locus-tag	class	description
TDSAC_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
TDSAC_RS00010	COG0592	DNA-directed DNA polymerase activity
TDSAC_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
TDSAC_RS00025	COG0187	DNA topoisomerase II activity
TDSAC_RS00030	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
TDSAC_RS00035	COG0142	geranyltranstransferase activity
TDSAC_RS00045	COG1191	sigma factor activity
TDSAC_RS00060	COG1360	Flagellar Motor Protein
TDSAC_RS00070	COG2201	protein-glutamate methylesterase activity
TDSAC_RS00080	COG1338	Plays a role in the flagellum-specific transport system
TDSAC_RS00085	COG2201	protein-glutamate methylesterase activity
TDSAC_RS00090	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
TDSAC_RS00095	COG1776	CheC inhibitor of MCP methylation
TDSAC_RS00100	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
TDSAC_RS00105	COG1987	bacterial-type flagellum assembly
TDSAC_RS00110	COG1684	flagellar biosynthetic protein fliR
TDSAC_RS00115	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
TDSAC_RS00140	COG0643	Histidine kinase
TDSAC_RS00140	COG2198	Histidine kinase
TDSAC_RS00150	COG1815	bacterial-type flagellum-dependent cell motility
TDSAC_RS00155	COG0741	lytic transglycosylase activity
TDSAC_RS00160	COG3300	MHYT domain
TDSAC_RS00160	COG5001	Diguanylate cyclase
TDSAC_RS00180	COG1151	hydroxylamine reductase activity
TDSAC_RS00220	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
TDSAC_RS00225	COG0459	protein refolding
TDSAC_RS00230	COG3290	protein histidine kinase activity
TDSAC_RS00230	COG0840	transmembrane signaling receptor activity
TDSAC_RS00250	COG0405	Gamma-glutamyltransferase
TDSAC_RS00255	COG0277	FAD linked oxidase domain protein
TDSAC_RS00260	COG0450	alkyl hydroperoxide reductase
TDSAC_RS00280	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
TDSAC_RS00290	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
TDSAC_RS00305	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
TDSAC_RS00310	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
TDSAC_RS00315	COG2877	3-deoxy-8-phosphooctulonate synthase activity
TDSAC_RS00320	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
TDSAC_RS00320	COG0517	IMP dehydrogenase activity
TDSAC_RS00325	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
TDSAC_RS00335	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
TDSAC_RS00345	COG1285	pathogenesis
TDSAC_RS00360	COG1067	ATP-dependent peptidase activity
TDSAC_RS00375	COG0826	peptidase U32
TDSAC_RS00380	COG0419	ATPase involved in DNA repair
TDSAC_RS00385	COG0420	3'-5' exonuclease activity
TDSAC_RS00405	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
TDSAC_RS00410	COG1140	nitrate reductase beta subunit
TDSAC_RS00420	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
TDSAC_RS00425	COG2181	nitrate reductase activity
TDSAC_RS00430	COG0426	domain, Protein
TDSAC_RS00450	COG2226	methyltransferase
TDSAC_RS00460	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
TDSAC_RS00465	COG0644	oxidoreductase
TDSAC_RS00475	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TDSAC_RS00510	COG0067	glutamate synthase
TDSAC_RS00510	COG0069	glutamate synthase activity
TDSAC_RS00510	COG0070	glutamate synthase
TDSAC_RS00515	COG0493	'glutamate synthase
TDSAC_RS00520	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
TDSAC_RS00525	COG0511	ligase activity, forming carbon-carbon bonds
TDSAC_RS00530	COG0439	Biotin carboxylase
TDSAC_RS00535	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
TDSAC_RS00540	COG0107	imidazoleglycerol-phosphate synthase activity
TDSAC_RS00545	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
TDSAC_RS00550	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
TDSAC_RS00555	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
TDSAC_RS00560	COG1160	GTP binding
TDSAC_RS00565	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
TDSAC_RS00590	COG0859	PFAM glycosyl transferase family 9
TDSAC_RS00595	COG0497	DNA recombination
TDSAC_RS00625	COG2033	superoxide reductase activity
TDSAC_RS00635	COG5298	Protein conserved in bacteria
TDSAC_RS00650	COG0497	DNA recombination
TDSAC_RS00665	COG0347	Belongs to the P(II) protein family
TDSAC_RS00670	COG0019	diaminopimelate decarboxylase activity
TDSAC_RS00675	COG0726	polysaccharide deacetylase
TDSAC_RS00680	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
TDSAC_RS00690	COG1418	mRNA catabolic process
TDSAC_RS00695	COG1692	metallophosphoesterase
TDSAC_RS00700	COG0343	queuine tRNA-ribosyltransferase activity
TDSAC_RS00705	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
TDSAC_RS00710	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
TDSAC_RS00725	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
TDSAC_RS00735	COG1674	ftsk spoiiie
TDSAC_RS00750	COG0529	Catalyzes the synthesis of activated sulfate
TDSAC_RS00755	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
TDSAC_RS00760	COG0463	Glycosyl transferase, family 2
TDSAC_RS00760	COG1216	Glycosyl transferase, family 2
TDSAC_RS00800	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
TDSAC_RS00810	COG1157	protein secretion by the type III secretion system
TDSAC_RS00815	COG1419	protein localization to endoplasmic reticulum
TDSAC_RS00830	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
TDSAC_RS00845	COG1215	transferase activity, transferring glycosyl groups
TDSAC_RS00860	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
TDSAC_RS00865	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
TDSAC_RS00875	COG0281	malic enzyme
TDSAC_RS00895	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
TDSAC_RS00900	COG0493	'glutamate synthase
TDSAC_RS00915	COG0481	GTPase activity
TDSAC_RS00920	COG0635	Involved in the biosynthesis of porphyrin-containing compound
TDSAC_RS00935	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
TDSAC_RS00935	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
TDSAC_RS00940	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
TDSAC_RS00945	COG0322	excinuclease ABC activity
TDSAC_RS00950	COG0739	heme binding
TDSAC_RS00955	COG0739	heme binding
TDSAC_RS00960	COG0612	Peptidase, M16
TDSAC_RS00965	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TDSAC_RS00970	COG2359	stage V sporulation protein S
TDSAC_RS00975	COG1187	pseudouridine synthase activity
TDSAC_RS00980	COG0425	Belongs to the sulfur carrier protein TusA family
TDSAC_RS00985	COG1104	cysteine desulfurase activity
TDSAC_RS00995	COG0728	peptidoglycan biosynthetic process
TDSAC_RS01005	COG2359	stage V sporulation protein S
TDSAC_RS01015	COG0739	heme binding
TDSAC_RS01025	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
TDSAC_RS01030	COG0393	Putative heavy-metal-binding
TDSAC_RS01035	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TDSAC_RS01035	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TDSAC_RS01040	COG0084	hydrolase, TatD family'
TDSAC_RS01045	COG1355	regulation of microtubule-based process
TDSAC_RS01050	COG1324	tolerance protein
TDSAC_RS01055	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
TDSAC_RS01070	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
TDSAC_RS01100	COG1105	Belongs to the carbohydrate kinase PfkB family
TDSAC_RS01110	COG0805	protein transport
TDSAC_RS01115	COG0746	molybdenum cofactor guanylyltransferase activity
TDSAC_RS01120	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
TDSAC_RS01125	COG2252	PERMEase
TDSAC_RS01130	COG1217	gtp-binding protein TYPA
TDSAC_RS01135	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
TDSAC_RS01145	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
TDSAC_RS01145	COG2199	diguanylate cyclase activity
TDSAC_RS01150	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
TDSAC_RS01155	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
TDSAC_RS01160	COG0583	DNA-binding transcription factor activity
TDSAC_RS01165	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
TDSAC_RS01170	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
TDSAC_RS01175	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
TDSAC_RS01185	COG0438	transferase activity, transferring glycosyl groups
TDSAC_RS01195	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
TDSAC_RS01205	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
TDSAC_RS01215	COG1309	transcriptional regulator
TDSAC_RS01225	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
TDSAC_RS01230	COG0438	transferase activity, transferring glycosyl groups
TDSAC_RS01235	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
TDSAC_RS01240	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
TDSAC_RS01245	COG1793	dna ligase
TDSAC_RS01255	COG2199	diguanylate cyclase activity
TDSAC_RS01255	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
TDSAC_RS01265	COG0012	GTP binding
TDSAC_RS01280	COG0360	Binds together with S18 to 16S ribosomal RNA
TDSAC_RS01285	COG0629	single-stranded DNA binding
TDSAC_RS01290	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
TDSAC_RS01305	COG0358	DNA primase activity
TDSAC_RS01315	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
TDSAC_RS01325	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
TDSAC_RS01330	COG0193	aminoacyl-tRNA hydrolase activity
TDSAC_RS01340	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
TDSAC_RS01340	COG0165	Argininosuccinate lyase
TDSAC_RS01345	COG0736	holo-[acyl-carrier-protein] synthase activity
TDSAC_RS01355	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
TDSAC_RS01360	COG0291	Belongs to the bacterial ribosomal protein bL35 family
TDSAC_RS01365	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
TDSAC_RS01370	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
TDSAC_RS01380	COG1966	Carbon starvation protein
TDSAC_RS01385	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
TDSAC_RS01390	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
TDSAC_RS01400	COG0719	Fe-S assembly protein
TDSAC_RS01405	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
TDSAC_RS01420	COG0543	2 iron, 2 sulfur cluster binding
TDSAC_RS01430	COG0590	tRNA wobble adenosine to inosine editing
TDSAC_RS01440	COG1388	LysM domain
TDSAC_RS01440	COG0791	NLP P60 protein
TDSAC_RS01445	COG0655	NAD(P)H dehydrogenase (quinone) activity
TDSAC_RS01450	COG0662	Cupin 2, conserved barrel domain protein
TDSAC_RS01450	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
TDSAC_RS01465	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
TDSAC_RS01475	COG1459	type II secretion system
TDSAC_RS01485	COG0432	Pfam Uncharacterised protein family UPF0047
TDSAC_RS01495	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
TDSAC_RS01500	COG0628	permease
TDSAC_RS01505	COG1012	belongs to the aldehyde dehydrogenase family
TDSAC_RS01510	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
TDSAC_RS01510	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
TDSAC_RS01520	COG1059	Responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine 7-oxoG) from DNA. Also nicks DNA at apurinic apyrimidinic sites (AP sites)
TDSAC_RS01525	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
TDSAC_RS01575	COG0248	Ppx GppA phosphatase
TDSAC_RS01580	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
TDSAC_RS01610	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
TDSAC_RS01615	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
TDSAC_RS01620	COG0542	response to heat
TDSAC_RS01625	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
TDSAC_RS01630	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
TDSAC_RS01640	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
TDSAC_RS01685	COG1929	Belongs to the glycerate kinase type-1 family
TDSAC_RS01690	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
TDSAC_RS01705	COG0475	glutathione-regulated potassium exporter activity
TDSAC_RS01715	COG0009	L-threonylcarbamoyladenylate synthase
TDSAC_RS01720	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
TDSAC_RS01735	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
TDSAC_RS01775	COG2814	Major facilitator Superfamily
TDSAC_RS01795	COG0662	Cupin 2, conserved barrel domain protein
TDSAC_RS01800	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
TDSAC_RS01850	COG1388	LysM domain
TDSAC_RS01850	COG3858	chitin binding
TDSAC_RS01900	COG1215	transferase activity, transferring glycosyl groups
TDSAC_RS01915	COG1216	Glycosyl transferase, family 2
TDSAC_RS01915	COG0438	transferase activity, transferring glycosyl groups
TDSAC_RS01970	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
TDSAC_RS01975	COG1850	ribulose-bisphosphate carboxylase activity
TDSAC_RS01980	COG0572	uridine kinase
TDSAC_RS01985	COG3959	Transketolase, thiamine diphosphate binding domain
TDSAC_RS01990	COG3958	Transketolase
TDSAC_RS01995	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
TDSAC_RS02000	COG0126	phosphoglycerate kinase activity
TDSAC_RS02005	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
TDSAC_RS02010	COG0698	ribose 5-phosphate isomerase
TDSAC_RS02015	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
TDSAC_RS02025	COG1937	Protein conserved in bacteria
TDSAC_RS02045	COG2217	Heavy metal translocating P-type atpase
TDSAC_RS02050	COG4443	Transcriptional Coactivator p15 (PC4)
TDSAC_RS02055	COG2814	Major facilitator Superfamily
TDSAC_RS02065	COG0417	DNA replication proofreading
TDSAC_RS02070	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
TDSAC_RS02085	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
TDSAC_RS02090	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
TDSAC_RS02095	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
TDSAC_RS02110	COG1592	Rubrerythrin
TDSAC_RS02130	COG0644	oxidoreductase
TDSAC_RS02155	COG2181	nitrate reductase activity
TDSAC_RS02155	COG0247	lactate metabolic process
TDSAC_RS02170	COG2878	Part of a membrane complex involved in electron transport
TDSAC_RS02175	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
TDSAC_RS02175	COG0493	'glutamate synthase
TDSAC_RS02185	COG0425	Belongs to the sulfur carrier protein TusA family
TDSAC_RS02185	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
TDSAC_RS02200	COG0739	heme binding
TDSAC_RS02205	COG0492	ferredoxin-NADP+ reductase activity
TDSAC_RS02235	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
TDSAC_RS02240	COG1570	exodeoxyribonuclease VII activity
TDSAC_RS02250	COG1227	inorganic diphosphatase activity
TDSAC_RS02255	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
TDSAC_RS02260	COG3956	TIGRFAM MazG family protein
TDSAC_RS02265	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
TDSAC_RS02275	COG1098	S1 RNA binding domain
TDSAC_RS02280	COG0137	argininosuccinate synthase activity
TDSAC_RS02285	COG0165	Argininosuccinate lyase
TDSAC_RS02295	COG0601	transmembrane transport
TDSAC_RS02310	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
TDSAC_RS02315	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
TDSAC_RS02320	COG1144	Oxidoreductase
TDSAC_RS02325	COG0674	pyruvate-flavodoxin oxidoreductase activity
TDSAC_RS02330	COG1013	pyruvate-flavodoxin oxidoreductase activity
TDSAC_RS02335	COG0352	thiamine-phosphate diphosphorylase activity
TDSAC_RS02345	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
TDSAC_RS02350	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
TDSAC_RS02355	COG0049	tRNA binding
TDSAC_RS02360	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
TDSAC_RS02370	COG0051	transcription antitermination factor activity, RNA binding
TDSAC_RS02375	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
TDSAC_RS02380	COG0088	Forms part of the polypeptide exit tunnel
TDSAC_RS02385	COG0089	rRNA binding
TDSAC_RS02390	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
TDSAC_RS02395	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
TDSAC_RS02405	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
TDSAC_RS02410	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
TDSAC_RS02415	COG0255	Belongs to the universal ribosomal protein uL29 family
TDSAC_RS02420	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
TDSAC_RS02425	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
TDSAC_RS02430	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
TDSAC_RS02440	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
TDSAC_RS02445	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
TDSAC_RS02450	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
TDSAC_RS02455	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
TDSAC_RS02460	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
TDSAC_RS02465	COG0200	Binds to the 23S rRNA
TDSAC_RS02480	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
TDSAC_RS02485	COG0257	Belongs to the bacterial ribosomal protein bL36 family
TDSAC_RS02490	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
TDSAC_RS02495	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
TDSAC_RS02500	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
TDSAC_RS02505	COG0202	RNA polymerase activity
TDSAC_RS02510	COG0203	ribosomal protein L17
TDSAC_RS02520	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
TDSAC_RS02525	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
TDSAC_RS02530	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
TDSAC_RS02535	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
TDSAC_RS02540	COG0588	phosphoglycerate mutase activity
TDSAC_RS02545	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
TDSAC_RS02550	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
TDSAC_RS02570	COG1902	pentaerythritol trinitrate reductase activity
TDSAC_RS02570	COG0446	pyridine nucleotide-disulphide oxidoreductase
TDSAC_RS02575	COG0267	Belongs to the bacterial ribosomal protein bL33 family
TDSAC_RS02585	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
TDSAC_RS02590	COG0250	Participates in transcription elongation, termination and antitermination
TDSAC_RS02595	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
TDSAC_RS02600	COG0081	regulation of translation
TDSAC_RS02605	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
TDSAC_RS02610	COG0222	ribosome binding
TDSAC_RS02615	COG0667	Aldo Keto reductase
TDSAC_RS02625	COG0840	transmembrane signaling receptor activity
TDSAC_RS02625	COG0840	transmembrane signaling receptor activity
TDSAC_RS02635	COG0631	protein serine/threonine phosphatase activity
TDSAC_RS02645	COG0028	Belongs to the TPP enzyme family
TDSAC_RS02650	COG0440	acetolactate synthase activity
TDSAC_RS02655	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
TDSAC_RS02660	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
TDSAC_RS02700	COG0438	transferase activity, transferring glycosyl groups
TDSAC_RS02710	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
TDSAC_RS02715	COG0613	PHP domain protein
TDSAC_RS02725	COG1260	myo-inositol-1-phosphate synthase
TDSAC_RS02735	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
TDSAC_RS02740	COG1185	polyribonucleotide nucleotidyltransferase activity
TDSAC_RS02745	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
TDSAC_RS02760	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
TDSAC_RS02765	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
TDSAC_RS02780	COG0356	it plays a direct role in the translocation of protons across the membrane
TDSAC_RS02795	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
TDSAC_RS02800	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
TDSAC_RS02805	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
TDSAC_RS02810	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
TDSAC_RS02815	COG0355	proton-transporting ATP synthase activity, rotational mechanism
TDSAC_RS02820	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
TDSAC_RS02830	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
TDSAC_RS02835	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
TDSAC_RS02840	COG0779	Required for maturation of 30S ribosomal subunits
TDSAC_RS02845	COG0195	Participates in both transcription termination and antitermination
TDSAC_RS02855	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
TDSAC_RS02855	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
TDSAC_RS02865	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
TDSAC_RS02880	COG0196	riboflavin kinase activity
TDSAC_RS02895	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
TDSAC_RS02905	COG0131	Imidazoleglycerol-phosphate dehydratase
TDSAC_RS02910	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
TDSAC_RS02915	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
TDSAC_RS02920	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
TDSAC_RS02925	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
TDSAC_RS02930	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
TDSAC_RS02935	COG0138	bifunctional purine biosynthesis protein purh
TDSAC_RS02940	COG0151	Belongs to the GarS family
TDSAC_RS02945	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
TDSAC_RS02955	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
TDSAC_RS02960	COG0154	amidase activity
TDSAC_RS02975	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
TDSAC_RS02985	COG1797	cobyrinic acid a,c-diamide synthase activity
TDSAC_RS03000	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
TDSAC_RS03005	COG3260	NADH ubiquinone oxidoreductase 20
TDSAC_RS03010	COG0651	ATP synthesis coupled electron transport
TDSAC_RS03015	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
TDSAC_RS03020	COG0437	4 iron, 4 sulfur cluster binding
TDSAC_RS03025	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
TDSAC_RS03025	COG3261	NADH dehydrogenase
TDSAC_RS03035	COG0649	NAD binding
TDSAC_RS03040	COG2814	Major facilitator Superfamily
TDSAC_RS03050	COG0385	Bile acid
TDSAC_RS03055	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
TDSAC_RS03060	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
TDSAC_RS03065	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
TDSAC_RS03075	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
TDSAC_RS03080	COG0071	Belongs to the small heat shock protein (HSP20) family
TDSAC_RS03090	COG0497	DNA recombination
TDSAC_RS03100	COG2001	Belongs to the MraZ family
TDSAC_RS03105	COG0275	rRNA processing
TDSAC_RS03115	COG0768	penicillin binding
TDSAC_RS03120	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
TDSAC_RS03125	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
TDSAC_RS03135	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
TDSAC_RS03140	COG0772	Belongs to the SEDS family
TDSAC_RS03145	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
TDSAC_RS03150	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
TDSAC_RS03155	COG0812	UDP-N-acetylmuramate dehydrogenase activity
TDSAC_RS03160	COG1181	Belongs to the D-alanine--D-alanine ligase family
TDSAC_RS03175	COG3856	small basic protein
TDSAC_RS03180	COG0849	cell division
TDSAC_RS03185	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
TDSAC_RS03195	COG1316	TRANSCRIPTIONal
TDSAC_RS03200	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
TDSAC_RS03210	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
TDSAC_RS03220	COG1077	Cell shape determining protein MreB Mrl
TDSAC_RS03235	COG0768	penicillin binding
TDSAC_RS03240	COG0850	regulation of cytokinetic process
TDSAC_RS03245	COG2894	cell division
TDSAC_RS03250	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
TDSAC_RS03255	COG0772	Belongs to the SEDS family
TDSAC_RS03265	COG1199	ATP-dependent helicase activity
TDSAC_RS03270	COG3885	ferrous iron binding
TDSAC_RS03270	COG2078	PFAM AMMECR1 domain protein
TDSAC_RS03280	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
TDSAC_RS03285	COG0072	phenylalanine-tRNA ligase activity
TDSAC_RS03285	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TDSAC_RS03295	COG1796	DNA polymerase
TDSAC_RS03295	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
TDSAC_RS03310	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
TDSAC_RS03315	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
TDSAC_RS03320	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
TDSAC_RS03325	COG0494	nUDIX hydrolase
TDSAC_RS03335	COG1012	belongs to the aldehyde dehydrogenase family
TDSAC_RS03340	COG0506	proline dehydrogenase activity
TDSAC_RS03380	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
TDSAC_RS03385	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
TDSAC_RS03395	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
TDSAC_RS03400	COG0750	zinc metalloprotease
TDSAC_RS03405	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
TDSAC_RS03410	COG0442	prolyl-tRNA aminoacylation
TDSAC_RS03415	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
TDSAC_RS03420	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
TDSAC_RS03425	COG0375	protein maturation
TDSAC_RS03445	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
TDSAC_RS03455	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
TDSAC_RS03460	COG0505	Belongs to the CarA family
TDSAC_RS03465	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
TDSAC_RS03475	COG0037	tRNA processing
TDSAC_RS03480	COG1811	Na channel or pump
TDSAC_RS03485	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
TDSAC_RS03490	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
TDSAC_RS03495	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
TDSAC_RS03500	COG1045	serine acetyltransferase
TDSAC_RS03505	COG0215	cysteine-tRNA ligase activity
TDSAC_RS03510	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
TDSAC_RS03520	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
TDSAC_RS03545	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
TDSAC_RS03550	COG0287	Prephenate dehydrogenase
TDSAC_RS03555	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
TDSAC_RS03560	COG0617	tRNA 3'-terminal CCA addition
TDSAC_RS03570	COG0446	pyridine nucleotide-disulphide oxidoreductase
TDSAC_RS03575	COG1193	negative regulation of DNA recombination
TDSAC_RS03590	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
TDSAC_RS03595	COG3854	ATPases associated with a variety of cellular activities
TDSAC_RS03600	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
TDSAC_RS03605	COG0470	DNA polymerase III
TDSAC_RS03610	COG1774	PSP1 C-terminal conserved region
TDSAC_RS03640	COG1278	Cold shock
TDSAC_RS03645	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
TDSAC_RS03650	COG0653	protein targeting
TDSAC_RS03665	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
TDSAC_RS03670	COG3959	Transketolase, thiamine diphosphate binding domain
TDSAC_RS03675	COG3958	Transketolase
TDSAC_RS03680	COG2884	Cell division ATP-binding protein ftsE
TDSAC_RS03685	COG2177	Part of the ABC transporter FtsEX involved in
TDSAC_RS03690	COG1573	uracil-dna glycosylase
TDSAC_RS03705	COG0564	pseudouridine synthase activity
TDSAC_RS03715	COG1635	Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur
TDSAC_RS03730	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
TDSAC_RS03775	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
TDSAC_RS03780	COG0066	3-isopropylmalate dehydratase activity
TDSAC_RS03790	COG0674	pyruvate-flavodoxin oxidoreductase activity
TDSAC_RS03790	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
TDSAC_RS03795	COG1013	pyruvate-flavodoxin oxidoreductase activity
TDSAC_RS03810	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
TDSAC_RS03820	COG0409	Hydrogenase expression formation protein
TDSAC_RS03825	COG0298	carbon dioxide binding
TDSAC_RS03830	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
TDSAC_RS03835	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
TDSAC_RS03855	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
TDSAC_RS03860	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
TDSAC_RS03880	COG1139	Iron-sulfur cluster binding protein
TDSAC_RS03885	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TDSAC_RS03900	COG1522	sequence-specific DNA binding
TDSAC_RS03950	COG4632	Exopolysaccharide biosynthesis protein
TDSAC_RS03950	COG5434	Belongs to the glycosyl hydrolase 28 family
TDSAC_RS03980	COG1122	ATPase activity
TDSAC_RS03990	COG0310	cobalt ion transport
TDSAC_RS04070	COG0444	Belongs to the ABC transporter superfamily
TDSAC_RS04080	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
TDSAC_RS04085	COG0546	phosphoglycolate phosphatase activity
TDSAC_RS04110	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
TDSAC_RS04115	COG1297	OPT oligopeptide transporter protein
TDSAC_RS04130	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
TDSAC_RS04135	COG1074	ATP-dependent DNA helicase activity
TDSAC_RS04150	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
TDSAC_RS04155	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TDSAC_RS04160	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
TDSAC_RS04160	COG2050	protein possibly involved in aromatic compounds catabolism
TDSAC_RS04185	COG2759	Belongs to the formate--tetrahydrofolate ligase family
TDSAC_RS04190	COG2814	Major facilitator Superfamily
TDSAC_RS04200	COG0242	peptide deformylase activity
TDSAC_RS04205	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
TDSAC_RS04215	COG0820	rRNA (adenine-C2-)-methyltransferase activity
TDSAC_RS04220	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
TDSAC_RS04220	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
TDSAC_RS04225	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
TDSAC_RS04225	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
TDSAC_RS04230	COG0460	homoserine dehydrogenase
TDSAC_RS04240	COG0497	DNA recombination
TDSAC_RS04245	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
TDSAC_RS04250	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
TDSAC_RS04255	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
TDSAC_RS04260	COG0142	geranyltranstransferase activity
TDSAC_RS04265	COG1196	nuclear chromosome segregation
TDSAC_RS04280	COG0552	protein localization to endoplasmic reticulum
TDSAC_RS04285	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
TDSAC_RS04290	COG0228	four-way junction DNA binding
TDSAC_RS04295	COG1837	Belongs to the UPF0109 family
TDSAC_RS04300	COG0336	Belongs to the RNA methyltransferase TrmD family
TDSAC_RS04305	COG0335	large ribosomal subunit rRNA binding
TDSAC_RS04310	COG0681	Belongs to the peptidase S26 family
TDSAC_RS04315	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
TDSAC_RS04320	COG0792	nuclease activity
TDSAC_RS04325	COG0606	chelatase, subunit chli
TDSAC_RS04330	COG0758	DNA mediated transformation
TDSAC_RS04335	COG0445	tRNA wobble uridine modification
TDSAC_RS04340	COG0720	synthase
TDSAC_RS04345	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
TDSAC_RS04355	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
TDSAC_RS04355	COG1648	precorrin-2 dehydrogenase activity
TDSAC_RS04360	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
TDSAC_RS04370	COG0181	hydroxymethylbilane synthase activity
TDSAC_RS04380	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
TDSAC_RS04385	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
TDSAC_RS04400	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TDSAC_RS04405	COG0303	'Molybdopterin
TDSAC_RS04410	COG1910	domain protein
TDSAC_RS04415	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
TDSAC_RS04420	COG0315	cyclic pyranopterin monophosphate synthase activity
TDSAC_RS04425	COG0521	Mo-molybdopterin cofactor biosynthetic process
TDSAC_RS04440	COG0284	orotidine-5'-phosphate decarboxylase activity
TDSAC_RS04465	COG0483	inositol monophosphate 1-phosphatase activity
TDSAC_RS04480	COG2414	aldehyde ferredoxin oxidoreductase
TDSAC_RS04485	COG1139	Iron-sulfur cluster binding protein
TDSAC_RS04495	COG2271	Major facilitator Superfamily
TDSAC_RS04530	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
TDSAC_RS04535	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
TDSAC_RS04540	COG0436	Aminotransferase
TDSAC_RS04580	COG3706	GGDEF domain
TDSAC_RS04585	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
TDSAC_RS04590	COG0655	NAD(P)H dehydrogenase (quinone) activity
TDSAC_RS04605	COG1331	Highly conserved protein containing a thioredoxin domain
TDSAC_RS04615	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
TDSAC_RS04620	COG1687	branched-chain amino acid
TDSAC_RS04625	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
TDSAC_RS04630	COG2814	Major facilitator Superfamily
TDSAC_RS04660	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
TDSAC_RS04670	COG1473	amidohydrolase
TDSAC_RS04675	COG0252	asparaginase activity
TDSAC_RS04685	COG2199	diguanylate cyclase activity
TDSAC_RS04705	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
TDSAC_RS04710	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
TDSAC_RS04715	COG0305	Participates in initiation and elongation during chromosome replication
TDSAC_RS04730	COG0067	glutamate synthase
TDSAC_RS04760	COG0535	radical SAM domain protein
TDSAC_RS04765	COG1013	pyruvate-flavodoxin oxidoreductase activity
TDSAC_RS04780	COG2255	four-way junction helicase activity
TDSAC_RS04785	COG0632	four-way junction helicase activity
TDSAC_RS04790	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
TDSAC_RS04795	COG0217	transcriptional regulatory protein
TDSAC_RS04800	COG0756	dUTP diphosphatase activity
TDSAC_RS04805	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
TDSAC_RS04810	COG0268	Binds directly to 16S ribosomal RNA
TDSAC_RS04820	COG0658	competence protein
TDSAC_RS04825	COG1596	polysaccharide export
TDSAC_RS04825	COG1555	photosystem II stabilization
TDSAC_RS04830	COG0495	leucyl-tRNA aminoacylation
TDSAC_RS04840	COG5001	Diguanylate cyclase
TDSAC_RS04840	COG3300	MHYT domain
TDSAC_RS04880	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
TDSAC_RS04895	COG1064	alcohol dehydrogenase
TDSAC_RS04920	COG0277	FAD linked oxidase domain protein
TDSAC_RS04925	COG3260	NADH ubiquinone oxidoreductase 20
TDSAC_RS04930	COG3261	NADH dehydrogenase
TDSAC_RS04930	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
TDSAC_RS04935	COG0651	ATP synthesis coupled electron transport
TDSAC_RS04950	COG0651	ATP synthesis coupled electron transport
TDSAC_RS04960	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
TDSAC_RS04965	COG2244	polysaccharide biosynthetic process
TDSAC_RS04980	COG0859	PFAM glycosyl transferase family 9
TDSAC_RS04995	COG1968	undecaprenyl-diphosphatase activity
TDSAC_RS05010	COG0463	Glycosyl transferase, family 2
TDSAC_RS05015	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
TDSAC_RS05020	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
TDSAC_RS05070	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
TDSAC_RS05075	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
TDSAC_RS05080	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
TDSAC_RS05085	COG2205	protein histidine kinase activity
TDSAC_RS05090	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
TDSAC_RS05095	COG2814	Major facilitator Superfamily
TDSAC_RS05110	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
TDSAC_RS05115	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
TDSAC_RS05125	COG1027	Aspartate ammonia-lyase
TDSAC_RS05140	COG4624	Iron only hydrogenase large subunit, C-terminal domain
TDSAC_RS05140	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
TDSAC_RS05170	COG1278	Cold shock
TDSAC_RS05195	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
TDSAC_RS05205	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
TDSAC_RS05215	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
TDSAC_RS05220	COG1872	DUF167
TDSAC_RS05230	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
TDSAC_RS05235	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
TDSAC_RS05240	COG0556	nucleotide-excision repair
TDSAC_RS05245	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TDSAC_RS05270	COG0121	glutamine amidotransferase
TDSAC_RS05290	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
TDSAC_RS05290	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
TDSAC_RS05300	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
TDSAC_RS05310	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
TDSAC_RS05315	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
TDSAC_RS05320	COG1758	RNA polymerase activity
TDSAC_RS05325	COG0194	GDP metabolic process
TDSAC_RS05335	COG0542	response to heat
TDSAC_RS05340	COG0789	Transcriptional regulator
TDSAC_RS05345	COG0484	heat shock protein binding
TDSAC_RS05350	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
TDSAC_RS05355	COG0443	Heat shock 70 kDa protein
TDSAC_RS05360	COG0822	iron-sulfur transferase activity
TDSAC_RS05370	COG1132	(ABC) transporter
TDSAC_RS05395	COG1921	L-seryl-tRNASec selenium transferase activity
TDSAC_RS05410	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
TDSAC_RS05440	COG3300	MHYT domain
TDSAC_RS05440	COG5001	Diguanylate cyclase
TDSAC_RS05445	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
TDSAC_RS05455	COG3706	GGDEF domain
TDSAC_RS05465	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TDSAC_RS05475	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
TDSAC_RS05495	COG1136	(ABC) transporter
TDSAC_RS05495	COG0577	efflux transmembrane transporter activity
TDSAC_RS05500	COG1136	(ABC) transporter
TDSAC_RS05500	COG0577	efflux transmembrane transporter activity
TDSAC_RS05505	COG0577	efflux transmembrane transporter activity
TDSAC_RS05505	COG1136	(ABC) transporter
TDSAC_RS05515	COG0437	4 iron, 4 sulfur cluster binding
TDSAC_RS05535	COG0437	4 iron, 4 sulfur cluster binding
TDSAC_RS05550	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
TDSAC_RS05555	COG0095	Lipoate-protein ligase
TDSAC_RS05560	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
TDSAC_RS05565	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
TDSAC_RS05570	COG0509	glycine decarboxylation via glycine cleavage system
TDSAC_RS05580	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
TDSAC_RS05585	COG1490	D-aminoacyl-tRNA deacylase activity
TDSAC_RS05590	COG0167	dihydroorotate dehydrogenase activity
TDSAC_RS05605	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
TDSAC_RS05610	COG4399	Belongs to the UPF0754 family
TDSAC_RS05630	COG0497	DNA recombination
TDSAC_RS05640	COG0697	spore germination
TDSAC_RS05650	COG0860	N-Acetylmuramoyl-L-alanine amidase
TDSAC_RS05650	COG2247	cell wall binding repeat
TDSAC_RS05700	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
TDSAC_RS05710	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
TDSAC_RS05710	COG0731	radical SAM domain protein
TDSAC_RS05715	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
TDSAC_RS05720	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
TDSAC_RS05745	COG2193	ferroxidase activity
TDSAC_RS05755	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
TDSAC_RS05760	COG0066	3-isopropylmalate dehydratase activity
TDSAC_RS05765	COG0473	3-isopropylmalate dehydrogenase activity
TDSAC_RS05770	COG1210	Utp--glucose-1-phosphate uridylyltransferase
TDSAC_RS05790	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
TDSAC_RS05795	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
TDSAC_RS05800	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
TDSAC_RS05810	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
TDSAC_RS05820	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
TDSAC_RS05830	COG0740	serine-type endopeptidase activity
TDSAC_RS05835	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
TDSAC_RS05860	COG3300	MHYT domain
TDSAC_RS05860	COG5001	Diguanylate cyclase
TDSAC_RS05865	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
TDSAC_RS05870	COG0708	Exodeoxyribonuclease III
TDSAC_RS05880	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
TDSAC_RS05885	COG1522	sequence-specific DNA binding
TDSAC_RS05890	COG0535	radical SAM domain protein
TDSAC_RS05895	COG0113	porphobilinogen synthase activity
TDSAC_RS05900	COG0535	radical SAM domain protein
TDSAC_RS05905	COG0489	protein tyrosine kinase activity
TDSAC_RS05910	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
TDSAC_RS05930	COG0037	tRNA processing
TDSAC_RS05950	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
TDSAC_RS05950	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
TDSAC_RS05955	COG4956	integral membrane protein (PIN domain superfamily)
TDSAC_RS05960	COG0815	Transfers the fatty acyl group on membrane lipoproteins
TDSAC_RS05990	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
TDSAC_RS05995	COG0220	tRNA (guanine-N7-)-methyltransferase activity
TDSAC_RS05995	COG2890	protein-(glutamine-N5) methyltransferase activity
TDSAC_RS06000	COG1802	Transcriptional regulator
TDSAC_RS06010	COG0805	protein transport
TDSAC_RS06020	COG1546	Belongs to the CinA family
TDSAC_RS06020	COG1058	Belongs to the CinA family
TDSAC_RS06035	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
TDSAC_RS06045	COG0180	Tryptophanyl-tRNA synthetase
TDSAC_RS06055	COG1994	Peptidase M50
TDSAC_RS06060	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
TDSAC_RS06060	COG3620	sequence-specific DNA binding
TDSAC_RS06060	COG0617	tRNA 3'-terminal CCA addition
TDSAC_RS06065	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
TDSAC_RS06080	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
TDSAC_RS06085	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
TDSAC_RS06090	COG2848	UPF0210 protein
TDSAC_RS06100	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
TDSAC_RS06105	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TDSAC_RS06135	COG2814	Major facilitator Superfamily
TDSAC_RS06135	COG0477	Major facilitator Superfamily
TDSAC_RS06140	COG4178	(ABC) transporter
TDSAC_RS06150	COG3681	Belongs to the UPF0597 family
TDSAC_RS06155	COG2902	Dehydrogenase
TDSAC_RS06160	COG0251	oxidation-reduction process
TDSAC_RS06165	COG1760	l-serine dehydratase
TDSAC_RS06170	COG1760	l-serine dehydratase
TDSAC_RS06180	COG0148	phosphopyruvate hydratase activity
TDSAC_RS06185	COG0725	ABC transporter, periplasmic molybdate-binding protein
TDSAC_RS06190	COG4149	molybdate abc transporter
TDSAC_RS06195	COG3842	ATPase activity
TDSAC_RS06210	COG0735	belongs to the Fur family
TDSAC_RS06260	COG0519	Catalyzes the synthesis of GMP from XMP
TDSAC_RS06260	COG0518	GMP synthase (glutamine-hydrolyzing) activity
TDSAC_RS06265	COG0516	GMP reductase activity
TDSAC_RS06270	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
TDSAC_RS06275	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
TDSAC_RS06275	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
TDSAC_RS06280	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
TDSAC_RS06280	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
TDSAC_RS06285	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
TDSAC_RS06290	COG0438	transferase activity, transferring glycosyl groups
TDSAC_RS06295	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TDSAC_RS06300	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
TDSAC_RS06305	COG0085	RNA polymerase activity
TDSAC_RS06310	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
TDSAC_RS06335	COG0668	transmembrane transport
TDSAC_RS06340	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
TDSAC_RS06360	COG3328	transposase activity
TDSAC_RS06365	COG1454	alcohol dehydrogenase
TDSAC_RS06385	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TDSAC_RS06395	COG0484	heat shock protein binding
TDSAC_RS06400	COG1420	regulation of RNA biosynthetic process
TDSAC_RS06405	COG0129	dihydroxy-acid dehydratase activity
TDSAC_RS06410	COG0799	negative regulation of ribosome biogenesis
TDSAC_RS06420	COG0227	Belongs to the bacterial ribosomal protein bL28 family
TDSAC_RS06460	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
TDSAC_RS06465	COG3259	Nickel-dependent hydrogenase
TDSAC_RS06500	COG0525	valine-tRNA ligase activity
TDSAC_RS06505	COG0285	dihydrofolate synthase activity
TDSAC_RS06510	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TDSAC_RS06510	COG0730	response to heat
TDSAC_RS06520	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
TDSAC_RS06530	COG0140	phosphoribosyl-ATP diphosphatase activity
TDSAC_RS06530	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
TDSAC_RS06535	COG0233	cytoplasmic translational termination
TDSAC_RS06540	COG0528	UMP kinase activity
TDSAC_RS06545	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
TDSAC_RS06550	COG0052	Belongs to the universal ribosomal protein uS2 family
TDSAC_RS06565	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
TDSAC_RS06575	COG0628	permease
TDSAC_RS06580	COG1131	(ABC) transporter
TDSAC_RS06590	COG0825	malonyl-CoA metabolic process
TDSAC_RS06595	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
TDSAC_RS06605	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
TDSAC_RS06610	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
TDSAC_RS06625	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
TDSAC_RS06630	COG0211	Belongs to the bacterial ribosomal protein bL27 family
TDSAC_RS06635	COG0261	This protein binds to 23S rRNA in the presence of protein L20
TDSAC_RS06655	COG2221	Nitrite and sulphite reductase 4Fe-4S
TDSAC_RS06660	COG2221	Nitrite and sulphite reductase 4Fe-4S
TDSAC_RS06665	COG2920	part of a sulfur-relay system
TDSAC_RS06670	COG0247	lactate metabolic process
TDSAC_RS06680	COG0037	tRNA processing
TDSAC_RS06685	COG0482	sulfurtransferase activity
TDSAC_RS06690	COG3118	belongs to the thioredoxin family
TDSAC_RS06695	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
TDSAC_RS06700	COG0210	DNA helicase
TDSAC_RS06705	COG0124	histidyl-tRNA synthetase
TDSAC_RS06710	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
TDSAC_RS06730	COG4604	ABC transporter, ATP-binding protein
TDSAC_RS06735	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TDSAC_RS06740	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
TDSAC_RS06750	COG2084	Dehydrogenase
TDSAC_RS06755	COG0765	amino acid transport
TDSAC_RS06760	COG0765	amino acid transport
TDSAC_RS06765	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
TDSAC_RS06770	COG1126	abc transporter atp-binding protein
TDSAC_RS06775	COG0640	Transcriptional regulator
TDSAC_RS06780	COG1132	(ABC) transporter
TDSAC_RS06785	COG1519	Transferase
TDSAC_RS06790	COG1663	tetraacyldisaccharide 4'-kinase activity
TDSAC_RS06795	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
TDSAC_RS06805	COG0793	Belongs to the peptidase S41A family
TDSAC_RS06805	COG3409	Peptidoglycan-binding domain 1 protein
TDSAC_RS06825	COG1940	carbohydrate kinase activity
TDSAC_RS06875	COG0385	Bile acid
TDSAC_RS06880	COG1720	tRNA m6t6A37 methyltransferase activity
TDSAC_RS06890	COG0848	biopolymer transport protein
TDSAC_RS06895	COG0811	peptide transport
TDSAC_RS06910	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
TDSAC_RS06940	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
TDSAC_RS06945	COG0857	belongs to the CobB CobQ family
TDSAC_RS06950	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
TDSAC_RS06950	COG0045	succinate-CoA ligase (ADP-forming) activity
TDSAC_RS06950	COG1042	CoA-binding domain protein
TDSAC_RS06955	COG0277	FAD linked oxidase domain protein
TDSAC_RS06965	COG0277	FAD linked oxidase domain protein
TDSAC_RS06970	COG2226	methyltransferase
TDSAC_RS06975	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
TDSAC_RS06985	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
TDSAC_RS06995	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
TDSAC_RS07000	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
TDSAC_RS07005	COG0416	fatty acid biosynthetic process
TDSAC_RS07010	COG0333	Belongs to the bacterial ribosomal protein bL32 family
TDSAC_RS07025	COG0501	Belongs to the peptidase M48B family
TDSAC_RS07030	COG1902	pentaerythritol trinitrate reductase activity
TDSAC_RS07040	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
TDSAC_RS07050	COG0531	amino acid
TDSAC_RS07055	COG2271	Major facilitator Superfamily
TDSAC_RS07075	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
TDSAC_RS07080	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
TDSAC_RS07100	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
TDSAC_RS07110	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TDSAC_RS07120	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
TDSAC_RS07130	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
TDSAC_RS07150	COG0745	RESPONSE REGULATOR receiver
TDSAC_RS07180	COG1918	ferrous iron import across plasma membrane
TDSAC_RS07180	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
TDSAC_RS07190	COG0602	queuosine metabolic process
TDSAC_RS07195	COG0720	synthase
TDSAC_RS07210	COG0670	Belongs to the BI1 family
TDSAC_RS07235	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
TDSAC_RS07240	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
TDSAC_RS07250	COG0704	Plays a role in the regulation of phosphate uptake
TDSAC_RS07255	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
TDSAC_RS07260	COG0581	inorganic phosphate transmembrane transporter activity
TDSAC_RS07265	COG0573	inorganic phosphate transmembrane transporter activity
TDSAC_RS07285	COG0232	Belongs to the dGTPase family. Type 2 subfamily
TDSAC_RS07290	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
TDSAC_RS07290	COG0574	Belongs to the PEP-utilizing enzyme family
TDSAC_RS07295	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
TDSAC_RS07300	COG0751	glycine-tRNA ligase activity
TDSAC_RS07305	COG0752	glycyl-tRNA synthetase alpha subunit
TDSAC_RS07310	COG1215	transferase activity, transferring glycosyl groups
TDSAC_RS07320	COG2814	Major facilitator Superfamily
TDSAC_RS07335	COG0504	CTP synthase activity
TDSAC_RS07340	COG1253	flavin adenine dinucleotide binding
TDSAC_RS07345	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
TDSAC_RS07350	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
TDSAC_RS07355	COG1480	7TM receptor with intracellular HD hydrolase
TDSAC_RS07360	COG0828	Belongs to the bacterial ribosomal protein bS21 family
TDSAC_RS07365	COG0537	adenosine 5'-monophosphoramidase activity
TDSAC_RS07390	COG0791	NLP P60 protein
TDSAC_RS07390	COG3883	PFAM NLP P60 protein
TDSAC_RS07400	COG0586	Pfam SNARE associated Golgi protein
TDSAC_RS07410	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
TDSAC_RS07415	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
TDSAC_RS07420	COG0254	rRNA binding
TDSAC_RS07430	COG1294	oxidase, subunit
TDSAC_RS07435	COG1271	oxidase subunit
TDSAC_RS07440	COG4106	trans-aconitate 2-methyltransferase activity
TDSAC_RS07445	COG1342	Belongs to the UPF0251 family
TDSAC_RS07455	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
TDSAC_RS07460	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
TDSAC_RS07470	COG0513	Belongs to the DEAD box helicase family
TDSAC_RS07490	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
TDSAC_RS07490	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
TDSAC_RS07500	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
TDSAC_RS07510	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
TDSAC_RS07525	COG2909	trisaccharide binding
TDSAC_RS07540	COG1131	(ABC) transporter
TDSAC_RS07545	COG1131	(ABC) transporter
TDSAC_RS07560	COG0842	Transport permease protein
TDSAC_RS07605	COG2197	response regulator
TDSAC_RS07610	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
TDSAC_RS07625	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
TDSAC_RS07635	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
TDSAC_RS07645	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
TDSAC_RS07660	COG1620	l-lactate permease
TDSAC_RS07720	COG0439	Biotin carboxylase
TDSAC_RS07725	COG0511	ligase activity, forming carbon-carbon bonds
TDSAC_RS07730	COG1151	hydroxylamine reductase activity
TDSAC_RS07735	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
TDSAC_RS07740	COG0733	neurotransmitter:sodium symporter activity
TDSAC_RS07750	COG1966	Carbon starvation protein
TDSAC_RS07770	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
TDSAC_RS07785	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
TDSAC_RS07790	COG1233	COG1233 Phytoene dehydrogenase and related
TDSAC_RS07810	COG2046	Belongs to the sulfate adenylyltransferase family
TDSAC_RS07815	COG0563	adenylate kinase activity
TDSAC_RS07820	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
TDSAC_RS07825	COG1164	Oligoendopeptidase f
TDSAC_RS07845	COG0489	protein tyrosine kinase activity
TDSAC_RS07850	COG1342	Belongs to the UPF0251 family
TDSAC_RS07855	COG2059	Chromate
TDSAC_RS07870	COG0840	transmembrane signaling receptor activity
TDSAC_RS07880	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
TDSAC_RS07915	COG1660	Displays ATPase and GTPase activities
TDSAC_RS07920	COG0391	Required for morphogenesis under gluconeogenic growth conditions
TDSAC_RS07930	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
TDSAC_RS07935	COG0126	phosphoglycerate kinase activity
TDSAC_RS07940	COG0149	triose-phosphate isomerase activity
TDSAC_RS07945	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
TDSAC_RS07955	COG1304	FMN binding
TDSAC_RS07975	COG1584	GPR1 FUN34 yaaH family protein
TDSAC_RS07980	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TDSAC_RS07990	COG1137	ATPase activity
TDSAC_RS07995	COG0571	ribonuclease III activity
TDSAC_RS08000	COG1984	allophanate hydrolase subunit 2
TDSAC_RS08005	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
TDSAC_RS08010	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
TDSAC_RS08015	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
TDSAC_RS08020	COG1605	Chorismate mutase
TDSAC_RS08020	COG0077	Prephenate dehydratase
TDSAC_RS08050	COG0489	protein tyrosine kinase activity
TDSAC_RS08055	COG2894	cell division
TDSAC_RS08060	COG2204	response regulator
TDSAC_RS08075	COG1515	deoxyribonuclease V activity
TDSAC_RS08080	COG1763	Mo-molybdopterin cofactor biosynthetic process
TDSAC_RS08090	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
TDSAC_RS08095	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
TDSAC_RS08100	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
TDSAC_RS08105	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
TDSAC_RS08115	COG0438	transferase activity, transferring glycosyl groups
TDSAC_RS08120	COG3660	Nucleoside-diphosphate-sugar epimerase
TDSAC_RS08125	COG0750	zinc metalloprotease
TDSAC_RS08140	COG0730	response to heat
TDSAC_RS08160	COG2197	response regulator
TDSAC_RS08180	COG0546	phosphoglycolate phosphatase activity
TDSAC_RS08185	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
TDSAC_RS08190	COG0004	ammonium transporteR
TDSAC_RS08195	COG0347	Belongs to the P(II) protein family
TDSAC_RS08205	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
TDSAC_RS08215	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
TDSAC_RS08220	COG1766	The M ring may be actively involved in energy transduction
TDSAC_RS08230	COG1558	bacterial-type flagellum-dependent cell motility
TDSAC_RS08235	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
TDSAC_RS08245	COG4786	Flagellar basal body rod
TDSAC_RS08245	COG1256	bacterial-type flagellum assembly
TDSAC_RS08270	COG1706	bacterial-type flagellum-dependent cell motility
TDSAC_RS08275	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
TDSAC_RS08290	COG4786	Flagellar basal body rod
TDSAC_RS08315	COG5002	protein histidine kinase activity
TDSAC_RS08315	COG3850	Histidine kinase
TDSAC_RS08320	COG0745	RESPONSE REGULATOR receiver
TDSAC_RS08325	COG0840	transmembrane signaling receptor activity
TDSAC_RS08325	COG3290	protein histidine kinase activity
TDSAC_RS08335	COG2855	membrane
TDSAC_RS08340	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
TDSAC_RS08345	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
TDSAC_RS08355	COG0693	protein deglycase activity
TDSAC_RS08365	COG2239	Acts as a magnesium transporter
TDSAC_RS08375	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
TDSAC_RS08385	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TDSAC_RS08390	COG1451	nucleotide metabolic process
TDSAC_RS08430	COG1321	iron dependent repressor
TDSAC_RS08435	COG1007	ATP synthesis coupled electron transport
TDSAC_RS08445	COG0651	ATP synthesis coupled electron transport
TDSAC_RS08455	COG0651	ATP synthesis coupled electron transport
TDSAC_RS08460	COG0713	ATP synthesis coupled electron transport
TDSAC_RS08465	COG0839	Belongs to the complex I subunit 6 family
TDSAC_RS08470	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
TDSAC_RS08475	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TDSAC_RS08480	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TDSAC_RS08485	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TDSAC_RS08490	COG0649	NAD binding
TDSAC_RS08495	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TDSAC_RS08500	COG0437	4 iron, 4 sulfur cluster binding
TDSAC_RS08510	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
TDSAC_RS08515	COG0840	transmembrane signaling receptor activity
TDSAC_RS08530	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
TDSAC_RS08550	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
TDSAC_RS08555	COG0501	Belongs to the peptidase M48B family
TDSAC_RS08565	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
TDSAC_RS08570	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
TDSAC_RS08605	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
TDSAC_RS08610	COG0616	signal peptide processing
TDSAC_RS08635	COG2814	Major facilitator Superfamily
TDSAC_RS08645	COG0589	response to stress
TDSAC_RS08660	COG0330	HflC and HflK could
TDSAC_RS08690	COG1918	ferrous iron import across plasma membrane
TDSAC_RS08690	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
TDSAC_RS08700	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
TDSAC_RS08725	COG1546	Belongs to the CinA family
TDSAC_RS08725	COG1058	Belongs to the CinA family
TDSAC_RS08730	COG0303	'Molybdopterin
TDSAC_RS08735	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
TDSAC_RS08745	COG1254	Belongs to the acylphosphatase family
TDSAC_RS08750	COG1776	CheC inhibitor of MCP methylation
TDSAC_RS08750	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
TDSAC_RS08755	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
TDSAC_RS08765	COG1582	Flagellar protein (FlbD)
TDSAC_RS08795	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
TDSAC_RS08825	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
TDSAC_RS08845	COG0156	8-amino-7-oxononanoate synthase activity
TDSAC_RS08850	COG0105	UTP biosynthetic process
TDSAC_RS08855	COG1475	DNA binding
TDSAC_RS08860	COG1192	Involved in chromosome partitioning
TDSAC_RS08875	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
TDSAC_RS08880	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
TDSAC_RS08880	COG0512	Glutamine amidotransferase of anthranilate synthase
TDSAC_RS08885	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
TDSAC_RS08895	COG0135	phosphoribosylanthranilate isomerase activity
TDSAC_RS08900	COG0133	tryptophan synthase activity
TDSAC_RS08905	COG0159	tryptophan synthase activity
TDSAC_RS08910	COG0516	GMP reductase activity
TDSAC_RS08910	COG0517	IMP dehydrogenase activity
TDSAC_RS08920	COG4149	molybdate abc transporter
TDSAC_RS08925	COG0725	ABC transporter, periplasmic molybdate-binding protein
TDSAC_RS08940	COG0357	Ribosomal RNA small subunit methyltransferase G
TDSAC_RS08950	COG0706	membrane insertase activity
TDSAC_RS08955	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
TDSAC_RS08965	COG0230	Belongs to the bacterial ribosomal protein bL34 family