locus-tag	class	description
H9L16_RS00025	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
H9L16_RS00055	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H9L16_RS00075	COG2010	Cytochrome c
H9L16_RS00085	COG0348	domain, Protein
H9L16_RS00095	COG2217	Heavy metal translocating P-type atpase
H9L16_RS00115	COG2197	response regulator
H9L16_RS00145	COG0367	asparagine synthase
H9L16_RS00155	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H9L16_RS00160	COG1393	Belongs to the ArsC family
H9L16_RS00175	COG0024	Methionine aminopeptidase
H9L16_RS00180	COG0052	Belongs to the universal ribosomal protein uS2 family
H9L16_RS00185	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
H9L16_RS00210	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
H9L16_RS00215	COG0575	Belongs to the CDS family
H9L16_RS00220	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
H9L16_RS00225	COG0750	zinc metalloprotease
H9L16_RS00245	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H9L16_RS00250	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H9L16_RS00255	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
H9L16_RS00270	COG2208	phosphoserine phosphatase activity
H9L16_RS00270	COG2770	Histidine kinase
H9L16_RS00280	COG0037	tRNA processing
H9L16_RS00285	COG1722	exodeoxyribonuclease VII activity
H9L16_RS00290	COG0142	geranyltranstransferase activity
H9L16_RS00300	COG4783	chaperone-mediated protein folding
H9L16_RS00325	COG0312	modulator of DNA gyrase
H9L16_RS00335	COG0312	modulator of DNA gyrase
H9L16_RS00350	COG0424	maF-like protein
H9L16_RS00365	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
H9L16_RS00370	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
H9L16_RS00395	COG0495	leucyl-tRNA aminoacylation
H9L16_RS00435	COG3118	belongs to the thioredoxin family
H9L16_RS00475	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
H9L16_RS00480	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
H9L16_RS00490	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
H9L16_RS00540	COG4966	pilus assembly protein PilW
H9L16_RS00555	COG3275	phosphorelay sensor kinase activity
H9L16_RS00560	COG1611	Belongs to the LOG family
H9L16_RS00570	COG2095	MarC family integral membrane protein
H9L16_RS00575	COG1028	Short-chain dehydrogenase reductase Sdr
H9L16_RS00580	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
H9L16_RS00605	COG2835	tetraacyldisaccharide 4'-kinase activity
H9L16_RS00625	COG2969	positive regulation of protein catabolic process
H9L16_RS00630	COG0625	glutathione transferase activity
H9L16_RS00635	COG2857	Cytochrome c1
H9L16_RS00640	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
H9L16_RS00645	COG0723	plastoquinol--plastocyanin reductase activity
H9L16_RS00650	COG0741	lytic transglycosylase activity
H9L16_RS00655	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
H9L16_RS00665	COG1574	metal-dependent hydrolase with the TIM-barrel fold
H9L16_RS00670	COG1702	phosphate starvation-inducible protein PhoH
H9L16_RS00680	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
H9L16_RS00690	COG4535	Mg2 and Co2 transporter CorC
H9L16_RS00710	COG0823	Involved in the tonB-independent uptake of proteins
H9L16_RS00710	COG1506	peptidase
H9L16_RS00715	COG1297	OPT oligopeptide transporter protein
H9L16_RS00720	COG3104	oligopeptide transport
H9L16_RS00755	COG1253	flavin adenine dinucleotide binding
H9L16_RS00765	COG3300	MHYT domain
H9L16_RS00765	COG5001	Diguanylate cyclase
H9L16_RS00785	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
H9L16_RS00790	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
H9L16_RS00795	COG1862	Preprotein translocase
H9L16_RS00800	COG0343	queuine tRNA-ribosyltransferase activity
H9L16_RS00805	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
H9L16_RS00810	COG1522	sequence-specific DNA binding
H9L16_RS00815	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
H9L16_RS00820	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
H9L16_RS00835	COG4206	TonB-dependent receptor
H9L16_RS00850	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
H9L16_RS00865	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
H9L16_RS00880	COG0742	ribosomal rna small subunit methyltransferase
H9L16_RS00885	COG0552	protein localization to endoplasmic reticulum
H9L16_RS00900	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
H9L16_RS00925	COG1960	acyl-CoA dehydrogenase activity
H9L16_RS00965	COG1946	Acyl-CoA thioesterase
H9L16_RS00980	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
H9L16_RS00995	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
H9L16_RS01020	COG1073	alpha beta
H9L16_RS01105	COG0142	geranyltranstransferase activity
H9L16_RS01115	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
H9L16_RS01125	COG0527	aspartate kinase activity
H9L16_RS01135	COG0384	phenazine biosynthesis protein PhzF
H9L16_RS01150	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
H9L16_RS01205	COG1959	2 iron, 2 sulfur cluster binding
H9L16_RS01210	COG0719	Fe-S assembly protein
H9L16_RS01215	COG0396	ATPase activity
H9L16_RS01220	COG0719	Fe-S assembly protein
H9L16_RS01225	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
H9L16_RS01245	COG4774	siderophore transport
H9L16_RS01255	COG4771	TonB-dependent receptor
H9L16_RS01300	COG2261	transglycosylase associated protein
H9L16_RS01305	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
H9L16_RS01310	COG4208	sulfate ABC transporter
H9L16_RS01320	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
H9L16_RS01335	COG1959	2 iron, 2 sulfur cluster binding
H9L16_RS01340	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
H9L16_RS01345	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
H9L16_RS01350	COG0175	sulfate reduction
H9L16_RS01360	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
H9L16_RS01360	COG1648	precorrin-2 dehydrogenase activity
H9L16_RS01375	COG3178	'Phosphotransferase
H9L16_RS01380	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
H9L16_RS01390	COG0628	permease
H9L16_RS01410	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
H9L16_RS01420	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
H9L16_RS01435	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
H9L16_RS01450	COG1137	ATPase activity
H9L16_RS01480	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
H9L16_RS01485	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
H9L16_RS01490	COG2239	Acts as a magnesium transporter
H9L16_RS01505	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
H9L16_RS01510	COG1678	Uncharacterized ACR, COG1678
H9L16_RS01525	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
H9L16_RS01545	COG0259	pyridoxamine-phosphate oxidase activity
H9L16_RS01570	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
H9L16_RS01655	COG0582	viral genome integration into host DNA
H9L16_RS01660	COG2353	YceI-like domain
H9L16_RS01675	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
H9L16_RS01675	COG1648	precorrin-2 dehydrogenase activity
H9L16_RS01685	COG1760	l-serine dehydratase
H9L16_RS01690	COG5002	protein histidine kinase activity
H9L16_RS01690	COG5001	Diguanylate cyclase
H9L16_RS01695	COG0460	homoserine dehydrogenase
H9L16_RS01695	COG0527	aspartate kinase activity
H9L16_RS01700	COG0626	cystathionine gamma-synthase activity
H9L16_RS01705	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
H9L16_RS01710	COG0739	heme binding
H9L16_RS01715	COG0515	serine threonine protein kinase
H9L16_RS01720	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
H9L16_RS01730	COG1272	protein, Hemolysin III
H9L16_RS01735	COG0517	IMP dehydrogenase activity
H9L16_RS01740	COG0463	Glycosyl transferase, family 2
H9L16_RS01745	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
H9L16_RS01750	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
H9L16_RS01790	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
H9L16_RS01795	COG1309	transcriptional regulator
H9L16_RS01800	COG1960	acyl-CoA dehydrogenase activity
H9L16_RS01810	COG3759	membrane
H9L16_RS01830	COG0501	Belongs to the peptidase M48B family
H9L16_RS01835	COG1704	LemA family
H9L16_RS01850	COG0509	glycine decarboxylation via glycine cleavage system
H9L16_RS01855	COG0404	The glycine cleavage system catalyzes the degradation of glycine
H9L16_RS01865	COG0330	HflC and HflK could
H9L16_RS01900	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
H9L16_RS01905	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H9L16_RS01910	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
H9L16_RS01950	COG2308	Evidence 4 Homologs of previously reported genes of
H9L16_RS01970	COG5001	Diguanylate cyclase
H9L16_RS01975	COG3706	GGDEF domain
H9L16_RS01980	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
H9L16_RS01990	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
H9L16_RS01995	COG0642	Histidine kinase
H9L16_RS02000	COG0745	RESPONSE REGULATOR receiver
H9L16_RS02005	COG0189	ligase activity
H9L16_RS02010	COG4067	protein conserved in archaea
H9L16_RS02010	COG0189	ligase activity
H9L16_RS02030	COG2022	thiamine diphosphate biosynthetic process
H9L16_RS02040	COG3273	potassium ion transport
H9L16_RS02040	COG0471	metal ion transport
H9L16_RS02060	COG1970	mechanosensitive ion channel activity
H9L16_RS02070	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H9L16_RS02075	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H9L16_RS02090	COG3588	fructose-bisphosphate aldolase
H9L16_RS02120	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
H9L16_RS02130	COG0730	response to heat
H9L16_RS02145	COG0427	acetyl-CoA hydrolase
H9L16_RS02150	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
H9L16_RS02155	COG1301	dicarboxylic acid transport
H9L16_RS02185	COG0714	Associated with various cellular activities
H9L16_RS02225	COG0372	Belongs to the citrate synthase family
H9L16_RS02230	COG0254	rRNA binding
H9L16_RS02265	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
H9L16_RS02270	COG0640	Transcriptional regulator
H9L16_RS02290	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
H9L16_RS02305	COG1561	YicC-like family, N-terminal region
H9L16_RS02310	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
H9L16_RS02315	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
H9L16_RS02320	COG0635	Involved in the biosynthesis of porphyrin-containing compound
H9L16_RS02335	COG0006	proline dipeptidase activity
H9L16_RS02340	COG0006	proline dipeptidase activity
H9L16_RS02345	COG3079	Belongs to the UPF0149 family
H9L16_RS02370	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
H9L16_RS02395	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
H9L16_RS02430	COG1773	rubredoxin
H9L16_RS02440	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
H9L16_RS02445	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H9L16_RS02460	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
H9L16_RS02470	COG0346	lactoylglutathione lyase activity
H9L16_RS02485	COG1595	DNA-templated transcription, initiation
H9L16_RS02490	COG1028	Short-chain dehydrogenase reductase Sdr
H9L16_RS02495	COG0586	Pfam SNARE associated Golgi protein
H9L16_RS02505	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
H9L16_RS02525	COG1872	DUF167
H9L16_RS02535	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
H9L16_RS02540	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
H9L16_RS02580	COG0745	RESPONSE REGULATOR receiver
H9L16_RS02585	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
H9L16_RS02625	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
H9L16_RS02630	COG0473	3-isopropylmalate dehydrogenase activity
H9L16_RS02635	COG0066	3-isopropylmalate dehydratase activity
H9L16_RS02640	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
H9L16_RS02660	COG1309	transcriptional regulator
H9L16_RS02665	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
H9L16_RS02670	COG1538	Outer membrane efflux protein
H9L16_RS02675	COG1519	Transferase
H9L16_RS02685	COG1560	Kdo2-lipid A biosynthetic process
H9L16_RS02700	COG0297	glycogen (starch) synthase activity
H9L16_RS02710	COG1741	Belongs to the pirin family
H9L16_RS02715	COG2353	YceI-like domain
H9L16_RS02720	COG0778	Nitroreductase
H9L16_RS02730	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
H9L16_RS02735	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
H9L16_RS02765	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
H9L16_RS02795	COG0459	protein refolding
H9L16_RS02820	COG2192	nodulation
H9L16_RS02845	COG4232	protein-disulfide reductase activity
H9L16_RS02850	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
H9L16_RS02855	COG0511	ligase activity, forming carbon-carbon bonds
H9L16_RS02860	COG0439	Biotin carboxylase
H9L16_RS02880	COG2264	protein methyltransferase activity
H9L16_RS02890	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
H9L16_RS02895	COG0138	bifunctional purine biosynthesis protein purh
H9L16_RS02900	COG0151	Belongs to the GarS family
H9L16_RS02905	COG0436	Aminotransferase
H9L16_RS02910	COG1902	pentaerythritol trinitrate reductase activity
H9L16_RS02920	COG4181	ATPase activity
H9L16_RS02935	COG3384	dioxygenase
H9L16_RS02945	COG2197	response regulator
H9L16_RS02960	COG3265	gluconokinase activity
H9L16_RS02965	COG3459	Glycosyltransferase 36 associated
H9L16_RS02970	COG2211	Major facilitator Superfamily
H9L16_RS03015	COG5002	protein histidine kinase activity
H9L16_RS03015	COG0784	Response regulator, receiver
H9L16_RS03015	COG2205	protein histidine kinase activity
H9L16_RS03085	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
H9L16_RS03125	COG1752	Esterase of the alpha-beta hydrolase superfamily
H9L16_RS03130	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H9L16_RS03135	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H9L16_RS03140	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
H9L16_RS03150	COG1956	GAF domain-containing protein
H9L16_RS03160	COG4206	TonB-dependent receptor
H9L16_RS03175	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
H9L16_RS03180	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H9L16_RS03190	COG1136	(ABC) transporter
H9L16_RS03190	COG0577	efflux transmembrane transporter activity
H9L16_RS03195	COG0577	efflux transmembrane transporter activity
H9L16_RS03195	COG1136	(ABC) transporter
H9L16_RS03200	COG0577	efflux transmembrane transporter activity
H9L16_RS03215	COG4191	Histidine kinase
H9L16_RS03215	COG2205	protein histidine kinase activity
H9L16_RS03215	COG0745	RESPONSE REGULATOR receiver
H9L16_RS03220	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
H9L16_RS03235	COG0355	proton-transporting ATP synthase activity, rotational mechanism
H9L16_RS03240	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
H9L16_RS03250	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
H9L16_RS03260	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
H9L16_RS03270	COG0356	it plays a direct role in the translocation of protons across the membrane
H9L16_RS03280	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
H9L16_RS03290	COG0697	spore germination
H9L16_RS03295	COG1666	GTP binding
H9L16_RS03305	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H9L16_RS03310	COG1187	pseudouridine synthase activity
H9L16_RS03315	COG2813	Specifically methylates the guanine in position
H9L16_RS03345	COG4941	Belongs to the sigma-70 factor family
H9L16_RS03360	COG2764	glyoxalase bleomycin resistance protein dioxygenase
H9L16_RS03365	COG3795	YCII-related domain
H9L16_RS03375	COG3795	YCII-related domain
H9L16_RS03380	COG1793	dna ligase
H9L16_RS03385	COG2203	Gaf domain
H9L16_RS03385	COG4251	negative regulation of phosphorylation
H9L16_RS03385	COG5001	Diguanylate cyclase
H9L16_RS03385	COG3706	GGDEF domain
H9L16_RS03390	COG2814	Major facilitator Superfamily
H9L16_RS03395	COG2972	Histidine kinase
H9L16_RS03435	COG0519	Catalyzes the synthesis of GMP from XMP
H9L16_RS03445	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
H9L16_RS03505	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
H9L16_RS03510	COG2202	Pas domain
H9L16_RS03510	COG2205	protein histidine kinase activity
H9L16_RS03515	COG0784	Response regulator, receiver
H9L16_RS03560	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H9L16_RS03575	COG1162	GTPase activity
H9L16_RS03580	COG0436	Aminotransferase
H9L16_RS03590	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
H9L16_RS03605	COG1228	amidohydrolase
H9L16_RS03615	COG1307	EDD domain protein, DegV family
H9L16_RS03640	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
H9L16_RS03660	COG2815	serine threonine protein kinase
H9L16_RS03660	COG0515	serine threonine protein kinase
H9L16_RS03675	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
H9L16_RS03695	COG0366	Alpha amylase catalytic
H9L16_RS03710	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
H9L16_RS03730	COG0730	response to heat
H9L16_RS03735	COG0741	lytic transglycosylase activity
H9L16_RS03740	COG0617	tRNA 3'-terminal CCA addition
H9L16_RS03765	COG0300	oxidoreductase activity
H9L16_RS03770	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
H9L16_RS03775	COG0668	transmembrane transport
H9L16_RS03780	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
H9L16_RS03800	COG0358	DNA primase activity
H9L16_RS03810	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
H9L16_RS03810	COG2169	Transcriptional regulator
H9L16_RS03820	COG0109	protoheme IX farnesyltransferase activity
H9L16_RS03825	COG1612	heme a metabolic process
H9L16_RS03850	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
H9L16_RS03860	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
H9L16_RS03865	COG1565	acr, cog1565
H9L16_RS03865	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
H9L16_RS03885	COG0793	Belongs to the peptidase S41A family
H9L16_RS03890	COG4942	peptidase
H9L16_RS03895	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
H9L16_RS03945	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
H9L16_RS03950	COG0739	heme binding
H9L16_RS03955	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
H9L16_RS03965	COG2814	Major facilitator Superfamily
H9L16_RS03985	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
H9L16_RS04000	COG2003	Belongs to the UPF0758 family
H9L16_RS04005	COG0018	arginyl-trna synthetase
H9L16_RS04025	COG4221	oxidoreductase activity
H9L16_RS04045	COG2755	lipolytic protein G-D-S-L family
H9L16_RS04045	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
H9L16_RS04050	COG1166	arginine decarboxylase activity
H9L16_RS04065	COG3706	GGDEF domain
H9L16_RS04075	COG2960	long-chain fatty acid transporting porin activity
H9L16_RS04080	COG0606	chelatase, subunit chli
H9L16_RS04105	COG3706	GGDEF domain
H9L16_RS04110	COG2224	Isocitrate lyase
H9L16_RS04115	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
H9L16_RS04120	COG0583	DNA-binding transcription factor activity
H9L16_RS04130	COG4566	intracellular signal transduction
H9L16_RS04165	COG0564	pseudouridine synthase activity
H9L16_RS04220	COG0318	PFAM AMP-dependent synthetase and ligase
H9L16_RS04225	COG0727	PFAM Uncharacterised protein family (UPF0153)
H9L16_RS04235	COG0596	Alpha beta hydrolase
H9L16_RS04245	COG2194	sulfuric ester hydrolase activity
H9L16_RS04255	COG0745	RESPONSE REGULATOR receiver
H9L16_RS04260	COG3850	Histidine kinase
H9L16_RS04260	COG5002	protein histidine kinase activity
H9L16_RS04265	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
H9L16_RS04275	COG0612	Peptidase, M16
H9L16_RS04285	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
H9L16_RS04305	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
H9L16_RS04310	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
H9L16_RS04315	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
H9L16_RS04345	COG0408	coproporphyrinogen oxidase activity
H9L16_RS04350	COG2323	membrane
H9L16_RS04365	COG1132	(ABC) transporter
H9L16_RS04375	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H9L16_RS04380	COG2267	carboxylic ester hydrolase activity
H9L16_RS04385	COG0210	DNA helicase
H9L16_RS04405	COG0475	glutathione-regulated potassium exporter activity
H9L16_RS04435	COG1609	Transcriptional regulator
H9L16_RS04440	COG1472	Belongs to the glycosyl hydrolase 3 family
H9L16_RS04450	COG0625	glutathione transferase activity
H9L16_RS04460	COG0463	Glycosyl transferase, family 2
H9L16_RS04480	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
H9L16_RS04490	COG0714	Associated with various cellular activities
H9L16_RS04515	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
H9L16_RS04535	COG0357	Ribosomal RNA small subunit methyltransferase G
H9L16_RS04540	COG1192	Involved in chromosome partitioning
H9L16_RS04545	COG1475	DNA binding
H9L16_RS04550	COG0463	Glycosyl transferase, family 2
H9L16_RS04565	COG0227	Belongs to the bacterial ribosomal protein bL28 family
H9L16_RS04570	COG0267	Belongs to the bacterial ribosomal protein bL33 family
H9L16_RS04600	COG1690	Belongs to the RtcB family
H9L16_RS04605	COG0784	Response regulator, receiver
H9L16_RS04605	COG2205	protein histidine kinase activity
H9L16_RS04640	COG0457	Tetratricopeptide repeat
H9L16_RS04650	COG3590	peptidase
H9L16_RS04695	COG1725	Transcriptional regulator
H9L16_RS04700	COG1131	(ABC) transporter
H9L16_RS04730	COG3118	belongs to the thioredoxin family
H9L16_RS04735	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
H9L16_RS04745	COG0515	serine threonine protein kinase
H9L16_RS04755	COG0210	DNA helicase
H9L16_RS04770	COG2937	Belongs to the GPAT DAPAT family
H9L16_RS04775	COG3706	GGDEF domain
H9L16_RS04790	COG0037	tRNA processing
H9L16_RS04820	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
H9L16_RS04860	COG0518	GMP synthase (glutamine-hydrolyzing) activity
H9L16_RS04860	COG0519	Catalyzes the synthesis of GMP from XMP
H9L16_RS04865	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
H9L16_RS04890	COG0729	surface antigen
H9L16_RS04895	COG2911	Protein conserved in bacteria
H9L16_RS04905	COG0515	serine threonine protein kinase
H9L16_RS04905	COG2815	serine threonine protein kinase
H9L16_RS04925	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
H9L16_RS04935	COG0697	spore germination
H9L16_RS04950	COG2267	carboxylic ester hydrolase activity
H9L16_RS04960	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
H9L16_RS04965	COG1040	competence protein
H9L16_RS05015	COG2945	thiolester hydrolase activity
H9L16_RS05020	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
H9L16_RS05030	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
H9L16_RS05030	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
H9L16_RS05035	COG1652	LysM domain
H9L16_RS05055	COG1187	pseudouridine synthase activity
H9L16_RS05070	COG1643	Atp-dependent helicase
H9L16_RS05075	COG2356	endonuclease I
H9L16_RS05080	COG0084	hydrolase, TatD family'
H9L16_RS05090	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H9L16_RS05150	COG0842	Transport permease protein
H9L16_RS05155	COG1131	(ABC) transporter
H9L16_RS05190	COG4555	ABC transporter
H9L16_RS05205	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
H9L16_RS05225	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
H9L16_RS05235	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
H9L16_RS05240	COG0187	DNA topoisomerase II activity
H9L16_RS05290	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H9L16_RS05300	COG1741	Belongs to the pirin family
H9L16_RS05305	COG0490	domain, Protein
H9L16_RS05305	COG0471	metal ion transport
H9L16_RS05310	COG2202	Pas domain
H9L16_RS05310	COG2205	protein histidine kinase activity
H9L16_RS05315	COG0784	Response regulator, receiver
H9L16_RS05335	COG3186	Phenylalanine-4-hydroxylase
H9L16_RS05340	COG1752	Esterase of the alpha-beta hydrolase superfamily
H9L16_RS05345	COG3647	Membrane
H9L16_RS05355	COG0861	Integral membrane protein TerC family
H9L16_RS05360	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
H9L16_RS05370	COG1322	Protein conserved in bacteria
H9L16_RS05380	COG2853	Lipoprotein
H9L16_RS05400	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
H9L16_RS05405	COG1127	ABC transporter
H9L16_RS05410	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
H9L16_RS05415	COG1074	ATP-dependent DNA helicase activity
H9L16_RS05425	COG3550	peptidyl-serine autophosphorylation
H9L16_RS05475	COG0640	Transcriptional regulator
H9L16_RS05505	COG4772	TonB-dependent receptor
H9L16_RS05585	COG3507	Belongs to the glycosyl hydrolase 43 family
H9L16_RS05595	COG0583	DNA-binding transcription factor activity
H9L16_RS05630	COG0302	gtp cyclohydrolase
H9L16_RS05635	COG0492	ferredoxin-NADP+ reductase activity
H9L16_RS05675	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
H9L16_RS05685	COG2188	Transcriptional regulator
H9L16_RS05695	COG0738	Major facilitator superfamily
H9L16_RS05700	COG0837	glucose binding
H9L16_RS05710	COG3525	Glycosyl hydrolase, family 20, catalytic domain
H9L16_RS05755	COG1881	PFAM PEBP family protein
H9L16_RS05765	COG1968	undecaprenyl-diphosphatase activity
H9L16_RS05770	COG0174	glutamine synthetase
H9L16_RS05785	COG0004	ammonium transporteR
H9L16_RS05805	COG3023	N-Acetylmuramoyl-L-alanine amidase
H9L16_RS05815	COG0739	heme binding
H9L16_RS05820	COG1376	ErfK ybiS ycfS ynhG family protein
H9L16_RS05825	COG3852	Histidine kinase
H9L16_RS05830	COG2204	response regulator
H9L16_RS05835	COG2032	superoxide dismutase activity
H9L16_RS05860	COG0183	Belongs to the thiolase family
H9L16_RS05865	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
H9L16_RS05870	COG0823	Involved in the tonB-independent uptake of proteins
H9L16_RS05870	COG1506	peptidase
H9L16_RS05870	COG4946	Tricorn protease homolog
H9L16_RS05875	COG1271	oxidase subunit
H9L16_RS05885	COG1294	oxidase, subunit
H9L16_RS05890	COG3100	YcgL domain-containing protein
H9L16_RS05920	COG0515	serine threonine protein kinase
H9L16_RS05940	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
H9L16_RS05945	COG3118	belongs to the thioredoxin family
H9L16_RS05955	COG0515	serine threonine protein kinase
H9L16_RS05955	COG2815	serine threonine protein kinase
H9L16_RS05975	COG2884	Cell division ATP-binding protein ftsE
H9L16_RS05980	COG2177	Part of the ABC transporter FtsEX involved in
H9L16_RS05985	COG2201	protein-glutamate methylesterase activity
H9L16_RS05990	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
H9L16_RS05995	COG0339	signal peptide processing
H9L16_RS06000	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
H9L16_RS06005	COG2860	membrane
H9L16_RS06010	COG1252	NADH dehydrogenase
H9L16_RS06020	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
H9L16_RS06035	COG4585	Histidine kinase
H9L16_RS06050	COG0534	Mate efflux family protein
H9L16_RS06055	COG0616	signal peptide processing
H9L16_RS06090	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
H9L16_RS06110	COG1609	Transcriptional regulator
H9L16_RS06120	COG1028	Short-chain dehydrogenase reductase Sdr
H9L16_RS06125	COG2755	lipolytic protein G-D-S-L family
H9L16_RS06135	COG1028	Short-chain dehydrogenase reductase Sdr
H9L16_RS06140	COG2205	protein histidine kinase activity
H9L16_RS06140	COG2202	Pas domain
H9L16_RS06180	COG0583	DNA-binding transcription factor activity
H9L16_RS06195	COG2080	2 iron, 2 sulfur cluster binding
H9L16_RS06200	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
H9L16_RS06205	COG1529	Aldehyde oxidase and xanthine dehydrogenase
H9L16_RS06235	COG0493	'glutamate synthase
H9L16_RS06240	COG0070	glutamate synthase
H9L16_RS06240	COG0067	glutamate synthase
H9L16_RS06240	COG0069	glutamate synthase activity
H9L16_RS06245	COG0009	L-threonylcarbamoyladenylate synthase
H9L16_RS06260	COG2922	Belongs to the Smg family
H9L16_RS06265	COG0758	DNA mediated transformation
H9L16_RS06270	COG1652	LysM domain
H9L16_RS06280	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
H9L16_RS06285	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
H9L16_RS06285	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
H9L16_RS06290	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
H9L16_RS06325	COG1490	D-aminoacyl-tRNA deacylase activity
H9L16_RS06330	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
H9L16_RS06335	COG3537	Alpha-1,2-mannosidase
H9L16_RS06365	COG1335	isochorismatase
H9L16_RS06375	COG2323	membrane
H9L16_RS06385	COG1285	pathogenesis
H9L16_RS06405	COG1028	Short-chain dehydrogenase reductase Sdr
H9L16_RS06415	COG2259	Doxx family
H9L16_RS06480	COG0181	hydroxymethylbilane synthase activity
H9L16_RS06490	COG3302	dmso reductase anchor subunit
H9L16_RS06495	COG0393	Putative heavy-metal-binding
H9L16_RS06500	COG0437	4 iron, 4 sulfur cluster binding
H9L16_RS06510	COG0243	molybdopterin cofactor binding
H9L16_RS06530	COG1505	serine-type exopeptidase activity
H9L16_RS06540	COG2832	Protein of unknown function (DUF454)
H9L16_RS06550	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
H9L16_RS06570	COG1215	transferase activity, transferring glycosyl groups
H9L16_RS06580	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
H9L16_RS06645	COG0308	aminopeptidase N
H9L16_RS06650	COG0596	Alpha beta hydrolase
H9L16_RS06650	COG0508	dehydrogenase complex catalyzes the overall conversion of
H9L16_RS06660	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
H9L16_RS06665	COG1077	Cell shape determining protein MreB Mrl
H9L16_RS06670	COG1792	Involved in formation and maintenance of cell shape
H9L16_RS06680	COG0768	penicillin binding
H9L16_RS06685	COG0772	Belongs to the SEDS family
H9L16_RS06705	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
H9L16_RS06710	COG1686	Belongs to the peptidase S11 family
H9L16_RS06735	COG1191	sigma factor activity
H9L16_RS06740	COG0515	serine threonine protein kinase
H9L16_RS06740	COG2815	serine threonine protein kinase
H9L16_RS06750	COG1522	sequence-specific DNA binding
H9L16_RS06755	COG0697	spore germination
H9L16_RS06775	COG0577	efflux transmembrane transporter activity
H9L16_RS06780	COG1136	(ABC) transporter
H9L16_RS06795	COG1131	(ABC) transporter
H9L16_RS06805	COG4585	Histidine kinase
H9L16_RS06810	COG2197	response regulator
H9L16_RS06825	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
H9L16_RS06855	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H9L16_RS06910	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
H9L16_RS06960	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
H9L16_RS06965	COG5001	Diguanylate cyclase
H9L16_RS06965	COG5002	protein histidine kinase activity
H9L16_RS06965	COG3447	MASE1 domain protein
H9L16_RS06975	COG3040	lipid binding
H9L16_RS07000	COG2824	Alkylphosphonate utilization operon protein PhnA
H9L16_RS07015	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
H9L16_RS07020	COG0686	Belongs to the AlaDH PNT family
H9L16_RS07025	COG1522	sequence-specific DNA binding
H9L16_RS07035	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
H9L16_RS07040	COG0583	DNA-binding transcription factor activity
H9L16_RS07055	COG1262	PFAM Formylglycine-generating sulfatase enzyme
H9L16_RS07105	COG2814	Major facilitator Superfamily
H9L16_RS07120	COG0318	PFAM AMP-dependent synthetase and ligase
H9L16_RS07130	COG1028	Short-chain dehydrogenase reductase Sdr
H9L16_RS07135	COG2828	Protein conserved in bacteria
H9L16_RS07145	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
H9L16_RS07170	COG3228	Belongs to the MtfA family
H9L16_RS07180	COG1461	Dihydroxyacetone kinase
H9L16_RS07185	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
H9L16_RS07195	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
H9L16_RS07210	COG0010	Belongs to the arginase family
H9L16_RS07230	COG0180	Tryptophanyl-tRNA synthetase
H9L16_RS07265	COG3483	tryptophan 2,3-dioxygenase activity
H9L16_RS07270	COG3104	oligopeptide transport
H9L16_RS07285	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
H9L16_RS07295	COG1320	monovalent cation:proton antiporter activity
H9L16_RS07300	COG2212	antiporter activity
H9L16_RS07310	COG0651	ATP synthesis coupled electron transport
H9L16_RS07315	COG1006	Multisubunit Na H antiporter MnhC subunit
H9L16_RS07320	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
H9L16_RS07320	COG2111	Na H antiporter
H9L16_RS07350	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
H9L16_RS07355	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
H9L16_RS07370	COG2706	6-phosphogluconolactonase activity
H9L16_RS07375	COG1597	lipid kinase activity
H9L16_RS07395	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
H9L16_RS07400	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
H9L16_RS07405	COG4242	Belongs to the peptidase S51 family
H9L16_RS07410	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
H9L16_RS07410	COG0189	ligase activity
H9L16_RS07415	COG0189	ligase activity
H9L16_RS07415	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
H9L16_RS07420	COG2329	Antibiotic biosynthesis monooxygenase
H9L16_RS07425	COG0134	indole-3-glycerol-phosphate synthase activity
H9L16_RS07450	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
H9L16_RS07465	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
H9L16_RS07470	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
H9L16_RS07475	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
H9L16_RS07495	COG0625	glutathione transferase activity
H9L16_RS07505	COG2885	chlorophyll binding
H9L16_RS07520	COG0626	cystathionine gamma-synthase activity
H9L16_RS07545	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
H9L16_RS07550	COG1459	type II secretion system
H9L16_RS07605	COG0438	transferase activity, transferring glycosyl groups
H9L16_RS07605	COG1216	Glycosyl transferase, family 2
H9L16_RS07630	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
H9L16_RS07640	COG1368	sulfuric ester hydrolase activity
H9L16_RS07660	COG2086	electron transfer activity
H9L16_RS07705	COG3218	ABC-type transport auxiliary lipoprotein component
H9L16_RS07705	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
H9L16_RS07715	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
H9L16_RS07730	COG0442	prolyl-tRNA aminoacylation
H9L16_RS07745	COG1183	phosphatidylcholine synthase activity
H9L16_RS07770	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
H9L16_RS07780	COG0795	lipopolysaccharide-transporting ATPase activity
H9L16_RS07790	COG4974	Belongs to the 'phage' integrase family
H9L16_RS07795	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
H9L16_RS07800	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
H9L16_RS07800	COG0047	phosphoribosylformylglycinamidine synthase activity
H9L16_RS07805	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
H9L16_RS07810	COG1459	type II secretion system
H9L16_RS07815	COG2165	general secretion pathway protein
H9L16_RS07825	COG2165	general secretion pathway protein
H9L16_RS07830	COG4795	General secretion pathway protein
H9L16_RS07835	COG3156	type II secretion system protein K
H9L16_RS07840	COG3166	PFAM Fimbrial assembly family protein
H9L16_RS07855	COG1450	Type ii and iii secretion system protein
H9L16_RS07870	COG0284	orotidine-5'-phosphate decarboxylase activity
H9L16_RS07875	COG0488	(ABC) transporter
H9L16_RS07880	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
H9L16_RS07885	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
H9L16_RS07890	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H9L16_RS07890	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H9L16_RS07905	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
H9L16_RS07910	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
H9L16_RS07915	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
H9L16_RS07925	COG0792	nuclease activity
H9L16_RS07950	COG2001	Belongs to the MraZ family
H9L16_RS07960	COG3116	cell division
H9L16_RS07975	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
H9L16_RS07980	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
H9L16_RS08000	COG1181	Belongs to the D-alanine--D-alanine ligase family
H9L16_RS08005	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
H9L16_RS08020	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
H9L16_RS08030	COG0739	heme binding
H9L16_RS08035	COG0653	protein targeting
H9L16_RS08040	COG0494	nUDIX hydrolase
H9L16_RS08050	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
H9L16_RS08065	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
H9L16_RS08085	COG2226	methyltransferase
H9L16_RS08100	COG0438	transferase activity, transferring glycosyl groups
H9L16_RS08105	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
H9L16_RS08130	COG4969	Belongs to the N-Me-Phe pilin family
H9L16_RS08145	COG0045	succinate-CoA ligase (ADP-forming) activity
H9L16_RS08150	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
H9L16_RS08170	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H9L16_RS08175	COG0564	pseudouridine synthase activity
H9L16_RS08190	COG3011	Protein conserved in bacteria
H9L16_RS08195	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
H9L16_RS08205	COG1877	trehalose-phosphatase activity
H9L16_RS08220	COG0542	response to heat
H9L16_RS08230	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
H9L16_RS08230	COG4651	solute:proton antiporter activity
H9L16_RS08235	COG0488	(ABC) transporter
H9L16_RS08255	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
H9L16_RS08265	COG1764	response to oxidative stress
H9L16_RS08270	COG2267	carboxylic ester hydrolase activity
H9L16_RS08275	COG0217	transcriptional regulatory protein
H9L16_RS08280	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
H9L16_RS08285	COG0632	four-way junction helicase activity
H9L16_RS08295	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
H9L16_RS08300	COG2255	four-way junction helicase activity
H9L16_RS08305	COG0824	Thioesterase
H9L16_RS08310	COG0811	peptide transport
H9L16_RS08330	COG2885	chlorophyll binding
H9L16_RS08340	COG0602	queuosine metabolic process
H9L16_RS08345	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
H9L16_RS08360	COG1401	restriction endodeoxyribonuclease activity
H9L16_RS08405	COG1475	DNA binding
H9L16_RS08415	COG5410	chromosome segregation
H9L16_RS08460	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
H9L16_RS08465	COG1404	Belongs to the peptidase S8 family
H9L16_RS08495	COG4650	regulator
H9L16_RS08505	COG1690	Belongs to the RtcB family
H9L16_RS08510	COG0430	RNA-3'-phosphate cyclase activity
H9L16_RS08520	COG4772	TonB-dependent receptor
H9L16_RS08525	COG0514	ATP-dependent DNA helicase (RecQ)
H9L16_RS08530	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
H9L16_RS08535	COG4948	Mandelate Racemase Muconate Lactonizing
H9L16_RS08540	COG5505	Protein of unknown function (DUF819)
H9L16_RS08545	COG4771	TonB-dependent receptor
H9L16_RS08555	COG3949	Membrane
H9L16_RS08560	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
H9L16_RS08570	COG1643	Atp-dependent helicase
H9L16_RS08575	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
H9L16_RS08585	COG1216	Glycosyl transferase, family 2
H9L16_RS08585	COG0438	transferase activity, transferring glycosyl groups
H9L16_RS08590	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
H9L16_RS08595	COG1199	ATP-dependent helicase activity
H9L16_RS08615	COG0189	ligase activity
H9L16_RS08635	COG0840	transmembrane signaling receptor activity
H9L16_RS08640	COG2198	Histidine kinase
H9L16_RS08640	COG0784	Response regulator, receiver
H9L16_RS08640	COG0643	Histidine kinase
H9L16_RS08655	COG1385	rRNA (uridine-N3-)-methyltransferase activity
H9L16_RS08665	COG0494	nUDIX hydrolase
H9L16_RS08670	COG1218	3'(2'),5'-bisphosphate nucleotidase
H9L16_RS08675	COG3956	TIGRFAM MazG family protein
H9L16_RS08695	COG5002	protein histidine kinase activity
H9L16_RS08705	COG0577	efflux transmembrane transporter activity
H9L16_RS08705	COG1136	(ABC) transporter
H9L16_RS08710	COG0577	efflux transmembrane transporter activity
H9L16_RS08710	COG1136	(ABC) transporter
H9L16_RS08715	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
H9L16_RS08720	COG0861	Integral membrane protein TerC family
H9L16_RS08725	COG1704	LemA family
H9L16_RS08740	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
H9L16_RS08765	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
H9L16_RS08770	COG2967	ApaG domain
H9L16_RS08780	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
H9L16_RS08790	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
H9L16_RS08795	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H9L16_RS08800	COG0123	including yeast histone deacetylase and acetoin utilization protein
H9L16_RS08805	COG2096	Adenosyltransferase
H9L16_RS08815	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H9L16_RS08820	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H9L16_RS08825	COG0673	inositol 2-dehydrogenase activity
H9L16_RS08840	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H9L16_RS08865	COG0583	DNA-binding transcription factor activity
H9L16_RS08880	COG2890	protein-(glutamine-N5) methyltransferase activity
H9L16_RS08895	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
H9L16_RS08895	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
H9L16_RS08930	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
H9L16_RS08940	COG2151	metal-sulfur cluster biosynthetic enzyme
H9L16_RS08945	COG3227	Zinc metalloprotease (Elastase)
H9L16_RS08960	COG0252	asparaginase activity
H9L16_RS08965	COG0457	Tetratricopeptide repeat
H9L16_RS08980	COG1295	ribonuclease BN
H9L16_RS08985	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
H9L16_RS08990	COG1254	Belongs to the acylphosphatase family
H9L16_RS09010	COG0521	Mo-molybdopterin cofactor biosynthetic process
H9L16_RS09015	COG0456	acetyltransferase
H9L16_RS09020	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
H9L16_RS09025	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
H9L16_RS09040	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
H9L16_RS09050	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
H9L16_RS09085	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
H9L16_RS09095	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
H9L16_RS09100	COG0250	Participates in transcription elongation, termination and antitermination
H9L16_RS09105	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
H9L16_RS09120	COG0222	ribosome binding
H9L16_RS09130	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
H9L16_RS09140	COG0049	tRNA binding
H9L16_RS09145	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
H9L16_RS09150	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
H9L16_RS09160	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
H9L16_RS09165	COG0088	Forms part of the polypeptide exit tunnel
H9L16_RS09170	COG0089	rRNA binding
H9L16_RS09175	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
H9L16_RS09180	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
H9L16_RS09185	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
H9L16_RS09190	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
H9L16_RS09195	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
H9L16_RS09200	COG0255	Belongs to the universal ribosomal protein uL29 family
H9L16_RS09205	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
H9L16_RS09210	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
H9L16_RS09215	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
H9L16_RS09220	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
H9L16_RS09230	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
H9L16_RS09240	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
H9L16_RS09245	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
H9L16_RS09250	COG1841	ribosomal large subunit assembly
H9L16_RS09260	COG0201	protein transport
H9L16_RS09275	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
H9L16_RS09285	COG0203	ribosomal protein L17
H9L16_RS09295	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
H9L16_RS09315	COG1217	gtp-binding protein TYPA
H9L16_RS09320	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
H9L16_RS09330	COG0039	L-malate dehydrogenase activity
H9L16_RS09335	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
H9L16_RS09350	COG0446	pyridine nucleotide-disulphide oxidoreductase
H9L16_RS09350	COG1902	pentaerythritol trinitrate reductase activity
H9L16_RS09355	COG2885	chlorophyll binding
H9L16_RS09365	COG1187	pseudouridine synthase activity
H9L16_RS09370	COG0156	8-amino-7-oxononanoate synthase activity
H9L16_RS09395	COG0588	phosphoglycerate mutase activity
H9L16_RS09400	COG4989	oxidoreductase activity
H9L16_RS09405	COG0285	dihydrofolate synthase activity
H9L16_RS09420	COG2833	Protein of unknown function (DUF455)
H9L16_RS09430	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H9L16_RS09440	COG0735	belongs to the Fur family
H9L16_RS09465	COG1228	amidohydrolase
H9L16_RS09475	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
H9L16_RS09510	COG0477	Major facilitator Superfamily
H9L16_RS09530	COG3122	Protein conserved in bacteria
H9L16_RS09540	COG0477	Major facilitator Superfamily
H9L16_RS09620	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
H9L16_RS09625	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
H9L16_RS09640	COG0513	Belongs to the DEAD box helicase family
H9L16_RS09645	COG0534	Mate efflux family protein
H9L16_RS09720	COG3267	Type II secretory pathway component ExeA
H9L16_RS09720	COG3409	Peptidoglycan-binding domain 1 protein
H9L16_RS09740	COG0667	Aldo Keto reductase
H9L16_RS09795	COG4771	TonB-dependent receptor
H9L16_RS09835	COG1981	membrane
H9L16_RS09845	COG1301	dicarboxylic acid transport
H9L16_RS09860	COG0791	NLP P60 protein
H9L16_RS09865	COG0791	NLP P60 protein
H9L16_RS09875	COG2311	Membrane
H9L16_RS09880	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H9L16_RS09905	COG0837	glucose binding
H9L16_RS09910	COG1446	asparaginase
H9L16_RS09915	COG3142	Participates in the control of copper homeostasis
H9L16_RS09925	COG2877	3-deoxy-8-phosphooctulonate synthase activity
H9L16_RS09935	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
H9L16_RS09945	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
H9L16_RS09955	COG2840	Smr protein MutS2
H9L16_RS09960	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
H9L16_RS09970	COG3932	Exopolysaccharide synthesis, ExoD
H9L16_RS09985	COG1534	Rna-binding protein
H9L16_RS09990	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
H9L16_RS09995	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
H9L16_RS10000	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
H9L16_RS10010	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
H9L16_RS10015	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
H9L16_RS10020	COG1923	regulation of RNA biosynthetic process
H9L16_RS10025	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
H9L16_RS10030	COG0330	HflC and HflK could
H9L16_RS10035	COG0330	HflC and HflK could
H9L16_RS10045	COG0823	Involved in the tonB-independent uptake of proteins
H9L16_RS10045	COG1506	peptidase
H9L16_RS10075	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
H9L16_RS10075	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
H9L16_RS10080	COG2814	Major facilitator Superfamily
H9L16_RS10085	COG0531	amino acid
H9L16_RS10110	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
H9L16_RS10115	COG2894	cell division
H9L16_RS10120	COG0850	regulation of cytokinetic process
H9L16_RS10130	COG4585	Histidine kinase
H9L16_RS10135	COG2197	response regulator
H9L16_RS10160	COG3590	peptidase
H9L16_RS10170	COG0612	Peptidase, M16
H9L16_RS10185	COG3275	phosphorelay sensor kinase activity
H9L16_RS10195	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
H9L16_RS10220	COG0513	Belongs to the DEAD box helicase family
H9L16_RS10225	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
H9L16_RS10230	COG3321	synthase
H9L16_RS10230	COG0604	alcohol dehydrogenase
H9L16_RS10240	COG1960	acyl-CoA dehydrogenase activity
H9L16_RS10245	COG2045	Belongs to the ComB family
H9L16_RS10255	COG1250	3-hydroxyacyl-CoA dehydrogenase
H9L16_RS10255	COG1024	Enoyl-CoA hydratase
H9L16_RS10260	COG0183	Belongs to the thiolase family
H9L16_RS10265	COG1960	acyl-CoA dehydrogenase activity
H9L16_RS10280	COG1960	acyl-CoA dehydrogenase activity
H9L16_RS10285	COG1960	acyl-CoA dehydrogenase activity
H9L16_RS10300	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
H9L16_RS10315	COG4783	chaperone-mediated protein folding
H9L16_RS10330	COG0473	3-isopropylmalate dehydrogenase activity
H9L16_RS10365	COG0544	peptidyl-prolyl cis-trans isomerase activity
H9L16_RS10370	COG0740	serine-type endopeptidase activity
H9L16_RS10375	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
H9L16_RS10400	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H9L16_RS10430	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
H9L16_RS10440	COG1215	transferase activity, transferring glycosyl groups
H9L16_RS10520	COG1262	PFAM Formylglycine-generating sulfatase enzyme
H9L16_RS10525	COG0535	radical SAM domain protein
H9L16_RS10560	COG1216	Glycosyl transferase, family 2
H9L16_RS10585	COG0859	PFAM glycosyl transferase family 9
H9L16_RS10590	COG3642	lipopolysaccharide core region biosynthetic process
H9L16_RS10610	COG0314	molybdopterin synthase activity
H9L16_RS10625	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
H9L16_RS10630	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
H9L16_RS10640	COG0537	adenosine 5'-monophosphoramidase activity
H9L16_RS10665	COG0714	Associated with various cellular activities
H9L16_RS10685	COG1399	metal-binding, possibly nucleic acid-binding protein
H9L16_RS10690	COG0333	Belongs to the bacterial ribosomal protein bL32 family
H9L16_RS10695	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
H9L16_RS10705	COG1028	Short-chain dehydrogenase reductase Sdr
H9L16_RS10720	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
H9L16_RS10725	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
H9L16_RS10730	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
H9L16_RS10735	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
H9L16_RS10770	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H9L16_RS10775	COG0481	GTPase activity
H9L16_RS10780	COG0681	Belongs to the peptidase S26 family
H9L16_RS10795	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
H9L16_RS10800	COG1381	Involved in DNA repair and RecF pathway recombination
H9L16_RS10820	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
H9L16_RS10825	COG2954	triphosphatase activity
H9L16_RS10830	COG1472	Belongs to the glycosyl hydrolase 3 family
H9L16_RS10835	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
H9L16_RS10840	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
H9L16_RS10845	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H9L16_RS10850	COG1132	(ABC) transporter
H9L16_RS10860	COG1595	DNA-templated transcription, initiation
H9L16_RS10865	COG5001	Diguanylate cyclase
H9L16_RS10870	COG1012	belongs to the aldehyde dehydrogenase family
H9L16_RS10880	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
H9L16_RS10885	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
H9L16_RS10885	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
H9L16_RS10890	COG0671	phosphoesterase, PA-phosphatase related
H9L16_RS10910	COG0812	UDP-N-acetylmuramate dehydrogenase activity
H9L16_RS10925	COG1012	belongs to the aldehyde dehydrogenase family
H9L16_RS10935	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
H9L16_RS10960	COG1737	Transcriptional regulator
H9L16_RS10965	COG4948	Mandelate Racemase Muconate Lactonizing
H9L16_RS10985	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
H9L16_RS10995	COG2205	protein histidine kinase activity
H9L16_RS10995	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H9L16_RS11010	COG1262	PFAM Formylglycine-generating sulfatase enzyme
H9L16_RS11020	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
H9L16_RS11025	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
H9L16_RS11030	COG0084	hydrolase, TatD family'
H9L16_RS11045	COG1960	acyl-CoA dehydrogenase activity
H9L16_RS11060	COG0625	glutathione transferase activity
H9L16_RS11065	COG0022	dehydrogenase e1 component
H9L16_RS11070	COG0243	molybdopterin cofactor binding
H9L16_RS11095	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
H9L16_RS11100	COG1053	succinate dehydrogenase
H9L16_RS11105	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
H9L16_RS11120	COG4591	ABC-type transport system involved in lipoprotein release permease component
H9L16_RS11130	COG2333	competence protein COMEC
H9L16_RS11130	COG0658	competence protein
H9L16_RS11135	COG0811	peptide transport
H9L16_RS11145	COG1132	(ABC) transporter
H9L16_RS11150	COG1663	tetraacyldisaccharide 4'-kinase activity
H9L16_RS11160	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
H9L16_RS11165	COG0322	excinuclease ABC activity
H9L16_RS11170	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
H9L16_RS11190	COG0069	glutamate synthase activity
H9L16_RS11195	COG0175	sulfate reduction
H9L16_RS11200	COG0529	Catalyzes the synthesis of activated sulfate
H9L16_RS11200	COG2895	sulfate adenylyltransferase (ATP) activity
H9L16_RS11230	COG0489	protein tyrosine kinase activity
H9L16_RS11235	COG0484	heat shock protein binding
H9L16_RS11255	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
H9L16_RS11260	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H9L16_RS11300	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H9L16_RS11340	COG1215	transferase activity, transferring glycosyl groups
H9L16_RS11350	COG1216	Glycosyl transferase, family 2
H9L16_RS11385	COG0438	transferase activity, transferring glycosyl groups
H9L16_RS11400	COG0110	maltose O-acetyltransferase activity
H9L16_RS11410	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
H9L16_RS11415	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H9L16_RS11440	COG2264	protein methyltransferase activity
H9L16_RS11460	COG1132	(ABC) transporter
H9L16_RS11465	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
H9L16_RS11475	COG2199	diguanylate cyclase activity
H9L16_RS11475	COG2202	Pas domain
H9L16_RS11475	COG2200	EAL domain
H9L16_RS11500	COG4221	oxidoreductase activity
H9L16_RS11535	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
H9L16_RS11540	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
H9L16_RS11550	COG0077	Prephenate dehydratase
H9L16_RS11550	COG1605	Chorismate mutase
H9L16_RS11555	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
H9L16_RS11560	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
H9L16_RS11575	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
H9L16_RS11580	COG3594	Acyltransferase
H9L16_RS11600	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
H9L16_RS11605	COG0583	DNA-binding transcription factor activity
H9L16_RS11620	COG1530	ribonuclease E activity
H9L16_RS11635	COG2154	pterin-4-alpha-carbinolamine dehydratase
H9L16_RS11660	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
H9L16_RS11685	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
H9L16_RS11695	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
H9L16_RS11700	COG3241	Transfers electrons from cytochrome c551 to cytochrome oxidase
H9L16_RS11710	COG4133	protoheme IX ABC transporter activity
H9L16_RS11715	COG0436	Aminotransferase
H9L16_RS11785	COG3668	Plasmid stabilization system
H9L16_RS11800	COG3093	addiction module antidote protein HigA
H9L16_RS11855	COG3609	addiction module antidote protein, CC2985 family
H9L16_RS12090	COG1278	Cold shock
H9L16_RS12115	COG1742	UPF0060 membrane protein
H9L16_RS12310	COG3609	addiction module antidote protein, CC2985 family
H9L16_RS12360	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
H9L16_RS12370	COG2354	Protein conserved in bacteria
H9L16_RS12375	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
H9L16_RS12380	COG0745	RESPONSE REGULATOR receiver
H9L16_RS12385	COG2205	protein histidine kinase activity
H9L16_RS12390	COG4452	Inner membrane protein CreD
H9L16_RS12410	COG0671	phosphoesterase, PA-phosphatase related
H9L16_RS12415	COG0438	transferase activity, transferring glycosyl groups
H9L16_RS12420	COG1725	Transcriptional regulator
H9L16_RS12425	COG1131	(ABC) transporter
H9L16_RS12445	COG3706	GGDEF domain
H9L16_RS12470	COG1187	pseudouridine synthase activity
H9L16_RS12485	COG2350	Protein conserved in bacteria
H9L16_RS12500	COG3115	cell septum assembly
H9L16_RS12505	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
H9L16_RS12510	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
H9L16_RS12520	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
H9L16_RS12530	COG2373	Large extracellular alpha-helical protein
H9L16_RS12535	COG4953	penicillin-binding protein 1C
H9L16_RS12540	COG0678	peroxiredoxin activity
H9L16_RS12555	COG0604	alcohol dehydrogenase
H9L16_RS12575	COG0567	Dehydrogenase, E1 component
H9L16_RS12585	COG2850	peptidyl-arginine hydroxylation
H9L16_RS12625	COG1131	(ABC) transporter
H9L16_RS12630	COG1725	Transcriptional regulator
H9L16_RS12640	COG0545	Peptidyl-prolyl cis-trans isomerase
H9L16_RS12665	COG0287	Prephenate dehydrogenase
H9L16_RS12665	COG1605	Chorismate mutase
H9L16_RS12670	COG0646	methionine synthase
H9L16_RS12670	COG1410	methionine synthase
H9L16_RS12680	COG0640	Transcriptional regulator
H9L16_RS12685	COG1960	acyl-CoA dehydrogenase activity
H9L16_RS12690	COG2902	Dehydrogenase
H9L16_RS12700	COG5002	protein histidine kinase activity
H9L16_RS12700	COG5001	Diguanylate cyclase
H9L16_RS12725	COG2925	Exonuclease
H9L16_RS12730	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
H9L16_RS12735	COG3844	kynureninase activity
H9L16_RS12755	COG0288	reversible hydration of carbon dioxide
H9L16_RS12770	COG1028	Short-chain dehydrogenase reductase Sdr
H9L16_RS12790	COG0017	Asparaginyl-tRNA synthetase
H9L16_RS12795	COG0316	Belongs to the HesB IscA family
H9L16_RS12800	COG0360	Binds together with S18 to 16S ribosomal RNA
H9L16_RS12805	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
H9L16_RS12815	COG0305	Participates in initiation and elongation during chromosome replication
H9L16_RS12820	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
H9L16_RS12840	COG4251	negative regulation of phosphorylation
H9L16_RS12850	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
H9L16_RS12855	COG2867	negative regulation of translational initiation
H9L16_RS12865	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H9L16_RS12870	COG0735	belongs to the Fur family
H9L16_RS12875	COG0497	DNA recombination
H9L16_RS12880	COG1420	regulation of RNA biosynthetic process
H9L16_RS12885	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
H9L16_RS12890	COG0443	Heat shock 70 kDa protein
H9L16_RS12895	COG0484	heat shock protein binding
H9L16_RS12905	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
H9L16_RS12910	COG0505	Belongs to the CarA family
H9L16_RS12915	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
H9L16_RS12945	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
H9L16_RS12960	COG4676	Protein conserved in bacteria
H9L16_RS12985	COG1024	Enoyl-CoA hydratase
H9L16_RS12995	COG2205	protein histidine kinase activity
H9L16_RS12995	COG0784	Response regulator, receiver
H9L16_RS12995	COG2198	Histidine kinase
H9L16_RS13000	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H9L16_RS13005	COG0318	PFAM AMP-dependent synthetase and ligase
H9L16_RS13020	COG0659	secondary active sulfate transmembrane transporter activity
H9L16_RS13025	COG2199	diguanylate cyclase activity
H9L16_RS13025	COG2200	EAL domain
H9L16_RS13030	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
H9L16_RS13050	COG2915	High frequency lysogenization protein hflD homolog
H9L16_RS13055	COG0482	sulfurtransferase activity
H9L16_RS13065	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
H9L16_RS13070	COG0542	response to heat
H9L16_RS13080	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
H9L16_RS13090	COG0492	ferredoxin-NADP+ reductase activity
H9L16_RS13095	COG1674	ftsk spoiiie
H9L16_RS13110	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
H9L16_RS13115	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
H9L16_RS13120	COG3507	Belongs to the glycosyl hydrolase 43 family
H9L16_RS13125	COG3734	2-keto-3-deoxy-galactonokinase
H9L16_RS13140	COG0800	Aldolase
H9L16_RS13145	COG1028	Short-chain dehydrogenase reductase Sdr
H9L16_RS13175	COG1501	Belongs to the glycosyl hydrolase 31 family
H9L16_RS13185	COG1070	Carbohydrate kinase
H9L16_RS13195	COG0477	Major facilitator Superfamily
H9L16_RS13200	COG1472	Belongs to the glycosyl hydrolase 3 family
H9L16_RS13240	COG2132	Multicopper oxidase
H9L16_RS13260	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
H9L16_RS13265	COG1028	Short-chain dehydrogenase reductase Sdr
H9L16_RS13275	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
H9L16_RS13305	COG2986	histidine ammonia-lyase
H9L16_RS13330	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H9L16_RS13335	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H9L16_RS13365	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
H9L16_RS13375	COG3706	GGDEF domain
H9L16_RS13380	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
H9L16_RS13395	COG0519	Catalyzes the synthesis of GMP from XMP
H9L16_RS13395	COG0518	GMP synthase (glutamine-hydrolyzing) activity
H9L16_RS13425	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
H9L16_RS13430	COG0303	'Molybdopterin
H9L16_RS13435	COG0746	molybdenum cofactor guanylyltransferase activity
H9L16_RS13445	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H9L16_RS13465	COG0820	rRNA (adenine-C2-)-methyltransferase activity
H9L16_RS13470	COG0105	UTP biosynthetic process
H9L16_RS13480	COG1024	Enoyl-CoA hydratase
H9L16_RS13480	COG1250	3-hydroxyacyl-CoA dehydrogenase
H9L16_RS13485	COG0183	Belongs to the thiolase family
H9L16_RS13500	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
H9L16_RS13505	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
H9L16_RS13515	COG0776	regulation of translation
H9L16_RS13525	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
H9L16_RS13540	COG2957	Belongs to the agmatine deiminase family
H9L16_RS13545	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
H9L16_RS13570	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
H9L16_RS13580	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H9L16_RS13600	COG3243	poly(R)-hydroxyalkanoic acid synthase
H9L16_RS13610	COG1183	phosphatidylcholine synthase activity
H9L16_RS13620	COG1028	Short-chain dehydrogenase reductase Sdr
H9L16_RS13630	COG1064	alcohol dehydrogenase
H9L16_RS13640	COG2119	membrane
H9L16_RS13650	COG2205	protein histidine kinase activity
H9L16_RS13660	COG2610	gluconate transmembrane transporter activity
H9L16_RS13690	COG0477	Major facilitator Superfamily
H9L16_RS13695	COG2183	response to ionizing radiation
H9L16_RS13730	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
H9L16_RS13765	COG0195	Participates in both transcription termination and antitermination
H9L16_RS13770	COG0779	Required for maturation of 30S ribosomal subunits
H9L16_RS13780	COG1007	ATP synthesis coupled electron transport
H9L16_RS13795	COG0713	ATP synthesis coupled electron transport
H9L16_RS13815	COG1034	ATP synthesis coupled electron transport
H9L16_RS13825	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
H9L16_RS13830	COG0649	NAD binding
H9L16_RS13835	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H9L16_RS13845	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H9L16_RS13850	COG0488	(ABC) transporter
H9L16_RS13855	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
H9L16_RS13865	COG2081	HI0933 family
H9L16_RS13880	COG1834	amidinotransferase
H9L16_RS13905	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
H9L16_RS13910	COG3706	GGDEF domain
H9L16_RS13935	COG3706	GGDEF domain
H9L16_RS13980	COG0251	oxidation-reduction process
H9L16_RS13990	COG3590	peptidase
H9L16_RS14000	COG2409	Drug exporters of the RND superfamily
H9L16_RS14005	COG0204	Acyl-transferase
H9L16_RS14045	COG1619	proteins homologs of microcin C7 resistance protein MccF
H9L16_RS14080	COG1131	(ABC) transporter
H9L16_RS14085	COG4807	Protein conserved in bacteria
H9L16_RS14110	COG1901	pseudouridine methyltransferase
H9L16_RS14120	COG3214	Protein conserved in bacteria
H9L16_RS14170	COG3132	Protein of unknown function, DUF480
H9L16_RS14270	COG0189	ligase activity
H9L16_RS14330	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
H9L16_RS14330	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
H9L16_RS14330	COG1703	isobutyryl-CoA mutase activity
H9L16_RS14380	COG1960	acyl-CoA dehydrogenase activity
H9L16_RS14390	COG0183	Belongs to the thiolase family
H9L16_RS14405	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
H9L16_RS14435	COG1024	Enoyl-CoA hydratase
H9L16_RS14465	COG0456	acetyltransferase
H9L16_RS14480	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
H9L16_RS14490	COG0277	FAD linked oxidase domain protein
H9L16_RS14495	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
H9L16_RS14505	COG0531	amino acid
H9L16_RS14520	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
H9L16_RS14535	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
H9L16_RS14535	COG0140	phosphoribosyl-ATP diphosphatase activity
H9L16_RS14555	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
H9L16_RS14555	COG0131	Imidazoleglycerol-phosphate dehydratase
H9L16_RS14560	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
H9L16_RS14565	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
H9L16_RS14570	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
H9L16_RS14580	COG2986	histidine ammonia-lyase
H9L16_RS14585	COG0124	histidyl-tRNA synthetase
H9L16_RS14660	COG0582	viral genome integration into host DNA
H9L16_RS14665	COG2198	Histidine kinase
H9L16_RS14665	COG0784	Response regulator, receiver
H9L16_RS14665	COG5002	protein histidine kinase activity
H9L16_RS14670	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
H9L16_RS14670	COG4797	methyltransferase
H9L16_RS14775	COG4251	negative regulation of phosphorylation
H9L16_RS14810	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
H9L16_RS14815	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
H9L16_RS14820	COG0165	Argininosuccinate lyase
H9L16_RS14825	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
H9L16_RS14830	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
H9L16_RS14835	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H9L16_RS14845	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
H9L16_RS14860	COG2166	iron-sulfur cluster assembly
H9L16_RS14870	COG3237	CsbD-like
H9L16_RS14885	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
H9L16_RS14895	COG1469	GTP cyclohydrolase I activity
H9L16_RS14910	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
H9L16_RS14915	COG0402	S-adenosylhomocysteine deaminase activity
H9L16_RS14920	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
H9L16_RS14925	COG1509	lysine 2,3-aminomutase activity
H9L16_RS14945	COG1028	Short-chain dehydrogenase reductase Sdr
H9L16_RS14965	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
H9L16_RS14985	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
H9L16_RS14995	COG2133	pyrroloquinoline quinone binding
H9L16_RS15010	COG0386	Belongs to the glutathione peroxidase family
H9L16_RS15015	COG0339	signal peptide processing
H9L16_RS15020	COG1573	uracil-dna glycosylase
H9L16_RS15035	COG1793	dna ligase
H9L16_RS15040	COG1201	RNA secondary structure unwinding
H9L16_RS15050	COG1201	RNA secondary structure unwinding
H9L16_RS15065	COG1187	pseudouridine synthase activity
H9L16_RS15085	COG0625	glutathione transferase activity
H9L16_RS15140	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
H9L16_RS15165	COG0101	tRNA pseudouridine synthase activity
H9L16_RS15175	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
H9L16_RS15185	COG2890	protein-(glutamine-N5) methyltransferase activity
H9L16_RS15195	COG0688	phosphatidylethanolamine metabolic process
H9L16_RS15205	COG0433	COG0433 Predicted ATPase
H9L16_RS15210	COG3015	lipoprotein NlpE involved in copper resistance
H9L16_RS15215	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
H9L16_RS15230	COG0717	Belongs to the dCTP deaminase family
H9L16_RS15235	COG0489	protein tyrosine kinase activity
H9L16_RS15275	COG2878	Part of a membrane complex involved in electron transport
H9L16_RS15300	COG0802	atpase or kinase
H9L16_RS15305	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
H9L16_RS15305	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
H9L16_RS15310	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
H9L16_RS15320	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
H9L16_RS15325	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
H9L16_RS15330	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
H9L16_RS15335	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
H9L16_RS15340	COG0617	tRNA 3'-terminal CCA addition
H9L16_RS15350	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
H9L16_RS15360	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H9L16_RS15370	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
H9L16_RS15375	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
H9L16_RS15380	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
H9L16_RS15385	COG1181	Belongs to the D-alanine--D-alanine ligase family
H9L16_RS15385	COG2918	glutathione biosynthetic process
H9L16_RS15385	COG0189	ligase activity
H9L16_RS15400	COG0351	phosphomethylpyrimidine kinase
H9L16_RS15420	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
H9L16_RS15440	COG0800	Aldolase
H9L16_RS15450	COG1082	Xylose isomerase domain protein TIM barrel
H9L16_RS15460	COG0366	Alpha amylase catalytic
H9L16_RS15475	COG1609	Transcriptional regulator
H9L16_RS15490	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
H9L16_RS15495	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
H9L16_RS15500	COG2137	regulation of response to DNA damage stimulus
H9L16_RS15510	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
H9L16_RS15515	COG1546	Belongs to the CinA family
H9L16_RS15520	COG4771	TonB-dependent receptor
H9L16_RS15560	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
H9L16_RS15565	COG0228	four-way junction DNA binding
H9L16_RS15570	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
H9L16_RS15575	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
H9L16_RS15580	COG1846	Transcriptional regulator
H9L16_RS15590	COG1566	PFAM secretion protein HlyD family protein
H9L16_RS15595	COG2814	Major facilitator Superfamily
H9L16_RS15625	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
H9L16_RS15640	COG0196	riboflavin kinase activity
H9L16_RS15645	COG0728	peptidoglycan biosynthetic process
H9L16_RS15655	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
H9L16_RS15660	COG0211	Belongs to the bacterial ribosomal protein bL27 family
H9L16_RS15670	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
H9L16_RS15675	COG0824	Thioesterase
H9L16_RS15705	COG1024	Enoyl-CoA hydratase
H9L16_RS15715	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
H9L16_RS15750	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
H9L16_RS15760	COG0581	inorganic phosphate transmembrane transporter activity
H9L16_RS15770	COG0704	Plays a role in the regulation of phosphate uptake
H9L16_RS15780	COG3220	belongs to the UPF0276 family
H9L16_RS15810	COG3537	Alpha-1,2-mannosidase
H9L16_RS15815	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
H9L16_RS15830	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H9L16_RS15840	COG0557	exoribonuclease II activity
H9L16_RS15875	COG0415	Belongs to the DNA photolyase family
H9L16_RS15885	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
H9L16_RS15900	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
H9L16_RS15925	COG1595	DNA-templated transcription, initiation
H9L16_RS15945	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
H9L16_RS15960	COG0635	Involved in the biosynthesis of porphyrin-containing compound
H9L16_RS15965	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein