locus-tag	class	description
TPEN_RS00010	COG1363	Peptidase, m42
TPEN_RS00020	COG2814	Major facilitator Superfamily
TPEN_RS00025	COG1122	ATPase activity
TPEN_RS00030	COG1122	ATPase activity
TPEN_RS00035	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
TPEN_RS00050	COG0563	adenylate kinase activity
TPEN_RS00090	COG3613	nucleoside 2-deoxyribosyltransferase
TPEN_RS00140	COG0436	Aminotransferase
TPEN_RS00220	COG0312	modulator of DNA gyrase
TPEN_RS00225	COG0312	modulator of DNA gyrase
TPEN_RS00240	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
TPEN_RS00260	COG0730	response to heat
TPEN_RS00270	COG0531	amino acid
TPEN_RS00300	COG0402	S-adenosylhomocysteine deaminase activity
TPEN_RS00305	COG0813	purine-nucleoside phosphorylase activity
TPEN_RS00315	COG0813	purine-nucleoside phosphorylase activity
TPEN_RS00340	COG1122	ATPase activity
TPEN_RS00345	COG4721	ABC-type cobalt transport system, permease component
TPEN_RS00410	COG0436	Aminotransferase
TPEN_RS00425	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
TPEN_RS00460	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
TPEN_RS00465	COG2414	aldehyde ferredoxin oxidoreductase
TPEN_RS00510	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TPEN_RS00510	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TPEN_RS00525	COG4974	Belongs to the 'phage' integrase family
TPEN_RS00545	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
TPEN_RS00555	COG0148	phosphopyruvate hydratase activity
TPEN_RS00575	COG0500	methyltransferase
TPEN_RS00585	COG0084	hydrolase, TatD family'
TPEN_RS00590	COG0439	Biotin carboxylase
TPEN_RS00595	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
TPEN_RS00605	COG1121	(ABC) transporter
TPEN_RS00625	COG0813	purine-nucleoside phosphorylase activity
TPEN_RS00645	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
TPEN_RS00695	COG0717	Belongs to the dCTP deaminase family
TPEN_RS00700	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
TPEN_RS00705	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
TPEN_RS00710	COG0446	pyridine nucleotide-disulphide oxidoreductase
TPEN_RS00720	COG4608	Belongs to the ABC transporter superfamily
TPEN_RS00725	COG0444	Belongs to the ABC transporter superfamily
TPEN_RS00735	COG0601	transmembrane transport
TPEN_RS00745	COG1522	sequence-specific DNA binding
TPEN_RS00770	COG0511	ligase activity, forming carbon-carbon bonds
TPEN_RS00770	COG5016	pyruvate
TPEN_RS00775	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
TPEN_RS00800	COG0003	Pfam Anion-transporting ATPase
TPEN_RS00815	COG0714	Associated with various cellular activities
TPEN_RS00830	COG0563	adenylate kinase activity
TPEN_RS00875	COG2414	aldehyde ferredoxin oxidoreductase
TPEN_RS00895	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
TPEN_RS00900	COG3260	NADH ubiquinone oxidoreductase 20
TPEN_RS00905	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TPEN_RS00910	COG3261	NADH dehydrogenase
TPEN_RS00910	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
TPEN_RS00915	COG0651	ATP synthesis coupled electron transport
TPEN_RS00920	COG0651	ATP synthesis coupled electron transport
TPEN_RS00930	COG0650	Formate hydrogenlyase subunit 4
TPEN_RS00935	COG0651	ATP synthesis coupled electron transport
TPEN_RS00945	COG3383	formate dehydrogenase (NAD+) activity
TPEN_RS00950	COG2116	formate transmembrane transporter activity
TPEN_RS00965	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
TPEN_RS00965	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
TPEN_RS00975	COG1980	fructose-bisphosphate aldolase activity
TPEN_RS00980	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
TPEN_RS00995	COG0483	inositol monophosphate 1-phosphatase activity
TPEN_RS01030	COG2379	hydroxypyruvate reductase
TPEN_RS01055	COG1121	(ABC) transporter
TPEN_RS01080	COG0430	RNA-3'-phosphate cyclase activity
TPEN_RS01085	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
TPEN_RS01100	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
TPEN_RS01105	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
TPEN_RS01110	COG0081	regulation of translation
TPEN_RS01115	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
TPEN_RS01120	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
TPEN_RS01125	COG1252	NADH dehydrogenase
TPEN_RS01130	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
TPEN_RS01145	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
TPEN_RS01165	COG0200	Binds to the 23S rRNA
TPEN_RS01195	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
TPEN_RS01205	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
TPEN_RS01215	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
TPEN_RS01225	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
TPEN_RS01235	COG0006	proline dipeptidase activity
TPEN_RS01270	COG0436	Aminotransferase
TPEN_RS01280	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
TPEN_RS01285	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
TPEN_RS01290	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
TPEN_RS01315	COG4948	Mandelate Racemase Muconate Lactonizing
TPEN_RS01330	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
TPEN_RS01330	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
TPEN_RS01335	COG2255	four-way junction helicase activity
TPEN_RS01360	COG1304	FMN binding
TPEN_RS01365	COG1355	regulation of microtubule-based process
TPEN_RS01370	COG0052	Belongs to the universal ribosomal protein uS2 family
TPEN_RS01395	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
TPEN_RS01425	COG1358	cellular component organization or biogenesis
TPEN_RS01430	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
TPEN_RS01435	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
TPEN_RS01440	COG0085	RNA polymerase activity
TPEN_RS01450	COG0423	glycine-tRNA ligase activity
TPEN_RS01480	COG0459	protein refolding
TPEN_RS01495	COG1247	-acetyltransferase
TPEN_RS01515	COG0417	DNA replication proofreading
TPEN_RS01550	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
TPEN_RS01560	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
TPEN_RS01570	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
TPEN_RS01585	COG0521	Mo-molybdopterin cofactor biosynthetic process
TPEN_RS01590	COG0315	cyclic pyranopterin monophosphate synthase activity
TPEN_RS01605	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
TPEN_RS01610	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
TPEN_RS01615	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
TPEN_RS01620	COG2234	aminopeptidase activity
TPEN_RS01625	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
TPEN_RS01625	COG0301	tRNA thio-modification
TPEN_RS01665	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
TPEN_RS01680	COG0469	pyruvate kinase activity
TPEN_RS01710	COG0045	succinate-CoA ligase (ADP-forming) activity
TPEN_RS01710	COG1042	CoA-binding domain protein
TPEN_RS01710	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
TPEN_RS01715	COG1269	ATP hydrolysis coupled proton transport
TPEN_RS01735	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
TPEN_RS01740	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
TPEN_RS01755	COG0501	Belongs to the peptidase M48B family
TPEN_RS01815	COG0343	queuine tRNA-ribosyltransferase activity
TPEN_RS01835	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
TPEN_RS01880	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
TPEN_RS01920	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
TPEN_RS01930	COG2264	protein methyltransferase activity
TPEN_RS01950	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
TPEN_RS01955	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
TPEN_RS01960	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
TPEN_RS01990	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
TPEN_RS01995	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
TPEN_RS02050	COG0617	tRNA 3'-terminal CCA addition
TPEN_RS02050	COG0517	IMP dehydrogenase activity
TPEN_RS02050	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
TPEN_RS02075	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
TPEN_RS02090	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
TPEN_RS02095	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
TPEN_RS02115	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
TPEN_RS02180	COG0492	ferredoxin-NADP+ reductase activity
TPEN_RS02180	COG3118	belongs to the thioredoxin family
TPEN_RS02185	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
TPEN_RS02185	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
TPEN_RS02190	COG1793	dna ligase
TPEN_RS02200	COG0457	Tetratricopeptide repeat
TPEN_RS02200	COG0552	protein localization to endoplasmic reticulum
TPEN_RS02275	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
TPEN_RS02290	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
TPEN_RS02305	COG0071	Belongs to the small heat shock protein (HSP20) family
TPEN_RS02330	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
TPEN_RS02360	COG1078	dGTPase activity
TPEN_RS02385	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
TPEN_RS02470	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
TPEN_RS02485	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
TPEN_RS02510	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
TPEN_RS02530	COG0255	Belongs to the universal ribosomal protein uL29 family
TPEN_RS02535	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
TPEN_RS02540	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
TPEN_RS02550	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
TPEN_RS02555	COG1358	cellular component organization or biogenesis
TPEN_RS02560	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
TPEN_RS02560	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
TPEN_RS02585	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
TPEN_RS02600	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
TPEN_RS02605	COG1773	rubredoxin
TPEN_RS02605	COG0426	domain, Protein
TPEN_RS02610	COG0071	Belongs to the small heat shock protein (HSP20) family
TPEN_RS02615	COG0023	Translation Initiation Factor
TPEN_RS02640	COG0010	Belongs to the arginase family
TPEN_RS02670	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
TPEN_RS02670	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
TPEN_RS02675	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
TPEN_RS02680	COG0045	succinate-CoA ligase (ADP-forming) activity
TPEN_RS02685	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
TPEN_RS02690	COG0528	UMP kinase activity
TPEN_RS02700	COG2264	protein methyltransferase activity
TPEN_RS02715	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
TPEN_RS02720	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
TPEN_RS02735	COG0419	ATPase involved in DNA repair
TPEN_RS02795	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
TPEN_RS02810	COG0674	pyruvate-flavodoxin oxidoreductase activity
TPEN_RS02815	COG1013	pyruvate-flavodoxin oxidoreductase activity
TPEN_RS02825	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
TPEN_RS02830	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
TPEN_RS02920	COG0018	arginyl-trna synthetase
TPEN_RS02935	COG0495	leucyl-tRNA aminoacylation
TPEN_RS02945	COG0123	including yeast histone deacetylase and acetoin utilization protein
TPEN_RS02950	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
TPEN_RS02955	COG0674	pyruvate-flavodoxin oxidoreductase activity
TPEN_RS02960	COG1013	pyruvate-flavodoxin oxidoreductase activity
TPEN_RS02970	COG1110	DNA topoisomerase II activity
TPEN_RS02975	COG1056	cytidyltransferase-related domain
TPEN_RS02975	COG1051	belongs to the nudix hydrolase family
TPEN_RS03000	COG1522	sequence-specific DNA binding
TPEN_RS03010	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
TPEN_RS03020	COG1185	polyribonucleotide nucleotidyltransferase activity
TPEN_RS03065	COG0180	Tryptophanyl-tRNA synthetase
TPEN_RS03095	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
TPEN_RS03110	COG0375	protein maturation
TPEN_RS03115	COG0489	protein tyrosine kinase activity
TPEN_RS03120	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
TPEN_RS03130	COG1137	ATPase activity
TPEN_RS03145	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
TPEN_RS03145	COG1042	CoA-binding domain protein
TPEN_RS03145	COG0045	succinate-CoA ligase (ADP-forming) activity
TPEN_RS03170	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
TPEN_RS03180	COG0251	oxidation-reduction process
TPEN_RS03185	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
TPEN_RS03195	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
TPEN_RS03205	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TPEN_RS03210	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TPEN_RS03215	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
TPEN_RS03220	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
TPEN_RS03230	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
TPEN_RS03235	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
TPEN_RS03235	COG1793	dna ligase
TPEN_RS03260	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
TPEN_RS03265	COG0017	Asparaginyl-tRNA synthetase
TPEN_RS03285	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
TPEN_RS03325	COG1185	polyribonucleotide nucleotidyltransferase activity
TPEN_RS03345	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
TPEN_RS03350	COG0051	transcription antitermination factor activity, RNA binding
TPEN_RS03375	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
TPEN_RS03405	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
TPEN_RS03410	COG0124	histidyl-tRNA synthetase
TPEN_RS03415	COG2222	sugar isomerase
TPEN_RS03440	COG0175	sulfate reduction
TPEN_RS03510	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
TPEN_RS03515	COG0024	Methionine aminopeptidase
TPEN_RS03525	COG1515	deoxyribonuclease V activity
TPEN_RS03540	COG0585	pseudouridine synthase activity
TPEN_RS03545	COG1444	tRNA N-acetyltransferase activity
TPEN_RS03555	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
TPEN_RS03555	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
TPEN_RS03640	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
TPEN_RS03665	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
TPEN_RS03685	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
TPEN_RS03690	COG1122	ATPase activity
TPEN_RS03695	COG3845	ABC transporter
TPEN_RS03700	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
TPEN_RS03710	COG0673	inositol 2-dehydrogenase activity
TPEN_RS03820	COG1812	S-adenosylmethionine synthetase (AdoMet synthetase)
TPEN_RS03840	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
TPEN_RS03875	COG2078	PFAM AMMECR1 domain protein
TPEN_RS03885	COG1793	dna ligase
TPEN_RS03895	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
TPEN_RS03905	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
TPEN_RS03945	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
TPEN_RS03960	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
TPEN_RS04000	COG0126	phosphoglycerate kinase activity
TPEN_RS04025	COG1574	metal-dependent hydrolase with the TIM-barrel fold
TPEN_RS04090	COG1449	Belongs to the glycosyl hydrolase 57 family
TPEN_RS04095	COG0438	transferase activity, transferring glycosyl groups
TPEN_RS04105	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
TPEN_RS04125	COG1573	uracil-dna glycosylase
TPEN_RS04180	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
TPEN_RS04205	COG2835	tetraacyldisaccharide 4'-kinase activity
TPEN_RS04210	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
TPEN_RS04220	COG0442	prolyl-tRNA aminoacylation
TPEN_RS04225	COG0456	acetyltransferase
TPEN_RS04230	COG1234	tRNA 3'-trailer cleavage
TPEN_RS04235	COG1082	Xylose isomerase domain protein TIM barrel
TPEN_RS04240	COG1063	alcohol dehydrogenase
TPEN_RS04245	COG1402	creatininase
TPEN_RS04250	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
TPEN_RS04255	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
TPEN_RS04265	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
TPEN_RS04270	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
TPEN_RS04295	COG0330	HflC and HflK could
TPEN_RS04315	COG1830	Aldolase
TPEN_RS04340	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
TPEN_RS04365	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
TPEN_RS04370	COG0017	Asparaginyl-tRNA synthetase
TPEN_RS04380	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
TPEN_RS04380	COG1918	ferrous iron import across plasma membrane
TPEN_RS04400	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
TPEN_RS04415	COG0674	pyruvate-flavodoxin oxidoreductase activity
TPEN_RS04415	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
TPEN_RS04440	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
TPEN_RS04510	COG2151	metal-sulfur cluster biosynthetic enzyme
TPEN_RS04545	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
TPEN_RS04580	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
TPEN_RS04600	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TPEN_RS04605	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
TPEN_RS04615	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
TPEN_RS04625	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
TPEN_RS04630	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
TPEN_RS04645	COG0215	cysteine-tRNA ligase activity
TPEN_RS04655	COG1126	abc transporter atp-binding protein
TPEN_RS04660	COG0765	amino acid transport
TPEN_RS04675	COG0489	protein tyrosine kinase activity
TPEN_RS04685	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
TPEN_RS04690	COG1177	transmembrane transport
TPEN_RS04700	COG3842	ATPase activity
TPEN_RS04715	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
TPEN_RS04750	COG0037	tRNA processing
TPEN_RS04790	COG1201	RNA secondary structure unwinding
TPEN_RS04870	COG0656	L-ascorbic acid biosynthetic process
TPEN_RS04875	COG1881	PFAM PEBP family protein
TPEN_RS04895	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
TPEN_RS05015	COG1321	iron dependent repressor
TPEN_RS05030	COG1918	ferrous iron import across plasma membrane
TPEN_RS05030	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
TPEN_RS05080	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
TPEN_RS05090	COG1192	Involved in chromosome partitioning
TPEN_RS05105	COG0393	Putative heavy-metal-binding
TPEN_RS05140	COG0489	protein tyrosine kinase activity
TPEN_RS05180	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
TPEN_RS05205	COG0537	adenosine 5'-monophosphoramidase activity
TPEN_RS05225	COG0673	inositol 2-dehydrogenase activity
TPEN_RS05230	COG1201	RNA secondary structure unwinding
TPEN_RS05275	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
TPEN_RS05290	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
TPEN_RS05310	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
TPEN_RS05360	COG0109	protoheme IX farnesyltransferase activity
TPEN_RS05365	COG2816	NAD+ diphosphatase activity
TPEN_RS05375	COG2814	Major facilitator Superfamily
TPEN_RS05380	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
TPEN_RS05390	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
TPEN_RS05420	COG1254	Belongs to the acylphosphatase family
TPEN_RS05435	COG2182	Extracellular solute-binding protein
TPEN_RS05440	COG1175	transmembrane transport
TPEN_RS05445	COG3833	ABC-type maltose transport systems, permease component
TPEN_RS05455	COG0573	inorganic phosphate transmembrane transporter activity
TPEN_RS05460	COG0581	inorganic phosphate transmembrane transporter activity
TPEN_RS05465	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
TPEN_RS05470	COG0519	Catalyzes the synthesis of GMP from XMP
TPEN_RS05470	COG0518	GMP synthase (glutamine-hydrolyzing) activity
TPEN_RS05480	COG0516	GMP reductase activity
TPEN_RS05480	COG0517	IMP dehydrogenase activity
TPEN_RS05505	COG0704	Plays a role in the regulation of phosphate uptake
TPEN_RS05510	COG3260	NADH ubiquinone oxidoreductase 20
TPEN_RS05515	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TPEN_RS05515	COG0649	NAD binding
TPEN_RS05525	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
TPEN_RS05540	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
TPEN_RS05545	COG0651	ATP synthesis coupled electron transport
TPEN_RS05555	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TPEN_RS05560	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TPEN_RS05565	COG0649	NAD binding
TPEN_RS05585	COG0713	ATP synthesis coupled electron transport
TPEN_RS05590	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TPEN_RS05595	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
TPEN_RS05600	COG1007	ATP synthesis coupled electron transport
TPEN_RS05605	COG0174	glutamine synthetase
TPEN_RS05610	COG4821	SIS domain
TPEN_RS05615	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
TPEN_RS05620	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
TPEN_RS05630	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
TPEN_RS05640	COG0673	inositol 2-dehydrogenase activity
TPEN_RS05650	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
TPEN_RS05660	COG3716	PTS system mannose fructose sorbose family IID component
TPEN_RS05670	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
TPEN_RS05685	COG1122	ATPase activity
TPEN_RS05710	COG2723	6-phospho-beta-galactosidase activity
TPEN_RS05720	COG1085	galactose-1-phosphate uridylyltransferase
TPEN_RS05730	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
TPEN_RS05755	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
TPEN_RS05770	COG0437	4 iron, 4 sulfur cluster binding
TPEN_RS05795	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
TPEN_RS05830	COG2431	L-lysine efflux transmembrane transporter activity
TPEN_RS05840	COG1131	(ABC) transporter
TPEN_RS05860	COG0017	Asparaginyl-tRNA synthetase
TPEN_RS05865	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
TPEN_RS05900	COG0284	orotidine-5'-phosphate decarboxylase activity
TPEN_RS05905	COG0284	orotidine-5'-phosphate decarboxylase activity
TPEN_RS05905	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
TPEN_RS05910	COG3842	ATPase activity
TPEN_RS05915	COG3833	ABC-type maltose transport systems, permease component
TPEN_RS05940	COG1554	hydrolase, family 65, central catalytic
TPEN_RS05950	COG0540	Belongs to the ATCase OTCase family
TPEN_RS05955	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
TPEN_RS05960	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
TPEN_RS05965	COG0543	2 iron, 2 sulfur cluster binding
TPEN_RS05970	COG0167	dihydroorotate dehydrogenase activity
TPEN_RS05975	COG1418	mRNA catabolic process
TPEN_RS05980	COG0504	CTP synthase activity
TPEN_RS05990	COG3842	ATPase activity
TPEN_RS06005	COG1305	Transglutaminase-like
TPEN_RS06025	COG1131	(ABC) transporter
TPEN_RS06045	COG3833	ABC-type maltose transport systems, permease component
TPEN_RS06060	COG1575	Belongs to the MenA family. Type 1 subfamily
TPEN_RS06065	COG0535	radical SAM domain protein
TPEN_RS06085	COG2095	MarC family integral membrane protein
TPEN_RS06125	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
TPEN_RS06140	COG0531	amino acid
TPEN_RS06155	COG0644	oxidoreductase
TPEN_RS06185	COG0396	ATPase activity
TPEN_RS06225	COG5012	cobalamin binding
TPEN_RS06255	COG0501	Belongs to the peptidase M48B family
TPEN_RS06270	COG1131	(ABC) transporter
TPEN_RS06300	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TPEN_RS06315	COG0371	Dehydrogenase
TPEN_RS06325	COG0546	phosphoglycolate phosphatase activity
TPEN_RS06340	COG0864	Transcriptional regulator
TPEN_RS06345	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
TPEN_RS06365	COG0698	ribose 5-phosphate isomerase
TPEN_RS06390	COG0601	transmembrane transport
TPEN_RS06395	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TPEN_RS06400	COG0444	Belongs to the ABC transporter superfamily
TPEN_RS06405	COG4608	Belongs to the ABC transporter superfamily
TPEN_RS06410	COG1213	nucleotidyl transferase
TPEN_RS06410	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
TPEN_RS06440	COG1175	transmembrane transport
TPEN_RS06445	COG1653	transport
TPEN_RS06450	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
TPEN_RS06470	COG1373	ATPase (AAA superfamily
TPEN_RS06485	COG1892	Catalyzes the irreversible beta-carboxylation of phosphoenolpyruvate (PEP) to form oxaloacetate (OAA), a four- carbon dicarboxylic acid source for the tricarboxylic acid cycle
TPEN_RS06500	COG0037	tRNA processing
TPEN_RS06520	COG1234	tRNA 3'-trailer cleavage
TPEN_RS06530	COG1131	(ABC) transporter
TPEN_RS06705	COG2971	BadF BadG BcrA BcrD
TPEN_RS06835	COG1131	(ABC) transporter
TPEN_RS06890	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
TPEN_RS06915	COG1473	amidohydrolase
TPEN_RS06925	COG1201	RNA secondary structure unwinding
TPEN_RS07030	COG0277	FAD linked oxidase domain protein
TPEN_RS07035	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
TPEN_RS07045	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
TPEN_RS07050	COG1546	Belongs to the CinA family
TPEN_RS07050	COG1058	Belongs to the CinA family
TPEN_RS07080	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
TPEN_RS07105	COG2267	carboxylic ester hydrolase activity
TPEN_RS07145	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
TPEN_RS07170	COG1131	(ABC) transporter
TPEN_RS07185	COG0577	efflux transmembrane transporter activity
TPEN_RS07185	COG1136	(ABC) transporter
TPEN_RS07190	COG1136	(ABC) transporter
TPEN_RS07215	COG0437	4 iron, 4 sulfur cluster binding
TPEN_RS07255	COG0436	Aminotransferase
TPEN_RS07265	COG1131	(ABC) transporter
TPEN_RS07295	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TPEN_RS07305	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
TPEN_RS07320	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
TPEN_RS07400	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
TPEN_RS07405	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
TPEN_RS07405	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
TPEN_RS07435	COG3833	ABC-type maltose transport systems, permease component
TPEN_RS07440	COG1175	transmembrane transport
TPEN_RS07455	COG1013	pyruvate-flavodoxin oxidoreductase activity
TPEN_RS07465	COG1773	rubredoxin
TPEN_RS07490	COG1131	(ABC) transporter
TPEN_RS07520	COG5012	cobalamin binding
TPEN_RS07575	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
TPEN_RS07600	COG0598	Magnesium transport protein CorA
TPEN_RS07620	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
TPEN_RS07620	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
TPEN_RS07635	COG1268	BioY protein
TPEN_RS07640	COG0668	transmembrane transport
TPEN_RS07645	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
TPEN_RS07650	COG1472	Belongs to the glycosyl hydrolase 3 family
TPEN_RS07735	COG1486	melibiose metabolic process
TPEN_RS07820	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TPEN_RS07830	COG0396	ATPase activity
TPEN_RS07835	COG0719	Fe-S assembly protein
TPEN_RS07835	COG1372	Participates in initiation and elongation during chromosome replication
TPEN_RS07845	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
TPEN_RS07850	COG4720	Psort location CytoplasmicMembrane, score
TPEN_RS07855	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
TPEN_RS07865	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
TPEN_RS07885	COG1122	ATPase activity
TPEN_RS07900	COG1122	ATPase activity
TPEN_RS07905	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
TPEN_RS07945	COG3842	ATPase activity
TPEN_RS07995	COG0471	metal ion transport
TPEN_RS08005	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
TPEN_RS08010	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
TPEN_RS08025	COG0450	alkyl hydroperoxide reductase
TPEN_RS08045	COG0419	ATPase involved in DNA repair
TPEN_RS08050	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
TPEN_RS08070	COG0411	ABC transporter
TPEN_RS08080	COG0584	glycerophosphoryl diester phosphodiesterase
TPEN_RS08105	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
TPEN_RS08115	COG1653	transport
TPEN_RS08120	COG1175	transmembrane transport
TPEN_RS08125	COG0395	ABC-type sugar transport system, permease component
TPEN_RS08135	COG0438	transferase activity, transferring glycosyl groups
TPEN_RS08170	COG2211	Major facilitator Superfamily
TPEN_RS08205	COG1592	Rubrerythrin
TPEN_RS08230	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TPEN_RS08250	COG0409	Hydrogenase expression formation protein
TPEN_RS08255	COG1070	Carbohydrate kinase
TPEN_RS08265	COG1175	transmembrane transport
TPEN_RS08275	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
TPEN_RS08285	COG1070	Carbohydrate kinase
TPEN_RS08290	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
TPEN_RS08325	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
TPEN_RS08330	COG0243	molybdopterin cofactor binding
TPEN_RS08345	COG4608	Belongs to the ABC transporter superfamily
TPEN_RS08350	COG0444	Belongs to the ABC transporter superfamily
TPEN_RS08355	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TPEN_RS08360	COG0601	transmembrane transport
TPEN_RS08365	COG0747	negative chemotaxis
TPEN_RS08375	COG0531	amino acid
TPEN_RS08380	COG0477	Major facilitator Superfamily
TPEN_RS08385	COG2095	MarC family integral membrane protein
TPEN_RS08400	COG0805	protein transport
TPEN_RS08410	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
TPEN_RS08410	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
TPEN_RS08415	COG1830	Aldolase
TPEN_RS08420	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
TPEN_RS08435	COG0778	Nitroreductase
TPEN_RS08440	COG2814	Major facilitator Superfamily
TPEN_RS08440	COG0477	Major facilitator Superfamily
TPEN_RS08495	COG0436	Aminotransferase
TPEN_RS08505	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
TPEN_RS08510	COG0709	Synthesizes selenophosphate from selenide and ATP
TPEN_RS08525	COG0667	Aldo Keto reductase
TPEN_RS08560	COG0601	transmembrane transport
TPEN_RS08570	COG0444	Belongs to the ABC transporter superfamily
TPEN_RS08575	COG4608	Belongs to the ABC transporter superfamily
TPEN_RS08590	COG0477	Major facilitator Superfamily
TPEN_RS08730	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
TPEN_RS08740	COG1404	Belongs to the peptidase S8 family
TPEN_RS08765	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
TPEN_RS08770	COG1210	Utp--glucose-1-phosphate uridylyltransferase
TPEN_RS08785	COG0438	transferase activity, transferring glycosyl groups
TPEN_RS08800	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
TPEN_RS08825	COG1215	transferase activity, transferring glycosyl groups
TPEN_RS08885	COG1122	ATPase activity
TPEN_RS08895	COG0438	transferase activity, transferring glycosyl groups
TPEN_RS08905	COG0438	transferase activity, transferring glycosyl groups
TPEN_RS08925	COG0714	Associated with various cellular activities
TPEN_RS08975	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
TPEN_RS08975	COG0731	radical SAM domain protein
TPEN_RS08985	COG0513	Belongs to the DEAD box helicase family
TPEN_RS08990	COG1342	Belongs to the UPF0251 family
TPEN_RS09005	COG0493	'glutamate synthase
TPEN_RS09035	COG0301	tRNA thio-modification
TPEN_RS09035	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
TPEN_RS09050	COG1136	(ABC) transporter
TPEN_RS09055	COG4591	ABC-type transport system involved in lipoprotein release permease component
TPEN_RS09105	COG0584	glycerophosphoryl diester phosphodiesterase
TPEN_RS09110	COG0470	DNA polymerase III
TPEN_RS09110	COG1067	ATP-dependent peptidase activity
TPEN_RS09130	COG2094	Belongs to the DNA glycosylase MPG family
TPEN_RS09190	COG0425	Belongs to the sulfur carrier protein TusA family
TPEN_RS09205	COG3842	ATPase activity
TPEN_RS09240	COG0009	L-threonylcarbamoyladenylate synthase
TPEN_RS09250	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
TPEN_RS09250	COG0617	tRNA 3'-terminal CCA addition
TPEN_RS09250	COG3620	sequence-specific DNA binding
TPEN_RS09265	COG1489	DNA binding
TPEN_RS09275	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
TPEN_RS09280	COG1028	Short-chain dehydrogenase reductase Sdr
TPEN_RS09285	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
TPEN_RS09325	COG2033	superoxide reductase activity
TPEN_RS09340	COG0017	Asparaginyl-tRNA synthetase
TPEN_RS09360	COG4948	Mandelate Racemase Muconate Lactonizing
TPEN_RS09370	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
TPEN_RS09550	COG0556	nucleotide-excision repair
TPEN_RS09630	COG4974	Belongs to the 'phage' integrase family