locus-tag	class	description
D3U04_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
D3U04_RS00010	COG0592	DNA-directed DNA polymerase activity
D3U04_RS00015	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
D3U04_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
D3U04_RS00025	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
D3U04_RS00030	COG0187	DNA topoisomerase II activity
D3U04_RS00035	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
D3U04_RS00240	COG4977	sequence-specific DNA binding
D3U04_RS00250	COG0667	Aldo Keto reductase
D3U04_RS00325	COG2188	Transcriptional regulator
D3U04_RS00375	COG1434	Gram-negative-bacterium-type cell wall biogenesis
D3U04_RS00395	COG3119	arylsulfatase activity
D3U04_RS00400	COG4977	sequence-specific DNA binding
D3U04_RS00410	COG0513	Belongs to the DEAD box helicase family
D3U04_RS00430	COG0705	Rhomboid family
D3U04_RS00440	COG3764	Sortase (surface protein transpeptidase)
D3U04_RS00455	COG0515	serine threonine protein kinase
D3U04_RS00460	COG0515	serine threonine protein kinase
D3U04_RS00465	COG0768	penicillin binding
D3U04_RS00480	COG1716	ATPase activity
D3U04_RS00505	COG1131	(ABC) transporter
D3U04_RS00515	COG1252	NADH dehydrogenase
D3U04_RS00525	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
D3U04_RS00540	COG0475	glutathione-regulated potassium exporter activity
D3U04_RS00545	COG1028	Short-chain dehydrogenase reductase Sdr
D3U04_RS00550	COG1309	transcriptional regulator
D3U04_RS00555	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
D3U04_RS00560	COG0702	epimerase
D3U04_RS00670	COG1280	lysine exporter protein (LysE YggA)
D3U04_RS00695	COG0604	alcohol dehydrogenase
D3U04_RS00710	COG0561	phosphatase activity
D3U04_RS00715	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
D3U04_RS00720	COG2226	methyltransferase
D3U04_RS00735	COG0077	Prephenate dehydratase
D3U04_RS00745	COG5650	phosphatidylinositol metabolic process
D3U04_RS00755	COG1215	transferase activity, transferring glycosyl groups
D3U04_RS00760	COG1366	Belongs to the anti-sigma-factor antagonist family
D3U04_RS00770	COG5002	protein histidine kinase activity
D3U04_RS00775	COG0745	RESPONSE REGULATOR receiver
D3U04_RS00795	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
D3U04_RS00850	COG0596	Alpha beta hydrolase
D3U04_RS00870	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
D3U04_RS00880	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D3U04_RS00920	COG2235	arginine
D3U04_RS00960	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
D3U04_RS00970	COG2608	mercury ion transmembrane transporter activity
D3U04_RS01015	COG0702	epimerase
D3U04_RS01035	COG0655	NAD(P)H dehydrogenase (quinone) activity
D3U04_RS01055	COG1595	DNA-templated transcription, initiation
D3U04_RS01060	COG0318	PFAM AMP-dependent synthetase and ligase
D3U04_RS01080	COG1028	Short-chain dehydrogenase reductase Sdr
D3U04_RS01125	COG1595	DNA-templated transcription, initiation
D3U04_RS01170	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
D3U04_RS01180	COG3119	arylsulfatase activity
D3U04_RS01190	COG1595	DNA-templated transcription, initiation
D3U04_RS01200	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
D3U04_RS01205	COG1414	Transcriptional regulator
D3U04_RS01210	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
D3U04_RS01215	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
D3U04_RS01220	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
D3U04_RS01260	COG0789	Transcriptional regulator
D3U04_RS01285	COG0584	glycerophosphoryl diester phosphodiesterase
D3U04_RS01310	COG1968	undecaprenyl-diphosphatase activity
D3U04_RS01360	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D3U04_RS01365	COG0318	PFAM AMP-dependent synthetase and ligase
D3U04_RS01365	COG0204	Acyl-transferase
D3U04_RS01380	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
D3U04_RS01385	COG0697	spore germination
D3U04_RS01390	COG0596	Alpha beta hydrolase
D3U04_RS01400	COG0702	epimerase
D3U04_RS01415	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
D3U04_RS01420	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
D3U04_RS01430	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
D3U04_RS01455	COG0151	Belongs to the GarS family
D3U04_RS01470	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
D3U04_RS01505	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
D3U04_RS01520	COG1432	Conserved Protein
D3U04_RS01530	COG1028	Short-chain dehydrogenase reductase Sdr
D3U04_RS01540	COG1309	transcriptional regulator
D3U04_RS01555	COG0542	response to heat
D3U04_RS01560	COG0789	Transcriptional regulator
D3U04_RS01565	COG0484	heat shock protein binding
D3U04_RS01570	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
D3U04_RS01575	COG0443	Heat shock 70 kDa protein
D3U04_RS01580	COG1595	DNA-templated transcription, initiation
D3U04_RS01600	COG1404	Belongs to the peptidase S8 family
D3U04_RS01640	COG2181	nitrate reductase activity
D3U04_RS01640	COG0247	lactate metabolic process
D3U04_RS01645	COG0456	acetyltransferase
D3U04_RS01650	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
D3U04_RS01655	COG1917	Cupin 2, conserved barrel domain protein
D3U04_RS01660	COG5285	phytanoyl-CoA dioxygenase
D3U04_RS01665	COG0717	Belongs to the dCTP deaminase family
D3U04_RS01695	COG1733	regulation of RNA biosynthetic process
D3U04_RS01715	COG0492	ferredoxin-NADP+ reductase activity
D3U04_RS01720	COG0778	Nitroreductase
D3U04_RS01725	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
D3U04_RS01740	COG1132	(ABC) transporter
D3U04_RS01760	COG2885	chlorophyll binding
D3U04_RS01790	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
D3U04_RS01795	COG0406	alpha-ribazole phosphatase activity
D3U04_RS01795	COG0494	nUDIX hydrolase
D3U04_RS01800	COG3025	triphosphatase activity
D3U04_RS01800	COG5607	PFAM CHAD domain containing protein
D3U04_RS01865	COG4221	oxidoreductase activity
D3U04_RS01935	COG1960	acyl-CoA dehydrogenase activity
D3U04_RS01970	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D3U04_RS01980	COG2124	cytochrome p450
D3U04_RS02015	COG0167	dihydroorotate dehydrogenase activity
D3U04_RS02025	COG0860	N-Acetylmuramoyl-L-alanine amidase
D3U04_RS02065	COG2949	membrane
D3U04_RS02070	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
D3U04_RS02100	COG1733	regulation of RNA biosynthetic process
D3U04_RS02115	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
D3U04_RS02120	COG0047	phosphoribosylformylglycinamidine synthase activity
D3U04_RS02130	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
D3U04_RS02170	COG1595	DNA-templated transcription, initiation
D3U04_RS02190	COG1012	belongs to the aldehyde dehydrogenase family
D3U04_RS02200	COG0022	dehydrogenase e1 component
D3U04_RS02205	COG0508	dehydrogenase complex catalyzes the overall conversion of
D3U04_RS02210	COG1966	Carbon starvation protein
D3U04_RS02225	COG1819	glycosyl
D3U04_RS02250	COG1120	ATPase activity
D3U04_RS02255	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D3U04_RS02280	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D3U04_RS02285	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D3U04_RS02290	COG1120	ATPase activity
D3U04_RS02310	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
D3U04_RS02315	COG1021	2,3-dihydroxybenzoate-AMP ligase
D3U04_RS02345	COG1169	isochorismate synthase
D3U04_RS02375	COG0789	Transcriptional regulator
D3U04_RS02380	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
D3U04_RS02410	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D3U04_RS02475	COG3509	depolymerase
D3U04_RS02490	COG1902	pentaerythritol trinitrate reductase activity
D3U04_RS02510	COG1028	Short-chain dehydrogenase reductase Sdr
D3U04_RS02575	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
D3U04_RS02585	COG0318	PFAM AMP-dependent synthetase and ligase
D3U04_RS02590	COG2814	Major facilitator Superfamily
D3U04_RS02605	COG0640	Transcriptional regulator
D3U04_RS02655	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
D3U04_RS02710	COG1674	ftsk spoiiie
D3U04_RS02740	COG2197	response regulator
D3U04_RS02750	COG0267	Belongs to the bacterial ribosomal protein bL33 family
D3U04_RS02755	COG0254	rRNA binding
D3U04_RS02785	COG0477	Major facilitator Superfamily
D3U04_RS02790	COG1982	Orn Lys Arg decarboxylase major
D3U04_RS02810	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
D3U04_RS02815	COG0142	geranyltranstransferase activity
D3U04_RS02825	COG1595	DNA-templated transcription, initiation
D3U04_RS02835	COG0406	alpha-ribazole phosphatase activity
D3U04_RS02850	COG3226	Transcriptional regulator
D3U04_RS02855	COG0110	maltose O-acetyltransferase activity
D3U04_RS02865	COG1136	(ABC) transporter
D3U04_RS02915	COG2409	Drug exporters of the RND superfamily
D3U04_RS02920	COG0477	Major facilitator Superfamily
D3U04_RS02940	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D3U04_RS02945	COG1116	anion transmembrane transporter activity
D3U04_RS02955	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D3U04_RS02965	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
D3U04_RS02975	COG0431	NADPH-dependent FMN reductase
D3U04_RS03045	COG1132	(ABC) transporter
D3U04_RS03060	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D3U04_RS03065	COG3189	MarR family transcriptional regulator
D3U04_RS03080	COG0675	Transposase, IS605 OrfB family
D3U04_RS03090	COG1960	acyl-CoA dehydrogenase activity
D3U04_RS03120	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
D3U04_RS03160	COG1595	DNA-templated transcription, initiation
D3U04_RS03165	COG0446	pyridine nucleotide-disulphide oxidoreductase
D3U04_RS03185	COG1309	transcriptional regulator
D3U04_RS03235	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
D3U04_RS03240	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
D3U04_RS03245	COG1278	Cold shock
D3U04_RS03255	COG1960	acyl-CoA dehydrogenase activity
D3U04_RS03290	COG3293	Transposase
D3U04_RS03300	COG2226	methyltransferase
D3U04_RS03310	COG2814	Major facilitator Superfamily
D3U04_RS03315	COG0640	Transcriptional regulator
D3U04_RS03340	COG1846	Transcriptional regulator
D3U04_RS03355	COG3903	Transcriptional regulator
D3U04_RS03355	COG3629	intracellular signal transduction
D3U04_RS03385	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
D3U04_RS03435	COG3903	Transcriptional regulator
D3U04_RS03435	COG3629	intracellular signal transduction
D3U04_RS03475	COG3290	protein histidine kinase activity
D3U04_RS03485	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
D3U04_RS03515	COG0617	tRNA 3'-terminal CCA addition
D3U04_RS03515	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
D3U04_RS03515	COG3620	sequence-specific DNA binding
D3U04_RS03585	COG4585	Histidine kinase
D3U04_RS03650	COG0791	NLP P60 protein
D3U04_RS03650	COG1388	LysM domain
D3U04_RS03695	COG1028	Short-chain dehydrogenase reductase Sdr
D3U04_RS03705	COG1024	Enoyl-CoA hydratase
D3U04_RS03710	COG0745	RESPONSE REGULATOR receiver
D3U04_RS03715	COG2205	protein histidine kinase activity
D3U04_RS03720	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
D3U04_RS03730	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
D3U04_RS03735	COG0242	peptide deformylase activity
D3U04_RS03750	COG0464	growth
D3U04_RS03760	COG1392	Phosphate transport regulator
D3U04_RS03770	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
D3U04_RS03790	COG0456	acetyltransferase
D3U04_RS03795	COG0745	RESPONSE REGULATOR receiver
D3U04_RS03830	COG2897	thiosulfate sulfurtransferase activity
D3U04_RS03840	COG1404	Belongs to the peptidase S8 family
D3U04_RS03850	COG0477	Major facilitator Superfamily
D3U04_RS03860	COG5285	phytanoyl-CoA dioxygenase
D3U04_RS03865	COG0318	PFAM AMP-dependent synthetase and ligase
D3U04_RS03895	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
D3U04_RS03900	COG0243	molybdopterin cofactor binding
D3U04_RS03905	COG2223	nitrite transmembrane transporter activity
D3U04_RS03910	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
D3U04_RS03915	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
D3U04_RS03920	COG0142	geranyltranstransferase activity
D3U04_RS03925	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
D3U04_RS03940	COG1028	Short-chain dehydrogenase reductase Sdr
D3U04_RS03985	COG1674	ftsk spoiiie
D3U04_RS04000	COG4842	Belongs to the WXG100 family
D3U04_RS04005	COG4842	Belongs to the WXG100 family
D3U04_RS04025	COG4842	Belongs to the WXG100 family
D3U04_RS04030	COG4842	Belongs to the WXG100 family
D3U04_RS04075	COG1316	TRANSCRIPTIONal
D3U04_RS04085	COG1216	Glycosyl transferase, family 2
D3U04_RS04100	COG1216	Glycosyl transferase, family 2
D3U04_RS04125	COG3119	arylsulfatase activity
D3U04_RS04190	COG3442	glutamine amidotransferase
D3U04_RS04215	COG4044	May play a role in the intracellular transport of hydrophobic ligands
D3U04_RS04220	COG0586	Pfam SNARE associated Golgi protein
D3U04_RS04225	COG0735	belongs to the Fur family
D3U04_RS04230	COG0354	folic acid binding
D3U04_RS04240	COG1490	D-aminoacyl-tRNA deacylase activity
D3U04_RS04245	COG3246	L-lysine catabolic process to acetate
D3U04_RS04265	COG2321	neutral zinc metallopeptidase
D3U04_RS04290	COG1309	transcriptional regulator
D3U04_RS04295	COG2409	Drug exporters of the RND superfamily
D3U04_RS04305	COG0640	Transcriptional regulator
D3U04_RS04315	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
D3U04_RS04325	COG1271	oxidase subunit
D3U04_RS04345	COG3384	dioxygenase
D3U04_RS04350	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
D3U04_RS04355	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
D3U04_RS04375	COG0438	transferase activity, transferring glycosyl groups
D3U04_RS04385	COG0588	phosphoglycerate mutase activity
D3U04_RS04395	COG5002	protein histidine kinase activity
D3U04_RS04400	COG0745	RESPONSE REGULATOR receiver
D3U04_RS04420	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
D3U04_RS04425	COG0179	Fumarylacetoacetate (FAA) hydrolase
D3U04_RS04450	COG0215	cysteine-tRNA ligase activity
D3U04_RS04485	COG1802	Transcriptional regulator
D3U04_RS04490	COG0277	FAD linked oxidase domain protein
D3U04_RS04490	COG0247	lactate metabolic process
D3U04_RS04495	COG1454	alcohol dehydrogenase
D3U04_RS04505	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
D3U04_RS04515	COG0514	ATP-dependent DNA helicase (RecQ)
D3U04_RS04525	COG2205	protein histidine kinase activity
D3U04_RS04530	COG0745	RESPONSE REGULATOR receiver
D3U04_RS04540	COG1672	PFAM Archaeal ATPase
D3U04_RS04540	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
D3U04_RS04560	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
D3U04_RS04570	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
D3U04_RS04585	COG0443	Heat shock 70 kDa protein
D3U04_RS04595	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
D3U04_RS04610	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
D3U04_RS04685	COG1940	carbohydrate kinase activity
D3U04_RS04700	COG0395	ABC-type sugar transport system, permease component
D3U04_RS04705	COG2723	6-phospho-beta-galactosidase activity
D3U04_RS04735	COG0596	Alpha beta hydrolase
D3U04_RS04750	COG0583	DNA-binding transcription factor activity
D3U04_RS04775	COG0583	DNA-binding transcription factor activity
D3U04_RS04850	COG0515	serine threonine protein kinase
D3U04_RS04855	COG1595	DNA-templated transcription, initiation
D3U04_RS04860	COG0457	Tetratricopeptide repeat
D3U04_RS04915	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D3U04_RS04945	COG0459	protein refolding
D3U04_RS04975	COG1061	Type III restriction enzyme res subunit
D3U04_RS04995	COG0318	PFAM AMP-dependent synthetase and ligase
D3U04_RS05010	COG1309	transcriptional regulator
D3U04_RS05025	COG1278	Cold shock
D3U04_RS05030	COG2814	Major facilitator Superfamily
D3U04_RS05105	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
D3U04_RS05130	COG0259	pyridoxamine-phosphate oxidase activity
D3U04_RS05135	COG0477	Major facilitator Superfamily
D3U04_RS05140	COG1573	uracil-dna glycosylase
D3U04_RS05155	COG2226	methyltransferase
D3U04_RS05175	COG0477	Major facilitator Superfamily
D3U04_RS05180	COG0183	Belongs to the thiolase family
D3U04_RS05190	COG0789	Transcriptional regulator
D3U04_RS05205	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
D3U04_RS05210	COG1672	PFAM Archaeal ATPase
D3U04_RS05210	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
D3U04_RS05230	COG1012	belongs to the aldehyde dehydrogenase family
D3U04_RS05235	COG1012	belongs to the aldehyde dehydrogenase family
D3U04_RS05250	COG0416	fatty acid biosynthetic process
D3U04_RS05270	COG1881	PFAM PEBP family protein
D3U04_RS05295	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D3U04_RS05305	COG0442	prolyl-tRNA aminoacylation
D3U04_RS05330	COG1595	DNA-templated transcription, initiation
D3U04_RS05340	COG0515	serine threonine protein kinase
D3U04_RS05340	COG2815	serine threonine protein kinase
D3U04_RS05365	COG0612	Peptidase, M16
D3U04_RS05370	COG1366	Belongs to the anti-sigma-factor antagonist family
D3U04_RS05440	COG0640	Transcriptional regulator
D3U04_RS05465	COG2197	response regulator
D3U04_RS05470	COG0318	PFAM AMP-dependent synthetase and ligase
D3U04_RS05475	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
D3U04_RS05480	COG2252	PERMEase
D3U04_RS05545	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
D3U04_RS05555	COG2409	Drug exporters of the RND superfamily
D3U04_RS05565	COG3263	regulation of cellular component size
D3U04_RS05570	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
D3U04_RS05575	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
D3U04_RS05580	COG1210	Utp--glucose-1-phosphate uridylyltransferase
D3U04_RS05590	COG0315	cyclic pyranopterin monophosphate synthase activity
D3U04_RS05595	COG0521	Mo-molybdopterin cofactor biosynthetic process
D3U04_RS05600	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
D3U04_RS05625	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
D3U04_RS05635	COG1595	DNA-templated transcription, initiation
D3U04_RS05640	COG0667	Aldo Keto reductase
D3U04_RS05665	COG1846	Transcriptional regulator
D3U04_RS05685	COG3552	Protein containing von Willebrand factor type A (VWA) domain
D3U04_RS05690	COG2425	protein containing a von Willebrand factor type A (vWA) domain
D3U04_RS05695	COG0714	Associated with various cellular activities
D3U04_RS05700	COG3831	ATPase activity
D3U04_RS05705	COG3831	ATPase activity
D3U04_RS05720	COG1609	Transcriptional regulator
D3U04_RS05765	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
D3U04_RS05770	COG0084	hydrolase, TatD family'
D3U04_RS05785	COG0741	lytic transglycosylase activity
D3U04_RS05790	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
D3U04_RS05800	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
D3U04_RS05810	COG0488	(ABC) transporter
D3U04_RS05815	COG1846	Transcriptional regulator
D3U04_RS05825	COG4106	trans-aconitate 2-methyltransferase activity
D3U04_RS05850	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
D3U04_RS05855	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
D3U04_RS05860	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
D3U04_RS05865	COG0193	aminoacyl-tRNA hydrolase activity
D3U04_RS05875	COG1218	3'(2'),5'-bisphosphate nucleotidase
D3U04_RS05905	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
D3U04_RS05955	COG0730	response to heat
D3U04_RS05960	COG0529	Catalyzes the synthesis of activated sulfate
D3U04_RS05985	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
D3U04_RS05990	COG4191	Histidine kinase
D3U04_RS05995	COG3118	belongs to the thioredoxin family
D3U04_RS05995	COG0492	ferredoxin-NADP+ reductase activity
D3U04_RS06005	COG1703	isobutyryl-CoA mutase activity
D3U04_RS06005	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
D3U04_RS06005	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
D3U04_RS06015	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
D3U04_RS06040	COG0148	phosphopyruvate hydratase activity
D3U04_RS06070	COG1252	NADH dehydrogenase
D3U04_RS06075	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
D3U04_RS06095	COG0183	Belongs to the thiolase family
D3U04_RS06105	COG2755	lipolytic protein G-D-S-L family
D3U04_RS06125	COG2409	Drug exporters of the RND superfamily
D3U04_RS06150	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
D3U04_RS06165	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
D3U04_RS06185	COG1714	RDD family
D3U04_RS06190	COG3185	4-Hydroxyphenylpyruvate dioxygenase
D3U04_RS06200	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
D3U04_RS06210	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
D3U04_RS06230	COG1234	tRNA 3'-trailer cleavage
D3U04_RS06235	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
D3U04_RS06240	COG1331	Highly conserved protein containing a thioredoxin domain
D3U04_RS06255	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
D3U04_RS06260	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
D3U04_RS06275	COG0114	fumarate hydratase activity
D3U04_RS06290	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
D3U04_RS06290	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
D3U04_RS06295	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D3U04_RS06330	COG1722	exodeoxyribonuclease VII activity
D3U04_RS06335	COG1570	exodeoxyribonuclease VII activity
D3U04_RS06345	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
D3U04_RS06355	COG1322	Protein conserved in bacteria
D3U04_RS06360	COG0657	acetylesterase activity
D3U04_RS06365	COG0012	GTP binding
D3U04_RS06420	COG0494	nUDIX hydrolase
D3U04_RS06430	COG1217	gtp-binding protein TYPA
D3U04_RS06450	COG0542	response to heat
D3U04_RS06500	COG1053	succinate dehydrogenase
D3U04_RS06510	COG0784	Response regulator, receiver
D3U04_RS06515	COG4251	negative regulation of phosphorylation
D3U04_RS06525	COG1132	(ABC) transporter
D3U04_RS06545	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
D3U04_RS06555	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
D3U04_RS06560	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
D3U04_RS06565	COG1522	sequence-specific DNA binding
D3U04_RS06570	COG0515	serine threonine protein kinase
D3U04_RS06570	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
D3U04_RS06575	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
D3U04_RS06600	COG0215	cysteine-tRNA ligase activity
D3U04_RS06615	COG1024	Enoyl-CoA hydratase
D3U04_RS06620	COG0726	polysaccharide deacetylase
D3U04_RS06670	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
D3U04_RS06680	COG1960	acyl-CoA dehydrogenase activity
D3U04_RS06690	COG2171	N-acyltransferase activity
D3U04_RS06695	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
D3U04_RS06700	COG2890	protein-(glutamine-N5) methyltransferase activity
D3U04_RS06705	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D3U04_RS06710	COG1611	Belongs to the LOG family
D3U04_RS06715	COG1611	Belongs to the LOG family
D3U04_RS06740	COG2818	Glycosylase
D3U04_RS06750	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
D3U04_RS06755	COG4122	O-methyltransferase activity
D3U04_RS06760	COG1595	DNA-templated transcription, initiation
D3U04_RS06775	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
D3U04_RS06780	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
D3U04_RS06800	COG2239	Acts as a magnesium transporter
D3U04_RS06825	COG0583	DNA-binding transcription factor activity
D3U04_RS06840	COG1266	CAAX protease self-immunity
D3U04_RS06855	COG0494	nUDIX hydrolase
D3U04_RS06880	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
D3U04_RS06890	COG0513	Belongs to the DEAD box helicase family
D3U04_RS06935	COG3285	dna ligase
D3U04_RS06935	COG1793	dna ligase
D3U04_RS06945	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
D3U04_RS06990	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
D3U04_RS06995	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
D3U04_RS07020	COG0613	PHP domain protein
D3U04_RS07025	COG0789	Transcriptional regulator
D3U04_RS07045	COG1959	2 iron, 2 sulfur cluster binding
D3U04_RS07045	COG1295	ribonuclease BN
D3U04_RS07060	COG1960	acyl-CoA dehydrogenase activity
D3U04_RS07085	COG0776	regulation of translation
D3U04_RS07090	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
D3U04_RS07110	COG0737	Belongs to the 5'-nucleotidase family
D3U04_RS07185	COG0318	PFAM AMP-dependent synthetase and ligase
D3U04_RS07215	COG0210	DNA helicase
D3U04_RS07220	COG2308	Evidence 4 Homologs of previously reported genes of
D3U04_RS07220	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
D3U04_RS07230	COG0121	glutamine amidotransferase
D3U04_RS07240	COG1960	acyl-CoA dehydrogenase activity
D3U04_RS07250	COG1309	transcriptional regulator
D3U04_RS07270	COG0318	PFAM AMP-dependent synthetase and ligase
D3U04_RS07280	COG1024	Enoyl-CoA hydratase
D3U04_RS07290	COG2272	Belongs to the type-B carboxylesterase lipase family
D3U04_RS07295	COG0577	efflux transmembrane transporter activity
D3U04_RS07295	COG1136	(ABC) transporter
D3U04_RS07300	COG0577	efflux transmembrane transporter activity
D3U04_RS07300	COG1136	(ABC) transporter
D3U04_RS07315	COG0745	RESPONSE REGULATOR receiver
D3U04_RS07320	COG2205	protein histidine kinase activity
D3U04_RS07355	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
D3U04_RS07400	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
D3U04_RS07425	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
D3U04_RS07435	COG0544	peptidyl-prolyl cis-trans isomerase activity
D3U04_RS07450	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
D3U04_RS07455	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
D3U04_RS07460	COG2124	cytochrome p450
D3U04_RS07465	COG2508	Transcriptional regulator
D3U04_RS07480	COG2409	Drug exporters of the RND superfamily
D3U04_RS07505	COG1012	belongs to the aldehyde dehydrogenase family
D3U04_RS07580	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
D3U04_RS07585	COG1028	Short-chain dehydrogenase reductase Sdr
D3U04_RS07625	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
D3U04_RS07630	COG1492	cobalamin metabolic process
D3U04_RS07715	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D3U04_RS07745	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
D3U04_RS07750	COG1797	cobyrinic acid a,c-diamide synthase activity
D3U04_RS07755	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
D3U04_RS07770	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
D3U04_RS07805	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
D3U04_RS07810	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
D3U04_RS07810	COG1648	precorrin-2 dehydrogenase activity
D3U04_RS07825	COG0629	single-stranded DNA binding
D3U04_RS07860	COG2271	Major facilitator Superfamily
D3U04_RS07875	COG0668	transmembrane transport
D3U04_RS07895	COG2226	methyltransferase
D3U04_RS07900	COG1505	serine-type exopeptidase activity
D3U04_RS07920	COG0662	Cupin 2, conserved barrel domain protein
D3U04_RS07920	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
D3U04_RS07930	COG0129	dihydroxy-acid dehydratase activity
D3U04_RS07955	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
D3U04_RS07960	COG0310	cobalt ion transport
D3U04_RS07970	COG1122	ATPase activity
D3U04_RS07985	COG0698	ribose 5-phosphate isomerase
D3U04_RS07995	COG2205	protein histidine kinase activity
D3U04_RS08000	COG1012	belongs to the aldehyde dehydrogenase family
D3U04_RS08015	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D3U04_RS08030	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
D3U04_RS08060	COG2367	Beta-lactamase
D3U04_RS08075	COG0174	glutamine synthetase
D3U04_RS08100	COG0542	response to heat
D3U04_RS08135	COG1959	2 iron, 2 sulfur cluster binding
D3U04_RS08150	COG1472	Belongs to the glycosyl hydrolase 3 family
D3U04_RS08160	COG1764	response to oxidative stress
D3U04_RS08195	COG1201	RNA secondary structure unwinding
D3U04_RS08225	COG2815	serine threonine protein kinase
D3U04_RS08225	COG0515	serine threonine protein kinase
D3U04_RS08250	COG1609	Transcriptional regulator
D3U04_RS08255	COG0183	Belongs to the thiolase family
D3U04_RS08270	COG1960	acyl-CoA dehydrogenase activity
D3U04_RS08275	COG1960	acyl-CoA dehydrogenase activity
D3U04_RS08310	COG2315	Protein conserved in bacteria
D3U04_RS08315	COG1595	DNA-templated transcription, initiation
D3U04_RS08345	COG2205	protein histidine kinase activity
D3U04_RS08350	COG0745	RESPONSE REGULATOR receiver
D3U04_RS08425	COG3250	beta-galactosidase activity
D3U04_RS08435	COG0673	inositol 2-dehydrogenase activity
D3U04_RS08445	COG0395	ABC-type sugar transport system, permease component
D3U04_RS08450	COG1175	transmembrane transport
D3U04_RS08465	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
D3U04_RS08470	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
D3U04_RS08475	COG4948	Mandelate Racemase Muconate Lactonizing
D3U04_RS08490	COG2755	lipolytic protein G-D-S-L family
D3U04_RS08490	COG0657	acetylesterase activity
D3U04_RS08495	COG0673	inositol 2-dehydrogenase activity
D3U04_RS08615	COG1597	lipid kinase activity
D3U04_RS08715	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
D3U04_RS08735	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
D3U04_RS08750	COG0544	peptidyl-prolyl cis-trans isomerase activity
D3U04_RS08755	COG0740	serine-type endopeptidase activity
D3U04_RS08760	COG0740	serine-type endopeptidase activity
D3U04_RS08765	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
D3U04_RS08770	COG2197	response regulator
D3U04_RS08780	COG2197	response regulator
D3U04_RS08795	COG0525	valine-tRNA ligase activity
D3U04_RS08800	COG0285	dihydrofolate synthase activity
D3U04_RS08810	COG0105	UTP biosynthetic process
D3U04_RS08830	COG0768	penicillin binding
D3U04_RS08835	COG0772	Belongs to the SEDS family
D3U04_RS08850	COG1530	ribonuclease E activity
D3U04_RS08855	COG0261	This protein binds to 23S rRNA in the presence of protein L20
D3U04_RS08860	COG0211	Belongs to the bacterial ribosomal protein bL27 family
D3U04_RS08865	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
D3U04_RS08870	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
D3U04_RS08875	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
D3U04_RS08890	COG0431	NADPH-dependent FMN reductase
D3U04_RS08895	COG0477	Major facilitator Superfamily
D3U04_RS08900	COG0501	Belongs to the peptidase M48B family
D3U04_RS08905	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
D3U04_RS08910	COG0799	negative regulation of ribosome biogenesis
D3U04_RS08915	COG0406	alpha-ribazole phosphatase activity
D3U04_RS08955	COG1683	Conserved Protein
D3U04_RS08960	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
D3U04_RS08965	COG4221	oxidoreductase activity
D3U04_RS08980	COG0577	efflux transmembrane transporter activity
D3U04_RS08980	COG1136	(ABC) transporter
D3U04_RS08985	COG1136	(ABC) transporter
D3U04_RS08985	COG0577	efflux transmembrane transporter activity
D3U04_RS09055	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
D3U04_RS09080	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
D3U04_RS09160	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
D3U04_RS09170	COG1595	DNA-templated transcription, initiation
D3U04_RS09190	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
D3U04_RS09225	COG0495	leucyl-tRNA aminoacylation
D3U04_RS09235	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
D3U04_RS09245	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
D3U04_RS09250	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
D3U04_RS09260	COG0702	epimerase
D3U04_RS09265	COG0656	L-ascorbic acid biosynthetic process
D3U04_RS09285	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
D3U04_RS09290	COG0464	growth
D3U04_RS09300	COG1984	allophanate hydrolase subunit 2
D3U04_RS09305	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
D3U04_RS09310	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
D3U04_RS09315	COG4336	lyase activity
D3U04_RS09390	COG3903	Transcriptional regulator
D3U04_RS09390	COG3629	intracellular signal transduction
D3U04_RS09410	COG2770	Histidine kinase
D3U04_RS09410	COG2208	phosphoserine phosphatase activity
D3U04_RS09415	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
D3U04_RS09425	COG3022	response to hydroperoxide
D3U04_RS09440	COG0531	amino acid
D3U04_RS09470	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
D3U04_RS09505	COG2011	ABC-type metal ion transport system permease component
D3U04_RS09640	COG1674	ftsk spoiiie
D3U04_RS09715	COG1111	helicase
D3U04_RS09715	COG1205	dead DEAH box helicase
D3U04_RS09720	COG1366	Belongs to the anti-sigma-factor antagonist family
D3U04_RS09725	COG2172	sigma factor antagonist activity
D3U04_RS09745	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
D3U04_RS09750	COG2226	methyltransferase
D3U04_RS09760	COG2062	phosphohistidine phosphatase, SixA
D3U04_RS09765	COG0640	Transcriptional regulator
D3U04_RS09775	COG0560	Phosphoserine phosphatase
D3U04_RS09775	COG3830	Belongs to the UPF0237 family
D3U04_RS09795	COG1714	RDD family
D3U04_RS09805	COG1119	ATPase activity
D3U04_RS09825	COG1262	PFAM Formylglycine-generating sulfatase enzyme
D3U04_RS09830	COG0243	molybdopterin cofactor binding
D3U04_RS09850	COG3764	Sortase (surface protein transpeptidase)
D3U04_RS09870	COG1324	tolerance protein
D3U04_RS09880	COG1104	cysteine desulfurase activity
D3U04_RS09885	COG2843	Capsule synthesis protein
D3U04_RS09895	COG0789	Transcriptional regulator
D3U04_RS09895	COG4978	Transcriptional regulator
D3U04_RS09940	COG1309	transcriptional regulator
D3U04_RS09955	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
D3U04_RS09965	COG3339	Conserved Protein
D3U04_RS09985	COG0318	PFAM AMP-dependent synthetase and ligase
D3U04_RS09990	COG2409	Drug exporters of the RND superfamily
D3U04_RS10155	COG1819	glycosyl
D3U04_RS10160	COG0477	Major facilitator Superfamily
D3U04_RS10165	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
D3U04_RS10165	COG3321	synthase
D3U04_RS10205	COG5002	protein histidine kinase activity
D3U04_RS10215	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
D3U04_RS10215	COG2226	methyltransferase
D3U04_RS10215	COG0596	Alpha beta hydrolase
D3U04_RS10220	COG1595	DNA-templated transcription, initiation
D3U04_RS10225	COG0318	PFAM AMP-dependent synthetase and ligase
D3U04_RS10245	COG1024	Enoyl-CoA hydratase
D3U04_RS10260	COG3903	Transcriptional regulator
D3U04_RS10260	COG3629	intracellular signal transduction
D3U04_RS10310	COG1122	ATPase activity
D3U04_RS10320	COG1930	Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import
D3U04_RS10325	COG0310	cobalt ion transport
D3U04_RS10335	COG1742	UPF0060 membrane protein
D3U04_RS10340	COG0726	polysaccharide deacetylase
D3U04_RS10355	COG0515	serine threonine protein kinase
D3U04_RS10385	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
D3U04_RS10440	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
D3U04_RS10455	COG1136	(ABC) transporter
D3U04_RS10515	COG4566	intracellular signal transduction
D3U04_RS10550	COG0318	PFAM AMP-dependent synthetase and ligase
D3U04_RS10600	COG1253	flavin adenine dinucleotide binding
D3U04_RS10615	COG2130	NADP-dependent
D3U04_RS10635	COG0124	histidyl-tRNA synthetase
D3U04_RS10640	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D3U04_RS10650	COG1804	L-carnitine dehydratase bile acid-inducible protein F
D3U04_RS10655	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
D3U04_RS10710	COG3831	ATPase activity
D3U04_RS10715	COG3831	ATPase activity
D3U04_RS10720	COG3831	ATPase activity
D3U04_RS10735	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
D3U04_RS10745	COG2111	Na H antiporter
D3U04_RS10745	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
D3U04_RS10750	COG1006	Multisubunit Na H antiporter MnhC subunit
D3U04_RS10755	COG0651	ATP synthesis coupled electron transport
D3U04_RS10765	COG2212	antiporter activity
D3U04_RS10770	COG1320	monovalent cation:proton antiporter activity
D3U04_RS10805	COG2154	pterin-4-alpha-carbinolamine dehydratase
D3U04_RS10810	COG2154	pterin-4-alpha-carbinolamine dehydratase
D3U04_RS10830	COG2197	response regulator
D3U04_RS10835	COG0477	Major facilitator Superfamily
D3U04_RS10845	COG2132	Multicopper oxidase
D3U04_RS10880	COG1028	Short-chain dehydrogenase reductase Sdr
D3U04_RS10885	COG1024	Enoyl-CoA hydratase
D3U04_RS10890	COG1960	acyl-CoA dehydrogenase activity
D3U04_RS10895	COG1960	acyl-CoA dehydrogenase activity
D3U04_RS10910	COG1309	transcriptional regulator
D3U04_RS10915	COG1131	(ABC) transporter
D3U04_RS10920	COG3559	Exporter of polyketide antibiotics
D3U04_RS10945	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
D3U04_RS10960	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
D3U04_RS11010	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
D3U04_RS11015	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
D3U04_RS11025	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
D3U04_RS11050	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D3U04_RS11055	COG5297	Belongs to the glycosyl hydrolase family 6
D3U04_RS11065	COG4733	cellulase activity
D3U04_RS11065	COG5297	Belongs to the glycosyl hydrolase family 6
D3U04_RS11090	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
D3U04_RS11105	COG0395	ABC-type sugar transport system, permease component
D3U04_RS11140	COG1653	transport
D3U04_RS11145	COG1175	transmembrane transport
D3U04_RS11180	COG0443	Heat shock 70 kDa protein
D3U04_RS11195	COG4608	Belongs to the ABC transporter superfamily
D3U04_RS11205	COG0601	transmembrane transport
D3U04_RS11210	COG0747	negative chemotaxis
D3U04_RS11220	COG1366	Belongs to the anti-sigma-factor antagonist family
D3U04_RS11225	COG0596	Alpha beta hydrolase
D3U04_RS11230	COG1215	transferase activity, transferring glycosyl groups
D3U04_RS11235	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
D3U04_RS11260	COG1960	acyl-CoA dehydrogenase activity
D3U04_RS11285	COG0714	Associated with various cellular activities
D3U04_RS11290	COG3552	Protein containing von Willebrand factor type A (VWA) domain
D3U04_RS11320	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D3U04_RS11340	COG1754	DNA topoisomerase type I activity
D3U04_RS11340	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
D3U04_RS11345	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
D3U04_RS11350	COG0470	DNA polymerase III
D3U04_RS11355	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
D3U04_RS11370	COG1774	PSP1 C-terminal conserved region
D3U04_RS11410	COG0791	NLP P60 protein
D3U04_RS11410	COG3883	PFAM NLP P60 protein
D3U04_RS11415	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
D3U04_RS11420	COG2027	D-alanyl-D-alanine carboxypeptidase
D3U04_RS11430	COG0037	tRNA processing
D3U04_RS11445	COG0302	gtp cyclohydrolase
D3U04_RS11450	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
D3U04_RS11460	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
D3U04_RS11465	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
D3U04_RS11480	COG0649	NAD binding
D3U04_RS11500	COG4585	Histidine kinase
D3U04_RS11505	COG2197	response regulator
D3U04_RS11510	COG1136	(ABC) transporter
D3U04_RS11525	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
D3U04_RS11530	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
D3U04_RS11535	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
D3U04_RS11545	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
D3U04_RS11555	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
D3U04_RS11565	COG0791	NLP P60 protein
D3U04_RS11570	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
D3U04_RS11610	COG1082	Xylose isomerase domain protein TIM barrel
D3U04_RS11655	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
D3U04_RS11660	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
D3U04_RS11670	COG1082	Xylose isomerase domain protein TIM barrel
D3U04_RS11675	COG1309	transcriptional regulator
D3U04_RS11690	COG1316	TRANSCRIPTIONal
D3U04_RS11695	COG0506	proline dehydrogenase activity
D3U04_RS11700	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
D3U04_RS11715	COG1136	(ABC) transporter
D3U04_RS11720	COG1136	(ABC) transporter
D3U04_RS11720	COG0577	efflux transmembrane transporter activity
D3U04_RS11730	COG0123	including yeast histone deacetylase and acetoin utilization protein
D3U04_RS11760	COG0560	Phosphoserine phosphatase
D3U04_RS11765	COG1595	DNA-templated transcription, initiation
D3U04_RS11780	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
D3U04_RS11785	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
D3U04_RS11790	COG0181	hydroxymethylbilane synthase activity
D3U04_RS11795	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
D3U04_RS11795	COG1648	precorrin-2 dehydrogenase activity
D3U04_RS11800	COG0113	porphobilinogen synthase activity
D3U04_RS11810	COG0515	serine threonine protein kinase
D3U04_RS11810	COG2815	serine threonine protein kinase
D3U04_RS11815	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
D3U04_RS11820	COG0583	DNA-binding transcription factor activity
D3U04_RS11830	COG0406	alpha-ribazole phosphatase activity
D3U04_RS11835	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D3U04_RS11840	COG0785	Cytochrome C biogenesis protein
D3U04_RS11845	COG1333	cytochrome c biogenesis protein
D3U04_RS11850	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
D3U04_RS11900	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D3U04_RS11905	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D3U04_RS11910	COG0649	NAD binding
D3U04_RS11925	COG1034	ATP synthesis coupled electron transport
D3U04_RS11930	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
D3U04_RS11935	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D3U04_RS11950	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
D3U04_RS11965	COG0142	geranyltranstransferase activity
D3U04_RS11990	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
D3U04_RS12000	COG1396	sequence-specific DNA binding
D3U04_RS12045	COG0431	NADPH-dependent FMN reductase
D3U04_RS12075	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
D3U04_RS12080	COG1013	pyruvate-flavodoxin oxidoreductase activity
D3U04_RS12085	COG0674	pyruvate-flavodoxin oxidoreductase activity
D3U04_RS12085	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
D3U04_RS12105	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D3U04_RS12120	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D3U04_RS12125	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
D3U04_RS12130	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D3U04_RS12155	COG1007	ATP synthesis coupled electron transport
D3U04_RS12160	COG0501	Belongs to the peptidase M48B family
D3U04_RS12210	COG2442	InterPro IPR007367
D3U04_RS12530	COG1666	GTP binding
D3U04_RS12570	COG2188	Transcriptional regulator
D3U04_RS12595	COG1262	PFAM Formylglycine-generating sulfatase enzyme
D3U04_RS12605	COG4585	Histidine kinase
D3U04_RS12610	COG2197	response regulator
D3U04_RS12625	COG1960	acyl-CoA dehydrogenase activity
D3U04_RS12655	COG0267	Belongs to the bacterial ribosomal protein bL33 family
D3U04_RS12660	COG2030	dehydratase
D3U04_RS12670	COG0812	UDP-N-acetylmuramate dehydrogenase activity
D3U04_RS12680	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
D3U04_RS12685	COG0436	Aminotransferase
D3U04_RS12695	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
D3U04_RS12705	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
D3U04_RS12710	COG0081	regulation of translation
D3U04_RS12725	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
D3U04_RS12730	COG0222	ribosome binding
D3U04_RS12740	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
D3U04_RS12745	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
D3U04_RS12790	COG0085	RNA polymerase activity
D3U04_RS12795	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
D3U04_RS12815	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
D3U04_RS12820	COG0049	tRNA binding
D3U04_RS12825	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
D3U04_RS12830	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
D3U04_RS12835	COG0051	transcription antitermination factor activity, RNA binding
D3U04_RS12840	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
D3U04_RS12845	COG0088	Forms part of the polypeptide exit tunnel
D3U04_RS12850	COG0089	rRNA binding
D3U04_RS12855	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
D3U04_RS12860	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
D3U04_RS12865	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
D3U04_RS12870	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
D3U04_RS12875	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
D3U04_RS12880	COG0255	Belongs to the universal ribosomal protein uL29 family
D3U04_RS12885	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
D3U04_RS12890	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
D3U04_RS12895	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
D3U04_RS12905	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
D3U04_RS12915	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
D3U04_RS12920	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
D3U04_RS12925	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
D3U04_RS12930	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
D3U04_RS12935	COG1841	ribosomal large subunit assembly
D3U04_RS12940	COG0200	Binds to the 23S rRNA
D3U04_RS12950	COG0563	adenylate kinase activity
D3U04_RS12965	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
D3U04_RS12975	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
D3U04_RS12980	COG0257	Belongs to the bacterial ribosomal protein bL36 family
D3U04_RS12985	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
D3U04_RS12990	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
D3U04_RS12995	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
D3U04_RS13000	COG0202	RNA polymerase activity
D3U04_RS13005	COG0203	ribosomal protein L17
D3U04_RS13010	COG0101	tRNA pseudouridine synthase activity
D3U04_RS13025	COG2340	Cysteine-rich secretory protein family
D3U04_RS13030	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
D3U04_RS13035	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
D3U04_RS13040	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
D3U04_RS13080	COG3831	ATPase activity
D3U04_RS13085	COG1072	(Pantothenic acid kinase))
D3U04_RS13090	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
D3U04_RS13115	COG0736	holo-[acyl-carrier-protein] synthase activity
D3U04_RS13125	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
D3U04_RS13135	COG0802	atpase or kinase
D3U04_RS13145	COG1214	PFAM Peptidase M22, glycoprotease
D3U04_RS13145	COG0456	acetyltransferase
D3U04_RS13150	COG0456	acetyltransferase
D3U04_RS13155	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
D3U04_RS13175	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
D3U04_RS13180	COG0459	protein refolding
D3U04_RS13185	COG1595	DNA-templated transcription, initiation
D3U04_RS13205	COG0516	GMP reductase activity
D3U04_RS13210	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
D3U04_RS13215	COG1012	belongs to the aldehyde dehydrogenase family
D3U04_RS13225	COG0519	Catalyzes the synthesis of GMP from XMP
D3U04_RS13225	COG0518	GMP synthase (glutamine-hydrolyzing) activity
D3U04_RS13235	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
D3U04_RS13240	COG0450	alkyl hydroperoxide reductase
D3U04_RS13265	COG0438	transferase activity, transferring glycosyl groups
D3U04_RS13275	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
D3U04_RS13310	COG1301	dicarboxylic acid transport
D3U04_RS13325	COG2197	response regulator
D3U04_RS13330	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
D3U04_RS13360	COG1461	Dihydroxyacetone kinase
D3U04_RS13365	COG2376	Dihydroxyacetone kinase
D3U04_RS13385	COG0045	succinate-CoA ligase (ADP-forming) activity
D3U04_RS13410	COG0138	bifunctional purine biosynthesis protein purh
D3U04_RS13415	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
D3U04_RS13435	COG0039	L-malate dehydrogenase activity
D3U04_RS13440	COG0326	Molecular chaperone. Has ATPase activity
D3U04_RS13450	COG0402	S-adenosylhomocysteine deaminase activity
D3U04_RS13455	COG1846	Transcriptional regulator
D3U04_RS13460	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
D3U04_RS13465	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
D3U04_RS13470	COG0180	Tryptophanyl-tRNA synthetase
D3U04_RS13485	COG1686	Belongs to the peptidase S11 family
D3U04_RS13490	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
D3U04_RS13495	COG1473	amidohydrolase
D3U04_RS13495	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
D3U04_RS13505	COG1028	Short-chain dehydrogenase reductase Sdr
D3U04_RS13560	COG1136	(ABC) transporter
D3U04_RS13615	COG1028	Short-chain dehydrogenase reductase Sdr
D3U04_RS13620	COG1079	Belongs to the binding-protein-dependent transport system permease family
D3U04_RS13625	COG4603	Belongs to the binding-protein-dependent transport system permease family
D3U04_RS13630	COG3845	ABC transporter
D3U04_RS13635	COG1744	ABC transporter substrate-binding protein PnrA-like
D3U04_RS13650	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
D3U04_RS13660	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
D3U04_RS13700	COG0697	spore germination
D3U04_RS13725	COG2197	response regulator
D3U04_RS13730	COG4770	biotin carboxylase activity
D3U04_RS13805	COG1674	ftsk spoiiie
D3U04_RS13890	COG1432	Conserved Protein
D3U04_RS13900	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
D3U04_RS13905	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
D3U04_RS13915	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
D3U04_RS13965	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
D3U04_RS14005	COG0745	RESPONSE REGULATOR receiver
D3U04_RS14010	COG2205	protein histidine kinase activity
D3U04_RS14025	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
D3U04_RS14030	COG1832	CoA-binding protein
D3U04_RS14035	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
D3U04_RS14045	COG1316	TRANSCRIPTIONal
D3U04_RS14065	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
D3U04_RS14095	COG1215	transferase activity, transferring glycosyl groups
D3U04_RS14100	COG3973	AAA domain
D3U04_RS14115	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
D3U04_RS14135	COG3119	arylsulfatase activity
D3U04_RS14165	COG1216	Glycosyl transferase, family 2
D3U04_RS14180	COG2089	acid synthase
D3U04_RS14185	COG1083	cytidylyl-transferase
D3U04_RS14190	COG3594	Acyltransferase
D3U04_RS14205	COG0463	Glycosyl transferase, family 2
D3U04_RS14215	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
D3U04_RS14220	COG3594	Acyltransferase
D3U04_RS14225	COG1316	TRANSCRIPTIONal
D3U04_RS14245	COG0438	transferase activity, transferring glycosyl groups
D3U04_RS14275	COG2124	cytochrome p450
D3U04_RS14315	COG3118	belongs to the thioredoxin family
D3U04_RS14325	COG2226	methyltransferase
D3U04_RS14330	COG0438	transferase activity, transferring glycosyl groups
D3U04_RS14335	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
D3U04_RS14345	COG0583	DNA-binding transcription factor activity
D3U04_RS14350	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
D3U04_RS14360	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
D3U04_RS14360	COG0778	Nitroreductase
D3U04_RS14365	COG0391	Required for morphogenesis under gluconeogenic growth conditions
D3U04_RS14405	COG2835	tetraacyldisaccharide 4'-kinase activity
D3U04_RS14410	COG2222	sugar isomerase
D3U04_RS14420	COG4585	Histidine kinase
D3U04_RS14425	COG2197	response regulator
D3U04_RS14435	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
D3U04_RS14440	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
D3U04_RS14450	COG1309	transcriptional regulator
D3U04_RS14455	COG0667	Aldo Keto reductase
D3U04_RS14490	COG0714	Associated with various cellular activities
D3U04_RS14515	COG0745	RESPONSE REGULATOR receiver
D3U04_RS14525	COG5401	PFAM Sporulation and spore germination
D3U04_RS14530	COG1040	competence protein
D3U04_RS14535	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
D3U04_RS14545	COG3214	Protein conserved in bacteria
D3U04_RS14555	COG0653	protein targeting
D3U04_RS14565	COG1263	PTS System
D3U04_RS14570	COG2188	Transcriptional regulator
D3U04_RS14575	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
D3U04_RS14580	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
D3U04_RS14585	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D3U04_RS14600	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
D3U04_RS14605	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
D3U04_RS14610	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
D3U04_RS14615	COG1472	Belongs to the glycosyl hydrolase 3 family
D3U04_RS14625	COG1737	Transcriptional regulator
D3U04_RS14630	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
D3U04_RS14635	COG1960	acyl-CoA dehydrogenase activity
D3U04_RS14640	COG1011	Hydrolase
D3U04_RS14650	COG1012	belongs to the aldehyde dehydrogenase family
D3U04_RS14660	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
D3U04_RS14665	COG0791	NLP P60 protein
D3U04_RS14665	COG0741	lytic transglycosylase activity
D3U04_RS14675	COG2902	Dehydrogenase
D3U04_RS14690	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
D3U04_RS14705	COG2884	Cell division ATP-binding protein ftsE
D3U04_RS14720	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
D3U04_RS14745	COG1960	acyl-CoA dehydrogenase activity
D3U04_RS14760	COG1215	transferase activity, transferring glycosyl groups
D3U04_RS14780	COG0500	methyltransferase
D3U04_RS14790	COG2070	2-Nitropropane dioxygenase
D3U04_RS14810	COG1024	Enoyl-CoA hydratase
D3U04_RS14830	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
D3U04_RS14835	COG0318	PFAM AMP-dependent synthetase and ligase
D3U04_RS14840	COG1846	Transcriptional regulator
D3U04_RS14845	COG1028	Short-chain dehydrogenase reductase Sdr
D3U04_RS14860	COG0154	amidase activity
D3U04_RS14895	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
D3U04_RS14895	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
D3U04_RS14900	COG0515	serine threonine protein kinase
D3U04_RS14905	COG0515	serine threonine protein kinase
D3U04_RS14910	COG0515	serine threonine protein kinase
D3U04_RS14915	COG2197	response regulator
D3U04_RS14920	COG4585	Histidine kinase
D3U04_RS14925	COG0028	Belongs to the TPP enzyme family
D3U04_RS14930	COG1309	transcriptional regulator
D3U04_RS14945	COG2211	Major facilitator Superfamily
D3U04_RS14950	COG1686	Belongs to the peptidase S11 family
D3U04_RS14980	COG0018	arginyl-trna synthetase
D3U04_RS15010	COG0596	Alpha beta hydrolase
D3U04_RS15040	COG3321	synthase
D3U04_RS15040	COG0604	alcohol dehydrogenase
D3U04_RS15055	COG2207	Transcriptional regulator
D3U04_RS15055	COG3708	Transcriptional regulator
D3U04_RS15130	COG1028	Short-chain dehydrogenase reductase Sdr
D3U04_RS15180	COG0277	FAD linked oxidase domain protein
D3U04_RS15185	COG0477	Major facilitator Superfamily
D3U04_RS15195	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
D3U04_RS15200	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
D3U04_RS15270	COG4941	Belongs to the sigma-70 factor family
D3U04_RS15290	COG1595	DNA-templated transcription, initiation
D3U04_RS15325	COG0019	diaminopimelate decarboxylase activity
D3U04_RS15330	COG0460	homoserine dehydrogenase
D3U04_RS15335	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
D3U04_RS15340	COG0083	homoserine kinase activity
D3U04_RS15360	COG0254	rRNA binding
D3U04_RS15365	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
D3U04_RS15370	COG2890	protein-(glutamine-N5) methyltransferase activity
D3U04_RS15385	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
D3U04_RS15405	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
D3U04_RS15410	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
D3U04_RS15415	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
D3U04_RS15420	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
D3U04_RS15425	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
D3U04_RS15430	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
D3U04_RS15435	COG0355	proton-transporting ATP synthase activity, rotational mechanism
D3U04_RS15475	COG1994	Peptidase M50
D3U04_RS15505	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
D3U04_RS15520	COG0456	acetyltransferase
D3U04_RS15535	COG1250	3-hydroxyacyl-CoA dehydrogenase
D3U04_RS15570	COG2885	chlorophyll binding
D3U04_RS15585	COG0183	Belongs to the thiolase family
D3U04_RS15600	COG2814	Major facilitator Superfamily
D3U04_RS15610	COG1136	(ABC) transporter
D3U04_RS15620	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
D3U04_RS15640	COG1678	Uncharacterized ACR, COG1678
D3U04_RS15660	COG3265	gluconokinase activity
D3U04_RS15665	COG1335	isochorismatase
D3U04_RS15675	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
D3U04_RS15715	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
D3U04_RS15720	COG1234	tRNA 3'-trailer cleavage
D3U04_RS15725	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
D3U04_RS15730	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
D3U04_RS15735	COG0222	ribosome binding
D3U04_RS15775	COG1486	melibiose metabolic process
D3U04_RS15780	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D3U04_RS15845	COG1496	oxidoreductase activity
D3U04_RS15855	COG1760	l-serine dehydratase
D3U04_RS15860	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
D3U04_RS15865	COG0509	glycine decarboxylation via glycine cleavage system
D3U04_RS15870	COG0404	The glycine cleavage system catalyzes the degradation of glycine
D3U04_RS15885	COG0750	zinc metalloprotease
D3U04_RS15930	COG1309	transcriptional regulator
D3U04_RS15940	COG1309	transcriptional regulator
D3U04_RS15955	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
D3U04_RS15960	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
D3U04_RS16010	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
D3U04_RS16030	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
D3U04_RS16075	COG2018	Roadblock/LC7 domain
D3U04_RS16115	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
D3U04_RS16130	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
D3U04_RS16180	COG0477	Major facilitator Superfamily
D3U04_RS16200	COG0437	4 iron, 4 sulfur cluster binding
D3U04_RS16215	COG0517	IMP dehydrogenase activity
D3U04_RS16230	COG2409	Drug exporters of the RND superfamily
D3U04_RS16250	COG2197	response regulator
D3U04_RS16265	COG3237	CsbD-like
D3U04_RS16295	COG0210	DNA helicase
D3U04_RS16305	COG2226	methyltransferase
D3U04_RS16325	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
D3U04_RS16360	COG1946	Acyl-CoA thioesterase
D3U04_RS16375	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
D3U04_RS16415	COG1615	UPF0182 protein
D3U04_RS16430	COG3480	Lon protease (S16) C-terminal proteolytic domain
D3U04_RS16465	COG1028	Short-chain dehydrogenase reductase Sdr
D3U04_RS16475	COG0579	oxidoreductase
D3U04_RS16485	COG0483	inositol monophosphate 1-phosphatase activity
D3U04_RS16490	COG0183	Belongs to the thiolase family
D3U04_RS16510	COG0277	FAD linked oxidase domain protein
D3U04_RS16515	COG0515	serine threonine protein kinase
D3U04_RS16515	COG2815	serine threonine protein kinase
D3U04_RS16525	COG4221	oxidoreductase activity
D3U04_RS16535	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
D3U04_RS16550	COG2135	peptidase activity
D3U04_RS16565	COG1595	DNA-templated transcription, initiation
D3U04_RS16570	COG5662	AntiSigma factor
D3U04_RS16575	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
D3U04_RS16580	COG2199	diguanylate cyclase activity
D3U04_RS16580	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
D3U04_RS16590	COG0439	Biotin carboxylase
D3U04_RS16595	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
D3U04_RS16610	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
D3U04_RS16615	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
D3U04_RS16620	COG2188	Transcriptional regulator
D3U04_RS16640	COG1597	lipid kinase activity
D3U04_RS16655	COG2172	sigma factor antagonist activity
D3U04_RS16685	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D3U04_RS16690	COG0765	amino acid transport
D3U04_RS16705	COG1695	Transcriptional regulator
D3U04_RS16720	COG0508	dehydrogenase complex catalyzes the overall conversion of
D3U04_RS16720	COG0567	Dehydrogenase, E1 component
D3U04_RS16730	COG0435	Glutathione S-transferase
D3U04_RS16740	COG1028	Short-chain dehydrogenase reductase Sdr
D3U04_RS16745	COG1024	Enoyl-CoA hydratase
D3U04_RS16750	COG1940	carbohydrate kinase activity
D3U04_RS16755	COG1129	ABC transporter
D3U04_RS16760	COG1172	Belongs to the binding-protein-dependent transport system permease family
D3U04_RS16815	COG2515	1-aminocyclopropane-1-carboxylate deaminase
D3U04_RS16850	COG2226	methyltransferase
D3U04_RS16855	COG0438	transferase activity, transferring glycosyl groups
D3U04_RS16875	COG0183	Belongs to the thiolase family
D3U04_RS16880	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
D3U04_RS16890	COG1442	glycosyl transferase family 8
D3U04_RS16890	COG1216	Glycosyl transferase, family 2
D3U04_RS16895	COG2124	cytochrome p450
D3U04_RS16900	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
D3U04_RS16940	COG4221	oxidoreductase activity
D3U04_RS16945	COG4266	Belongs to the allantoicase family
D3U04_RS16960	COG1960	acyl-CoA dehydrogenase activity
D3U04_RS16965	COG1960	acyl-CoA dehydrogenase activity
D3U04_RS16975	COG3572	ergothioneine biosynthetic process
D3U04_RS16980	COG1262	PFAM Formylglycine-generating sulfatase enzyme
D3U04_RS16985	COG0121	glutamine amidotransferase
D3U04_RS16990	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
D3U04_RS16995	COG1609	Transcriptional regulator
D3U04_RS17000	COG0517	IMP dehydrogenase activity
D3U04_RS17000	COG1125	glycine betaine transport
D3U04_RS17005	COG1174	glycine betaine transport
D3U04_RS17010	COG1174	glycine betaine transport
D3U04_RS17020	COG1414	Transcriptional regulator
D3U04_RS17025	COG2986	histidine ammonia-lyase
D3U04_RS17030	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
D3U04_RS17035	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D3U04_RS17045	COG1228	amidohydrolase
D3U04_RS17055	COG2197	response regulator
D3U04_RS17065	COG1132	(ABC) transporter
D3U04_RS17080	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
D3U04_RS17085	COG0616	signal peptide processing
D3U04_RS17105	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
D3U04_RS17130	COG2186	Transcriptional regulator
D3U04_RS17165	COG1215	transferase activity, transferring glycosyl groups
D3U04_RS17175	COG0463	Glycosyl transferase, family 2
D3U04_RS17190	COG0366	Alpha amylase catalytic
D3U04_RS17195	COG0058	SHG alpha-glucan phosphorylase activity
D3U04_RS17200	COG4279	zinc finger
D3U04_RS17205	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
D3U04_RS17210	COG4221	oxidoreductase activity
D3U04_RS17220	COG0515	serine threonine protein kinase
D3U04_RS17220	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
D3U04_RS17235	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
D3U04_RS17240	COG0714	Associated with various cellular activities
D3U04_RS17260	COG2223	nitrite transmembrane transporter activity
D3U04_RS17285	COG0482	sulfurtransferase activity
D3U04_RS17305	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
D3U04_RS17325	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
D3U04_RS17330	COG0154	amidase activity
D3U04_RS17335	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
D3U04_RS17340	COG2133	pyrroloquinoline quinone binding
D3U04_RS17350	COG5001	Diguanylate cyclase
D3U04_RS17365	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
D3U04_RS17380	COG0473	3-isopropylmalate dehydrogenase activity
D3U04_RS17385	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
D3U04_RS17390	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
D3U04_RS17410	COG0179	Fumarylacetoacetate (FAA) hydrolase
D3U04_RS17435	COG1556	Lactate utilization protein
D3U04_RS17440	COG1139	Iron-sulfur cluster binding protein
D3U04_RS17445	COG0247	lactate metabolic process
D3U04_RS17450	COG1620	l-lactate permease
D3U04_RS17470	COG3485	protocatechuate 3,4-dioxygenase
D3U04_RS17480	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
D3U04_RS17485	COG2267	carboxylic ester hydrolase activity
D3U04_RS17490	COG1053	succinate dehydrogenase
D3U04_RS17515	COG1028	Short-chain dehydrogenase reductase Sdr
D3U04_RS17555	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
D3U04_RS17565	COG2197	response regulator
D3U04_RS17575	COG0275	rRNA processing
D3U04_RS17585	COG0438	transferase activity, transferring glycosyl groups
D3U04_RS17605	COG1053	succinate dehydrogenase
D3U04_RS17620	COG1960	acyl-CoA dehydrogenase activity
D3U04_RS17630	COG0459	protein refolding
D3U04_RS17635	COG1309	transcriptional regulator
D3U04_RS17650	COG1131	(ABC) transporter
D3U04_RS17665	COG1028	Short-chain dehydrogenase reductase Sdr
D3U04_RS17675	COG0318	PFAM AMP-dependent synthetase and ligase
D3U04_RS17680	COG1960	acyl-CoA dehydrogenase activity
D3U04_RS17690	COG1960	acyl-CoA dehydrogenase activity
D3U04_RS17705	COG1028	Short-chain dehydrogenase reductase Sdr
D3U04_RS17710	COG0183	Belongs to the thiolase family
D3U04_RS17715	COG1028	Short-chain dehydrogenase reductase Sdr
D3U04_RS17720	COG3971	2-oxopent-4-enoate hydratase activity
D3U04_RS17735	COG0358	DNA primase activity
D3U04_RS17770	COG1414	Transcriptional regulator
D3U04_RS17775	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
D3U04_RS17780	COG0066	3-isopropylmalate dehydratase activity
D3U04_RS17790	COG0776	regulation of translation
D3U04_RS17800	COG1920	GTP binding
D3U04_RS17810	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
D3U04_RS17855	COG1262	PFAM Formylglycine-generating sulfatase enzyme
D3U04_RS17860	COG0577	efflux transmembrane transporter activity
D3U04_RS17865	COG1136	(ABC) transporter
D3U04_RS17865	COG0577	efflux transmembrane transporter activity
D3U04_RS17900	COG1959	2 iron, 2 sulfur cluster binding
D3U04_RS17905	COG1017	nitric oxide dioxygenase activity
D3U04_RS17905	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
D3U04_RS17935	COG0351	phosphomethylpyrimidine kinase
D3U04_RS17950	COG0227	Belongs to the bacterial ribosomal protein bL28 family
D3U04_RS17960	COG0742	ribosomal rna small subunit methyltransferase
D3U04_RS17965	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
D3U04_RS17975	COG0333	Belongs to the bacterial ribosomal protein bL32 family
D3U04_RS17980	COG0571	ribonuclease III activity
D3U04_RS17985	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
D3U04_RS17990	COG1254	Belongs to the acylphosphatase family
D3U04_RS18000	COG1196	nuclear chromosome segregation
D3U04_RS18025	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
D3U04_RS18040	COG1837	Belongs to the UPF0109 family
D3U04_RS18045	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
D3U04_RS18060	COG0335	large ribosomal subunit rRNA binding
D3U04_RS18065	COG0681	Belongs to the peptidase S26 family
D3U04_RS18070	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
D3U04_RS18090	COG0792	nuclease activity
D3U04_RS18105	COG0052	Belongs to the universal ribosomal protein uS2 family
D3U04_RS18110	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
D3U04_RS18115	COG0528	UMP kinase activity
D3U04_RS18120	COG0233	cytoplasmic translational termination
D3U04_RS18135	COG0820	rRNA (adenine-C2-)-methyltransferase activity
D3U04_RS18175	COG1012	belongs to the aldehyde dehydrogenase family
D3U04_RS18180	COG3842	ATPase activity
D3U04_RS18190	COG1176	ABC-type spermidine putrescine transport system, permease component I
D3U04_RS18195	COG1177	transmembrane transport
D3U04_RS18200	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D3U04_RS18220	COG0515	serine threonine protein kinase
D3U04_RS18220	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
D3U04_RS18225	COG0475	glutathione-regulated potassium exporter activity
D3U04_RS18230	COG1716	ATPase activity
D3U04_RS18270	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
D3U04_RS18285	COG2154	pterin-4-alpha-carbinolamine dehydratase
D3U04_RS18290	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
D3U04_RS18305	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
D3U04_RS18325	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
D3U04_RS18330	COG0750	zinc metalloprotease
D3U04_RS18335	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
D3U04_RS18365	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
D3U04_RS18410	COG1280	lysine exporter protein (LysE YggA)
D3U04_RS18420	COG1515	deoxyribonuclease V activity
D3U04_RS18440	COG1309	transcriptional regulator
D3U04_RS18450	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
D3U04_RS18485	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
D3U04_RS18490	COG3485	protocatechuate 3,4-dioxygenase
D3U04_RS18495	COG3485	protocatechuate 3,4-dioxygenase
D3U04_RS18500	COG1414	Transcriptional regulator
D3U04_RS18515	COG1126	abc transporter atp-binding protein
D3U04_RS18540	COG1028	Short-chain dehydrogenase reductase Sdr
D3U04_RS18570	COG1960	acyl-CoA dehydrogenase activity
D3U04_RS18610	COG0779	Required for maturation of 30S ribosomal subunits
D3U04_RS18625	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
D3U04_RS18635	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
D3U04_RS18640	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
D3U04_RS18645	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
D3U04_RS18655	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
D3U04_RS18660	COG1185	polyribonucleotide nucleotidyltransferase activity
D3U04_RS18665	COG0612	Peptidase, M16
D3U04_RS18670	COG1950	PFAM Membrane protein of
D3U04_RS18675	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
D3U04_RS18695	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
D3U04_RS18710	COG0477	Major facilitator Superfamily
D3U04_RS18730	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D3U04_RS18750	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
D3U04_RS18755	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
D3U04_RS18760	COG1674	ftsk spoiiie
D3U04_RS18770	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
D3U04_RS18780	COG1058	Belongs to the CinA family
D3U04_RS18780	COG1546	Belongs to the CinA family
D3U04_RS18785	COG1396	sequence-specific DNA binding
D3U04_RS18790	COG0783	Belongs to the Dps family
D3U04_RS18795	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
D3U04_RS18810	COG0395	ABC-type sugar transport system, permease component
D3U04_RS18825	COG1846	Transcriptional regulator
D3U04_RS18825	COG1940	carbohydrate kinase activity
D3U04_RS18830	COG1201	RNA secondary structure unwinding
D3U04_RS18845	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
D3U04_RS18850	COG2137	regulation of response to DNA damage stimulus
D3U04_RS18855	COG1418	mRNA catabolic process
D3U04_RS18865	COG0765	amino acid transport
D3U04_RS18870	COG0765	amino acid transport
D3U04_RS18875	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D3U04_RS18880	COG1126	abc transporter atp-binding protein
D3U04_RS18885	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
D3U04_RS18900	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
D3U04_RS18905	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
D3U04_RS18920	COG1309	transcriptional regulator
D3U04_RS18955	COG0247	lactate metabolic process
D3U04_RS18960	COG0277	FAD linked oxidase domain protein
D3U04_RS18965	COG0277	FAD linked oxidase domain protein
D3U04_RS18970	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
D3U04_RS18975	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
D3U04_RS18980	COG1228	amidohydrolase
D3U04_RS18985	COG1307	EDD domain protein, DegV family
D3U04_RS19010	COG0268	Binds directly to 16S ribosomal RNA
D3U04_RS19015	COG0481	GTPase activity
D3U04_RS19055	COG1420	regulation of RNA biosynthetic process
D3U04_RS19060	COG0484	heat shock protein binding
D3U04_RS19080	COG0537	adenosine 5'-monophosphoramidase activity
D3U04_RS19090	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
D3U04_RS19105	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
D3U04_RS19115	COG1834	amidinotransferase
D3U04_RS19120	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
D3U04_RS19145	COG2124	cytochrome p450
D3U04_RS19160	COG1381	Involved in DNA repair and RecF pathway recombination
D3U04_RS19165	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
D3U04_RS19175	COG1108	ABC-type Mn2 Zn2 transport systems permease components
D3U04_RS19180	COG1121	(ABC) transporter
D3U04_RS19200	COG0423	glycine-tRNA ligase activity
D3U04_RS19210	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
D3U04_RS19210	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
D3U04_RS19235	COG3387	PFAM Glycoside hydrolase 15-related
D3U04_RS19240	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
D3U04_RS19240	COG0574	Belongs to the PEP-utilizing enzyme family
D3U04_RS19250	COG0232	Belongs to the dGTPase family. Type 2 subfamily
D3U04_RS19270	COG1595	DNA-templated transcription, initiation
D3U04_RS19290	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D3U04_RS19295	COG0789	Transcriptional regulator
D3U04_RS19300	COG0829	nickel cation binding
D3U04_RS19305	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
D3U04_RS19315	COG0804	urea catabolic process
D3U04_RS19320	COG0832	Belongs to the urease beta subunit family
D3U04_RS19325	COG0831	urea catabolic process
D3U04_RS19340	COG0358	DNA primase activity
D3U04_RS19345	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
D3U04_RS19355	COG0393	Putative heavy-metal-binding
D3U04_RS19400	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
D3U04_RS19470	COG4977	sequence-specific DNA binding
D3U04_RS19505	COG3386	PFAM SMP-30 Gluconolaconase
D3U04_RS19515	COG1280	lysine exporter protein (LysE YggA)
D3U04_RS19540	COG3275	phosphorelay sensor kinase activity
D3U04_RS19555	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
D3U04_RS19590	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
D3U04_RS19600	COG0559	Belongs to the binding-protein-dependent transport system permease family
D3U04_RS19605	COG0559	Belongs to the binding-protein-dependent transport system permease family
D3U04_RS19630	COG0477	Major facilitator Superfamily
D3U04_RS19645	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
D3U04_RS19655	COG1376	ErfK ybiS ycfS ynhG family protein
D3U04_RS19675	COG1881	PFAM PEBP family protein
D3U04_RS19695	COG0318	PFAM AMP-dependent synthetase and ligase
D3U04_RS19725	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
D3U04_RS19740	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
D3U04_RS19770	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
D3U04_RS19790	COG0531	amino acid
D3U04_RS19795	COG0405	Gamma-glutamyltransferase
D3U04_RS19810	COG1937	Protein conserved in bacteria
D3U04_RS19815	COG0406	alpha-ribazole phosphatase activity
D3U04_RS19825	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
D3U04_RS19830	COG1929	Belongs to the glycerate kinase type-1 family
D3U04_RS19835	COG1529	Aldehyde oxidase and xanthine dehydrogenase
D3U04_RS19845	COG2351	hydroxyisourate hydrolase activity
D3U04_RS19875	COG3336	cytochrome c oxidase
D3U04_RS19880	COG4585	Histidine kinase
D3U04_RS19885	COG2197	response regulator
D3U04_RS19895	COG0318	PFAM AMP-dependent synthetase and ligase
D3U04_RS19900	COG0583	DNA-binding transcription factor activity
D3U04_RS19905	COG0667	Aldo Keto reductase
D3U04_RS19910	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
D3U04_RS19950	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
D3U04_RS19955	COG0477	Major facilitator Superfamily
D3U04_RS19990	COG1674	ftsk spoiiie
D3U04_RS20055	COG2814	Major facilitator Superfamily
D3U04_RS20070	COG0174	glutamine synthetase
D3U04_RS20075	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
D3U04_RS20090	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
D3U04_RS20110	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
D3U04_RS20120	COG0321	lipoyl(octanoyl) transferase activity
D3U04_RS20125	COG3340	Belongs to the peptidase S51 family
D3U04_RS20140	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
D3U04_RS20145	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
D3U04_RS20150	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
D3U04_RS20165	COG0667	Aldo Keto reductase
D3U04_RS20185	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
D3U04_RS20195	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D3U04_RS20210	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
D3U04_RS20215	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
D3U04_RS20225	COG1376	ErfK ybiS ycfS ynhG family protein
D3U04_RS20230	COG0501	Belongs to the peptidase M48B family
D3U04_RS20245	COG0791	NLP P60 protein
D3U04_RS20245	COG1388	LysM domain
D3U04_RS20245	COG3103	Sh3 type 3 domain protein
D3U04_RS20270	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
D3U04_RS20280	COG1845	cytochrome c oxidase, subunit III
D3U04_RS20290	COG0723	plastoquinol--plastocyanin reductase activity
D3U04_RS20295	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
D3U04_RS20300	COG0438	transferase activity, transferring glycosyl groups
D3U04_RS20355	COG1022	Amp-dependent synthetase and ligase
D3U04_RS20360	COG3142	Participates in the control of copper homeostasis
D3U04_RS20375	COG1940	carbohydrate kinase activity
D3U04_RS20420	COG3220	belongs to the UPF0276 family
D3U04_RS20425	COG3220	belongs to the UPF0276 family
D3U04_RS20435	COG0301	tRNA thio-modification
D3U04_RS20445	COG0697	spore germination
D3U04_RS20450	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
D3U04_RS20455	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
D3U04_RS20460	COG3279	Response regulator of the LytR AlgR family
D3U04_RS20470	COG0515	serine threonine protein kinase
D3U04_RS20470	COG2815	serine threonine protein kinase
D3U04_RS20475	COG2022	thiamine diphosphate biosynthetic process
D3U04_RS20500	COG0352	thiamine-phosphate diphosphorylase activity
D3U04_RS20510	COG0142	geranyltranstransferase activity
D3U04_RS20570	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
D3U04_RS20575	COG0540	Belongs to the ATCase OTCase family
D3U04_RS20580	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
D3U04_RS20585	COG0505	Belongs to the CarA family
D3U04_RS20590	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
D3U04_RS20595	COG0543	2 iron, 2 sulfur cluster binding
D3U04_RS20600	COG0167	dihydroorotate dehydrogenase activity
D3U04_RS20605	COG0284	orotidine-5'-phosphate decarboxylase activity
D3U04_RS20615	COG0194	GDP metabolic process
D3U04_RS20620	COG1758	RNA polymerase activity
D3U04_RS20630	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
D3U04_RS20645	COG0242	peptide deformylase activity
D3U04_RS20650	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
D3U04_RS20665	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
D3U04_RS20675	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
D3U04_RS20690	COG3201	nicotinamide mononucleotide transporter
D3U04_RS20695	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
D3U04_RS20695	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
D3U04_RS20700	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
D3U04_RS20705	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
D3U04_RS20720	COG2208	phosphoserine phosphatase activity
D3U04_RS20720	COG2770	Histidine kinase
D3U04_RS20730	COG2837	iron assimilation
D3U04_RS20735	COG2847	Copper chaperone PCu(A)C
D3U04_RS20745	COG1804	L-carnitine dehydratase bile acid-inducible protein F
D3U04_RS20775	COG3608	succinylglutamate desuccinylase aspartoacylase
D3U04_RS20775	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
D3U04_RS20810	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
D3U04_RS20810	COG3608	succinylglutamate desuccinylase aspartoacylase
D3U04_RS20830	COG1304	FMN binding
D3U04_RS20835	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
D3U04_RS20850	COG2233	PERMEase
D3U04_RS20885	COG0542	response to heat
D3U04_RS20890	COG1028	Short-chain dehydrogenase reductase Sdr
D3U04_RS20920	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
D3U04_RS20925	COG1131	(ABC) transporter
D3U04_RS20935	COG4585	Histidine kinase
D3U04_RS20940	COG2197	response regulator
D3U04_RS20960	COG0549	Belongs to the carbamate kinase family
D3U04_RS20990	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
D3U04_RS20995	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
D3U04_RS21000	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
D3U04_RS21005	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
D3U04_RS21020	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D3U04_RS21025	COG0006	proline dipeptidase activity
D3U04_RS21030	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
D3U04_RS21035	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
D3U04_RS21045	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
D3U04_RS21065	COG0714	Associated with various cellular activities
D3U04_RS21070	COG2001	Belongs to the MraZ family
D3U04_RS21075	COG0275	rRNA processing
D3U04_RS21085	COG0768	penicillin binding
D3U04_RS21090	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
D3U04_RS21100	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
D3U04_RS21105	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
D3U04_RS21115	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
D3U04_RS21120	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
D3U04_RS21125	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
D3U04_RS21140	COG1799	cell septum assembly
D3U04_RS21150	COG3599	regulation of cell shape
D3U04_RS21170	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
D3U04_RS21175	COG1872	DUF167
D3U04_RS21225	COG0587	DNA-directed DNA polymerase activity
D3U04_RS21255	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
D3U04_RS21265	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
D3U04_RS21275	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
D3U04_RS21280	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
D3U04_RS21285	COG0131	Imidazoleglycerol-phosphate dehydratase
D3U04_RS21290	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
D3U04_RS21295	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
D3U04_RS21305	COG0107	imidazoleglycerol-phosphate synthase activity
D3U04_RS21325	COG1960	acyl-CoA dehydrogenase activity
D3U04_RS21345	COG1132	(ABC) transporter
D3U04_RS21355	COG1278	Cold shock
D3U04_RS21360	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
D3U04_RS21370	COG0745	RESPONSE REGULATOR receiver
D3U04_RS21380	COG0134	indole-3-glycerol-phosphate synthase activity
D3U04_RS21385	COG0133	tryptophan synthase activity
D3U04_RS21390	COG0159	tryptophan synthase activity
D3U04_RS21425	COG0070	glutamate synthase
D3U04_RS21425	COG0067	glutamate synthase
D3U04_RS21425	COG0069	glutamate synthase activity
D3U04_RS21445	COG0693	protein deglycase activity
D3U04_RS21500	COG2050	protein possibly involved in aromatic compounds catabolism
D3U04_RS21540	COG0556	nucleotide-excision repair
D3U04_RS21555	COG2755	lipolytic protein G-D-S-L family
D3U04_RS21560	COG2070	2-Nitropropane dioxygenase
D3U04_RS21585	COG0504	CTP synthase activity
D3U04_RS21590	COG0494	nUDIX hydrolase
D3U04_RS21605	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
D3U04_RS21610	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
D3U04_RS21620	COG4401	Chorismate mutase type I
D3U04_RS21630	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
D3U04_RS21635	COG1160	GTP binding
D3U04_RS21650	COG0346	lactoylglutathione lyase activity
D3U04_RS21665	COG0725	ABC transporter, periplasmic molybdate-binding protein
D3U04_RS21680	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
D3U04_RS21710	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
D3U04_RS21755	COG0384	phenazine biosynthesis protein PhzF
D3U04_RS21780	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
D3U04_RS21785	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
D3U04_RS21795	COG0517	IMP dehydrogenase activity
D3U04_RS21800	COG2197	response regulator
D3U04_RS21805	COG4585	Histidine kinase
D3U04_RS21815	COG2409	Drug exporters of the RND superfamily
D3U04_RS21825	COG1024	Enoyl-CoA hydratase
D3U04_RS21830	COG0248	Ppx GppA phosphatase
D3U04_RS21850	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
D3U04_RS21860	COG4249	Peptidase C14 caspase catalytic subunit p20
D3U04_RS21860	COG2319	Wd-40 repeat
D3U04_RS21885	COG2124	cytochrome p450
D3U04_RS21910	COG2755	lipolytic protein G-D-S-L family
D3U04_RS21940	COG2116	formate transmembrane transporter activity
D3U04_RS21960	COG3540	Alkaline phosphatase
D3U04_RS21970	COG2318	DinB family
D3U04_RS21990	COG2223	nitrite transmembrane transporter activity
D3U04_RS21995	COG2207	Transcriptional regulator
D3U04_RS22010	COG0596	Alpha beta hydrolase
D3U04_RS22025	COG0657	acetylesterase activity
D3U04_RS22035	COG1846	Transcriptional regulator
D3U04_RS22105	COG4213	ABC transporter substrate-binding protein
D3U04_RS22115	COG4214	carbohydrate transport
D3U04_RS22130	COG0667	Aldo Keto reductase
D3U04_RS22145	COG1643	Atp-dependent helicase
D3U04_RS22200	COG3486	L-lysine 6-monooxygenase (NADPH) activity
D3U04_RS22215	COG1960	acyl-CoA dehydrogenase activity
D3U04_RS22245	COG2183	response to ionizing radiation
D3U04_RS22255	COG0494	nUDIX hydrolase
D3U04_RS22270	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
D3U04_RS22280	COG0784	Response regulator, receiver
D3U04_RS22280	COG5002	protein histidine kinase activity
D3U04_RS22300	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
D3U04_RS22310	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D3U04_RS22335	COG1309	transcriptional regulator
D3U04_RS22345	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
D3U04_RS22365	COG4948	Mandelate Racemase Muconate Lactonizing
D3U04_RS22380	COG1316	TRANSCRIPTIONal
D3U04_RS22390	COG1522	sequence-specific DNA binding
D3U04_RS22410	COG0477	Major facilitator Superfamily
D3U04_RS22465	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
D3U04_RS22470	COG0583	DNA-binding transcription factor activity
D3U04_RS22485	COG1376	ErfK ybiS ycfS ynhG family protein
D3U04_RS22600	COG0358	DNA primase activity
D3U04_RS22660	COG0406	alpha-ribazole phosphatase activity
D3U04_RS22660	COG0494	nUDIX hydrolase
D3U04_RS22695	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
D3U04_RS22745	COG1262	PFAM Formylglycine-generating sulfatase enzyme
D3U04_RS22750	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
D3U04_RS22785	COG1518	maintenance of DNA repeat elements
D3U04_RS22790	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
D3U04_RS22810	COG1309	transcriptional regulator
D3U04_RS22880	COG3693	PFAM glycoside hydrolase, family 10
D3U04_RS22885	COG0604	alcohol dehydrogenase
D3U04_RS22900	COG0596	Alpha beta hydrolase
D3U04_RS22905	COG2409	Drug exporters of the RND superfamily
D3U04_RS22930	COG4941	Belongs to the sigma-70 factor family
D3U04_RS22935	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
D3U04_RS22950	COG2226	methyltransferase
D3U04_RS22955	COG0640	Transcriptional regulator
D3U04_RS22960	COG0798	PFAM Bile acid sodium symporter
D3U04_RS22970	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
D3U04_RS22975	COG0640	Transcriptional regulator
D3U04_RS22980	COG2072	flavoprotein involved in K transport
D3U04_RS22985	COG0640	Transcriptional regulator
D3U04_RS22995	COG1028	Short-chain dehydrogenase reductase Sdr
D3U04_RS23000	COG1309	transcriptional regulator
D3U04_RS23005	COG0667	Aldo Keto reductase
D3U04_RS23080	COG0318	PFAM AMP-dependent synthetase and ligase
D3U04_RS23085	COG1960	acyl-CoA dehydrogenase activity
D3U04_RS23150	COG0302	gtp cyclohydrolase
D3U04_RS23170	COG1595	DNA-templated transcription, initiation
D3U04_RS23175	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
D3U04_RS23190	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D3U04_RS23190	COG0723	plastoquinol--plastocyanin reductase activity
D3U04_RS23215	COG1295	ribonuclease BN
D3U04_RS23220	COG0515	serine threonine protein kinase
D3U04_RS23250	COG0583	DNA-binding transcription factor activity
D3U04_RS23300	COG2160	L-arabinose isomerase activity
D3U04_RS23305	COG1879	ABC-type sugar transport system periplasmic component
D3U04_RS23315	COG1172	Belongs to the binding-protein-dependent transport system permease family
D3U04_RS23320	COG1172	Belongs to the binding-protein-dependent transport system permease family
D3U04_RS23415	COG0464	growth
D3U04_RS23455	COG1864	DNA RNA non-specific endonuclease
D3U04_RS23455	COG3591	Belongs to the peptidase S1B family
D3U04_RS23470	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D3U04_RS23495	COG1063	alcohol dehydrogenase
D3U04_RS23545	COG0535	radical SAM domain protein
D3U04_RS23565	COG1028	Short-chain dehydrogenase reductase Sdr
D3U04_RS23615	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
D3U04_RS23620	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
D3U04_RS23650	COG0513	Belongs to the DEAD box helicase family
D3U04_RS23655	COG1278	Cold shock
D3U04_RS23665	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
D3U04_RS23670	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
D3U04_RS23690	COG1846	Transcriptional regulator
D3U04_RS23750	COG1028	Short-chain dehydrogenase reductase Sdr
D3U04_RS23765	COG2124	cytochrome p450
D3U04_RS23840	COG1335	isochorismatase
D3U04_RS23845	COG1802	Transcriptional regulator
D3U04_RS23850	COG0277	FAD linked oxidase domain protein
D3U04_RS23860	COG1960	acyl-CoA dehydrogenase activity
D3U04_RS23865	COG1960	acyl-CoA dehydrogenase activity
D3U04_RS23880	COG1940	carbohydrate kinase activity
D3U04_RS23880	COG1846	Transcriptional regulator
D3U04_RS23895	COG1960	acyl-CoA dehydrogenase activity
D3U04_RS23965	COG2076	Multidrug Resistance protein
D3U04_RS23970	COG3339	Conserved Protein
D3U04_RS23975	COG1280	lysine exporter protein (LysE YggA)
D3U04_RS24000	COG4555	ABC transporter
D3U04_RS24025	COG0463	Glycosyl transferase, family 2
D3U04_RS24030	COG1960	acyl-CoA dehydrogenase activity
D3U04_RS24035	COG1309	transcriptional regulator
D3U04_RS24065	COG0346	lactoylglutathione lyase activity
D3U04_RS24075	COG0243	molybdopterin cofactor binding
D3U04_RS24090	COG1131	(ABC) transporter
D3U04_RS24095	COG2197	response regulator
D3U04_RS24100	COG4585	Histidine kinase
D3U04_RS24105	COG2132	Multicopper oxidase
D3U04_RS24115	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
D3U04_RS24120	COG4221	oxidoreductase activity
D3U04_RS24140	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
D3U04_RS24160	COG1028	Short-chain dehydrogenase reductase Sdr
D3U04_RS24170	COG2084	Dehydrogenase
D3U04_RS24175	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
D3U04_RS24175	COG0825	malonyl-CoA metabolic process
D3U04_RS24195	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
D3U04_RS24200	COG2867	negative regulation of translational initiation
D3U04_RS24200	COG2226	methyltransferase
D3U04_RS24205	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
D3U04_RS24210	COG2867	negative regulation of translational initiation
D3U04_RS24245	COG0439	Biotin carboxylase
D3U04_RS24250	COG0511	ligase activity, forming carbon-carbon bonds
D3U04_RS24260	COG1271	oxidase subunit
D3U04_RS24265	COG1294	oxidase, subunit
D3U04_RS24270	COG2274	protein secretion by the type I secretion system
D3U04_RS24275	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
D3U04_RS24315	COG3629	intracellular signal transduction
D3U04_RS24315	COG3903	Transcriptional regulator
D3U04_RS24325	COG2124	cytochrome p450
D3U04_RS24360	COG3104	oligopeptide transport
D3U04_RS24370	COG2050	protein possibly involved in aromatic compounds catabolism
D3U04_RS24380	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D3U04_RS24390	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
D3U04_RS24395	COG0657	acetylesterase activity
D3U04_RS24405	COG1309	transcriptional regulator
D3U04_RS24410	COG2234	aminopeptidase activity
D3U04_RS24415	COG0438	transferase activity, transferring glycosyl groups
D3U04_RS24430	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
D3U04_RS24435	COG1414	Transcriptional regulator
D3U04_RS24450	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
D3U04_RS24465	COG3629	intracellular signal transduction
D3U04_RS24465	COG3903	Transcriptional regulator
D3U04_RS24475	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D3U04_RS24485	COG2890	protein-(glutamine-N5) methyltransferase activity
D3U04_RS24500	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
D3U04_RS24505	COG0753	catalase activity
D3U04_RS24515	COG1522	sequence-specific DNA binding
D3U04_RS24520	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
D3U04_RS24580	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
D3U04_RS24630	COG2124	cytochrome p450
D3U04_RS24635	COG4977	sequence-specific DNA binding
D3U04_RS24635	COG1917	Cupin 2, conserved barrel domain protein
D3U04_RS24675	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
D3U04_RS24680	COG0494	nUDIX hydrolase
D3U04_RS24690	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
D3U04_RS24705	COG0457	Tetratricopeptide repeat
D3U04_RS24725	COG1716	ATPase activity
D3U04_RS24750	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
D3U04_RS24750	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
D3U04_RS24785	COG2223	nitrite transmembrane transporter activity
D3U04_RS24800	COG0243	molybdopterin cofactor binding
D3U04_RS24805	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
D3U04_RS24810	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
D3U04_RS24810	COG2146	nitrite reductase [NAD(P)H] activity
D3U04_RS24845	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
D3U04_RS24860	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
D3U04_RS24865	COG4948	Mandelate Racemase Muconate Lactonizing
D3U04_RS24870	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
D3U04_RS24910	COG4941	Belongs to the sigma-70 factor family
D3U04_RS24915	COG3795	YCII-related domain
D3U04_RS24925	COG0673	inositol 2-dehydrogenase activity
D3U04_RS24930	COG2378	regulation of single-species biofilm formation
D3U04_RS24935	COG1169	isochorismate synthase
D3U04_RS24960	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
D3U04_RS24970	COG1649	PFAM Uncharacterised BCR, COG1649
D3U04_RS24995	COG5006	permease, DMT superfamily
D3U04_RS25010	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D3U04_RS25015	COG2313	pseudouridylate synthase activity
D3U04_RS25030	COG0789	Transcriptional regulator
D3U04_RS25035	COG0702	epimerase
D3U04_RS25040	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
D3U04_RS25045	COG2197	response regulator
D3U04_RS25050	COG4585	Histidine kinase
D3U04_RS25065	COG2375	cellular response to nickel ion
D3U04_RS25065	COG1132	(ABC) transporter
D3U04_RS25070	COG1132	(ABC) transporter
D3U04_RS25085	COG0640	Transcriptional regulator
D3U04_RS25115	COG2205	protein histidine kinase activity
D3U04_RS25120	COG0745	RESPONSE REGULATOR receiver
D3U04_RS25160	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
D3U04_RS25210	COG0583	DNA-binding transcription factor activity
D3U04_RS25215	COG0402	S-adenosylhomocysteine deaminase activity
D3U04_RS25250	COG1357	PFAM Pentapeptide repeats (8 copies)
D3U04_RS25260	COG0318	PFAM AMP-dependent synthetase and ligase
D3U04_RS25270	COG4974	Belongs to the 'phage' integrase family
D3U04_RS25280	COG1309	transcriptional regulator
D3U04_RS25295	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
D3U04_RS25355	COG4974	Belongs to the 'phage' integrase family
D3U04_RS25410	COG2304	oxidoreductase activity
D3U04_RS25415	COG2813	Specifically methylates the guanine in position
D3U04_RS25420	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
D3U04_RS25485	COG3483	tryptophan 2,3-dioxygenase activity
D3U04_RS25490	COG0009	L-threonylcarbamoyladenylate synthase
D3U04_RS25505	COG0740	serine-type endopeptidase activity
D3U04_RS25535	COG3030	protein affecting phage T7 exclusion by the F plasmid
D3U04_RS25540	COG1216	Glycosyl transferase, family 2
D3U04_RS25550	COG1607	acyl-coa hydrolase
D3U04_RS25555	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
D3U04_RS25560	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
D3U04_RS25570	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D3U04_RS25590	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
D3U04_RS25600	COG0604	alcohol dehydrogenase
D3U04_RS25605	COG1509	lysine 2,3-aminomutase activity
D3U04_RS25615	COG1960	acyl-CoA dehydrogenase activity
D3U04_RS25625	COG3012	SEC-C Motif Domain Protein
D3U04_RS25640	COG1522	sequence-specific DNA binding
D3U04_RS25645	COG1609	Transcriptional regulator
D3U04_RS25655	COG1970	mechanosensitive ion channel activity
D3U04_RS25700	COG0395	ABC-type sugar transport system, permease component
D3U04_RS25705	COG1175	transmembrane transport
D3U04_RS25710	COG1653	transport
D3U04_RS25725	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
D3U04_RS25745	COG0805	protein transport
D3U04_RS25750	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
D3U04_RS25760	COG2378	regulation of single-species biofilm formation
D3U04_RS25790	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
D3U04_RS25795	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
D3U04_RS25800	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
D3U04_RS25815	COG4122	O-methyltransferase activity
D3U04_RS25820	COG1222	aaa ATPase
D3U04_RS25830	COG0517	IMP dehydrogenase activity
D3U04_RS25830	COG1994	Peptidase M50
D3U04_RS25840	COG4585	Histidine kinase
D3U04_RS25845	COG2197	response regulator
D3U04_RS25850	COG1136	(ABC) transporter
D3U04_RS25855	COG1136	(ABC) transporter
D3U04_RS25855	COG0577	efflux transmembrane transporter activity
D3U04_RS25865	COG4608	Belongs to the ABC transporter superfamily
D3U04_RS25885	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D3U04_RS25900	COG1410	methionine synthase
D3U04_RS25900	COG0646	methionine synthase
D3U04_RS25920	COG0215	cysteine-tRNA ligase activity
D3U04_RS25945	COG0598	Magnesium transport protein CorA
D3U04_RS25950	COG0667	Aldo Keto reductase
D3U04_RS25985	COG3360	Dodecin
D3U04_RS26030	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
D3U04_RS26035	COG2267	carboxylic ester hydrolase activity
D3U04_RS26045	COG1690	Belongs to the RtcB family
D3U04_RS26070	COG2261	transglycosylase associated protein
D3U04_RS26075	COG0709	Synthesizes selenophosphate from selenide and ATP
D3U04_RS26110	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
D3U04_RS26115	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
D3U04_RS26115	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
D3U04_RS26120	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
D3U04_RS26125	COG0297	glycogen (starch) synthase activity
D3U04_RS26130	COG2192	nodulation
D3U04_RS26135	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
D3U04_RS26150	COG0859	PFAM glycosyl transferase family 9
D3U04_RS26185	COG0745	RESPONSE REGULATOR receiver
D3U04_RS26190	COG2205	protein histidine kinase activity
D3U04_RS26205	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
D3U04_RS26215	COG0596	Alpha beta hydrolase
D3U04_RS26220	COG2364	Membrane
D3U04_RS26235	COG2271	Major facilitator Superfamily
D3U04_RS26240	COG1929	Belongs to the glycerate kinase type-1 family
D3U04_RS26250	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
D3U04_RS26275	COG0488	(ABC) transporter
D3U04_RS26310	COG2197	response regulator
D3U04_RS26315	COG4585	Histidine kinase
D3U04_RS26325	COG2151	metal-sulfur cluster biosynthetic enzyme
D3U04_RS26330	COG0822	iron-sulfur transferase activity
D3U04_RS26335	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
D3U04_RS26340	COG0396	ATPase activity
D3U04_RS26370	COG0531	amino acid
D3U04_RS26375	COG1131	(ABC) transporter
D3U04_RS26385	COG5006	permease, DMT superfamily
D3U04_RS26390	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
D3U04_RS26390	COG1796	DNA polymerase
D3U04_RS26405	COG0109	protoheme IX farnesyltransferase activity
D3U04_RS26410	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
D3U04_RS26415	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
D3U04_RS26420	COG0166	Belongs to the GPI family
D3U04_RS26440	COG0363	glucosamine-6-phosphate deaminase activity
D3U04_RS26450	COG2205	protein histidine kinase activity
D3U04_RS26450	COG0784	Response regulator, receiver
D3U04_RS26460	COG2172	sigma factor antagonist activity
D3U04_RS26465	COG1366	Belongs to the anti-sigma-factor antagonist family
D3U04_RS26470	COG1366	Belongs to the anti-sigma-factor antagonist family
D3U04_RS26475	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
D3U04_RS26475	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D3U04_RS26490	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
D3U04_RS26515	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
D3U04_RS26530	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
D3U04_RS26535	COG1481	regulation of sporulation
D3U04_RS26545	COG1660	Displays ATPase and GTPase activities
D3U04_RS26550	COG0322	excinuclease ABC activity
D3U04_RS26570	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
D3U04_RS26615	COG1070	Carbohydrate kinase
D3U04_RS26630	COG1472	Belongs to the glycosyl hydrolase 3 family
D3U04_RS26635	COG1609	Transcriptional regulator
D3U04_RS26650	COG1501	Belongs to the glycosyl hydrolase 31 family
D3U04_RS26655	COG0395	ABC-type sugar transport system, permease component
D3U04_RS26660	COG1175	transmembrane transport
D3U04_RS26740	COG0497	DNA recombination
D3U04_RS26745	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
D3U04_RS26765	COG0584	glycerophosphoryl diester phosphodiesterase
D3U04_RS26770	COG0647	UMP catabolic process
D3U04_RS26815	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
D3U04_RS26820	COG2094	Belongs to the DNA glycosylase MPG family
D3U04_RS26825	COG0165	Argininosuccinate lyase
D3U04_RS26830	COG0137	argininosuccinate synthase activity
D3U04_RS26835	COG1438	arginine binding
D3U04_RS26840	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
D3U04_RS26845	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
D3U04_RS26850	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
D3U04_RS26855	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
D3U04_RS26860	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
D3U04_RS26875	COG0488	(ABC) transporter
D3U04_RS26880	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
D3U04_RS26880	COG0072	phenylalanine-tRNA ligase activity
D3U04_RS26885	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
D3U04_RS26890	COG5002	protein histidine kinase activity
D3U04_RS26900	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
D3U04_RS26905	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
D3U04_RS26910	COG0291	Belongs to the bacterial ribosomal protein bL35 family
D3U04_RS26915	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
D3U04_RS26930	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
D3U04_RS26940	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
D3U04_RS26945	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
D3U04_RS26980	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
D3U04_RS26985	COG0124	histidyl-tRNA synthetase
D3U04_RS26995	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
D3U04_RS27000	COG1196	nuclear chromosome segregation
D3U04_RS27010	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
D3U04_RS27015	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
D3U04_RS27020	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
D3U04_RS27025	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
D3U04_RS27030	COG1862	Preprotein translocase
D3U04_RS27035	COG2255	four-way junction helicase activity
D3U04_RS27040	COG0632	four-way junction helicase activity
D3U04_RS27045	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
D3U04_RS27050	COG0217	transcriptional regulatory protein
D3U04_RS27055	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
D3U04_RS27065	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
D3U04_RS27080	COG0438	transferase activity, transferring glycosyl groups
D3U04_RS27085	COG1560	Kdo2-lipid A biosynthetic process
D3U04_RS27090	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
D3U04_RS27120	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
D3U04_RS27125	COG0477	Major facilitator Superfamily
D3U04_RS27130	COG4585	Histidine kinase
D3U04_RS27135	COG2197	response regulator
D3U04_RS27155	COG1960	acyl-CoA dehydrogenase activity
D3U04_RS27165	COG0318	PFAM AMP-dependent synthetase and ligase
D3U04_RS27170	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
D3U04_RS27190	COG0640	Transcriptional regulator
D3U04_RS27195	COG0318	PFAM AMP-dependent synthetase and ligase
D3U04_RS27255	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
D3U04_RS27370	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D3U04_RS27385	COG1028	Short-chain dehydrogenase reductase Sdr
D3U04_RS27425	COG1366	Belongs to the anti-sigma-factor antagonist family
D3U04_RS27455	COG1028	Short-chain dehydrogenase reductase Sdr
D3U04_RS27500	COG0596	Alpha beta hydrolase
D3U04_RS27505	COG2378	regulation of single-species biofilm formation
D3U04_RS27545	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
D3U04_RS27580	COG1063	alcohol dehydrogenase
D3U04_RS27585	COG0673	inositol 2-dehydrogenase activity
D3U04_RS27590	COG1215	transferase activity, transferring glycosyl groups
D3U04_RS27665	COG2234	aminopeptidase activity
D3U04_RS27665	COG4935	Belongs to the peptidase S8 family
D3U04_RS27775	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
D3U04_RS27790	COG0248	Ppx GppA phosphatase
D3U04_RS27800	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D3U04_RS27805	COG0477	Major facilitator Superfamily
D3U04_RS27830	COG0588	phosphoglycerate mutase activity
D3U04_RS27845	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D3U04_RS27855	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
D3U04_RS27865	COG1028	Short-chain dehydrogenase reductase Sdr
D3U04_RS27865	COG3347	Dehydrogenase
D3U04_RS27890	COG1172	Belongs to the binding-protein-dependent transport system permease family
D3U04_RS27895	COG1129	ABC transporter
D3U04_RS27905	COG0247	lactate metabolic process
D3U04_RS27910	COG1139	Iron-sulfur cluster binding protein
D3U04_RS27915	COG1556	Lactate utilization protein
D3U04_RS27920	COG1070	Carbohydrate kinase
D3U04_RS27960	COG3467	pyridoxamine 5'-phosphate
D3U04_RS27965	COG1643	Atp-dependent helicase
D3U04_RS27990	COG3284	Transcriptional regulator
D3U04_RS28065	COG0662	Cupin 2, conserved barrel domain protein
D3U04_RS28100	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
D3U04_RS28115	COG1960	acyl-CoA dehydrogenase activity
D3U04_RS28125	COG0477	Major facilitator Superfamily
D3U04_RS28130	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
D3U04_RS28130	COG0235	Class ii aldolase
D3U04_RS28145	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
D3U04_RS28160	COG2197	response regulator
D3U04_RS28165	COG4585	Histidine kinase
D3U04_RS28170	COG0586	Pfam SNARE associated Golgi protein
D3U04_RS28180	COG2205	protein histidine kinase activity
D3U04_RS28185	COG0745	RESPONSE REGULATOR receiver
D3U04_RS28190	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
D3U04_RS28205	COG0714	Associated with various cellular activities
D3U04_RS28230	COG0318	PFAM AMP-dependent synthetase and ligase
D3U04_RS28250	COG1764	response to oxidative stress
D3U04_RS28270	COG3304	Inner membrane component domain
D3U04_RS28290	COG0328	RNA-DNA hybrid ribonuclease activity
D3U04_RS28325	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
D3U04_RS28375	COG4941	Belongs to the sigma-70 factor family
D3U04_RS28400	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D3U04_RS28455	COG0419	ATPase involved in DNA repair
D3U04_RS28460	COG0420	3'-5' exonuclease activity
D3U04_RS28490	COG1733	regulation of RNA biosynthetic process
D3U04_RS28530	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
D3U04_RS28575	COG2807	transmembrane transport
D3U04_RS28580	COG0668	transmembrane transport
D3U04_RS28605	COG0438	transferase activity, transferring glycosyl groups
D3U04_RS28610	COG1672	PFAM Archaeal ATPase
D3U04_RS28610	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
D3U04_RS28620	COG1136	(ABC) transporter
D3U04_RS28620	COG0577	efflux transmembrane transporter activity
D3U04_RS28625	COG1136	(ABC) transporter
D3U04_RS28640	COG0745	RESPONSE REGULATOR receiver
D3U04_RS28645	COG2205	protein histidine kinase activity
D3U04_RS28655	COG1960	acyl-CoA dehydrogenase activity
D3U04_RS28670	COG0235	Class ii aldolase
D3U04_RS28685	COG0443	Heat shock 70 kDa protein
D3U04_RS28715	COG1309	transcriptional regulator
D3U04_RS28730	COG1522	sequence-specific DNA binding
D3U04_RS28760	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
D3U04_RS28765	COG0183	Belongs to the thiolase family
D3U04_RS28770	COG1804	L-carnitine dehydratase bile acid-inducible protein F
D3U04_RS28795	COG0714	Associated with various cellular activities
D3U04_RS28800	COG2425	protein containing a von Willebrand factor type A (vWA) domain
D3U04_RS28805	COG3552	Protein containing von Willebrand factor type A (VWA) domain
D3U04_RS28810	COG0596	Alpha beta hydrolase
D3U04_RS28845	COG1597	lipid kinase activity
D3U04_RS28850	COG2072	flavoprotein involved in K transport
D3U04_RS28875	COG0419	ATPase involved in DNA repair
D3U04_RS28885	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
D3U04_RS28885	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
D3U04_RS28900	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
D3U04_RS28950	COG1129	ABC transporter
D3U04_RS28965	COG2084	Dehydrogenase
D3U04_RS28980	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
D3U04_RS29000	COG0438	transferase activity, transferring glycosyl groups
D3U04_RS29050	COG0386	Belongs to the glutathione peroxidase family
D3U04_RS29060	COG1316	TRANSCRIPTIONal
D3U04_RS29065	COG1132	(ABC) transporter
D3U04_RS29110	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
D3U04_RS29125	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D3U04_RS29140	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
D3U04_RS29140	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
D3U04_RS29195	COG1162	GTPase activity
D3U04_RS29210	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
D3U04_RS29250	COG0175	sulfate reduction
D3U04_RS29270	COG1960	acyl-CoA dehydrogenase activity
D3U04_RS29320	COG1595	DNA-templated transcription, initiation
D3U04_RS29335	COG1793	dna ligase
D3U04_RS29340	COG3540	Alkaline phosphatase
D3U04_RS29355	COG2936	dipeptidyl-peptidase activity
D3U04_RS29365	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
D3U04_RS29375	COG3253	May function as heme-dependent peroxidase
D3U04_RS29380	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
D3U04_RS29390	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
D3U04_RS29415	COG0183	Belongs to the thiolase family
D3U04_RS29420	COG1250	3-hydroxyacyl-CoA dehydrogenase
D3U04_RS29420	COG1024	Enoyl-CoA hydratase
D3U04_RS29425	COG0531	amino acid
D3U04_RS29430	COG0493	'glutamate synthase
D3U04_RS29435	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
D3U04_RS29440	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
D3U04_RS29475	COG3663	DNA glycosylase
D3U04_RS29495	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
D3U04_RS29515	COG2226	methyltransferase
D3U04_RS29520	COG0800	Aldolase
D3U04_RS29525	COG0837	glucose binding
D3U04_RS29530	COG0129	dihydroxy-acid dehydratase activity
D3U04_RS29550	COG1653	transport
D3U04_RS29565	COG0366	Alpha amylase catalytic
D3U04_RS29595	COG0395	ABC-type sugar transport system, permease component
D3U04_RS29640	COG1280	lysine exporter protein (LysE YggA)
D3U04_RS29645	COG0318	PFAM AMP-dependent synthetase and ligase
D3U04_RS29665	COG1280	lysine exporter protein (LysE YggA)
D3U04_RS29685	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
D3U04_RS29705	COG0477	Major facilitator Superfamily
D3U04_RS29735	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
D3U04_RS29740	COG0531	amino acid
D3U04_RS29745	COG0569	domain protein
D3U04_RS29790	COG0756	dUTP diphosphatase activity
D3U04_RS29815	COG0525	valine-tRNA ligase activity
D3U04_RS29850	COG2205	protein histidine kinase activity
D3U04_RS29855	COG0745	RESPONSE REGULATOR receiver
D3U04_RS29865	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
D3U04_RS29890	COG3402	PFAM membrane-flanked domain
D3U04_RS29905	COG1252	NADH dehydrogenase
D3U04_RS29910	COG1881	PFAM PEBP family protein
D3U04_RS29925	COG0288	reversible hydration of carbon dioxide
D3U04_RS29945	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
D3U04_RS29960	COG1280	lysine exporter protein (LysE YggA)
D3U04_RS29965	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
D3U04_RS29990	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
D3U04_RS30025	COG0596	Alpha beta hydrolase
D3U04_RS30025	COG2945	thiolester hydrolase activity
D3U04_RS30050	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
D3U04_RS30060	COG1764	response to oxidative stress
D3U04_RS30070	COG1619	proteins homologs of microcin C7 resistance protein MccF
D3U04_RS30125	COG2814	Major facilitator Superfamily
D3U04_RS30175	COG4566	intracellular signal transduction
D3U04_RS30190	COG0464	growth
D3U04_RS30195	COG4451	ribulose bisphosphate carboxylase, small
D3U04_RS30200	COG1850	ribulose-bisphosphate carboxylase activity
D3U04_RS30210	COG3268	Saccharopine dehydrogenase
D3U04_RS30225	COG2197	response regulator
D3U04_RS30230	COG0572	uridine kinase
D3U04_RS30295	COG2267	carboxylic ester hydrolase activity
D3U04_RS30305	COG0154	amidase activity
D3U04_RS30310	COG1796	DNA polymerase
D3U04_RS30310	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
D3U04_RS30315	COG4585	Histidine kinase
D3U04_RS30345	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
D3U04_RS30350	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
D3U04_RS30375	COG0815	Transfers the fatty acyl group on membrane lipoproteins
D3U04_RS30535	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
D3U04_RS30540	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
D3U04_RS30550	COG0596	Alpha beta hydrolase
D3U04_RS30580	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D3U04_RS30610	COG0019	diaminopimelate decarboxylase activity
D3U04_RS30620	COG1309	transcriptional regulator
D3U04_RS30625	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
D3U04_RS30630	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
D3U04_RS30645	COG0583	DNA-binding transcription factor activity
D3U04_RS30650	COG0596	Alpha beta hydrolase
D3U04_RS30655	COG3903	Transcriptional regulator
D3U04_RS30655	COG3629	intracellular signal transduction
D3U04_RS30660	COG1902	pentaerythritol trinitrate reductase activity
D3U04_RS30695	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
D3U04_RS30695	COG0116	Belongs to the methyltransferase superfamily
D3U04_RS30750	COG0531	amino acid
D3U04_RS30760	COG1309	transcriptional regulator
D3U04_RS30765	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
D3U04_RS30800	COG1132	(ABC) transporter
D3U04_RS30805	COG2755	lipolytic protein G-D-S-L family
D3U04_RS30810	COG0252	asparaginase activity
D3U04_RS30820	COG3835	regulator
D3U04_RS30845	COG4941	Belongs to the sigma-70 factor family
D3U04_RS30865	COG1960	acyl-CoA dehydrogenase activity
D3U04_RS30900	COG4257	antibiotic catabolic process
D3U04_RS30905	COG0488	(ABC) transporter
D3U04_RS30915	COG0789	Transcriptional regulator
D3U04_RS30930	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
D3U04_RS30965	COG1408	metallophosphoesterase
D3U04_RS30975	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
D3U04_RS31030	COG0305	Participates in initiation and elongation during chromosome replication
D3U04_RS31110	COG2807	transmembrane transport
D3U04_RS31115	COG2186	Transcriptional regulator
D3U04_RS31135	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
D3U04_RS31170	COG0592	DNA-directed DNA polymerase activity
D3U04_RS31180	COG0305	Participates in initiation and elongation during chromosome replication
D3U04_RS31185	COG0534	Mate efflux family protein
D3U04_RS31205	COG0359	binds to the 23S rRNA
D3U04_RS31210	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
D3U04_RS31220	COG0360	Binds together with S18 to 16S ribosomal RNA
D3U04_RS31245	COG4977	sequence-specific DNA binding
D3U04_RS31260	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
D3U04_RS31295	COG4941	Belongs to the sigma-70 factor family
D3U04_RS31330	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
D3U04_RS31335	COG0492	ferredoxin-NADP+ reductase activity
D3U04_RS31350	COG1595	DNA-templated transcription, initiation
D3U04_RS31355	COG2815	serine threonine protein kinase
D3U04_RS31355	COG0515	serine threonine protein kinase
D3U04_RS31375	COG0617	tRNA 3'-terminal CCA addition
D3U04_RS31380	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
D3U04_RS31395	COG0747	negative chemotaxis
D3U04_RS31410	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D3U04_RS31420	COG1181	Belongs to the D-alanine--D-alanine ligase family
D3U04_RS31430	COG1192	Involved in chromosome partitioning
D3U04_RS31435	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
D3U04_RS31440	COG0357	Ribosomal RNA small subunit methyltransferase G
D3U04_RS31455	COG0706	membrane insertase activity
D3U04_RS31460	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
D3U04_RS31470	COG0230	Belongs to the bacterial ribosomal protein bL34 family
D3U04_RS31815	COG4981	capsule polysaccharide biosynthetic process
D3U04_RS32080	COG0582	viral genome integration into host DNA
D3U04_RS32110	COG1309	transcriptional regulator
D3U04_RS32255	COG0444	Belongs to the ABC transporter superfamily
D3U04_RS32330	COG1358	cellular component organization or biogenesis
D3U04_RS32375	COG0791	NLP P60 protein
D3U04_RS32480	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
D3U04_RS32510	COG2205	protein histidine kinase activity
D3U04_RS32570	COG3321	synthase
D3U04_RS32570	COG0604	alcohol dehydrogenase