locus-tag	class	description
THTE_RS00005	COG0592	DNA-directed DNA polymerase activity
THTE_RS00015	COG0187	DNA topoisomerase II activity
THTE_RS00025	COG1309	transcriptional regulator
THTE_RS00035	COG1131	(ABC) transporter
THTE_RS00040	COG0842	Transport permease protein
THTE_RS00045	COG0842	Transport permease protein
THTE_RS00070	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
THTE_RS00115	COG0443	Heat shock 70 kDa protein
THTE_RS00155	COG1305	Transglutaminase-like
THTE_RS00160	COG0793	Belongs to the peptidase S41A family
THTE_RS00180	COG0149	triose-phosphate isomerase activity
THTE_RS00190	COG1561	YicC-like family, N-terminal region
THTE_RS00195	COG0194	GDP metabolic process
THTE_RS00200	COG1758	RNA polymerase activity
THTE_RS00205	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
THTE_RS00210	COG1959	2 iron, 2 sulfur cluster binding
THTE_RS00215	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
THTE_RS00225	COG1013	pyruvate-flavodoxin oxidoreductase activity
THTE_RS00230	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
THTE_RS00230	COG0674	pyruvate-flavodoxin oxidoreductase activity
THTE_RS00235	COG2239	Acts as a magnesium transporter
THTE_RS00245	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
THTE_RS00255	COG0124	histidyl-tRNA synthetase
THTE_RS00275	COG0129	dihydroxy-acid dehydratase activity
THTE_RS00295	COG3494	Protein of unknown function (DUF1009)
THTE_RS00300	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
THTE_RS00305	COG0529	Catalyzes the synthesis of activated sulfate
THTE_RS00315	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
THTE_RS00330	COG3119	arylsulfatase activity
THTE_RS00335	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
THTE_RS00360	COG1940	carbohydrate kinase activity
THTE_RS00365	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
THTE_RS00390	COG2078	PFAM AMMECR1 domain protein
THTE_RS00390	COG3885	ferrous iron binding
THTE_RS00400	COG0564	pseudouridine synthase activity
THTE_RS00405	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
THTE_RS00410	COG3119	arylsulfatase activity
THTE_RS00420	COG0138	bifunctional purine biosynthesis protein purh
THTE_RS00435	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
THTE_RS00465	COG0233	cytoplasmic translational termination
THTE_RS00470	COG0528	UMP kinase activity
THTE_RS00475	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
THTE_RS00480	COG0052	Belongs to the universal ribosomal protein uS2 family
THTE_RS00515	COG0318	PFAM AMP-dependent synthetase and ligase
THTE_RS00540	COG1643	Atp-dependent helicase
THTE_RS00570	COG0095	Lipoate-protein ligase
THTE_RS00595	COG0247	lactate metabolic process
THTE_RS00600	COG1139	Iron-sulfur cluster binding protein
THTE_RS00605	COG1556	Lactate utilization protein
THTE_RS00615	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
THTE_RS00635	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
THTE_RS00640	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
THTE_RS00650	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
THTE_RS00655	COG0047	phosphoribosylformylglycinamidine synthase activity
THTE_RS00670	COG0228	four-way junction DNA binding
THTE_RS00675	COG0336	Belongs to the RNA methyltransferase TrmD family
THTE_RS00680	COG0335	large ribosomal subunit rRNA binding
THTE_RS00685	COG0792	nuclease activity
THTE_RS00690	COG1366	Belongs to the anti-sigma-factor antagonist family
THTE_RS00705	COG3119	arylsulfatase activity
THTE_RS00710	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
THTE_RS00720	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
THTE_RS00725	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
THTE_RS00780	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
THTE_RS00795	COG1082	Xylose isomerase domain protein TIM barrel
THTE_RS00810	COG0285	dihydrofolate synthase activity
THTE_RS00855	COG1131	(ABC) transporter
THTE_RS00865	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
THTE_RS00870	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
THTE_RS00885	COG3852	Histidine kinase
THTE_RS00890	COG0385	Bile acid
THTE_RS00900	COG3604	Transcriptional regulator
THTE_RS00905	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
THTE_RS00910	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
THTE_RS00920	COG1573	uracil-dna glycosylase
THTE_RS00925	COG2244	polysaccharide biosynthetic process
THTE_RS00930	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
THTE_RS00940	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
THTE_RS00955	COG0303	'Molybdopterin
THTE_RS00960	COG0315	cyclic pyranopterin monophosphate synthase activity
THTE_RS00965	COG0315	cyclic pyranopterin monophosphate synthase activity
THTE_RS00965	COG0521	Mo-molybdopterin cofactor biosynthetic process
THTE_RS00970	COG0746	molybdenum cofactor guanylyltransferase activity
THTE_RS01035	COG1234	tRNA 3'-trailer cleavage
THTE_RS01055	COG0440	acetolactate synthase activity
THTE_RS01060	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
THTE_RS01070	COG0309	Hydrogenase expression formation protein (HypE)
THTE_RS01080	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
THTE_RS01110	COG0673	inositol 2-dehydrogenase activity
THTE_RS01120	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
THTE_RS01145	COG4968	Prepilin-type N-terminal cleavage methylation domain
THTE_RS01150	COG1459	type II secretion system
THTE_RS01155	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
THTE_RS01165	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
THTE_RS01170	COG0267	Belongs to the bacterial ribosomal protein bL33 family
THTE_RS01175	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
THTE_RS01175	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
THTE_RS01190	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
THTE_RS01190	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
THTE_RS01195	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
THTE_RS01225	COG1181	Belongs to the D-alanine--D-alanine ligase family
THTE_RS01230	COG1181	Belongs to the D-alanine--D-alanine ligase family
THTE_RS01245	COG0017	Asparaginyl-tRNA synthetase
THTE_RS01250	COG0492	ferredoxin-NADP+ reductase activity
THTE_RS01265	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
THTE_RS01275	COG0010	Belongs to the arginase family
THTE_RS01295	COG0835	chemotaxis
THTE_RS01300	COG0585	pseudouridine synthase activity
THTE_RS01305	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
THTE_RS01330	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
THTE_RS01345	COG3875	lactate racemase activity
THTE_RS01350	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
THTE_RS01395	COG1785	Belongs to the alkaline phosphatase family
THTE_RS01440	COG1971	Probably functions as a manganese efflux pump
THTE_RS01450	COG0129	dihydroxy-acid dehydratase activity
THTE_RS01455	COG1385	rRNA (uridine-N3-)-methyltransferase activity
THTE_RS01465	COG1994	Peptidase M50
THTE_RS01465	COG0517	IMP dehydrogenase activity
THTE_RS01470	COG0348	domain, Protein
THTE_RS01495	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
THTE_RS01540	COG1254	Belongs to the acylphosphatase family
THTE_RS01570	COG2205	protein histidine kinase activity
THTE_RS01570	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
THTE_RS01575	COG2721	sulfolactate sulfo-lyase activity
THTE_RS01595	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
THTE_RS01610	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
THTE_RS01620	COG0527	aspartate kinase activity
THTE_RS01625	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
THTE_RS01645	COG0515	serine threonine protein kinase
THTE_RS01645	COG2815	serine threonine protein kinase
THTE_RS01665	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
THTE_RS01670	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
THTE_RS01675	COG0539	negative regulation of cytoplasmic translation
THTE_RS01695	COG2333	competence protein COMEC
THTE_RS01695	COG0658	competence protein
THTE_RS01700	COG0482	sulfurtransferase activity
THTE_RS01715	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
THTE_RS01735	COG0301	tRNA thio-modification
THTE_RS01735	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
THTE_RS01745	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
THTE_RS01780	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
THTE_RS01790	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
THTE_RS01800	COG1121	(ABC) transporter
THTE_RS01875	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
THTE_RS01885	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
THTE_RS01935	COG1381	Involved in DNA repair and RecF pathway recombination
THTE_RS01940	COG1515	deoxyribonuclease V activity
THTE_RS01945	COG0681	Belongs to the peptidase S26 family
THTE_RS01960	COG0531	amino acid
THTE_RS01970	COG0515	serine threonine protein kinase
THTE_RS01970	COG2815	serine threonine protein kinase
THTE_RS02010	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
THTE_RS02020	COG2814	Major facilitator Superfamily
THTE_RS02035	COG1196	nuclear chromosome segregation
THTE_RS02040	COG2033	superoxide reductase activity
THTE_RS02055	COG0298	carbon dioxide binding
THTE_RS02060	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
THTE_RS02065	COG1663	tetraacyldisaccharide 4'-kinase activity
THTE_RS02095	COG0515	serine threonine protein kinase
THTE_RS02095	COG1262	PFAM Formylglycine-generating sulfatase enzyme
THTE_RS02100	COG1070	Carbohydrate kinase
THTE_RS02115	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
THTE_RS02130	COG1136	(ABC) transporter
THTE_RS02130	COG0577	efflux transmembrane transporter activity
THTE_RS02155	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
THTE_RS02170	COG3132	Protein of unknown function, DUF480
THTE_RS02205	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
THTE_RS02210	COG0215	cysteine-tRNA ligase activity
THTE_RS02215	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
THTE_RS02220	COG3189	MarR family transcriptional regulator
THTE_RS02235	COG0175	sulfate reduction
THTE_RS02255	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
THTE_RS02265	COG0107	imidazoleglycerol-phosphate synthase activity
THTE_RS02270	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
THTE_RS02275	COG0450	alkyl hydroperoxide reductase
THTE_RS02295	COG1678	Uncharacterized ACR, COG1678
THTE_RS02305	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
THTE_RS02320	COG2814	Major facilitator Superfamily
THTE_RS02340	COG0105	UTP biosynthetic process
THTE_RS02350	COG0067	glutamate synthase
THTE_RS02350	COG0070	glutamate synthase
THTE_RS02350	COG0069	glutamate synthase activity
THTE_RS02370	COG0577	efflux transmembrane transporter activity
THTE_RS02370	COG1136	(ABC) transporter
THTE_RS02375	COG1136	(ABC) transporter
THTE_RS02390	COG0261	This protein binds to 23S rRNA in the presence of protein L20
THTE_RS02395	COG2046	Belongs to the sulfate adenylyltransferase family
THTE_RS02410	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
THTE_RS02415	COG2205	protein histidine kinase activity
THTE_RS02415	COG0784	Response regulator, receiver
THTE_RS02415	COG5002	protein histidine kinase activity
THTE_RS02430	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
THTE_RS02440	COG0477	Major facilitator Superfamily
THTE_RS02445	COG1621	beta-fructofuranosidase activity
THTE_RS02450	COG0297	glycogen (starch) synthase activity
THTE_RS02450	COG0438	transferase activity, transferring glycosyl groups
THTE_RS02455	COG0646	methionine synthase
THTE_RS02455	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
THTE_RS02485	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
THTE_RS02485	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
THTE_RS02490	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
THTE_RS02495	COG0357	Ribosomal RNA small subunit methyltransferase G
THTE_RS02505	COG2815	serine threonine protein kinase
THTE_RS02505	COG0515	serine threonine protein kinase
THTE_RS02535	COG2183	response to ionizing radiation
THTE_RS02540	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
THTE_RS02555	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
THTE_RS02565	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
THTE_RS02570	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
THTE_RS02575	COG1509	lysine 2,3-aminomutase activity
THTE_RS02580	COG4464	protein tyrosine phosphatase activity
THTE_RS02595	COG4974	Belongs to the 'phage' integrase family
THTE_RS02645	COG0494	nUDIX hydrolase
THTE_RS02680	COG0114	fumarate hydratase activity
THTE_RS02690	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
THTE_RS02695	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
THTE_RS02700	COG0649	NAD binding
THTE_RS02725	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
THTE_RS02740	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
THTE_RS02750	COG1007	ATP synthesis coupled electron transport
THTE_RS02755	COG1216	Glycosyl transferase, family 2
THTE_RS02770	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
THTE_RS02785	COG0058	SHG alpha-glucan phosphorylase activity
THTE_RS02790	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
THTE_RS02825	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
THTE_RS02830	COG1126	abc transporter atp-binding protein
THTE_RS02835	COG0765	amino acid transport
THTE_RS02875	COG1131	(ABC) transporter
THTE_RS02885	COG3119	arylsulfatase activity
THTE_RS02900	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
THTE_RS02915	COG0539	negative regulation of cytoplasmic translation
THTE_RS02930	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
THTE_RS02935	COG0750	zinc metalloprotease
THTE_RS02950	COG0575	Belongs to the CDS family
THTE_RS02970	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
THTE_RS02980	COG0557	exoribonuclease II activity
THTE_RS02995	COG3118	belongs to the thioredoxin family
THTE_RS03000	COG0542	response to heat
THTE_RS03010	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
THTE_RS03015	COG1185	polyribonucleotide nucleotidyltransferase activity
THTE_RS03020	COG3852	Histidine kinase
THTE_RS03030	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
THTE_RS03045	COG0515	serine threonine protein kinase
THTE_RS03045	COG2815	serine threonine protein kinase
THTE_RS03065	COG5012	cobalamin binding
THTE_RS03070	COG1028	Short-chain dehydrogenase reductase Sdr
THTE_RS03075	COG1166	arginine decarboxylase activity
THTE_RS03085	COG4608	Belongs to the ABC transporter superfamily
THTE_RS03090	COG0444	Belongs to the ABC transporter superfamily
THTE_RS03095	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
THTE_RS03100	COG0601	transmembrane transport
THTE_RS03100	COG0601	transmembrane transport
THTE_RS03110	COG0616	signal peptide processing
THTE_RS03115	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
THTE_RS03120	COG4208	sulfate ABC transporter
THTE_RS03125	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
THTE_RS03135	COG3604	Transcriptional regulator
THTE_RS03150	COG3119	arylsulfatase activity
THTE_RS03155	COG0402	S-adenosylhomocysteine deaminase activity
THTE_RS03165	COG4555	ABC transporter
THTE_RS03170	COG3264	Mechanosensitive ion channel
THTE_RS03170	COG1511	domain protein
THTE_RS03205	COG3119	arylsulfatase activity
THTE_RS03210	COG0534	Mate efflux family protein
THTE_RS03215	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
THTE_RS03220	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
THTE_RS03225	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
THTE_RS03230	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
THTE_RS03240	COG1966	Carbon starvation protein
THTE_RS03255	COG3940	Belongs to the glycosyl hydrolase 43 family
THTE_RS03280	COG0646	methionine synthase
THTE_RS03280	COG1410	methionine synthase
THTE_RS03300	COG0072	phenylalanine-tRNA ligase activity
THTE_RS03300	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
THTE_RS03305	COG0284	orotidine-5'-phosphate decarboxylase activity
THTE_RS03315	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
THTE_RS03320	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
THTE_RS03335	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
THTE_RS03340	COG1993	acr, cog1993
THTE_RS03350	COG0515	serine threonine protein kinase
THTE_RS03365	COG0310	cobalt ion transport
THTE_RS03370	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
THTE_RS03375	COG1122	ATPase activity
THTE_RS03425	COG0840	transmembrane signaling receptor activity
THTE_RS03430	COG4566	intracellular signal transduction
THTE_RS03440	COG4191	Histidine kinase
THTE_RS03625	COG1595	DNA-templated transcription, initiation
THTE_RS03710	COG0375	protein maturation
THTE_RS03720	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
THTE_RS03725	COG0742	ribosomal rna small subunit methyltransferase
THTE_RS03755	COG0515	serine threonine protein kinase
THTE_RS03765	COG0820	rRNA (adenine-C2-)-methyltransferase activity
THTE_RS03770	COG2255	four-way junction helicase activity
THTE_RS03790	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
THTE_RS03805	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
THTE_RS03815	COG0006	proline dipeptidase activity
THTE_RS03820	COG0511	ligase activity, forming carbon-carbon bonds
THTE_RS03825	COG0439	Biotin carboxylase
THTE_RS03830	COG0205	6-phosphofructokinase activity
THTE_RS03860	COG0864	Transcriptional regulator
THTE_RS03865	COG0217	transcriptional regulatory protein
THTE_RS03875	COG0640	Transcriptional regulator
THTE_RS03915	COG1131	(ABC) transporter
THTE_RS03920	COG1725	Transcriptional regulator
THTE_RS03935	COG3940	Belongs to the glycosyl hydrolase 43 family
THTE_RS03940	COG3209	COG3209 Rhs family protein
THTE_RS03990	COG0220	tRNA (guanine-N7-)-methyltransferase activity
THTE_RS04005	COG4191	Histidine kinase
THTE_RS04010	COG2204	response regulator
THTE_RS04025	COG1677	Flagellar hook-basal body complex protein FliE
THTE_RS04035	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
THTE_RS04045	COG1157	protein secretion by the type III secretion system
THTE_RS04065	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
THTE_RS04075	COG1582	Flagellar protein (FlbD)
THTE_RS04085	COG1360	Flagellar Motor Protein
THTE_RS04095	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
THTE_RS04105	COG1338	Plays a role in the flagellum-specific transport system
THTE_RS04110	COG1987	bacterial-type flagellum assembly
THTE_RS04115	COG1684	flagellar biosynthetic protein fliR
THTE_RS04120	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
THTE_RS04130	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
THTE_RS04140	COG1419	protein localization to endoplasmic reticulum
THTE_RS04155	COG1191	sigma factor activity
THTE_RS04195	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
THTE_RS04210	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
THTE_RS04225	COG0356	it plays a direct role in the translocation of protons across the membrane
THTE_RS04235	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
THTE_RS04240	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
THTE_RS04245	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
THTE_RS04250	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
THTE_RS04255	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
THTE_RS04260	COG0355	proton-transporting ATP synthase activity, rotational mechanism
THTE_RS04270	COG1045	serine acetyltransferase
THTE_RS04275	COG1131	(ABC) transporter
THTE_RS04285	COG0540	Belongs to the ATCase OTCase family
THTE_RS04290	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
THTE_RS04300	COG0151	Belongs to the GarS family
THTE_RS04310	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
THTE_RS04340	COG0109	protoheme IX farnesyltransferase activity
THTE_RS04360	COG0714	Associated with various cellular activities
THTE_RS04400	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
THTE_RS04405	COG0039	L-malate dehydrogenase activity
THTE_RS04440	COG0517	IMP dehydrogenase activity
THTE_RS04440	COG0516	GMP reductase activity
THTE_RS04465	COG1418	mRNA catabolic process
THTE_RS04470	COG1692	metallophosphoesterase
THTE_RS04490	COG1652	LysM domain
THTE_RS04500	COG1862	Preprotein translocase
THTE_RS04550	COG0459	protein refolding
THTE_RS04555	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
THTE_RS04595	COG3119	arylsulfatase activity
THTE_RS04605	COG3119	arylsulfatase activity
THTE_RS04610	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
THTE_RS04690	COG0515	serine threonine protein kinase
THTE_RS04690	COG2815	serine threonine protein kinase
THTE_RS04700	COG2877	3-deoxy-8-phosphooctulonate synthase activity
THTE_RS04715	COG0254	rRNA binding
THTE_RS04720	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
THTE_RS04725	COG2890	protein-(glutamine-N5) methyltransferase activity
THTE_RS04755	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
THTE_RS04785	COG0848	biopolymer transport protein
THTE_RS04790	COG0848	biopolymer transport protein
THTE_RS04795	COG0811	peptide transport
THTE_RS04810	COG2890	protein-(glutamine-N5) methyltransferase activity
THTE_RS04815	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
THTE_RS04820	COG0438	transferase activity, transferring glycosyl groups
THTE_RS04830	COG0367	asparagine synthase
THTE_RS04835	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
THTE_RS04845	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
THTE_RS04850	COG0165	Argininosuccinate lyase
THTE_RS04860	COG2204	response regulator
THTE_RS04870	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
THTE_RS04875	COG2201	protein-glutamate methylesterase activity
THTE_RS04905	COG1349	DNA-binding transcription factor activity
THTE_RS04910	COG4869	propanediol catabolic process
THTE_RS04920	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
THTE_RS04925	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
THTE_RS04930	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
THTE_RS04955	COG0235	Class ii aldolase
THTE_RS04975	COG0606	chelatase, subunit chli
THTE_RS04985	COG0698	ribose 5-phosphate isomerase
THTE_RS04995	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
THTE_RS05045	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
THTE_RS05065	COG0673	inositol 2-dehydrogenase activity
THTE_RS05070	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
THTE_RS05070	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
THTE_RS05080	COG0495	leucyl-tRNA aminoacylation
THTE_RS05085	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
THTE_RS05100	COG1082	Xylose isomerase domain protein TIM barrel
THTE_RS05105	COG0840	transmembrane signaling receptor activity
THTE_RS05110	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
THTE_RS05115	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
THTE_RS05120	COG1450	Type ii and iii secretion system protein
THTE_RS05140	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
THTE_RS05170	COG3104	oligopeptide transport
THTE_RS05175	COG0051	transcription antitermination factor activity, RNA binding
THTE_RS05180	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
THTE_RS05185	COG0088	Forms part of the polypeptide exit tunnel
THTE_RS05190	COG0089	rRNA binding
THTE_RS05195	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
THTE_RS05200	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
THTE_RS05205	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
THTE_RS05210	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
THTE_RS05215	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
THTE_RS05220	COG0255	Belongs to the universal ribosomal protein uL29 family
THTE_RS05225	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
THTE_RS05230	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
THTE_RS05235	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
THTE_RS05240	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
THTE_RS05250	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
THTE_RS05255	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
THTE_RS05260	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
THTE_RS05265	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
THTE_RS05270	COG0200	Binds to the 23S rRNA
THTE_RS05280	COG0563	adenylate kinase activity
THTE_RS05295	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
THTE_RS05300	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
THTE_RS05310	COG0202	RNA polymerase activity
THTE_RS05315	COG0203	ribosomal protein L17
THTE_RS05355	COG0704	Plays a role in the regulation of phosphate uptake
THTE_RS05385	COG3119	arylsulfatase activity
THTE_RS05425	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
THTE_RS05455	COG1151	hydroxylamine reductase activity
THTE_RS05470	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
THTE_RS05475	COG0220	tRNA (guanine-N7-)-methyltransferase activity
THTE_RS05520	COG0358	DNA primase activity
THTE_RS05535	COG1199	ATP-dependent helicase activity
THTE_RS05590	COG3119	arylsulfatase activity
THTE_RS05605	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
THTE_RS05610	COG3401	FG-GAP repeat protein
THTE_RS05620	COG2095	MarC family integral membrane protein
THTE_RS05640	COG3386	PFAM SMP-30 Gluconolaconase
THTE_RS05655	COG0714	Associated with various cellular activities
THTE_RS05695	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
THTE_RS05710	COG0723	plastoquinol--plastocyanin reductase activity
THTE_RS05715	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
THTE_RS05715	COG0493	'glutamate synthase
THTE_RS05720	COG1959	2 iron, 2 sulfur cluster binding
THTE_RS05750	COG2181	nitrate reductase activity
THTE_RS05750	COG0247	lactate metabolic process
THTE_RS05765	COG2181	nitrate reductase activity
THTE_RS05765	COG0247	lactate metabolic process
THTE_RS05780	COG1620	l-lactate permease
THTE_RS05815	COG1337	RAMP superfamily
THTE_RS05890	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
THTE_RS05890	COG1793	dna ligase
THTE_RS05905	COG3119	arylsulfatase activity
THTE_RS05930	COG1477	protein flavinylation
THTE_RS05950	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
THTE_RS05960	COG1388	LysM domain
THTE_RS05965	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
THTE_RS06000	COG0179	Fumarylacetoacetate (FAA) hydrolase
THTE_RS06010	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
THTE_RS06025	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
THTE_RS06045	COG0673	inositol 2-dehydrogenase activity
THTE_RS06060	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
THTE_RS06070	COG0673	inositol 2-dehydrogenase activity
THTE_RS06075	COG1595	DNA-templated transcription, initiation
THTE_RS06085	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
THTE_RS06110	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
THTE_RS06115	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
THTE_RS06160	COG0443	Heat shock 70 kDa protein
THTE_RS06170	COG0793	Belongs to the peptidase S41A family
THTE_RS06180	COG1070	Carbohydrate kinase
THTE_RS06200	COG0354	folic acid binding
THTE_RS06250	COG1459	type II secretion system
THTE_RS06275	COG2022	thiamine diphosphate biosynthetic process
THTE_RS06310	COG2207	Transcriptional regulator
THTE_RS06310	COG1609	Transcriptional regulator
THTE_RS06340	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
THTE_RS06360	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
THTE_RS06380	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
THTE_RS06385	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
THTE_RS06390	COG0649	NAD binding
THTE_RS06395	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
THTE_RS06400	COG0839	Belongs to the complex I subunit 6 family
THTE_RS06410	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
THTE_RS06420	COG1007	ATP synthesis coupled electron transport
THTE_RS06430	COG0084	hydrolase, TatD family'
THTE_RS06435	COG0326	Molecular chaperone. Has ATPase activity
THTE_RS06445	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
THTE_RS06450	COG1078	dGTPase activity
THTE_RS06470	COG0552	protein localization to endoplasmic reticulum
THTE_RS06475	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
THTE_RS06485	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
THTE_RS06490	COG0237	dephospho-CoA kinase activity
THTE_RS06495	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
THTE_RS06495	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
THTE_RS06505	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
THTE_RS06510	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
THTE_RS06510	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
THTE_RS06520	COG1335	isochorismatase
THTE_RS06530	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
THTE_RS06535	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
THTE_RS06535	COG0517	IMP dehydrogenase activity
THTE_RS06540	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
THTE_RS06550	COG1355	regulation of microtubule-based process
THTE_RS06560	COG3174	membrane
THTE_RS06585	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
THTE_RS06655	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
THTE_RS06820	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
THTE_RS06830	COG1028	Short-chain dehydrogenase reductase Sdr
THTE_RS06835	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
THTE_RS06840	COG0653	protein targeting
THTE_RS06845	COG1519	Transferase
THTE_RS06865	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
THTE_RS06870	COG2759	Belongs to the formate--tetrahydrofolate ligase family
THTE_RS06875	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
THTE_RS06920	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
THTE_RS06925	COG1459	type II secretion system
THTE_RS06930	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
THTE_RS06940	COG1210	Utp--glucose-1-phosphate uridylyltransferase
THTE_RS06950	COG1074	ATP-dependent DNA helicase activity
THTE_RS06960	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
THTE_RS06985	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
THTE_RS06990	COG0436	Aminotransferase
THTE_RS07010	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
THTE_RS07015	COG1490	D-aminoacyl-tRNA deacylase activity
THTE_RS07025	COG0825	malonyl-CoA metabolic process
THTE_RS07040	COG0101	tRNA pseudouridine synthase activity
THTE_RS07045	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
THTE_RS07070	COG0561	phosphatase activity
THTE_RS07095	COG2146	nitrite reductase [NAD(P)H] activity
THTE_RS07100	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
THTE_RS07105	COG0166	Belongs to the GPI family
THTE_RS07120	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
THTE_RS07155	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
THTE_RS07170	COG5002	protein histidine kinase activity
THTE_RS07190	COG0573	inorganic phosphate transmembrane transporter activity
THTE_RS07205	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
THTE_RS07215	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
THTE_RS07245	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
THTE_RS07250	COG1482	cell wall glycoprotein biosynthetic process
THTE_RS07255	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
THTE_RS07260	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
THTE_RS07295	COG2204	response regulator
THTE_RS07300	COG5000	phosphorelay sensor kinase activity
THTE_RS07315	COG5002	protein histidine kinase activity
THTE_RS07330	COG2204	response regulator
THTE_RS07340	COG0515	serine threonine protein kinase
THTE_RS07340	COG2815	serine threonine protein kinase
THTE_RS07350	COG0028	Belongs to the TPP enzyme family
THTE_RS07365	COG2738	Putative neutral zinc metallopeptidase
THTE_RS07370	COG0673	inositol 2-dehydrogenase activity
THTE_RS07400	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
THTE_RS07405	COG1657	PFAM Prenyltransferase squalene oxidase
THTE_RS07410	COG0673	inositol 2-dehydrogenase activity
THTE_RS07445	COG1131	(ABC) transporter
THTE_RS07450	COG0473	3-isopropylmalate dehydrogenase activity
THTE_RS07465	COG0673	inositol 2-dehydrogenase activity
THTE_RS07480	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
THTE_RS07485	COG0116	Belongs to the methyltransferase superfamily
THTE_RS07485	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
THTE_RS07505	COG0745	RESPONSE REGULATOR receiver
THTE_RS07515	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
THTE_RS07520	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
THTE_RS07530	COG0488	(ABC) transporter
THTE_RS07535	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
THTE_RS07540	COG1960	acyl-CoA dehydrogenase activity
THTE_RS07545	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
THTE_RS07550	COG2086	electron transfer activity
THTE_RS07580	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
THTE_RS07585	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
THTE_RS07595	COG1722	exodeoxyribonuclease VII activity
THTE_RS07600	COG0519	Catalyzes the synthesis of GMP from XMP
THTE_RS07600	COG0518	GMP synthase (glutamine-hydrolyzing) activity
THTE_RS07605	COG0148	phosphopyruvate hydratase activity
THTE_RS07630	COG0673	inositol 2-dehydrogenase activity
THTE_RS07640	COG3119	arylsulfatase activity
THTE_RS07645	COG0673	inositol 2-dehydrogenase activity
THTE_RS07650	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
THTE_RS07665	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
THTE_RS07700	COG1570	exodeoxyribonuclease VII activity
THTE_RS07705	COG0811	peptide transport
THTE_RS07730	COG0673	inositol 2-dehydrogenase activity
THTE_RS07735	COG0302	gtp cyclohydrolase
THTE_RS07740	COG0247	lactate metabolic process
THTE_RS07750	COG0776	regulation of translation
THTE_RS07760	COG0167	dihydroorotate dehydrogenase activity
THTE_RS07765	COG0180	Tryptophanyl-tRNA synthetase
THTE_RS07770	COG0736	holo-[acyl-carrier-protein] synthase activity
THTE_RS07785	COG3869	Catalyzes the specific phosphorylation of arginine residues in
THTE_RS07790	COG3119	arylsulfatase activity
THTE_RS07810	COG0423	glycine-tRNA ligase activity
THTE_RS07820	COG0438	transferase activity, transferring glycosyl groups
THTE_RS07830	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
THTE_RS07840	COG3119	arylsulfatase activity
THTE_RS07875	COG5012	cobalamin binding
THTE_RS07895	COG3119	arylsulfatase activity
THTE_RS07935	COG3119	arylsulfatase activity
THTE_RS07955	COG0243	molybdopterin cofactor binding
THTE_RS07995	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
THTE_RS08000	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
THTE_RS08005	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
THTE_RS08010	COG3360	Dodecin
THTE_RS08015	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
THTE_RS08030	COG0077	Prephenate dehydratase
THTE_RS08030	COG1605	Chorismate mutase
THTE_RS08065	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
THTE_RS08070	COG3250	beta-galactosidase activity
THTE_RS08085	COG3250	beta-galactosidase activity
THTE_RS08100	COG3345	alpha-galactosidase
THTE_RS08110	COG2115	Belongs to the xylose isomerase family
THTE_RS08115	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
THTE_RS08125	COG0842	Transport permease protein
THTE_RS08125	COG1131	(ABC) transporter
THTE_RS08125	COG1716	ATPase activity
THTE_RS08135	COG0515	serine threonine protein kinase
THTE_RS08180	COG0494	nUDIX hydrolase
THTE_RS08195	COG0658	competence protein
THTE_RS08195	COG2333	competence protein COMEC
THTE_RS08235	COG4124	Belongs to the glycosyl hydrolase 26 family
THTE_RS08255	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
THTE_RS08265	COG0471	metal ion transport
THTE_RS08265	COG3273	potassium ion transport
THTE_RS08315	COG1595	DNA-templated transcription, initiation
THTE_RS08325	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
THTE_RS08340	COG1136	(ABC) transporter
THTE_RS08350	COG0673	inositol 2-dehydrogenase activity
THTE_RS08375	COG0798	PFAM Bile acid sodium symporter
THTE_RS08380	COG0640	Transcriptional regulator
THTE_RS08385	COG0730	response to heat
THTE_RS08395	COG1846	Transcriptional regulator
THTE_RS08395	COG1940	carbohydrate kinase activity
THTE_RS08420	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
THTE_RS08430	COG0277	FAD linked oxidase domain protein
THTE_RS08435	COG0277	FAD linked oxidase domain protein
THTE_RS08450	COG3534	alpha-L-arabinofuranosidase
THTE_RS08455	COG0205	6-phosphofructokinase activity
THTE_RS08460	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
THTE_RS08465	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
THTE_RS08490	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
THTE_RS08505	COG2264	protein methyltransferase activity
THTE_RS08520	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
THTE_RS08525	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
THTE_RS08530	COG1012	belongs to the aldehyde dehydrogenase family
THTE_RS08550	COG0268	Binds directly to 16S ribosomal RNA
THTE_RS08560	COG1160	GTP binding
THTE_RS08565	COG0489	protein tyrosine kinase activity
THTE_RS08605	COG1028	Short-chain dehydrogenase reductase Sdr
THTE_RS08615	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
THTE_RS08635	COG0343	queuine tRNA-ribosyltransferase activity
THTE_RS08640	COG0202	RNA polymerase activity
THTE_RS08675	COG0706	membrane insertase activity
THTE_RS08675	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
THTE_RS08680	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
THTE_RS08685	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
THTE_RS08710	COG0587	DNA-directed DNA polymerase activity
THTE_RS08730	COG0604	alcohol dehydrogenase
THTE_RS08740	COG0673	inositol 2-dehydrogenase activity
THTE_RS08765	COG0363	glucosamine-6-phosphate deaminase activity
THTE_RS08770	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
THTE_RS08780	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
THTE_RS08790	COG3119	arylsulfatase activity
THTE_RS08805	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
THTE_RS08810	COG0564	pseudouridine synthase activity
THTE_RS08840	COG2815	serine threonine protein kinase
THTE_RS08840	COG0515	serine threonine protein kinase
THTE_RS08845	COG0563	adenylate kinase activity
THTE_RS08850	COG0438	transferase activity, transferring glycosyl groups
THTE_RS08855	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
THTE_RS08860	COG0822	iron-sulfur transferase activity
THTE_RS08865	COG0556	nucleotide-excision repair
THTE_RS08925	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
THTE_RS08930	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
THTE_RS08935	COG0673	inositol 2-dehydrogenase activity
THTE_RS08945	COG0653	protein targeting
THTE_RS08970	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
THTE_RS08980	COG3119	arylsulfatase activity
THTE_RS08985	COG3119	arylsulfatase activity
THTE_RS09065	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
THTE_RS09070	COG0438	transferase activity, transferring glycosyl groups
THTE_RS09075	COG0463	Glycosyl transferase, family 2
THTE_RS09085	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
THTE_RS09110	COG1216	Glycosyl transferase, family 2
THTE_RS09125	COG0438	transferase activity, transferring glycosyl groups
THTE_RS09135	COG0463	Glycosyl transferase, family 2
THTE_RS09140	COG0438	transferase activity, transferring glycosyl groups
THTE_RS09155	COG0438	transferase activity, transferring glycosyl groups
THTE_RS09170	COG0438	transferase activity, transferring glycosyl groups
THTE_RS09185	COG0438	transferase activity, transferring glycosyl groups
THTE_RS09200	COG1215	transferase activity, transferring glycosyl groups
THTE_RS09230	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
THTE_RS09235	COG0489	protein tyrosine kinase activity
THTE_RS09260	COG1160	GTP binding
THTE_RS09265	COG1116	anion transmembrane transporter activity
THTE_RS09280	COG3119	arylsulfatase activity
THTE_RS09305	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
THTE_RS09340	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
THTE_RS09345	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
THTE_RS09350	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
THTE_RS09365	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
THTE_RS09385	COG2201	protein-glutamate methylesterase activity
THTE_RS09410	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
THTE_RS09410	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
THTE_RS09425	COG2234	aminopeptidase activity
THTE_RS09435	COG1129	ABC transporter
THTE_RS09440	COG1172	Belongs to the binding-protein-dependent transport system permease family
THTE_RS09460	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
THTE_RS09465	COG2205	protein histidine kinase activity
THTE_RS09465	COG2202	Pas domain
THTE_RS09470	COG0328	RNA-DNA hybrid ribonuclease activity
THTE_RS09475	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
THTE_RS09480	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
THTE_RS09485	COG0109	protoheme IX farnesyltransferase activity
THTE_RS09490	COG0163	prenyltransferase activity
THTE_RS09495	COG2226	methyltransferase
THTE_RS09500	COG2045	Belongs to the ComB family
THTE_RS09510	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
THTE_RS09515	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
THTE_RS09520	COG0604	alcohol dehydrogenase
THTE_RS09525	COG0442	prolyl-tRNA aminoacylation
THTE_RS09530	COG3481	metal-dependent phosphohydrolase, HD sub domain
THTE_RS09550	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
THTE_RS09555	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
THTE_RS09565	COG0812	UDP-N-acetylmuramate dehydrogenase activity
THTE_RS09585	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
THTE_RS09590	COG0714	Associated with various cellular activities
THTE_RS09605	COG0445	tRNA wobble uridine modification
THTE_RS09615	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
THTE_RS09625	COG2201	protein-glutamate methylesterase activity
THTE_RS09635	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
THTE_RS09640	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
THTE_RS09655	COG0667	Aldo Keto reductase
THTE_RS09670	COG2193	ferroxidase activity
THTE_RS09710	COG0617	tRNA 3'-terminal CCA addition
THTE_RS09720	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
THTE_RS09735	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
THTE_RS09760	COG0443	Heat shock 70 kDa protein
THTE_RS09765	COG0443	Heat shock 70 kDa protein
THTE_RS09775	COG0066	3-isopropylmalate dehydratase activity
THTE_RS09780	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
THTE_RS09790	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
THTE_RS09805	COG1606	tRNA processing
THTE_RS09820	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
THTE_RS09835	COG0617	tRNA 3'-terminal CCA addition
THTE_RS09835	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
THTE_RS09835	COG0517	IMP dehydrogenase activity
THTE_RS09850	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
THTE_RS09880	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
THTE_RS09885	COG0133	tryptophan synthase activity
THTE_RS09890	COG0159	tryptophan synthase activity
THTE_RS09895	COG0137	argininosuccinate synthase activity
THTE_RS09905	COG1404	Belongs to the peptidase S8 family
THTE_RS09905	COG4935	Belongs to the peptidase S8 family
THTE_RS09910	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
THTE_RS09930	COG0815	Transfers the fatty acyl group on membrane lipoproteins
THTE_RS09935	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
THTE_RS09935	COG0512	Glutamine amidotransferase of anthranilate synthase
THTE_RS09940	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
THTE_RS09975	COG2204	response regulator
THTE_RS09980	COG0457	Tetratricopeptide repeat
THTE_RS10010	COG2610	gluconate transmembrane transporter activity
THTE_RS10025	COG0673	inositol 2-dehydrogenase activity
THTE_RS10030	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
THTE_RS10045	COG0424	maF-like protein
THTE_RS10050	COG0776	regulation of translation
THTE_RS10055	COG0535	radical SAM domain protein
THTE_RS10095	COG0333	Belongs to the bacterial ribosomal protein bL32 family
THTE_RS10100	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
THTE_RS10105	COG1028	Short-chain dehydrogenase reductase Sdr
THTE_RS10110	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
THTE_RS10115	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
THTE_RS10130	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
THTE_RS10135	COG1312	Catalyzes the dehydration of D-mannonate
THTE_RS10165	COG0537	adenosine 5'-monophosphoramidase activity
THTE_RS10175	COG0745	RESPONSE REGULATOR receiver
THTE_RS10190	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
THTE_RS10200	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
THTE_RS10205	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
THTE_RS10210	COG4864	UPF0365 protein
THTE_RS10215	COG0673	inositol 2-dehydrogenase activity
THTE_RS10235	COG4232	protein-disulfide reductase activity
THTE_RS10250	COG0205	6-phosphofructokinase activity
THTE_RS10260	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
THTE_RS10265	COG1028	Short-chain dehydrogenase reductase Sdr
THTE_RS10270	COG1459	type II secretion system
THTE_RS10275	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
THTE_RS10285	COG0745	RESPONSE REGULATOR receiver
THTE_RS10290	COG5002	protein histidine kinase activity
THTE_RS10350	COG2239	Acts as a magnesium transporter
THTE_RS10355	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
THTE_RS10360	COG1104	cysteine desulfurase activity
THTE_RS10365	COG1164	Oligoendopeptidase f
THTE_RS10425	COG1187	pseudouridine synthase activity
THTE_RS10430	COG0543	2 iron, 2 sulfur cluster binding
THTE_RS10455	COG0673	inositol 2-dehydrogenase activity
THTE_RS10465	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
THTE_RS10480	COG3119	arylsulfatase activity
THTE_RS10485	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
THTE_RS10490	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
THTE_RS10525	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
THTE_RS10530	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
THTE_RS10590	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
THTE_RS10675	COG0617	tRNA 3'-terminal CCA addition
THTE_RS10685	COG0446	pyridine nucleotide-disulphide oxidoreductase
THTE_RS10685	COG1902	pentaerythritol trinitrate reductase activity
THTE_RS10705	COG0584	glycerophosphoryl diester phosphodiesterase
THTE_RS10725	COG0705	Rhomboid family
THTE_RS10735	COG1073	alpha beta
THTE_RS10745	COG0758	DNA mediated transformation
THTE_RS10745	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
THTE_RS10800	COG0693	protein deglycase activity
THTE_RS10810	COG0406	alpha-ribazole phosphatase activity
THTE_RS10815	COG3119	arylsulfatase activity
THTE_RS10825	COG3267	Type II secretory pathway component ExeA
THTE_RS10825	COG3409	Peptidoglycan-binding domain 1 protein
THTE_RS10835	COG0135	phosphoribosylanthranilate isomerase activity
THTE_RS10850	COG1192	Involved in chromosome partitioning
THTE_RS10855	COG1475	DNA binding
THTE_RS10880	COG1082	Xylose isomerase domain protein TIM barrel
THTE_RS10895	COG2252	PERMEase
THTE_RS10905	COG4284	Utp--glucose-1-phosphate uridylyltransferase
THTE_RS10915	COG0673	inositol 2-dehydrogenase activity
THTE_RS10950	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
THTE_RS10985	COG0840	transmembrane signaling receptor activity
THTE_RS11005	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
THTE_RS11010	COG1506	peptidase
THTE_RS11010	COG4946	Tricorn protease homolog
THTE_RS11010	COG0823	Involved in the tonB-independent uptake of proteins
THTE_RS11030	COG5434	Belongs to the glycosyl hydrolase 28 family
THTE_RS11055	COG2197	response regulator
THTE_RS11080	COG0740	serine-type endopeptidase activity
THTE_RS11085	COG0740	serine-type endopeptidase activity
THTE_RS11090	COG0714	Associated with various cellular activities
THTE_RS11120	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
THTE_RS11135	COG3119	arylsulfatase activity
THTE_RS11145	COG3852	Histidine kinase
THTE_RS11155	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
THTE_RS11175	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
THTE_RS11190	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
THTE_RS11205	COG3119	arylsulfatase activity
THTE_RS11215	COG1082	Xylose isomerase domain protein TIM barrel
THTE_RS11225	COG0673	inositol 2-dehydrogenase activity
THTE_RS11280	COG0291	Belongs to the bacterial ribosomal protein bL35 family
THTE_RS11285	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
THTE_RS11305	COG0437	4 iron, 4 sulfur cluster binding
THTE_RS11335	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
THTE_RS11340	COG1845	cytochrome c oxidase, subunit III
THTE_RS11340	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
THTE_RS11345	COG1845	cytochrome c oxidase, subunit III
THTE_RS11370	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
THTE_RS11375	COG2267	carboxylic ester hydrolase activity
THTE_RS11390	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
THTE_RS11395	COG0745	RESPONSE REGULATOR receiver
THTE_RS11440	COG2261	transglycosylase associated protein
THTE_RS11500	COG2815	serine threonine protein kinase
THTE_RS11500	COG0515	serine threonine protein kinase
THTE_RS11520	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
THTE_RS11535	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
THTE_RS11540	COG0484	heat shock protein binding
THTE_RS11575	COG2815	serine threonine protein kinase
THTE_RS11575	COG0515	serine threonine protein kinase
THTE_RS11585	COG3119	arylsulfatase activity
THTE_RS11615	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
THTE_RS11620	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
THTE_RS11645	COG2204	response regulator
THTE_RS11680	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
THTE_RS11685	COG0799	negative regulation of ribosome biogenesis
THTE_RS11690	COG0018	arginyl-trna synthetase
THTE_RS11705	COG0443	Heat shock 70 kDa protein
THTE_RS11710	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
THTE_RS11710	COG1042	CoA-binding domain protein
THTE_RS11710	COG0045	succinate-CoA ligase (ADP-forming) activity
THTE_RS11720	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
THTE_RS11725	COG2815	serine threonine protein kinase
THTE_RS11725	COG0515	serine threonine protein kinase
THTE_RS11750	COG0446	pyridine nucleotide-disulphide oxidoreductase
THTE_RS11765	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
THTE_RS11785	COG4956	integral membrane protein (PIN domain superfamily)
THTE_RS11810	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
THTE_RS11815	COG0569	domain protein
THTE_RS11820	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
THTE_RS11835	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
THTE_RS11875	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
THTE_RS11910	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
THTE_RS11915	COG0504	CTP synthase activity
THTE_RS11935	COG0673	inositol 2-dehydrogenase activity
THTE_RS11940	COG1262	PFAM Formylglycine-generating sulfatase enzyme
THTE_RS11940	COG0515	serine threonine protein kinase
THTE_RS11960	COG0300	oxidoreductase activity
THTE_RS11985	COG0534	Mate efflux family protein
THTE_RS11990	COG3119	arylsulfatase activity
THTE_RS12005	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
THTE_RS12025	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
THTE_RS12075	COG2226	methyltransferase
THTE_RS12080	COG1082	Xylose isomerase domain protein TIM barrel
THTE_RS12085	COG0095	Lipoate-protein ligase
THTE_RS12090	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
THTE_RS12095	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
THTE_RS12100	COG0509	glycine decarboxylation via glycine cleavage system
THTE_RS12120	COG0348	domain, Protein
THTE_RS12160	COG0352	thiamine-phosphate diphosphorylase activity
THTE_RS12185	COG0134	indole-3-glycerol-phosphate synthase activity
THTE_RS12200	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
THTE_RS12205	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
THTE_RS12245	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
THTE_RS12250	COG0564	pseudouridine synthase activity
THTE_RS12255	COG0443	Heat shock 70 kDa protein
THTE_RS12265	COG0542	response to heat
THTE_RS12270	COG2234	aminopeptidase activity
THTE_RS12275	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
THTE_RS12285	COG1324	tolerance protein
THTE_RS12295	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
THTE_RS12300	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
THTE_RS12305	COG4112	unkown
THTE_RS12310	COG1104	cysteine desulfurase activity
THTE_RS12315	COG2815	serine threonine protein kinase
THTE_RS12315	COG0515	serine threonine protein kinase
THTE_RS12320	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
THTE_RS12335	COG0156	8-amino-7-oxononanoate synthase activity
THTE_RS12350	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
THTE_RS12360	COG0667	Aldo Keto reductase
THTE_RS12395	COG2165	general secretion pathway protein
THTE_RS12400	COG1459	type II secretion system
THTE_RS12405	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
THTE_RS12420	COG1136	(ABC) transporter
THTE_RS12420	COG0577	efflux transmembrane transporter activity
THTE_RS12425	COG1132	(ABC) transporter
THTE_RS12430	COG0275	rRNA processing
THTE_RS12440	COG4656	Part of a membrane complex involved in electron transport
THTE_RS12450	COG4191	Histidine kinase
THTE_RS12465	COG1899	peptidyl-lysine modification to peptidyl-hypusine
THTE_RS12485	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
THTE_RS12490	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
THTE_RS12495	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
THTE_RS12500	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
THTE_RS12515	COG0445	tRNA wobble uridine modification
THTE_RS12530	COG3253	May function as heme-dependent peroxidase
THTE_RS12535	COG0601	transmembrane transport
THTE_RS12540	COG1940	carbohydrate kinase activity
THTE_RS12575	COG1215	transferase activity, transferring glycosyl groups
THTE_RS12590	COG3119	arylsulfatase activity
THTE_RS12595	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
THTE_RS12600	COG3063	Type IV pilus biogenesis stability protein PilW
THTE_RS12655	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
THTE_RS12670	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
THTE_RS12675	COG4591	ABC-type transport system involved in lipoprotein release permease component
THTE_RS12680	COG1136	(ABC) transporter
THTE_RS12685	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
THTE_RS12765	COG3437	response regulator, receiver
THTE_RS12775	COG0438	transferase activity, transferring glycosyl groups
THTE_RS12780	COG1446	asparaginase
THTE_RS12785	COG0784	Response regulator, receiver
THTE_RS12785	COG2205	protein histidine kinase activity
THTE_RS12785	COG5002	protein histidine kinase activity
THTE_RS12795	COG4771	TonB-dependent receptor
THTE_RS12805	COG0154	amidase activity
THTE_RS12810	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
THTE_RS12820	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
THTE_RS12850	COG0515	serine threonine protein kinase
THTE_RS12850	COG2815	serine threonine protein kinase
THTE_RS12865	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
THTE_RS12895	COG0142	geranyltranstransferase activity
THTE_RS12905	COG0544	peptidyl-prolyl cis-trans isomerase activity
THTE_RS12915	COG0515	serine threonine protein kinase
THTE_RS12915	COG2815	serine threonine protein kinase
THTE_RS12945	COG0657	acetylesterase activity
THTE_RS12950	COG3693	PFAM glycoside hydrolase, family 10
THTE_RS12950	COG3509	depolymerase
THTE_RS12965	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
THTE_RS12975	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
THTE_RS12990	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
THTE_RS12995	COG0840	transmembrane signaling receptor activity
THTE_RS13050	COG1192	Involved in chromosome partitioning
THTE_RS13065	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
THTE_RS13070	COG0038	chloride channel
THTE_RS13110	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
THTE_RS13115	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
THTE_RS13140	COG0859	PFAM glycosyl transferase family 9
THTE_RS13155	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
THTE_RS13165	COG0456	acetyltransferase
THTE_RS13175	COG1120	ATPase activity
THTE_RS13185	COG0667	Aldo Keto reductase
THTE_RS13200	COG0126	phosphoglycerate kinase activity
THTE_RS13205	COG2373	Large extracellular alpha-helical protein
THTE_RS13215	COG1216	Glycosyl transferase, family 2
THTE_RS13225	COG0673	inositol 2-dehydrogenase activity
THTE_RS13245	COG1408	metallophosphoesterase
THTE_RS13250	COG2363	Small membrane protein
THTE_RS13265	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
THTE_RS13295	COG1078	dGTPase activity
THTE_RS13310	COG0811	peptide transport
THTE_RS13325	COG4974	Belongs to the 'phage' integrase family
THTE_RS13340	COG2096	Adenosyltransferase
THTE_RS13345	COG0004	ammonium transporteR
THTE_RS13350	COG0347	Belongs to the P(II) protein family
THTE_RS13355	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
THTE_RS13370	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
THTE_RS13375	COG0525	valine-tRNA ligase activity
THTE_RS13380	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
THTE_RS13420	COG1858	cytochrome C peroxidase
THTE_RS13430	COG3250	beta-galactosidase activity
THTE_RS13445	COG1058	Belongs to the CinA family
THTE_RS13445	COG1546	Belongs to the CinA family
THTE_RS13570	COG3209	COG3209 Rhs family protein
THTE_RS13630	COG0019	diaminopimelate decarboxylase activity
THTE_RS13645	COG0469	pyruvate kinase activity
THTE_RS13650	COG0673	inositol 2-dehydrogenase activity
THTE_RS13655	COG0673	inositol 2-dehydrogenase activity
THTE_RS13665	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
THTE_RS13670	COG0049	tRNA binding
THTE_RS13675	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
THTE_RS13715	COG3119	arylsulfatase activity
THTE_RS13725	COG0347	Belongs to the P(II) protein family
THTE_RS13735	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
THTE_RS13765	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
THTE_RS13770	COG1214	PFAM Peptidase M22, glycoprotease
THTE_RS13795	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
THTE_RS13815	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
THTE_RS13820	COG0081	regulation of translation
THTE_RS13825	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
THTE_RS13830	COG0222	ribosome binding
THTE_RS13835	COG0085	RNA polymerase activity
THTE_RS13840	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
THTE_RS13845	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
THTE_RS13865	COG1073	alpha beta
THTE_RS13870	COG0456	acetyltransferase
THTE_RS13875	COG0667	Aldo Keto reductase
THTE_RS13880	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
THTE_RS13885	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
THTE_RS13890	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
THTE_RS13895	COG1028	Short-chain dehydrogenase reductase Sdr
THTE_RS13900	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
THTE_RS13920	COG0404	The glycine cleavage system catalyzes the degradation of glycine
THTE_RS13925	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
THTE_RS13935	COG0598	Magnesium transport protein CorA
THTE_RS13965	COG2814	Major facilitator Superfamily
THTE_RS13965	COG2814	Major facilitator Superfamily
THTE_RS14005	COG1242	4 iron, 4 sulfur cluster binding
THTE_RS14015	COG1162	GTPase activity
THTE_RS14020	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
THTE_RS14025	COG1028	Short-chain dehydrogenase reductase Sdr
THTE_RS14050	COG0210	DNA helicase
THTE_RS14055	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
THTE_RS14065	COG3119	arylsulfatase activity
THTE_RS14110	COG1904	glucuronate isomerase
THTE_RS14180	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
THTE_RS14185	COG3401	FG-GAP repeat protein
THTE_RS14190	COG1691	(AIR) carboxylase
THTE_RS14195	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
THTE_RS14195	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
THTE_RS14200	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
THTE_RS14205	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
THTE_RS14210	COG0211	Belongs to the bacterial ribosomal protein bL27 family
THTE_RS14220	COG0242	peptide deformylase activity
THTE_RS14265	COG4221	oxidoreductase activity
THTE_RS14270	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
THTE_RS14280	COG0717	Belongs to the dCTP deaminase family
THTE_RS14285	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
THTE_RS14310	COG0305	Participates in initiation and elongation during chromosome replication
THTE_RS14345	COG1560	Kdo2-lipid A biosynthetic process
THTE_RS14370	COG1959	2 iron, 2 sulfur cluster binding
THTE_RS14405	COG1137	ATPase activity
THTE_RS14435	COG1192	Involved in chromosome partitioning
THTE_RS14460	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
THTE_RS14495	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
THTE_RS14500	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
THTE_RS14505	COG3852	Histidine kinase
THTE_RS14525	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
THTE_RS14530	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
THTE_RS14530	COG0574	Belongs to the PEP-utilizing enzyme family
THTE_RS14580	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
THTE_RS14585	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
THTE_RS14590	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
THTE_RS14595	COG4535	Mg2 and Co2 transporter CorC
THTE_RS14610	COG2135	peptidase activity
THTE_RS14620	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
THTE_RS14620	COG0646	methionine synthase
THTE_RS14640	COG1454	alcohol dehydrogenase
THTE_RS14655	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
THTE_RS14665	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
THTE_RS14670	COG4589	Belongs to the CDS family
THTE_RS14675	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
THTE_RS14720	COG0826	peptidase U32
THTE_RS14725	COG3119	arylsulfatase activity
THTE_RS14740	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
THTE_RS14745	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
THTE_RS14755	COG2379	hydroxypyruvate reductase
THTE_RS14765	COG1104	cysteine desulfurase activity
THTE_RS14800	COG0835	chemotaxis
THTE_RS14800	COG0784	Response regulator, receiver
THTE_RS14805	COG2815	serine threonine protein kinase
THTE_RS14805	COG0515	serine threonine protein kinase
THTE_RS14810	COG1136	(ABC) transporter
THTE_RS14825	COG0805	protein transport
THTE_RS14835	COG2084	Dehydrogenase
THTE_RS14845	COG4864	UPF0365 protein
THTE_RS14890	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
THTE_RS14900	COG1082	Xylose isomerase domain protein TIM barrel
THTE_RS14920	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
THTE_RS14925	COG1449	Belongs to the glycosyl hydrolase 57 family
THTE_RS14940	COG1301	dicarboxylic acid transport
THTE_RS14975	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
THTE_RS14985	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
THTE_RS14995	COG2226	methyltransferase
THTE_RS15010	COG0297	glycogen (starch) synthase activity
THTE_RS15025	COG1129	ABC transporter
THTE_RS15040	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
THTE_RS15050	COG0483	inositol monophosphate 1-phosphatase activity
THTE_RS15075	COG0202	RNA polymerase activity
THTE_RS15100	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
THTE_RS15105	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
THTE_RS15110	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
THTE_RS15115	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
THTE_RS15120	COG2848	UPF0210 protein
THTE_RS15150	COG3119	arylsulfatase activity
THTE_RS15155	COG0673	inositol 2-dehydrogenase activity
THTE_RS15180	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
THTE_RS15220	COG1032	radical SAM domain protein
THTE_RS15225	COG0443	Heat shock 70 kDa protein
THTE_RS15235	COG3118	belongs to the thioredoxin family
THTE_RS15240	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
THTE_RS15260	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
THTE_RS15265	COG1053	succinate dehydrogenase
THTE_RS15270	COG2009	succinate dehydrogenase
THTE_RS15275	COG0745	RESPONSE REGULATOR receiver
THTE_RS15345	COG1442	glycosyl transferase family 8
THTE_RS15345	COG1216	Glycosyl transferase, family 2
THTE_RS15350	COG0438	transferase activity, transferring glycosyl groups
THTE_RS15355	COG0463	Glycosyl transferase, family 2
THTE_RS15360	COG0110	maltose O-acetyltransferase activity
THTE_RS15380	COG0438	transferase activity, transferring glycosyl groups
THTE_RS15380	COG0297	glycogen (starch) synthase activity
THTE_RS15390	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
THTE_RS15395	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
THTE_RS15395	COG1796	DNA polymerase
THTE_RS15400	COG0045	succinate-CoA ligase (ADP-forming) activity
THTE_RS15405	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
THTE_RS15410	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
THTE_RS15460	COG0463	Glycosyl transferase, family 2
THTE_RS15475	COG2197	response regulator
THTE_RS15480	COG2204	response regulator
THTE_RS15530	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
THTE_RS15575	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
THTE_RS15580	COG0626	cystathionine gamma-synthase activity
THTE_RS15585	COG0626	cystathionine gamma-synthase activity
THTE_RS15605	COG2211	Major facilitator Superfamily
THTE_RS15620	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
THTE_RS15625	COG0484	heat shock protein binding
THTE_RS15630	COG0459	protein refolding
THTE_RS15635	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
THTE_RS15640	COG0459	protein refolding
THTE_RS15680	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
THTE_RS15685	COG1872	DUF167
THTE_RS15690	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
THTE_RS15730	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
THTE_RS15745	COG0788	formyltetrahydrofolate deformylase activity
THTE_RS15765	COG1063	alcohol dehydrogenase
THTE_RS15780	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
THTE_RS15785	COG1562	ergosterol biosynthetic process
THTE_RS15795	COG1233	COG1233 Phytoene dehydrogenase and related
THTE_RS15810	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
THTE_RS15820	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
THTE_RS15825	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
THTE_RS15855	COG4964	Belongs to the GSP D family
THTE_RS15890	COG1121	(ABC) transporter
THTE_RS15895	COG1108	ABC-type Mn2 Zn2 transport systems permease components
THTE_RS15905	COG0359	binds to the 23S rRNA
THTE_RS15910	COG0629	single-stranded DNA binding
THTE_RS15915	COG0360	Binds together with S18 to 16S ribosomal RNA
THTE_RS15920	COG0193	aminoacyl-tRNA hydrolase activity
THTE_RS15925	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
THTE_RS15935	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
THTE_RS15990	COG1480	7TM receptor with intracellular HD hydrolase
THTE_RS15995	COG1702	phosphate starvation-inducible protein PhoH
THTE_RS16010	COG0473	3-isopropylmalate dehydrogenase activity
THTE_RS16020	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
THTE_RS16030	COG2204	response regulator
THTE_RS16045	COG2249	NAD(P)H dehydrogenase (quinone) activity
THTE_RS16055	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
THTE_RS16075	COG0612	Peptidase, M16
THTE_RS16080	COG0612	Peptidase, M16
THTE_RS16085	COG0571	ribonuclease III activity
THTE_RS16090	COG0482	sulfurtransferase activity
THTE_RS16105	COG0674	pyruvate-flavodoxin oxidoreductase activity
THTE_RS16105	COG1013	pyruvate-flavodoxin oxidoreductase activity
THTE_RS16105	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
THTE_RS16105	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
THTE_RS16115	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
THTE_RS16175	COG3209	COG3209 Rhs family protein
THTE_RS16185	COG3209	COG3209 Rhs family protein
THTE_RS16195	COG3209	COG3209 Rhs family protein
THTE_RS16205	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
THTE_RS16245	COG1968	undecaprenyl-diphosphatase activity
THTE_RS16290	COG0673	inositol 2-dehydrogenase activity
THTE_RS16305	COG1530	ribonuclease E activity
THTE_RS16375	COG0714	Associated with various cellular activities
THTE_RS16415	COG0463	Glycosyl transferase, family 2
THTE_RS16440	COG0457	Tetratricopeptide repeat
THTE_RS16455	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
THTE_RS16460	COG2189	Belongs to the N(4) N(6)-methyltransferase family
THTE_RS16475	COG1309	transcriptional regulator
THTE_RS16515	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
THTE_RS16525	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
THTE_RS16570	COG1086	Polysaccharide biosynthesis protein
THTE_RS16605	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
THTE_RS16620	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
THTE_RS16625	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
THTE_RS16650	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
THTE_RS16655	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
THTE_RS16660	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
THTE_RS16665	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
THTE_RS16670	COG0686	Belongs to the AlaDH PNT family
THTE_RS16680	COG0505	Belongs to the CarA family
THTE_RS16705	COG4964	Belongs to the GSP D family
THTE_RS16720	COG3119	arylsulfatase activity
THTE_RS16730	COG0436	Aminotransferase
THTE_RS16740	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
THTE_RS16755	COG1331	Highly conserved protein containing a thioredoxin domain
THTE_RS16785	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
THTE_RS16815	COG1160	GTP binding
THTE_RS16825	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
THTE_RS16885	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
THTE_RS16910	COG0436	Aminotransferase
THTE_RS16935	COG1774	PSP1 C-terminal conserved region
THTE_RS16940	COG2801	Transposase and inactivated derivatives
THTE_RS16955	COG0445	tRNA wobble uridine modification
THTE_RS16975	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
THTE_RS16975	COG1754	DNA topoisomerase type I activity
THTE_RS16990	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
THTE_RS16995	COG1858	cytochrome C peroxidase
THTE_RS17000	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
THTE_RS17010	COG0643	Histidine kinase
THTE_RS17010	COG2198	Histidine kinase
THTE_RS17040	COG0156	8-amino-7-oxononanoate synthase activity
THTE_RS17045	COG2151	metal-sulfur cluster biosynthetic enzyme
THTE_RS17055	COG0719	Fe-S assembly protein
THTE_RS17060	COG0719	Fe-S assembly protein
THTE_RS17065	COG0396	ATPase activity
THTE_RS17070	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
THTE_RS17080	COG0733	neurotransmitter:sodium symporter activity
THTE_RS17090	COG2048	Heterodisulfide reductase, subunit B
THTE_RS17095	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
THTE_RS17105	COG1941	NADH ubiquinone oxidoreductase 20 kDa subunit
THTE_RS17110	COG3259	Nickel-dependent hydrogenase
THTE_RS17130	COG1203	CRISPR-associated helicase, Cas3
THTE_RS17140	COG1518	maintenance of DNA repeat elements
THTE_RS17145	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
THTE_RS17155	COG2154	pterin-4-alpha-carbinolamine dehydratase
THTE_RS17170	COG0828	Belongs to the bacterial ribosomal protein bS21 family
THTE_RS17250	COG1706	bacterial-type flagellum-dependent cell motility
THTE_RS17255	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
THTE_RS17265	COG4786	Flagellar basal body rod
THTE_RS17270	COG4786	Flagellar basal body rod
THTE_RS17280	COG0181	hydroxymethylbilane synthase activity
THTE_RS17290	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
THTE_RS17290	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
THTE_RS17290	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
THTE_RS17295	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
THTE_RS17300	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
THTE_RS17305	COG0667	Aldo Keto reductase
THTE_RS17315	COG0811	peptide transport
THTE_RS17320	COG0848	biopolymer transport protein
THTE_RS17335	COG2706	6-phosphogluconolactonase activity
THTE_RS17355	COG0698	ribose 5-phosphate isomerase
THTE_RS17365	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
THTE_RS17390	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
THTE_RS17415	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
THTE_RS17420	COG3940	Belongs to the glycosyl hydrolase 43 family
THTE_RS17430	COG0352	thiamine-phosphate diphosphorylase activity
THTE_RS17430	COG0351	phosphomethylpyrimidine kinase
THTE_RS17440	COG0438	transferase activity, transferring glycosyl groups
THTE_RS17460	COG1053	succinate dehydrogenase
THTE_RS17470	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
THTE_RS17480	COG0227	Belongs to the bacterial ribosomal protein bL28 family
THTE_RS17485	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
THTE_RS17570	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
THTE_RS17575	COG0632	four-way junction helicase activity
THTE_RS17590	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
THTE_RS17595	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
THTE_RS17605	COG0113	porphobilinogen synthase activity
THTE_RS17615	COG1881	PFAM PEBP family protein
THTE_RS17625	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
THTE_RS17630	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
THTE_RS17635	COG0602	queuosine metabolic process
THTE_RS17655	COG2088	sporulation resulting in formation of a cellular spore
THTE_RS17660	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
THTE_RS17685	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
THTE_RS17710	COG0012	GTP binding
THTE_RS17730	COG0673	inositol 2-dehydrogenase activity