locus-tag	class	description
TA_RS00025	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
TA_RS00030	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
TA_RS00050	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
TA_RS00055	COG0404	The glycine cleavage system catalyzes the degradation of glycine
TA_RS00100	COG2095	MarC family integral membrane protein
TA_RS00105	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
TA_RS00145	COG0667	Aldo Keto reductase
TA_RS00200	COG1763	Mo-molybdopterin cofactor biosynthetic process
TA_RS00230	COG0504	CTP synthase activity
TA_RS00235	COG3383	formate dehydrogenase (NAD+) activity
TA_RS00250	COG2814	Major facilitator Superfamily
TA_RS00290	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
TA_RS00295	COG1199	ATP-dependent helicase activity
TA_RS00300	COG0456	acetyltransferase
TA_RS00305	COG1812	S-adenosylmethionine synthetase (AdoMet synthetase)
TA_RS00310	COG0138	bifunctional purine biosynthesis protein purh
TA_RS00315	COG1024	Enoyl-CoA hydratase
TA_RS00325	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
TA_RS00330	COG1254	Belongs to the acylphosphatase family
TA_RS00340	COG4152	abc transporter atp-binding protein
TA_RS00350	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
TA_RS00375	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
TA_RS00380	COG0284	orotidine-5'-phosphate decarboxylase activity
TA_RS00390	COG1492	cobalamin metabolic process
TA_RS00415	COG0626	cystathionine gamma-synthase activity
TA_RS00425	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
TA_RS00440	COG4948	Mandelate Racemase Muconate Lactonizing
TA_RS00445	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TA_RS00460	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
TA_RS00470	COG0049	tRNA binding
TA_RS00475	COG0776	regulation of translation
TA_RS00495	COG0358	DNA primase activity
TA_RS00520	COG1304	FMN binding
TA_RS00525	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
TA_RS00535	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TA_RS00565	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
TA_RS00570	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
TA_RS00575	COG2890	protein-(glutamine-N5) methyltransferase activity
TA_RS00590	COG0538	isocitrate dehydrogenase activity
TA_RS00595	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
TA_RS00600	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
TA_RS00605	COG1024	Enoyl-CoA hydratase
TA_RS00615	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
TA_RS00635	COG1175	transmembrane transport
TA_RS00640	COG3833	ABC-type maltose transport systems, permease component
TA_RS00650	COG3842	ATPase activity
TA_RS00665	COG1741	Belongs to the pirin family
TA_RS00690	COG0366	Alpha amylase catalytic
TA_RS00695	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
TA_RS00705	COG0477	Major facilitator Superfamily
TA_RS00710	COG0531	amino acid
TA_RS00730	COG3833	ABC-type maltose transport systems, permease component
TA_RS00750	COG0531	amino acid
TA_RS00780	COG0477	Major facilitator Superfamily
TA_RS00795	COG0419	ATPase involved in DNA repair
TA_RS00855	COG0372	Belongs to the citrate synthase family
TA_RS00870	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TA_RS00880	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
TA_RS00885	COG0561	phosphatase activity
TA_RS00920	COG0393	Putative heavy-metal-binding
TA_RS00930	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
TA_RS00965	COG1028	Short-chain dehydrogenase reductase Sdr
TA_RS00975	COG1078	dGTPase activity
TA_RS00980	COG2267	carboxylic ester hydrolase activity
TA_RS01000	COG2181	nitrate reductase activity
TA_RS01000	COG0247	lactate metabolic process
TA_RS01010	COG2151	metal-sulfur cluster biosynthetic enzyme
TA_RS01020	COG0396	ATPase activity
TA_RS01025	COG0719	Fe-S assembly protein
TA_RS01030	COG0719	Fe-S assembly protein
TA_RS01035	COG1028	Short-chain dehydrogenase reductase Sdr
TA_RS01040	COG0423	glycine-tRNA ligase activity
TA_RS01050	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
TA_RS01080	COG0585	pseudouridine synthase activity
TA_RS01085	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
TA_RS01095	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
TA_RS01105	COG0516	GMP reductase activity
TA_RS01105	COG0517	IMP dehydrogenase activity
TA_RS01115	COG0697	spore germination
TA_RS01140	COG0477	Major facilitator Superfamily
TA_RS01145	COG1131	(ABC) transporter
TA_RS01160	COG0412	Dienelactone hydrolase
TA_RS01165	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TA_RS01170	COG1960	acyl-CoA dehydrogenase activity
TA_RS01195	COG1131	(ABC) transporter
TA_RS01205	COG1619	proteins homologs of microcin C7 resistance protein MccF
TA_RS01215	COG2078	PFAM AMMECR1 domain protein
TA_RS01215	COG3885	ferrous iron binding
TA_RS01225	COG1228	amidohydrolase
TA_RS01230	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
TA_RS01245	COG2986	histidine ammonia-lyase
TA_RS01270	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
TA_RS01280	COG4948	Mandelate Racemase Muconate Lactonizing
TA_RS01290	COG1028	Short-chain dehydrogenase reductase Sdr
TA_RS01295	COG2814	Major facilitator Superfamily
TA_RS01315	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TA_RS01325	COG1027	Aspartate ammonia-lyase
TA_RS01330	COG0674	pyruvate-flavodoxin oxidoreductase activity
TA_RS01330	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
TA_RS01335	COG1013	pyruvate-flavodoxin oxidoreductase activity
TA_RS01350	COG0601	transmembrane transport
TA_RS01355	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TA_RS01360	COG0444	Belongs to the ABC transporter superfamily
TA_RS01365	COG4608	Belongs to the ABC transporter superfamily
TA_RS01375	COG0601	transmembrane transport
TA_RS01385	COG4172	Belongs to the ABC transporter superfamily
TA_RS01415	COG4166	transmembrane transport
TA_RS01420	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
TA_RS01455	COG0018	arginyl-trna synthetase
TA_RS01460	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
TA_RS01470	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
TA_RS01475	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
TA_RS01480	COG3387	PFAM Glycoside hydrolase 15-related
TA_RS01485	COG0667	Aldo Keto reductase
TA_RS01495	COG2239	Acts as a magnesium transporter
TA_RS01505	COG1250	3-hydroxyacyl-CoA dehydrogenase
TA_RS01510	COG0318	PFAM AMP-dependent synthetase and ligase
TA_RS01520	COG1960	acyl-CoA dehydrogenase activity
TA_RS01525	COG1960	acyl-CoA dehydrogenase activity
TA_RS01530	COG0183	Belongs to the thiolase family
TA_RS01555	COG0308	aminopeptidase N
TA_RS01560	COG0009	L-threonylcarbamoyladenylate synthase
TA_RS01565	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
TA_RS01595	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
TA_RS01600	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
TA_RS01605	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
TA_RS01610	COG2131	deaminase
TA_RS01615	COG0149	triose-phosphate isomerase activity
TA_RS01660	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
TA_RS01675	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
TA_RS01685	COG0644	oxidoreductase
TA_RS01695	COG2086	electron transfer activity
TA_RS01700	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
TA_RS01705	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
TA_RS01720	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
TA_RS01725	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
TA_RS01730	COG2271	Major facilitator Superfamily
TA_RS01735	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
TA_RS01760	COG0438	transferase activity, transferring glycosyl groups
TA_RS01775	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
TA_RS01805	COG0531	amino acid
TA_RS01815	COG0183	Belongs to the thiolase family
TA_RS01825	COG1051	belongs to the nudix hydrolase family
TA_RS01825	COG1056	cytidyltransferase-related domain
TA_RS01835	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
TA_RS01845	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
TA_RS01855	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
TA_RS01860	COG0081	regulation of translation
TA_RS01865	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
TA_RS01960	COG2153	protein acetylation
TA_RS02045	COG0085	RNA polymerase activity
TA_RS02055	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
TA_RS02090	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
TA_RS02115	COG0167	dihydroorotate dehydrogenase activity
TA_RS02145	COG2814	Major facilitator Superfamily
TA_RS02150	COG1846	Transcriptional regulator
TA_RS02165	COG0493	'glutamate synthase
TA_RS02190	COG0656	L-ascorbic acid biosynthetic process
TA_RS02195	COG1584	GPR1 FUN34 yaaH family protein
TA_RS02200	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TA_RS02210	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
TA_RS02220	COG3383	formate dehydrogenase (NAD+) activity
TA_RS02230	COG0531	amino acid
TA_RS02240	COG2086	electron transfer activity
TA_RS02265	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
TA_RS02275	COG0109	protoheme IX farnesyltransferase activity
TA_RS02285	COG0003	Pfam Anion-transporting ATPase
TA_RS02295	COG1024	Enoyl-CoA hydratase
TA_RS02300	COG1028	Short-chain dehydrogenase reductase Sdr
TA_RS02310	COG2271	Major facilitator Superfamily
TA_RS02315	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
TA_RS02320	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
TA_RS02325	COG0051	transcription antitermination factor activity, RNA binding
TA_RS02330	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
TA_RS02355	COG0542	response to heat
TA_RS02360	COG2814	Major facilitator Superfamily
TA_RS02365	COG2379	hydroxypyruvate reductase
TA_RS02370	COG1335	isochorismatase
TA_RS02385	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
TA_RS02400	COG1515	deoxyribonuclease V activity
TA_RS02410	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
TA_RS02410	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
TA_RS02415	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
TA_RS02420	COG1703	isobutyryl-CoA mutase activity
TA_RS02425	COG0693	protein deglycase activity
TA_RS02440	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
TA_RS02445	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
TA_RS02450	COG2409	Drug exporters of the RND superfamily
TA_RS02465	COG0450	alkyl hydroperoxide reductase
TA_RS02480	COG1250	3-hydroxyacyl-CoA dehydrogenase
TA_RS02485	COG1573	uracil-dna glycosylase
TA_RS02490	COG1914	H( )-stimulated, divalent metal cation uptake system
TA_RS02495	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
TA_RS02505	COG1028	Short-chain dehydrogenase reductase Sdr
TA_RS02505	COG3347	Dehydrogenase
TA_RS02530	COG0528	UMP kinase activity
TA_RS02535	COG1058	Belongs to the CinA family
TA_RS02535	COG1546	Belongs to the CinA family
TA_RS02560	COG0315	cyclic pyranopterin monophosphate synthase activity
TA_RS02565	COG0521	Mo-molybdopterin cofactor biosynthetic process
TA_RS02600	COG0028	Belongs to the TPP enzyme family
TA_RS02630	COG0301	tRNA thio-modification
TA_RS02630	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
TA_RS02635	COG3253	May function as heme-dependent peroxidase
TA_RS02640	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
TA_RS02665	COG0095	Lipoate-protein ligase
TA_RS02670	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
TA_RS02690	COG0017	Asparaginyl-tRNA synthetase
TA_RS02700	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
TA_RS02705	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
TA_RS02740	COG0083	homoserine kinase activity
TA_RS02745	COG0626	cystathionine gamma-synthase activity
TA_RS02775	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
TA_RS02780	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
TA_RS02790	COG1139	Iron-sulfur cluster binding protein
TA_RS02800	COG0247	lactate metabolic process
TA_RS02800	COG2181	nitrate reductase activity
TA_RS02805	COG0277	FAD linked oxidase domain protein
TA_RS02815	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
TA_RS02825	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
TA_RS02850	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TA_RS02850	COG0072	phenylalanine-tRNA ligase activity
TA_RS02890	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
TA_RS02905	COG1994	Peptidase M50
TA_RS02930	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
TA_RS02940	COG1660	Displays ATPase and GTPase activities
TA_RS02945	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
TA_RS02950	COG0181	hydroxymethylbilane synthase activity
TA_RS02960	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
TA_RS02970	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
TA_RS02975	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
TA_RS02980	COG0586	Pfam SNARE associated Golgi protein
TA_RS03000	COG0183	Belongs to the thiolase family
TA_RS03030	COG1201	RNA secondary structure unwinding
TA_RS03085	COG0717	Belongs to the dCTP deaminase family
TA_RS03090	COG1607	acyl-coa hydrolase
TA_RS03110	COG1012	belongs to the aldehyde dehydrogenase family
TA_RS03135	COG1522	sequence-specific DNA binding
TA_RS03140	COG0017	Asparaginyl-tRNA synthetase
TA_RS03145	COG2814	Major facilitator Superfamily
TA_RS03150	COG0517	IMP dehydrogenase activity
TA_RS03170	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
TA_RS03175	COG3958	Transketolase
TA_RS03180	COG3959	Transketolase, thiamine diphosphate binding domain
TA_RS03185	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
TA_RS03190	COG0531	amino acid
TA_RS03200	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
TA_RS03230	COG1144	Oxidoreductase
TA_RS03235	COG0674	pyruvate-flavodoxin oxidoreductase activity
TA_RS03240	COG1013	pyruvate-flavodoxin oxidoreductase activity
TA_RS03250	COG0535	radical SAM domain protein
TA_RS03260	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
TA_RS03270	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
TA_RS03280	COG0285	dihydrofolate synthase activity
TA_RS03330	COG0531	amino acid
TA_RS03335	COG1960	acyl-CoA dehydrogenase activity
TA_RS03345	COG3386	PFAM SMP-30 Gluconolaconase
TA_RS03350	COG0165	Argininosuccinate lyase
TA_RS03355	COG0137	argininosuccinate synthase activity
TA_RS03390	COG2226	methyltransferase
TA_RS03415	COG1228	amidohydrolase
TA_RS03425	COG1506	peptidase
TA_RS03425	COG4946	Tricorn protease homolog
TA_RS03425	COG0823	Involved in the tonB-independent uptake of proteins
TA_RS03440	COG0318	PFAM AMP-dependent synthetase and ligase
TA_RS03445	COG1234	tRNA 3'-trailer cleavage
TA_RS03450	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
TA_RS03455	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
TA_RS03465	COG1028	Short-chain dehydrogenase reductase Sdr
TA_RS03520	COG2271	Major facilitator Superfamily
TA_RS03545	COG3842	ATPase activity
TA_RS03550	COG0395	ABC-type sugar transport system, permease component
TA_RS03560	COG0028	Belongs to the TPP enzyme family
TA_RS03600	COG0275	rRNA processing
TA_RS03680	COG0438	transferase activity, transferring glycosyl groups
TA_RS03720	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
TA_RS03750	COG1335	isochorismatase
TA_RS03765	COG1131	(ABC) transporter
TA_RS03825	COG3254	rhamnose metabolic process
TA_RS03835	COG2814	Major facilitator Superfamily
TA_RS03855	COG0179	Fumarylacetoacetate (FAA) hydrolase
TA_RS03865	COG4948	Mandelate Racemase Muconate Lactonizing
TA_RS03870	COG1312	Catalyzes the dehydration of D-mannonate
TA_RS03875	COG1028	Short-chain dehydrogenase reductase Sdr
TA_RS03885	COG4948	Mandelate Racemase Muconate Lactonizing
TA_RS03895	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
TA_RS03895	COG1796	DNA polymerase
TA_RS03905	COG0463	Glycosyl transferase, family 2
TA_RS03925	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
TA_RS03930	COG0436	Aminotransferase
TA_RS03965	COG1013	pyruvate-flavodoxin oxidoreductase activity
TA_RS03970	COG0674	pyruvate-flavodoxin oxidoreductase activity
TA_RS03970	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
TA_RS03975	COG1056	cytidyltransferase-related domain
TA_RS03975	COG1051	belongs to the nudix hydrolase family
TA_RS03980	COG2271	Major facilitator Superfamily
TA_RS03985	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
TA_RS03990	COG0495	leucyl-tRNA aminoacylation
TA_RS03995	COG1945	arginine decarboxylase activity
TA_RS04000	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
TA_RS04005	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
TA_RS04010	COG0673	inositol 2-dehydrogenase activity
TA_RS04050	COG1196	nuclear chromosome segregation
TA_RS04065	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
TA_RS04070	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
TA_RS04075	COG0505	Belongs to the CarA family
TA_RS04080	COG2814	Major facilitator Superfamily
TA_RS04100	COG1489	DNA binding
TA_RS04130	COG2226	methyltransferase
TA_RS04150	COG0135	phosphoribosylanthranilate isomerase activity
TA_RS04170	COG1012	belongs to the aldehyde dehydrogenase family
TA_RS04185	COG3620	sequence-specific DNA binding
TA_RS04185	COG0617	tRNA 3'-terminal CCA addition
TA_RS04185	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
TA_RS04190	COG0312	modulator of DNA gyrase
TA_RS04200	COG0308	aminopeptidase N
TA_RS04205	COG0028	Belongs to the TPP enzyme family
TA_RS04210	COG1214	PFAM Peptidase M22, glycoprotease
TA_RS04210	COG0456	acetyltransferase
TA_RS04220	COG0372	Belongs to the citrate synthase family
TA_RS04240	COG2062	phosphohistidine phosphatase, SixA
TA_RS04250	COG1940	carbohydrate kinase activity
TA_RS04295	COG2267	carboxylic ester hydrolase activity
TA_RS04320	COG4581	dead DEAH box helicase
TA_RS04330	COG0446	pyridine nucleotide-disulphide oxidoreductase
TA_RS04335	COG1201	RNA secondary structure unwinding
TA_RS04345	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
TA_RS04365	COG0546	phosphoglycolate phosphatase activity
TA_RS04385	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
TA_RS04400	COG2226	methyltransferase
TA_RS04410	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
TA_RS04425	COG1131	(ABC) transporter
TA_RS04430	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
TA_RS04445	COG0501	Belongs to the peptidase M48B family
TA_RS04465	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
TA_RS04470	COG3118	belongs to the thioredoxin family
TA_RS04500	COG1321	iron dependent repressor
TA_RS04525	COG0833	amino acid
TA_RS04535	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
TA_RS04545	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
TA_RS04550	COG4948	Mandelate Racemase Muconate Lactonizing
TA_RS04570	COG0574	Belongs to the PEP-utilizing enzyme family
TA_RS04570	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
TA_RS04575	COG2267	carboxylic ester hydrolase activity
TA_RS04585	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
TA_RS04595	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
TA_RS04635	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
TA_RS04640	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
TA_RS04665	COG4962	Type ii secretion system protein e
TA_RS04670	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
TA_RS04675	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TA_RS04680	COG0417	DNA replication proofreading
TA_RS04690	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
TA_RS04705	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
TA_RS04715	COG0077	Prephenate dehydratase
TA_RS04715	COG1605	Chorismate mutase
TA_RS04745	COG0714	Associated with various cellular activities
TA_RS04775	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
TA_RS04800	COG0101	tRNA pseudouridine synthase activity
TA_RS04805	COG2271	Major facilitator Superfamily
TA_RS04825	COG0442	prolyl-tRNA aminoacylation
TA_RS04860	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
TA_RS04860	COG0731	radical SAM domain protein
TA_RS04865	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
TA_RS04875	COG0518	GMP synthase (glutamine-hydrolyzing) activity
TA_RS04875	COG0519	Catalyzes the synthesis of GMP from XMP
TA_RS04885	COG0017	Asparaginyl-tRNA synthetase
TA_RS04890	COG1250	3-hydroxyacyl-CoA dehydrogenase
TA_RS04910	COG0720	synthase
TA_RS04915	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
TA_RS04920	COG0039	L-malate dehydrogenase activity
TA_RS04930	COG0450	alkyl hydroperoxide reductase
TA_RS04935	COG0113	porphobilinogen synthase activity
TA_RS04955	COG1007	ATP synthesis coupled electron transport
TA_RS04960	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TA_RS04965	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
TA_RS04970	COG0713	ATP synthesis coupled electron transport
TA_RS04980	COG0839	Belongs to the complex I subunit 6 family
TA_RS04985	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TA_RS04990	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
TA_RS04995	COG0649	NAD binding
TA_RS05000	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TA_RS05005	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TA_RS05010	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TA_RS05020	COG0252	asparaginase activity
TA_RS05030	COG1960	acyl-CoA dehydrogenase activity
TA_RS05055	COG0646	methionine synthase
TA_RS05055	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
TA_RS05060	COG0459	protein refolding
TA_RS05065	COG1522	sequence-specific DNA binding
TA_RS05080	COG0492	ferredoxin-NADP+ reductase activity
TA_RS05085	COG0730	response to heat
TA_RS05120	COG1331	Highly conserved protein containing a thioredoxin domain
TA_RS05135	COG0405	Gamma-glutamyltransferase
TA_RS05140	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
TA_RS05150	COG1867	N(2),N(2)-dimethylguanosine tRNA methyltransferase
TA_RS05175	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
TA_RS05195	COG1832	CoA-binding protein
TA_RS05245	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
TA_RS05245	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
TA_RS05285	COG0303	'Molybdopterin
TA_RS05295	COG2814	Major facilitator Superfamily
TA_RS05315	COG1137	ATPase activity
TA_RS05340	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
TA_RS05345	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
TA_RS05350	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
TA_RS05410	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
TA_RS05415	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TA_RS05450	COG1335	isochorismatase
TA_RS05455	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
TA_RS05460	COG0187	DNA topoisomerase II activity
TA_RS05475	COG0010	Belongs to the arginase family
TA_RS05495	COG0477	Major facilitator Superfamily
TA_RS05520	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
TA_RS05540	COG2095	MarC family integral membrane protein
TA_RS05565	COG0126	phosphoglycerate kinase activity
TA_RS05575	COG0552	protein localization to endoplasmic reticulum
TA_RS05575	COG0457	Tetratricopeptide repeat
TA_RS05580	COG0436	Aminotransferase
TA_RS05595	COG0470	DNA polymerase III
TA_RS05595	COG1067	ATP-dependent peptidase activity
TA_RS05605	COG1030	water channel activity
TA_RS05610	COG1881	PFAM PEBP family protein
TA_RS05620	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
TA_RS05630	COG0484	heat shock protein binding
TA_RS05635	COG1185	polyribonucleotide nucleotidyltransferase activity
TA_RS05710	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
TA_RS05720	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
TA_RS05730	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
TA_RS05750	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
TA_RS05755	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
TA_RS05760	COG0105	UTP biosynthetic process
TA_RS05815	COG0579	oxidoreductase
TA_RS05895	COG1469	GTP cyclohydrolase I activity
TA_RS05915	COG2414	aldehyde ferredoxin oxidoreductase
TA_RS05920	COG2217	Heavy metal translocating P-type atpase
TA_RS05935	COG0215	cysteine-tRNA ligase activity
TA_RS05940	COG1793	dna ligase
TA_RS05965	COG0179	Fumarylacetoacetate (FAA) hydrolase
TA_RS05970	COG1234	tRNA 3'-trailer cleavage
TA_RS05985	COG0371	Dehydrogenase
TA_RS06005	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TA_RS06015	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
TA_RS06020	COG2814	Major facilitator Superfamily
TA_RS06025	COG1846	Transcriptional regulator
TA_RS06045	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
TA_RS06075	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
TA_RS06090	COG1116	anion transmembrane transporter activity
TA_RS06110	COG0673	inositol 2-dehydrogenase activity
TA_RS06150	COG0156	8-amino-7-oxononanoate synthase activity
TA_RS06155	COG0052	Belongs to the universal ribosomal protein uS2 family
TA_RS06170	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
TA_RS06185	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
TA_RS06200	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
TA_RS06205	COG1797	cobyrinic acid a,c-diamide synthase activity
TA_RS06245	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
TA_RS06280	COG1435	thymidine kinase activity
TA_RS06320	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
TA_RS06330	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
TA_RS06335	COG0805	protein transport
TA_RS06345	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
TA_RS06415	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
TA_RS06425	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
TA_RS06460	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
TA_RS06480	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
TA_RS06485	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
TA_RS06490	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
TA_RS06505	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
TA_RS06530	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
TA_RS06535	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
TA_RS06545	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
TA_RS06550	COG0089	rRNA binding
TA_RS06560	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
TA_RS06565	COG1090	epimerase
TA_RS06590	COG0459	protein refolding
TA_RS06595	COG0352	thiamine-phosphate diphosphorylase activity
TA_RS06600	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
TA_RS06605	COG0531	amino acid
TA_RS06610	COG4608	Belongs to the ABC transporter superfamily
TA_RS06615	COG0351	phosphomethylpyrimidine kinase
TA_RS06615	COG0352	thiamine-phosphate diphosphorylase activity
TA_RS06625	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TA_RS06625	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TA_RS06645	COG0477	Major facilitator Superfamily
TA_RS06670	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
TA_RS06705	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
TA_RS06755	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
TA_RS06760	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
TA_RS06765	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
TA_RS06780	COG0142	geranyltranstransferase activity
TA_RS06785	COG4974	Belongs to the 'phage' integrase family
TA_RS06790	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
TA_RS06795	COG1063	alcohol dehydrogenase
TA_RS06810	COG0047	phosphoribosylformylglycinamidine synthase activity
TA_RS06815	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
TA_RS06820	COG2264	protein methyltransferase activity
TA_RS06835	COG2723	6-phospho-beta-galactosidase activity
TA_RS06845	COG0444	Belongs to the ABC transporter superfamily
TA_RS06870	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
TA_RS06880	COG0045	succinate-CoA ligase (ADP-forming) activity
TA_RS06925	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
TA_RS06955	COG0588	phosphoglycerate mutase activity
TA_RS07020	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
TA_RS07030	COG0602	queuosine metabolic process
TA_RS07045	COG0519	Catalyzes the synthesis of GMP from XMP
TA_RS07045	COG0518	GMP synthase (glutamine-hydrolyzing) activity
TA_RS07065	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
TA_RS07070	COG0509	glycine decarboxylation via glycine cleavage system
TA_RS07075	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
TA_RS07130	COG2814	Major facilitator Superfamily
TA_RS07190	COG2271	Major facilitator Superfamily
TA_RS07200	COG2721	sulfolactate sulfo-lyase activity
TA_RS07270	COG2814	Major facilitator Superfamily
TA_RS07275	COG0477	Major facilitator Superfamily
TA_RS07305	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
TA_RS07350	COG2222	sugar isomerase
TA_RS07390	COG1980	fructose-bisphosphate aldolase activity
TA_RS07420	COG2045	Belongs to the ComB family
TA_RS07425	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
TA_RS07430	COG2096	Adenosyltransferase
TA_RS07445	COG0022	dehydrogenase e1 component
TA_RS07450	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
TA_RS07455	COG0024	Methionine aminopeptidase
TA_RS07475	COG0640	Transcriptional regulator
TA_RS07480	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
TA_RS07510	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
TA_RS07515	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
TA_RS07515	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
TA_RS07520	COG0667	Aldo Keto reductase
TA_RS07535	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
TA_RS07540	COG0183	Belongs to the thiolase family
TA_RS07550	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
TA_RS07565	COG1597	lipid kinase activity
TA_RS07595	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
TA_RS07595	COG0731	radical SAM domain protein
TA_RS07600	COG1252	NADH dehydrogenase
TA_RS07615	COG0697	spore germination
TA_RS07625	COG1216	Glycosyl transferase, family 2
TA_RS07630	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
TA_RS07645	COG3404	Formiminotransferase-cyclodeaminase
TA_RS07650	COG2759	Belongs to the formate--tetrahydrofolate ligase family
TA_RS07655	COG0489	protein tyrosine kinase activity
TA_RS07665	COG0314	molybdopterin synthase activity
TA_RS07695	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
TA_RS07700	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
TA_RS07720	COG0793	Belongs to the peptidase S41A family
TA_RS07720	COG4946	Tricorn protease homolog
TA_RS07730	COG1129	ABC transporter
TA_RS07735	COG0343	queuine tRNA-ribosyltransferase activity
TA_RS07755	COG0174	glutamine synthetase
TA_RS07760	COG1674	ftsk spoiiie
TA_RS07765	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
TA_RS07805	COG0708	Exodeoxyribonuclease III
TA_RS07815	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TA_RS07820	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
TA_RS07875	COG1215	transferase activity, transferring glycosyl groups
TA_RS07945	COG1324	tolerance protein