locus-tag	class	description
LIW09_RS00035	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
LIW09_RS00045	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
LIW09_RS00050	COG0471	metal ion transport
LIW09_RS00050	COG0490	domain, Protein
LIW09_RS00055	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
LIW09_RS00065	COG4591	ABC-type transport system involved in lipoprotein release permease component
LIW09_RS00070	COG1136	(ABC) transporter
LIW09_RS00075	COG5487	UPF0391 membrane protein
LIW09_RS00080	COG3186	Phenylalanine-4-hydroxylase
LIW09_RS00090	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
LIW09_RS00095	COG0302	gtp cyclohydrolase
LIW09_RS00100	COG1595	DNA-templated transcription, initiation
LIW09_RS00115	COG1752	Esterase of the alpha-beta hydrolase superfamily
LIW09_RS00130	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
LIW09_RS00180	COG0302	gtp cyclohydrolase
LIW09_RS00210	COG1446	asparaginase
LIW09_RS00270	COG0564	pseudouridine synthase activity
LIW09_RS00290	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
LIW09_RS00295	COG0318	PFAM AMP-dependent synthetase and ligase
LIW09_RS00305	COG0596	Alpha beta hydrolase
LIW09_RS00315	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
LIW09_RS00345	COG0714	Associated with various cellular activities
LIW09_RS00380	COG0823	Involved in the tonB-independent uptake of proteins
LIW09_RS00380	COG1506	peptidase
LIW09_RS00385	COG0625	glutathione transferase activity
LIW09_RS00390	COG0738	Major facilitator superfamily
LIW09_RS00395	COG0210	DNA helicase
LIW09_RS00400	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
LIW09_RS00410	COG1132	(ABC) transporter
LIW09_RS00425	COG2323	membrane
LIW09_RS00430	COG0408	coproporphyrinogen oxidase activity
LIW09_RS00435	COG0697	spore germination
LIW09_RS00465	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
LIW09_RS00470	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
LIW09_RS00485	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
LIW09_RS00495	COG0612	Peptidase, M16
LIW09_RS00505	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
LIW09_RS00515	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LIW09_RS00520	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
LIW09_RS00530	COG2815	serine threonine protein kinase
LIW09_RS00530	COG0515	serine threonine protein kinase
LIW09_RS00540	COG0210	DNA helicase
LIW09_RS00560	COG2937	Belongs to the GPAT DAPAT family
LIW09_RS00570	COG0037	tRNA processing
LIW09_RS00595	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
LIW09_RS00605	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
LIW09_RS00630	COG0519	Catalyzes the synthesis of GMP from XMP
LIW09_RS00630	COG0518	GMP synthase (glutamine-hydrolyzing) activity
LIW09_RS00635	COG0752	glycyl-tRNA synthetase alpha subunit
LIW09_RS00645	COG0729	surface antigen
LIW09_RS00675	COG0515	serine threonine protein kinase
LIW09_RS00695	COG3590	peptidase
LIW09_RS00715	COG1028	Short-chain dehydrogenase reductase Sdr
LIW09_RS00725	COG0616	signal peptide processing
LIW09_RS00730	COG0534	Mate efflux family protein
LIW09_RS00745	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
LIW09_RS00750	COG2860	membrane
LIW09_RS00760	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
LIW09_RS00765	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
LIW09_RS00780	COG2022	thiamine diphosphate biosynthetic process
LIW09_RS00795	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
LIW09_RS00805	COG2226	methyltransferase
LIW09_RS00810	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
LIW09_RS00825	COG3177	Filamentation induced by cAMP protein fic
LIW09_RS00830	COG0732	type I restriction modification DNA specificity domain
LIW09_RS00840	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
LIW09_RS00845	COG3118	belongs to the thioredoxin family
LIW09_RS00855	COG2884	Cell division ATP-binding protein ftsE
LIW09_RS00860	COG2177	Part of the ABC transporter FtsEX involved in
LIW09_RS00865	COG2201	protein-glutamate methylesterase activity
LIW09_RS00875	COG0308	aminopeptidase N
LIW09_RS00880	COG0596	Alpha beta hydrolase
LIW09_RS00880	COG0508	dehydrogenase complex catalyzes the overall conversion of
LIW09_RS00890	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LIW09_RS00895	COG1077	Cell shape determining protein MreB Mrl
LIW09_RS00915	COG0772	Belongs to the SEDS family
LIW09_RS00920	COG2951	lytic endotransglycosylase activity
LIW09_RS00925	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
LIW09_RS00930	COG1686	Belongs to the peptidase S11 family
LIW09_RS00935	COG2921	Belongs to the UPF0250 family
LIW09_RS00940	COG0321	lipoyl(octanoyl) transferase activity
LIW09_RS00950	COG0793	Belongs to the peptidase S41A family
LIW09_RS00955	COG0697	spore germination
LIW09_RS00965	COG0577	efflux transmembrane transporter activity
LIW09_RS00970	COG0577	efflux transmembrane transporter activity
LIW09_RS00975	COG1136	(ABC) transporter
LIW09_RS00980	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LIW09_RS00985	COG1131	(ABC) transporter
LIW09_RS00995	COG4585	Histidine kinase
LIW09_RS01000	COG2197	response regulator
LIW09_RS01015	COG0628	permease
LIW09_RS01035	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LIW09_RS01060	COG2234	aminopeptidase activity
LIW09_RS01070	COG3122	Protein conserved in bacteria
LIW09_RS01075	COG1451	nucleotide metabolic process
LIW09_RS01080	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
LIW09_RS01095	COG2824	Alkylphosphonate utilization operon protein PhnA
LIW09_RS01100	COG0686	Belongs to the AlaDH PNT family
LIW09_RS01105	COG1522	sequence-specific DNA binding
LIW09_RS01115	COG1028	Short-chain dehydrogenase reductase Sdr
LIW09_RS01125	COG2079	MmgE PrpD family protein
LIW09_RS01130	COG0038	chloride channel
LIW09_RS01140	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
LIW09_RS01170	COG1461	Dihydroxyacetone kinase
LIW09_RS01175	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
LIW09_RS01220	COG0180	Tryptophanyl-tRNA synthetase
LIW09_RS01225	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LIW09_RS01230	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LIW09_RS01250	COG0720	synthase
LIW09_RS01290	COG1002	Type II restriction enzyme, methylase subunits
LIW09_RS01310	COG1127	ABC transporter
LIW09_RS01315	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
LIW09_RS01330	COG0442	prolyl-tRNA aminoacylation
LIW09_RS01345	COG1183	phosphatidylcholine synthase activity
LIW09_RS01375	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
LIW09_RS01395	COG4974	Belongs to the 'phage' integrase family
LIW09_RS01400	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
LIW09_RS01405	COG0047	phosphoribosylformylglycinamidine synthase activity
LIW09_RS01405	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
LIW09_RS01410	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
LIW09_RS01415	COG1459	type II secretion system
LIW09_RS01420	COG2165	general secretion pathway protein
LIW09_RS01425	COG4970	Tfp pilus assembly protein FimT
LIW09_RS01430	COG2165	general secretion pathway protein
LIW09_RS01435	COG4795	General secretion pathway protein
LIW09_RS01440	COG3156	type II secretion system protein K
LIW09_RS01445	COG3166	PFAM Fimbrial assembly family protein
LIW09_RS01460	COG1450	Type ii and iii secretion system protein
LIW09_RS01480	COG0284	orotidine-5'-phosphate decarboxylase activity
LIW09_RS01485	COG0488	(ABC) transporter
LIW09_RS01500	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
LIW09_RS01510	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
LIW09_RS01510	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
LIW09_RS01525	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
LIW09_RS01530	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
LIW09_RS01540	COG0277	FAD linked oxidase domain protein
LIW09_RS01545	COG0792	nuclease activity
LIW09_RS01565	COG0463	Glycosyl transferase, family 2
LIW09_RS01575	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
LIW09_RS01595	COG2001	Belongs to the MraZ family
LIW09_RS01600	COG0275	rRNA processing
LIW09_RS01605	COG3116	cell division
LIW09_RS01620	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
LIW09_RS01625	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
LIW09_RS01640	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
LIW09_RS01645	COG1181	Belongs to the D-alanine--D-alanine ligase family
LIW09_RS01650	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
LIW09_RS01675	COG0739	heme binding
LIW09_RS01680	COG0653	protein targeting
LIW09_RS01695	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
LIW09_RS01715	COG3550	peptidyl-serine autophosphorylation
LIW09_RS01745	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
LIW09_RS01750	COG2755	lipolytic protein G-D-S-L family
LIW09_RS01750	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
LIW09_RS01770	COG3588	fructose-bisphosphate aldolase
LIW09_RS01785	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LIW09_RS01790	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
LIW09_RS01800	COG1970	mechanosensitive ion channel activity
LIW09_RS01820	COG0471	metal ion transport
LIW09_RS01820	COG3273	potassium ion transport
LIW09_RS01825	COG0220	tRNA (guanine-N7-)-methyltransferase activity
LIW09_RS01840	COG0189	ligase activity
LIW09_RS01845	COG0745	RESPONSE REGULATOR receiver
LIW09_RS01855	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
LIW09_RS01865	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
LIW09_RS01875	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
LIW09_RS01880	COG0488	(ABC) transporter
LIW09_RS01910	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
LIW09_RS01920	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
LIW09_RS01925	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LIW09_RS01930	COG2211	Major facilitator Superfamily
LIW09_RS01935	COG3706	GGDEF domain
LIW09_RS01940	COG0330	HflC and HflK could
LIW09_RS01950	COG0404	The glycine cleavage system catalyzes the degradation of glycine
LIW09_RS01975	COG1704	LemA family
LIW09_RS01980	COG0501	Belongs to the peptidase M48B family
LIW09_RS01995	COG1960	acyl-CoA dehydrogenase activity
LIW09_RS02000	COG1309	transcriptional regulator
LIW09_RS02005	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
LIW09_RS02045	COG0463	Glycosyl transferase, family 2
LIW09_RS02055	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
LIW09_RS02060	COG0515	serine threonine protein kinase
LIW09_RS02070	COG0739	heme binding
LIW09_RS02075	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
LIW09_RS02080	COG0626	cystathionine gamma-synthase activity
LIW09_RS02090	COG5002	protein histidine kinase activity
LIW09_RS02090	COG5001	Diguanylate cyclase
LIW09_RS02095	COG3706	GGDEF domain
LIW09_RS02100	COG1760	l-serine dehydratase
LIW09_RS02115	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
LIW09_RS02140	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
LIW09_RS02150	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
LIW09_RS02165	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
LIW09_RS02180	COG1678	Uncharacterized ACR, COG1678
LIW09_RS02185	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
LIW09_RS02190	COG0540	Belongs to the ATCase OTCase family
LIW09_RS02195	COG0393	Putative heavy-metal-binding
LIW09_RS02200	COG2239	Acts as a magnesium transporter
LIW09_RS02210	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
LIW09_RS02215	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
LIW09_RS02225	COG1660	Displays ATPase and GTPase activities
LIW09_RS02240	COG1137	ATPase activity
LIW09_RS02255	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
LIW09_RS02265	COG0271	Belongs to the BolA IbaG family
LIW09_RS02300	COG0583	DNA-binding transcription factor activity
LIW09_RS02330	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
LIW09_RS02330	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
LIW09_RS02365	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
LIW09_RS02395	COG0457	Tetratricopeptide repeat
LIW09_RS02410	COG1295	ribonuclease BN
LIW09_RS02415	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LIW09_RS02440	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
LIW09_RS02445	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
LIW09_RS02460	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
LIW09_RS02470	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
LIW09_RS02480	COG0193	aminoacyl-tRNA hydrolase activity
LIW09_RS02485	COG0012	GTP binding
LIW09_RS02505	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
LIW09_RS02515	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
LIW09_RS02520	COG0250	Participates in transcription elongation, termination and antitermination
LIW09_RS02525	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
LIW09_RS02535	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
LIW09_RS02540	COG0222	ribosome binding
LIW09_RS02550	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
LIW09_RS02555	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
LIW09_RS02560	COG0049	tRNA binding
LIW09_RS02565	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
LIW09_RS02570	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
LIW09_RS02575	COG0051	transcription antitermination factor activity, RNA binding
LIW09_RS02580	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
LIW09_RS02590	COG0089	rRNA binding
LIW09_RS02595	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
LIW09_RS02600	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
LIW09_RS02605	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
LIW09_RS02615	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
LIW09_RS02620	COG0255	Belongs to the universal ribosomal protein uL29 family
LIW09_RS02625	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
LIW09_RS02635	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
LIW09_RS02640	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
LIW09_RS02645	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
LIW09_RS02650	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
LIW09_RS02655	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
LIW09_RS02670	COG1841	ribosomal large subunit assembly
LIW09_RS02680	COG0201	protein transport
LIW09_RS02690	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
LIW09_RS02695	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
LIW09_RS02705	COG0203	ribosomal protein L17
LIW09_RS02710	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
LIW09_RS02715	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
LIW09_RS02720	COG0154	amidase activity
LIW09_RS02730	COG1217	gtp-binding protein TYPA
LIW09_RS02735	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
LIW09_RS02760	COG0039	L-malate dehydrogenase activity
LIW09_RS02785	COG0625	glutathione transferase activity
LIW09_RS02795	COG1902	pentaerythritol trinitrate reductase activity
LIW09_RS02795	COG0446	pyridine nucleotide-disulphide oxidoreductase
LIW09_RS02810	COG1187	pseudouridine synthase activity
LIW09_RS02815	COG0156	8-amino-7-oxononanoate synthase activity
LIW09_RS02825	COG1063	alcohol dehydrogenase
LIW09_RS02840	COG0406	alpha-ribazole phosphatase activity
LIW09_RS02845	COG0285	dihydrofolate synthase activity
LIW09_RS02860	COG2833	Protein of unknown function (DUF455)
LIW09_RS02865	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
LIW09_RS02875	COG0735	belongs to the Fur family
LIW09_RS02880	COG3746	phosphate-selective porin O and P
LIW09_RS02910	COG1228	amidohydrolase
LIW09_RS02915	COG0010	Belongs to the arginase family
LIW09_RS02930	COG3039	Transposase
LIW09_RS03080	COG0456	acetyltransferase
LIW09_RS03175	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
LIW09_RS03185	COG2354	Protein conserved in bacteria
LIW09_RS03190	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
LIW09_RS03195	COG0745	RESPONSE REGULATOR receiver
LIW09_RS03200	COG2205	protein histidine kinase activity
LIW09_RS03205	COG4452	Inner membrane protein CreD
LIW09_RS03225	COG5002	protein histidine kinase activity
LIW09_RS03230	COG0745	RESPONSE REGULATOR receiver
LIW09_RS03235	COG4783	chaperone-mediated protein folding
LIW09_RS03245	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
LIW09_RS03250	COG0473	3-isopropylmalate dehydrogenase activity
LIW09_RS03270	COG0741	lytic transglycosylase activity
LIW09_RS03270	COG0791	NLP P60 protein
LIW09_RS03275	COG0791	NLP P60 protein
LIW09_RS03305	COG2877	3-deoxy-8-phosphooctulonate synthase activity
LIW09_RS03310	COG0148	phosphopyruvate hydratase activity
LIW09_RS03315	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
LIW09_RS03325	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
LIW09_RS03340	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
LIW09_RS03365	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
LIW09_RS03370	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
LIW09_RS03380	COG0628	permease
LIW09_RS03385	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
LIW09_RS03390	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
LIW09_RS03395	COG3178	'Phosphotransferase
LIW09_RS03410	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
LIW09_RS03410	COG1648	precorrin-2 dehydrogenase activity
LIW09_RS03425	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
LIW09_RS03430	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
LIW09_RS03450	COG0424	maF-like protein
LIW09_RS03465	COG0312	modulator of DNA gyrase
LIW09_RS03475	COG0312	modulator of DNA gyrase
LIW09_RS03510	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
LIW09_RS03515	COG0719	Fe-S assembly protein
LIW09_RS03520	COG0396	ATPase activity
LIW09_RS03525	COG0719	Fe-S assembly protein
LIW09_RS03535	COG0657	acetylesterase activity
LIW09_RS03575	COG0457	Tetratricopeptide repeat
LIW09_RS03580	COG4771	TonB-dependent receptor
LIW09_RS03600	COG1981	membrane
LIW09_RS03610	COG2226	methyltransferase
LIW09_RS03630	COG0789	Transcriptional regulator
LIW09_RS03645	COG0557	exoribonuclease II activity
LIW09_RS03650	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
LIW09_RS03660	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
LIW09_RS03680	COG0704	Plays a role in the regulation of phosphate uptake
LIW09_RS03685	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
LIW09_RS03690	COG0581	inorganic phosphate transmembrane transporter activity
LIW09_RS03695	COG0573	inorganic phosphate transmembrane transporter activity
LIW09_RS03700	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
LIW09_RS03705	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
LIW09_RS03715	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
LIW09_RS03725	COG1024	Enoyl-CoA hydratase
LIW09_RS03745	COG1393	Belongs to the ArsC family
LIW09_RS03750	COG1024	Enoyl-CoA hydratase
LIW09_RS03750	COG1250	3-hydroxyacyl-CoA dehydrogenase
LIW09_RS03755	COG0824	Thioesterase
LIW09_RS03765	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
LIW09_RS03770	COG1074	ATP-dependent DNA helicase activity
LIW09_RS03775	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
LIW09_RS03830	COG1518	maintenance of DNA repeat elements
LIW09_RS03865	COG1337	RAMP superfamily
LIW09_RS03920	COG2119	membrane
LIW09_RS03935	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
LIW09_RS03945	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
LIW09_RS04005	COG1073	alpha beta
LIW09_RS04035	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
LIW09_RS04050	COG1946	Acyl-CoA thioesterase
LIW09_RS04070	COG1177	transmembrane transport
LIW09_RS04075	COG1176	ABC-type spermidine putrescine transport system, permease component I
LIW09_RS04080	COG3842	ATPase activity
LIW09_RS04085	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
LIW09_RS04100	COG1960	acyl-CoA dehydrogenase activity
LIW09_RS04125	COG4774	siderophore transport
LIW09_RS04135	COG3590	peptidase
LIW09_RS04150	COG0612	Peptidase, M16
LIW09_RS04155	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
LIW09_RS04160	COG0513	Belongs to the DEAD box helicase family
LIW09_RS04170	COG4783	chaperone-mediated protein folding
LIW09_RS04180	COG0142	geranyltranstransferase activity
LIW09_RS04185	COG1722	exodeoxyribonuclease VII activity
LIW09_RS04190	COG0037	tRNA processing
LIW09_RS04200	COG0825	malonyl-CoA metabolic process
LIW09_RS04215	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
LIW09_RS04225	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
LIW09_RS04230	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
LIW09_RS04240	COG0750	zinc metalloprotease
LIW09_RS04245	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
LIW09_RS04250	COG0575	Belongs to the CDS family
LIW09_RS04255	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
LIW09_RS04270	COG3706	GGDEF domain
LIW09_RS04285	COG0024	Methionine aminopeptidase
LIW09_RS04305	COG1393	Belongs to the ArsC family
LIW09_RS04310	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
LIW09_RS04320	COG0367	asparagine synthase
LIW09_RS04330	COG2197	response regulator
LIW09_RS04370	COG2010	Cytochrome c
LIW09_RS04385	COG3278	Belongs to the heme-copper respiratory oxidase family
LIW09_RS04390	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
LIW09_RS04440	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
LIW09_RS04470	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
LIW09_RS04475	COG0635	Involved in the biosynthesis of porphyrin-containing compound
LIW09_RS04480	COG0500	methyltransferase
LIW09_RS04490	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
LIW09_RS04495	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
LIW09_RS04495	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
LIW09_RS04500	COG0802	atpase or kinase
LIW09_RS04505	COG0860	N-Acetylmuramoyl-L-alanine amidase
LIW09_RS04525	COG2878	Part of a membrane complex involved in electron transport
LIW09_RS04530	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LIW09_RS04530	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LIW09_RS04540	COG0457	Tetratricopeptide repeat
LIW09_RS04545	COG4771	TonB-dependent receptor
LIW09_RS04550	COG0489	protein tyrosine kinase activity
LIW09_RS04555	COG0717	Belongs to the dCTP deaminase family
LIW09_RS04615	COG4771	TonB-dependent receptor
LIW09_RS04620	COG1546	Belongs to the CinA family
LIW09_RS04625	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
LIW09_RS04630	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
LIW09_RS04635	COG2137	regulation of response to DNA damage stimulus
LIW09_RS04650	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
LIW09_RS04655	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
LIW09_RS04685	COG0183	Belongs to the thiolase family
LIW09_RS04695	COG1960	acyl-CoA dehydrogenase activity
LIW09_RS04715	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
LIW09_RS04715	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
LIW09_RS04715	COG1703	isobutyryl-CoA mutase activity
LIW09_RS04730	COG1131	(ABC) transporter
LIW09_RS04785	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
LIW09_RS04790	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
LIW09_RS04795	COG2954	triphosphatase activity
LIW09_RS04800	COG1472	Belongs to the glycosyl hydrolase 3 family
LIW09_RS04805	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
LIW09_RS04810	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
LIW09_RS04815	COG1278	Cold shock
LIW09_RS04820	COG1609	Transcriptional regulator
LIW09_RS04835	COG0366	Alpha amylase catalytic
LIW09_RS04840	COG1082	Xylose isomerase domain protein TIM barrel
LIW09_RS04850	COG0800	Aldolase
LIW09_RS04870	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
LIW09_RS04890	COG0659	secondary active sulfate transmembrane transporter activity
LIW09_RS04895	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
LIW09_RS04900	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
LIW09_RS04910	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
LIW09_RS04920	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
LIW09_RS04930	COG0617	tRNA 3'-terminal CCA addition
LIW09_RS04935	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
LIW09_RS04940	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
LIW09_RS04945	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
LIW09_RS04950	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
LIW09_RS04955	COG0166	Belongs to the GPI family
LIW09_RS04975	COG1132	(ABC) transporter
LIW09_RS04985	COG1595	DNA-templated transcription, initiation
LIW09_RS05005	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
LIW09_RS05010	COG5002	protein histidine kinase activity
LIW09_RS05010	COG5001	Diguanylate cyclase
LIW09_RS05010	COG3447	MASE1 domain protein
LIW09_RS05020	COG0812	UDP-N-acetylmuramate dehydrogenase activity
LIW09_RS05025	COG0167	dihydroorotate dehydrogenase activity
LIW09_RS05035	COG1012	belongs to the aldehyde dehydrogenase family
LIW09_RS05045	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
LIW09_RS05055	COG0460	homoserine dehydrogenase
LIW09_RS05055	COG0527	aspartate kinase activity
LIW09_RS05065	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
LIW09_RS05085	COG2814	Major facilitator Superfamily
LIW09_RS05090	COG1566	PFAM secretion protein HlyD family protein
LIW09_RS05100	COG1846	Transcriptional regulator
LIW09_RS05105	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
LIW09_RS05120	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
LIW09_RS05125	COG0521	Mo-molybdopterin cofactor biosynthetic process
LIW09_RS05125	COG0315	cyclic pyranopterin monophosphate synthase activity
LIW09_RS05130	COG0303	'Molybdopterin
LIW09_RS05140	COG0314	molybdopterin synthase activity
LIW09_RS05150	COG2223	nitrite transmembrane transporter activity
LIW09_RS05155	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
LIW09_RS05160	COG1140	nitrate reductase beta subunit
LIW09_RS05165	COG1140	nitrate reductase beta subunit
LIW09_RS05170	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
LIW09_RS05175	COG2181	nitrate reductase activity
LIW09_RS05180	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
LIW09_RS05195	COG4772	TonB-dependent receptor
LIW09_RS05210	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
LIW09_RS05225	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
LIW09_RS05230	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
LIW09_RS05240	COG0228	four-way junction DNA binding
LIW09_RS05245	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
LIW09_RS05250	COG0336	Belongs to the RNA methyltransferase TrmD family
LIW09_RS05265	COG3409	Peptidoglycan-binding domain 1 protein
LIW09_RS05265	COG3773	Cell wall hydrolase
LIW09_RS05270	COG1522	sequence-specific DNA binding
LIW09_RS05275	COG0626	cystathionine gamma-synthase activity
LIW09_RS05280	COG2258	MOSC domain
LIW09_RS05310	COG0028	Belongs to the TPP enzyme family
LIW09_RS05320	COG5001	Diguanylate cyclase
LIW09_RS05340	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
LIW09_RS05365	COG4591	ABC-type transport system involved in lipoprotein release permease component
LIW09_RS05375	COG2333	competence protein COMEC
LIW09_RS05375	COG0658	competence protein
LIW09_RS05395	COG1663	tetraacyldisaccharide 4'-kinase activity
LIW09_RS05400	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
LIW09_RS05405	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
LIW09_RS05410	COG0322	excinuclease ABC activity
LIW09_RS05415	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
LIW09_RS05435	COG0069	glutamate synthase activity
LIW09_RS05445	COG2895	sulfate adenylyltransferase (ATP) activity
LIW09_RS05445	COG0529	Catalyzes the synthesis of activated sulfate
LIW09_RS05450	COG5001	Diguanylate cyclase
LIW09_RS05450	COG3300	MHYT domain
LIW09_RS05470	COG0484	heat shock protein binding
LIW09_RS05495	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
LIW09_RS05505	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
LIW09_RS05540	COG0297	glycogen (starch) synthase activity
LIW09_RS05540	COG0438	transferase activity, transferring glycosyl groups
LIW09_RS05545	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
LIW09_RS05590	COG0367	asparagine synthase
LIW09_RS05595	COG1132	(ABC) transporter
LIW09_RS05625	COG4221	oxidoreductase activity
LIW09_RS05670	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
LIW09_RS05675	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
LIW09_RS05680	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LIW09_RS05710	COG1420	regulation of RNA biosynthetic process
LIW09_RS05720	COG0443	Heat shock 70 kDa protein
LIW09_RS05740	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
LIW09_RS05745	COG0505	Belongs to the CarA family
LIW09_RS05750	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
LIW09_RS05755	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
LIW09_RS05765	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
LIW09_RS05805	COG1024	Enoyl-CoA hydratase
LIW09_RS05810	COG0318	PFAM AMP-dependent synthetase and ligase
LIW09_RS05815	COG0183	Belongs to the thiolase family
LIW09_RS05820	COG1024	Enoyl-CoA hydratase
LIW09_RS05820	COG1250	3-hydroxyacyl-CoA dehydrogenase
LIW09_RS05835	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
LIW09_RS05840	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
LIW09_RS05855	COG0105	UTP biosynthetic process
LIW09_RS05880	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
LIW09_RS05885	COG1160	GTP binding
LIW09_RS05890	COG0746	molybdenum cofactor guanylyltransferase activity
LIW09_RS05895	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
LIW09_RS05910	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
LIW09_RS05920	COG0518	GMP synthase (glutamine-hydrolyzing) activity
LIW09_RS05920	COG0519	Catalyzes the synthesis of GMP from XMP
LIW09_RS05940	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
LIW09_RS05945	COG3292	Two component regulator propeller
LIW09_RS05945	COG2205	protein histidine kinase activity
LIW09_RS05945	COG0745	RESPONSE REGULATOR receiver
LIW09_RS05960	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LIW09_RS05965	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LIW09_RS05980	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
LIW09_RS05980	COG0574	Belongs to the PEP-utilizing enzyme family
LIW09_RS05985	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
LIW09_RS06005	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
LIW09_RS06010	COG2867	negative regulation of translational initiation
LIW09_RS06020	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
LIW09_RS06040	COG0789	Transcriptional regulator
LIW09_RS06070	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
LIW09_RS06090	COG1595	DNA-templated transcription, initiation
LIW09_RS06100	COG0302	gtp cyclohydrolase
LIW09_RS06105	COG3040	lipid binding
LIW09_RS06115	COG0415	Belongs to the DNA photolyase family
LIW09_RS06160	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
LIW09_RS06175	COG3586	endonuclease activity
LIW09_RS06190	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
LIW09_RS06205	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
LIW09_RS06210	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
LIW09_RS06220	COG0754	glutathionylspermidine amidase activity
LIW09_RS06260	COG1960	acyl-CoA dehydrogenase activity
LIW09_RS06265	COG0672	)-iron permease
LIW09_RS06295	COG0835	chemotaxis
LIW09_RS06295	COG0784	Response regulator, receiver
LIW09_RS06300	COG1815	bacterial-type flagellum-dependent cell motility
LIW09_RS06320	COG4786	Flagellar basal body rod
LIW09_RS06325	COG4786	Flagellar basal body rod
LIW09_RS06330	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
LIW09_RS06340	COG3951	Flagellar rod assembly protein muramidase FlgJ
LIW09_RS06340	COG1705	Flagellar rod assembly protein muramidase FlgJ
LIW09_RS06380	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
LIW09_RS06385	COG1516	flagellar protein fliS
LIW09_RS06405	COG2201	protein-glutamate methylesterase activity
LIW09_RS06415	COG1677	Flagellar hook-basal body complex protein FliE
LIW09_RS06475	COG1987	bacterial-type flagellum assembly
LIW09_RS06480	COG1684	flagellar biosynthetic protein fliR
LIW09_RS06490	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
LIW09_RS06515	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
LIW09_RS06520	COG0643	Histidine kinase
LIW09_RS06520	COG0784	Response regulator, receiver
LIW09_RS06520	COG2198	Histidine kinase
LIW09_RS06525	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
LIW09_RS06530	COG1360	Flagellar Motor Protein
LIW09_RS06535	COG1192	Involved in chromosome partitioning
LIW09_RS06540	COG0835	chemotaxis
LIW09_RS06555	COG0643	Histidine kinase
LIW09_RS06555	COG2198	Histidine kinase
LIW09_RS06560	COG0835	chemotaxis
LIW09_RS06575	COG0840	transmembrane signaling receptor activity
LIW09_RS06580	COG3300	MHYT domain
LIW09_RS06580	COG5001	Diguanylate cyclase
LIW09_RS06590	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
LIW09_RS06605	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
LIW09_RS06610	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
LIW09_RS06620	COG1674	ftsk spoiiie
LIW09_RS06625	COG0492	ferredoxin-NADP+ reductase activity
LIW09_RS06665	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LIW09_RS06690	COG3243	poly(R)-hydroxyalkanoic acid synthase
LIW09_RS06700	COG1183	phosphatidylcholine synthase activity
LIW09_RS06710	COG1028	Short-chain dehydrogenase reductase Sdr
LIW09_RS06720	COG1064	alcohol dehydrogenase
LIW09_RS06725	COG0784	Response regulator, receiver
LIW09_RS06725	COG2198	Histidine kinase
LIW09_RS06725	COG2205	protein histidine kinase activity
LIW09_RS06730	COG4771	TonB-dependent receptor
LIW09_RS06735	COG2610	gluconate transmembrane transporter activity
LIW09_RS06740	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
LIW09_RS06750	COG0477	Major facilitator Superfamily
LIW09_RS06755	COG2183	response to ionizing radiation
LIW09_RS06770	COG0542	response to heat
LIW09_RS06775	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
LIW09_RS06785	COG0482	sulfurtransferase activity
LIW09_RS06790	COG2915	High frequency lysogenization protein hflD homolog
LIW09_RS06810	COG3706	GGDEF domain
LIW09_RS06820	COG1210	Utp--glucose-1-phosphate uridylyltransferase
LIW09_RS06830	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
LIW09_RS06840	COG0776	regulation of translation
LIW09_RS06850	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
LIW09_RS06855	COG0257	Belongs to the bacterial ribosomal protein bL36 family
LIW09_RS06865	COG2957	Belongs to the agmatine deiminase family
LIW09_RS06870	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
LIW09_RS06895	COG5001	Diguanylate cyclase
LIW09_RS06895	COG5002	protein histidine kinase activity
LIW09_RS06910	COG3550	peptidyl-serine autophosphorylation
LIW09_RS06915	COG1396	sequence-specific DNA binding
LIW09_RS06920	COG2814	Major facilitator Superfamily
LIW09_RS06965	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
LIW09_RS06970	COG0305	Participates in initiation and elongation during chromosome replication
LIW09_RS06975	COG0359	binds to the 23S rRNA
LIW09_RS06980	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
LIW09_RS06985	COG0360	Binds together with S18 to 16S ribosomal RNA
LIW09_RS06990	COG0316	Belongs to the HesB IscA family
LIW09_RS06995	COG0017	Asparaginyl-tRNA synthetase
LIW09_RS07015	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
LIW09_RS07015	COG0316	Belongs to the HesB IscA family
LIW09_RS07025	COG0564	pseudouridine synthase activity
LIW09_RS07030	COG1530	ribonuclease E activity
LIW09_RS07035	COG2197	response regulator
LIW09_RS07045	COG3033	Beta-eliminating lyase
LIW09_RS07050	COG1522	sequence-specific DNA binding
LIW09_RS07060	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
LIW09_RS07070	COG2925	Exonuclease
LIW09_RS07085	COG5002	protein histidine kinase activity
LIW09_RS07085	COG5001	Diguanylate cyclase
LIW09_RS07095	COG2902	Dehydrogenase
LIW09_RS07100	COG1960	acyl-CoA dehydrogenase activity
LIW09_RS07115	COG0646	methionine synthase
LIW09_RS07115	COG1410	methionine synthase
LIW09_RS07125	COG2900	Belongs to the SlyX family
LIW09_RS07140	COG0545	Peptidyl-prolyl cis-trans isomerase
LIW09_RS07150	COG1725	Transcriptional regulator
LIW09_RS07155	COG1131	(ABC) transporter
LIW09_RS07180	COG2850	peptidyl-arginine hydroxylation
LIW09_RS07190	COG0567	Dehydrogenase, E1 component
LIW09_RS07210	COG0604	alcohol dehydrogenase
LIW09_RS07225	COG0678	peroxiredoxin activity
LIW09_RS07230	COG4953	penicillin-binding protein 1C
LIW09_RS07250	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
LIW09_RS07260	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
LIW09_RS07265	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
LIW09_RS07285	COG2350	Protein conserved in bacteria
LIW09_RS07300	COG1187	pseudouridine synthase activity
LIW09_RS07350	COG0436	Aminotransferase
LIW09_RS07390	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LIW09_RS07405	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
LIW09_RS07415	COG1028	Short-chain dehydrogenase reductase Sdr
LIW09_RS07430	COG0288	reversible hydration of carbon dioxide
LIW09_RS07450	COG1185	polyribonucleotide nucleotidyltransferase activity
LIW09_RS07455	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
LIW09_RS07475	COG0195	Participates in both transcription termination and antitermination
LIW09_RS07480	COG0779	Required for maturation of 30S ribosomal subunits
LIW09_RS07490	COG1007	ATP synthesis coupled electron transport
LIW09_RS07535	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
LIW09_RS07540	COG0649	NAD binding
LIW09_RS07545	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LIW09_RS07555	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LIW09_RS07565	COG2081	HI0933 family
LIW09_RS07580	COG1834	amidinotransferase
LIW09_RS07600	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
LIW09_RS07610	COG3590	peptidase
LIW09_RS07645	COG3038	cytochrome b561
LIW09_RS07650	COG0204	Acyl-transferase
LIW09_RS07680	COG0813	purine-nucleoside phosphorylase activity
LIW09_RS07685	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
LIW09_RS07690	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
LIW09_RS07740	COG1918	ferrous iron import across plasma membrane
LIW09_RS07740	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
LIW09_RS07750	COG1024	Enoyl-CoA hydratase
LIW09_RS07770	COG0456	acetyltransferase
LIW09_RS07785	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
LIW09_RS07810	COG0277	FAD linked oxidase domain protein
LIW09_RS07815	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
LIW09_RS07825	COG0531	amino acid
LIW09_RS07830	COG0235	Class ii aldolase
LIW09_RS07835	COG0235	Class ii aldolase
LIW09_RS07840	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
LIW09_RS07845	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
LIW09_RS07855	COG3706	GGDEF domain
LIW09_RS07860	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
LIW09_RS07860	COG0140	phosphoribosyl-ATP diphosphatase activity
LIW09_RS07875	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
LIW09_RS07885	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
LIW09_RS07895	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
LIW09_RS07905	COG2986	histidine ammonia-lyase
LIW09_RS07910	COG0124	histidyl-tRNA synthetase
LIW09_RS07980	COG0582	viral genome integration into host DNA
LIW09_RS07985	COG0784	Response regulator, receiver
LIW09_RS07985	COG5002	protein histidine kinase activity
LIW09_RS07985	COG2198	Histidine kinase
LIW09_RS07990	COG1309	transcriptional regulator
LIW09_RS08005	COG1136	(ABC) transporter
LIW09_RS08135	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
LIW09_RS08140	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
LIW09_RS08145	COG0165	Argininosuccinate lyase
LIW09_RS08150	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
LIW09_RS08155	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
LIW09_RS08160	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
LIW09_RS08165	COG0137	argininosuccinate synthase activity
LIW09_RS08170	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
LIW09_RS08185	COG2166	iron-sulfur cluster assembly
LIW09_RS08205	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
LIW09_RS08210	COG1469	GTP cyclohydrolase I activity
LIW09_RS08225	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
LIW09_RS08230	COG0402	S-adenosylhomocysteine deaminase activity
LIW09_RS08240	COG1509	lysine 2,3-aminomutase activity
LIW09_RS08250	COG0501	Belongs to the peptidase M48B family
LIW09_RS08260	COG1028	Short-chain dehydrogenase reductase Sdr
LIW09_RS08305	COG0386	Belongs to the glutathione peroxidase family
LIW09_RS08310	COG0339	signal peptide processing
LIW09_RS08325	COG1187	pseudouridine synthase activity
LIW09_RS08330	COG3275	phosphorelay sensor kinase activity
LIW09_RS08335	COG1611	Belongs to the LOG family
LIW09_RS08345	COG2095	MarC family integral membrane protein
LIW09_RS08350	COG1028	Short-chain dehydrogenase reductase Sdr
LIW09_RS08355	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
LIW09_RS08390	COG2969	positive regulation of protein catabolic process
LIW09_RS08395	COG0625	glutathione transferase activity
LIW09_RS08400	COG2857	Cytochrome c1
LIW09_RS08405	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
LIW09_RS08410	COG0723	plastoquinol--plastocyanin reductase activity
LIW09_RS08415	COG0741	lytic transglycosylase activity
LIW09_RS08420	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
LIW09_RS08430	COG1702	phosphate starvation-inducible protein PhoH
LIW09_RS08435	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
LIW09_RS08445	COG4535	Mg2 and Co2 transporter CorC
LIW09_RS08455	COG0598	Magnesium transport protein CorA
LIW09_RS08460	COG1716	ATPase activity
LIW09_RS08465	COG0823	Involved in the tonB-independent uptake of proteins
LIW09_RS08465	COG1506	peptidase
LIW09_RS08470	COG1297	OPT oligopeptide transporter protein
LIW09_RS08475	COG3104	oligopeptide transport
LIW09_RS08500	COG0306	phosphate transporter
LIW09_RS08510	COG1253	flavin adenine dinucleotide binding
LIW09_RS08545	COG1862	Preprotein translocase
LIW09_RS08550	COG0343	queuine tRNA-ribosyltransferase activity
LIW09_RS08555	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
LIW09_RS08560	COG1522	sequence-specific DNA binding
LIW09_RS08580	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LIW09_RS08585	COG0405	Gamma-glutamyltransferase
LIW09_RS08590	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
LIW09_RS08605	COG0742	ribosomal rna small subunit methyltransferase
LIW09_RS08620	COG1194	a g-specific adenine glycosylase
LIW09_RS08625	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
LIW09_RS08650	COG0149	triose-phosphate isomerase activity
LIW09_RS08670	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
LIW09_RS08685	COG0133	tryptophan synthase activity
LIW09_RS08690	COG0135	phosphoribosylanthranilate isomerase activity
LIW09_RS08695	COG0101	tRNA pseudouridine synthase activity
LIW09_RS08705	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
LIW09_RS08715	COG2890	protein-(glutamine-N5) methyltransferase activity
LIW09_RS08720	COG1999	signal sequence binding
LIW09_RS08760	COG0433	COG0433 Predicted ATPase
LIW09_RS08765	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
LIW09_RS08780	COG0625	glutathione transferase activity
LIW09_RS08810	COG4774	siderophore transport
LIW09_RS08820	COG0022	dehydrogenase e1 component
LIW09_RS08825	COG1960	acyl-CoA dehydrogenase activity
LIW09_RS08840	COG0084	hydrolase, TatD family'
LIW09_RS08845	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
LIW09_RS08850	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
LIW09_RS08910	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
LIW09_RS08955	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
LIW09_RS08970	COG0732	type I restriction modification DNA specificity domain
LIW09_RS08975	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
LIW09_RS08985	COG0840	transmembrane signaling receptor activity
LIW09_RS08995	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
LIW09_RS09010	COG0196	riboflavin kinase activity
LIW09_RS09030	COG0211	Belongs to the bacterial ribosomal protein bL27 family
LIW09_RS09050	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
LIW09_RS09065	COG0495	leucyl-tRNA aminoacylation
LIW09_RS09070	COG4095	Psort location CytoplasmicMembrane, score
LIW09_RS09095	COG3118	belongs to the thioredoxin family
LIW09_RS09110	COG0840	transmembrane signaling receptor activity
LIW09_RS09110	COG0840	transmembrane signaling receptor activity
LIW09_RS09125	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
LIW09_RS09140	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
LIW09_RS09155	COG2197	response regulator
LIW09_RS09160	COG4585	Histidine kinase
LIW09_RS09170	COG0850	regulation of cytokinetic process
LIW09_RS09175	COG2894	cell division
LIW09_RS09180	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
LIW09_RS09195	COG2814	Major facilitator Superfamily
LIW09_RS09200	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
LIW09_RS09200	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
LIW09_RS09210	COG1272	protein, Hemolysin III
LIW09_RS09230	COG0330	HflC and HflK could
LIW09_RS09235	COG0330	HflC and HflK could
LIW09_RS09240	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
LIW09_RS09250	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
LIW09_RS09255	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
LIW09_RS09260	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
LIW09_RS09270	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
LIW09_RS09275	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
LIW09_RS09280	COG1534	Rna-binding protein
LIW09_RS09290	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
LIW09_RS09295	COG1381	Involved in DNA repair and RecF pathway recombination
LIW09_RS09300	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
LIW09_RS09315	COG0681	Belongs to the peptidase S26 family
LIW09_RS09320	COG0481	GTPase activity
LIW09_RS09325	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LIW09_RS09355	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
LIW09_RS09360	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
LIW09_RS09370	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
LIW09_RS09385	COG1028	Short-chain dehydrogenase reductase Sdr
LIW09_RS09390	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
LIW09_RS09395	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
LIW09_RS09400	COG0333	Belongs to the bacterial ribosomal protein bL32 family
LIW09_RS09405	COG1399	metal-binding, possibly nucleic acid-binding protein
LIW09_RS09425	COG0714	Associated with various cellular activities
LIW09_RS09440	COG0537	adenosine 5'-monophosphoramidase activity
LIW09_RS09455	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
LIW09_RS09490	COG3642	lipopolysaccharide core region biosynthetic process
LIW09_RS09495	COG0859	PFAM glycosyl transferase family 9
LIW09_RS09510	COG0631	protein serine/threonine phosphatase activity
LIW09_RS09515	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
LIW09_RS09540	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
LIW09_RS09565	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
LIW09_RS09575	COG0544	peptidyl-prolyl cis-trans isomerase activity
LIW09_RS09605	COG0142	geranyltranstransferase activity
LIW09_RS09615	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
LIW09_RS09625	COG0527	aspartate kinase activity
LIW09_RS09635	COG0384	phenazine biosynthesis protein PhzF
LIW09_RS09640	COG0076	glutamate decarboxylase activity
LIW09_RS09650	COG0514	ATP-dependent DNA helicase (RecQ)
LIW09_RS09655	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
LIW09_RS09665	COG3409	Peptidoglycan-binding domain 1 protein
LIW09_RS09665	COG3267	Type II secretory pathway component ExeA
LIW09_RS09690	COG1704	LemA family
LIW09_RS09710	COG0513	Belongs to the DEAD box helicase family
LIW09_RS09740	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LIW09_RS09745	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LIW09_RS09755	COG2096	Adenosyltransferase
LIW09_RS09760	COG0123	including yeast histone deacetylase and acetoin utilization protein
LIW09_RS09765	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
LIW09_RS09775	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
LIW09_RS09785	COG2967	ApaG domain
LIW09_RS09790	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
LIW09_RS09800	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
LIW09_RS09805	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
LIW09_RS09810	COG0861	Integral membrane protein TerC family
LIW09_RS09815	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
LIW09_RS09820	COG0577	efflux transmembrane transporter activity
LIW09_RS09820	COG1136	(ABC) transporter
LIW09_RS09825	COG0577	efflux transmembrane transporter activity
LIW09_RS09825	COG1136	(ABC) transporter
LIW09_RS09830	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LIW09_RS09835	COG0642	Histidine kinase
LIW09_RS09845	COG3956	TIGRFAM MazG family protein
LIW09_RS09855	COG0494	nUDIX hydrolase
LIW09_RS09865	COG1385	rRNA (uridine-N3-)-methyltransferase activity
LIW09_RS09880	COG0643	Histidine kinase
LIW09_RS09880	COG0784	Response regulator, receiver
LIW09_RS09880	COG2198	Histidine kinase
LIW09_RS09885	COG0840	transmembrane signaling receptor activity
LIW09_RS09905	COG0189	ligase activity
LIW09_RS09925	COG1199	ATP-dependent helicase activity
LIW09_RS09930	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
LIW09_RS09935	COG1216	Glycosyl transferase, family 2
LIW09_RS09935	COG0438	transferase activity, transferring glycosyl groups
LIW09_RS09945	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
LIW09_RS09950	COG1643	Atp-dependent helicase
LIW09_RS09955	COG0783	Belongs to the Dps family
LIW09_RS09980	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
LIW09_RS09985	COG0602	queuosine metabolic process
LIW09_RS09995	COG2885	chlorophyll binding
LIW09_RS10020	COG0824	Thioesterase
LIW09_RS10030	COG5001	Diguanylate cyclase
LIW09_RS10040	COG0632	four-way junction helicase activity
LIW09_RS10045	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
LIW09_RS10050	COG0217	transcriptional regulatory protein
LIW09_RS10075	COG0488	(ABC) transporter
LIW09_RS10085	COG4651	solute:proton antiporter activity
LIW09_RS10085	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
LIW09_RS10090	COG0542	response to heat
LIW09_RS10110	COG0564	pseudouridine synthase activity
LIW09_RS10115	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
LIW09_RS10125	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
LIW09_RS10135	COG0355	proton-transporting ATP synthase activity, rotational mechanism
LIW09_RS10140	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
LIW09_RS10150	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
LIW09_RS10155	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
LIW09_RS10160	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
LIW09_RS10170	COG0356	it plays a direct role in the translocation of protons across the membrane
LIW09_RS10185	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
LIW09_RS10190	COG0508	dehydrogenase complex catalyzes the overall conversion of
LIW09_RS10195	COG0697	spore germination
LIW09_RS10200	COG1666	GTP binding
LIW09_RS10205	COG1187	pseudouridine synthase activity
LIW09_RS10210	COG2813	Specifically methylates the guanine in position
LIW09_RS10230	COG1793	dna ligase
LIW09_RS10235	COG2972	Histidine kinase
LIW09_RS10255	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
LIW09_RS10260	COG0281	malic enzyme
LIW09_RS10260	COG0280	phosphate acetyltransferase
LIW09_RS10275	COG1162	GTPase activity
LIW09_RS10280	COG0436	Aminotransferase
LIW09_RS10290	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
LIW09_RS10305	COG1307	EDD domain protein, DegV family
LIW09_RS10320	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
LIW09_RS10325	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
LIW09_RS10365	COG1773	rubredoxin
LIW09_RS10370	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
LIW09_RS10375	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
LIW09_RS10385	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
LIW09_RS10390	COG0346	lactoylglutathione lyase activity
LIW09_RS10400	COG0671	phosphoesterase, PA-phosphatase related
LIW09_RS10405	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
LIW09_RS10425	COG1872	DUF167
LIW09_RS10445	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
LIW09_RS10455	COG0045	succinate-CoA ligase (ADP-forming) activity
LIW09_RS10475	COG1215	transferase activity, transferring glycosyl groups
LIW09_RS10485	COG0126	phosphoglycerate kinase activity
LIW09_RS10490	COG4251	negative regulation of phosphorylation
LIW09_RS10490	COG3706	GGDEF domain
LIW09_RS10490	COG2203	Gaf domain
LIW09_RS10490	COG5001	Diguanylate cyclase
LIW09_RS10495	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
LIW09_RS10500	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
LIW09_RS10540	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
LIW09_RS10585	COG4245	von Willebrand factor, type A
LIW09_RS10600	COG4245	von Willebrand factor, type A
LIW09_RS10655	COG0714	Associated with various cellular activities
LIW09_RS10695	COG0372	Belongs to the citrate synthase family
LIW09_RS10700	COG0254	rRNA binding
LIW09_RS10750	COG0446	pyridine nucleotide-disulphide oxidoreductase
LIW09_RS10755	COG0640	Transcriptional regulator
LIW09_RS10760	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
LIW09_RS10780	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
LIW09_RS10785	COG1758	RNA polymerase activity
LIW09_RS10790	COG0194	GDP metabolic process
LIW09_RS10795	COG1561	YicC-like family, N-terminal region
LIW09_RS10800	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
LIW09_RS10810	COG0635	Involved in the biosynthesis of porphyrin-containing compound
LIW09_RS10825	COG0006	proline dipeptidase activity
LIW09_RS10830	COG0006	proline dipeptidase activity
LIW09_RS10860	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
LIW09_RS10875	COG0129	dihydroxy-acid dehydratase activity
LIW09_RS10880	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
LIW09_RS10900	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
LIW09_RS10905	COG0473	3-isopropylmalate dehydrogenase activity
LIW09_RS10910	COG0066	3-isopropylmalate dehydratase activity
LIW09_RS10915	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
LIW09_RS10925	COG3706	GGDEF domain
LIW09_RS10935	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LIW09_RS10945	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
LIW09_RS10950	COG1538	Outer membrane efflux protein
LIW09_RS10955	COG1519	Transferase
LIW09_RS10980	COG1741	Belongs to the pirin family
LIW09_RS10985	COG2353	YceI-like domain
LIW09_RS10990	COG0778	Nitroreductase
LIW09_RS11000	COG1131	(ABC) transporter
LIW09_RS11010	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
LIW09_RS11015	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
LIW09_RS11055	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
LIW09_RS11070	COG1324	tolerance protein
LIW09_RS11080	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
LIW09_RS11085	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
LIW09_RS11090	COG0511	ligase activity, forming carbon-carbon bonds
LIW09_RS11095	COG0439	Biotin carboxylase
LIW09_RS11105	COG2264	protein methyltransferase activity
LIW09_RS11115	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
LIW09_RS11120	COG0138	bifunctional purine biosynthesis protein purh
LIW09_RS11125	COG0151	Belongs to the GarS family
LIW09_RS11140	COG3384	dioxygenase
LIW09_RS11145	COG1902	pentaerythritol trinitrate reductase activity
LIW09_RS11155	COG0564	pseudouridine synthase activity
LIW09_RS11170	COG2086	electron transfer activity
LIW09_RS11180	COG0438	transferase activity, transferring glycosyl groups
LIW09_RS11180	COG1216	Glycosyl transferase, family 2
LIW09_RS11215	COG0625	glutathione transferase activity
LIW09_RS11235	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
LIW09_RS11240	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
LIW09_RS11260	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
LIW09_RS11265	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
LIW09_RS11280	COG0134	indole-3-glycerol-phosphate synthase activity
LIW09_RS11300	COG0745	RESPONSE REGULATOR receiver
LIW09_RS11320	COG2963	transposase activity
LIW09_RS11345	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
LIW09_RS11350	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
LIW09_RS11370	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
LIW09_RS11385	COG3104	oligopeptide transport
LIW09_RS11390	COG3483	tryptophan 2,3-dioxygenase activity
LIW09_RS11410	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
LIW09_RS11415	COG1956	GAF domain-containing protein
LIW09_RS11425	COG4206	TonB-dependent receptor
LIW09_RS11440	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
LIW09_RS11450	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
LIW09_RS11455	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
LIW09_RS11460	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LIW09_RS11465	COG1136	(ABC) transporter
LIW09_RS11465	COG0577	efflux transmembrane transporter activity
LIW09_RS11470	COG0577	efflux transmembrane transporter activity
LIW09_RS11470	COG1136	(ABC) transporter
LIW09_RS11475	COG0577	efflux transmembrane transporter activity
LIW09_RS11485	COG4191	Histidine kinase
LIW09_RS11495	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
LIW09_RS11510	COG0218	Necessary for normal cell division and for the maintenance of normal septation
LIW09_RS11515	COG2863	cytochrome
LIW09_RS11525	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
LIW09_RS11535	COG0730	response to heat
LIW09_RS11540	COG0741	lytic transglycosylase activity
LIW09_RS11580	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
LIW09_RS11585	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
LIW09_RS11605	COG0358	DNA primase activity
LIW09_RS11610	COG2169	Transcriptional regulator
LIW09_RS11610	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
LIW09_RS11615	COG3145	DNA-N1-methyladenine dioxygenase activity
LIW09_RS11620	COG0109	protoheme IX farnesyltransferase activity
LIW09_RS11645	COG1845	cytochrome c oxidase, subunit III
LIW09_RS11650	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
LIW09_RS11660	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
LIW09_RS11665	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
LIW09_RS11675	COG2067	long-chain fatty acid transport protein
LIW09_RS11685	COG0793	Belongs to the peptidase S41A family
LIW09_RS11690	COG4942	peptidase
LIW09_RS11695	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
LIW09_RS11705	COG2234	aminopeptidase activity
LIW09_RS11740	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
LIW09_RS11745	COG0739	heme binding
LIW09_RS11750	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
LIW09_RS11755	COG2211	Major facilitator Superfamily
LIW09_RS11775	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
LIW09_RS11790	COG2003	Belongs to the UPF0758 family
LIW09_RS11795	COG0018	arginyl-trna synthetase
LIW09_RS11810	COG4221	oxidoreductase activity
LIW09_RS11825	COG1166	arginine decarboxylase activity
LIW09_RS11850	COG2960	long-chain fatty acid transporting porin activity
LIW09_RS11855	COG0606	chelatase, subunit chli
LIW09_RS11875	COG3706	GGDEF domain
LIW09_RS11885	COG2224	Isocitrate lyase
LIW09_RS11890	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
LIW09_RS11895	COG0583	DNA-binding transcription factor activity
LIW09_RS11905	COG3550	peptidyl-serine autophosphorylation
LIW09_RS11925	COG1040	competence protein
LIW09_RS11955	COG0697	spore germination
LIW09_RS11960	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
LIW09_RS11975	COG0357	Ribosomal RNA small subunit methyltransferase G
LIW09_RS11980	COG1192	Involved in chromosome partitioning
LIW09_RS11985	COG1475	DNA binding
LIW09_RS11990	COG0463	Glycosyl transferase, family 2
LIW09_RS12005	COG0227	Belongs to the bacterial ribosomal protein bL28 family
LIW09_RS12010	COG0267	Belongs to the bacterial ribosomal protein bL33 family
LIW09_RS12020	COG1968	undecaprenyl-diphosphatase activity
LIW09_RS12025	COG0174	glutamine synthetase
LIW09_RS12030	COG0004	ammonium transporteR
LIW09_RS12045	COG3291	Pkd domain containing protein
LIW09_RS12060	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
LIW09_RS12070	COG1506	peptidase
LIW09_RS12070	COG0823	Involved in the tonB-independent uptake of proteins
LIW09_RS12075	COG0006	proline dipeptidase activity
LIW09_RS12090	COG3938	Belongs to the proline racemase family
LIW09_RS12095	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
LIW09_RS12105	COG3852	Histidine kinase
LIW09_RS12115	COG2032	superoxide dismutase activity
LIW09_RS12125	COG0183	Belongs to the thiolase family
LIW09_RS12130	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
LIW09_RS12140	COG3100	YcgL domain-containing protein
LIW09_RS12165	COG0493	'glutamate synthase
LIW09_RS12170	COG0070	glutamate synthase
LIW09_RS12170	COG0069	glutamate synthase activity
LIW09_RS12170	COG0067	glutamate synthase
LIW09_RS12175	COG0009	L-threonylcarbamoyladenylate synthase
LIW09_RS12195	COG2922	Belongs to the Smg family
LIW09_RS12200	COG0758	DNA mediated transformation
LIW09_RS12210	COG0242	peptide deformylase activity
LIW09_RS12220	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
LIW09_RS12220	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
LIW09_RS12230	COG1215	transferase activity, transferring glycosyl groups
LIW09_RS12235	COG0463	Glycosyl transferase, family 2
LIW09_RS12255	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
LIW09_RS12320	COG0181	hydroxymethylbilane synthase activity
LIW09_RS12345	COG1505	serine-type exopeptidase activity
LIW09_RS12365	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
LIW09_RS12385	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
LIW09_RS12390	COG1881	PFAM PEBP family protein
LIW09_RS12405	COG2050	protein possibly involved in aromatic compounds catabolism
LIW09_RS12415	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
LIW09_RS12425	COG5002	protein histidine kinase activity
LIW09_RS12425	COG0784	Response regulator, receiver
LIW09_RS12425	COG2198	Histidine kinase
LIW09_RS12435	COG3525	Glycosyl hydrolase, family 20, catalytic domain
LIW09_RS12450	COG0738	Major facilitator superfamily
LIW09_RS12455	COG1609	Transcriptional regulator
LIW09_RS12460	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
LIW09_RS12465	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
LIW09_RS12510	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
LIW09_RS12515	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
LIW09_RS12515	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
LIW09_RS12540	COG1187	pseudouridine synthase activity
LIW09_RS12545	COG2205	protein histidine kinase activity
LIW09_RS12555	COG1643	Atp-dependent helicase
LIW09_RS12560	COG0084	hydrolase, TatD family'
LIW09_RS12570	COG0842	Transport permease protein
LIW09_RS12575	COG1131	(ABC) transporter
LIW09_RS12605	COG4555	ABC transporter
LIW09_RS12625	COG0706	membrane insertase activity
LIW09_RS12630	COG0594	ribonuclease P activity
LIW09_RS12640	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
LIW09_RS12650	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP