB45_RS08670	COG0247	lactate metabolic process
TOPB45_RS08685	COG1555	photosystem II stabilization
TOPB45_RS08685	COG1596	polysaccharide export
TOPB45_RS08695	COG1792	Involved in formation and maintenance of cell shape