locus-tag	class	description
THENA_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
THENA_RS00010	COG0592	DNA-directed DNA polymerase activity
THENA_RS00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
THENA_RS00025	COG0187	DNA topoisomerase II activity
THENA_RS00030	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
THENA_RS00035	COG0142	geranyltranstransferase activity
THENA_RS00045	COG1191	sigma factor activity
THENA_RS00060	COG1360	Flagellar Motor Protein
THENA_RS00070	COG2201	protein-glutamate methylesterase activity
THENA_RS00080	COG1338	Plays a role in the flagellum-specific transport system
THENA_RS00085	COG2201	protein-glutamate methylesterase activity
THENA_RS00090	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
THENA_RS00095	COG1776	CheC inhibitor of MCP methylation
THENA_RS00100	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
THENA_RS00105	COG1987	bacterial-type flagellum assembly
THENA_RS00115	COG1684	flagellar biosynthetic protein fliR
THENA_RS00120	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
THENA_RS00145	COG0643	Histidine kinase
THENA_RS00145	COG2198	Histidine kinase
THENA_RS00155	COG1815	bacterial-type flagellum-dependent cell motility
THENA_RS00160	COG0741	lytic transglycosylase activity
THENA_RS00165	COG5001	Diguanylate cyclase
THENA_RS00165	COG3300	MHYT domain
THENA_RS00170	COG2223	nitrite transmembrane transporter activity
THENA_RS00185	COG1151	hydroxylamine reductase activity
THENA_RS00195	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
THENA_RS00220	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
THENA_RS00225	COG0459	protein refolding
THENA_RS00230	COG3290	protein histidine kinase activity
THENA_RS00230	COG0840	transmembrane signaling receptor activity
THENA_RS00235	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
THENA_RS00250	COG0405	Gamma-glutamyltransferase
THENA_RS00255	COG0277	FAD linked oxidase domain protein
THENA_RS00260	COG0450	alkyl hydroperoxide reductase
THENA_RS00280	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
THENA_RS00290	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
THENA_RS00305	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
THENA_RS00310	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
THENA_RS00315	COG2877	3-deoxy-8-phosphooctulonate synthase activity
THENA_RS00320	COG0517	IMP dehydrogenase activity
THENA_RS00320	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
THENA_RS00325	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
THENA_RS00335	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
THENA_RS00360	COG1067	ATP-dependent peptidase activity
THENA_RS00440	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
THENA_RS00450	COG0826	peptidase U32
THENA_RS00455	COG0419	ATPase involved in DNA repair
THENA_RS00460	COG0420	3'-5' exonuclease activity
THENA_RS00470	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
THENA_RS00475	COG1140	nitrate reductase beta subunit
THENA_RS00485	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
THENA_RS00490	COG2181	nitrate reductase activity
THENA_RS00495	COG0426	domain, Protein
THENA_RS00515	COG2226	methyltransferase
THENA_RS00525	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
THENA_RS00530	COG0644	oxidoreductase
THENA_RS00540	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
THENA_RS00585	COG0067	glutamate synthase
THENA_RS00585	COG0069	glutamate synthase activity
THENA_RS00585	COG0070	glutamate synthase
THENA_RS00590	COG0493	'glutamate synthase
THENA_RS00595	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
THENA_RS00600	COG0511	ligase activity, forming carbon-carbon bonds
THENA_RS00605	COG0439	Biotin carboxylase
THENA_RS00610	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
THENA_RS00615	COG0107	imidazoleglycerol-phosphate synthase activity
THENA_RS00620	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
THENA_RS00635	COG1160	GTP binding
THENA_RS00640	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
THENA_RS00645	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
THENA_RS00665	COG0859	PFAM glycosyl transferase family 9
THENA_RS00700	COG2033	superoxide reductase activity
THENA_RS00710	COG5298	Protein conserved in bacteria
THENA_RS00730	COG0497	DNA recombination
THENA_RS00735	COG0497	DNA recombination
THENA_RS00750	COG0347	Belongs to the P(II) protein family
THENA_RS00755	COG0019	diaminopimelate decarboxylase activity
THENA_RS00765	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
THENA_RS00775	COG1418	mRNA catabolic process
THENA_RS00780	COG1692	metallophosphoesterase
THENA_RS00790	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
THENA_RS00795	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
THENA_RS00810	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
THENA_RS00820	COG1674	ftsk spoiiie
THENA_RS00830	COG0529	Catalyzes the synthesis of activated sulfate
THENA_RS00830	COG2046	Belongs to the sulfate adenylyltransferase family
THENA_RS00850	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
THENA_RS00880	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
THENA_RS00890	COG1157	protein secretion by the type III secretion system
THENA_RS00895	COG1419	protein localization to endoplasmic reticulum
THENA_RS00910	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
THENA_RS00925	COG1215	transferase activity, transferring glycosyl groups
THENA_RS00930	COG2205	protein histidine kinase activity
THENA_RS00940	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
THENA_RS00945	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
THENA_RS00955	COG0281	malic enzyme
THENA_RS00975	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
THENA_RS00980	COG0493	'glutamate synthase
THENA_RS00995	COG0481	GTPase activity
THENA_RS01000	COG0635	Involved in the biosynthesis of porphyrin-containing compound
THENA_RS01015	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
THENA_RS01015	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
THENA_RS01020	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
THENA_RS01025	COG0322	excinuclease ABC activity
THENA_RS01030	COG0739	heme binding
THENA_RS01035	COG0612	Peptidase, M16
THENA_RS01040	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
THENA_RS01045	COG2359	stage V sporulation protein S
THENA_RS01055	COG1187	pseudouridine synthase activity
THENA_RS01060	COG0425	Belongs to the sulfur carrier protein TusA family
THENA_RS01065	COG1104	cysteine desulfurase activity
THENA_RS01075	COG0728	peptidoglycan biosynthetic process
THENA_RS01085	COG2359	stage V sporulation protein S
THENA_RS01105	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
THENA_RS01110	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
THENA_RS01110	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
THENA_RS01115	COG0084	hydrolase, TatD family'
THENA_RS01120	COG1355	regulation of microtubule-based process
THENA_RS01125	COG1324	tolerance protein
THENA_RS01130	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
THENA_RS01145	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
THENA_RS01150	COG0083	homoserine kinase activity
THENA_RS01155	COG0527	aspartate kinase activity
THENA_RS01175	COG1105	Belongs to the carbohydrate kinase PfkB family
THENA_RS01185	COG0805	protein transport
THENA_RS01195	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
THENA_RS01200	COG2252	PERMEase
THENA_RS01205	COG1217	gtp-binding protein TYPA
THENA_RS01210	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
THENA_RS01220	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
THENA_RS01220	COG2199	diguanylate cyclase activity
THENA_RS01230	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
THENA_RS01240	COG0583	DNA-binding transcription factor activity
THENA_RS01255	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
THENA_RS01265	COG0438	transferase activity, transferring glycosyl groups
THENA_RS01275	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
THENA_RS01280	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
THENA_RS01285	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
THENA_RS01300	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
THENA_RS01305	COG0438	transferase activity, transferring glycosyl groups
THENA_RS01310	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
THENA_RS01315	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
THENA_RS01320	COG1793	dna ligase
THENA_RS01325	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
THENA_RS01335	COG0012	GTP binding
THENA_RS01350	COG0360	Binds together with S18 to 16S ribosomal RNA
THENA_RS01355	COG0629	single-stranded DNA binding
THENA_RS01360	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
THENA_RS01375	COG0358	DNA primase activity
THENA_RS01380	COG0802	atpase or kinase
THENA_RS01395	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
THENA_RS01400	COG0193	aminoacyl-tRNA hydrolase activity
THENA_RS01410	COG0165	Argininosuccinate lyase
THENA_RS01410	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
THENA_RS01415	COG0736	holo-[acyl-carrier-protein] synthase activity
THENA_RS01425	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
THENA_RS01430	COG0291	Belongs to the bacterial ribosomal protein bL35 family
THENA_RS01435	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
THENA_RS01440	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
THENA_RS01450	COG1966	Carbon starvation protein
THENA_RS01455	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
THENA_RS01460	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
THENA_RS01470	COG0719	Fe-S assembly protein
THENA_RS01475	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
THENA_RS01485	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
THENA_RS01490	COG0543	2 iron, 2 sulfur cluster binding
THENA_RS01515	COG1388	LysM domain
THENA_RS01515	COG0791	NLP P60 protein
THENA_RS01530	COG0402	S-adenosylhomocysteine deaminase activity
THENA_RS01535	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
THENA_RS01545	COG1459	type II secretion system
THENA_RS01555	COG0432	Pfam Uncharacterised protein family UPF0047
THENA_RS01575	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
THENA_RS01580	COG0628	permease
THENA_RS01585	COG1012	belongs to the aldehyde dehydrogenase family
THENA_RS01590	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
THENA_RS01590	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
THENA_RS01605	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
THENA_RS01640	COG3706	GGDEF domain
THENA_RS01665	COG0248	Ppx GppA phosphatase
THENA_RS01665	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
THENA_RS01700	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
THENA_RS01705	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
THENA_RS01710	COG0542	response to heat
THENA_RS01715	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
THENA_RS01730	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
THENA_RS01775	COG1929	Belongs to the glycerate kinase type-1 family
THENA_RS01780	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
THENA_RS01795	COG0475	glutathione-regulated potassium exporter activity
THENA_RS01805	COG0009	L-threonylcarbamoyladenylate synthase
THENA_RS01810	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
THENA_RS01825	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
THENA_RS01840	COG0517	IMP dehydrogenase activity
THENA_RS01870	COG2814	Major facilitator Superfamily
THENA_RS01890	COG0662	Cupin 2, conserved barrel domain protein
THENA_RS01895	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
THENA_RS02005	COG0463	Glycosyl transferase, family 2
THENA_RS02015	COG0438	transferase activity, transferring glycosyl groups
THENA_RS02015	COG1216	Glycosyl transferase, family 2
THENA_RS02040	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
THENA_RS02045	COG0463	Glycosyl transferase, family 2
THENA_RS02065	COG2801	Transposase and inactivated derivatives
THENA_RS02080	COG1598	PFAM Uncharacterised protein family UPF0150
THENA_RS02130	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
THENA_RS02135	COG1850	ribulose-bisphosphate carboxylase activity
THENA_RS02145	COG3959	Transketolase, thiamine diphosphate binding domain
THENA_RS02150	COG3958	Transketolase
THENA_RS02160	COG0126	phosphoglycerate kinase activity
THENA_RS02165	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
THENA_RS02170	COG0698	ribose 5-phosphate isomerase
THENA_RS02175	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
THENA_RS02185	COG1937	Protein conserved in bacteria
THENA_RS02205	COG2217	Heavy metal translocating P-type atpase
THENA_RS02220	COG2814	Major facilitator Superfamily
THENA_RS02230	COG0417	DNA replication proofreading
THENA_RS02235	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
THENA_RS02250	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
THENA_RS02255	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
THENA_RS02260	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
THENA_RS02275	COG1592	Rubrerythrin
THENA_RS02305	COG1979	alcohol dehydrogenase
THENA_RS02325	COG0247	lactate metabolic process
THENA_RS02325	COG2181	nitrate reductase activity
THENA_RS02340	COG2878	Part of a membrane complex involved in electron transport
THENA_RS02345	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
THENA_RS02345	COG0493	'glutamate synthase
THENA_RS02355	COG0425	Belongs to the sulfur carrier protein TusA family
THENA_RS02370	COG0739	heme binding
THENA_RS02375	COG0492	ferredoxin-NADP+ reductase activity
THENA_RS02405	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
THENA_RS02410	COG1570	exodeoxyribonuclease VII activity
THENA_RS02420	COG1227	inorganic diphosphatase activity
THENA_RS02425	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
THENA_RS02430	COG3956	TIGRFAM MazG family protein
THENA_RS02435	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
THENA_RS02445	COG1098	S1 RNA binding domain
THENA_RS02450	COG0137	argininosuccinate synthase activity
THENA_RS02455	COG0165	Argininosuccinate lyase
THENA_RS02465	COG0601	transmembrane transport
THENA_RS02480	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
THENA_RS02485	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
THENA_RS02490	COG1144	Oxidoreductase
THENA_RS02495	COG0674	pyruvate-flavodoxin oxidoreductase activity
THENA_RS02500	COG1013	pyruvate-flavodoxin oxidoreductase activity
THENA_RS02505	COG0352	thiamine-phosphate diphosphorylase activity
THENA_RS02515	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
THENA_RS02525	COG0049	tRNA binding
THENA_RS02530	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
THENA_RS02540	COG0051	transcription antitermination factor activity, RNA binding
THENA_RS02545	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
THENA_RS02550	COG0088	Forms part of the polypeptide exit tunnel
THENA_RS02555	COG0089	rRNA binding
THENA_RS02560	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
THENA_RS02565	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
THENA_RS02575	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
THENA_RS02580	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
THENA_RS02585	COG0255	Belongs to the universal ribosomal protein uL29 family
THENA_RS02590	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
THENA_RS02595	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
THENA_RS02600	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
THENA_RS02610	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
THENA_RS02615	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
THENA_RS02620	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
THENA_RS02630	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
THENA_RS02635	COG0200	Binds to the 23S rRNA
THENA_RS02650	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
THENA_RS02655	COG0257	Belongs to the bacterial ribosomal protein bL36 family
THENA_RS02660	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
THENA_RS02665	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
THENA_RS02670	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
THENA_RS02675	COG0202	RNA polymerase activity
THENA_RS02680	COG0203	ribosomal protein L17
THENA_RS02690	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
THENA_RS02695	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
THENA_RS02700	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
THENA_RS02705	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
THENA_RS02710	COG0588	phosphoglycerate mutase activity
THENA_RS02715	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
THENA_RS02720	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
THENA_RS02740	COG1902	pentaerythritol trinitrate reductase activity
THENA_RS02770	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
THENA_RS02770	COG1918	ferrous iron import across plasma membrane
THENA_RS02775	COG0497	DNA recombination
THENA_RS02785	COG0267	Belongs to the bacterial ribosomal protein bL33 family
THENA_RS02795	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
THENA_RS02800	COG0250	Participates in transcription elongation, termination and antitermination
THENA_RS02805	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
THENA_RS02810	COG0081	regulation of translation
THENA_RS02815	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
THENA_RS02820	COG0222	ribosome binding
THENA_RS02825	COG0667	Aldo Keto reductase
THENA_RS02835	COG3290	protein histidine kinase activity
THENA_RS02835	COG0840	transmembrane signaling receptor activity
THENA_RS02845	COG0631	protein serine/threonine phosphatase activity
THENA_RS02855	COG0028	Belongs to the TPP enzyme family
THENA_RS02860	COG0440	acetolactate synthase activity
THENA_RS02865	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
THENA_RS02870	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
THENA_RS02910	COG0438	transferase activity, transferring glycosyl groups
THENA_RS02920	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
THENA_RS02925	COG0613	PHP domain protein
THENA_RS02945	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
THENA_RS02950	COG1185	polyribonucleotide nucleotidyltransferase activity
THENA_RS02955	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
THENA_RS02970	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
THENA_RS02975	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
THENA_RS02985	COG0356	it plays a direct role in the translocation of protons across the membrane
THENA_RS03000	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
THENA_RS03005	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
THENA_RS03015	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
THENA_RS03020	COG0355	proton-transporting ATP synthase activity, rotational mechanism
THENA_RS03025	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
THENA_RS03035	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
THENA_RS03040	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
THENA_RS03045	COG0779	Required for maturation of 30S ribosomal subunits
THENA_RS03050	COG0195	Participates in both transcription termination and antitermination
THENA_RS03060	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
THENA_RS03070	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
THENA_RS03080	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
THENA_RS03085	COG0196	riboflavin kinase activity
THENA_RS03100	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
THENA_RS03110	COG0131	Imidazoleglycerol-phosphate dehydratase
THENA_RS03115	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
THENA_RS03120	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
THENA_RS03125	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
THENA_RS03130	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
THENA_RS03135	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
THENA_RS03140	COG0138	bifunctional purine biosynthesis protein purh
THENA_RS03145	COG0151	Belongs to the GarS family
THENA_RS03150	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
THENA_RS03160	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
THENA_RS03165	COG0154	amidase activity
THENA_RS03180	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
THENA_RS03190	COG1797	cobyrinic acid a,c-diamide synthase activity
THENA_RS03210	COG3260	NADH ubiquinone oxidoreductase 20
THENA_RS03220	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
THENA_RS03230	COG3261	NADH dehydrogenase
THENA_RS03230	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
THENA_RS03235	COG0649	NAD binding
THENA_RS03240	COG2814	Major facilitator Superfamily
THENA_RS03250	COG0385	Bile acid
THENA_RS03255	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
THENA_RS03260	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
THENA_RS03265	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
THENA_RS03275	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
THENA_RS03280	COG0071	Belongs to the small heat shock protein (HSP20) family
THENA_RS03300	COG0497	DNA recombination
THENA_RS03310	COG2001	Belongs to the MraZ family
THENA_RS03315	COG0275	rRNA processing
THENA_RS03325	COG0768	penicillin binding
THENA_RS03330	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
THENA_RS03335	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
THENA_RS03340	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
THENA_RS03345	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
THENA_RS03350	COG0772	Belongs to the SEDS family
THENA_RS03355	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
THENA_RS03360	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
THENA_RS03365	COG0812	UDP-N-acetylmuramate dehydrogenase activity
THENA_RS03370	COG1181	Belongs to the D-alanine--D-alanine ligase family
THENA_RS03385	COG3856	small basic protein
THENA_RS03390	COG0849	cell division
THENA_RS03395	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
THENA_RS03405	COG1316	TRANSCRIPTIONal
THENA_RS03410	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
THENA_RS03420	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
THENA_RS03430	COG1077	Cell shape determining protein MreB Mrl
THENA_RS03445	COG0768	penicillin binding
THENA_RS03450	COG0850	regulation of cytokinetic process
THENA_RS03455	COG2894	cell division
THENA_RS03460	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
THENA_RS03475	COG1199	ATP-dependent helicase activity
THENA_RS03480	COG3885	ferrous iron binding
THENA_RS03480	COG2078	PFAM AMMECR1 domain protein
THENA_RS03490	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
THENA_RS03495	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
THENA_RS03495	COG0072	phenylalanine-tRNA ligase activity
THENA_RS03505	COG1796	DNA polymerase
THENA_RS03505	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
THENA_RS03520	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
THENA_RS03525	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
THENA_RS03530	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
THENA_RS03535	COG0494	nUDIX hydrolase
THENA_RS03540	COG4974	Belongs to the 'phage' integrase family
THENA_RS03545	COG1012	belongs to the aldehyde dehydrogenase family
THENA_RS03550	COG0506	proline dehydrogenase activity
THENA_RS03580	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
THENA_RS03610	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
THENA_RS03620	COG4589	Belongs to the CDS family
THENA_RS03625	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
THENA_RS03630	COG0750	zinc metalloprotease
THENA_RS03640	COG0442	prolyl-tRNA aminoacylation
THENA_RS03645	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
THENA_RS03650	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
THENA_RS03655	COG0375	protein maturation
THENA_RS03670	COG0018	arginyl-trna synthetase
THENA_RS03675	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
THENA_RS03680	COG0540	Belongs to the ATCase OTCase family
THENA_RS03685	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
THENA_RS03690	COG0505	Belongs to the CarA family
THENA_RS03695	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
THENA_RS03705	COG0037	tRNA processing
THENA_RS03710	COG1811	Na channel or pump
THENA_RS03715	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
THENA_RS03720	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
THENA_RS03730	COG1045	serine acetyltransferase
THENA_RS03740	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
THENA_RS03750	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
THENA_RS03775	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
THENA_RS03780	COG0287	Prephenate dehydrogenase
THENA_RS03785	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
THENA_RS03790	COG0617	tRNA 3'-terminal CCA addition
THENA_RS03800	COG0446	pyridine nucleotide-disulphide oxidoreductase
THENA_RS03820	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
THENA_RS03825	COG3854	ATPases associated with a variety of cellular activities
THENA_RS03830	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
THENA_RS03835	COG0470	DNA polymerase III
THENA_RS03840	COG1774	PSP1 C-terminal conserved region
THENA_RS03850	COG0166	Belongs to the GPI family
THENA_RS03855	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
THENA_RS03865	COG2801	Transposase and inactivated derivatives
THENA_RS03880	COG1278	Cold shock
THENA_RS03885	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
THENA_RS03890	COG0653	protein targeting
THENA_RS03895	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
THENA_RS03905	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
THENA_RS03910	COG3959	Transketolase, thiamine diphosphate binding domain
THENA_RS03915	COG3958	Transketolase
THENA_RS03920	COG2884	Cell division ATP-binding protein ftsE
THENA_RS03925	COG2177	Part of the ABC transporter FtsEX involved in
THENA_RS03930	COG1573	uracil-dna glycosylase
THENA_RS03945	COG0564	pseudouridine synthase activity
THENA_RS03955	COG1635	Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur
THENA_RS03960	COG0443	Heat shock 70 kDa protein
THENA_RS03965	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
THENA_RS03970	COG0484	heat shock protein binding
THENA_RS03975	COG0789	Transcriptional regulator
THENA_RS03980	COG0542	response to heat
THENA_RS03990	COG0194	GDP metabolic process
THENA_RS03995	COG1758	RNA polymerase activity
THENA_RS04000	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
THENA_RS04005	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
THENA_RS04025	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
THENA_RS04025	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
THENA_RS04075	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
THENA_RS04080	COG0556	nucleotide-excision repair
THENA_RS04085	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
THENA_RS04090	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
THENA_RS04100	COG1872	DUF167
THENA_RS04105	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
THENA_RS04115	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
THENA_RS04120	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
THENA_RS04125	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
THENA_RS04130	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
THENA_RS04145	COG1278	Cold shock
THENA_RS04185	COG1518	maintenance of DNA repeat elements
THENA_RS04190	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
THENA_RS04240	COG2814	Major facilitator Superfamily
THENA_RS04245	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
THENA_RS04255	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
THENA_RS04260	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
THENA_RS04265	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
THENA_RS04295	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
THENA_RS04300	COG0463	Glycosyl transferase, family 2
THENA_RS04320	COG1968	undecaprenyl-diphosphatase activity
THENA_RS04335	COG0859	PFAM glycosyl transferase family 9
THENA_RS04350	COG2244	polysaccharide biosynthetic process
THENA_RS04355	COG0463	Glycosyl transferase, family 2
THENA_RS04365	COG1136	(ABC) transporter
THENA_RS04365	COG0577	efflux transmembrane transporter activity
THENA_RS04370	COG0277	FAD linked oxidase domain protein
THENA_RS04385	COG0667	Aldo Keto reductase
THENA_RS04425	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
THENA_RS04450	COG0667	Aldo Keto reductase
THENA_RS04455	COG0789	Transcriptional regulator
THENA_RS04460	COG1012	belongs to the aldehyde dehydrogenase family
THENA_RS04470	COG1012	belongs to the aldehyde dehydrogenase family
THENA_RS04485	COG0495	leucyl-tRNA aminoacylation
THENA_RS04495	COG0658	competence protein
THENA_RS04505	COG0268	Binds directly to 16S ribosomal RNA
THENA_RS04510	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
THENA_RS04515	COG0756	dUTP diphosphatase activity
THENA_RS04520	COG0217	transcriptional regulatory protein
THENA_RS04525	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
THENA_RS04530	COG0632	four-way junction helicase activity
THENA_RS04535	COG2255	four-way junction helicase activity
THENA_RS04540	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
THENA_RS04540	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
THENA_RS04550	COG1013	pyruvate-flavodoxin oxidoreductase activity
THENA_RS04555	COG0535	radical SAM domain protein
THENA_RS04575	COG0067	glutamate synthase
THENA_RS04590	COG0305	Participates in initiation and elongation during chromosome replication
THENA_RS04595	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
THENA_RS04600	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
THENA_RS04630	COG1473	amidohydrolase
THENA_RS04640	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
THENA_RS04660	COG0518	GMP synthase (glutamine-hydrolyzing) activity
THENA_RS04660	COG0519	Catalyzes the synthesis of GMP from XMP
THENA_RS04670	COG2814	Major facilitator Superfamily
THENA_RS04675	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
THENA_RS04685	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
THENA_RS04690	COG1396	sequence-specific DNA binding
THENA_RS04695	COG1331	Highly conserved protein containing a thioredoxin domain
THENA_RS04710	COG2814	Major facilitator Superfamily
THENA_RS04725	COG0655	NAD(P)H dehydrogenase (quinone) activity
THENA_RS04775	COG0436	Aminotransferase
THENA_RS04780	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
THENA_RS04785	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
THENA_RS04820	COG2059	Chromate
THENA_RS04825	COG2271	Major facilitator Superfamily
THENA_RS04835	COG1139	Iron-sulfur cluster binding protein
THENA_RS04840	COG2414	aldehyde ferredoxin oxidoreductase
THENA_RS04855	COG0483	inositol monophosphate 1-phosphatase activity
THENA_RS04880	COG0284	orotidine-5'-phosphate decarboxylase activity
THENA_RS04895	COG0521	Mo-molybdopterin cofactor biosynthetic process
THENA_RS04900	COG0315	cyclic pyranopterin monophosphate synthase activity
THENA_RS04905	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
THENA_RS04910	COG1910	domain protein
THENA_RS04915	COG0303	'Molybdopterin
THENA_RS04920	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
THENA_RS04935	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
THENA_RS04940	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
THENA_RS04950	COG0181	hydroxymethylbilane synthase activity
THENA_RS04960	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
THENA_RS04965	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
THENA_RS04965	COG1648	precorrin-2 dehydrogenase activity
THENA_RS04975	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
THENA_RS04980	COG0720	synthase
THENA_RS04985	COG0445	tRNA wobble uridine modification
THENA_RS04990	COG0758	DNA mediated transformation
THENA_RS04995	COG0606	chelatase, subunit chli
THENA_RS05000	COG0792	nuclease activity
THENA_RS05005	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
THENA_RS05010	COG0681	Belongs to the peptidase S26 family
THENA_RS05015	COG0335	large ribosomal subunit rRNA binding
THENA_RS05020	COG0336	Belongs to the RNA methyltransferase TrmD family
THENA_RS05030	COG0228	four-way junction DNA binding
THENA_RS05035	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
THENA_RS05040	COG0552	protein localization to endoplasmic reticulum
THENA_RS05055	COG1196	nuclear chromosome segregation
THENA_RS05060	COG0142	geranyltranstransferase activity
THENA_RS05065	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
THENA_RS05070	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
THENA_RS05075	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
THENA_RS05080	COG0497	DNA recombination
THENA_RS05090	COG0460	homoserine dehydrogenase
THENA_RS05095	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
THENA_RS05095	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
THENA_RS05100	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
THENA_RS05100	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
THENA_RS05105	COG0820	rRNA (adenine-C2-)-methyltransferase activity
THENA_RS05115	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
THENA_RS05120	COG0242	peptide deformylase activity
THENA_RS05130	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
THENA_RS05145	COG2814	Major facilitator Superfamily
THENA_RS05150	COG2759	Belongs to the formate--tetrahydrofolate ligase family
THENA_RS05170	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
THENA_RS05190	COG1074	ATP-dependent DNA helicase activity
THENA_RS05210	COG1297	OPT oligopeptide transporter protein
THENA_RS05215	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
THENA_RS05220	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
THENA_RS05230	COG0179	Fumarylacetoacetate (FAA) hydrolase
THENA_RS05240	COG0546	phosphoglycolate phosphatase activity
THENA_RS05245	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
THENA_RS05255	COG0444	Belongs to the ABC transporter superfamily
THENA_RS05305	COG3383	formate dehydrogenase (NAD+) activity
THENA_RS05350	COG0310	cobalt ion transport
THENA_RS05360	COG1122	ATPase activity
THENA_RS05390	COG5434	Belongs to the glycosyl hydrolase 28 family
THENA_RS05390	COG4632	Exopolysaccharide biosynthesis protein
THENA_RS05425	COG2084	Dehydrogenase
THENA_RS05440	COG0651	ATP synthesis coupled electron transport
THENA_RS05445	COG0649	NAD binding
THENA_RS05455	COG0651	ATP synthesis coupled electron transport
THENA_RS05465	COG5001	Diguanylate cyclase
THENA_RS05475	COG1522	sequence-specific DNA binding
THENA_RS05490	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
THENA_RS05495	COG1139	Iron-sulfur cluster binding protein
THENA_RS05515	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
THENA_RS05535	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
THENA_RS05540	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
THENA_RS05545	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
THENA_RS05550	COG0298	carbon dioxide binding
THENA_RS05555	COG0409	Hydrogenase expression formation protein
THENA_RS05565	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
THENA_RS05580	COG1013	pyruvate-flavodoxin oxidoreductase activity
THENA_RS05585	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
THENA_RS05585	COG0674	pyruvate-flavodoxin oxidoreductase activity
THENA_RS05595	COG0066	3-isopropylmalate dehydratase activity
THENA_RS05600	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
THENA_RS05625	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
THENA_RS05630	COG4943	cyclic-guanylate-specific phosphodiesterase activity
THENA_RS05635	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
THENA_RS05700	COG1132	(ABC) transporter
THENA_RS05710	COG0822	iron-sulfur transferase activity
THENA_RS05720	COG0446	pyridine nucleotide-disulphide oxidoreductase
THENA_RS05725	COG1921	L-seryl-tRNASec selenium transferase activity
THENA_RS05740	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
THENA_RS05770	COG5001	Diguanylate cyclase
THENA_RS05770	COG3300	MHYT domain
THENA_RS05775	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
THENA_RS05800	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
THENA_RS05820	COG1136	(ABC) transporter
THENA_RS05825	COG1136	(ABC) transporter
THENA_RS05825	COG0577	efflux transmembrane transporter activity
THENA_RS05830	COG0577	efflux transmembrane transporter activity
THENA_RS05830	COG1136	(ABC) transporter
THENA_RS05840	COG0437	4 iron, 4 sulfur cluster binding
THENA_RS05860	COG0437	4 iron, 4 sulfur cluster binding
THENA_RS05875	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
THENA_RS05880	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
THENA_RS05885	COG0095	Lipoate-protein ligase
THENA_RS05890	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
THENA_RS05895	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
THENA_RS05900	COG0509	glycine decarboxylation via glycine cleavage system
THENA_RS05910	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
THENA_RS05915	COG1490	D-aminoacyl-tRNA deacylase activity
THENA_RS05920	COG0167	dihydroorotate dehydrogenase activity
THENA_RS05935	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
THENA_RS05940	COG4399	Belongs to the UPF0754 family
THENA_RS05960	COG0497	DNA recombination
THENA_RS05970	COG0697	spore germination
THENA_RS06025	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
THENA_RS06030	COG1362	aminopeptidase activity
THENA_RS06035	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
THENA_RS06035	COG0731	radical SAM domain protein
THENA_RS06050	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
THENA_RS06055	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
THENA_RS06080	COG2193	ferroxidase activity
THENA_RS06090	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
THENA_RS06095	COG0066	3-isopropylmalate dehydratase activity
THENA_RS06100	COG0473	3-isopropylmalate dehydrogenase activity
THENA_RS06105	COG1210	Utp--glucose-1-phosphate uridylyltransferase
THENA_RS06125	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
THENA_RS06130	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
THENA_RS06135	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
THENA_RS06145	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
THENA_RS06155	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
THENA_RS06165	COG0740	serine-type endopeptidase activity
THENA_RS06170	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
THENA_RS06185	COG5001	Diguanylate cyclase
THENA_RS06185	COG3300	MHYT domain
THENA_RS06200	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
THENA_RS06205	COG0708	Exodeoxyribonuclease III
THENA_RS06210	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
THENA_RS06215	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
THENA_RS06220	COG1522	sequence-specific DNA binding
THENA_RS06225	COG0535	radical SAM domain protein
THENA_RS06230	COG0113	porphobilinogen synthase activity
THENA_RS06235	COG0535	radical SAM domain protein
THENA_RS06240	COG0489	protein tyrosine kinase activity
THENA_RS06245	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
THENA_RS06265	COG0037	tRNA processing
THENA_RS06285	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
THENA_RS06285	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
THENA_RS06290	COG4956	integral membrane protein (PIN domain superfamily)
THENA_RS06330	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
THENA_RS06335	COG0220	tRNA (guanine-N7-)-methyltransferase activity
THENA_RS06335	COG2890	protein-(glutamine-N5) methyltransferase activity
THENA_RS06340	COG1802	Transcriptional regulator
THENA_RS06350	COG0805	protein transport
THENA_RS06360	COG1058	Belongs to the CinA family
THENA_RS06360	COG1546	Belongs to the CinA family
THENA_RS06365	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
THENA_RS06375	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
THENA_RS06385	COG0180	Tryptophanyl-tRNA synthetase
THENA_RS06395	COG1994	Peptidase M50
THENA_RS06400	COG0617	tRNA 3'-terminal CCA addition
THENA_RS06400	COG3620	sequence-specific DNA binding
THENA_RS06400	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
THENA_RS06405	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
THENA_RS06420	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
THENA_RS06430	COG2848	UPF0210 protein
THENA_RS06440	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
THENA_RS06445	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
THENA_RS06470	COG1053	succinate dehydrogenase
THENA_RS06485	COG0477	Major facilitator Superfamily
THENA_RS06485	COG2814	Major facilitator Superfamily
THENA_RS06490	COG4178	(ABC) transporter
THENA_RS06505	COG3681	Belongs to the UPF0597 family
THENA_RS06515	COG0251	oxidation-reduction process
THENA_RS06520	COG1760	l-serine dehydratase
THENA_RS06525	COG1760	l-serine dehydratase
THENA_RS06530	COG1113	amino acid transport
THENA_RS06535	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
THENA_RS06540	COG0148	phosphopyruvate hydratase activity
THENA_RS06545	COG0725	ABC transporter, periplasmic molybdate-binding protein
THENA_RS06550	COG4149	molybdate abc transporter
THENA_RS06555	COG3842	ATPase activity
THENA_RS06560	COG1285	pathogenesis
THENA_RS06570	COG0735	belongs to the Fur family
THENA_RS06575	COG1942	4-Oxalocrotonate Tautomerase
THENA_RS06585	COG0237	dephospho-CoA kinase activity
THENA_RS06620	COG0519	Catalyzes the synthesis of GMP from XMP
THENA_RS06620	COG0518	GMP synthase (glutamine-hydrolyzing) activity
THENA_RS06625	COG0516	GMP reductase activity
THENA_RS06630	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
THENA_RS06635	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
THENA_RS06635	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
THENA_RS06640	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
THENA_RS06640	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
THENA_RS06645	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
THENA_RS06650	COG0438	transferase activity, transferring glycosyl groups
THENA_RS06655	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
THENA_RS06660	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
THENA_RS06665	COG0085	RNA polymerase activity
THENA_RS06690	COG0668	transmembrane transport
THENA_RS06695	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
THENA_RS06710	COG1454	alcohol dehydrogenase
THENA_RS06730	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
THENA_RS06745	COG1420	regulation of RNA biosynthetic process
THENA_RS06750	COG0129	dihydroxy-acid dehydratase activity
THENA_RS06755	COG0799	negative regulation of ribosome biogenesis
THENA_RS06765	COG0227	Belongs to the bacterial ribosomal protein bL28 family
THENA_RS06775	COG2920	part of a sulfur-relay system
THENA_RS06800	COG3259	Nickel-dependent hydrogenase
THENA_RS06835	COG0525	valine-tRNA ligase activity
THENA_RS06840	COG0285	dihydrofolate synthase activity
THENA_RS06845	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
THENA_RS06845	COG0730	response to heat
THENA_RS06860	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
THENA_RS06870	COG0140	phosphoribosyl-ATP diphosphatase activity
THENA_RS06870	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
THENA_RS06875	COG0233	cytoplasmic translational termination
THENA_RS06880	COG0528	UMP kinase activity
THENA_RS06885	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
THENA_RS06890	COG0052	Belongs to the universal ribosomal protein uS2 family
THENA_RS06910	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
THENA_RS06925	COG0628	permease
THENA_RS06930	COG1131	(ABC) transporter
THENA_RS06940	COG0825	malonyl-CoA metabolic process
THENA_RS06945	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
THENA_RS06955	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
THENA_RS06960	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
THENA_RS06965	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
THENA_RS06975	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
THENA_RS06980	COG0211	Belongs to the bacterial ribosomal protein bL27 family
THENA_RS07005	COG2221	Nitrite and sulphite reductase 4Fe-4S
THENA_RS07010	COG2221	Nitrite and sulphite reductase 4Fe-4S
THENA_RS07015	COG2920	part of a sulfur-relay system
THENA_RS07020	COG0247	lactate metabolic process
THENA_RS07030	COG0037	tRNA processing
THENA_RS07035	COG0482	sulfurtransferase activity
THENA_RS07040	COG3118	belongs to the thioredoxin family
THENA_RS07045	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
THENA_RS07050	COG0210	DNA helicase
THENA_RS07060	COG0124	histidyl-tRNA synthetase
THENA_RS07065	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
THENA_RS07075	COG0497	DNA recombination
THENA_RS07080	COG0596	Alpha beta hydrolase
THENA_RS07090	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
THENA_RS07095	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
THENA_RS07100	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
THENA_RS07110	COG2084	Dehydrogenase
THENA_RS07115	COG0765	amino acid transport
THENA_RS07120	COG0765	amino acid transport
THENA_RS07125	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
THENA_RS07130	COG1126	abc transporter atp-binding protein
THENA_RS07135	COG0640	Transcriptional regulator
THENA_RS07140	COG1132	(ABC) transporter
THENA_RS07145	COG1519	Transferase
THENA_RS07150	COG1663	tetraacyldisaccharide 4'-kinase activity
THENA_RS07155	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
THENA_RS07165	COG3409	Peptidoglycan-binding domain 1 protein
THENA_RS07165	COG0793	Belongs to the peptidase S41A family
THENA_RS07185	COG1940	carbohydrate kinase activity
THENA_RS07235	COG1720	tRNA m6t6A37 methyltransferase activity
THENA_RS07245	COG0848	biopolymer transport protein
THENA_RS07250	COG0811	peptide transport
THENA_RS07265	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
THENA_RS07295	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
THENA_RS07300	COG0857	belongs to the CobB CobQ family
THENA_RS07305	COG1042	CoA-binding domain protein
THENA_RS07305	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
THENA_RS07305	COG0045	succinate-CoA ligase (ADP-forming) activity
THENA_RS07310	COG0277	FAD linked oxidase domain protein
THENA_RS07320	COG0277	FAD linked oxidase domain protein
THENA_RS07330	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
THENA_RS07340	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
THENA_RS07350	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
THENA_RS07355	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
THENA_RS07360	COG0416	fatty acid biosynthetic process
THENA_RS07365	COG0333	Belongs to the bacterial ribosomal protein bL32 family
THENA_RS07380	COG0501	Belongs to the peptidase M48B family
THENA_RS07390	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
THENA_RS07395	COG0531	amino acid
THENA_RS07400	COG2271	Major facilitator Superfamily
THENA_RS07420	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
THENA_RS07425	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
THENA_RS07445	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
THENA_RS07455	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
THENA_RS07465	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
THENA_RS07495	COG0745	RESPONSE REGULATOR receiver
THENA_RS07510	COG0602	queuosine metabolic process
THENA_RS07515	COG0720	synthase
THENA_RS07530	COG0670	Belongs to the BI1 family
THENA_RS07555	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
THENA_RS07560	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
THENA_RS07575	COG0704	Plays a role in the regulation of phosphate uptake
THENA_RS07580	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
THENA_RS07585	COG0581	inorganic phosphate transmembrane transporter activity
THENA_RS07610	COG0232	Belongs to the dGTPase family. Type 2 subfamily
THENA_RS07615	COG0574	Belongs to the PEP-utilizing enzyme family
THENA_RS07615	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
THENA_RS07620	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
THENA_RS07625	COG0751	glycine-tRNA ligase activity
THENA_RS07630	COG0752	glycyl-tRNA synthetase alpha subunit
THENA_RS07635	COG1215	transferase activity, transferring glycosyl groups
THENA_RS07645	COG2814	Major facilitator Superfamily
THENA_RS07660	COG0504	CTP synthase activity
THENA_RS07665	COG4535	Mg2 and Co2 transporter CorC
THENA_RS07670	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
THENA_RS07675	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
THENA_RS07680	COG1480	7TM receptor with intracellular HD hydrolase
THENA_RS07685	COG0828	Belongs to the bacterial ribosomal protein bS21 family
THENA_RS07690	COG0537	adenosine 5'-monophosphoramidase activity
THENA_RS07700	COG3307	-O-antigen
THENA_RS07705	COG2200	EAL domain
THENA_RS07720	COG1027	Aspartate ammonia-lyase
THENA_RS07725	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
THENA_RS07730	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
THENA_RS07735	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
THENA_RS07760	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
THENA_RS07760	COG4624	Iron only hydrogenase large subunit, C-terminal domain
THENA_RS07765	COG2801	Transposase and inactivated derivatives
THENA_RS07775	COG3883	PFAM NLP P60 protein
THENA_RS07775	COG0791	NLP P60 protein
THENA_RS07780	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
THENA_RS07785	COG0586	Pfam SNARE associated Golgi protein
THENA_RS07795	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
THENA_RS07800	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
THENA_RS07805	COG0254	rRNA binding
THENA_RS07815	COG1294	oxidase, subunit
THENA_RS07820	COG1271	oxidase subunit
THENA_RS07825	COG4106	trans-aconitate 2-methyltransferase activity
THENA_RS07830	COG1342	Belongs to the UPF0251 family
THENA_RS07840	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
THENA_RS07845	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
THENA_RS07855	COG0513	Belongs to the DEAD box helicase family
THENA_RS07880	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
THENA_RS07880	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
THENA_RS07885	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
THENA_RS07890	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
THENA_RS07900	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
THENA_RS07915	COG2909	trisaccharide binding
THENA_RS07925	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
THENA_RS07930	COG1131	(ABC) transporter
THENA_RS07935	COG1131	(ABC) transporter
THENA_RS07945	COG0709	Synthesizes selenophosphate from selenide and ATP
THENA_RS07950	COG0842	Transport permease protein
THENA_RS07995	COG2197	response regulator
THENA_RS08015	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
THENA_RS08025	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
THENA_RS08050	COG1620	l-lactate permease
THENA_RS08110	COG0439	Biotin carboxylase
THENA_RS08115	COG0511	ligase activity, forming carbon-carbon bonds
THENA_RS08120	COG1151	hydroxylamine reductase activity
THENA_RS08125	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
THENA_RS08140	COG1966	Carbon starvation protein
THENA_RS08160	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
THENA_RS08175	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
THENA_RS08180	COG1233	COG1233 Phytoene dehydrogenase and related
THENA_RS08205	COG0563	adenylate kinase activity
THENA_RS08210	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
THENA_RS08215	COG1164	Oligoendopeptidase f
THENA_RS08220	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
THENA_RS08235	COG0489	protein tyrosine kinase activity
THENA_RS08245	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
THENA_RS08250	COG2059	Chromate
THENA_RS08265	COG0840	transmembrane signaling receptor activity
THENA_RS08275	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
THENA_RS08310	COG1660	Displays ATPase and GTPase activities
THENA_RS08315	COG0391	Required for morphogenesis under gluconeogenic growth conditions
THENA_RS08320	COG1481	regulation of sporulation
THENA_RS08325	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
THENA_RS08330	COG0126	phosphoglycerate kinase activity
THENA_RS08335	COG0149	triose-phosphate isomerase activity
THENA_RS08350	COG1304	FMN binding
THENA_RS08370	COG1584	GPR1 FUN34 yaaH family protein
THENA_RS08375	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
THENA_RS08385	COG1137	ATPase activity
THENA_RS08390	COG0571	ribonuclease III activity
THENA_RS08395	COG1984	allophanate hydrolase subunit 2
THENA_RS08400	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
THENA_RS08405	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
THENA_RS08410	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
THENA_RS08415	COG0077	Prephenate dehydratase
THENA_RS08415	COG1605	Chorismate mutase
THENA_RS08445	COG0489	protein tyrosine kinase activity
THENA_RS08455	COG2204	response regulator
THENA_RS08470	COG1515	deoxyribonuclease V activity
THENA_RS08475	COG1763	Mo-molybdopterin cofactor biosynthetic process
THENA_RS08485	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
THENA_RS08490	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
THENA_RS08495	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
THENA_RS08510	COG0438	transferase activity, transferring glycosyl groups
THENA_RS08515	COG3660	Nucleoside-diphosphate-sugar epimerase
THENA_RS08520	COG0750	zinc metalloprotease
THENA_RS08535	COG0730	response to heat
THENA_RS08555	COG2197	response regulator
THENA_RS08575	COG0546	phosphoglycolate phosphatase activity
THENA_RS08580	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
THENA_RS08585	COG0004	ammonium transporteR
THENA_RS08590	COG0004	ammonium transporteR
THENA_RS08600	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
THENA_RS08605	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
THENA_RS08615	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
THENA_RS08620	COG1766	The M ring may be actively involved in energy transduction
THENA_RS08630	COG1558	bacterial-type flagellum-dependent cell motility
THENA_RS08635	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
THENA_RS08645	COG4786	Flagellar basal body rod
THENA_RS08645	COG1256	bacterial-type flagellum assembly
THENA_RS08670	COG1706	bacterial-type flagellum-dependent cell motility
THENA_RS08675	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
THENA_RS08685	COG4786	Flagellar basal body rod
THENA_RS08715	COG5002	protein histidine kinase activity
THENA_RS08715	COG3850	Histidine kinase
THENA_RS08720	COG0745	RESPONSE REGULATOR receiver
THENA_RS08725	COG3290	protein histidine kinase activity
THENA_RS08725	COG0840	transmembrane signaling receptor activity
THENA_RS08735	COG2855	membrane
THENA_RS08735	COG2855	membrane
THENA_RS08740	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
THENA_RS08745	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
THENA_RS08755	COG0693	protein deglycase activity
THENA_RS08765	COG2239	Acts as a magnesium transporter
THENA_RS08770	COG1914	H( )-stimulated, divalent metal cation uptake system
THENA_RS08775	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
THENA_RS08790	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
THENA_RS08820	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
THENA_RS08845	COG1337	RAMP superfamily
THENA_RS08855	COG1353	crispr-associated protein
THENA_RS08905	COG1007	ATP synthesis coupled electron transport
THENA_RS08915	COG0651	ATP synthesis coupled electron transport
THENA_RS08925	COG0651	ATP synthesis coupled electron transport
THENA_RS08930	COG0713	ATP synthesis coupled electron transport
THENA_RS08935	COG0839	Belongs to the complex I subunit 6 family
THENA_RS08940	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
THENA_RS08945	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
THENA_RS08950	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
THENA_RS08955	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
THENA_RS08960	COG0649	NAD binding
THENA_RS08965	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
THENA_RS08970	COG0437	4 iron, 4 sulfur cluster binding
THENA_RS08980	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
THENA_RS09000	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
THENA_RS09020	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
THENA_RS09025	COG0501	Belongs to the peptidase M48B family
THENA_RS09035	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
THENA_RS09075	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
THENA_RS09080	COG0616	signal peptide processing
THENA_RS09100	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
THENA_RS09105	COG2814	Major facilitator Superfamily
THENA_RS09110	COG1566	PFAM secretion protein HlyD family protein
THENA_RS09115	COG0589	response to stress
THENA_RS09130	COG0330	HflC and HflK could
THENA_RS09170	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
THENA_RS09195	COG1546	Belongs to the CinA family
THENA_RS09195	COG1058	Belongs to the CinA family
THENA_RS09205	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
THENA_RS09215	COG1254	Belongs to the acylphosphatase family
THENA_RS09220	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
THENA_RS09220	COG1776	CheC inhibitor of MCP methylation
THENA_RS09225	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
THENA_RS09235	COG1582	Flagellar protein (FlbD)
THENA_RS09240	COG4786	Flagellar basal body rod
THENA_RS09255	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
THENA_RS09295	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
THENA_RS09305	COG2226	methyltransferase
THENA_RS09330	COG0105	UTP biosynthetic process
THENA_RS09335	COG1475	DNA binding
THENA_RS09340	COG1192	Involved in chromosome partitioning
THENA_RS09360	COG0512	Glutamine amidotransferase of anthranilate synthase
THENA_RS09360	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
THENA_RS09365	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
THENA_RS09375	COG0135	phosphoribosylanthranilate isomerase activity
THENA_RS09380	COG0133	tryptophan synthase activity
THENA_RS09385	COG0159	tryptophan synthase activity
THENA_RS09390	COG0516	GMP reductase activity
THENA_RS09390	COG0517	IMP dehydrogenase activity
THENA_RS09400	COG4149	molybdate abc transporter
THENA_RS09405	COG0725	ABC transporter, periplasmic molybdate-binding protein
THENA_RS09430	COG0706	membrane insertase activity
THENA_RS09445	COG0230	Belongs to the bacterial ribosomal protein bL34 family
THENA_RS09470	COG1285	pathogenesis
THENA_RS09485	COG0497	DNA recombination
THENA_RS09490	COG0726	polysaccharide deacetylase
THENA_RS09495	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
THENA_RS09495	COG0131	Imidazoleglycerol-phosphate dehydratase
THENA_RS09505	COG1216	Glycosyl transferase, family 2
THENA_RS09505	COG0463	Glycosyl transferase, family 2
THENA_RS09510	COG0739	heme binding
THENA_RS09515	COG0746	molybdenum cofactor guanylyltransferase activity
THENA_RS09520	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
THENA_RS09525	COG1309	transcriptional regulator
THENA_RS09530	COG2199	diguanylate cyclase activity
THENA_RS09530	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
THENA_RS09540	COG0590	tRNA wobble adenosine to inosine editing
THENA_RS09550	COG3858	chitin binding
THENA_RS09565	COG0572	uridine kinase
THENA_RS09575	COG0101	tRNA pseudouridine synthase activity
THENA_RS09590	COG0437	4 iron, 4 sulfur cluster binding
THENA_RS09600	COG0772	Belongs to the SEDS family
THENA_RS09605	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
THENA_RS09615	COG2205	protein histidine kinase activity
THENA_RS09630	COG1596	polysaccharide export
THENA_RS09630	COG1555	photosystem II stabilization
THENA_RS09640	COG2199	diguanylate cyclase activity
THENA_RS09680	COG2247	cell wall binding repeat
THENA_RS09680	COG0860	N-Acetylmuramoyl-L-alanine amidase
THENA_RS09690	COG3706	GGDEF domain
THENA_RS09695	COG0840	transmembrane signaling receptor activity
THENA_RS09705	COG3706	GGDEF domain
THENA_RS09710	COG0261	This protein binds to 23S rRNA in the presence of protein L20
THENA_RS09720	COG0497	DNA recombination
THENA_RS09740	COG1321	iron dependent repressor
THENA_RS09745	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
THENA_RS09760	COG0357	Ribosomal RNA small subunit methyltransferase G