locus-tag	class	description
N186_RS00010	COG1013	pyruvate-flavodoxin oxidoreductase activity
N186_RS00020	COG0493	'glutamate synthase
N186_RS00060	COG0417	DNA replication proofreading
N186_RS00090	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
N186_RS00090	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
N186_RS00095	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
N186_RS00105	COG1213	nucleotidyl transferase
N186_RS00105	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
N186_RS00120	COG0235	Class ii aldolase
N186_RS00175	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
N186_RS00195	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
N186_RS00210	COG0301	tRNA thio-modification
N186_RS00210	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
N186_RS00245	COG0494	nUDIX hydrolase
N186_RS00265	COG4221	oxidoreductase activity
N186_RS00310	COG1260	myo-inositol-1-phosphate synthase
N186_RS00315	COG4608	Belongs to the ABC transporter superfamily
N186_RS00330	COG0601	transmembrane transport
N186_RS00335	COG4166	transmembrane transport
N186_RS00425	COG4591	ABC-type transport system involved in lipoprotein release permease component
N186_RS00430	COG1136	(ABC) transporter
N186_RS00450	COG1063	alcohol dehydrogenase
N186_RS00455	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
N186_RS00460	COG1840	ABC-type Fe3 transport system, periplasmic component
N186_RS00470	COG1177	transmembrane transport
N186_RS00475	COG3842	ATPase activity
N186_RS00480	COG0584	glycerophosphoryl diester phosphodiesterase
N186_RS00485	COG2094	Belongs to the DNA glycosylase MPG family
N186_RS00495	COG0470	DNA polymerase III
N186_RS00495	COG1067	ATP-dependent peptidase activity
N186_RS00510	COG4150	thiosulfate binding
N186_RS00530	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
N186_RS00570	COG0425	Belongs to the sulfur carrier protein TusA family
N186_RS00585	COG3842	ATPase activity
N186_RS00620	COG0009	L-threonylcarbamoyladenylate synthase
N186_RS00635	COG0477	Major facilitator Superfamily
N186_RS00665	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
N186_RS00675	COG2217	Heavy metal translocating P-type atpase
N186_RS00740	COG2033	superoxide reductase activity
N186_RS00760	COG0017	Asparaginyl-tRNA synthetase
N186_RS00775	COG1528	Iron-storage protein
N186_RS00785	COG4948	Mandelate Racemase Muconate Lactonizing
N186_RS00795	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
N186_RS00815	COG1363	Peptidase, m42
N186_RS00820	COG1592	Rubrerythrin
N186_RS00825	COG1522	sequence-specific DNA binding
N186_RS00850	COG2814	Major facilitator Superfamily
N186_RS00855	COG1122	ATPase activity
N186_RS00860	COG1122	ATPase activity
N186_RS00865	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
N186_RS00880	COG0563	adenylate kinase activity
N186_RS00915	COG3613	nucleoside 2-deoxyribosyltransferase
N186_RS00920	COG1522	sequence-specific DNA binding
N186_RS00965	COG0436	Aminotransferase
N186_RS01040	COG0312	modulator of DNA gyrase
N186_RS01045	COG0312	modulator of DNA gyrase
N186_RS01100	COG0531	amino acid
N186_RS01190	COG0402	S-adenosylhomocysteine deaminase activity
N186_RS01195	COG0813	purine-nucleoside phosphorylase activity
N186_RS01205	COG0813	purine-nucleoside phosphorylase activity
N186_RS01215	COG4720	Psort location CytoplasmicMembrane, score
N186_RS01230	COG1122	ATPase activity
N186_RS01265	COG2084	Dehydrogenase
N186_RS01305	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
N186_RS01340	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
N186_RS01345	COG2414	aldehyde ferredoxin oxidoreductase
N186_RS01400	COG3433	isochorismatase activity
N186_RS01400	COG1535	isochorismatase
N186_RS01405	COG4974	Belongs to the 'phage' integrase family
N186_RS01425	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
N186_RS01435	COG0148	phosphopyruvate hydratase activity
N186_RS01440	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
N186_RS01465	COG0084	hydrolase, TatD family'
N186_RS01470	COG0439	Biotin carboxylase
N186_RS01475	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
N186_RS01480	COG0803	Belongs to the bacterial solute-binding protein 9 family
N186_RS01505	COG0813	purine-nucleoside phosphorylase activity
N186_RS01530	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
N186_RS01565	COG3276	selenocysteine insertion sequence binding
N186_RS01580	COG0717	Belongs to the dCTP deaminase family
N186_RS01595	COG0446	pyridine nucleotide-disulphide oxidoreductase
N186_RS01605	COG4608	Belongs to the ABC transporter superfamily
N186_RS01610	COG0444	Belongs to the ABC transporter superfamily
N186_RS01625	COG0747	negative chemotaxis
N186_RS01650	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
N186_RS01660	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
N186_RS01685	COG0003	Pfam Anion-transporting ATPase
N186_RS01700	COG0714	Associated with various cellular activities
N186_RS01715	COG0563	adenylate kinase activity
N186_RS01740	COG0549	Belongs to the carbamate kinase family
N186_RS01755	COG2414	aldehyde ferredoxin oxidoreductase
N186_RS01765	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
N186_RS01775	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
N186_RS01775	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
N186_RS01785	COG1980	fructose-bisphosphate aldolase activity
N186_RS01790	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
N186_RS01840	COG2379	hydroxypyruvate reductase
N186_RS01860	COG0488	(ABC) transporter
N186_RS01880	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
N186_RS01885	COG0430	RNA-3'-phosphate cyclase activity
N186_RS01890	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
N186_RS01900	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
N186_RS01910	COG0081	regulation of translation
N186_RS01915	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
N186_RS01920	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
N186_RS01925	COG1252	NADH dehydrogenase
N186_RS01930	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
N186_RS01935	COG0089	rRNA binding
N186_RS01945	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
N186_RS02025	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
N186_RS02045	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
N186_RS02050	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
N186_RS02060	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
N186_RS02070	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
N186_RS02080	COG0006	proline dipeptidase activity
N186_RS02115	COG0436	Aminotransferase
N186_RS02125	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
N186_RS02130	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
N186_RS02135	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
N186_RS02150	COG4948	Mandelate Racemase Muconate Lactonizing
N186_RS02165	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
N186_RS02165	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
N186_RS02170	COG2255	four-way junction helicase activity
N186_RS02175	COG0049	tRNA binding
N186_RS02200	COG1355	regulation of microtubule-based process
N186_RS02205	COG0052	Belongs to the universal ribosomal protein uS2 family
N186_RS02225	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
N186_RS02230	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
N186_RS02255	COG1358	cellular component organization or biogenesis
N186_RS02260	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
N186_RS02265	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
N186_RS02270	COG0085	RNA polymerase activity
N186_RS02295	COG0423	glycine-tRNA ligase activity
N186_RS02310	COG0864	Transcriptional regulator
N186_RS02325	COG0459	protein refolding
N186_RS02340	COG1247	-acetyltransferase
N186_RS02360	COG0417	DNA replication proofreading
N186_RS02440	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
N186_RS02445	COG1047	Peptidyl-prolyl cis-trans
N186_RS02460	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
N186_RS02465	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
N186_RS02480	COG0521	Mo-molybdopterin cofactor biosynthetic process
N186_RS02500	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
N186_RS02505	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
N186_RS02515	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
N186_RS02520	COG2234	aminopeptidase activity
N186_RS02525	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
N186_RS02525	COG0301	tRNA thio-modification
N186_RS02545	COG0525	valine-tRNA ligase activity
N186_RS02555	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
N186_RS02570	COG0469	pyruvate kinase activity
N186_RS02595	COG1328	CTP reductase activity
N186_RS02600	COG1042	CoA-binding domain protein
N186_RS02600	COG0045	succinate-CoA ligase (ADP-forming) activity
N186_RS02600	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
N186_RS02605	COG1269	ATP hydrolysis coupled proton transport
N186_RS02630	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
N186_RS02650	COG0501	Belongs to the peptidase M48B family
N186_RS02710	COG0343	queuine tRNA-ribosyltransferase activity
N186_RS02730	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
N186_RS02775	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
N186_RS02790	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
N186_RS02815	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
N186_RS02845	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
N186_RS02850	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
N186_RS02855	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
N186_RS02880	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
N186_RS02960	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
N186_RS02975	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
N186_RS02980	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
N186_RS02995	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
N186_RS03045	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
N186_RS03050	COG1793	dna ligase
N186_RS03060	COG3276	selenocysteine insertion sequence binding
N186_RS03065	COG0552	protein localization to endoplasmic reticulum
N186_RS03065	COG0457	Tetratricopeptide repeat
N186_RS03120	COG1144	Oxidoreductase
N186_RS03125	COG0674	pyruvate-flavodoxin oxidoreductase activity
N186_RS03130	COG1013	pyruvate-flavodoxin oxidoreductase activity
N186_RS03135	COG1110	DNA topoisomerase II activity
N186_RS03140	COG1056	cytidyltransferase-related domain
N186_RS03140	COG1051	belongs to the nudix hydrolase family
N186_RS03150	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
N186_RS03250	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
N186_RS03270	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
N186_RS03280	COG1522	sequence-specific DNA binding
N186_RS03290	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
N186_RS03295	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
N186_RS03315	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
N186_RS03360	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
N186_RS03365	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
N186_RS03370	COG1078	dGTPase activity
N186_RS03375	COG0071	Belongs to the small heat shock protein (HSP20) family
N186_RS03380	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
N186_RS03395	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
N186_RS03430	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
N186_RS03435	COG0045	succinate-CoA ligase (ADP-forming) activity
N186_RS03440	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
N186_RS03445	COG0528	UMP kinase activity
N186_RS03455	COG2264	protein methyltransferase activity
N186_RS03470	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
N186_RS03475	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
N186_RS03495	COG1192	Involved in chromosome partitioning
N186_RS03555	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
N186_RS03585	COG1201	RNA secondary structure unwinding
N186_RS03635	COG2226	methyltransferase
N186_RS03665	COG1773	rubredoxin
N186_RS03665	COG0426	domain, Protein
N186_RS03670	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
N186_RS03690	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
N186_RS03715	COG1358	cellular component organization or biogenesis
N186_RS03720	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
N186_RS03720	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
N186_RS03735	COG1185	polyribonucleotide nucleotidyltransferase activity
N186_RS03745	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
N186_RS03780	COG0419	ATPase involved in DNA repair
N186_RS03870	COG0731	radical SAM domain protein
N186_RS03870	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
N186_RS03915	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
N186_RS03920	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
N186_RS03970	COG1122	ATPase activity
N186_RS04010	COG0674	pyruvate-flavodoxin oxidoreductase activity
N186_RS04015	COG1013	pyruvate-flavodoxin oxidoreductase activity
N186_RS04025	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
N186_RS04075	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
N186_RS04155	COG0180	Tryptophanyl-tRNA synthetase
N186_RS04160	COG0574	Belongs to the PEP-utilizing enzyme family
N186_RS04160	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
N186_RS04165	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
N186_RS04180	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
N186_RS04195	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
N186_RS04200	COG0411	ABC transporter
N186_RS04205	COG0410	ABC transporter
N186_RS04210	COG0559	Belongs to the binding-protein-dependent transport system permease family
N186_RS04220	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
N186_RS04220	COG1042	CoA-binding domain protein
N186_RS04220	COG0045	succinate-CoA ligase (ADP-forming) activity
N186_RS04225	COG0432	Pfam Uncharacterised protein family UPF0047
N186_RS04230	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
N186_RS04245	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
N186_RS04260	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
N186_RS04270	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
N186_RS04280	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
N186_RS04285	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
N186_RS04290	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
N186_RS04295	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
N186_RS04310	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
N186_RS04310	COG1793	dna ligase
N186_RS04340	COG0017	Asparaginyl-tRNA synthetase
N186_RS04360	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
N186_RS04410	COG0051	transcription antitermination factor activity, RNA binding
N186_RS04435	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
N186_RS04465	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
N186_RS04470	COG0124	histidyl-tRNA synthetase
N186_RS04475	COG2222	sugar isomerase
N186_RS04505	COG1234	tRNA 3'-trailer cleavage
N186_RS04540	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
N186_RS04540	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
N186_RS04545	COG1515	deoxyribonuclease V activity
N186_RS04555	COG0024	Methionine aminopeptidase
N186_RS04570	COG0585	pseudouridine synthase activity
N186_RS04575	COG1444	tRNA N-acetyltransferase activity
N186_RS04585	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
N186_RS04650	COG0784	Response regulator, receiver
N186_RS04650	COG2205	protein histidine kinase activity
N186_RS04655	COG0175	sulfate reduction
N186_RS04710	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
N186_RS04735	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
N186_RS04755	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
N186_RS04760	COG1122	ATPase activity
N186_RS04765	COG1122	ATPase activity
N186_RS04770	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
N186_RS04790	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
N186_RS04825	COG1192	Involved in chromosome partitioning
N186_RS04885	COG1812	S-adenosylmethionine synthetase (AdoMet synthetase)
N186_RS04950	COG2078	PFAM AMMECR1 domain protein
N186_RS04960	COG1793	dna ligase
N186_RS04980	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
N186_RS05005	COG0517	IMP dehydrogenase activity
N186_RS05005	COG0516	GMP reductase activity
N186_RS05015	COG0519	Catalyzes the synthesis of GMP from XMP
N186_RS05015	COG0518	GMP synthase (glutamine-hydrolyzing) activity
N186_RS05030	COG1254	Belongs to the acylphosphatase family
N186_RS05040	COG0303	'Molybdopterin
N186_RS05045	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
N186_RS05060	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
N186_RS05075	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
N186_RS05085	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
N186_RS05090	COG2814	Major facilitator Superfamily
N186_RS05110	COG0310	cobalt ion transport
N186_RS05125	COG0109	protoheme IX farnesyltransferase activity
N186_RS05165	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
N186_RS05170	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
N186_RS05180	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
N186_RS05195	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
N186_RS05220	COG0126	phosphoglycerate kinase activity
N186_RS05245	COG1574	metal-dependent hydrolase with the TIM-barrel fold
N186_RS05320	COG1573	uracil-dna glycosylase
N186_RS05355	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
N186_RS05380	COG2835	tetraacyldisaccharide 4'-kinase activity
N186_RS05385	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
N186_RS05420	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
N186_RS05430	COG0438	transferase activity, transferring glycosyl groups
N186_RS05435	COG1449	Belongs to the glycosyl hydrolase 57 family
N186_RS05445	COG0442	prolyl-tRNA aminoacylation
N186_RS05450	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
N186_RS05455	COG1234	tRNA 3'-trailer cleavage
N186_RS05460	COG1082	Xylose isomerase domain protein TIM barrel
N186_RS05465	COG1063	alcohol dehydrogenase
N186_RS05470	COG1402	creatininase
N186_RS05475	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
N186_RS05480	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
N186_RS05495	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
N186_RS05500	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
N186_RS05535	COG0330	HflC and HflK could
N186_RS05555	COG1830	Aldolase
N186_RS05580	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
N186_RS05590	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
N186_RS05605	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
N186_RS05615	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
N186_RS05620	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
N186_RS05625	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
N186_RS05640	COG0551	DNA topoisomerase type I activity
N186_RS05640	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
N186_RS05665	COG0149	triose-phosphate isomerase activity
N186_RS05715	COG2151	metal-sulfur cluster biosynthetic enzyme
N186_RS05730	COG2255	four-way junction helicase activity
N186_RS05750	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
N186_RS05760	COG0513	Belongs to the DEAD box helicase family
N186_RS05765	COG2264	protein methyltransferase activity
N186_RS05770	COG0017	Asparaginyl-tRNA synthetase
N186_RS05790	COG2814	Major facilitator Superfamily
N186_RS05800	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
N186_RS05815	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
N186_RS05815	COG0674	pyruvate-flavodoxin oxidoreductase activity
N186_RS05850	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
N186_RS05865	COG1940	carbohydrate kinase activity
N186_RS05880	COG0215	cysteine-tRNA ligase activity
N186_RS05890	COG1126	abc transporter atp-binding protein
N186_RS05910	COG0489	protein tyrosine kinase activity
N186_RS05920	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
N186_RS05925	COG1177	transmembrane transport
N186_RS05930	COG1176	ABC-type spermidine putrescine transport system, permease component I
N186_RS05935	COG3842	ATPase activity
N186_RS05950	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
N186_RS05985	COG0037	tRNA processing
N186_RS06025	COG1201	RNA secondary structure unwinding
N186_RS06120	COG0656	L-ascorbic acid biosynthetic process
N186_RS06140	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
N186_RS06145	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
N186_RS06165	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
N186_RS06215	COG0673	inositol 2-dehydrogenase activity
N186_RS06220	COG1201	RNA secondary structure unwinding
N186_RS06270	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
N186_RS06275	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
N186_RS06335	COG0456	acetyltransferase
N186_RS06345	COG3260	NADH ubiquinone oxidoreductase 20
N186_RS06350	COG3261	NADH dehydrogenase
N186_RS06350	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
N186_RS06360	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
N186_RS06375	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
N186_RS06380	COG0651	ATP synthesis coupled electron transport
N186_RS06390	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
N186_RS06395	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
N186_RS06400	COG0649	NAD binding
N186_RS06405	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
N186_RS06420	COG0713	ATP synthesis coupled electron transport
N186_RS06425	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
N186_RS06430	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
N186_RS06435	COG1007	ATP synthesis coupled electron transport
N186_RS06440	COG0174	glutamine synthetase
N186_RS06445	COG0693	protein deglycase activity
N186_RS06450	COG4821	SIS domain
N186_RS06455	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
N186_RS06470	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
N186_RS06490	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
N186_RS06500	COG3716	PTS system mannose fructose sorbose family IID component
N186_RS06505	COG0561	phosphatase activity
N186_RS06510	COG3037	sugar-specific permease SgaT UlaA
N186_RS06520	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
N186_RS06525	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
N186_RS06540	COG1122	ATPase activity
N186_RS06555	COG2723	6-phospho-beta-galactosidase activity
N186_RS06565	COG1085	galactose-1-phosphate uridylyltransferase
N186_RS06630	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
N186_RS06655	COG0395	ABC-type sugar transport system, permease component
N186_RS06660	COG3842	ATPase activity
N186_RS06670	COG2431	L-lysine efflux transmembrane transporter activity
N186_RS06700	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
N186_RS06705	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
N186_RS06710	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
N186_RS06720	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
N186_RS06725	COG1070	Carbohydrate kinase
N186_RS06745	COG1175	transmembrane transport
N186_RS06750	COG0395	ABC-type sugar transport system, permease component
N186_RS06755	COG1070	Carbohydrate kinase
N186_RS06770	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
N186_RS06775	COG0540	Belongs to the ATCase OTCase family
N186_RS06780	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
N186_RS06785	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
N186_RS06790	COG0543	2 iron, 2 sulfur cluster binding
N186_RS06795	COG0167	dihydroorotate dehydrogenase activity
N186_RS06800	COG1418	mRNA catabolic process
N186_RS06805	COG0504	CTP synthase activity
N186_RS06810	COG3842	ATPase activity
N186_RS06830	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
N186_RS06845	COG1131	(ABC) transporter
N186_RS06860	COG2095	MarC family integral membrane protein
N186_RS06875	COG0543	2 iron, 2 sulfur cluster binding
N186_RS06880	COG0493	'glutamate synthase
N186_RS06880	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
N186_RS06910	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
N186_RS06920	COG0531	amino acid
N186_RS06960	COG0396	ATPase activity
N186_RS06980	COG4214	carbohydrate transport
N186_RS07000	COG5012	cobalamin binding
N186_RS07040	COG0501	Belongs to the peptidase M48B family
N186_RS07060	COG1131	(ABC) transporter
N186_RS07090	COG0667	Aldo Keto reductase
N186_RS07095	COG1850	ribulose-bisphosphate carboxylase activity
N186_RS07105	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
N186_RS07170	COG0864	Transcriptional regulator
N186_RS07175	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
N186_RS07180	COG0277	FAD linked oxidase domain protein
N186_RS07195	COG0446	pyridine nucleotide-disulphide oxidoreductase
N186_RS07195	COG0404	The glycine cleavage system catalyzes the degradation of glycine
N186_RS07205	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
N186_RS07240	COG1175	transmembrane transport
N186_RS07245	COG3833	ABC-type maltose transport systems, permease component
N186_RS07250	COG3842	ATPase activity
N186_RS07255	COG1378	Sugar-specific transcriptional regulator TrmB
N186_RS07265	COG1554	hydrolase, family 65, central catalytic
N186_RS07275	COG0778	Nitroreductase
N186_RS07290	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
N186_RS07295	COG1830	Aldolase
N186_RS07300	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
N186_RS07300	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
N186_RS07305	COG0805	protein transport
N186_RS07315	COG0805	protein transport
N186_RS07330	COG2095	MarC family integral membrane protein
N186_RS07345	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
N186_RS07350	COG0747	negative chemotaxis
N186_RS07355	COG0601	transmembrane transport
N186_RS07360	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
N186_RS07365	COG0444	Belongs to the ABC transporter superfamily
N186_RS07370	COG4608	Belongs to the ABC transporter superfamily
N186_RS07385	COG0243	molybdopterin cofactor binding
N186_RS07405	COG0471	metal ion transport
N186_RS07410	COG0409	Hydrogenase expression formation protein
N186_RS07420	COG0309	Hydrogenase expression formation protein (HypE)
N186_RS07440	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
N186_RS07450	COG1342	Belongs to the UPF0251 family
N186_RS07485	COG2211	Major facilitator Superfamily
N186_RS07500	COG0586	Pfam SNARE associated Golgi protein
N186_RS07515	COG0668	transmembrane transport
N186_RS07550	COG0395	ABC-type sugar transport system, permease component
N186_RS07590	COG1598	PFAM Uncharacterised protein family UPF0150
N186_RS07595	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
N186_RS07620	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
N186_RS07690	COG1088	dTDP-glucose 4,6-dehydratase activity
N186_RS07695	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
N186_RS07750	COG1215	transferase activity, transferring glycosyl groups
N186_RS07755	COG0438	transferase activity, transferring glycosyl groups
N186_RS07765	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
N186_RS07770	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
N186_RS07835	COG1598	PFAM Uncharacterised protein family UPF0150
N186_RS07865	COG1373	ATPase (AAA superfamily
N186_RS07935	COG1216	Glycosyl transferase, family 2
N186_RS07935	COG1442	glycosyl transferase family 8
N186_RS07955	COG0489	protein tyrosine kinase activity
N186_RS07985	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
N186_RS08020	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
N186_RS08060	COG0395	ABC-type sugar transport system, permease component
N186_RS08105	COG0714	Associated with various cellular activities
N186_RS08150	COG5012	cobalamin binding
N186_RS08170	COG0243	molybdopterin cofactor binding
N186_RS08195	COG2267	carboxylic ester hydrolase activity
N186_RS08235	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
N186_RS08255	COG1136	(ABC) transporter
N186_RS08260	COG0577	efflux transmembrane transporter activity
N186_RS08260	COG1136	(ABC) transporter
N186_RS08280	COG1131	(ABC) transporter
N186_RS08360	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
N186_RS08485	COG0438	transferase activity, transferring glycosyl groups
N186_RS08490	COG1378	Sugar-specific transcriptional regulator TrmB
N186_RS08495	COG1131	(ABC) transporter
N186_RS08500	COG0842	Transport permease protein
N186_RS08520	COG1063	alcohol dehydrogenase
N186_RS08530	COG0531	amino acid
N186_RS08540	COG1486	melibiose metabolic process
N186_RS08590	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
N186_RS08610	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
N186_RS08630	COG0534	Mate efflux family protein
N186_RS08650	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
N186_RS08660	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
N186_RS08680	COG4690	dipeptidase activity
N186_RS08720	COG2814	Major facilitator Superfamily
N186_RS08725	COG0402	S-adenosylhomocysteine deaminase activity
N186_RS08730	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
N186_RS08745	COG1122	ATPase activity
N186_RS08750	COG1122	ATPase activity
N186_RS08755	COG0436	Aminotransferase
N186_RS08810	COG1028	Short-chain dehydrogenase reductase Sdr
N186_RS08900	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
N186_RS08950	COG0471	metal ion transport
N186_RS08985	COG1872	DUF167
N186_RS08990	COG4608	Belongs to the ABC transporter superfamily
N186_RS08995	COG0444	Belongs to the ABC transporter superfamily
N186_RS09005	COG0601	transmembrane transport
N186_RS09035	COG0698	ribose 5-phosphate isomerase
N186_RS09040	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
N186_RS09100	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
N186_RS09125	COG1575	Belongs to the MenA family. Type 1 subfamily
N186_RS09130	COG0535	radical SAM domain protein
N186_RS09140	COG0456	acetyltransferase
N186_RS09140	COG1214	PFAM Peptidase M22, glycoprotease
N186_RS09145	COG1546	Belongs to the CinA family
N186_RS09145	COG1058	Belongs to the CinA family
N186_RS09210	COG0450	alkyl hydroperoxide reductase
N186_RS09240	COG0419	ATPase involved in DNA repair
N186_RS09265	COG0730	response to heat
N186_RS09275	COG0411	ABC transporter
N186_RS09295	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
N186_RS09305	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
N186_RS09320	COG0410	ABC transporter
N186_RS09325	COG0411	ABC transporter
N186_RS09340	COG0318	PFAM AMP-dependent synthetase and ligase
N186_RS09350	COG1028	Short-chain dehydrogenase reductase Sdr
N186_RS09355	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
N186_RS09370	COG0045	succinate-CoA ligase (ADP-forming) activity
N186_RS09370	COG1042	CoA-binding domain protein
N186_RS09370	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
N186_RS09375	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
N186_RS09375	COG0045	succinate-CoA ligase (ADP-forming) activity
N186_RS09375	COG1042	CoA-binding domain protein
N186_RS09380	COG1793	dna ligase
N186_RS09380	COG3285	dna ligase
N186_RS09440	COG1598	PFAM Uncharacterised protein family UPF0150