locus-tag	class	description
TVG_RS00005	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
TVG_RS00010	COG3383	formate dehydrogenase (NAD+) activity
TVG_RS00025	COG2271	Major facilitator Superfamily
TVG_RS00060	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
TVG_RS00065	COG1199	ATP-dependent helicase activity
TVG_RS00075	COG1812	S-adenosylmethionine synthetase (AdoMet synthetase)
TVG_RS00080	COG0138	bifunctional purine biosynthesis protein purh
TVG_RS00085	COG1024	Enoyl-CoA hydratase
TVG_RS00095	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
TVG_RS00100	COG1254	Belongs to the acylphosphatase family
TVG_RS00110	COG4555	ABC transporter
TVG_RS00120	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
TVG_RS00130	COG0003	Pfam Anion-transporting ATPase
TVG_RS00135	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
TVG_RS00140	COG0284	orotidine-5'-phosphate decarboxylase activity
TVG_RS00165	COG0504	CTP synthase activity
TVG_RS00235	COG0708	Exodeoxyribonuclease III
TVG_RS00240	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
TVG_RS00265	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
TVG_RS00270	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
TVG_RS00275	COG1394	ATPase activity, coupled to movement of substances
TVG_RS00290	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
TVG_RS00295	COG0404	The glycine cleavage system catalyzes the degradation of glycine
TVG_RS00335	COG2095	MarC family integral membrane protein
TVG_RS00340	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
TVG_RS00380	COG1312	Catalyzes the dehydration of D-mannonate
TVG_RS00415	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
TVG_RS00425	COG1271	oxidase subunit
TVG_RS00430	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
TVG_RS00450	COG0314	molybdopterin synthase activity
TVG_RS00460	COG0489	protein tyrosine kinase activity
TVG_RS00465	COG2759	Belongs to the formate--tetrahydrofolate ligase family
TVG_RS00470	COG3404	Formiminotransferase-cyclodeaminase
TVG_RS00485	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
TVG_RS00500	COG2045	Belongs to the ComB family
TVG_RS00505	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
TVG_RS00510	COG2096	Adenosyltransferase
TVG_RS00525	COG0022	dehydrogenase e1 component
TVG_RS00530	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
TVG_RS00535	COG0024	Methionine aminopeptidase
TVG_RS00545	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
TVG_RS00550	COG1518	maintenance of DNA repeat elements
TVG_RS00570	COG1337	RAMP superfamily
TVG_RS00580	COG1353	crispr-associated protein
TVG_RS00645	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TVG_RS00650	COG2814	Major facilitator Superfamily
TVG_RS00660	COG2189	Belongs to the N(4) N(6)-methyltransferase family
TVG_RS00675	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
TVG_RS00675	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
TVG_RS00680	COG0667	Aldo Keto reductase
TVG_RS00690	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
TVG_RS00695	COG0183	Belongs to the thiolase family
TVG_RS00705	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
TVG_RS00735	COG2814	Major facilitator Superfamily
TVG_RS00780	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
TVG_RS00810	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
TVG_RS00830	COG0358	DNA primase activity
TVG_RS00850	COG0776	regulation of translation
TVG_RS00860	COG0049	tRNA binding
TVG_RS00875	COG1131	(ABC) transporter
TVG_RS00885	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TVG_RS00890	COG4948	Mandelate Racemase Muconate Lactonizing
TVG_RS00895	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
TVG_RS00905	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
TVG_RS00915	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
TVG_RS00920	COG0626	cystathionine gamma-synthase activity
TVG_RS00930	COG2271	Major facilitator Superfamily
TVG_RS00945	COG1304	FMN binding
TVG_RS00950	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
TVG_RS00955	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
TVG_RS00975	COG0516	GMP reductase activity
TVG_RS00975	COG0517	IMP dehydrogenase activity
TVG_RS00990	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
TVG_RS00995	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
TVG_RS01020	COG0538	isocitrate dehydrogenase activity
TVG_RS01025	COG1859	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase
TVG_RS01030	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
TVG_RS01035	COG1024	Enoyl-CoA hydratase
TVG_RS01045	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
TVG_RS01080	COG3842	ATPase activity
TVG_RS01130	COG0366	Alpha amylase catalytic
TVG_RS01165	COG0463	Glycosyl transferase, family 2
TVG_RS01170	COG0477	Major facilitator Superfamily
TVG_RS01185	COG0419	ATPase involved in DNA repair
TVG_RS01250	COG0372	Belongs to the citrate synthase family
TVG_RS01265	COG3383	formate dehydrogenase (NAD+) activity
TVG_RS01275	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
TVG_RS01280	COG2814	Major facilitator Superfamily
TVG_RS01285	COG2264	protein methyltransferase activity
TVG_RS01300	COG0537	adenosine 5'-monophosphoramidase activity
TVG_RS01305	COG2271	Major facilitator Superfamily
TVG_RS01335	COG2814	Major facilitator Superfamily
TVG_RS01340	COG0588	phosphoglycerate mutase activity
TVG_RS01365	COG0494	nUDIX hydrolase
TVG_RS01370	COG0142	geranyltranstransferase activity
TVG_RS01375	COG4974	Belongs to the 'phage' integrase family
TVG_RS01380	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
TVG_RS01385	COG0604	alcohol dehydrogenase
TVG_RS01395	COG0047	phosphoribosylformylglycinamidine synthase activity
TVG_RS01400	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
TVG_RS01405	COG2264	protein methyltransferase activity
TVG_RS01415	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
TVG_RS01420	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
TVG_RS01425	COG0045	succinate-CoA ligase (ADP-forming) activity
TVG_RS01470	COG0561	phosphatase activity
TVG_RS01485	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TVG_RS01495	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
TVG_RS01505	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
TVG_RS01510	COG0509	glycine decarboxylation via glycine cleavage system
TVG_RS01515	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
TVG_RS01535	COG0519	Catalyzes the synthesis of GMP from XMP
TVG_RS01535	COG0518	GMP synthase (glutamine-hydrolyzing) activity
TVG_RS01550	COG0602	queuosine metabolic process
TVG_RS01555	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
TVG_RS01560	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
TVG_RS01590	COG0477	Major facilitator Superfamily
TVG_RS01615	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
TVG_RS01650	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
TVG_RS01705	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
TVG_RS01715	COG0089	rRNA binding
TVG_RS01720	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
TVG_RS01725	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
TVG_RS01730	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
TVG_RS01735	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
TVG_RS01740	COG0255	Belongs to the universal ribosomal protein uL29 family
TVG_RS01755	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
TVG_RS01760	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
TVG_RS01775	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
TVG_RS01780	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
TVG_RS01785	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
TVG_RS01805	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
TVG_RS01835	COG1102	Psort location Cytoplasmic, score
TVG_RS01840	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
TVG_RS01850	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
TVG_RS01900	COG2353	YceI-like domain
TVG_RS01915	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
TVG_RS01925	COG0805	protein transport
TVG_RS01930	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
TVG_RS01940	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
TVG_RS01985	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
TVG_RS02000	COG0527	aspartate kinase activity
TVG_RS02000	COG0460	homoserine dehydrogenase
TVG_RS02005	COG1116	anion transmembrane transporter activity
TVG_RS02025	COG0673	inositol 2-dehydrogenase activity
TVG_RS02065	COG1012	belongs to the aldehyde dehydrogenase family
TVG_RS02065	COG1454	alcohol dehydrogenase
TVG_RS02070	COG1012	belongs to the aldehyde dehydrogenase family
TVG_RS02075	COG0156	8-amino-7-oxononanoate synthase activity
TVG_RS02080	COG0052	Belongs to the universal ribosomal protein uS2 family
TVG_RS02095	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
TVG_RS02110	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
TVG_RS02120	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
TVG_RS02125	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
TVG_RS02140	COG1185	polyribonucleotide nucleotidyltransferase activity
TVG_RS02165	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
TVG_RS02175	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
TVG_RS02190	COG0081	regulation of translation
TVG_RS02195	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
TVG_RS02200	COG0693	protein deglycase activity
TVG_RS02240	COG0438	transferase activity, transferring glycosyl groups
TVG_RS02270	COG2271	Major facilitator Superfamily
TVG_RS02275	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
TVG_RS02280	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
TVG_RS02315	COG0037	tRNA processing
TVG_RS02355	COG0105	UTP biosynthetic process
TVG_RS02360	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
TVG_RS02365	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
TVG_RS02370	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
TVG_RS02385	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
TVG_RS02450	COG3634	alkyl hydroperoxide reductase activity
TVG_RS02465	COG0446	pyridine nucleotide-disulphide oxidoreductase
TVG_RS02535	COG0557	exoribonuclease II activity
TVG_RS02540	COG0484	heat shock protein binding
TVG_RS02550	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
TVG_RS02555	COG2211	Major facilitator Superfamily
TVG_RS02560	COG1881	PFAM PEBP family protein
TVG_RS02565	COG1030	water channel activity
TVG_RS02575	COG1067	ATP-dependent peptidase activity
TVG_RS02575	COG0470	DNA polymerase III
TVG_RS02585	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
TVG_RS02610	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
TVG_RS02615	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
TVG_RS02620	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
TVG_RS02635	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
TVG_RS02640	COG1090	epimerase
TVG_RS02655	COG0352	thiamine-phosphate diphosphorylase activity
TVG_RS02680	COG0351	phosphomethylpyrimidine kinase
TVG_RS02690	COG0402	S-adenosylhomocysteine deaminase activity
TVG_RS02700	COG0477	Major facilitator Superfamily
TVG_RS02730	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
TVG_RS02750	COG2095	MarC family integral membrane protein
TVG_RS02775	COG0126	phosphoglycerate kinase activity
TVG_RS02790	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TVG_RS02790	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TVG_RS02820	COG0010	Belongs to the arginase family
TVG_RS02835	COG0187	DNA topoisomerase II activity
TVG_RS02840	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
TVG_RS02845	COG1335	isochorismatase
TVG_RS02860	COG3842	ATPase activity
TVG_RS02870	COG1215	transferase activity, transferring glycosyl groups
TVG_RS02885	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TVG_RS02925	COG0006	proline dipeptidase activity
TVG_RS02945	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
TVG_RS02950	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
TVG_RS02955	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
TVG_RS02970	COG0303	'Molybdopterin
TVG_RS02975	COG0303	'Molybdopterin
TVG_RS02985	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
TVG_RS02995	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
TVG_RS03040	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
TVG_RS03060	COG1032	radical SAM domain protein
TVG_RS03080	COG1058	Belongs to the CinA family
TVG_RS03080	COG1546	Belongs to the CinA family
TVG_RS03110	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
TVG_RS03115	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
TVG_RS03125	COG1139	Iron-sulfur cluster binding protein
TVG_RS03140	COG2181	nitrate reductase activity
TVG_RS03140	COG0247	lactate metabolic process
TVG_RS03145	COG0277	FAD linked oxidase domain protein
TVG_RS03155	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
TVG_RS03165	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
TVG_RS03190	COG0072	phenylalanine-tRNA ligase activity
TVG_RS03230	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
TVG_RS03245	COG1994	Peptidase M50
TVG_RS03260	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
TVG_RS03270	COG0194	GDP metabolic process
TVG_RS03285	COG0151	Belongs to the GarS family
TVG_RS03310	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
TVG_RS03315	COG0540	Belongs to the ATCase OTCase family
TVG_RS03330	COG0181	hydroxymethylbilane synthase activity
TVG_RS03335	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
TVG_RS03340	COG0717	Belongs to the dCTP deaminase family
TVG_RS03345	COG1607	acyl-coa hydrolase
TVG_RS03390	COG1201	RNA secondary structure unwinding
TVG_RS03395	COG0589	response to stress
TVG_RS03410	COG0183	Belongs to the thiolase family
TVG_RS03420	COG0586	Pfam SNARE associated Golgi protein
TVG_RS03430	COG1012	belongs to the aldehyde dehydrogenase family
TVG_RS03455	COG1522	sequence-specific DNA binding
TVG_RS03460	COG0017	Asparaginyl-tRNA synthetase
TVG_RS03470	COG0477	Major facilitator Superfamily
TVG_RS03475	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
TVG_RS03475	COG0617	tRNA 3'-terminal CCA addition
TVG_RS03475	COG0517	IMP dehydrogenase activity
TVG_RS03485	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
TVG_RS03495	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
TVG_RS03500	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
TVG_RS03505	COG3959	Transketolase, thiamine diphosphate binding domain
TVG_RS03510	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
TVG_RS03515	COG1960	acyl-CoA dehydrogenase activity
TVG_RS03520	COG0318	PFAM AMP-dependent synthetase and ligase
TVG_RS03530	COG0393	Putative heavy-metal-binding
TVG_RS03535	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
TVG_RS03610	COG2723	6-phospho-beta-galactosidase activity
TVG_RS03665	COG3385	transposase activity
TVG_RS03680	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
TVG_RS03755	COG1489	DNA binding
TVG_RS03775	COG0531	amino acid
TVG_RS03815	COG1280	lysine exporter protein (LysE YggA)
TVG_RS03825	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
TVG_RS03865	COG4974	Belongs to the 'phage' integrase family
TVG_RS03910	COG4974	Belongs to the 'phage' integrase family
TVG_RS03920	COG0657	acetylesterase activity
TVG_RS03930	COG1940	carbohydrate kinase activity
TVG_RS03940	COG0406	alpha-ribazole phosphatase activity
TVG_RS03945	COG1331	Highly conserved protein containing a thioredoxin domain
TVG_RS03965	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
TVG_RS03975	COG1867	N(2),N(2)-dimethylguanosine tRNA methyltransferase
TVG_RS03990	COG0210	DNA helicase
TVG_RS03995	COG1473	amidohydrolase
TVG_RS04010	COG1832	CoA-binding protein
TVG_RS04090	COG0285	dihydrofolate synthase activity
TVG_RS04100	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
TVG_RS04105	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
TVG_RS04110	COG0495	leucyl-tRNA aminoacylation
TVG_RS04115	COG1945	arginine decarboxylase activity
TVG_RS04145	COG0281	malic enzyme
TVG_RS04160	COG1335	isochorismatase
TVG_RS04165	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
TVG_RS04165	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
TVG_RS04170	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
TVG_RS04175	COG1703	isobutyryl-CoA mutase activity
TVG_RS04185	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
TVG_RS04190	COG3118	belongs to the thioredoxin family
TVG_RS04210	COG1515	deoxyribonuclease V activity
TVG_RS04220	COG2379	hydroxypyruvate reductase
TVG_RS04255	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
TVG_RS04255	COG0301	tRNA thio-modification
TVG_RS04260	COG3253	May function as heme-dependent peroxidase
TVG_RS04265	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
TVG_RS04280	COG2414	aldehyde ferredoxin oxidoreductase
TVG_RS04290	COG0517	IMP dehydrogenase activity
TVG_RS04295	COG0312	modulator of DNA gyrase
TVG_RS04300	COG0312	modulator of DNA gyrase
TVG_RS04305	COG0308	aminopeptidase N
TVG_RS04310	COG2814	Major facilitator Superfamily
TVG_RS04315	COG0505	Belongs to the CarA family
TVG_RS04325	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
TVG_RS04335	COG0019	diaminopimelate decarboxylase activity
TVG_RS04340	COG1196	nuclear chromosome segregation
TVG_RS04355	COG0477	Major facilitator Superfamily
TVG_RS04380	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
TVG_RS04410	COG0446	pyridine nucleotide-disulphide oxidoreductase
TVG_RS04415	COG1201	RNA secondary structure unwinding
TVG_RS04425	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
TVG_RS04445	COG0417	DNA replication proofreading
TVG_RS04455	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
TVG_RS04460	COG1250	3-hydroxyacyl-CoA dehydrogenase
TVG_RS04465	COG1573	uracil-dna glycosylase
TVG_RS04475	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
TVG_RS04500	COG1144	Oxidoreductase
TVG_RS04505	COG0674	pyruvate-flavodoxin oxidoreductase activity
TVG_RS04510	COG1013	pyruvate-flavodoxin oxidoreductase activity
TVG_RS04515	COG2226	methyltransferase
TVG_RS04520	COG0535	radical SAM domain protein
TVG_RS04530	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
TVG_RS04555	COG1056	cytidyltransferase-related domain
TVG_RS04555	COG1051	belongs to the nudix hydrolase family
TVG_RS04560	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
TVG_RS04560	COG0674	pyruvate-flavodoxin oxidoreductase activity
TVG_RS04565	COG1013	pyruvate-flavodoxin oxidoreductase activity
TVG_RS04570	COG0436	Aminotransferase
TVG_RS04580	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
TVG_RS04600	COG0463	Glycosyl transferase, family 2
TVG_RS04610	COG1796	DNA polymerase
TVG_RS04610	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
TVG_RS04635	COG0077	Prephenate dehydratase
TVG_RS04635	COG1605	Chorismate mutase
TVG_RS04785	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
TVG_RS04800	COG1506	peptidase
TVG_RS04800	COG0823	Involved in the tonB-independent uptake of proteins
TVG_RS04800	COG4946	Tricorn protease homolog
TVG_RS04830	COG0405	Gamma-glutamyltransferase
TVG_RS04840	COG4946	Tricorn protease homolog
TVG_RS04840	COG0793	Belongs to the peptidase S41A family
TVG_RS04845	COG4106	trans-aconitate 2-methyltransferase activity
TVG_RS04865	COG1091	dTDP-4-dehydrorhamnose reductase activity
TVG_RS04885	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
TVG_RS04885	COG1215	transferase activity, transferring glycosyl groups
TVG_RS04890	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
TVG_RS04905	COG1804	L-carnitine dehydratase bile acid-inducible protein F
TVG_RS04910	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
TVG_RS04915	COG2267	carboxylic ester hydrolase activity
TVG_RS04925	COG4946	Tricorn protease homolog
TVG_RS04925	COG1506	peptidase
TVG_RS04925	COG0823	Involved in the tonB-independent uptake of proteins
TVG_RS04935	COG1574	metal-dependent hydrolase with the TIM-barrel fold
TVG_RS04940	COG1024	Enoyl-CoA hydratase
TVG_RS04965	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
TVG_RS04980	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
TVG_RS04980	COG1648	precorrin-2 dehydrogenase activity
TVG_RS05005	COG0165	Argininosuccinate lyase
TVG_RS05010	COG3386	PFAM SMP-30 Gluconolaconase
TVG_RS05015	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
TVG_RS05020	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
TVG_RS05025	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
TVG_RS05035	COG1695	Transcriptional regulator
TVG_RS05055	COG1321	iron dependent repressor
TVG_RS05075	COG0546	phosphoglycolate phosphatase activity
TVG_RS05080	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
TVG_RS05085	COG1063	alcohol dehydrogenase
TVG_RS05095	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
TVG_RS05110	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
TVG_RS05140	COG2226	methyltransferase
TVG_RS05145	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
TVG_RS05160	COG1131	(ABC) transporter
TVG_RS05165	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
TVG_RS05190	COG2391	methyltransferase activity
TVG_RS05225	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
TVG_RS05250	COG0574	Belongs to the PEP-utilizing enzyme family
TVG_RS05250	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
TVG_RS05270	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
TVG_RS05275	COG0148	phosphopyruvate hydratase activity
TVG_RS05300	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
TVG_RS05305	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
TVG_RS05310	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
TVG_RS05330	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
TVG_RS05350	COG0017	Asparaginyl-tRNA synthetase
TVG_RS05360	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
TVG_RS05365	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
TVG_RS05380	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
TVG_RS05400	COG0436	Aminotransferase
TVG_RS05405	COG0083	homoserine kinase activity
TVG_RS05410	COG0626	cystathionine gamma-synthase activity
TVG_RS05425	COG0012	GTP binding
TVG_RS05430	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TVG_RS05435	COG0501	Belongs to the peptidase M48B family
TVG_RS05455	COG4962	Type ii secretion system protein e
TVG_RS05460	COG0025	NhaP-type Na H and K H
TVG_RS05465	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
TVG_RS05470	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
TVG_RS05485	COG1012	belongs to the aldehyde dehydrogenase family
TVG_RS05490	COG0134	indole-3-glycerol-phosphate synthase activity
TVG_RS05495	COG0512	Glutamine amidotransferase of anthranilate synthase
TVG_RS05505	COG0135	phosphoribosylanthranilate isomerase activity
TVG_RS05510	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
TVG_RS05530	COG2226	methyltransferase
TVG_RS05565	COG0531	amino acid
TVG_RS05595	COG0004	ammonium transporteR
TVG_RS05640	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
TVG_RS05650	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
TVG_RS05655	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
TVG_RS05670	COG0003	Pfam Anion-transporting ATPase
TVG_RS05675	COG0142	geranyltranstransferase activity
TVG_RS05685	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
TVG_RS05720	COG0714	Associated with various cellular activities
TVG_RS05745	COG0101	tRNA pseudouridine synthase activity
TVG_RS05765	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
TVG_RS05780	COG2271	Major facilitator Superfamily
TVG_RS05795	COG0442	prolyl-tRNA aminoacylation
TVG_RS05825	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
TVG_RS05830	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
TVG_RS05840	COG0519	Catalyzes the synthesis of GMP from XMP
TVG_RS05850	COG0017	Asparaginyl-tRNA synthetase
TVG_RS05855	COG1250	3-hydroxyacyl-CoA dehydrogenase
TVG_RS05875	COG0720	synthase
TVG_RS05880	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
TVG_RS05885	COG0039	L-malate dehydrogenase activity
TVG_RS05895	COG0450	alkyl hydroperoxide reductase
TVG_RS05900	COG0113	porphobilinogen synthase activity
TVG_RS05920	COG1007	ATP synthesis coupled electron transport
TVG_RS05925	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TVG_RS05935	COG0713	ATP synthesis coupled electron transport
TVG_RS05945	COG0839	Belongs to the complex I subunit 6 family
TVG_RS05950	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TVG_RS05960	COG0649	NAD binding
TVG_RS05965	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TVG_RS05970	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TVG_RS05975	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TVG_RS05980	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
TVG_RS05985	COG0252	asparaginase activity
TVG_RS05995	COG1960	acyl-CoA dehydrogenase activity
TVG_RS06010	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
TVG_RS06035	COG0459	protein refolding
TVG_RS06040	COG0492	ferredoxin-NADP+ reductase activity
TVG_RS06060	COG0109	protoheme IX farnesyltransferase activity
TVG_RS06075	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
TVG_RS06080	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
TVG_RS06100	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
TVG_RS06110	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
TVG_RS06125	COG1175	transmembrane transport
TVG_RS06130	COG0395	ABC-type sugar transport system, permease component
TVG_RS06135	COG3842	ATPase activity
TVG_RS06155	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TVG_RS06160	COG1584	GPR1 FUN34 yaaH family protein
TVG_RS06165	COG0656	L-ascorbic acid biosynthetic process
TVG_RS06190	COG0493	'glutamate synthase
TVG_RS06205	COG0477	Major facilitator Superfamily
TVG_RS06210	COG1804	L-carnitine dehydratase bile acid-inducible protein F
TVG_RS06220	COG2814	Major facilitator Superfamily
TVG_RS06240	COG2267	carboxylic ester hydrolase activity
TVG_RS06255	COG0167	dihydroorotate dehydrogenase activity
TVG_RS06260	COG0543	2 iron, 2 sulfur cluster binding
TVG_RS06285	COG1960	acyl-CoA dehydrogenase activity
TVG_RS06315	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
TVG_RS06325	COG0085	RNA polymerase activity
TVG_RS06365	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
TVG_RS06425	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
TVG_RS06510	COG1469	GTP cyclohydrolase I activity
TVG_RS06515	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
TVG_RS06515	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
TVG_RS06520	COG0454	-acetyltransferase
TVG_RS06530	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
TVG_RS06540	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TVG_RS06575	COG0371	Dehydrogenase
TVG_RS06590	COG1234	tRNA 3'-trailer cleavage
TVG_RS06600	COG0179	Fumarylacetoacetate (FAA) hydrolase
TVG_RS06605	COG0045	succinate-CoA ligase (ADP-forming) activity
TVG_RS06605	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
TVG_RS06605	COG1042	CoA-binding domain protein
TVG_RS06625	COG1793	dna ligase
TVG_RS06630	COG0531	amino acid
TVG_RS06635	COG2414	aldehyde ferredoxin oxidoreductase
TVG_RS06655	COG0215	cysteine-tRNA ligase activity
TVG_RS06700	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
TVG_RS06735	COG0494	nUDIX hydrolase
TVG_RS06755	COG0531	amino acid
TVG_RS06775	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TVG_RS06785	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TVG_RS06790	COG1960	acyl-CoA dehydrogenase activity
TVG_RS06810	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
TVG_RS06825	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
TVG_RS06830	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
TVG_RS06835	COG0644	oxidoreductase
TVG_RS06845	COG2086	electron transfer activity
TVG_RS06850	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
TVG_RS06855	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
TVG_RS06860	COG1012	belongs to the aldehyde dehydrogenase family
TVG_RS06865	COG1454	alcohol dehydrogenase
TVG_RS06885	COG0107	imidazoleglycerol-phosphate synthase activity
TVG_RS06890	COG2131	deaminase
TVG_RS06905	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
TVG_RS06910	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
TVG_RS06915	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
TVG_RS06935	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
TVG_RS06940	COG0009	L-threonylcarbamoyladenylate synthase
TVG_RS06945	COG0308	aminopeptidase N
TVG_RS06965	COG0513	Belongs to the DEAD box helicase family
TVG_RS06970	COG0183	Belongs to the thiolase family
TVG_RS06975	COG1960	acyl-CoA dehydrogenase activity
TVG_RS06985	COG1960	acyl-CoA dehydrogenase activity
TVG_RS06995	COG0318	PFAM AMP-dependent synthetase and ligase
TVG_RS07000	COG1250	3-hydroxyacyl-CoA dehydrogenase
TVG_RS07010	COG0517	IMP dehydrogenase activity
TVG_RS07010	COG0617	tRNA 3'-terminal CCA addition
TVG_RS07010	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
TVG_RS07020	COG0667	Aldo Keto reductase
TVG_RS07025	COG3387	PFAM Glycoside hydrolase 15-related
TVG_RS07030	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
TVG_RS07035	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
TVG_RS07045	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
TVG_RS07100	COG4608	Belongs to the ABC transporter superfamily
TVG_RS07115	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TVG_RS07120	COG0601	transmembrane transport
TVG_RS07135	COG1013	pyruvate-flavodoxin oxidoreductase activity
TVG_RS07140	COG0674	pyruvate-flavodoxin oxidoreductase activity
TVG_RS07140	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
TVG_RS07145	COG1027	Aspartate ammonia-lyase
TVG_RS07155	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TVG_RS07175	COG2814	Major facilitator Superfamily
TVG_RS07180	COG1960	acyl-CoA dehydrogenase activity
TVG_RS07185	COG1028	Short-chain dehydrogenase reductase Sdr
TVG_RS07195	COG4948	Mandelate Racemase Muconate Lactonizing
TVG_RS07220	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
TVG_RS07230	COG2986	histidine ammonia-lyase
TVG_RS07245	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
TVG_RS07250	COG1228	amidohydrolase
TVG_RS07255	COG1355	regulation of microtubule-based process
TVG_RS07260	COG2078	PFAM AMMECR1 domain protein
TVG_RS07265	COG1473	amidohydrolase
TVG_RS07270	COG1619	proteins homologs of microcin C7 resistance protein MccF
TVG_RS07290	COG0477	Major facilitator Superfamily
TVG_RS07295	COG1131	(ABC) transporter
TVG_RS07315	COG3189	MarR family transcriptional regulator
TVG_RS07340	COG1012	belongs to the aldehyde dehydrogenase family
TVG_RS07345	COG0517	IMP dehydrogenase activity
TVG_RS07345	COG0516	GMP reductase activity
TVG_RS07355	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
TVG_RS07365	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
TVG_RS07370	COG0585	pseudouridine synthase activity
TVG_RS07385	COG2086	electron transfer activity
TVG_RS07400	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
TVG_RS07435	COG2151	metal-sulfur cluster biosynthetic enzyme
TVG_RS07445	COG2181	nitrate reductase activity
TVG_RS07445	COG0247	lactate metabolic process
TVG_RS07450	COG2271	Major facilitator Superfamily
TVG_RS07455	COG1324	tolerance protein
TVG_RS07480	COG0596	Alpha beta hydrolase
TVG_RS07485	COG1078	dGTPase activity
TVG_RS07625	COG2814	Major facilitator Superfamily
TVG_RS07645	COG1120	ATPase activity
TVG_RS07650	COG1765	OsmC-like protein
TVG_RS07660	COG0446	pyridine nucleotide-disulphide oxidoreductase
TVG_RS07690	COG2222	sugar isomerase
TVG_RS07730	COG1980	fructose-bisphosphate aldolase activity
TVG_RS07760	COG0235	Class ii aldolase
TVG_RS07775	COG0650	Formate hydrogenlyase subunit 4
TVG_RS07785	COG0651	ATP synthesis coupled electron transport
TVG_RS07790	COG0649	NAD binding
TVG_RS07795	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TVG_RS07800	COG1007	ATP synthesis coupled electron transport
TVG_RS07835	COG3385	transposase activity
TVG_RS07910	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
TVG_RS07925	COG1192	Involved in chromosome partitioning
TVG_RS07995	COG0556	nucleotide-excision repair
TVG_RS08005	COG0174	glutamine synthetase
TVG_RS08010	COG1321	iron dependent repressor
TVG_RS08030	COG0343	queuine tRNA-ribosyltransferase activity
TVG_RS08035	COG1129	ABC transporter
TVG_RS08065	COG1072	(Pantothenic acid kinase))
TVG_RS08095	COG0731	radical SAM domain protein
TVG_RS08095	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
TVG_RS08140	COG1215	transferase activity, transferring glycosyl groups
TVG_RS08145	COG4974	Belongs to the 'phage' integrase family
TVG_RS08155	COG1215	transferase activity, transferring glycosyl groups
TVG_RS08160	COG1215	transferase activity, transferring glycosyl groups
TVG_RS08195	COG0444	Belongs to the ABC transporter superfamily
TVG_RS08275	COG3254	rhamnose metabolic process
TVG_RS08370	COG0656	L-ascorbic acid biosynthetic process