locus-tag	class	description
TCUR_RS00010	COG0592	DNA-directed DNA polymerase activity
TCUR_RS00015	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
TCUR_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
TCUR_RS00025	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
TCUR_RS00035	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
TCUR_RS00120	COG2252	PERMEase
TCUR_RS00125	COG1253	flavin adenine dinucleotide binding
TCUR_RS00155	COG3973	AAA domain
TCUR_RS00160	COG0667	Aldo Keto reductase
TCUR_RS00225	COG2188	Transcriptional regulator
TCUR_RS00255	COG1262	PFAM Formylglycine-generating sulfatase enzyme
TCUR_RS00265	COG3119	arylsulfatase activity
TCUR_RS00285	COG0705	Rhomboid family
TCUR_RS00310	COG0515	serine threonine protein kinase
TCUR_RS00320	COG0768	penicillin binding
TCUR_RS00335	COG1716	ATPase activity
TCUR_RS00375	COG4558	Periplasmic binding protein
TCUR_RS00380	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TCUR_RS00385	COG1120	ATPase activity
TCUR_RS00395	COG5398	heme oxygenase
TCUR_RS00420	COG0475	glutathione-regulated potassium exporter activity
TCUR_RS00445	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
TCUR_RS00455	COG2608	mercury ion transmembrane transporter activity
TCUR_RS00465	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
TCUR_RS00480	COG2235	arginine
TCUR_RS00490	COG1028	Short-chain dehydrogenase reductase Sdr
TCUR_RS00525	COG0028	Belongs to the TPP enzyme family
TCUR_RS00540	COG2197	response regulator
TCUR_RS00545	COG4585	Histidine kinase
TCUR_RS00555	COG2409	Drug exporters of the RND superfamily
TCUR_RS00585	COG5650	phosphatidylinositol metabolic process
TCUR_RS00595	COG0077	Prephenate dehydratase
TCUR_RS00605	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
TCUR_RS00620	COG0561	phosphatase activity
TCUR_RS00640	COG0515	serine threonine protein kinase
TCUR_RS00640	COG2815	serine threonine protein kinase
TCUR_RS00645	COG0840	transmembrane signaling receptor activity
TCUR_RS00650	COG1280	lysine exporter protein (LysE YggA)
TCUR_RS00655	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
TCUR_RS00705	COG0655	NAD(P)H dehydrogenase (quinone) activity
TCUR_RS00725	COG1595	DNA-templated transcription, initiation
TCUR_RS00745	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
TCUR_RS00765	COG2197	response regulator
TCUR_RS00790	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
TCUR_RS00795	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
TCUR_RS00800	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
TCUR_RS00850	COG0419	ATPase involved in DNA repair
TCUR_RS00880	COG0584	glycerophosphoryl diester phosphodiesterase
TCUR_RS00925	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
TCUR_RS00945	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
TCUR_RS00960	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
TCUR_RS00965	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
TCUR_RS00975	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
TCUR_RS00980	COG0151	Belongs to the GarS family
TCUR_RS00995	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
TCUR_RS01000	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
TCUR_RS01010	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
TCUR_RS01030	COG0191	fructose-bisphosphate aldolase activity
TCUR_RS01045	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
TCUR_RS01080	COG0404	The glycine cleavage system catalyzes the degradation of glycine
TCUR_RS01085	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
TCUR_RS01090	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
TCUR_RS01095	COG1028	Short-chain dehydrogenase reductase Sdr
TCUR_RS01100	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
TCUR_RS01115	COG2814	Major facilitator Superfamily
TCUR_RS01160	COG0542	response to heat
TCUR_RS01165	COG0789	Transcriptional regulator
TCUR_RS01170	COG0484	heat shock protein binding
TCUR_RS01175	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
TCUR_RS01180	COG0443	Heat shock 70 kDa protein
TCUR_RS01200	COG2181	nitrate reductase activity
TCUR_RS01200	COG0247	lactate metabolic process
TCUR_RS01205	COG0717	Belongs to the dCTP deaminase family
TCUR_RS01265	COG2272	Belongs to the type-B carboxylesterase lipase family
TCUR_RS01275	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
TCUR_RS01280	COG0494	nUDIX hydrolase
TCUR_RS01280	COG0406	alpha-ribazole phosphatase activity
TCUR_RS01285	COG3025	triphosphatase activity
TCUR_RS01285	COG5607	PFAM CHAD domain containing protein
TCUR_RS01325	COG4221	oxidoreductase activity
TCUR_RS01340	COG1960	acyl-CoA dehydrogenase activity
TCUR_RS01375	COG0477	Major facilitator Superfamily
TCUR_RS01385	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
TCUR_RS01395	COG4941	Belongs to the sigma-70 factor family
TCUR_RS01425	COG0167	dihydroorotate dehydrogenase activity
TCUR_RS01430	COG2890	protein-(glutamine-N5) methyltransferase activity
TCUR_RS01435	COG0860	N-Acetylmuramoyl-L-alanine amidase
TCUR_RS01475	COG2949	membrane
TCUR_RS01480	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
TCUR_RS01535	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
TCUR_RS01540	COG0047	phosphoribosylformylglycinamidine synthase activity
TCUR_RS01550	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
TCUR_RS01560	COG1028	Short-chain dehydrogenase reductase Sdr
TCUR_RS01590	COG0702	epimerase
TCUR_RS01605	COG1012	belongs to the aldehyde dehydrogenase family
TCUR_RS01615	COG0022	dehydrogenase e1 component
TCUR_RS01620	COG0508	dehydrogenase complex catalyzes the overall conversion of
TCUR_RS01635	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
TCUR_RS01640	COG1966	Carbon starvation protein
TCUR_RS01675	COG1120	ATPase activity
TCUR_RS01680	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TCUR_RS01695	COG1309	transcriptional regulator
TCUR_RS01700	COG0577	efflux transmembrane transporter activity
TCUR_RS01700	COG1136	(ABC) transporter
TCUR_RS01715	COG1271	oxidase subunit
TCUR_RS01720	COG1294	oxidase, subunit
TCUR_RS01725	COG4988	ABC transporter
TCUR_RS01735	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
TCUR_RS01745	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TCUR_RS01750	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TCUR_RS01755	COG1120	ATPase activity
TCUR_RS01785	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
TCUR_RS01790	COG1021	2,3-dihydroxybenzoate-AMP ligase
TCUR_RS01810	COG1169	isochorismate synthase
TCUR_RS01815	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
TCUR_RS01840	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
TCUR_RS01840	COG0515	serine threonine protein kinase
TCUR_RS01860	COG0515	serine threonine protein kinase
TCUR_RS01935	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
TCUR_RS01950	COG0515	serine threonine protein kinase
TCUR_RS01965	COG1653	transport
TCUR_RS01980	COG0543	2 iron, 2 sulfur cluster binding
TCUR_RS01980	COG0633	Ferredoxin
TCUR_RS01985	COG1151	hydroxylamine reductase activity
TCUR_RS02025	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
TCUR_RS02125	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
TCUR_RS02130	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
TCUR_RS02140	COG1804	L-carnitine dehydratase bile acid-inducible protein F
TCUR_RS02155	COG0420	3'-5' exonuclease activity
TCUR_RS02185	COG1177	transmembrane transport
TCUR_RS02190	COG3842	ATPase activity
TCUR_RS02210	COG1960	acyl-CoA dehydrogenase activity
TCUR_RS02220	COG1028	Short-chain dehydrogenase reductase Sdr
TCUR_RS02235	COG3903	Transcriptional regulator
TCUR_RS02235	COG3629	intracellular signal transduction
TCUR_RS02260	COG2205	protein histidine kinase activity
TCUR_RS02270	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
TCUR_RS02275	COG1116	anion transmembrane transporter activity
TCUR_RS02285	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
TCUR_RS02300	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
TCUR_RS02420	COG3189	MarR family transcriptional regulator
TCUR_RS02430	COG0326	Molecular chaperone. Has ATPase activity
TCUR_RS02440	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
TCUR_RS02495	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
TCUR_RS02510	COG1309	transcriptional regulator
TCUR_RS02550	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
TCUR_RS02555	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
TCUR_RS02560	COG1278	Cold shock
TCUR_RS02615	COG1414	Transcriptional regulator
TCUR_RS02620	COG1414	Transcriptional regulator
TCUR_RS02625	COG3971	2-oxopent-4-enoate hydratase activity
TCUR_RS02645	COG1942	4-Oxalocrotonate Tautomerase
TCUR_RS02660	COG1960	acyl-CoA dehydrogenase activity
TCUR_RS02695	COG2365	Tyrosine phosphatase family
TCUR_RS02700	COG0215	cysteine-tRNA ligase activity
TCUR_RS02710	COG0384	phenazine biosynthesis protein PhzF
TCUR_RS02720	COG0318	PFAM AMP-dependent synthetase and ligase
TCUR_RS02725	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
TCUR_RS02750	COG1773	rubredoxin
TCUR_RS02755	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
TCUR_RS02780	COG2072	flavoprotein involved in K transport
TCUR_RS02790	COG0539	negative regulation of cytoplasmic translation
TCUR_RS02830	COG1028	Short-chain dehydrogenase reductase Sdr
TCUR_RS02840	COG1024	Enoyl-CoA hydratase
TCUR_RS02845	COG0745	RESPONSE REGULATOR receiver
TCUR_RS02850	COG2205	protein histidine kinase activity
TCUR_RS02860	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TCUR_RS02870	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
TCUR_RS02875	COG0242	peptide deformylase activity
TCUR_RS02905	COG0306	phosphate transporter
TCUR_RS02910	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
TCUR_RS02915	COG0581	inorganic phosphate transmembrane transporter activity
TCUR_RS02930	COG0456	acetyltransferase
TCUR_RS02935	COG0745	RESPONSE REGULATOR receiver
TCUR_RS02985	COG1404	Belongs to the peptidase S8 family
TCUR_RS02995	COG1674	ftsk spoiiie
TCUR_RS03010	COG4842	Belongs to the WXG100 family
TCUR_RS03015	COG4842	Belongs to the WXG100 family
TCUR_RS03075	COG1316	TRANSCRIPTIONal
TCUR_RS03090	COG3119	arylsulfatase activity
TCUR_RS03105	COG1216	Glycosyl transferase, family 2
TCUR_RS03110	COG0438	transferase activity, transferring glycosyl groups
TCUR_RS03135	COG1216	Glycosyl transferase, family 2
TCUR_RS03155	COG1215	transferase activity, transferring glycosyl groups
TCUR_RS03165	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
TCUR_RS03170	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
TCUR_RS03170	COG2755	lipolytic protein G-D-S-L family
TCUR_RS03200	COG3442	glutamine amidotransferase
TCUR_RS03215	COG4044	May play a role in the intracellular transport of hydrophobic ligands
TCUR_RS03225	COG0354	folic acid binding
TCUR_RS03235	COG1490	D-aminoacyl-tRNA deacylase activity
TCUR_RS03240	COG3246	L-lysine catabolic process to acetate
TCUR_RS03260	COG2321	neutral zinc metallopeptidase
TCUR_RS03285	COG1309	transcriptional regulator
TCUR_RS03330	COG1396	sequence-specific DNA binding
TCUR_RS03350	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
TCUR_RS03370	COG3384	dioxygenase
TCUR_RS03375	COG0702	epimerase
TCUR_RS03380	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
TCUR_RS03410	COG0438	transferase activity, transferring glycosyl groups
TCUR_RS03420	COG0588	phosphoglycerate mutase activity
TCUR_RS03430	COG5002	protein histidine kinase activity
TCUR_RS03455	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
TCUR_RS03460	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
TCUR_RS03465	COG0179	Fumarylacetoacetate (FAA) hydrolase
TCUR_RS03490	COG0215	cysteine-tRNA ligase activity
TCUR_RS03545	COG0318	PFAM AMP-dependent synthetase and ligase
TCUR_RS03550	COG0179	Fumarylacetoacetate (FAA) hydrolase
TCUR_RS03555	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
TCUR_RS03575	COG1454	alcohol dehydrogenase
TCUR_RS03585	COG0514	ATP-dependent DNA helicase (RecQ)
TCUR_RS03590	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
TCUR_RS03640	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
TCUR_RS03640	COG1672	PFAM Archaeal ATPase
TCUR_RS03645	COG0667	Aldo Keto reductase
TCUR_RS03660	COG0431	NADPH-dependent FMN reductase
TCUR_RS03665	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
TCUR_RS03675	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
TCUR_RS03685	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TCUR_RS03700	COG0559	Belongs to the binding-protein-dependent transport system permease family
TCUR_RS03720	COG2508	Transcriptional regulator
TCUR_RS03755	COG1053	succinate dehydrogenase
TCUR_RS03765	COG0318	PFAM AMP-dependent synthetase and ligase
TCUR_RS03780	COG1024	Enoyl-CoA hydratase
TCUR_RS03785	COG1960	acyl-CoA dehydrogenase activity
TCUR_RS03790	COG0318	PFAM AMP-dependent synthetase and ligase
TCUR_RS03795	COG1028	Short-chain dehydrogenase reductase Sdr
TCUR_RS03800	COG0640	Transcriptional regulator
TCUR_RS03820	COG0443	Heat shock 70 kDa protein
TCUR_RS03900	COG0515	serine threonine protein kinase
TCUR_RS03905	COG1595	DNA-templated transcription, initiation
TCUR_RS03910	COG0457	Tetratricopeptide repeat
TCUR_RS03935	COG0459	protein refolding
TCUR_RS03975	COG1061	Type III restriction enzyme res subunit
TCUR_RS03985	COG0318	PFAM AMP-dependent synthetase and ligase
TCUR_RS04005	COG1309	transcriptional regulator
TCUR_RS04020	COG1278	Cold shock
TCUR_RS04060	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
TCUR_RS04095	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
TCUR_RS04110	COG0259	pyridoxamine-phosphate oxidase activity
TCUR_RS04125	COG2208	phosphoserine phosphatase activity
TCUR_RS04125	COG2172	sigma factor antagonist activity
TCUR_RS04125	COG1366	Belongs to the anti-sigma-factor antagonist family
TCUR_RS04140	COG0183	Belongs to the thiolase family
TCUR_RS04165	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
TCUR_RS04170	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
TCUR_RS04170	COG1672	PFAM Archaeal ATPase
TCUR_RS04185	COG1012	belongs to the aldehyde dehydrogenase family
TCUR_RS04190	COG1012	belongs to the aldehyde dehydrogenase family
TCUR_RS04200	COG0416	fatty acid biosynthetic process
TCUR_RS04220	COG1881	PFAM PEBP family protein
TCUR_RS04245	COG0442	prolyl-tRNA aminoacylation
TCUR_RS04265	COG1595	DNA-templated transcription, initiation
TCUR_RS04285	COG0612	Peptidase, M16
TCUR_RS04290	COG1366	Belongs to the anti-sigma-factor antagonist family
TCUR_RS04320	COG1733	regulation of RNA biosynthetic process
TCUR_RS04325	COG2910	NAD(P)H-binding
TCUR_RS04330	COG2197	response regulator
TCUR_RS04335	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TCUR_RS04340	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
TCUR_RS04350	COG0135	phosphoribosylanthranilate isomerase activity
TCUR_RS04355	COG1280	lysine exporter protein (LysE YggA)
TCUR_RS04380	COG0483	inositol monophosphate 1-phosphatase activity
TCUR_RS04430	COG1970	mechanosensitive ion channel activity
TCUR_RS04445	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
TCUR_RS04450	COG2409	Drug exporters of the RND superfamily
TCUR_RS04470	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
TCUR_RS04475	COG1210	Utp--glucose-1-phosphate uridylyltransferase
TCUR_RS04485	COG0315	cyclic pyranopterin monophosphate synthase activity
TCUR_RS04490	COG0521	Mo-molybdopterin cofactor biosynthetic process
TCUR_RS04540	COG2154	pterin-4-alpha-carbinolamine dehydratase
TCUR_RS04545	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
TCUR_RS04595	COG1203	CRISPR-associated helicase, Cas3
TCUR_RS04605	COG1518	maintenance of DNA repeat elements
TCUR_RS04610	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
TCUR_RS04635	COG1857	crispr-associated protein
TCUR_RS04650	COG1518	maintenance of DNA repeat elements
TCUR_RS04660	COG0546	phosphoglycolate phosphatase activity
TCUR_RS04665	COG0412	Dienelactone hydrolase
TCUR_RS04685	COG1804	L-carnitine dehydratase bile acid-inducible protein F
TCUR_RS04690	COG1309	transcriptional regulator
TCUR_RS04700	COG1960	acyl-CoA dehydrogenase activity
TCUR_RS04715	COG0318	PFAM AMP-dependent synthetase and ligase
TCUR_RS04725	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
TCUR_RS04745	COG0406	alpha-ribazole phosphatase activity
TCUR_RS04760	COG0501	Belongs to the peptidase M48B family
TCUR_RS04770	COG0598	Magnesium transport protein CorA
TCUR_RS04800	COG0463	Glycosyl transferase, family 2
TCUR_RS04815	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TCUR_RS04820	COG0084	hydrolase, TatD family'
TCUR_RS04830	COG0741	lytic transglycosylase activity
TCUR_RS04840	COG1595	DNA-templated transcription, initiation
TCUR_RS04845	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
TCUR_RS04855	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
TCUR_RS04870	COG0488	(ABC) transporter
TCUR_RS04880	COG4106	trans-aconitate 2-methyltransferase activity
TCUR_RS04890	COG1309	transcriptional regulator
TCUR_RS04910	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
TCUR_RS04915	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
TCUR_RS04920	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
TCUR_RS04925	COG0193	aminoacyl-tRNA hydrolase activity
TCUR_RS04930	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
TCUR_RS04935	COG1218	3'(2'),5'-bisphosphate nucleotidase
TCUR_RS05025	COG0730	response to heat
TCUR_RS05030	COG0529	Catalyzes the synthesis of activated sulfate
TCUR_RS05055	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
TCUR_RS05070	COG1703	isobutyryl-CoA mutase activity
TCUR_RS05070	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
TCUR_RS05070	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
TCUR_RS05090	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
TCUR_RS05095	COG1116	anion transmembrane transporter activity
TCUR_RS05105	COG0148	phosphopyruvate hydratase activity
TCUR_RS05125	COG1573	uracil-dna glycosylase
TCUR_RS05130	COG1252	NADH dehydrogenase
TCUR_RS05135	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
TCUR_RS05155	COG0183	Belongs to the thiolase family
TCUR_RS05165	COG2755	lipolytic protein G-D-S-L family
TCUR_RS05175	COG2409	Drug exporters of the RND superfamily
TCUR_RS05200	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
TCUR_RS05215	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
TCUR_RS05240	COG3185	4-Hydroxyphenylpyruvate dioxygenase
TCUR_RS05250	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
TCUR_RS05260	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
TCUR_RS05280	COG1234	tRNA 3'-trailer cleavage
TCUR_RS05285	COG1331	Highly conserved protein containing a thioredoxin domain
TCUR_RS05305	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
TCUR_RS05310	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
TCUR_RS05320	COG0114	fumarate hydratase activity
TCUR_RS05335	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
TCUR_RS05335	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
TCUR_RS05375	COG1722	exodeoxyribonuclease VII activity
TCUR_RS05380	COG1570	exodeoxyribonuclease VII activity
TCUR_RS05390	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
TCUR_RS05400	COG1322	Protein conserved in bacteria
TCUR_RS05410	COG0012	GTP binding
TCUR_RS05465	COG1217	gtp-binding protein TYPA
TCUR_RS05485	COG0542	response to heat
TCUR_RS05510	COG1053	succinate dehydrogenase
TCUR_RS05520	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
TCUR_RS05540	COG1053	succinate dehydrogenase
TCUR_RS05550	COG0784	Response regulator, receiver
TCUR_RS05555	COG4251	negative regulation of phosphorylation
TCUR_RS05565	COG1132	(ABC) transporter
TCUR_RS05570	COG1132	(ABC) transporter
TCUR_RS05585	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
TCUR_RS05605	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
TCUR_RS05610	COG1522	sequence-specific DNA binding
TCUR_RS05615	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
TCUR_RS05645	COG1073	alpha beta
TCUR_RS05645	COG2226	methyltransferase
TCUR_RS05655	COG1024	Enoyl-CoA hydratase
TCUR_RS05660	COG0726	polysaccharide deacetylase
TCUR_RS05705	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
TCUR_RS05715	COG1960	acyl-CoA dehydrogenase activity
TCUR_RS05755	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
TCUR_RS05775	COG2171	N-acyltransferase activity
TCUR_RS05780	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
TCUR_RS05785	COG1611	Belongs to the LOG family
TCUR_RS05790	COG1611	Belongs to the LOG family
TCUR_RS05795	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
TCUR_RS05810	COG2818	Glycosylase
TCUR_RS05815	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
TCUR_RS05830	COG1595	DNA-templated transcription, initiation
TCUR_RS05845	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TCUR_RS05850	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
TCUR_RS05865	COG2239	Acts as a magnesium transporter
TCUR_RS05875	COG2301	Belongs to the HpcH HpaI aldolase family
TCUR_RS05910	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
TCUR_RS05915	COG0513	Belongs to the DEAD box helicase family
TCUR_RS05925	COG0515	serine threonine protein kinase
TCUR_RS05945	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
TCUR_RS05950	COG3285	dna ligase
TCUR_RS05950	COG1793	dna ligase
TCUR_RS05960	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
TCUR_RS05970	COG0438	transferase activity, transferring glycosyl groups
TCUR_RS05975	COG0463	Glycosyl transferase, family 2
TCUR_RS05975	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
TCUR_RS05985	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
TCUR_RS06005	COG2259	Doxx family
TCUR_RS06010	COG0613	PHP domain protein
TCUR_RS06020	COG0789	Transcriptional regulator
TCUR_RS06025	COG1028	Short-chain dehydrogenase reductase Sdr
TCUR_RS06035	COG1295	ribonuclease BN
TCUR_RS06045	COG1960	acyl-CoA dehydrogenase activity
TCUR_RS06050	COG1024	Enoyl-CoA hydratase
TCUR_RS06065	COG0776	regulation of translation
TCUR_RS06070	COG0737	Belongs to the 5'-nucleotidase family
TCUR_RS06085	COG0318	PFAM AMP-dependent synthetase and ligase
TCUR_RS06100	COG0427	acetyl-CoA hydrolase
TCUR_RS06165	COG2197	response regulator
TCUR_RS06175	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
TCUR_RS06190	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
TCUR_RS06220	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
TCUR_RS06265	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
TCUR_RS06270	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
TCUR_RS06285	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
TCUR_RS06345	COG1492	cobalamin metabolic process
TCUR_RS06405	COG2197	response regulator
TCUR_RS06410	COG4585	Histidine kinase
TCUR_RS06420	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
TCUR_RS06460	COG1797	cobyrinic acid a,c-diamide synthase activity
TCUR_RS06480	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
TCUR_RS06515	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
TCUR_RS06520	COG1648	precorrin-2 dehydrogenase activity
TCUR_RS06520	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
TCUR_RS06535	COG0629	single-stranded DNA binding
TCUR_RS06555	COG2271	Major facilitator Superfamily
TCUR_RS06565	COG0668	transmembrane transport
TCUR_RS06585	COG2226	methyltransferase
TCUR_RS06590	COG1505	serine-type exopeptidase activity
TCUR_RS06615	COG0129	dihydroxy-acid dehydratase activity
TCUR_RS06625	COG0154	amidase activity
TCUR_RS06645	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
TCUR_RS06665	COG1122	ATPase activity
TCUR_RS06685	COG3850	Histidine kinase
TCUR_RS06685	COG0642	Histidine kinase
TCUR_RS06690	COG1012	belongs to the aldehyde dehydrogenase family
TCUR_RS06725	COG2814	Major facilitator Superfamily
TCUR_RS06760	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
TCUR_RS06765	COG1116	anion transmembrane transporter activity
TCUR_RS06780	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
TCUR_RS06805	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
TCUR_RS06815	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
TCUR_RS06825	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
TCUR_RS06870	COG0443	Heat shock 70 kDa protein
TCUR_RS06880	COG1100	Small GTP-binding protein
TCUR_RS06920	COG0210	DNA helicase
TCUR_RS06930	COG0515	serine threonine protein kinase
TCUR_RS06930	COG2815	serine threonine protein kinase
TCUR_RS06995	COG3209	COG3209 Rhs family protein
TCUR_RS07045	COG2124	cytochrome p450
TCUR_RS07135	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
TCUR_RS07140	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
TCUR_RS07145	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
TCUR_RS07155	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
TCUR_RS07170	COG2205	protein histidine kinase activity
TCUR_RS07175	COG0745	RESPONSE REGULATOR receiver
TCUR_RS07235	COG0183	Belongs to the thiolase family
TCUR_RS07250	COG1960	acyl-CoA dehydrogenase activity
TCUR_RS07255	COG1960	acyl-CoA dehydrogenase activity
TCUR_RS07300	COG2197	response regulator
TCUR_RS07315	COG0318	PFAM AMP-dependent synthetase and ligase
TCUR_RS07345	COG1201	RNA secondary structure unwinding
TCUR_RS07365	COG4245	von Willebrand factor, type A
TCUR_RS07395	COG3311	Transcriptional regulator
TCUR_RS07400	COG1569	PIN domain
TCUR_RS07500	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
TCUR_RS07505	COG0778	Nitroreductase
TCUR_RS07525	COG0544	peptidyl-prolyl cis-trans isomerase activity
TCUR_RS07530	COG0740	serine-type endopeptidase activity
TCUR_RS07535	COG0740	serine-type endopeptidase activity
TCUR_RS07540	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
TCUR_RS07545	COG2197	response regulator
TCUR_RS07560	COG0525	valine-tRNA ligase activity
TCUR_RS07565	COG0285	dihydrofolate synthase activity
TCUR_RS07575	COG0105	UTP biosynthetic process
TCUR_RS07580	COG1077	Cell shape determining protein MreB Mrl
TCUR_RS07595	COG0768	penicillin binding
TCUR_RS07600	COG0772	Belongs to the SEDS family
TCUR_RS07615	COG1530	ribonuclease E activity
TCUR_RS07620	COG0261	This protein binds to 23S rRNA in the presence of protein L20
TCUR_RS07625	COG0211	Belongs to the bacterial ribosomal protein bL27 family
TCUR_RS07630	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
TCUR_RS07635	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
TCUR_RS07640	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
TCUR_RS07645	COG0501	Belongs to the peptidase M48B family
TCUR_RS07650	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
TCUR_RS07655	COG0799	negative regulation of ribosome biogenesis
TCUR_RS07705	COG1683	Conserved Protein
TCUR_RS07710	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
TCUR_RS07715	COG1028	Short-chain dehydrogenase reductase Sdr
TCUR_RS07780	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
TCUR_RS07790	COG1595	DNA-templated transcription, initiation
TCUR_RS07800	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
TCUR_RS07805	COG2267	carboxylic ester hydrolase activity
TCUR_RS07815	COG0318	PFAM AMP-dependent synthetase and ligase
TCUR_RS07820	COG0495	leucyl-tRNA aminoacylation
TCUR_RS07825	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
TCUR_RS07830	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
TCUR_RS07835	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
TCUR_RS07840	COG0656	L-ascorbic acid biosynthetic process
TCUR_RS07860	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
TCUR_RS07865	COG0464	growth
TCUR_RS07915	COG3903	Transcriptional regulator
TCUR_RS07915	COG3629	intracellular signal transduction
TCUR_RS07930	COG2770	Histidine kinase
TCUR_RS07930	COG2208	phosphoserine phosphatase activity
TCUR_RS07935	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
TCUR_RS07945	COG3022	response to hydroperoxide
TCUR_RS07960	COG0531	amino acid
TCUR_RS07980	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
TCUR_RS07990	COG1131	(ABC) transporter
TCUR_RS08000	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
TCUR_RS08005	COG4585	Histidine kinase
TCUR_RS08015	COG0514	ATP-dependent DNA helicase (RecQ)
TCUR_RS08025	COG0045	succinate-CoA ligase (ADP-forming) activity
TCUR_RS08025	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
TCUR_RS08025	COG1042	CoA-binding domain protein
TCUR_RS08080	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
TCUR_RS08085	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
TCUR_RS08100	COG2267	carboxylic ester hydrolase activity
TCUR_RS08105	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
TCUR_RS08135	COG0572	uridine kinase
TCUR_RS08140	COG2197	response regulator
TCUR_RS08145	COG4585	Histidine kinase
TCUR_RS08150	COG3268	Saccharopine dehydrogenase
TCUR_RS08155	COG0583	DNA-binding transcription factor activity
TCUR_RS08160	COG1850	ribulose-bisphosphate carboxylase activity
TCUR_RS08165	COG4451	ribulose bisphosphate carboxylase, small
TCUR_RS08170	COG0464	growth
TCUR_RS08180	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
TCUR_RS08210	COG1619	proteins homologs of microcin C7 resistance protein MccF
TCUR_RS08220	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
TCUR_RS08245	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
TCUR_RS08265	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
TCUR_RS08285	COG0659	secondary active sulfate transmembrane transporter activity
TCUR_RS08295	COG1881	PFAM PEBP family protein
TCUR_RS08300	COG1252	NADH dehydrogenase
TCUR_RS08315	COG3402	PFAM membrane-flanked domain
TCUR_RS08340	COG0739	heme binding
TCUR_RS08345	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
TCUR_RS08360	COG0745	RESPONSE REGULATOR receiver
TCUR_RS08365	COG2205	protein histidine kinase activity
TCUR_RS08395	COG0525	valine-tRNA ligase activity
TCUR_RS08400	COG0706	membrane insertase activity
TCUR_RS08410	COG0756	dUTP diphosphatase activity
TCUR_RS08435	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
TCUR_RS08440	COG0569	domain protein
TCUR_RS08450	COG0569	domain protein
TCUR_RS08455	COG0531	amino acid
TCUR_RS08460	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
TCUR_RS08500	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
TCUR_RS08520	COG0318	PFAM AMP-dependent synthetase and ligase
TCUR_RS08525	COG1280	lysine exporter protein (LysE YggA)
TCUR_RS08565	COG2723	6-phospho-beta-galactosidase activity
TCUR_RS08570	COG0395	ABC-type sugar transport system, permease component
TCUR_RS08595	COG0366	Alpha amylase catalytic
TCUR_RS08610	COG0129	dihydroxy-acid dehydratase activity
TCUR_RS08615	COG0837	glucose binding
TCUR_RS08620	COG0800	Aldolase
TCUR_RS08630	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
TCUR_RS08630	COG0515	serine threonine protein kinase
TCUR_RS08645	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
TCUR_RS08660	COG3663	DNA glycosylase
TCUR_RS08670	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
TCUR_RS08675	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
TCUR_RS08685	COG0493	'glutamate synthase
TCUR_RS08690	COG0531	amino acid
TCUR_RS08695	COG1024	Enoyl-CoA hydratase
TCUR_RS08695	COG1250	3-hydroxyacyl-CoA dehydrogenase
TCUR_RS08700	COG0183	Belongs to the thiolase family
TCUR_RS08715	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
TCUR_RS08725	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
TCUR_RS08730	COG3253	May function as heme-dependent peroxidase
TCUR_RS08740	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
TCUR_RS08745	COG3540	Alkaline phosphatase
TCUR_RS08755	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
TCUR_RS08760	COG1595	DNA-templated transcription, initiation
TCUR_RS08810	COG1960	acyl-CoA dehydrogenase activity
TCUR_RS08830	COG0175	sulfate reduction
TCUR_RS08855	COG2409	Drug exporters of the RND superfamily
TCUR_RS08910	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
TCUR_RS08910	COG1116	anion transmembrane transporter activity
TCUR_RS08915	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
TCUR_RS08935	COG1132	(ABC) transporter
TCUR_RS08940	COG1316	TRANSCRIPTIONal
TCUR_RS08950	COG0386	Belongs to the glutathione peroxidase family
TCUR_RS08980	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
TCUR_RS09020	COG0318	PFAM AMP-dependent synthetase and ligase
TCUR_RS09035	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
TCUR_RS09035	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
TCUR_RS09060	COG2072	flavoprotein involved in K transport
TCUR_RS09065	COG1597	lipid kinase activity
TCUR_RS09085	COG3552	Protein containing von Willebrand factor type A (VWA) domain
TCUR_RS09095	COG0714	Associated with various cellular activities
TCUR_RS09155	COG0489	protein tyrosine kinase activity
TCUR_RS09185	COG1804	L-carnitine dehydratase bile acid-inducible protein F
TCUR_RS09190	COG0183	Belongs to the thiolase family
TCUR_RS09200	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
TCUR_RS09230	COG0778	Nitroreductase
TCUR_RS09255	COG0443	Heat shock 70 kDa protein
TCUR_RS09270	COG0235	Class ii aldolase
TCUR_RS09280	COG1960	acyl-CoA dehydrogenase activity
TCUR_RS09290	COG2205	protein histidine kinase activity
TCUR_RS09305	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
TCUR_RS09320	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
TCUR_RS09325	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
TCUR_RS09330	COG3251	PFAM MbtH domain protein
TCUR_RS09340	COG0438	transferase activity, transferring glycosyl groups
TCUR_RS09360	COG0668	transmembrane transport
TCUR_RS09405	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
TCUR_RS09410	COG0494	nUDIX hydrolase
TCUR_RS09425	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
TCUR_RS09445	COG0420	3'-5' exonuclease activity
TCUR_RS09450	COG0419	ATPase involved in DNA repair
TCUR_RS09480	COG0515	serine threonine protein kinase
TCUR_RS09510	COG2315	Protein conserved in bacteria
TCUR_RS09540	COG3304	Inner membrane component domain
TCUR_RS09550	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
TCUR_RS09655	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
TCUR_RS09675	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
TCUR_RS09685	COG1764	response to oxidative stress
TCUR_RS09710	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
TCUR_RS09730	COG0235	Class ii aldolase
TCUR_RS09730	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
TCUR_RS09735	COG0477	Major facilitator Superfamily
TCUR_RS09745	COG1960	acyl-CoA dehydrogenase activity
TCUR_RS09760	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
TCUR_RS09765	COG1309	transcriptional regulator
TCUR_RS09790	COG0588	phosphoglycerate mutase activity
TCUR_RS09810	COG1643	Atp-dependent helicase
TCUR_RS09815	COG3467	pyridoxamine 5'-phosphate
TCUR_RS09850	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
TCUR_RS09850	COG1672	PFAM Archaeal ATPase
TCUR_RS09855	COG1556	Lactate utilization protein
TCUR_RS09860	COG1139	Iron-sulfur cluster binding protein
TCUR_RS09865	COG0247	lactate metabolic process
TCUR_RS09870	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
TCUR_RS09910	COG0477	Major facilitator Superfamily
TCUR_RS09920	COG0248	Ppx GppA phosphatase
TCUR_RS10050	COG0501	Belongs to the peptidase M48B family
TCUR_RS10085	COG0517	IMP dehydrogenase activity
TCUR_RS10085	COG0516	GMP reductase activity
TCUR_RS10120	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
TCUR_RS10120	COG0512	Glutamine amidotransferase of anthranilate synthase
TCUR_RS10125	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
TCUR_RS10155	COG1028	Short-chain dehydrogenase reductase Sdr
TCUR_RS10200	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
TCUR_RS10205	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
TCUR_RS10210	COG0829	nickel cation binding
TCUR_RS10215	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
TCUR_RS10220	COG0830	nickel cation binding
TCUR_RS10240	COG0831	urea catabolic process
TCUR_RS10245	COG4413	Urea transporter
TCUR_RS10300	COG0640	Transcriptional regulator
TCUR_RS10320	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
TCUR_RS10360	COG0477	Major facilitator Superfamily
TCUR_RS10365	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
TCUR_RS10390	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
TCUR_RS10395	COG1560	Kdo2-lipid A biosynthetic process
TCUR_RS10400	COG0438	transferase activity, transferring glycosyl groups
TCUR_RS10415	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
TCUR_RS10425	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
TCUR_RS10430	COG0217	transcriptional regulatory protein
TCUR_RS10435	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
TCUR_RS10440	COG0632	four-way junction helicase activity
TCUR_RS10445	COG2255	four-way junction helicase activity
TCUR_RS10455	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
TCUR_RS10460	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
TCUR_RS10465	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
TCUR_RS10470	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
TCUR_RS10480	COG1196	nuclear chromosome segregation
TCUR_RS10485	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
TCUR_RS10490	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TCUR_RS10495	COG0124	histidyl-tRNA synthetase
TCUR_RS10500	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
TCUR_RS10510	COG0017	Asparaginyl-tRNA synthetase
TCUR_RS10525	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
TCUR_RS10560	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
TCUR_RS10565	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
TCUR_RS10575	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
TCUR_RS10580	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
TCUR_RS10585	COG0291	Belongs to the bacterial ribosomal protein bL35 family
TCUR_RS10590	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
TCUR_RS10595	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
TCUR_RS10605	COG4191	Histidine kinase
TCUR_RS10610	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
TCUR_RS10615	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TCUR_RS10615	COG0072	phenylalanine-tRNA ligase activity
TCUR_RS10620	COG0488	(ABC) transporter
TCUR_RS10640	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
TCUR_RS10645	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
TCUR_RS10650	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
TCUR_RS10655	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
TCUR_RS10660	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
TCUR_RS10665	COG1438	arginine binding
TCUR_RS10670	COG0137	argininosuccinate synthase activity
TCUR_RS10675	COG0165	Argininosuccinate lyase
TCUR_RS10680	COG2094	Belongs to the DNA glycosylase MPG family
TCUR_RS10685	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
TCUR_RS10730	COG0647	UMP catabolic process
TCUR_RS10750	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
TCUR_RS10755	COG0497	DNA recombination
TCUR_RS10780	COG0438	transferase activity, transferring glycosyl groups
TCUR_RS10785	COG1960	acyl-CoA dehydrogenase activity
TCUR_RS10795	COG0542	response to heat
TCUR_RS10835	COG3383	formate dehydrogenase (NAD+) activity
TCUR_RS10845	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TCUR_RS10855	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
TCUR_RS10865	COG0723	plastoquinol--plastocyanin reductase activity
TCUR_RS10870	COG0322	excinuclease ABC activity
TCUR_RS10875	COG1660	Displays ATPase and GTPase activities
TCUR_RS10885	COG1481	regulation of sporulation
TCUR_RS10890	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
TCUR_RS10895	COG0126	phosphoglycerate kinase activity
TCUR_RS10900	COG0149	triose-phosphate isomerase activity
TCUR_RS10905	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
TCUR_RS10955	COG0166	Belongs to the GPI family
TCUR_RS10960	COG0166	Belongs to the GPI family
TCUR_RS10965	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
TCUR_RS10970	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
TCUR_RS10975	COG0109	protoheme IX farnesyltransferase activity
TCUR_RS10990	COG5006	permease, DMT superfamily
TCUR_RS11000	COG1131	(ABC) transporter
TCUR_RS11005	COG0531	amino acid
TCUR_RS11035	COG0396	ATPase activity
TCUR_RS11040	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
TCUR_RS11045	COG0822	iron-sulfur transferase activity
TCUR_RS11050	COG2151	metal-sulfur cluster biosynthetic enzyme
TCUR_RS11060	COG4585	Histidine kinase
TCUR_RS11065	COG2197	response regulator
TCUR_RS11090	COG0488	(ABC) transporter
TCUR_RS11100	COG1024	Enoyl-CoA hydratase
TCUR_RS11105	COG1132	(ABC) transporter
TCUR_RS11115	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
TCUR_RS11130	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
TCUR_RS11135	COG2364	Membrane
TCUR_RS11200	COG2814	Major facilitator Superfamily
TCUR_RS11215	COG1690	Belongs to the RtcB family
TCUR_RS11220	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
TCUR_RS11225	COG0746	molybdenum cofactor guanylyltransferase activity
TCUR_RS11250	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
TCUR_RS11260	COG3360	Dodecin
TCUR_RS11275	COG1028	Short-chain dehydrogenase reductase Sdr
TCUR_RS11295	COG0667	Aldo Keto reductase
TCUR_RS11300	COG1968	undecaprenyl-diphosphatase activity
TCUR_RS11325	COG0215	cysteine-tRNA ligase activity
TCUR_RS11330	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
TCUR_RS11345	COG1410	methionine synthase
TCUR_RS11345	COG0646	methionine synthase
TCUR_RS11350	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
TCUR_RS11360	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TCUR_RS11365	COG0747	negative chemotaxis
TCUR_RS11380	COG4608	Belongs to the ABC transporter superfamily
TCUR_RS11385	COG1136	(ABC) transporter
TCUR_RS11385	COG0577	efflux transmembrane transporter activity
TCUR_RS11390	COG1136	(ABC) transporter
TCUR_RS11395	COG2197	response regulator
TCUR_RS11400	COG4585	Histidine kinase
TCUR_RS11410	COG0517	IMP dehydrogenase activity
TCUR_RS11410	COG1994	Peptidase M50
TCUR_RS11420	COG1222	aaa ATPase
TCUR_RS11425	COG4122	O-methyltransferase activity
TCUR_RS11440	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
TCUR_RS11445	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
TCUR_RS11450	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
TCUR_RS11465	COG2378	regulation of single-species biofilm formation
TCUR_RS11470	COG2378	regulation of single-species biofilm formation
TCUR_RS11485	COG0805	protein transport
TCUR_RS11495	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
TCUR_RS11510	COG1653	transport
TCUR_RS11515	COG1175	transmembrane transport
TCUR_RS11520	COG0395	ABC-type sugar transport system, permease component
TCUR_RS11550	COG1522	sequence-specific DNA binding
TCUR_RS11570	COG1960	acyl-CoA dehydrogenase activity
TCUR_RS11580	COG1509	lysine 2,3-aminomutase activity
TCUR_RS11585	COG0604	alcohol dehydrogenase
TCUR_RS11615	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
TCUR_RS11620	COG1607	acyl-coa hydrolase
TCUR_RS11630	COG1216	Glycosyl transferase, family 2
TCUR_RS11635	COG3030	protein affecting phage T7 exclusion by the F plasmid
TCUR_RS11650	COG0640	Transcriptional regulator
TCUR_RS11695	COG0535	radical SAM domain protein
TCUR_RS11700	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
TCUR_RS11730	COG1028	Short-chain dehydrogenase reductase Sdr
TCUR_RS11745	COG0584	glycerophosphoryl diester phosphodiesterase
TCUR_RS11750	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
TCUR_RS11760	COG2304	oxidoreductase activity
TCUR_RS11770	COG0714	Associated with various cellular activities
TCUR_RS11785	COG0671	phosphoesterase, PA-phosphatase related
TCUR_RS11790	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
TCUR_RS11795	COG4974	Belongs to the 'phage' integrase family
TCUR_RS11820	COG4974	Belongs to the 'phage' integrase family
TCUR_RS11830	COG2313	pseudouridylate synthase activity
TCUR_RS11855	COG1649	PFAM Uncharacterised BCR, COG1649
TCUR_RS11865	COG1169	isochorismate synthase
TCUR_RS11880	COG2365	Tyrosine phosphatase family
TCUR_RS11885	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
TCUR_RS11890	COG4948	Mandelate Racemase Muconate Lactonizing
TCUR_RS11905	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
TCUR_RS11935	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
TCUR_RS11935	COG2146	nitrite reductase [NAD(P)H] activity
TCUR_RS11940	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
TCUR_RS11945	COG0243	molybdopterin cofactor binding
TCUR_RS11960	COG2223	nitrite transmembrane transporter activity
TCUR_RS11985	COG3226	Transcriptional regulator
TCUR_RS11990	COG1556	Lactate utilization protein
TCUR_RS11995	COG1139	Iron-sulfur cluster binding protein
TCUR_RS12000	COG0247	lactate metabolic process
TCUR_RS12020	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
TCUR_RS12020	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
TCUR_RS12060	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
TCUR_RS12070	COG0494	nUDIX hydrolase
TCUR_RS12075	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
TCUR_RS12085	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
TCUR_RS12090	COG1522	sequence-specific DNA binding
TCUR_RS12110	COG0753	catalase activity
TCUR_RS12115	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
TCUR_RS12130	COG2264	protein methyltransferase activity
TCUR_RS12155	COG1414	Transcriptional regulator
TCUR_RS12175	COG0438	transferase activity, transferring glycosyl groups
TCUR_RS12180	COG1309	transcriptional regulator
TCUR_RS12195	COG0657	acetylesterase activity
TCUR_RS12200	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
TCUR_RS12210	COG4585	Histidine kinase
TCUR_RS12215	COG2197	response regulator
TCUR_RS12240	COG0243	molybdopterin cofactor binding
TCUR_RS12285	COG0754	glutathionylspermidine amidase activity
TCUR_RS12300	COG1960	acyl-CoA dehydrogenase activity
TCUR_RS12305	COG0463	Glycosyl transferase, family 2
TCUR_RS12330	COG4555	ABC transporter
TCUR_RS12340	COG1280	lysine exporter protein (LysE YggA)
TCUR_RS12345	COG2076	Multidrug Resistance protein
TCUR_RS12360	COG1960	acyl-CoA dehydrogenase activity
TCUR_RS12405	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
TCUR_RS12410	COG0657	acetylesterase activity
TCUR_RS12415	COG1960	acyl-CoA dehydrogenase activity
TCUR_RS12565	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
TCUR_RS12605	COG3903	Transcriptional regulator
TCUR_RS12605	COG3629	intracellular signal transduction
TCUR_RS12610	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
TCUR_RS12660	COG1070	Carbohydrate kinase
TCUR_RS12680	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
TCUR_RS12680	COG0574	Belongs to the PEP-utilizing enzyme family
TCUR_RS12685	COG0318	PFAM AMP-dependent synthetase and ligase
TCUR_RS12700	COG0583	DNA-binding transcription factor activity
TCUR_RS12705	COG0477	Major facilitator Superfamily
TCUR_RS12750	COG2124	cytochrome p450
TCUR_RS12770	COG1024	Enoyl-CoA hydratase
TCUR_RS12790	COG2186	Transcriptional regulator
TCUR_RS12795	COG1946	Acyl-CoA thioesterase
TCUR_RS12815	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
TCUR_RS12820	COG3002	Belongs to the UPF0753 family
TCUR_RS12825	COG0659	secondary active sulfate transmembrane transporter activity
TCUR_RS12845	COG1960	acyl-CoA dehydrogenase activity
TCUR_RS12895	COG1376	ErfK ybiS ycfS ynhG family protein
TCUR_RS12905	COG0583	DNA-binding transcription factor activity
TCUR_RS12910	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
TCUR_RS12975	COG1316	TRANSCRIPTIONal
TCUR_RS12995	COG4948	Mandelate Racemase Muconate Lactonizing
TCUR_RS13025	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
TCUR_RS13035	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
TCUR_RS13050	COG2770	Histidine kinase
TCUR_RS13050	COG2208	phosphoserine phosphatase activity
TCUR_RS13055	COG5002	protein histidine kinase activity
TCUR_RS13055	COG0784	Response regulator, receiver
TCUR_RS13070	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
TCUR_RS13085	COG2183	response to ionizing radiation
TCUR_RS13105	COG3486	L-lysine 6-monooxygenase (NADPH) activity
TCUR_RS13115	COG0701	Predicted permease
TCUR_RS13170	COG1643	Atp-dependent helicase
TCUR_RS13180	COG0667	Aldo Keto reductase
TCUR_RS13195	COG4214	carbohydrate transport
TCUR_RS13205	COG4213	ABC transporter substrate-binding protein
TCUR_RS13255	COG1518	maintenance of DNA repeat elements
TCUR_RS13290	COG0300	oxidoreductase activity
TCUR_RS13305	COG1309	transcriptional regulator
TCUR_RS13315	COG1024	Enoyl-CoA hydratase
TCUR_RS13325	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
TCUR_RS13330	COG1024	Enoyl-CoA hydratase
TCUR_RS13340	COG0318	PFAM AMP-dependent synthetase and ligase
TCUR_RS13350	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
TCUR_RS13360	COG1960	acyl-CoA dehydrogenase activity
TCUR_RS13365	COG0318	PFAM AMP-dependent synthetase and ligase
TCUR_RS13375	COG0318	PFAM AMP-dependent synthetase and ligase
TCUR_RS13380	COG0318	PFAM AMP-dependent synthetase and ligase
TCUR_RS13390	COG1028	Short-chain dehydrogenase reductase Sdr
TCUR_RS13395	COG0183	Belongs to the thiolase family
TCUR_RS13410	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TCUR_RS13420	COG4172	Belongs to the ABC transporter superfamily
TCUR_RS13425	COG4166	transmembrane transport
TCUR_RS13430	COG1024	Enoyl-CoA hydratase
TCUR_RS13440	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
TCUR_RS13465	COG0667	Aldo Keto reductase
TCUR_RS13490	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
TCUR_RS13505	COG0488	(ABC) transporter
TCUR_RS13560	COG0438	transferase activity, transferring glycosyl groups
TCUR_RS13580	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
TCUR_RS13580	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
TCUR_RS13600	COG1028	Short-chain dehydrogenase reductase Sdr
TCUR_RS13620	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
TCUR_RS13655	COG4585	Histidine kinase
TCUR_RS13660	COG2197	response regulator
TCUR_RS13665	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
TCUR_RS13670	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
TCUR_RS13700	COG1960	acyl-CoA dehydrogenase activity
TCUR_RS13720	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
TCUR_RS13755	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
TCUR_RS13785	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
TCUR_RS13880	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
TCUR_RS13895	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
TCUR_RS13910	COG0725	ABC transporter, periplasmic molybdate-binding protein
TCUR_RS13930	COG1160	GTP binding
TCUR_RS13935	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
TCUR_RS13945	COG4401	Chorismate mutase type I
TCUR_RS13955	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
TCUR_RS13975	COG0494	nUDIX hydrolase
TCUR_RS13980	COG0504	CTP synthase activity
TCUR_RS14010	COG2070	2-Nitropropane dioxygenase
TCUR_RS14030	COG0556	nucleotide-excision repair
TCUR_RS14035	COG4585	Histidine kinase
TCUR_RS14040	COG0237	dephospho-CoA kinase activity
TCUR_RS14060	COG0726	polysaccharide deacetylase
TCUR_RS14070	COG2050	protein possibly involved in aromatic compounds catabolism
TCUR_RS14125	COG0693	protein deglycase activity
TCUR_RS14140	COG0069	glutamate synthase activity
TCUR_RS14140	COG0067	glutamate synthase
TCUR_RS14140	COG0070	glutamate synthase
TCUR_RS14175	COG0159	tryptophan synthase activity
TCUR_RS14180	COG0133	tryptophan synthase activity
TCUR_RS14185	COG0134	indole-3-glycerol-phosphate synthase activity
TCUR_RS14195	COG0745	RESPONSE REGULATOR receiver
TCUR_RS14205	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
TCUR_RS14210	COG1278	Cold shock
TCUR_RS14215	COG1132	(ABC) transporter
TCUR_RS14220	COG1132	(ABC) transporter
TCUR_RS14240	COG1960	acyl-CoA dehydrogenase activity
TCUR_RS14260	COG0107	imidazoleglycerol-phosphate synthase activity
TCUR_RS14265	COG0251	oxidation-reduction process
TCUR_RS14270	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
TCUR_RS14275	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
TCUR_RS14280	COG0131	Imidazoleglycerol-phosphate dehydratase
TCUR_RS14285	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
TCUR_RS14290	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
TCUR_RS14295	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
TCUR_RS14305	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
TCUR_RS14315	COG0587	DNA-directed DNA polymerase activity
TCUR_RS14330	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
TCUR_RS14360	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
TCUR_RS14370	COG1872	DUF167
TCUR_RS14375	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
TCUR_RS14400	COG1799	cell septum assembly
TCUR_RS14410	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
TCUR_RS14415	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
TCUR_RS14420	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
TCUR_RS14425	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
TCUR_RS14435	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
TCUR_RS14440	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
TCUR_RS14450	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
TCUR_RS14455	COG0768	penicillin binding
TCUR_RS14465	COG0275	rRNA processing
TCUR_RS14470	COG2001	Belongs to the MraZ family
TCUR_RS14475	COG0714	Associated with various cellular activities
TCUR_RS14495	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
TCUR_RS14505	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
TCUR_RS14510	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
TCUR_RS14515	COG0006	proline dipeptidase activity
TCUR_RS14520	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
TCUR_RS14525	COG1024	Enoyl-CoA hydratase
TCUR_RS14525	COG1250	3-hydroxyacyl-CoA dehydrogenase
TCUR_RS14545	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
TCUR_RS14550	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
TCUR_RS14555	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
TCUR_RS14560	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
TCUR_RS14580	COG2197	response regulator
TCUR_RS14585	COG4585	Histidine kinase
TCUR_RS14595	COG1131	(ABC) transporter
TCUR_RS14600	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
TCUR_RS14625	COG0542	response to heat
TCUR_RS14635	COG2233	PERMEase
TCUR_RS14650	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
TCUR_RS14655	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
TCUR_RS14660	COG2017	converts alpha-aldose to the beta-anomer
TCUR_RS14670	COG3608	succinylglutamate desuccinylase aspartoacylase
TCUR_RS14670	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
TCUR_RS14685	COG3608	succinylglutamate desuccinylase aspartoacylase
TCUR_RS14685	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
TCUR_RS14695	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
TCUR_RS14735	COG0154	amidase activity
TCUR_RS14760	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
TCUR_RS14765	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
TCUR_RS14770	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
TCUR_RS14770	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
TCUR_RS14780	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
TCUR_RS14785	COG0671	phosphoesterase, PA-phosphatase related
TCUR_RS14795	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
TCUR_RS14800	COG0242	peptide deformylase activity
TCUR_RS14810	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
TCUR_RS14815	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
TCUR_RS14825	COG1758	RNA polymerase activity
TCUR_RS14830	COG0194	GDP metabolic process
TCUR_RS14840	COG0284	orotidine-5'-phosphate decarboxylase activity
TCUR_RS14845	COG0167	dihydroorotate dehydrogenase activity
TCUR_RS14850	COG0543	2 iron, 2 sulfur cluster binding
TCUR_RS14855	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
TCUR_RS14860	COG0505	Belongs to the CarA family
TCUR_RS14865	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
TCUR_RS14870	COG0540	Belongs to the ATCase OTCase family
TCUR_RS14875	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
TCUR_RS14885	COG2814	Major facilitator Superfamily
TCUR_RS14900	COG0442	prolyl-tRNA aminoacylation
TCUR_RS14920	COG0456	acetyltransferase
TCUR_RS14930	COG0142	geranyltranstransferase activity
TCUR_RS14940	COG0352	thiamine-phosphate diphosphorylase activity
TCUR_RS14955	COG2022	thiamine diphosphate biosynthetic process
TCUR_RS14955	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
TCUR_RS14965	COG2022	thiamine diphosphate biosynthetic process
TCUR_RS14970	COG0515	serine threonine protein kinase
TCUR_RS14970	COG2815	serine threonine protein kinase
TCUR_RS14975	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
TCUR_RS14980	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
TCUR_RS14985	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
TCUR_RS14990	COG0697	spore germination
TCUR_RS15000	COG0301	tRNA thio-modification
TCUR_RS15005	COG0205	6-phosphofructokinase activity
TCUR_RS15025	COG1940	carbohydrate kinase activity
TCUR_RS15075	COG0438	transferase activity, transferring glycosyl groups
TCUR_RS15080	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
TCUR_RS15085	COG0723	plastoquinol--plastocyanin reductase activity
TCUR_RS15090	COG2010	Cytochrome c
TCUR_RS15095	COG1845	cytochrome c oxidase, subunit III
TCUR_RS15105	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
TCUR_RS15145	COG0501	Belongs to the peptidase M48B family
TCUR_RS15150	COG1376	ErfK ybiS ycfS ynhG family protein
TCUR_RS15160	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
TCUR_RS15165	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
TCUR_RS15180	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
TCUR_RS15190	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
TCUR_RS15210	COG0667	Aldo Keto reductase
TCUR_RS15225	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
TCUR_RS15230	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
TCUR_RS15235	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
TCUR_RS15250	COG3340	Belongs to the peptidase S51 family
TCUR_RS15255	COG0321	lipoyl(octanoyl) transferase activity
TCUR_RS15265	COG0393	Putative heavy-metal-binding
TCUR_RS15270	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
TCUR_RS15280	COG1714	RDD family
TCUR_RS15290	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
TCUR_RS15295	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
TCUR_RS15300	COG0174	glutamine synthetase
TCUR_RS15310	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
TCUR_RS15310	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
TCUR_RS15330	COG0477	Major facilitator Superfamily
TCUR_RS15335	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
TCUR_RS15350	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
TCUR_RS15375	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TCUR_RS15380	COG0318	PFAM AMP-dependent synthetase and ligase
TCUR_RS15390	COG3336	cytochrome c oxidase
TCUR_RS15410	COG2351	hydroxyisourate hydrolase activity
TCUR_RS15415	COG2252	PERMEase
TCUR_RS15420	COG1929	Belongs to the glycerate kinase type-1 family
TCUR_RS15430	COG0406	alpha-ribazole phosphatase activity
TCUR_RS15435	COG1937	Protein conserved in bacteria
TCUR_RS15450	COG0405	Gamma-glutamyltransferase
TCUR_RS15455	COG0531	amino acid
TCUR_RS15485	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
TCUR_RS15495	COG1881	PFAM PEBP family protein
TCUR_RS15515	COG1376	ErfK ybiS ycfS ynhG family protein
TCUR_RS15560	COG0477	Major facilitator Superfamily
TCUR_RS15585	COG0559	Belongs to the binding-protein-dependent transport system permease family
TCUR_RS15600	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
TCUR_RS15615	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
TCUR_RS15625	COG3279	Response regulator of the LytR AlgR family
TCUR_RS15630	COG3275	phosphorelay sensor kinase activity
TCUR_RS15645	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TCUR_RS15665	COG1011	Hydrolase
TCUR_RS15695	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
TCUR_RS15705	COG1358	cellular component organization or biogenesis
TCUR_RS15755	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
TCUR_RS15760	COG0358	DNA primase activity
TCUR_RS15780	COG0831	urea catabolic process
TCUR_RS15785	COG0832	Belongs to the urease beta subunit family
TCUR_RS15790	COG0804	urea catabolic process
TCUR_RS15800	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
TCUR_RS15805	COG0829	nickel cation binding
TCUR_RS15815	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
TCUR_RS15820	COG1595	DNA-templated transcription, initiation
TCUR_RS15840	COG0232	Belongs to the dGTPase family. Type 2 subfamily
TCUR_RS15850	COG0574	Belongs to the PEP-utilizing enzyme family
TCUR_RS15850	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
TCUR_RS15855	COG3387	PFAM Glycoside hydrolase 15-related
TCUR_RS15870	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
TCUR_RS15870	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
TCUR_RS15885	COG0423	glycine-tRNA ligase activity
TCUR_RS15905	COG1121	(ABC) transporter
TCUR_RS15910	COG1108	ABC-type Mn2 Zn2 transport systems permease components
TCUR_RS15920	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
TCUR_RS15925	COG1381	Involved in DNA repair and RecF pathway recombination
TCUR_RS15940	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
TCUR_RS15970	COG1834	amidinotransferase
TCUR_RS15980	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
TCUR_RS15995	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
TCUR_RS16005	COG0537	adenosine 5'-monophosphoramidase activity
TCUR_RS16025	COG0484	heat shock protein binding
TCUR_RS16030	COG1420	regulation of RNA biosynthetic process
TCUR_RS16075	COG0481	GTPase activity
TCUR_RS16080	COG0268	Binds directly to 16S ribosomal RNA
TCUR_RS16105	COG1596	polysaccharide export
TCUR_RS16105	COG1555	photosystem II stabilization
TCUR_RS16110	COG1228	amidohydrolase
TCUR_RS16115	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
TCUR_RS16120	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
TCUR_RS16125	COG0277	FAD linked oxidase domain protein
TCUR_RS16130	COG0277	FAD linked oxidase domain protein
TCUR_RS16135	COG0247	lactate metabolic process
TCUR_RS16175	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
TCUR_RS16180	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
TCUR_RS16195	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TCUR_RS16200	COG1126	abc transporter atp-binding protein
TCUR_RS16205	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
TCUR_RS16210	COG0765	amino acid transport
TCUR_RS16215	COG0765	amino acid transport
TCUR_RS16225	COG1418	mRNA catabolic process
TCUR_RS16235	COG1372	Participates in initiation and elongation during chromosome replication
TCUR_RS16235	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
TCUR_RS16260	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
TCUR_RS16265	COG0783	Belongs to the Dps family
TCUR_RS16270	COG1396	sequence-specific DNA binding
TCUR_RS16275	COG1546	Belongs to the CinA family
TCUR_RS16275	COG1058	Belongs to the CinA family
TCUR_RS16285	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TCUR_RS16295	COG1674	ftsk spoiiie
TCUR_RS16300	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
TCUR_RS16305	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
TCUR_RS16330	COG0477	Major facilitator Superfamily
TCUR_RS16340	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
TCUR_RS16355	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
TCUR_RS16360	COG1950	PFAM Membrane protein of
TCUR_RS16365	COG0612	Peptidase, M16
TCUR_RS16370	COG1185	polyribonucleotide nucleotidyltransferase activity
TCUR_RS16375	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
TCUR_RS16385	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
TCUR_RS16390	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
TCUR_RS16395	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
TCUR_RS16405	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
TCUR_RS16415	COG0779	Required for maturation of 30S ribosomal subunits
TCUR_RS16455	COG1960	acyl-CoA dehydrogenase activity
TCUR_RS16470	COG3485	protocatechuate 3,4-dioxygenase
TCUR_RS16475	COG3485	protocatechuate 3,4-dioxygenase
TCUR_RS16480	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
TCUR_RS16505	COG1309	transcriptional regulator
TCUR_RS16525	COG1515	deoxyribonuclease V activity
TCUR_RS16570	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
TCUR_RS16595	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
TCUR_RS16605	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
TCUR_RS16630	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
TCUR_RS16645	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
TCUR_RS16650	COG2154	pterin-4-alpha-carbinolamine dehydratase
TCUR_RS16665	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
TCUR_RS16695	COG2124	cytochrome p450
TCUR_RS16705	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
TCUR_RS16710	COG1177	transmembrane transport
TCUR_RS16715	COG1176	ABC-type spermidine putrescine transport system, permease component I
TCUR_RS16725	COG3842	ATPase activity
TCUR_RS16745	COG1121	(ABC) transporter
TCUR_RS16765	COG0820	rRNA (adenine-C2-)-methyltransferase activity
TCUR_RS16780	COG0233	cytoplasmic translational termination
TCUR_RS16785	COG0528	UMP kinase activity
TCUR_RS16790	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
TCUR_RS16795	COG0052	Belongs to the universal ribosomal protein uS2 family
TCUR_RS16815	COG0792	nuclease activity
TCUR_RS16835	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
TCUR_RS16840	COG0681	Belongs to the peptidase S26 family
TCUR_RS16845	COG0335	large ribosomal subunit rRNA binding
TCUR_RS16850	COG0336	Belongs to the RNA methyltransferase TrmD family
TCUR_RS16855	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
TCUR_RS16860	COG1837	Belongs to the UPF0109 family
TCUR_RS16875	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
TCUR_RS16895	COG1196	nuclear chromosome segregation
TCUR_RS16905	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
TCUR_RS16910	COG0571	ribonuclease III activity
TCUR_RS16915	COG0333	Belongs to the bacterial ribosomal protein bL32 family
TCUR_RS16925	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
TCUR_RS16930	COG0742	ribosomal rna small subunit methyltransferase
TCUR_RS16940	COG0227	Belongs to the bacterial ribosomal protein bL28 family
TCUR_RS16950	COG0351	phosphomethylpyrimidine kinase
TCUR_RS16980	COG0667	Aldo Keto reductase
TCUR_RS16990	COG1017	nitric oxide dioxygenase activity
TCUR_RS16990	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
TCUR_RS16995	COG1959	2 iron, 2 sulfur cluster binding
TCUR_RS17015	COG1309	transcriptional regulator
TCUR_RS17020	COG1024	Enoyl-CoA hydratase
TCUR_RS17035	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
TCUR_RS17045	COG1920	GTP binding
TCUR_RS17055	COG0776	regulation of translation
TCUR_RS17065	COG0066	3-isopropylmalate dehydratase activity
TCUR_RS17070	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
TCUR_RS17075	COG1414	Transcriptional regulator
TCUR_RS17105	COG4569	acetaldehyde dehydrogenase (acetylating) activity
TCUR_RS17110	COG3971	2-oxopent-4-enoate hydratase activity
TCUR_RS17115	COG1028	Short-chain dehydrogenase reductase Sdr
TCUR_RS17120	COG0183	Belongs to the thiolase family
TCUR_RS17125	COG0318	PFAM AMP-dependent synthetase and ligase
TCUR_RS17150	COG1960	acyl-CoA dehydrogenase activity
TCUR_RS17160	COG1960	acyl-CoA dehydrogenase activity
TCUR_RS17165	COG0318	PFAM AMP-dependent synthetase and ligase
TCUR_RS17200	COG1028	Short-chain dehydrogenase reductase Sdr
TCUR_RS17215	COG1960	acyl-CoA dehydrogenase activity
TCUR_RS17220	COG0183	Belongs to the thiolase family
TCUR_RS17230	COG1028	Short-chain dehydrogenase reductase Sdr
TCUR_RS17245	COG1309	transcriptional regulator
TCUR_RS17280	COG1960	acyl-CoA dehydrogenase activity
TCUR_RS17300	COG0318	PFAM AMP-dependent synthetase and ligase
TCUR_RS17315	COG1053	succinate dehydrogenase
TCUR_RS17325	COG0667	Aldo Keto reductase
TCUR_RS17340	COG1053	succinate dehydrogenase
TCUR_RS17345	COG2267	carboxylic ester hydrolase activity
TCUR_RS17350	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
TCUR_RS17360	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
TCUR_RS17380	COG2409	Drug exporters of the RND superfamily
TCUR_RS17405	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
TCUR_RS17420	COG0579	oxidoreductase
TCUR_RS17440	COG0179	Fumarylacetoacetate (FAA) hydrolase
TCUR_RS17460	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
TCUR_RS17465	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
TCUR_RS17470	COG0473	3-isopropylmalate dehydrogenase activity
TCUR_RS17495	COG4591	ABC-type transport system involved in lipoprotein release permease component
TCUR_RS17495	COG1136	(ABC) transporter
TCUR_RS17505	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
TCUR_RS17520	COG5001	Diguanylate cyclase
TCUR_RS17530	COG2133	pyrroloquinoline quinone binding
TCUR_RS17535	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
TCUR_RS17540	COG0154	amidase activity
TCUR_RS17545	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
TCUR_RS17560	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
TCUR_RS17565	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
TCUR_RS17580	COG0482	sulfurtransferase activity
TCUR_RS17595	COG1309	transcriptional regulator
TCUR_RS17610	COG0714	Associated with various cellular activities
TCUR_RS17615	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
TCUR_RS17645	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
TCUR_RS17650	COG4279	zinc finger
TCUR_RS17655	COG0058	SHG alpha-glucan phosphorylase activity
TCUR_RS17660	COG0366	Alpha amylase catalytic
TCUR_RS17670	COG3281	Trehalose synthase
TCUR_RS17730	COG2186	Transcriptional regulator
TCUR_RS17755	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
TCUR_RS17780	COG0616	signal peptide processing
TCUR_RS17785	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
TCUR_RS17790	COG0515	serine threonine protein kinase
TCUR_RS17795	COG1132	(ABC) transporter
TCUR_RS17800	COG1132	(ABC) transporter
TCUR_RS17805	COG2197	response regulator
TCUR_RS17810	COG1228	amidohydrolase
TCUR_RS17820	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
TCUR_RS17825	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
TCUR_RS17830	COG2986	histidine ammonia-lyase
TCUR_RS17840	COG1414	Transcriptional regulator
TCUR_RS17860	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
TCUR_RS17900	COG1174	glycine betaine transport
TCUR_RS17905	COG1174	glycine betaine transport
TCUR_RS17910	COG1125	glycine betaine transport
TCUR_RS17910	COG0517	IMP dehydrogenase activity
TCUR_RS17915	COG1609	Transcriptional regulator
TCUR_RS17920	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
TCUR_RS17925	COG0121	glutamine amidotransferase
TCUR_RS17930	COG1262	PFAM Formylglycine-generating sulfatase enzyme
TCUR_RS17945	COG1960	acyl-CoA dehydrogenase activity
TCUR_RS17950	COG1960	acyl-CoA dehydrogenase activity
TCUR_RS17955	COG1309	transcriptional regulator
TCUR_RS17960	COG1028	Short-chain dehydrogenase reductase Sdr
TCUR_RS17980	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
TCUR_RS17985	COG2124	cytochrome p450
TCUR_RS18000	COG0183	Belongs to the thiolase family
TCUR_RS18005	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TCUR_RS18015	COG0438	transferase activity, transferring glycosyl groups
TCUR_RS18020	COG2226	methyltransferase
TCUR_RS18075	COG1024	Enoyl-CoA hydratase
TCUR_RS18080	COG1028	Short-chain dehydrogenase reductase Sdr
TCUR_RS18095	COG0567	Dehydrogenase, E1 component
TCUR_RS18095	COG0508	dehydrogenase complex catalyzes the overall conversion of
TCUR_RS18105	COG1695	Transcriptional regulator
TCUR_RS18115	COG0604	alcohol dehydrogenase
TCUR_RS18120	COG1126	abc transporter atp-binding protein
TCUR_RS18125	COG0765	amino acid transport
TCUR_RS18130	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
TCUR_RS18165	COG2172	sigma factor antagonist activity
TCUR_RS18180	COG1597	lipid kinase activity
TCUR_RS18200	COG2188	Transcriptional regulator
TCUR_RS18205	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
TCUR_RS18210	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
TCUR_RS18225	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
TCUR_RS18230	COG0439	Biotin carboxylase
TCUR_RS18240	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
TCUR_RS18240	COG2199	diguanylate cyclase activity
TCUR_RS18250	COG5662	AntiSigma factor
TCUR_RS18255	COG1595	DNA-templated transcription, initiation
TCUR_RS18270	COG2135	peptidase activity
TCUR_RS18285	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
TCUR_RS18305	COG0483	inositol monophosphate 1-phosphatase activity
TCUR_RS18325	COG1028	Short-chain dehydrogenase reductase Sdr
TCUR_RS18335	COG0318	PFAM AMP-dependent synthetase and ligase
TCUR_RS18365	COG3480	Lon protease (S16) C-terminal proteolytic domain
TCUR_RS18380	COG1615	UPF0182 protein
TCUR_RS18420	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
TCUR_RS18440	COG1946	Acyl-CoA thioesterase
TCUR_RS18470	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
TCUR_RS18480	COG4264	IucA IucC family
TCUR_RS18490	COG2226	methyltransferase
TCUR_RS18495	COG0210	DNA helicase
TCUR_RS18510	COG1404	Belongs to the peptidase S8 family
TCUR_RS18565	COG2409	Drug exporters of the RND superfamily
TCUR_RS18595	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
TCUR_RS18680	COG2076	Multidrug Resistance protein
TCUR_RS18735	COG2124	cytochrome p450
TCUR_RS18745	COG2018	Roadblock/LC7 domain
TCUR_RS18760	COG0589	response to stress
TCUR_RS18770	COG1834	amidinotransferase
TCUR_RS18795	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
TCUR_RS18845	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
TCUR_RS18850	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
TCUR_RS18865	COG1309	transcriptional regulator
TCUR_RS18870	COG1309	transcriptional regulator
TCUR_RS18905	COG0750	zinc metalloprotease
TCUR_RS18920	COG0404	The glycine cleavage system catalyzes the degradation of glycine
TCUR_RS18925	COG0509	glycine decarboxylation via glycine cleavage system
TCUR_RS18930	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
TCUR_RS18970	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
TCUR_RS18975	COG1486	melibiose metabolic process
TCUR_RS19005	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
TCUR_RS19010	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
TCUR_RS19020	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
TCUR_RS19060	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
TCUR_RS19070	COG1335	isochorismatase
TCUR_RS19075	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
TCUR_RS19095	COG1678	Uncharacterized ACR, COG1678
TCUR_RS19115	COG1904	glucuronate isomerase
TCUR_RS19115	COG1102	Psort location Cytoplasmic, score
TCUR_RS19125	COG1131	(ABC) transporter
TCUR_RS19140	COG0183	Belongs to the thiolase family
TCUR_RS19170	COG0596	Alpha beta hydrolase
TCUR_RS19185	COG1250	3-hydroxyacyl-CoA dehydrogenase
TCUR_RS19200	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
TCUR_RS19215	COG1994	Peptidase M50
TCUR_RS19225	COG1012	belongs to the aldehyde dehydrogenase family
TCUR_RS19255	COG0355	proton-transporting ATP synthase activity, rotational mechanism
TCUR_RS19260	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
TCUR_RS19265	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
TCUR_RS19270	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
TCUR_RS19275	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
TCUR_RS19280	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
TCUR_RS19285	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
TCUR_RS19330	COG2890	protein-(glutamine-N5) methyltransferase activity
TCUR_RS19335	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
TCUR_RS19340	COG0254	rRNA binding
TCUR_RS19345	COG2197	response regulator
TCUR_RS19360	COG0083	homoserine kinase activity
TCUR_RS19365	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
TCUR_RS19370	COG0460	homoserine dehydrogenase
TCUR_RS19375	COG0019	diaminopimelate decarboxylase activity
TCUR_RS19395	COG0582	viral genome integration into host DNA
TCUR_RS19440	COG1028	Short-chain dehydrogenase reductase Sdr
TCUR_RS19450	COG0018	arginyl-trna synthetase
TCUR_RS19495	COG1309	transcriptional regulator
TCUR_RS19500	COG0028	Belongs to the TPP enzyme family
TCUR_RS19515	COG0515	serine threonine protein kinase
TCUR_RS19515	COG2815	serine threonine protein kinase
TCUR_RS19520	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
TCUR_RS19520	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
TCUR_RS19560	COG1028	Short-chain dehydrogenase reductase Sdr
TCUR_RS19565	COG1846	Transcriptional regulator
TCUR_RS19570	COG0318	PFAM AMP-dependent synthetase and ligase
TCUR_RS19605	COG2070	2-Nitropropane dioxygenase
TCUR_RS19615	COG0500	methyltransferase
TCUR_RS19630	COG4981	capsule polysaccharide biosynthetic process
TCUR_RS19640	COG1215	transferase activity, transferring glycosyl groups
TCUR_RS19650	COG0657	acetylesterase activity
TCUR_RS19655	COG1960	acyl-CoA dehydrogenase activity
TCUR_RS19680	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
TCUR_RS19685	COG3409	Peptidoglycan-binding domain 1 protein
TCUR_RS19685	COG0793	Belongs to the peptidase S41A family
TCUR_RS19695	COG2884	Cell division ATP-binding protein ftsE
TCUR_RS19710	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
TCUR_RS19720	COG2902	Dehydrogenase
TCUR_RS19730	COG0791	NLP P60 protein
TCUR_RS19730	COG0741	lytic transglycosylase activity
TCUR_RS19735	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TCUR_RS19745	COG1012	belongs to the aldehyde dehydrogenase family
TCUR_RS19755	COG1011	Hydrolase
TCUR_RS19765	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
TCUR_RS19770	COG1737	Transcriptional regulator
TCUR_RS19785	COG1472	Belongs to the glycosyl hydrolase 3 family
TCUR_RS19790	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
TCUR_RS19795	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
TCUR_RS19805	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
TCUR_RS19810	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
TCUR_RS19815	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
TCUR_RS19820	COG2188	Transcriptional regulator
TCUR_RS19825	COG1263	PTS System
TCUR_RS19835	COG0653	protein targeting
TCUR_RS19845	COG3214	Protein conserved in bacteria
TCUR_RS19855	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
TCUR_RS19860	COG1040	competence protein
TCUR_RS19865	COG5401	PFAM Sporulation and spore germination
TCUR_RS19870	COG5002	protein histidine kinase activity
TCUR_RS19870	COG5000	phosphorelay sensor kinase activity
TCUR_RS19875	COG0745	RESPONSE REGULATOR receiver
TCUR_RS19895	COG0714	Associated with various cellular activities
TCUR_RS19930	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
TCUR_RS19935	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
TCUR_RS19960	COG2222	sugar isomerase
TCUR_RS20000	COG0391	Required for morphogenesis under gluconeogenic growth conditions
TCUR_RS20005	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
TCUR_RS20005	COG0778	Nitroreductase
TCUR_RS20015	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
TCUR_RS20020	COG0583	DNA-binding transcription factor activity
TCUR_RS20035	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
TCUR_RS20040	COG2226	methyltransferase
TCUR_RS20050	COG3118	belongs to the thioredoxin family
TCUR_RS20085	COG0438	transferase activity, transferring glycosyl groups
TCUR_RS20105	COG1316	TRANSCRIPTIONal
TCUR_RS20110	COG3594	Acyltransferase
TCUR_RS20115	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
TCUR_RS20145	COG3973	AAA domain
TCUR_RS20165	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
TCUR_RS20180	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
TCUR_RS20195	COG1316	TRANSCRIPTIONal
TCUR_RS20215	COG1832	CoA-binding protein
TCUR_RS20235	COG2205	protein histidine kinase activity
TCUR_RS20240	COG0745	RESPONSE REGULATOR receiver
TCUR_RS20255	COG2193	ferroxidase activity
TCUR_RS20260	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
TCUR_RS20270	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
TCUR_RS20275	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
TCUR_RS20285	COG1432	Conserved Protein
TCUR_RS20360	COG1674	ftsk spoiiie
TCUR_RS20395	COG0640	Transcriptional regulator
TCUR_RS20420	COG2197	response regulator
TCUR_RS20445	COG2346	COG2346, Truncated hemoglobins
TCUR_RS20495	COG4770	biotin carboxylase activity
TCUR_RS20535	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
TCUR_RS20545	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
TCUR_RS20575	COG1744	ABC transporter substrate-binding protein PnrA-like
TCUR_RS20580	COG3845	ABC transporter
TCUR_RS20585	COG4603	Belongs to the binding-protein-dependent transport system permease family
TCUR_RS20590	COG1079	Belongs to the binding-protein-dependent transport system permease family
TCUR_RS20595	COG1028	Short-chain dehydrogenase reductase Sdr
TCUR_RS20615	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
TCUR_RS20615	COG1473	amidohydrolase
TCUR_RS20620	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
TCUR_RS20625	COG1686	Belongs to the peptidase S11 family
TCUR_RS20640	COG0180	Tryptophanyl-tRNA synthetase
TCUR_RS20650	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
TCUR_RS20665	COG0039	L-malate dehydrogenase activity
TCUR_RS20685	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
TCUR_RS20690	COG0138	bifunctional purine biosynthesis protein purh
TCUR_RS20720	COG0045	succinate-CoA ligase (ADP-forming) activity
TCUR_RS20745	COG2197	response regulator
TCUR_RS20805	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
TCUR_RS20815	COG0438	transferase activity, transferring glycosyl groups
TCUR_RS20830	COG0450	alkyl hydroperoxide reductase
TCUR_RS20835	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
TCUR_RS20850	COG0519	Catalyzes the synthesis of GMP from XMP
TCUR_RS20850	COG0518	GMP synthase (glutamine-hydrolyzing) activity
TCUR_RS20860	COG1012	belongs to the aldehyde dehydrogenase family
TCUR_RS20870	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
TCUR_RS20875	COG0516	GMP reductase activity
TCUR_RS20895	COG1595	DNA-templated transcription, initiation
TCUR_RS20900	COG0459	protein refolding
TCUR_RS20905	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
TCUR_RS20920	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
TCUR_RS20925	COG0456	acetyltransferase
TCUR_RS20930	COG0456	acetyltransferase
TCUR_RS20930	COG1214	PFAM Peptidase M22, glycoprotease
TCUR_RS20940	COG0802	atpase or kinase
TCUR_RS20950	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
TCUR_RS20960	COG0736	holo-[acyl-carrier-protein] synthase activity
TCUR_RS20980	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
TCUR_RS20985	COG1072	(Pantothenic acid kinase))
TCUR_RS21025	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
TCUR_RS21030	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
TCUR_RS21035	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
TCUR_RS21040	COG2340	Cysteine-rich secretory protein family
TCUR_RS21055	COG0101	tRNA pseudouridine synthase activity
TCUR_RS21060	COG0203	ribosomal protein L17
TCUR_RS21065	COG0202	RNA polymerase activity
TCUR_RS21070	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
TCUR_RS21075	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
TCUR_RS21080	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
TCUR_RS21085	COG0257	Belongs to the bacterial ribosomal protein bL36 family
TCUR_RS21090	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
TCUR_RS21100	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
TCUR_RS21115	COG0563	adenylate kinase activity
TCUR_RS21125	COG0200	Binds to the 23S rRNA
TCUR_RS21130	COG1841	ribosomal large subunit assembly
TCUR_RS21135	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
TCUR_RS21140	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
TCUR_RS21145	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
TCUR_RS21150	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
TCUR_RS21155	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
TCUR_RS21160	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
TCUR_RS21165	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
TCUR_RS21170	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
TCUR_RS21175	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
TCUR_RS21180	COG0255	Belongs to the universal ribosomal protein uL29 family
TCUR_RS21185	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
TCUR_RS21190	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
TCUR_RS21195	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
TCUR_RS21200	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
TCUR_RS21205	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
TCUR_RS21210	COG0089	rRNA binding
TCUR_RS21215	COG0088	Forms part of the polypeptide exit tunnel
TCUR_RS21220	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
TCUR_RS21225	COG0051	transcription antitermination factor activity, RNA binding
TCUR_RS21230	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
TCUR_RS21235	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
TCUR_RS21240	COG0049	tRNA binding
TCUR_RS21245	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
TCUR_RS21260	COG0577	efflux transmembrane transporter activity
TCUR_RS21260	COG1136	(ABC) transporter
TCUR_RS21265	COG1136	(ABC) transporter
TCUR_RS21265	COG0577	efflux transmembrane transporter activity
TCUR_RS21300	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
TCUR_RS21305	COG0085	RNA polymerase activity
TCUR_RS21330	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
TCUR_RS21355	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
TCUR_RS21360	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
TCUR_RS21365	COG1127	ABC transporter
TCUR_RS21370	COG0222	ribosome binding
TCUR_RS21375	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
TCUR_RS21390	COG0081	regulation of translation
TCUR_RS21395	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
TCUR_RS21405	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
TCUR_RS21415	COG0436	Aminotransferase
TCUR_RS21420	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
TCUR_RS21430	COG0812	UDP-N-acetylmuramate dehydrogenase activity
TCUR_RS21440	COG2030	dehydratase
TCUR_RS21445	COG0267	Belongs to the bacterial ribosomal protein bL33 family
TCUR_RS21470	COG1960	acyl-CoA dehydrogenase activity
TCUR_RS21515	COG1666	GTP binding
TCUR_RS21525	COG0024	Methionine aminopeptidase
TCUR_RS21530	COG0501	Belongs to the peptidase M48B family
TCUR_RS21535	COG1007	ATP synthesis coupled electron transport
TCUR_RS21550	COG0713	ATP synthesis coupled electron transport
TCUR_RS21560	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TCUR_RS21575	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TCUR_RS21580	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TCUR_RS21585	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TCUR_RS21600	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
TCUR_RS21600	COG0674	pyruvate-flavodoxin oxidoreductase activity
TCUR_RS21605	COG1013	pyruvate-flavodoxin oxidoreductase activity
TCUR_RS21610	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
TCUR_RS21625	COG0477	Major facilitator Superfamily
TCUR_RS21635	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
TCUR_RS21655	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
TCUR_RS21665	COG0142	geranyltranstransferase activity
TCUR_RS21680	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
TCUR_RS21685	COG0713	ATP synthesis coupled electron transport
TCUR_RS21695	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TCUR_RS21700	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
TCUR_RS21705	COG1034	ATP synthesis coupled electron transport
TCUR_RS21720	COG0649	NAD binding
TCUR_RS21725	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TCUR_RS21730	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TCUR_RS21745	COG2226	methyltransferase
TCUR_RS21780	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
TCUR_RS21785	COG1333	cytochrome c biogenesis protein
TCUR_RS21790	COG0785	Cytochrome C biogenesis protein
TCUR_RS21795	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
TCUR_RS21800	COG0406	alpha-ribazole phosphatase activity
TCUR_RS21810	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
TCUR_RS21815	COG0515	serine threonine protein kinase
TCUR_RS21830	COG0113	porphobilinogen synthase activity
TCUR_RS21840	COG0181	hydroxymethylbilane synthase activity
TCUR_RS21845	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
TCUR_RS21850	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
TCUR_RS21875	COG0560	Phosphoserine phosphatase
TCUR_RS21900	COG0123	including yeast histone deacetylase and acetoin utilization protein
TCUR_RS21915	COG1136	(ABC) transporter
TCUR_RS21915	COG0577	efflux transmembrane transporter activity
TCUR_RS21920	COG1136	(ABC) transporter
TCUR_RS21935	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
TCUR_RS21940	COG0506	proline dehydrogenase activity
TCUR_RS21945	COG1316	TRANSCRIPTIONal
TCUR_RS21955	COG1309	transcriptional regulator
TCUR_RS21960	COG1082	Xylose isomerase domain protein TIM barrel
TCUR_RS21965	COG0500	methyltransferase
TCUR_RS21970	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
TCUR_RS21975	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
TCUR_RS22015	COG0542	response to heat
TCUR_RS22035	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
TCUR_RS22050	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
TCUR_RS22055	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
TCUR_RS22060	COG0157	Belongs to the NadC ModD family
TCUR_RS22065	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
TCUR_RS22070	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
TCUR_RS22075	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
TCUR_RS22080	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
TCUR_RS22090	COG1136	(ABC) transporter
TCUR_RS22095	COG2197	response regulator
TCUR_RS22100	COG4585	Histidine kinase
TCUR_RS22120	COG0649	NAD binding
TCUR_RS22135	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
TCUR_RS22140	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
TCUR_RS22155	COG0302	gtp cyclohydrolase
TCUR_RS22165	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
TCUR_RS22170	COG0037	tRNA processing
TCUR_RS22180	COG2027	D-alanyl-D-alanine carboxypeptidase
TCUR_RS22185	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
TCUR_RS22190	COG3883	PFAM NLP P60 protein
TCUR_RS22190	COG0791	NLP P60 protein
TCUR_RS22245	COG0454	-acetyltransferase
TCUR_RS22325	COG1774	PSP1 C-terminal conserved region
TCUR_RS22340	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
TCUR_RS22345	COG0470	DNA polymerase III
TCUR_RS22350	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
TCUR_RS22355	COG1754	DNA topoisomerase type I activity
TCUR_RS22355	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
TCUR_RS22365	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
TCUR_RS22385	COG0596	Alpha beta hydrolase
TCUR_RS22390	COG2197	response regulator
TCUR_RS22395	COG4585	Histidine kinase
TCUR_RS22470	COG5297	Belongs to the glycosyl hydrolase family 6
TCUR_RS22510	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
TCUR_RS22520	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
TCUR_RS22525	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
TCUR_RS22540	COG0309	Hydrogenase expression formation protein (HypE)
TCUR_RS22545	COG0409	Hydrogenase expression formation protein
TCUR_RS22550	COG0298	carbon dioxide binding
TCUR_RS22575	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
TCUR_RS22615	COG3559	Exporter of polyketide antibiotics
TCUR_RS22620	COG1131	(ABC) transporter
TCUR_RS22650	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
TCUR_RS22655	COG1960	acyl-CoA dehydrogenase activity
TCUR_RS22660	COG1960	acyl-CoA dehydrogenase activity
TCUR_RS22665	COG1024	Enoyl-CoA hydratase
TCUR_RS22670	COG1028	Short-chain dehydrogenase reductase Sdr
TCUR_RS22675	COG0183	Belongs to the thiolase family
TCUR_RS22680	COG2186	Transcriptional regulator
TCUR_RS22685	COG1024	Enoyl-CoA hydratase
TCUR_RS22720	COG1320	monovalent cation:proton antiporter activity
TCUR_RS22725	COG2212	antiporter activity
TCUR_RS22730	COG1863	multisubunit Na H antiporter MnhE subunit
TCUR_RS22735	COG0651	ATP synthesis coupled electron transport
TCUR_RS22740	COG1006	Multisubunit Na H antiporter MnhC subunit
TCUR_RS22775	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
TCUR_RS22780	COG1804	L-carnitine dehydratase bile acid-inducible protein F
TCUR_RS22885	COG2197	response regulator
TCUR_RS22905	COG1253	flavin adenine dinucleotide binding
TCUR_RS22930	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
TCUR_RS22935	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
TCUR_RS22990	COG4566	intracellular signal transduction
TCUR_RS23025	COG2255	four-way junction helicase activity
TCUR_RS23080	COG3260	NADH ubiquinone oxidoreductase 20
TCUR_RS23090	COG0650	Formate hydrogenlyase subunit 4
TCUR_RS23100	COG0651	ATP synthesis coupled electron transport
TCUR_RS23105	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
TCUR_RS23105	COG3261	NADH dehydrogenase
TCUR_RS23130	COG4608	Belongs to the ABC transporter superfamily
TCUR_RS23135	COG0444	Belongs to the ABC transporter superfamily
TCUR_RS23145	COG0601	transmembrane transport
TCUR_RS23160	COG1742	UPF0060 membrane protein
TCUR_RS23165	COG0310	cobalt ion transport
TCUR_RS23170	COG1930	Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import
TCUR_RS23180	COG1122	ATPase activity
TCUR_RS23215	COG2197	response regulator
TCUR_RS23235	COG1024	Enoyl-CoA hydratase
TCUR_RS23245	COG0789	Transcriptional regulator
TCUR_RS23250	COG2814	Major facilitator Superfamily
TCUR_RS23255	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
TCUR_RS23265	COG1294	oxidase, subunit
TCUR_RS23270	COG1271	oxidase subunit
TCUR_RS23310	COG1595	DNA-templated transcription, initiation
TCUR_RS23315	COG2226	methyltransferase
TCUR_RS23315	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
TCUR_RS23315	COG0596	Alpha beta hydrolase
TCUR_RS23325	COG0642	Histidine kinase
TCUR_RS23355	COG1819	glycosyl
TCUR_RS23380	COG3339	Conserved Protein
TCUR_RS23390	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
TCUR_RS23415	COG1309	transcriptional regulator
TCUR_RS23440	COG0574	Belongs to the PEP-utilizing enzyme family
TCUR_RS23440	COG3848	Pyruvate phosphate dikinase
TCUR_RS23475	COG1595	DNA-templated transcription, initiation
TCUR_RS23515	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
TCUR_RS23520	COG0246	Mannitol dehydrogenase
TCUR_RS23545	COG2843	Capsule synthesis protein
TCUR_RS23550	COG1104	cysteine desulfurase activity
TCUR_RS23590	COG0243	molybdopterin cofactor binding
TCUR_RS23595	COG1262	PFAM Formylglycine-generating sulfatase enzyme
TCUR_RS23615	COG1119	ATPase activity
TCUR_RS23625	COG1714	RDD family
TCUR_RS23640	COG0560	Phosphoserine phosphatase
TCUR_RS23640	COG3830	Belongs to the UPF0237 family
TCUR_RS23655	COG2062	phosphohistidine phosphatase, SixA
TCUR_RS23660	COG2226	methyltransferase
TCUR_RS23665	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
TCUR_RS23670	COG2172	sigma factor antagonist activity
TCUR_RS23675	COG1366	Belongs to the anti-sigma-factor antagonist family
TCUR_RS23680	COG1205	dead DEAH box helicase
TCUR_RS23680	COG1111	helicase
TCUR_RS23740	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TCUR_RS23745	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
TCUR_RS23755	COG0596	Alpha beta hydrolase
TCUR_RS23785	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
TCUR_RS23790	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TCUR_RS23845	COG0019	diaminopimelate decarboxylase activity
TCUR_RS23860	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
TCUR_RS23865	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
TCUR_RS23885	COG2188	Transcriptional regulator
TCUR_RS23890	COG2188	Transcriptional regulator
TCUR_RS23910	COG0789	Transcriptional regulator
TCUR_RS23965	COG0464	growth
TCUR_RS23975	COG0604	alcohol dehydrogenase
TCUR_RS23975	COG3321	synthase
TCUR_RS23975	COG1028	Short-chain dehydrogenase reductase Sdr
TCUR_RS23985	COG1309	transcriptional regulator
TCUR_RS24010	COG1132	(ABC) transporter
TCUR_RS24095	COG1408	metallophosphoesterase
TCUR_RS24105	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
TCUR_RS24115	COG0003	Pfam Anion-transporting ATPase
TCUR_RS24145	COG0180	Tryptophanyl-tRNA synthetase
TCUR_RS24190	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
TCUR_RS24210	COG0590	tRNA wobble adenosine to inosine editing
TCUR_RS24220	COG0305	Participates in initiation and elongation during chromosome replication
TCUR_RS24225	COG0534	Mate efflux family protein
TCUR_RS24240	COG0359	binds to the 23S rRNA
TCUR_RS24245	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
TCUR_RS24255	COG0360	Binds together with S18 to 16S ribosomal RNA
TCUR_RS24285	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
TCUR_RS24310	COG0492	ferredoxin-NADP+ reductase activity
TCUR_RS24350	COG0617	tRNA 3'-terminal CCA addition
TCUR_RS24360	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
TCUR_RS24380	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
TCUR_RS24385	COG1181	Belongs to the D-alanine--D-alanine ligase family
TCUR_RS24395	COG1192	Involved in chromosome partitioning
TCUR_RS24405	COG0357	Ribosomal RNA small subunit methyltransferase G
TCUR_RS24415	COG0706	membrane insertase activity
TCUR_RS24420	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
TCUR_RS24425	COG0594	ribonuclease P activity
TCUR_RS24430	COG0230	Belongs to the bacterial ribosomal protein bL34 family
TCUR_RS24460	COG0515	serine threonine protein kinase
TCUR_RS24515	COG0515	serine threonine protein kinase
TCUR_RS24570	COG0464	growth
TCUR_RS24600	COG2409	Drug exporters of the RND superfamily
TCUR_RS24620	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
TCUR_RS24635	COG1404	Belongs to the peptidase S8 family
TCUR_RS24655	COG1715	Restriction endonuclease
TCUR_RS24660	COG1960	acyl-CoA dehydrogenase activity
TCUR_RS24675	COG1714	RDD family
TCUR_RS24695	COG0215	cysteine-tRNA ligase activity
TCUR_RS24735	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
TCUR_RS24855	COG0745	RESPONSE REGULATOR receiver
TCUR_RS24940	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
TCUR_RS24945	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
TCUR_RS24955	COG0515	serine threonine protein kinase
TCUR_RS24975	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
TCUR_RS24975	COG0515	serine threonine protein kinase
TCUR_RS24995	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
TCUR_RS25010	COG0604	alcohol dehydrogenase
TCUR_RS25010	COG3321	synthase
TCUR_RS25030	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
TCUR_RS25050	COG2319	Wd-40 repeat
TCUR_RS25050	COG5635	Nacht domain
TCUR_RS25080	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
TCUR_RS25080	COG0515	serine threonine protein kinase
TCUR_RS25130	COG1686	Belongs to the peptidase S11 family
TCUR_RS25135	COG0515	serine threonine protein kinase
TCUR_RS25135	COG2815	serine threonine protein kinase
TCUR_RS25195	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
TCUR_RS25195	COG2111	Na H antiporter
TCUR_RS25215	COG0515	serine threonine protein kinase
TCUR_RS25245	COG0195	Participates in both transcription termination and antitermination