locus-tag	class	description
TRD_RS00010	COG0470	DNA polymerase III
TRD_RS00030	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
TRD_RS00035	COG2205	protein histidine kinase activity
TRD_RS00045	COG0284	orotidine-5'-phosphate decarboxylase activity
TRD_RS00050	COG0693	protein deglycase activity
TRD_RS00060	COG1131	(ABC) transporter
TRD_RS00065	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
TRD_RS00095	COG1203	CRISPR-associated helicase, Cas3
TRD_RS00105	COG1518	maintenance of DNA repeat elements
TRD_RS00110	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
TRD_RS00115	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
TRD_RS00120	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
TRD_RS00125	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
TRD_RS00130	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
TRD_RS00160	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
TRD_RS00185	COG1960	acyl-CoA dehydrogenase activity
TRD_RS00190	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
TRD_RS00195	COG1024	Enoyl-CoA hydratase
TRD_RS00200	COG2086	electron transfer activity
TRD_RS00205	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
TRD_RS00210	COG0644	oxidoreductase
TRD_RS00220	COG0456	acetyltransferase
TRD_RS00255	COG2001	Belongs to the MraZ family
TRD_RS00260	COG0275	rRNA processing
TRD_RS00270	COG0768	penicillin binding
TRD_RS00275	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
TRD_RS00280	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
TRD_RS00285	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
TRD_RS00290	COG0772	Belongs to the SEDS family
TRD_RS00295	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
TRD_RS00300	COG0812	UDP-N-acetylmuramate dehydrogenase activity
TRD_RS00305	COG1181	Belongs to the D-alanine--D-alanine ligase family
TRD_RS00310	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
TRD_RS00315	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
TRD_RS00320	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
TRD_RS00330	COG3118	belongs to the thioredoxin family
TRD_RS00345	COG1574	metal-dependent hydrolase with the TIM-barrel fold
TRD_RS00350	COG0640	Transcriptional regulator
TRD_RS00370	COG0531	amino acid
TRD_RS00390	COG0366	Alpha amylase catalytic
TRD_RS00400	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
TRD_RS00410	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
TRD_RS00410	COG0426	domain, Protein
TRD_RS00415	COG0438	transferase activity, transferring glycosyl groups
TRD_RS00420	COG0438	transferase activity, transferring glycosyl groups
TRD_RS00425	COG0227	Belongs to the bacterial ribosomal protein bL28 family
TRD_RS00430	COG2890	protein-(glutamine-N5) methyltransferase activity
TRD_RS00435	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
TRD_RS00460	COG0742	ribosomal rna small subunit methyltransferase
TRD_RS00465	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
TRD_RS00480	COG0840	transmembrane signaling receptor activity
TRD_RS00495	COG0512	Glutamine amidotransferase of anthranilate synthase
TRD_RS00500	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
TRD_RS00505	COG0134	indole-3-glycerol-phosphate synthase activity
TRD_RS00510	COG0135	phosphoribosylanthranilate isomerase activity
TRD_RS00515	COG0133	tryptophan synthase activity
TRD_RS00520	COG0159	tryptophan synthase activity
TRD_RS00530	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
TRD_RS00535	COG0140	phosphoribosyl-ATP diphosphatase activity
TRD_RS00535	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
TRD_RS00540	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
TRD_RS00545	COG1837	Belongs to the UPF0109 family
TRD_RS00550	COG0228	four-way junction DNA binding
TRD_RS00555	COG0393	Putative heavy-metal-binding
TRD_RS00565	COG0045	succinate-CoA ligase (ADP-forming) activity
TRD_RS00575	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
TRD_RS00580	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
TRD_RS00585	COG4638	Rieske (2fe-2S)
TRD_RS00590	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
TRD_RS00610	COG0582	viral genome integration into host DNA
TRD_RS00635	COG1850	ribulose-bisphosphate carboxylase activity
TRD_RS00640	COG0673	inositol 2-dehydrogenase activity
TRD_RS00690	COG0509	glycine decarboxylation via glycine cleavage system
TRD_RS00695	COG0509	glycine decarboxylation via glycine cleavage system
TRD_RS00710	COG0247	lactate metabolic process
TRD_RS00710	COG2181	nitrate reductase activity
TRD_RS00715	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
TRD_RS00720	COG2086	electron transfer activity
TRD_RS00725	COG2181	nitrate reductase activity
TRD_RS00725	COG0247	lactate metabolic process
TRD_RS00760	COG0509	glycine decarboxylation via glycine cleavage system
TRD_RS00770	COG2210	Belongs to the sulfur carrier protein TusA family
TRD_RS00775	COG0425	Belongs to the sulfur carrier protein TusA family
TRD_RS00790	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
TRD_RS00795	COG3872	metal-dependent enzyme
TRD_RS00800	COG0165	Argininosuccinate lyase
TRD_RS00805	COG2153	protein acetylation
TRD_RS00810	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
TRD_RS00815	COG0321	lipoyl(octanoyl) transferase activity
TRD_RS00830	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
TRD_RS00840	COG0802	atpase or kinase
TRD_RS00845	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
TRD_RS00855	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
TRD_RS00860	COG0483	inositol monophosphate 1-phosphatase activity
TRD_RS00865	COG0123	including yeast histone deacetylase and acetoin utilization protein
TRD_RS00870	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
TRD_RS00875	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
TRD_RS00885	COG0107	imidazoleglycerol-phosphate synthase activity
TRD_RS00890	COG0791	NLP P60 protein
TRD_RS00900	COG1131	(ABC) transporter
TRD_RS00905	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
TRD_RS00910	COG3870	Protein conserved in bacteria
TRD_RS00915	COG3845	ABC transporter
TRD_RS00950	COG1381	Involved in DNA repair and RecF pathway recombination
TRD_RS00955	COG0800	Aldolase
TRD_RS00960	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
TRD_RS00970	COG3870	Protein conserved in bacteria
TRD_RS00975	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
TRD_RS00980	COG3854	ATPases associated with a variety of cellular activities
TRD_RS00990	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
TRD_RS00995	COG1674	ftsk spoiiie
TRD_RS00995	COG4980	gas vesicle protein
TRD_RS01000	COG1573	uracil-dna glycosylase
TRD_RS01010	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
TRD_RS01015	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
TRD_RS01025	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
TRD_RS01030	COG0505	Belongs to the CarA family
TRD_RS01035	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
TRD_RS01040	COG0424	maF-like protein
TRD_RS01045	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
TRD_RS01050	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
TRD_RS01080	COG0577	efflux transmembrane transporter activity
TRD_RS01080	COG1136	(ABC) transporter
TRD_RS01090	COG0336	Belongs to the RNA methyltransferase TrmD family
TRD_RS01115	COG4166	transmembrane transport
TRD_RS01125	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
TRD_RS01130	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
TRD_RS01135	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
TRD_RS01140	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
TRD_RS01145	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
TRD_RS01155	COG1673	EVE domain
TRD_RS01180	COG1028	Short-chain dehydrogenase reductase Sdr
TRD_RS01185	COG0395	ABC-type sugar transport system, permease component
TRD_RS01190	COG1175	transmembrane transport
TRD_RS01200	COG1414	Transcriptional regulator
TRD_RS01225	COG0277	FAD linked oxidase domain protein
TRD_RS01235	COG0247	lactate metabolic process
TRD_RS01245	COG0823	Involved in the tonB-independent uptake of proteins
TRD_RS01245	COG1506	peptidase
TRD_RS01245	COG4946	Tricorn protease homolog
TRD_RS01265	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
TRD_RS01270	COG1363	Peptidase, m42
TRD_RS01280	COG1136	(ABC) transporter
TRD_RS01330	COG0484	heat shock protein binding
TRD_RS01380	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
TRD_RS01385	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
TRD_RS01395	COG1028	Short-chain dehydrogenase reductase Sdr
TRD_RS01420	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
TRD_RS01435	COG0574	Belongs to the PEP-utilizing enzyme family
TRD_RS01435	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
TRD_RS01440	COG0346	lactoylglutathione lyase activity
TRD_RS01475	COG0820	rRNA (adenine-C2-)-methyltransferase activity
TRD_RS01480	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
TRD_RS01495	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
TRD_RS01530	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
TRD_RS01535	COG1053	succinate dehydrogenase
TRD_RS01545	COG2009	succinate dehydrogenase
TRD_RS01555	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
TRD_RS01555	COG1199	ATP-dependent helicase activity
TRD_RS01565	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
TRD_RS01575	COG0596	Alpha beta hydrolase
TRD_RS01585	COG1385	rRNA (uridine-N3-)-methyltransferase activity
TRD_RS01590	COG2264	protein methyltransferase activity
TRD_RS01595	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
TRD_RS01610	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
TRD_RS01625	COG1803	Methylglyoxal synthase
TRD_RS01625	COG1597	lipid kinase activity
TRD_RS01630	COG1426	Protein conserved in bacteria
TRD_RS01640	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TRD_RS01660	COG0405	Gamma-glutamyltransferase
TRD_RS01665	COG0746	molybdenum cofactor guanylyltransferase activity
TRD_RS01675	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
TRD_RS01680	COG0726	polysaccharide deacetylase
TRD_RS01690	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
TRD_RS01700	COG0460	homoserine dehydrogenase
TRD_RS01705	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
TRD_RS01715	COG2409	Drug exporters of the RND superfamily
TRD_RS01740	COG2151	metal-sulfur cluster biosynthetic enzyme
TRD_RS01745	COG0822	iron-sulfur transferase activity
TRD_RS01750	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
TRD_RS01755	COG0719	Fe-S assembly protein
TRD_RS01760	COG0719	Fe-S assembly protein
TRD_RS01765	COG0396	ATPase activity
TRD_RS01770	COG0735	belongs to the Fur family
TRD_RS01790	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
TRD_RS01795	COG1574	metal-dependent hydrolase with the TIM-barrel fold
TRD_RS01810	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
TRD_RS01820	COG4166	transmembrane transport
TRD_RS01825	COG0601	transmembrane transport
TRD_RS01830	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TRD_RS01835	COG0351	phosphomethylpyrimidine kinase
TRD_RS01840	COG2022	thiamine diphosphate biosynthetic process
TRD_RS01845	COG0352	thiamine-phosphate diphosphorylase activity
TRD_RS01850	COG0352	thiamine-phosphate diphosphorylase activity
TRD_RS01855	COG2104	thiamine diphosphate biosynthetic process
TRD_RS01865	COG2076	Multidrug Resistance protein
TRD_RS01870	COG0653	protein targeting
TRD_RS01875	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
TRD_RS01890	COG1999	signal sequence binding
TRD_RS01910	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
TRD_RS01915	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
TRD_RS01925	COG0438	transferase activity, transferring glycosyl groups
TRD_RS01940	COG1921	L-seryl-tRNASec selenium transferase activity
TRD_RS01945	COG0358	DNA primase activity
TRD_RS01950	COG0232	Belongs to the dGTPase family. Type 2 subfamily
TRD_RS01955	COG0404	The glycine cleavage system catalyzes the degradation of glycine
TRD_RS01965	COG0322	excinuclease ABC activity
TRD_RS01970	COG0009	L-threonylcarbamoyladenylate synthase
TRD_RS01975	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
TRD_RS01990	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
TRD_RS01995	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
TRD_RS02000	COG0131	Imidazoleglycerol-phosphate dehydratase
TRD_RS02005	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
TRD_RS02015	COG1187	pseudouridine synthase activity
TRD_RS02020	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
TRD_RS02040	COG0789	Transcriptional regulator
TRD_RS02045	COG0542	response to heat
TRD_RS02060	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
TRD_RS02070	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
TRD_RS02080	COG0438	transferase activity, transferring glycosyl groups
TRD_RS02095	COG2301	Belongs to the HpcH HpaI aldolase family
TRD_RS02105	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
TRD_RS02110	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
TRD_RS02110	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
TRD_RS02115	COG0497	DNA recombination
TRD_RS02120	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
TRD_RS02125	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
TRD_RS02155	COG0437	4 iron, 4 sulfur cluster binding
TRD_RS02160	COG0243	molybdopterin cofactor binding
TRD_RS02195	COG3959	Transketolase, thiamine diphosphate binding domain
TRD_RS02200	COG3958	Transketolase
TRD_RS02205	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
TRD_RS02220	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
TRD_RS02245	COG0793	Belongs to the peptidase S41A family
TRD_RS02255	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
TRD_RS02265	COG1968	undecaprenyl-diphosphatase activity
TRD_RS02270	COG0477	Major facilitator Superfamily
TRD_RS02275	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TRD_RS02285	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
TRD_RS02315	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
TRD_RS02315	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
TRD_RS02325	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
TRD_RS02325	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
TRD_RS02330	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
TRD_RS02355	COG1331	Highly conserved protein containing a thioredoxin domain
TRD_RS02370	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
TRD_RS02390	COG2226	methyltransferase
TRD_RS02410	COG1177	transmembrane transport
TRD_RS02420	COG3842	ATPase activity
TRD_RS02435	COG0489	protein tyrosine kinase activity
TRD_RS02440	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
TRD_RS02455	COG3665	Urea carboxylase-associated protein
TRD_RS02465	COG0832	Belongs to the urease beta subunit family
TRD_RS02465	COG0831	urea catabolic process
TRD_RS02470	COG0831	urea catabolic process
TRD_RS02470	COG0832	Belongs to the urease beta subunit family
TRD_RS02490	COG0828	Belongs to the bacterial ribosomal protein bS21 family
TRD_RS02500	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
TRD_RS02505	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
TRD_RS02515	COG0018	arginyl-trna synthetase
TRD_RS02520	COG1316	TRANSCRIPTIONal
TRD_RS02525	COG0717	Belongs to the dCTP deaminase family
TRD_RS02530	COG2096	Adenosyltransferase
TRD_RS02575	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
TRD_RS02580	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
TRD_RS02595	COG0508	dehydrogenase complex catalyzes the overall conversion of
TRD_RS02600	COG0567	Dehydrogenase, E1 component
TRD_RS02605	COG0644	oxidoreductase
TRD_RS02610	COG2239	Acts as a magnesium transporter
TRD_RS02625	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
TRD_RS02625	COG1796	DNA polymerase
TRD_RS02645	COG1304	FMN binding
TRD_RS02650	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
TRD_RS02675	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
TRD_RS02725	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
TRD_RS02730	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
TRD_RS02735	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
TRD_RS02755	COG1234	tRNA 3'-trailer cleavage
TRD_RS02760	COG0405	Gamma-glutamyltransferase
TRD_RS02780	COG0205	6-phosphofructokinase activity
TRD_RS02785	COG0442	prolyl-tRNA aminoacylation
TRD_RS02805	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
TRD_RS02815	COG1716	ATPase activity
TRD_RS02830	COG0463	Glycosyl transferase, family 2
TRD_RS02835	COG1872	DUF167
TRD_RS02840	COG1606	tRNA processing
TRD_RS02850	COG1185	polyribonucleotide nucleotidyltransferase activity
TRD_RS02855	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
TRD_RS02860	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
TRD_RS02865	COG0440	acetolactate synthase activity
TRD_RS02870	COG0028	Belongs to the TPP enzyme family
TRD_RS02890	COG0631	protein serine/threonine phosphatase activity
TRD_RS02900	COG0632	four-way junction helicase activity
TRD_RS02905	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
TRD_RS02915	COG0124	histidyl-tRNA synthetase
TRD_RS02920	COG0072	phenylalanine-tRNA ligase activity
TRD_RS02920	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TRD_RS02925	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
TRD_RS02930	COG0148	phosphopyruvate hydratase activity
TRD_RS02935	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
TRD_RS02940	COG0129	dihydroxy-acid dehydratase activity
TRD_RS02955	COG0473	3-isopropylmalate dehydrogenase activity
TRD_RS02965	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
TRD_RS02970	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
TRD_RS02975	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
TRD_RS02985	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
TRD_RS03000	COG1260	myo-inositol-1-phosphate synthase
TRD_RS03010	COG0438	transferase activity, transferring glycosyl groups
TRD_RS03015	COG0859	PFAM glycosyl transferase family 9
TRD_RS03020	COG0859	PFAM glycosyl transferase family 9
TRD_RS03025	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
TRD_RS03030	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
TRD_RS03035	COG0484	heat shock protein binding
TRD_RS03050	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
TRD_RS03060	COG1193	negative regulation of DNA recombination
TRD_RS03070	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
TRD_RS03075	COG1596	polysaccharide export
TRD_RS03075	COG1555	photosystem II stabilization
TRD_RS03095	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
TRD_RS03100	COG0267	Belongs to the bacterial ribosomal protein bL33 family
TRD_RS03115	COG0250	Participates in transcription elongation, termination and antitermination
TRD_RS03120	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
TRD_RS03125	COG0081	regulation of translation
TRD_RS03130	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
TRD_RS03155	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
TRD_RS03165	COG1484	DNA-dependent DNA replication
TRD_RS03175	COG0305	Participates in initiation and elongation during chromosome replication
TRD_RS03180	COG0359	binds to the 23S rRNA
TRD_RS03195	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
TRD_RS03210	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
TRD_RS03210	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
TRD_RS03215	COG0714	Associated with various cellular activities
TRD_RS03225	COG1305	Transglutaminase-like
TRD_RS03235	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
TRD_RS03255	COG2010	Cytochrome c
TRD_RS03255	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
TRD_RS03265	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TRD_RS03270	COG0183	Belongs to the thiolase family
TRD_RS03275	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
TRD_RS03280	COG0592	DNA-directed DNA polymerase activity
TRD_RS03290	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
TRD_RS03295	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
TRD_RS03300	COG2255	four-way junction helicase activity
TRD_RS03305	COG2835	tetraacyldisaccharide 4'-kinase activity
TRD_RS03345	COG3870	Protein conserved in bacteria
TRD_RS03355	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
TRD_RS03375	COG0189	ligase activity
TRD_RS03375	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
TRD_RS03385	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
TRD_RS03390	COG0084	hydrolase, TatD family'
TRD_RS03395	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
TRD_RS03400	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
TRD_RS03405	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
TRD_RS03410	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
TRD_RS03415	COG0047	phosphoribosylformylglycinamidine synthase activity
TRD_RS03420	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
TRD_RS03425	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
TRD_RS03430	COG0404	The glycine cleavage system catalyzes the degradation of glycine
TRD_RS03440	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
TRD_RS03445	COG1160	GTP binding
TRD_RS03450	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
TRD_RS03470	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
TRD_RS03475	COG0501	Belongs to the peptidase M48B family
TRD_RS03515	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
TRD_RS03520	COG0196	riboflavin kinase activity
TRD_RS03525	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
TRD_RS03535	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
TRD_RS03540	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
TRD_RS03545	COG2740	Nucleic-acid-binding protein implicated in transcription termination
TRD_RS03550	COG0195	Participates in both transcription termination and antitermination
TRD_RS03555	COG0391	Required for morphogenesis under gluconeogenic growth conditions
TRD_RS03565	COG0126	phosphoglycerate kinase activity
TRD_RS03570	COG0149	triose-phosphate isomerase activity
TRD_RS03585	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
TRD_RS03605	COG0681	Belongs to the peptidase S26 family
TRD_RS03650	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
TRD_RS03660	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
TRD_RS03665	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
TRD_RS03670	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
TRD_RS03675	COG1691	(AIR) carboxylase
TRD_RS03685	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
TRD_RS03685	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
TRD_RS03695	COG0193	aminoacyl-tRNA hydrolase activity
TRD_RS03705	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
TRD_RS03715	COG0343	queuine tRNA-ribosyltransferase activity
TRD_RS03720	COG1254	Belongs to the acylphosphatase family
TRD_RS03725	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
TRD_RS03730	COG0736	holo-[acyl-carrier-protein] synthase activity
TRD_RS03735	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
TRD_RS03735	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
TRD_RS03740	COG0516	GMP reductase activity
TRD_RS03740	COG0517	IMP dehydrogenase activity
TRD_RS03750	COG1234	tRNA 3'-trailer cleavage
TRD_RS03755	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
TRD_RS03760	COG1496	oxidoreductase activity
TRD_RS03770	COG1515	deoxyribonuclease V activity
TRD_RS03775	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
TRD_RS03790	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
TRD_RS03795	COG0291	Belongs to the bacterial ribosomal protein bL35 family
TRD_RS03800	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
TRD_RS03805	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
TRD_RS03810	COG0776	regulation of translation
TRD_RS03815	COG0187	DNA topoisomerase II activity
TRD_RS03830	COG0768	penicillin binding
TRD_RS03840	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
TRD_RS03855	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
TRD_RS03895	COG0268	Binds directly to 16S ribosomal RNA
TRD_RS03900	COG0728	peptidoglycan biosynthetic process
TRD_RS03905	COG0481	GTPase activity
TRD_RS03910	COG3956	TIGRFAM MazG family protein
TRD_RS03915	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
TRD_RS03920	COG3546	catalase activity
TRD_RS03955	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
TRD_RS03965	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
TRD_RS03970	COG1100	Small GTP-binding protein
TRD_RS03975	COG0248	Ppx GppA phosphatase
TRD_RS03980	COG0138	bifunctional purine biosynthesis protein purh
TRD_RS04000	COG2720	vancomycin resistance protein
TRD_RS04005	COG0251	oxidation-reduction process
TRD_RS04015	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
TRD_RS04020	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
TRD_RS04025	COG0628	permease
TRD_RS04030	COG1177	transmembrane transport
TRD_RS04035	COG1176	ABC-type spermidine putrescine transport system, permease component I
TRD_RS04045	COG1473	amidohydrolase
TRD_RS04055	COG3842	ATPase activity
TRD_RS04060	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
TRD_RS04060	COG0825	malonyl-CoA metabolic process
TRD_RS04080	COG0579	oxidoreductase
TRD_RS04085	COG0517	IMP dehydrogenase activity
TRD_RS04085	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
TRD_RS04085	COG0617	tRNA 3'-terminal CCA addition
TRD_RS04130	COG2759	Belongs to the formate--tetrahydrofolate ligase family
TRD_RS04135	COG0404	The glycine cleavage system catalyzes the degradation of glycine
TRD_RS04150	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
TRD_RS04190	COG1312	Catalyzes the dehydration of D-mannonate
TRD_RS04200	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
TRD_RS04215	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
TRD_RS04220	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
TRD_RS04235	COG0039	L-malate dehydrogenase activity
TRD_RS04240	COG0303	'Molybdopterin
TRD_RS04250	COG1940	carbohydrate kinase activity
TRD_RS04275	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
TRD_RS04280	COG0823	Involved in the tonB-independent uptake of proteins
TRD_RS04305	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
TRD_RS04315	COG0799	negative regulation of ribosome biogenesis
TRD_RS04320	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
TRD_RS04325	COG0438	transferase activity, transferring glycosyl groups
TRD_RS04355	COG1234	tRNA 3'-trailer cleavage
TRD_RS04360	COG3191	aminopeptidase activity
TRD_RS04365	COG1082	Xylose isomerase domain protein TIM barrel
TRD_RS04370	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
TRD_RS04375	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
TRD_RS04380	COG0101	tRNA pseudouridine synthase activity
TRD_RS04385	COG0203	ribosomal protein L17
TRD_RS04390	COG0202	RNA polymerase activity
TRD_RS04395	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
TRD_RS04400	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
TRD_RS04405	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
TRD_RS04410	COG0257	Belongs to the bacterial ribosomal protein bL36 family
TRD_RS04415	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
TRD_RS04425	COG0563	adenylate kinase activity
TRD_RS04435	COG0200	Binds to the 23S rRNA
TRD_RS04440	COG1841	ribosomal large subunit assembly
TRD_RS04445	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
TRD_RS04450	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
TRD_RS04455	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
TRD_RS04460	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
TRD_RS04465	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
TRD_RS04470	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
TRD_RS04475	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
TRD_RS04485	COG0255	Belongs to the universal ribosomal protein uL29 family
TRD_RS04490	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
TRD_RS04495	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
TRD_RS04500	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
TRD_RS04505	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
TRD_RS04510	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
TRD_RS04515	COG0089	rRNA binding
TRD_RS04520	COG0088	Forms part of the polypeptide exit tunnel
TRD_RS04525	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
TRD_RS04530	COG0051	transcription antitermination factor activity, RNA binding
TRD_RS04535	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
TRD_RS04545	COG0049	tRNA binding
TRD_RS04550	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
TRD_RS04555	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
TRD_RS04560	COG0085	RNA polymerase activity
TRD_RS04590	COG0052	Belongs to the universal ribosomal protein uS2 family
TRD_RS04595	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
TRD_RS04600	COG0528	UMP kinase activity
TRD_RS04615	COG4589	Belongs to the CDS family
TRD_RS04620	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
TRD_RS04625	COG1040	competence protein
TRD_RS04665	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
TRD_RS04665	COG0392	lysyltransferase activity
TRD_RS04700	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
TRD_RS04705	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
TRD_RS04745	COG2379	hydroxypyruvate reductase
TRD_RS04750	COG0564	pseudouridine synthase activity
TRD_RS04755	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
TRD_RS04760	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
TRD_RS04765	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
TRD_RS04770	COG0542	response to heat
TRD_RS04775	COG0539	negative regulation of cytoplasmic translation
TRD_RS04800	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
TRD_RS04805	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
TRD_RS04810	COG0124	histidyl-tRNA synthetase
TRD_RS04815	COG0521	Mo-molybdopterin cofactor biosynthetic process
TRD_RS04820	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
TRD_RS04825	COG0792	nuclease activity
TRD_RS04830	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
TRD_RS04835	COG0335	large ribosomal subunit rRNA binding
TRD_RS04840	COG0646	methionine synthase
TRD_RS04840	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
TRD_RS04860	COG1475	DNA binding
TRD_RS04865	COG0423	glycine-tRNA ligase activity
TRD_RS04870	COG4974	Belongs to the 'phage' integrase family
TRD_RS04875	COG0686	Belongs to the AlaDH PNT family
TRD_RS04880	COG0750	zinc metalloprotease
TRD_RS04885	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
TRD_RS04895	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
TRD_RS04900	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
TRD_RS04905	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
TRD_RS04910	COG1363	Peptidase, m42
TRD_RS04915	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
TRD_RS04930	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
TRD_RS04940	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
TRD_RS04950	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
TRD_RS04955	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
TRD_RS04975	COG1846	Transcriptional regulator
TRD_RS04985	COG0482	sulfurtransferase activity
TRD_RS04990	COG0315	cyclic pyranopterin monophosphate synthase activity
TRD_RS05005	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
TRD_RS05010	COG0442	prolyl-tRNA aminoacylation
TRD_RS05020	COG1847	R3H domain protein
TRD_RS05025	COG0706	membrane insertase activity
TRD_RS05030	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
TRD_RS05035	COG0594	ribonuclease P activity
TRD_RS05045	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
TRD_RS05070	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
TRD_RS05085	COG0205	6-phosphofructokinase activity
TRD_RS05125	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
TRD_RS05130	COG0070	glutamate synthase
TRD_RS05130	COG0069	glutamate synthase activity
TRD_RS05130	COG0067	glutamate synthase
TRD_RS05135	COG0347	Belongs to the P(II) protein family
TRD_RS05140	COG0004	ammonium transporteR
TRD_RS05165	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
TRD_RS05185	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TRD_RS05190	COG0697	spore germination
TRD_RS05195	COG2366	antibiotic biosynthetic process
TRD_RS05210	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
TRD_RS05215	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
TRD_RS05220	COG0113	porphobilinogen synthase activity
TRD_RS05235	COG0302	gtp cyclohydrolase
TRD_RS05240	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
TRD_RS05240	COG1213	nucleotidyl transferase
TRD_RS05255	COG0513	Belongs to the DEAD box helicase family
TRD_RS05260	COG0217	transcriptional regulatory protein
TRD_RS05270	COG1921	L-seryl-tRNASec selenium transferase activity
TRD_RS05275	COG3842	ATPase activity
TRD_RS05280	COG0395	ABC-type sugar transport system, permease component
TRD_RS05285	COG1175	transmembrane transport
TRD_RS05295	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TRD_RS05305	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
TRD_RS05310	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
TRD_RS05315	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
TRD_RS05325	COG0363	glucosamine-6-phosphate deaminase activity
TRD_RS05335	COG2322	membrane
TRD_RS05345	COG1131	(ABC) transporter
TRD_RS05350	COG0842	Transport permease protein
TRD_RS05380	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
TRD_RS05400	COG1562	ergosterol biosynthetic process
TRD_RS05420	COG1233	COG1233 Phytoene dehydrogenase and related
TRD_RS05425	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
TRD_RS05430	COG0277	FAD linked oxidase domain protein
TRD_RS05430	COG0247	lactate metabolic process
TRD_RS05440	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
TRD_RS05450	COG0477	Major facilitator Superfamily
TRD_RS05460	COG2897	thiosulfate sulfurtransferase activity
TRD_RS05465	COG0822	iron-sulfur transferase activity
TRD_RS05480	COG0613	PHP domain protein
TRD_RS05485	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
TRD_RS05515	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
TRD_RS05520	COG0518	GMP synthase (glutamine-hydrolyzing) activity
TRD_RS05520	COG0519	Catalyzes the synthesis of GMP from XMP
TRD_RS05525	COG0151	Belongs to the GarS family
TRD_RS05530	COG2197	response regulator
TRD_RS05535	COG0494	nUDIX hydrolase
TRD_RS05555	COG0789	Transcriptional regulator
TRD_RS05560	COG0434	BtpA family
TRD_RS05565	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
TRD_RS05565	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
TRD_RS05590	COG2738	Putative neutral zinc metallopeptidase
TRD_RS05600	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
TRD_RS05605	COG0740	serine-type endopeptidase activity
TRD_RS05610	COG0544	peptidyl-prolyl cis-trans isomerase activity
TRD_RS05655	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
TRD_RS05655	COG3608	succinylglutamate desuccinylase aspartoacylase
TRD_RS05660	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
TRD_RS05665	COG0494	nUDIX hydrolase
TRD_RS05680	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
TRD_RS05690	COG1131	(ABC) transporter
TRD_RS05700	COG3088	subunit of a heme lyase
TRD_RS05710	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
TRD_RS05720	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
TRD_RS05725	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
TRD_RS05730	COG0355	proton-transporting ATP synthase activity, rotational mechanism
TRD_RS05735	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
TRD_RS05740	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
TRD_RS05745	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
TRD_RS05750	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
TRD_RS05755	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
TRD_RS05770	COG0504	CTP synthase activity
TRD_RS05775	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
TRD_RS05780	COG2137	regulation of response to DNA damage stimulus
TRD_RS05790	COG0495	leucyl-tRNA aminoacylation
TRD_RS05800	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TRD_RS05830	COG0629	single-stranded DNA binding
TRD_RS05835	COG0360	Binds together with S18 to 16S ribosomal RNA
TRD_RS05845	COG0083	homoserine kinase activity
TRD_RS05850	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
TRD_RS05855	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TRD_RS05860	COG0601	transmembrane transport
TRD_RS05880	COG0297	glycogen (starch) synthase activity
TRD_RS05885	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
TRD_RS05890	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
TRD_RS05895	COG0825	malonyl-CoA metabolic process
TRD_RS05900	COG0071	Belongs to the small heat shock protein (HSP20) family
TRD_RS05910	COG0540	Belongs to the ATCase OTCase family
TRD_RS05915	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
TRD_RS05920	COG0419	ATPase involved in DNA repair
TRD_RS05930	COG0330	HflC and HflK could
TRD_RS05935	COG0616	signal peptide processing
TRD_RS05940	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
TRD_RS05955	COG0745	RESPONSE REGULATOR receiver
TRD_RS05970	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
TRD_RS05975	COG0357	Ribosomal RNA small subunit methyltransferase G
TRD_RS05990	COG0601	transmembrane transport
TRD_RS05995	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TRD_RS06000	COG0747	negative chemotaxis
TRD_RS06005	COG2235	arginine
TRD_RS06015	COG0647	UMP catabolic process
TRD_RS06020	COG0463	Glycosyl transferase, family 2
TRD_RS06035	COG1546	Belongs to the CinA family
TRD_RS06035	COG1058	Belongs to the CinA family
TRD_RS06045	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
TRD_RS06050	COG1480	7TM receptor with intracellular HD hydrolase
TRD_RS06055	COG1610	YqeY-like protein
TRD_RS06070	COG2226	methyltransferase
TRD_RS06095	COG0459	protein refolding
TRD_RS06100	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
TRD_RS06105	COG0436	Aminotransferase
TRD_RS06125	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
TRD_RS06140	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
TRD_RS06150	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
TRD_RS06155	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
TRD_RS06160	COG2815	serine threonine protein kinase
TRD_RS06160	COG0515	serine threonine protein kinase
TRD_RS06190	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
TRD_RS06205	COG1846	Transcriptional regulator
TRD_RS06215	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
TRD_RS06220	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
TRD_RS06225	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
TRD_RS06245	COG4974	Belongs to the 'phage' integrase family
TRD_RS06250	COG0405	Gamma-glutamyltransferase
TRD_RS06255	COG0730	response to heat
TRD_RS06270	COG0730	response to heat
TRD_RS06295	COG1960	acyl-CoA dehydrogenase activity
TRD_RS06310	COG4948	Mandelate Racemase Muconate Lactonizing
TRD_RS06355	COG2848	UPF0210 protein
TRD_RS06365	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
TRD_RS06390	COG2353	YceI-like domain
TRD_RS06395	COG1733	regulation of RNA biosynthetic process
TRD_RS06400	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
TRD_RS06410	COG1804	L-carnitine dehydratase bile acid-inducible protein F
TRD_RS06425	COG0321	lipoyl(octanoyl) transferase activity
TRD_RS06425	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
TRD_RS06440	COG0415	Belongs to the DNA photolyase family
TRD_RS06455	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
TRD_RS06470	COG1993	acr, cog1993
TRD_RS06475	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
TRD_RS06480	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
TRD_RS06490	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
TRD_RS06495	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
TRD_RS06500	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
TRD_RS06525	COG1942	4-Oxalocrotonate Tautomerase
TRD_RS06540	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
TRD_RS06545	COG4569	acetaldehyde dehydrogenase (acetylating) activity
TRD_RS06550	COG1414	Transcriptional regulator
TRD_RS06570	COG0559	Belongs to the binding-protein-dependent transport system permease family
TRD_RS06610	COG0410	ABC transporter
TRD_RS06625	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
TRD_RS06625	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
TRD_RS06645	COG2217	Heavy metal translocating P-type atpase
TRD_RS06650	COG1937	Protein conserved in bacteria
TRD_RS06665	COG2200	EAL domain
TRD_RS06670	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
TRD_RS06685	COG0254	rRNA binding
TRD_RS06690	COG0211	Belongs to the bacterial ribosomal protein bL27 family
TRD_RS06695	COG0261	This protein binds to 23S rRNA in the presence of protein L20
TRD_RS06710	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
TRD_RS06735	COG0772	Belongs to the SEDS family
TRD_RS06740	COG0635	Involved in the biosynthesis of porphyrin-containing compound
TRD_RS06745	COG1192	Involved in chromosome partitioning
TRD_RS06750	COG0516	GMP reductase activity
TRD_RS06750	COG0517	IMP dehydrogenase activity
TRD_RS06810	COG0484	heat shock protein binding
TRD_RS06825	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
TRD_RS06830	COG2195	Cleaves the N-terminal amino acid of tripeptides
TRD_RS06870	COG1012	belongs to the aldehyde dehydrogenase family
TRD_RS06875	COG1027	Aspartate ammonia-lyase
TRD_RS06880	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TRD_RS06890	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
TRD_RS06895	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
TRD_RS06905	COG0569	domain protein
TRD_RS06910	COG0569	domain protein
TRD_RS06950	COG2814	Major facilitator Superfamily
TRD_RS06970	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
TRD_RS06975	COG0022	dehydrogenase e1 component
TRD_RS06985	COG1285	pathogenesis
TRD_RS07020	COG1131	(ABC) transporter
TRD_RS07035	COG0612	Peptidase, M16
TRD_RS07040	COG1546	Belongs to the CinA family
TRD_RS07040	COG1058	Belongs to the CinA family
TRD_RS07060	COG2094	Belongs to the DNA glycosylase MPG family
TRD_RS07065	COG0525	valine-tRNA ligase activity
TRD_RS07080	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
TRD_RS07085	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
TRD_RS07090	COG2226	methyltransferase
TRD_RS07095	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
TRD_RS07100	COG0189	ligase activity
TRD_RS07105	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
TRD_RS07120	COG0747	negative chemotaxis
TRD_RS07125	COG0601	transmembrane transport
TRD_RS07140	COG2217	Heavy metal translocating P-type atpase
TRD_RS07150	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TRD_RS07155	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
TRD_RS07185	COG2814	Major facilitator Superfamily
TRD_RS07225	COG1132	(ABC) transporter
TRD_RS07250	COG0556	nucleotide-excision repair
TRD_RS07260	COG2197	response regulator
TRD_RS07270	COG0316	Belongs to the HesB IscA family
TRD_RS07285	COG0174	glutamine synthetase
TRD_RS07305	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
TRD_RS07305	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
TRD_RS07310	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
TRD_RS07320	COG1077	Cell shape determining protein MreB Mrl
TRD_RS07335	COG1104	cysteine desulfurase activity
TRD_RS07340	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
TRD_RS07350	COG0287	Prephenate dehydrogenase
TRD_RS07365	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
TRD_RS07395	COG1982	Orn Lys Arg decarboxylase major
TRD_RS07475	COG5002	protein histidine kinase activity
TRD_RS07480	COG0745	RESPONSE REGULATOR receiver
TRD_RS07485	COG0758	DNA mediated transformation
TRD_RS07490	COG0662	Cupin 2, conserved barrel domain protein
TRD_RS07490	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
TRD_RS07495	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
TRD_RS07500	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
TRD_RS07505	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
TRD_RS07510	COG1215	transferase activity, transferring glycosyl groups
TRD_RS07515	COG1940	carbohydrate kinase activity
TRD_RS07520	COG4166	transmembrane transport
TRD_RS07525	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
TRD_RS07530	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
TRD_RS07535	COG2515	1-aminocyclopropane-1-carboxylate deaminase
TRD_RS07540	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
TRD_RS07545	COG0242	peptide deformylase activity
TRD_RS07560	COG0805	protein transport
TRD_RS07565	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
TRD_RS07575	COG0439	Biotin carboxylase
TRD_RS07580	COG1028	Short-chain dehydrogenase reductase Sdr
TRD_RS07585	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
TRD_RS07590	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
TRD_RS07595	COG0333	Belongs to the bacterial ribosomal protein bL32 family
TRD_RS07610	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
TRD_RS07615	COG0747	negative chemotaxis
TRD_RS07620	COG0444	Belongs to the ABC transporter superfamily
TRD_RS07625	COG4608	Belongs to the ABC transporter superfamily
TRD_RS07630	COG1994	Peptidase M50
TRD_RS07640	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
TRD_RS07645	COG1104	cysteine desulfurase activity
TRD_RS07650	COG1959	2 iron, 2 sulfur cluster binding
TRD_RS07655	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
TRD_RS07665	COG1420	regulation of RNA biosynthetic process
TRD_RS07670	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
TRD_RS07675	COG0443	Heat shock 70 kDa protein
TRD_RS07750	COG3835	regulator
TRD_RS07780	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
TRD_RS07785	COG1011	Hydrolase
TRD_RS07800	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
TRD_RS07815	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
TRD_RS07825	COG0747	negative chemotaxis
TRD_RS07830	COG0601	transmembrane transport
TRD_RS07835	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TRD_RS07840	COG1175	transmembrane transport
TRD_RS07845	COG0395	ABC-type sugar transport system, permease component
TRD_RS07855	COG0459	protein refolding
TRD_RS07865	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
TRD_RS07875	COG0511	ligase activity, forming carbon-carbon bonds
TRD_RS07880	COG5016	pyruvate
TRD_RS07880	COG0511	ligase activity, forming carbon-carbon bonds
TRD_RS07885	COG0546	phosphoglycolate phosphatase activity
TRD_RS07890	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
TRD_RS07900	COG0657	acetylesterase activity
TRD_RS07915	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
TRD_RS07920	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
TRD_RS07925	COG0066	3-isopropylmalate dehydratase activity
TRD_RS07940	COG1388	LysM domain
TRD_RS07940	COG3858	chitin binding
TRD_RS07945	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
TRD_RS07950	COG0006	proline dipeptidase activity
TRD_RS07955	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
TRD_RS07960	COG0511	ligase activity, forming carbon-carbon bonds
TRD_RS07965	COG1570	exodeoxyribonuclease VII activity
TRD_RS08000	COG0314	molybdopterin synthase activity
TRD_RS08005	COG0303	'Molybdopterin
TRD_RS08010	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
TRD_RS08015	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
TRD_RS08025	COG0019	diaminopimelate decarboxylase activity
TRD_RS08030	COG0488	(ABC) transporter
TRD_RS08035	COG0237	dephospho-CoA kinase activity
TRD_RS08045	COG1994	Peptidase M50
TRD_RS08045	COG0517	IMP dehydrogenase activity
TRD_RS08065	COG1490	D-aminoacyl-tRNA deacylase activity
TRD_RS08070	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
TRD_RS08075	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
TRD_RS08080	COG4956	integral membrane protein (PIN domain superfamily)
TRD_RS08085	COG0613	PHP domain protein
TRD_RS08090	COG2359	stage V sporulation protein S
TRD_RS08110	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
TRD_RS08115	COG0508	dehydrogenase complex catalyzes the overall conversion of
TRD_RS08115	COG0022	dehydrogenase e1 component
TRD_RS08145	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
TRD_RS08155	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
TRD_RS08165	COG3246	L-lysine catabolic process to acetate
TRD_RS08175	COG1196	nuclear chromosome segregation
TRD_RS08180	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
TRD_RS08210	COG2197	response regulator
TRD_RS08220	COG0154	amidase activity
TRD_RS08225	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
TRD_RS08230	COG2723	6-phospho-beta-galactosidase activity
TRD_RS08235	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
TRD_RS08240	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
TRD_RS08245	COG1804	L-carnitine dehydratase bile acid-inducible protein F
TRD_RS08250	COG1024	Enoyl-CoA hydratase
TRD_RS08265	COG2364	Membrane
TRD_RS08275	COG0105	UTP biosynthetic process
TRD_RS08295	COG2217	Heavy metal translocating P-type atpase
TRD_RS08300	COG0297	glycogen (starch) synthase activity
TRD_RS08305	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
TRD_RS08310	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TRD_RS08315	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TRD_RS08330	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
TRD_RS08340	COG0713	ATP synthesis coupled electron transport
TRD_RS08345	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
TRD_RS08355	COG1007	ATP synthesis coupled electron transport
TRD_RS08370	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
TRD_RS08375	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
TRD_RS08385	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
TRD_RS08400	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
TRD_RS08405	COG0012	GTP binding
TRD_RS08420	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
TRD_RS08425	COG0045	succinate-CoA ligase (ADP-forming) activity
TRD_RS08430	COG1053	succinate dehydrogenase
TRD_RS08435	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
TRD_RS08440	COG0022	dehydrogenase e1 component
TRD_RS08450	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
TRD_RS08485	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
TRD_RS08490	COG0552	protein localization to endoplasmic reticulum
TRD_RS08495	COG2003	Belongs to the UPF0758 family
TRD_RS08520	COG1012	belongs to the aldehyde dehydrogenase family
TRD_RS08535	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
TRD_RS08540	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
TRD_RS08545	COG0581	inorganic phosphate transmembrane transporter activity
TRD_RS08550	COG0573	inorganic phosphate transmembrane transporter activity
TRD_RS08555	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
TRD_RS08560	COG0745	RESPONSE REGULATOR receiver
TRD_RS08575	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
TRD_RS08590	COG4166	transmembrane transport
TRD_RS08595	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TRD_RS08605	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
TRD_RS08605	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
TRD_RS08610	COG0728	peptidoglycan biosynthetic process
TRD_RS08615	COG0402	S-adenosylhomocysteine deaminase activity
TRD_RS08640	COG2514	catechol 2,3-dioxygenase activity
TRD_RS08645	COG1363	Peptidase, m42
TRD_RS08650	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
TRD_RS08655	COG0762	integral membrane protein
TRD_RS08675	COG4481	Protein conserved in bacteria
TRD_RS08680	COG2814	Major facilitator Superfamily
TRD_RS08690	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TRD_RS08695	COG0601	transmembrane transport
TRD_RS08700	COG0747	negative chemotaxis
TRD_RS08705	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
TRD_RS08715	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
TRD_RS08775	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
TRD_RS08785	COG1418	mRNA catabolic process
TRD_RS08795	COG1716	ATPase activity
TRD_RS08795	COG1131	(ABC) transporter
TRD_RS08795	COG0842	Transport permease protein
TRD_RS08825	COG2154	pterin-4-alpha-carbinolamine dehydratase
TRD_RS08835	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
TRD_RS08850	COG0438	transferase activity, transferring glycosyl groups
TRD_RS08855	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
TRD_RS08860	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
TRD_RS08865	COG0537	adenosine 5'-monophosphoramidase activity
TRD_RS08895	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
TRD_RS08920	COG0215	cysteine-tRNA ligase activity
TRD_RS08930	COG1252	NADH dehydrogenase
TRD_RS08955	COG0561	phosphatase activity
TRD_RS08985	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
TRD_RS08990	COG2894	cell division
TRD_RS08995	COG0850	regulation of cytokinetic process
TRD_RS09000	COG0768	penicillin binding
TRD_RS09015	COG0366	Alpha amylase catalytic
TRD_RS09030	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
TRD_RS09045	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
TRD_RS09055	COG1077	Cell shape determining protein MreB Mrl
TRD_RS09065	COG1597	lipid kinase activity
TRD_RS09075	COG1063	alcohol dehydrogenase
TRD_RS09080	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
TRD_RS09085	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
TRD_RS09090	COG4948	Mandelate Racemase Muconate Lactonizing
TRD_RS09105	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
TRD_RS09110	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TRD_RS09120	COG0747	negative chemotaxis
TRD_RS09125	COG0444	Belongs to the ABC transporter superfamily
TRD_RS09130	COG4608	Belongs to the ABC transporter superfamily
TRD_RS09135	COG4948	Mandelate Racemase Muconate Lactonizing
TRD_RS09140	COG4948	Mandelate Racemase Muconate Lactonizing
TRD_RS09145	COG4948	Mandelate Racemase Muconate Lactonizing
TRD_RS09155	COG1376	ErfK ybiS ycfS ynhG family protein
TRD_RS09170	COG2333	competence protein COMEC
TRD_RS09170	COG0658	competence protein
TRD_RS09180	COG0438	transferase activity, transferring glycosyl groups
TRD_RS09190	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
TRD_RS09210	COG0437	4 iron, 4 sulfur cluster binding
TRD_RS09215	COG3383	formate dehydrogenase (NAD+) activity
TRD_RS09215	COG0243	molybdopterin cofactor binding
TRD_RS09230	COG0589	response to stress
TRD_RS09265	COG0668	transmembrane transport
TRD_RS09335	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
TRD_RS09415	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
TRD_RS09750	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
TRD_RS10025	COG0247	lactate metabolic process
TRD_RS10025	COG2181	nitrate reductase activity
TRD_RS10195	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
TRD_RS10285	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
TRD_RS10525	COG1363	Peptidase, m42
TRD_RS11045	COG0601	transmembrane transport
TRD_RS11305	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
TRD_RS11305	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
TRD_RS11560	COG2226	methyltransferase
TRD_RS11955	COG0442	prolyl-tRNA aminoacylation
TRD_RS12190	COG0438	transferase activity, transferring glycosyl groups
TRD_RS12335	COG0305	Participates in initiation and elongation during chromosome replication
TRD_RS12535	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
TRD_RS12540	COG0084	hydrolase, TatD family'
TRD_RS12565	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
TRD_RS12605	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
TRD_RS12610	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
TRD_RS12635	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
TRD_RS13135	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
TRD_RS13135	COG0825	malonyl-CoA metabolic process
TRD_RS13355	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
TRD_RS13390	COG5001	Diguanylate cyclase
TRD_RS13425	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
TRD_RS13465	COG1686	Belongs to the peptidase S11 family
TRD_RS13470	COG1686	Belongs to the peptidase S11 family
TRD_RS13475	COG3942	CHAP domain
TRD_RS13475	COG1388	LysM domain
TRD_RS13490	COG1686	Belongs to the peptidase S11 family
TRD_RS13535	COG2843	Capsule synthesis protein
TRD_RS13540	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
TRD_RS13545	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
TRD_RS13550	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
TRD_RS13570	COG2176	DNA-directed DNA polymerase activity
TRD_RS13575	COG0181	hydroxymethylbilane synthase activity
TRD_RS13580	COG3409	Peptidoglycan-binding domain 1 protein
TRD_RS13580	COG3429	Glucose-6-phosphate dehydrogenase subunit
TRD_RS13590	COG1309	transcriptional regulator
TRD_RS13595	COG0596	Alpha beta hydrolase
TRD_RS13610	COG1408	metallophosphoesterase
TRD_RS13615	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
TRD_RS13620	COG2205	protein histidine kinase activity
TRD_RS13630	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
TRD_RS13635	COG1316	TRANSCRIPTIONal
TRD_RS13665	COG0189	ligase activity
TRD_RS13675	COG0463	Glycosyl transferase, family 2
TRD_RS13685	COG5632	N-Acetylmuramoyl-L-alanine amidase
TRD_RS13685	COG3409	Peptidoglycan-binding domain 1 protein
TRD_RS13700	COG0671	phosphoesterase, PA-phosphatase related
TRD_RS13705	COG1722	exodeoxyribonuclease VII activity
TRD_RS13735	COG5001	Diguanylate cyclase
TRD_RS13745	COG0375	protein maturation
TRD_RS13755	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
TRD_RS13765	COG5001	Diguanylate cyclase
TRD_RS13775	COG0739	heme binding
TRD_RS13775	COG0741	lytic transglycosylase activity
TRD_RS13775	COG1196	nuclear chromosome segregation
TRD_RS13915	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
TRD_RS13920	COG0322	excinuclease ABC activity
TRD_RS13995	COG0587	DNA-directed DNA polymerase activity