locus-tag	class	description
F1847_RS00005	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
F1847_RS00020	COG0539	negative regulation of cytoplasmic translation
F1847_RS00025	COG0616	signal peptide processing
F1847_RS00035	COG0516	GMP reductase activity
F1847_RS00035	COG0517	IMP dehydrogenase activity
F1847_RS00040	COG1459	type II secretion system
F1847_RS00055	COG2890	protein-(glutamine-N5) methyltransferase activity
F1847_RS00060	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
F1847_RS00065	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
F1847_RS00090	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
F1847_RS00095	COG0312	modulator of DNA gyrase
F1847_RS00100	COG0148	phosphopyruvate hydratase activity
F1847_RS00105	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
F1847_RS00105	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
F1847_RS00110	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
F1847_RS00120	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
F1847_RS00130	COG0732	type I restriction modification DNA specificity domain
F1847_RS00175	COG1515	deoxyribonuclease V activity
F1847_RS00195	COG0629	single-stranded DNA binding
F1847_RS00200	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
F1847_RS00205	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
F1847_RS00215	COG0842	Transport permease protein
F1847_RS00220	COG0842	Transport permease protein
F1847_RS00225	COG1131	(ABC) transporter
F1847_RS00230	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
F1847_RS00235	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
F1847_RS00245	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
F1847_RS00250	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
F1847_RS00255	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
F1847_RS00265	COG3876	Protein conserved in bacteria
F1847_RS00275	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
F1847_RS00285	COG0492	ferredoxin-NADP+ reductase activity
F1847_RS00295	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
F1847_RS00295	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
F1847_RS00300	COG0232	Belongs to the dGTPase family. Type 2 subfamily
F1847_RS00315	COG0589	response to stress
F1847_RS00320	COG1151	hydroxylamine reductase activity
F1847_RS00370	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
F1847_RS00380	COG0475	glutathione-regulated potassium exporter activity
F1847_RS00380	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
F1847_RS00385	COG0475	glutathione-regulated potassium exporter activity
F1847_RS00390	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
F1847_RS00400	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
F1847_RS00410	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
F1847_RS00415	COG0489	protein tyrosine kinase activity
F1847_RS00430	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
F1847_RS00435	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
F1847_RS00440	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
F1847_RS00450	COG0303	'Molybdopterin
F1847_RS00465	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
F1847_RS00470	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
F1847_RS00475	COG1408	metallophosphoesterase
F1847_RS00480	COG0535	radical SAM domain protein
F1847_RS00485	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
F1847_RS00495	COG0730	response to heat
F1847_RS00520	COG0438	transferase activity, transferring glycosyl groups
F1847_RS00520	COG1216	Glycosyl transferase, family 2
F1847_RS00550	COG0529	Catalyzes the synthesis of activated sulfate
F1847_RS00585	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
F1847_RS00605	COG1091	dTDP-4-dehydrorhamnose reductase activity
F1847_RS00650	COG0859	PFAM glycosyl transferase family 9
F1847_RS00655	COG0585	pseudouridine synthase activity
F1847_RS00660	COG0653	protein targeting
F1847_RS00675	COG3118	belongs to the thioredoxin family
F1847_RS00710	COG0746	molybdenum cofactor guanylyltransferase activity
F1847_RS00720	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
F1847_RS00725	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
F1847_RS00725	COG0574	Belongs to the PEP-utilizing enzyme family
F1847_RS00740	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
F1847_RS00745	COG0126	phosphoglycerate kinase activity
F1847_RS00745	COG0149	triose-phosphate isomerase activity
F1847_RS00750	COG0126	phosphoglycerate kinase activity
F1847_RS00750	COG0149	triose-phosphate isomerase activity
F1847_RS00755	COG1832	CoA-binding protein
F1847_RS00765	COG0437	4 iron, 4 sulfur cluster binding
F1847_RS00775	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
F1847_RS00780	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
F1847_RS00785	COG0649	NAD binding
F1847_RS00790	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
F1847_RS00795	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
F1847_RS00800	COG0839	Belongs to the complex I subunit 6 family
F1847_RS00805	COG0713	ATP synthesis coupled electron transport
F1847_RS00820	COG1007	ATP synthesis coupled electron transport
F1847_RS00840	COG1749	Flagellar hook protein flgE
F1847_RS00845	COG1592	Rubrerythrin
F1847_RS00860	COG0450	alkyl hydroperoxide reductase
F1847_RS00875	COG2199	diguanylate cyclase activity
F1847_RS00875	COG2203	Gaf domain
F1847_RS00885	COG1918	ferrous iron import across plasma membrane
F1847_RS00890	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
F1847_RS00890	COG1918	ferrous iron import across plasma membrane
F1847_RS00900	COG0708	Exodeoxyribonuclease III
F1847_RS00915	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
F1847_RS00920	COG2255	four-way junction helicase activity
F1847_RS00930	COG0291	Belongs to the bacterial ribosomal protein bL35 family
F1847_RS00935	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
F1847_RS00940	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
F1847_RS00945	COG0072	phenylalanine-tRNA ligase activity
F1847_RS00960	COG2033	superoxide reductase activity
F1847_RS00965	COG1773	rubredoxin
F1847_RS00975	COG1773	rubredoxin
F1847_RS00985	COG0426	domain, Protein
F1847_RS00995	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
F1847_RS01000	COG0505	Belongs to the CarA family
F1847_RS01005	COG0196	riboflavin kinase activity
F1847_RS01020	COG0123	including yeast histone deacetylase and acetoin utilization protein
F1847_RS01025	COG0564	pseudouridine synthase activity
F1847_RS01030	COG0237	dephospho-CoA kinase activity
F1847_RS01035	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
F1847_RS01035	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
F1847_RS01050	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
F1847_RS01050	COG1773	rubredoxin
F1847_RS01060	COG0217	transcriptional regulatory protein
F1847_RS01070	COG0632	four-way junction helicase activity
F1847_RS01100	COG2223	nitrite transmembrane transporter activity
F1847_RS01130	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
F1847_RS01140	COG0432	Pfam Uncharacterised protein family UPF0047
F1847_RS01145	COG1028	Short-chain dehydrogenase reductase Sdr
F1847_RS01160	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
F1847_RS01165	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
F1847_RS01200	COG2884	Cell division ATP-binding protein ftsE
F1847_RS01210	COG2221	Nitrite and sulphite reductase 4Fe-4S
F1847_RS01215	COG2221	Nitrite and sulphite reductase 4Fe-4S
F1847_RS01225	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
F1847_RS01230	COG0805	protein transport
F1847_RS01235	COG3959	Transketolase, thiamine diphosphate binding domain
F1847_RS01240	COG0440	acetolactate synthase activity
F1847_RS01245	COG0028	Belongs to the TPP enzyme family
F1847_RS01255	COG0330	HflC and HflK could
F1847_RS01260	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
F1847_RS01265	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
F1847_RS01270	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
F1847_RS01280	COG0131	Imidazoleglycerol-phosphate dehydratase
F1847_RS01290	COG0215	cysteine-tRNA ligase activity
F1847_RS01295	COG0455	bacterial-type flagellum organization
F1847_RS01300	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
F1847_RS01305	COG0527	aspartate kinase activity
F1847_RS01310	COG0484	heat shock protein binding
F1847_RS01320	COG2078	PFAM AMMECR1 domain protein
F1847_RS01325	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
F1847_RS01330	COG0778	Nitroreductase
F1847_RS01345	COG0484	heat shock protein binding
F1847_RS01350	COG2131	deaminase
F1847_RS01355	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
F1847_RS01360	COG0463	Glycosyl transferase, family 2
F1847_RS01380	COG0673	inositol 2-dehydrogenase activity
F1847_RS01390	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
F1847_RS01395	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
F1847_RS01400	COG0049	tRNA binding
F1847_RS01405	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
F1847_RS01410	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
F1847_RS01415	COG0051	transcription antitermination factor activity, RNA binding
F1847_RS01420	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
F1847_RS01425	COG0088	Forms part of the polypeptide exit tunnel
F1847_RS01435	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
F1847_RS01440	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
F1847_RS01445	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
F1847_RS01450	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
F1847_RS01460	COG0255	Belongs to the universal ribosomal protein uL29 family
F1847_RS01465	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
F1847_RS01475	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
F1847_RS01480	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
F1847_RS01485	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
F1847_RS01490	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
F1847_RS01495	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
F1847_RS01500	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
F1847_RS01505	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
F1847_RS01510	COG1841	ribosomal large subunit assembly
F1847_RS01515	COG0200	Binds to the 23S rRNA
F1847_RS01520	COG0201	protein transport
F1847_RS01525	COG0563	adenylate kinase activity
F1847_RS01535	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
F1847_RS01540	COG0257	Belongs to the bacterial ribosomal protein bL36 family
F1847_RS01550	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
F1847_RS01555	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
F1847_RS01560	COG0202	RNA polymerase activity
F1847_RS01565	COG0203	ribosomal protein L17
F1847_RS01570	COG0617	tRNA 3'-terminal CCA addition
F1847_RS01575	COG0544	peptidyl-prolyl cis-trans isomerase activity
F1847_RS01580	COG0740	serine-type endopeptidase activity
F1847_RS01585	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
F1847_RS01590	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
F1847_RS01595	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
F1847_RS01615	COG2203	Gaf domain
F1847_RS01615	COG4251	negative regulation of phosphorylation
F1847_RS01615	COG5001	Diguanylate cyclase
F1847_RS01615	COG3706	GGDEF domain
F1847_RS01620	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
F1847_RS01625	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
F1847_RS01635	COG2252	PERMEase
F1847_RS01645	COG0039	L-malate dehydrogenase activity
F1847_RS01650	COG4956	integral membrane protein (PIN domain superfamily)
F1847_RS01655	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
F1847_RS01660	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
F1847_RS01670	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
F1847_RS01675	COG1192	Involved in chromosome partitioning
F1847_RS01680	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
F1847_RS01685	COG0298	carbon dioxide binding
F1847_RS01695	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
F1847_RS01700	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
F1847_RS01715	COG1674	ftsk spoiiie
F1847_RS01725	COG0586	Pfam SNARE associated Golgi protein
F1847_RS01735	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
F1847_RS01740	COG0601	transmembrane transport
F1847_RS01745	COG1214	PFAM Peptidase M22, glycoprotease
F1847_RS01750	COG0750	zinc metalloprotease
F1847_RS01755	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
F1847_RS01770	COG0517	IMP dehydrogenase activity
F1847_RS01775	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
F1847_RS01775	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
F1847_RS01780	COG1187	pseudouridine synthase activity
F1847_RS01795	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
F1847_RS01815	COG0315	cyclic pyranopterin monophosphate synthase activity
F1847_RS01820	COG0484	heat shock protein binding
F1847_RS01825	COG1758	RNA polymerase activity
F1847_RS01830	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
F1847_RS01835	COG0129	dihydroxy-acid dehydratase activity
F1847_RS01840	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
F1847_RS01845	COG1127	ABC transporter
F1847_RS01860	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
F1847_RS01865	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
F1847_RS01870	COG3494	Protein of unknown function (DUF1009)
F1847_RS01875	COG0673	inositol 2-dehydrogenase activity
F1847_RS01880	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
F1847_RS01885	COG0138	bifunctional purine biosynthesis protein purh
F1847_RS01890	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
F1847_RS01895	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
F1847_RS01900	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
F1847_RS01905	COG0820	rRNA (adenine-C2-)-methyltransferase activity
F1847_RS01915	COG0165	Argininosuccinate lyase
F1847_RS01930	COG0492	ferredoxin-NADP+ reductase activity
F1847_RS01935	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
F1847_RS01950	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
F1847_RS01955	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
F1847_RS01975	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
F1847_RS01985	COG0805	protein transport
F1847_RS01990	COG0047	phosphoribosylformylglycinamidine synthase activity
F1847_RS02010	COG0628	permease
F1847_RS02025	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
F1847_RS02030	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
F1847_RS02035	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
F1847_RS02040	COG0193	aminoacyl-tRNA hydrolase activity
F1847_RS02050	COG0519	Catalyzes the synthesis of GMP from XMP
F1847_RS02065	COG0333	Belongs to the bacterial ribosomal protein bL32 family
F1847_RS02070	COG0416	fatty acid biosynthetic process
F1847_RS02075	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
F1847_RS02100	COG1704	LemA family
F1847_RS02120	COG1362	aminopeptidase activity
F1847_RS02130	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
F1847_RS02140	COG1030	water channel activity
F1847_RS02155	COG0751	glycine-tRNA ligase activity
F1847_RS02160	COG0752	glycyl-tRNA synthetase alpha subunit
F1847_RS02165	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
F1847_RS02180	COG0668	transmembrane transport
F1847_RS02190	COG0688	phosphatidylethanolamine metabolic process
F1847_RS02195	COG1183	phosphatidylcholine synthase activity
F1847_RS02200	COG2052	Domain of unknown function (DUF370)
F1847_RS02205	COG0194	GDP metabolic process
F1847_RS02210	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
F1847_RS02230	COG2105	PFAM AIG2 family protein
F1847_RS02235	COG2255	four-way junction helicase activity
F1847_RS02255	COG2204	response regulator
F1847_RS02260	COG1815	bacterial-type flagellum-dependent cell motility
F1847_RS02270	COG1677	Flagellar hook-basal body complex protein FliE
F1847_RS02275	COG1766	The M ring may be actively involved in energy transduction
F1847_RS02280	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
F1847_RS02290	COG1157	protein secretion by the type III secretion system
F1847_RS02305	COG3706	GGDEF domain
F1847_RS02310	COG0784	Response regulator, receiver
F1847_RS02310	COG2205	protein histidine kinase activity
F1847_RS02310	COG5002	protein histidine kinase activity
F1847_RS02320	COG3437	response regulator, receiver
F1847_RS02325	COG0735	belongs to the Fur family
F1847_RS02335	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
F1847_RS02365	COG0489	protein tyrosine kinase activity
F1847_RS02375	COG2226	methyltransferase
F1847_RS02380	COG0489	protein tyrosine kinase activity
F1847_RS02410	COG2226	methyltransferase
F1847_RS02420	COG3275	phosphorelay sensor kinase activity
F1847_RS02430	COG1716	ATPase activity
F1847_RS02430	COG5001	Diguanylate cyclase
F1847_RS02435	COG0415	Belongs to the DNA photolyase family
F1847_RS02440	COG2001	Belongs to the MraZ family
F1847_RS02445	COG0275	rRNA processing
F1847_RS02460	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
F1847_RS02465	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
F1847_RS02470	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
F1847_RS02480	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
F1847_RS02485	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
F1847_RS02505	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
F1847_RS02520	COG0135	phosphoribosylanthranilate isomerase activity
F1847_RS02540	COG2084	Dehydrogenase
F1847_RS02545	COG0307	riboflavin synthase, alpha
F1847_RS02550	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
F1847_RS02555	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
F1847_RS02560	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
F1847_RS02570	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
F1847_RS02575	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
F1847_RS02585	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
F1847_RS02590	COG1216	Glycosyl transferase, family 2
F1847_RS02595	COG3852	Histidine kinase
F1847_RS02600	COG2204	response regulator
F1847_RS02610	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
F1847_RS02620	COG0430	RNA-3'-phosphate cyclase activity
F1847_RS02640	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
F1847_RS02650	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
F1847_RS02655	COG0459	protein refolding
F1847_RS02665	COG0151	Belongs to the GarS family
F1847_RS02670	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
F1847_RS02695	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
F1847_RS02695	COG0731	radical SAM domain protein
F1847_RS02700	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
F1847_RS02710	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
F1847_RS02720	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
F1847_RS02725	COG0528	UMP kinase activity
F1847_RS02730	COG0233	cytoplasmic translational termination
F1847_RS02735	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
F1847_RS02740	COG4589	Belongs to the CDS family
F1847_RS02750	COG1181	Belongs to the D-alanine--D-alanine ligase family
F1847_RS02760	COG2823	Periplasmic or secreted lipoprotein
F1847_RS02765	COG1242	4 iron, 4 sulfur cluster binding
F1847_RS02775	COG1722	exodeoxyribonuclease VII activity
F1847_RS02780	COG0142	geranyltranstransferase activity
F1847_RS02785	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
F1847_RS02795	COG0227	Belongs to the bacterial ribosomal protein bL28 family
F1847_RS02810	COG3328	transposase activity
F1847_RS02825	COG1702	phosphate starvation-inducible protein PhoH
F1847_RS02835	COG1872	DUF167
F1847_RS02840	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
F1847_RS02845	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
F1847_RS02845	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
F1847_RS02850	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
F1847_RS02855	COG0284	orotidine-5'-phosphate decarboxylase activity
F1847_RS02880	COG1663	tetraacyldisaccharide 4'-kinase activity
F1847_RS02885	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
F1847_RS02890	COG0778	Nitroreductase
F1847_RS02955	COG3328	transposase activity
F1847_RS03000	COG4771	TonB-dependent receptor
F1847_RS03005	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
F1847_RS03010	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
F1847_RS03015	COG1120	ATPase activity
F1847_RS03025	COG1240	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
F1847_RS03025	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
F1847_RS03030	COG1131	(ABC) transporter
F1847_RS03045	COG1994	Peptidase M50
F1847_RS03050	COG0793	Belongs to the peptidase S41A family
F1847_RS03055	COG1333	cytochrome c biogenesis protein
F1847_RS03080	COG3301	Polysulphide reductase, NrfD
F1847_RS03085	COG1185	polyribonucleotide nucleotidyltransferase activity
F1847_RS03090	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
F1847_RS03095	COG1530	ribonuclease E activity
F1847_RS03100	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
F1847_RS03110	COG1132	(ABC) transporter
F1847_RS03115	COG0501	Belongs to the peptidase M48B family
F1847_RS03125	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
F1847_RS03135	COG1490	D-aminoacyl-tRNA deacylase activity
F1847_RS03160	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
F1847_RS03165	COG0509	glycine decarboxylation via glycine cleavage system
F1847_RS03170	COG2257	FlhB HrpN YscU SpaS Family
F1847_RS03175	COG1980	fructose-bisphosphate aldolase activity
F1847_RS03195	COG0436	Aminotransferase
F1847_RS03205	COG1067	ATP-dependent peptidase activity
F1847_RS03210	COG0538	isocitrate dehydrogenase activity
F1847_RS03220	COG0495	leucyl-tRNA aminoacylation
F1847_RS03230	COG1458	PINc domain ribonuclease
F1847_RS03235	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
F1847_RS03240	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
F1847_RS03245	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
F1847_RS03255	COG1193	negative regulation of DNA recombination
F1847_RS03260	COG0358	DNA primase activity
F1847_RS03260	COG0305	Participates in initiation and elongation during chromosome replication
F1847_RS03270	COG1522	sequence-specific DNA binding
F1847_RS03280	COG4783	chaperone-mediated protein folding
F1847_RS03290	COG0010	Belongs to the arginase family
F1847_RS03310	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
F1847_RS03320	COG4974	Belongs to the 'phage' integrase family
F1847_RS03325	COG0617	tRNA 3'-terminal CCA addition
F1847_RS03330	COG3706	GGDEF domain
F1847_RS03335	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
F1847_RS03350	COG1058	Belongs to the CinA family
F1847_RS03350	COG1546	Belongs to the CinA family
F1847_RS03370	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
F1847_RS03385	COG0154	amidase activity
F1847_RS03390	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
F1847_RS03395	COG0351	phosphomethylpyrimidine kinase
F1847_RS03400	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
F1847_RS03410	COG0706	membrane insertase activity
F1847_RS03415	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
F1847_RS03420	COG0594	ribonuclease P activity
F1847_RS03425	COG0230	Belongs to the bacterial ribosomal protein bL34 family
F1847_RS03430	COG0134	indole-3-glycerol-phosphate synthase activity
F1847_RS03435	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
F1847_RS03440	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
F1847_RS03455	COG3706	GGDEF domain
F1847_RS03470	COG1516	flagellar protein fliS
F1847_RS03475	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
F1847_RS03490	COG0489	protein tyrosine kinase activity
F1847_RS03510	COG0174	glutamine synthetase
F1847_RS03515	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
F1847_RS03515	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
F1847_RS03520	COG2067	long-chain fatty acid transport protein
F1847_RS03525	COG0204	Acyl-transferase
F1847_RS03525	COG0318	PFAM AMP-dependent synthetase and ligase
F1847_RS03530	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
F1847_RS03535	COG0477	Major facilitator Superfamily
F1847_RS03540	COG2045	Belongs to the ComB family
F1847_RS03550	COG3454	Phosphonate metabolism
F1847_RS03555	COG4778	phosphonate C-P lyase system protein PhnL
F1847_RS03560	COG4107	phosphonate C-P lyase system protein PhnK
F1847_RS03565	COG3627	carbon phosphorus lyase activity
F1847_RS03585	COG3639	organic phosphonate transmembrane transporter activity
F1847_RS03590	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
F1847_RS03640	COG3328	transposase activity
F1847_RS03675	COG0497	DNA recombination
F1847_RS03690	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
F1847_RS03700	COG2204	response regulator
F1847_RS03705	COG1635	Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur
F1847_RS03710	COG0322	excinuclease ABC activity
F1847_RS03715	COG0473	3-isopropylmalate dehydrogenase activity
F1847_RS03720	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
F1847_RS03730	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
F1847_RS03735	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
F1847_RS03745	COG2204	response regulator
F1847_RS03750	COG2855	membrane
F1847_RS03765	COG0067	glutamate synthase
F1847_RS03775	COG3284	Transcriptional regulator
F1847_RS03780	COG0174	glutamine synthetase
F1847_RS03790	COG0347	Belongs to the P(II) protein family
F1847_RS03795	COG0004	ammonium transporteR
F1847_RS03815	COG0113	porphobilinogen synthase activity
F1847_RS03820	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
F1847_RS03825	COG0571	ribonuclease III activity
F1847_RS03835	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
F1847_RS03845	COG0735	belongs to the Fur family
F1847_RS03850	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
F1847_RS03865	COG2414	aldehyde ferredoxin oxidoreductase
F1847_RS03885	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
F1847_RS03900	COG0803	Belongs to the bacterial solute-binding protein 9 family
F1847_RS03905	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
F1847_RS03910	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
F1847_RS03915	COG1968	undecaprenyl-diphosphatase activity
F1847_RS03920	COG1090	epimerase
F1847_RS03930	COG0840	transmembrane signaling receptor activity
F1847_RS03930	COG5278	phosphoserine phosphatase activity
F1847_RS03940	COG0840	transmembrane signaling receptor activity
F1847_RS03945	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
F1847_RS03955	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
F1847_RS03965	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
F1847_RS03970	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
F1847_RS03980	COG0181	hydroxymethylbilane synthase activity
F1847_RS03990	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
F1847_RS04005	COG0438	transferase activity, transferring glycosyl groups
F1847_RS04010	COG0367	asparagine synthase
F1847_RS04025	COG0438	transferase activity, transferring glycosyl groups
F1847_RS04045	COG0438	transferase activity, transferring glycosyl groups
F1847_RS04045	COG0297	glycogen (starch) synthase activity
F1847_RS04050	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
F1847_RS04070	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
F1847_RS04080	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
F1847_RS04085	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
F1847_RS04090	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
F1847_RS04095	COG0574	Belongs to the PEP-utilizing enzyme family
F1847_RS04095	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
F1847_RS04100	COG0456	acetyltransferase
F1847_RS04105	COG1660	Displays ATPase and GTPase activities
F1847_RS04115	COG0542	response to heat
F1847_RS04125	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
F1847_RS04130	COG0105	UTP biosynthetic process
F1847_RS04145	COG0107	imidazoleglycerol-phosphate synthase activity
F1847_RS04155	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
F1847_RS04160	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
F1847_RS04165	COG0671	phosphoesterase, PA-phosphatase related
F1847_RS04170	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
F1847_RS04175	COG0137	argininosuccinate synthase activity
F1847_RS04185	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
F1847_RS04190	COG2877	3-deoxy-8-phosphooctulonate synthase activity
F1847_RS04195	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
F1847_RS04205	COG2003	Belongs to the UPF0758 family
F1847_RS04210	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
F1847_RS04215	COG0590	tRNA wobble adenosine to inosine editing
F1847_RS04220	COG3706	GGDEF domain
F1847_RS04235	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
F1847_RS04245	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
F1847_RS04250	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
F1847_RS04265	COG0756	dUTP diphosphatase activity
F1847_RS04270	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
F1847_RS04275	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
F1847_RS04280	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
F1847_RS04305	COG0438	transferase activity, transferring glycosyl groups
F1847_RS04325	COG0557	exoribonuclease II activity
F1847_RS04330	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
F1847_RS04335	COG0864	Transcriptional regulator
F1847_RS04365	COG1253	flavin adenine dinucleotide binding
F1847_RS04370	COG1253	flavin adenine dinucleotide binding
F1847_RS04390	COG0602	queuosine metabolic process
F1847_RS04450	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
F1847_RS04455	COG0525	valine-tRNA ligase activity
F1847_RS04465	COG1196	nuclear chromosome segregation
F1847_RS04480	COG0210	DNA helicase
F1847_RS04485	COG0577	efflux transmembrane transporter activity
F1847_RS04485	COG1136	(ABC) transporter
F1847_RS04490	COG0577	efflux transmembrane transporter activity
F1847_RS04490	COG1136	(ABC) transporter
F1847_RS04495	COG0577	efflux transmembrane transporter activity
F1847_RS04495	COG1136	(ABC) transporter
F1847_RS04500	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
F1847_RS04510	COG0531	amino acid
F1847_RS04515	COG2095	MarC family integral membrane protein
F1847_RS04525	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
F1847_RS04535	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
F1847_RS04545	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
F1847_RS04550	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
F1847_RS04555	COG1355	regulation of microtubule-based process
F1847_RS04560	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
F1847_RS04570	COG0268	Binds directly to 16S ribosomal RNA
F1847_RS04585	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
F1847_RS04600	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
F1847_RS04605	COG0439	Biotin carboxylase
F1847_RS04610	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
F1847_RS04620	COG0779	Required for maturation of 30S ribosomal subunits
F1847_RS04625	COG0195	Participates in both transcription termination and antitermination
F1847_RS04635	COG1605	Chorismate mutase
F1847_RS04635	COG0077	Prephenate dehydratase
F1847_RS04640	COG0501	Belongs to the peptidase M48B family
F1847_RS04650	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
F1847_RS04655	COG1619	proteins homologs of microcin C7 resistance protein MccF
F1847_RS04660	COG0643	Histidine kinase
F1847_RS04660	COG2198	Histidine kinase
F1847_RS04675	COG0840	transmembrane signaling receptor activity
F1847_RS04680	COG0328	RNA-DNA hybrid ribonuclease activity
F1847_RS04685	COG0163	prenyltransferase activity
F1847_RS04690	COG0815	Transfers the fatty acyl group on membrane lipoproteins
F1847_RS04695	COG1253	flavin adenine dinucleotide binding
F1847_RS04750	COG5001	Diguanylate cyclase
F1847_RS04755	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
F1847_RS04760	COG0719	Fe-S assembly protein
F1847_RS04770	COG1294	oxidase, subunit
F1847_RS04775	COG1271	oxidase subunit
F1847_RS04785	COG5001	Diguanylate cyclase
F1847_RS04785	COG3300	MHYT domain
F1847_RS04790	COG0469	pyruvate kinase activity
F1847_RS04805	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
F1847_RS04840	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
F1847_RS04845	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
F1847_RS04855	COG0310	cobalt ion transport
F1847_RS04860	COG0310	cobalt ion transport
F1847_RS04890	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
F1847_RS04920	COG2201	protein-glutamate methylesterase activity
F1847_RS04925	COG0745	RESPONSE REGULATOR receiver
F1847_RS04950	COG1191	sigma factor activity
F1847_RS04960	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
F1847_RS04965	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
F1847_RS04970	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
F1847_RS04975	COG1684	flagellar biosynthetic protein fliR
F1847_RS04980	COG1987	bacterial-type flagellum assembly
F1847_RS04985	COG1338	Plays a role in the flagellum-specific transport system
F1847_RS05025	COG1519	Transferase
F1847_RS05025	COG0220	tRNA (guanine-N7-)-methyltransferase activity
F1847_RS05030	COG1496	oxidoreductase activity
F1847_RS05035	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
F1847_RS05040	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
F1847_RS05055	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
F1847_RS05060	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
F1847_RS05065	COG1489	DNA binding
F1847_RS05080	COG0730	response to heat
F1847_RS05090	COG3901	Regulator of nitric oxide reductase transcription
F1847_RS05090	COG0348	domain, Protein
F1847_RS05095	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
F1847_RS05105	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
F1847_RS05110	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
F1847_RS05115	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
F1847_RS05150	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
F1847_RS05165	COG0445	tRNA wobble uridine modification
F1847_RS05170	COG0592	DNA-directed DNA polymerase activity
F1847_RS05175	COG0187	DNA topoisomerase II activity
F1847_RS05180	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
F1847_RS05185	COG2391	methyltransferase activity
F1847_RS05190	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
F1847_RS05195	COG1796	DNA polymerase
F1847_RS05195	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
F1847_RS05200	COG1686	Belongs to the peptidase S11 family
F1847_RS05205	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
F1847_RS05210	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
F1847_RS05215	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
F1847_RS05220	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
F1847_RS05225	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
F1847_RS05235	COG0138	bifunctional purine biosynthesis protein purh
F1847_RS05240	COG0535	radical SAM domain protein
F1847_RS05250	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
F1847_RS05255	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
F1847_RS05260	COG1210	Utp--glucose-1-phosphate uridylyltransferase
F1847_RS05290	COG0482	sulfurtransferase activity
F1847_RS05300	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
F1847_RS05310	COG0617	tRNA 3'-terminal CCA addition
F1847_RS05315	COG0445	tRNA wobble uridine modification
F1847_RS05325	COG3328	transposase activity
F1847_RS05335	COG0697	spore germination
F1847_RS05340	COG1187	pseudouridine synthase activity
F1847_RS05350	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
F1847_RS05360	COG0037	tRNA processing
F1847_RS05365	COG1773	rubredoxin
F1847_RS05370	COG1434	Gram-negative-bacterium-type cell wall biogenesis
F1847_RS05375	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
F1847_RS05385	COG2204	response regulator
F1847_RS05395	COG0037	tRNA processing
F1847_RS05400	COG0277	FAD linked oxidase domain protein
F1847_RS05405	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
F1847_RS05410	COG4608	Belongs to the ABC transporter superfamily
F1847_RS05415	COG0444	Belongs to the ABC transporter superfamily
F1847_RS05425	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
F1847_RS05430	COG1032	radical SAM domain protein
F1847_RS05445	COG0674	pyruvate-flavodoxin oxidoreductase activity
F1847_RS05450	COG1013	pyruvate-flavodoxin oxidoreductase activity
F1847_RS05460	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
F1847_RS05490	COG0531	amino acid
F1847_RS05505	COG0704	Plays a role in the regulation of phosphate uptake
F1847_RS05510	COG0681	Belongs to the peptidase S26 family
F1847_RS05515	COG0481	GTPase activity
F1847_RS05525	COG1131	(ABC) transporter
F1847_RS05535	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
F1847_RS05540	COG0180	Tryptophanyl-tRNA synthetase
F1847_RS05555	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
F1847_RS05570	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
F1847_RS05580	COG0513	Belongs to the DEAD box helicase family
F1847_RS05585	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
F1847_RS05590	COG0521	Mo-molybdopterin cofactor biosynthetic process
F1847_RS05600	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
F1847_RS05630	COG0425	Belongs to the sulfur carrier protein TusA family
F1847_RS05655	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
F1847_RS05670	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
F1847_RS05680	COG0220	tRNA (guanine-N7-)-methyltransferase activity
F1847_RS05685	COG1538	Outer membrane efflux protein
F1847_RS05695	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
F1847_RS05700	COG1309	transcriptional regulator
F1847_RS05715	COG0436	Aminotransferase
F1847_RS05730	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
F1847_RS05765	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
F1847_RS05785	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
F1847_RS05795	COG1797	cobyrinic acid a,c-diamide synthase activity
F1847_RS05835	COG0037	tRNA processing
F1847_RS05850	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
F1847_RS05855	COG0211	Belongs to the bacterial ribosomal protein bL27 family
F1847_RS05860	COG0261	This protein binds to 23S rRNA in the presence of protein L20
F1847_RS05870	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
F1847_RS05875	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
F1847_RS05880	COG1979	alcohol dehydrogenase
F1847_RS05895	COG0402	S-adenosylhomocysteine deaminase activity
F1847_RS05900	COG0857	belongs to the CobB CobQ family
F1847_RS05905	COG0242	peptide deformylase activity
F1847_RS05910	COG1692	metallophosphoesterase
F1847_RS05915	COG1418	mRNA catabolic process
F1847_RS05960	COG1418	mRNA catabolic process
F1847_RS05960	COG3599	regulation of cell shape
F1847_RS05970	COG0460	homoserine dehydrogenase
F1847_RS05975	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
F1847_RS05985	COG0792	nuclease activity
F1847_RS05990	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
F1847_RS05995	COG0335	large ribosomal subunit rRNA binding
F1847_RS06005	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
F1847_RS06020	COG0758	DNA mediated transformation
F1847_RS06020	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
F1847_RS06030	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
F1847_RS06035	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
F1847_RS06040	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
F1847_RS06045	COG0579	oxidoreductase
F1847_RS06050	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
F1847_RS06055	COG0066	3-isopropylmalate dehydratase activity
F1847_RS06060	COG3956	TIGRFAM MazG family protein
F1847_RS06065	COG1121	(ABC) transporter
F1847_RS06070	COG1108	ABC-type Mn2 Zn2 transport systems permease components
F1847_RS06075	COG0084	hydrolase, TatD family'
F1847_RS06080	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
F1847_RS06090	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
F1847_RS06095	COG2086	electron transfer activity
F1847_RS06100	COG1960	acyl-CoA dehydrogenase activity
F1847_RS06105	COG1555	photosystem II stabilization
F1847_RS06105	COG1596	polysaccharide export
F1847_RS06110	COG2920	part of a sulfur-relay system
F1847_RS06125	COG0018	arginyl-trna synthetase
F1847_RS06135	COG0564	pseudouridine synthase activity
F1847_RS06145	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
F1847_RS06150	COG0443	Heat shock 70 kDa protein
F1847_RS06155	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
F1847_RS06160	COG0157	Belongs to the NadC ModD family
F1847_RS06165	COG1227	inorganic diphosphatase activity
F1847_RS06190	COG1160	GTP binding
F1847_RS06205	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
F1847_RS06210	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
F1847_RS06215	COG0355	proton-transporting ATP synthase activity, rotational mechanism
F1847_RS06220	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
F1847_RS06225	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
F1847_RS06230	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
F1847_RS06235	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
F1847_RS06245	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
F1847_RS06250	COG0772	Belongs to the SEDS family
F1847_RS06255	COG0768	penicillin binding
F1847_RS06265	COG1792	Involved in formation and maintenance of cell shape
F1847_RS06285	COG1234	tRNA 3'-trailer cleavage
F1847_RS06300	COG0436	Aminotransferase
F1847_RS06305	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
F1847_RS06320	COG4786	Flagellar basal body rod
F1847_RS06320	COG1256	bacterial-type flagellum assembly
F1847_RS06335	COG1706	bacterial-type flagellum-dependent cell motility
F1847_RS06340	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
F1847_RS06355	COG4786	Flagellar basal body rod
F1847_RS06360	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
F1847_RS06375	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
F1847_RS06380	COG0019	diaminopimelate decarboxylase activity
F1847_RS06385	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
F1847_RS06390	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
F1847_RS06400	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
F1847_RS06405	COG2989	Protein conserved in bacteria
F1847_RS06415	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
F1847_RS06425	COG1837	Belongs to the UPF0109 family
F1847_RS06430	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
F1847_RS06435	COG4752	Belongs to the RNA methyltransferase TrmD family
F1847_RS06435	COG0336	Belongs to the RNA methyltransferase TrmD family
F1847_RS06440	COG0439	Biotin carboxylase
F1847_RS06445	COG0511	ligase activity, forming carbon-carbon bonds
F1847_RS06450	COG0537	adenosine 5'-monophosphoramidase activity
F1847_RS06455	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
F1847_RS06455	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
F1847_RS06460	COG1774	PSP1 C-terminal conserved region
F1847_RS06465	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
F1847_RS06475	COG2835	tetraacyldisaccharide 4'-kinase activity
F1847_RS06480	COG3706	GGDEF domain
F1847_RS06495	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
F1847_RS06510	COG1522	sequence-specific DNA binding
F1847_RS06520	COG5000	phosphorelay sensor kinase activity
F1847_RS06535	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
F1847_RS06535	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
F1847_RS06540	COG0736	holo-[acyl-carrier-protein] synthase activity
F1847_RS06545	COG0698	ribose 5-phosphate isomerase
F1847_RS06550	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
F1847_RS06555	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
F1847_RS06570	COG0693	protein deglycase activity
F1847_RS06585	COG4974	Belongs to the 'phage' integrase family
F1847_RS06600	COG1278	Cold shock
F1847_RS06610	COG1892	Catalyzes the irreversible beta-carboxylation of phosphoenolpyruvate (PEP) to form oxaloacetate (OAA), a four- carbon dicarboxylic acid source for the tricarboxylic acid cycle
F1847_RS06615	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
F1847_RS06645	COG0504	CTP synthase activity
F1847_RS06650	COG0613	PHP domain protein
F1847_RS06655	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
F1847_RS06680	COG0728	peptidoglycan biosynthetic process
F1847_RS06685	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
F1847_RS06685	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
F1847_RS06690	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
F1847_RS06705	COG0848	biopolymer transport protein
F1847_RS06710	COG0811	peptide transport
F1847_RS06715	COG0635	Involved in the biosynthesis of porphyrin-containing compound
F1847_RS06720	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
F1847_RS06740	COG1959	2 iron, 2 sulfur cluster binding
F1847_RS06755	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
F1847_RS06775	COG0356	it plays a direct role in the translocation of protons across the membrane
F1847_RS06780	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
F1847_RS06785	COG0606	chelatase, subunit chli
F1847_RS06795	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
F1847_RS06795	COG0425	Belongs to the sulfur carrier protein TusA family
F1847_RS06815	COG0306	phosphate transporter
F1847_RS06855	COG3259	Nickel-dependent hydrogenase
F1847_RS06880	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
F1847_RS06885	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
F1847_RS06890	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
F1847_RS06900	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
F1847_RS06905	COG0167	dihydroorotate dehydrogenase activity
F1847_RS06920	COG1388	LysM domain
F1847_RS06920	COG0791	NLP P60 protein
F1847_RS06930	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
F1847_RS06930	COG0517	IMP dehydrogenase activity
F1847_RS06935	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
F1847_RS06940	COG1193	negative regulation of DNA recombination
F1847_RS06955	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
F1847_RS06960	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
F1847_RS06965	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
F1847_RS06970	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
F1847_RS06980	COG3034	peptidoglycan biosynthetic process
F1847_RS06995	COG1040	competence protein
F1847_RS07000	COG2195	Cleaves the N-terminal amino acid of tripeptides
F1847_RS07005	COG1254	Belongs to the acylphosphatase family
F1847_RS07085	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
F1847_RS07090	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
F1847_RS07095	COG0085	RNA polymerase activity
F1847_RS07100	COG0222	ribosome binding
F1847_RS07105	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
F1847_RS07115	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
F1847_RS07135	COG0267	Belongs to the bacterial ribosomal protein bL33 family
F1847_RS07140	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
F1847_RS07170	COG1233	COG1233 Phytoene dehydrogenase and related
F1847_RS07190	COG2046	Belongs to the sulfate adenylyltransferase family
F1847_RS07195	COG0142	geranyltranstransferase activity
F1847_RS07205	COG1074	ATP-dependent DNA helicase activity
F1847_RS07210	COG1385	rRNA (uridine-N3-)-methyltransferase activity
F1847_RS07225	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
F1847_RS07235	COG0552	protein localization to endoplasmic reticulum
F1847_RS07245	COG0437	4 iron, 4 sulfur cluster binding
F1847_RS07255	COG3328	transposase activity
F1847_RS07270	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
F1847_RS07275	COG1518	maintenance of DNA repeat elements
F1847_RS07325	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
F1847_RS07330	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
F1847_RS07335	COG4206	TonB-dependent receptor
F1847_RS07345	COG5002	protein histidine kinase activity
F1847_RS07350	COG0745	RESPONSE REGULATOR receiver
F1847_RS07355	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
F1847_RS07370	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
F1847_RS07375	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
F1847_RS07380	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
F1847_RS07425	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
F1847_RS07440	COG0360	Binds together with S18 to 16S ribosomal RNA
F1847_RS07445	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
F1847_RS07450	COG0359	binds to the 23S rRNA
F1847_RS07455	COG0305	Participates in initiation and elongation during chromosome replication
F1847_RS07480	COG0442	prolyl-tRNA aminoacylation
F1847_RS07490	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
F1847_RS07495	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
F1847_RS07500	COG0312	modulator of DNA gyrase
F1847_RS07515	COG0218	Necessary for normal cell division and for the maintenance of normal septation
F1847_RS07520	COG3162	membrane
F1847_RS07525	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
F1847_RS07535	COG2176	DNA-directed DNA polymerase activity
F1847_RS07555	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
F1847_RS07560	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
F1847_RS07575	COG1027	Aspartate ammonia-lyase
F1847_RS07585	COG4624	Iron only hydrogenase large subunit, C-terminal domain
F1847_RS07585	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
F1847_RS07600	COG1295	ribonuclease BN
F1847_RS07615	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
F1847_RS07625	COG3409	Peptidoglycan-binding domain 1 protein
F1847_RS07625	COG3267	Type II secretory pathway component ExeA
F1847_RS07660	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
F1847_RS07660	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
F1847_RS07665	COG0589	response to stress
F1847_RS07690	COG2188	Transcriptional regulator
F1847_RS07705	COG3328	transposase activity
F1847_RS07710	COG0469	pyruvate kinase activity
F1847_RS07715	COG2204	response regulator
F1847_RS07730	COG4191	Histidine kinase
F1847_RS07735	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
F1847_RS07740	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
F1847_RS07745	COG0375	protein maturation
F1847_RS07760	COG0492	ferredoxin-NADP+ reductase activity
F1847_RS07770	COG3852	Histidine kinase
F1847_RS07780	COG0840	transmembrane signaling receptor activity
F1847_RS07785	COG1007	ATP synthesis coupled electron transport
F1847_RS07795	COG0651	ATP synthesis coupled electron transport
F1847_RS07805	COG0651	ATP synthesis coupled electron transport
F1847_RS07810	COG0713	ATP synthesis coupled electron transport
F1847_RS07815	COG0839	Belongs to the complex I subunit 6 family
F1847_RS07830	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
F1847_RS07835	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
F1847_RS07840	COG0649	NAD binding
F1847_RS07845	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
F1847_RS07850	COG0437	4 iron, 4 sulfur cluster binding
F1847_RS07860	COG5557	Pfam Polysulphide reductase, NrfD
F1847_RS07865	COG0437	4 iron, 4 sulfur cluster binding
F1847_RS07865	COG3064	Membrane
F1847_RS07870	COG0484	heat shock protein binding
F1847_RS07875	COG0247	lactate metabolic process
F1847_RS07890	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
F1847_RS07895	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
F1847_RS07910	COG0437	4 iron, 4 sulfur cluster binding
F1847_RS07930	COG1910	domain protein
F1847_RS07935	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
F1847_RS07945	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
F1847_RS07975	COG0574	Belongs to the PEP-utilizing enzyme family
F1847_RS07975	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
F1847_RS08000	COG2204	response regulator
F1847_RS08010	COG3852	Histidine kinase
F1847_RS08015	COG2204	response regulator
F1847_RS08020	COG0745	RESPONSE REGULATOR receiver
F1847_RS08025	COG0469	pyruvate kinase activity
F1847_RS08035	COG0438	transferase activity, transferring glycosyl groups
F1847_RS08055	COG0438	transferase activity, transferring glycosyl groups
F1847_RS08060	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
F1847_RS08080	COG1077	Cell shape determining protein MreB Mrl
F1847_RS08095	COG0436	Aminotransferase
F1847_RS08100	COG1260	myo-inositol-1-phosphate synthase
F1847_RS08105	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
F1847_RS08115	COG0512	Glutamine amidotransferase of anthranilate synthase
F1847_RS08125	COG0124	histidyl-tRNA synthetase
F1847_RS08130	COG0446	pyridine nucleotide-disulphide oxidoreductase
F1847_RS08135	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
F1847_RS08135	COG1918	ferrous iron import across plasma membrane
F1847_RS08140	COG0006	proline dipeptidase activity
F1847_RS08165	COG1353	crispr-associated protein
F1847_RS08175	COG1337	RAMP superfamily
F1847_RS08220	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
F1847_RS08225	COG1518	maintenance of DNA repeat elements
F1847_RS08255	COG0352	thiamine-phosphate diphosphorylase activity
F1847_RS08260	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
F1847_RS08275	COG1230	cation diffusion facilitator family transporter
F1847_RS08280	COG5000	phosphorelay sensor kinase activity
F1847_RS08285	COG2204	response regulator
F1847_RS08300	COG0589	response to stress
F1847_RS08315	COG1139	Iron-sulfur cluster binding protein
F1847_RS08320	COG1556	Lactate utilization protein
F1847_RS08325	COG0247	lactate metabolic process
F1847_RS08330	COG0277	FAD linked oxidase domain protein
F1847_RS08335	COG1620	l-lactate permease
F1847_RS08345	COG0857	belongs to the CobB CobQ family
F1847_RS08360	COG0674	pyruvate-flavodoxin oxidoreductase activity
F1847_RS08365	COG1013	pyruvate-flavodoxin oxidoreductase activity
F1847_RS08385	COG2111	Na H antiporter
F1847_RS08385	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
F1847_RS08390	COG1007	ATP synthesis coupled electron transport
F1847_RS08395	COG3260	NADH ubiquinone oxidoreductase 20
F1847_RS08405	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
F1847_RS08440	COG2226	methyltransferase
F1847_RS08450	COG0402	S-adenosylhomocysteine deaminase activity
F1847_RS08455	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
F1847_RS08460	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
F1847_RS08475	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
F1847_RS08485	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
F1847_RS08490	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
F1847_RS08500	COG1611	Belongs to the LOG family
F1847_RS08515	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
F1847_RS08525	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
F1847_RS08530	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
F1847_RS08540	COG0741	lytic transglycosylase activity
F1847_RS08555	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
F1847_RS08560	COG1469	GTP cyclohydrolase I activity
F1847_RS08600	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
F1847_RS08605	COG2759	Belongs to the formate--tetrahydrofolate ligase family
F1847_RS08610	COG0612	Peptidase, M16
F1847_RS08615	COG0802	atpase or kinase
F1847_RS08630	COG2885	chlorophyll binding
F1847_RS08675	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
F1847_RS08745	COG0133	tryptophan synthase activity
F1847_RS08750	COG0159	tryptophan synthase activity
F1847_RS08755	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
F1847_RS08760	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
F1847_RS08765	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
F1847_RS08785	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
F1847_RS08810	COG3328	transposase activity
F1847_RS08835	COG0655	NAD(P)H dehydrogenase (quinone) activity
F1847_RS08845	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
F1847_RS08860	COG4943	cyclic-guanylate-specific phosphodiesterase activity
F1847_RS08865	COG0517	IMP dehydrogenase activity
F1847_RS08865	COG0516	GMP reductase activity
F1847_RS08870	COG0587	DNA-directed DNA polymerase activity
F1847_RS08875	COG1528	Iron-storage protein
F1847_RS08880	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
F1847_RS08880	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
F1847_RS08885	COG0556	nucleotide-excision repair
F1847_RS08900	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
F1847_RS08910	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
F1847_RS08935	COG0028	Belongs to the TPP enzyme family
F1847_RS08945	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
F1847_RS08950	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
F1847_RS08960	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
F1847_RS08995	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
F1847_RS09000	COG0254	rRNA binding
F1847_RS09010	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
F1847_RS09015	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
F1847_RS09020	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
F1847_RS09025	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
F1847_RS09060	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
F1847_RS09065	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
F1847_RS09070	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
F1847_RS09075	COG1110	DNA topoisomerase II activity
F1847_RS09080	COG1104	cysteine desulfurase activity
F1847_RS09090	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
F1847_RS09100	COG0742	ribosomal rna small subunit methyltransferase
F1847_RS09105	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
F1847_RS09110	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
F1847_RS09120	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
F1847_RS09155	COG0012	GTP binding
F1847_RS09160	COG0824	Thioesterase
F1847_RS09165	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant