locus-tag	class	description
TOCE_RS00010	COG0592	DNA-directed DNA polymerase activity
TOCE_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
TOCE_RS00035	COG0187	DNA topoisomerase II activity
TOCE_RS00040	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
TOCE_RS00050	COG1982	Orn Lys Arg decarboxylase major
TOCE_RS00055	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
TOCE_RS00060	COG3870	Protein conserved in bacteria
TOCE_RS00070	COG0470	DNA polymerase III
TOCE_RS00075	COG1774	PSP1 C-terminal conserved region
TOCE_RS00080	COG2738	Putative neutral zinc metallopeptidase
TOCE_RS00085	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
TOCE_RS00090	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
TOCE_RS00100	COG0352	thiamine-phosphate diphosphorylase activity
TOCE_RS00105	COG0352	thiamine-phosphate diphosphorylase activity
TOCE_RS00105	COG0351	phosphomethylpyrimidine kinase
TOCE_RS00120	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
TOCE_RS00125	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
TOCE_RS00130	COG2002	toxin-antitoxin pair type II binding
TOCE_RS00145	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TOCE_RS00145	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TOCE_RS00150	COG0084	hydrolase, TatD family'
TOCE_RS00160	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
TOCE_RS00165	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
TOCE_RS00180	COG2385	sporulation resulting in formation of a cellular spore
TOCE_RS00185	COG4466	Protein conserved in bacteria
TOCE_RS00215	COG0189	ligase activity
TOCE_RS00215	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
TOCE_RS00220	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
TOCE_RS00225	COG1802	Transcriptional regulator
TOCE_RS00235	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
TOCE_RS00240	COG2088	sporulation resulting in formation of a cellular spore
TOCE_RS00245	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
TOCE_RS00255	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
TOCE_RS00260	COG0193	aminoacyl-tRNA hydrolase activity
TOCE_RS00275	COG3711	transcriptional antiterminator
TOCE_RS00285	COG0246	Mannitol dehydrogenase
TOCE_RS00305	COG1396	sequence-specific DNA binding
TOCE_RS00310	COG3118	belongs to the thioredoxin family
TOCE_RS00315	COG0803	Belongs to the bacterial solute-binding protein 9 family
TOCE_RS00320	COG1121	(ABC) transporter
TOCE_RS00325	COG1108	ABC-type Mn2 Zn2 transport systems permease components
TOCE_RS00340	COG2302	S4 RNA-binding domain
TOCE_RS00385	COG1518	maintenance of DNA repeat elements
TOCE_RS00390	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
TOCE_RS00420	COG3547	Transposase (IS116 IS110 IS902 family)
TOCE_RS00430	COG0583	DNA-binding transcription factor activity
TOCE_RS00435	COG2391	methyltransferase activity
TOCE_RS00455	COG0398	Pfam SNARE associated Golgi protein
TOCE_RS00460	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
TOCE_RS00465	COG4134	Bacterial extracellular solute-binding protein
TOCE_RS00470	COG1178	ABC-type Fe3 transport system permease component
TOCE_RS00480	COG3842	ATPase activity
TOCE_RS00510	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
TOCE_RS00515	COG2002	toxin-antitoxin pair type II binding
TOCE_RS00520	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
TOCE_RS00530	COG2244	polysaccharide biosynthetic process
TOCE_RS00535	COG3956	TIGRFAM MazG family protein
TOCE_RS00545	COG2385	sporulation resulting in formation of a cellular spore
TOCE_RS00565	COG1098	S1 RNA binding domain
TOCE_RS00575	COG0085	RNA polymerase activity
TOCE_RS00585	COG1358	cellular component organization or biogenesis
TOCE_RS00590	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
TOCE_RS00595	COG0049	tRNA binding
TOCE_RS00600	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
TOCE_RS00605	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
TOCE_RS00615	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
TOCE_RS00620	COG0088	Forms part of the polypeptide exit tunnel
TOCE_RS00625	COG0089	rRNA binding
TOCE_RS00630	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
TOCE_RS00635	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
TOCE_RS00640	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
TOCE_RS00645	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
TOCE_RS00650	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
TOCE_RS00665	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
TOCE_RS00670	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
TOCE_RS00680	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
TOCE_RS00685	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
TOCE_RS00690	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
TOCE_RS00695	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
TOCE_RS00700	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
TOCE_RS00705	COG0200	Binds to the 23S rRNA
TOCE_RS00710	COG0201	protein transport
TOCE_RS00715	COG0563	adenylate kinase activity
TOCE_RS00720	COG0024	Methionine aminopeptidase
TOCE_RS00730	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
TOCE_RS00735	COG0257	Belongs to the bacterial ribosomal protein bL36 family
TOCE_RS00740	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
TOCE_RS00745	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
TOCE_RS00755	COG0202	RNA polymerase activity
TOCE_RS00760	COG0203	ribosomal protein L17
TOCE_RS00765	COG1122	ATPase activity
TOCE_RS00770	COG1122	ATPase activity
TOCE_RS00775	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
TOCE_RS00780	COG0101	tRNA pseudouridine synthase activity
TOCE_RS00785	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
TOCE_RS00790	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
TOCE_RS00800	COG0137	argininosuccinate synthase activity
TOCE_RS00810	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
TOCE_RS00820	COG1114	Component of the transport system for branched-chain amino acids
TOCE_RS00825	COG1114	Component of the transport system for branched-chain amino acids
TOCE_RS00835	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
TOCE_RS00840	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
TOCE_RS00885	COG0534	Mate efflux family protein
TOCE_RS00890	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
TOCE_RS00910	COG0709	Synthesizes selenophosphate from selenide and ATP
TOCE_RS00925	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
TOCE_RS00955	COG3069	C4-dicarboxylate transmembrane transporter activity
TOCE_RS00970	COG0640	Transcriptional regulator
TOCE_RS01005	COG2801	Transposase and inactivated derivatives
TOCE_RS01030	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
TOCE_RS01035	COG1238	metal cluster binding
TOCE_RS01045	COG2204	response regulator
TOCE_RS01050	COG5002	protein histidine kinase activity
TOCE_RS01055	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
TOCE_RS01065	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
TOCE_RS01070	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
TOCE_RS01075	COG1966	Carbon starvation protein
TOCE_RS01090	COG3279	Response regulator of the LytR AlgR family
TOCE_RS01120	COG1454	alcohol dehydrogenase
TOCE_RS01125	COG0426	domain, Protein
TOCE_RS01135	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
TOCE_RS01140	COG1773	rubredoxin
TOCE_RS01155	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
TOCE_RS01170	COG0517	IMP dehydrogenase activity
TOCE_RS01170	COG1125	glycine betaine transport
TOCE_RS01175	COG1174	glycine betaine transport
TOCE_RS01225	COG5505	Protein of unknown function (DUF819)
TOCE_RS01250	COG1132	(ABC) transporter
TOCE_RS01280	COG1924	4 iron, 4 sulfur cluster binding
TOCE_RS01285	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
TOCE_RS01290	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
TOCE_RS01295	COG1793	dna ligase
TOCE_RS01300	COG1793	dna ligase
TOCE_RS01300	COG3285	dna ligase
TOCE_RS01310	COG1716	ATPase activity
TOCE_RS01320	COG0768	penicillin binding
TOCE_RS01330	COG1131	(ABC) transporter
TOCE_RS01345	COG1902	pentaerythritol trinitrate reductase activity
TOCE_RS01350	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
TOCE_RS01355	COG0180	Tryptophanyl-tRNA synthetase
TOCE_RS01375	COG3711	transcriptional antiterminator
TOCE_RS01375	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
TOCE_RS01380	COG1447	Phosphotransferase system cellobiose-specific component IIA
TOCE_RS01385	COG1446	asparaginase
TOCE_RS01390	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
TOCE_RS01405	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
TOCE_RS01415	COG0303	'Molybdopterin
TOCE_RS01425	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
TOCE_RS01430	COG0315	cyclic pyranopterin monophosphate synthase activity
TOCE_RS01435	COG0521	Mo-molybdopterin cofactor biosynthetic process
TOCE_RS01480	COG0745	RESPONSE REGULATOR receiver
TOCE_RS01485	COG5002	protein histidine kinase activity
TOCE_RS01495	COG2348	transferase activity, transferring amino-acyl groups
TOCE_RS01500	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
TOCE_RS01510	COG3933	PFAM sigma-54 factor interaction domain-containing protein
TOCE_RS01510	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
TOCE_RS01515	COG1063	alcohol dehydrogenase
TOCE_RS01530	COG3547	Transposase (IS116 IS110 IS902 family)
TOCE_RS01550	COG3716	PTS system mannose fructose sorbose family IID component
TOCE_RS01555	COG2045	Belongs to the ComB family
TOCE_RS01570	COG0310	cobalt ion transport
TOCE_RS01585	COG1122	ATPase activity
TOCE_RS01590	COG1797	cobyrinic acid a,c-diamide synthase activity
TOCE_RS01645	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
TOCE_RS01650	COG0181	hydroxymethylbilane synthase activity
TOCE_RS01655	COG1587	Uroporphyrinogen-III synthase
TOCE_RS01655	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
TOCE_RS01660	COG0113	porphobilinogen synthase activity
TOCE_RS01665	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
TOCE_RS01675	COG0723	plastoquinol--plastocyanin reductase activity
TOCE_RS01675	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
TOCE_RS01680	COG2188	Transcriptional regulator
TOCE_RS01690	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
TOCE_RS01695	COG0697	spore germination
TOCE_RS01730	COG1151	hydroxylamine reductase activity
TOCE_RS01735	COG1959	2 iron, 2 sulfur cluster binding
TOCE_RS01740	COG1737	Transcriptional regulator
TOCE_RS01745	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
TOCE_RS01750	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
TOCE_RS01755	COG1447	Phosphotransferase system cellobiose-specific component IIA
TOCE_RS01765	COG2971	BadF BadG BcrA BcrD
TOCE_RS01770	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
TOCE_RS01775	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
TOCE_RS01780	COG1486	melibiose metabolic process
TOCE_RS01785	COG0456	acetyltransferase
TOCE_RS01785	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
TOCE_RS01790	COG1361	Conserved repeat domain
TOCE_RS01790	COG2911	Protein conserved in bacteria
TOCE_RS01790	COG3266	domain, Protein
TOCE_RS01815	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
TOCE_RS01820	COG0519	Catalyzes the synthesis of GMP from XMP
TOCE_RS01820	COG0518	GMP synthase (glutamine-hydrolyzing) activity
TOCE_RS01825	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
TOCE_RS01830	COG0573	inorganic phosphate transmembrane transporter activity
TOCE_RS01835	COG0581	inorganic phosphate transmembrane transporter activity
TOCE_RS01840	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
TOCE_RS01845	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
TOCE_RS01850	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
TOCE_RS01855	COG1980	fructose-bisphosphate aldolase activity
TOCE_RS01860	COG0733	neurotransmitter:sodium symporter activity
TOCE_RS01865	COG0010	Belongs to the arginase family
TOCE_RS01870	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
TOCE_RS01875	COG0235	Class ii aldolase
TOCE_RS01885	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
TOCE_RS01915	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
TOCE_RS01925	COG1546	Belongs to the CinA family
TOCE_RS01925	COG1058	Belongs to the CinA family
TOCE_RS01935	COG4569	acetaldehyde dehydrogenase (acetylating) activity
TOCE_RS01940	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
TOCE_RS01965	COG2414	aldehyde ferredoxin oxidoreductase
TOCE_RS01975	COG1414	Transcriptional regulator
TOCE_RS01980	COG1606	tRNA processing
TOCE_RS01985	COG1691	(AIR) carboxylase
TOCE_RS01990	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
TOCE_RS01995	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
TOCE_RS02005	COG1725	Transcriptional regulator
TOCE_RS02025	COG1131	(ABC) transporter
TOCE_RS02030	COG1725	Transcriptional regulator
TOCE_RS02035	COG1028	Short-chain dehydrogenase reductase Sdr
TOCE_RS02050	COG1396	sequence-specific DNA binding
TOCE_RS02070	COG0629	single-stranded DNA binding
TOCE_RS02095	COG3547	Transposase (IS116 IS110 IS902 family)
TOCE_RS02210	COG0739	heme binding
TOCE_RS02260	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
TOCE_RS02265	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
TOCE_RS02280	COG1492	cobalamin metabolic process
TOCE_RS02290	COG1013	pyruvate-flavodoxin oxidoreductase activity
TOCE_RS02295	COG0674	pyruvate-flavodoxin oxidoreductase activity
TOCE_RS02300	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
TOCE_RS02300	COG1144	Oxidoreductase
TOCE_RS02305	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
TOCE_RS02325	COG5002	protein histidine kinase activity
TOCE_RS02330	COG0784	Response regulator, receiver
TOCE_RS02335	COG0786	glutamate:sodium symporter activity
TOCE_RS02340	COG0170	dolichyl monophosphate biosynthetic process
TOCE_RS02345	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
TOCE_RS02355	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
TOCE_RS02360	COG1181	Belongs to the D-alanine--D-alanine ligase family
TOCE_RS02370	COG0840	transmembrane signaling receptor activity
TOCE_RS02375	COG0840	transmembrane signaling receptor activity
TOCE_RS02380	COG0835	chemotaxis
TOCE_RS02395	COG2201	protein-glutamate methylesterase activity
TOCE_RS02425	COG0585	pseudouridine synthase activity
TOCE_RS02430	COG1210	Utp--glucose-1-phosphate uridylyltransferase
TOCE_RS02460	COG1404	Belongs to the peptidase S8 family
TOCE_RS02490	COG1216	Glycosyl transferase, family 2
TOCE_RS02495	COG1215	transferase activity, transferring glycosyl groups
TOCE_RS02500	COG0438	transferase activity, transferring glycosyl groups
TOCE_RS02505	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
TOCE_RS02535	COG0489	protein tyrosine kinase activity
TOCE_RS02545	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
TOCE_RS02550	COG0438	transferase activity, transferring glycosyl groups
TOCE_RS02555	COG0297	glycogen (starch) synthase activity
TOCE_RS02560	COG0438	transferase activity, transferring glycosyl groups
TOCE_RS02580	COG0297	glycogen (starch) synthase activity
TOCE_RS02585	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
TOCE_RS02590	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
TOCE_RS02595	COG0232	Belongs to the dGTPase family. Type 2 subfamily
TOCE_RS02605	COG0371	Dehydrogenase
TOCE_RS02615	COG0632	four-way junction helicase activity
TOCE_RS02625	COG2337	Toxic component of a toxin-antitoxin (TA) module
TOCE_RS02645	COG1353	crispr-associated protein
TOCE_RS02655	COG1337	RAMP superfamily
TOCE_RS02700	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
TOCE_RS02715	COG0822	iron-sulfur transferase activity
TOCE_RS02720	COG0383	alpha-mannosidase activity
TOCE_RS02725	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
TOCE_RS02730	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
TOCE_RS02735	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
TOCE_RS02735	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
TOCE_RS02735	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
TOCE_RS02740	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
TOCE_RS02740	COG3711	transcriptional antiterminator
TOCE_RS02760	COG2972	Histidine kinase
TOCE_RS02765	COG2201	protein-glutamate methylesterase activity
TOCE_RS02810	COG4869	propanediol catabolic process
TOCE_RS02840	COG4656	Part of a membrane complex involved in electron transport
TOCE_RS02885	COG0720	synthase
TOCE_RS02895	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
TOCE_RS02900	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
TOCE_RS02900	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
TOCE_RS02905	COG0726	polysaccharide deacetylase
TOCE_RS02910	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
TOCE_RS02915	COG1307	EDD domain protein, DegV family
TOCE_RS02935	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
TOCE_RS02950	COG0310	cobalt ion transport
TOCE_RS02960	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
TOCE_RS02965	COG1122	ATPase activity
TOCE_RS02970	COG1744	ABC transporter substrate-binding protein PnrA-like
TOCE_RS02975	COG3845	ABC transporter
TOCE_RS02980	COG4603	Belongs to the binding-protein-dependent transport system permease family
TOCE_RS02985	COG1079	Belongs to the binding-protein-dependent transport system permease family
TOCE_RS02990	COG2188	Transcriptional regulator
TOCE_RS02995	COG0295	cytidine deaminase activity
TOCE_RS03000	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
TOCE_RS03005	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
TOCE_RS03060	COG0367	asparagine synthase
TOCE_RS03070	COG2226	methyltransferase
TOCE_RS03075	COG0456	acetyltransferase
TOCE_RS03075	COG1214	PFAM Peptidase M22, glycoprotease
TOCE_RS03090	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
TOCE_RS03095	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
TOCE_RS03100	COG0747	negative chemotaxis
TOCE_RS03105	COG0601	transmembrane transport
TOCE_RS03110	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TOCE_RS03120	COG0444	Belongs to the ABC transporter superfamily
TOCE_RS03125	COG4608	Belongs to the ABC transporter superfamily
TOCE_RS03140	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
TOCE_RS03145	COG0287	Prephenate dehydrogenase
TOCE_RS03155	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
TOCE_RS03160	COG0527	aspartate kinase activity
TOCE_RS03170	COG1301	dicarboxylic acid transport
TOCE_RS03175	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
TOCE_RS03210	COG3033	Beta-eliminating lyase
TOCE_RS03215	COG0012	GTP binding
TOCE_RS03220	COG0561	phosphatase activity
TOCE_RS03225	COG1187	pseudouridine synthase activity
TOCE_RS03240	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
TOCE_RS03255	COG1929	Belongs to the glycerate kinase type-1 family
TOCE_RS03260	COG2610	gluconate transmembrane transporter activity
TOCE_RS03265	COG3835	regulator
TOCE_RS03280	COG2721	sulfolactate sulfo-lyase activity
TOCE_RS03295	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
TOCE_RS03300	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
TOCE_RS03305	COG0154	amidase activity
TOCE_RS03310	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
TOCE_RS03315	COG4166	transmembrane transport
TOCE_RS03320	COG0601	transmembrane transport
TOCE_RS03325	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TOCE_RS03330	COG0444	Belongs to the ABC transporter superfamily
TOCE_RS03335	COG4608	Belongs to the ABC transporter superfamily
TOCE_RS03340	COG0037	tRNA processing
TOCE_RS03350	COG1254	Belongs to the acylphosphatase family
TOCE_RS03355	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
TOCE_RS03370	COG0432	Pfam Uncharacterised protein family UPF0047
TOCE_RS03435	COG0525	valine-tRNA ligase activity
TOCE_RS03455	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
TOCE_RS03485	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
TOCE_RS03505	COG4656	Part of a membrane complex involved in electron transport
TOCE_RS03510	COG4658	electron transport chain
TOCE_RS03520	COG4660	Part of a membrane complex involved in electron transport
TOCE_RS03525	COG4657	Part of a membrane complex involved in electron transport
TOCE_RS03530	COG1245	4Fe-4S binding domain
TOCE_RS03530	COG2878	Part of a membrane complex involved in electron transport
TOCE_RS03540	COG5012	cobalamin binding
TOCE_RS03545	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
TOCE_RS03560	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
TOCE_RS03565	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
TOCE_RS03570	COG0626	cystathionine gamma-synthase activity
TOCE_RS03585	COG0785	Cytochrome C biogenesis protein
TOCE_RS03590	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
TOCE_RS03615	COG2217	Heavy metal translocating P-type atpase
TOCE_RS03630	COG3546	catalase activity
TOCE_RS03640	COG2814	Major facilitator Superfamily
TOCE_RS03645	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
TOCE_RS03650	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
TOCE_RS03655	COG1268	BioY protein
TOCE_RS03660	COG2608	mercury ion transmembrane transporter activity
TOCE_RS03680	COG0424	maF-like protein
TOCE_RS03685	COG2003	Belongs to the UPF0758 family
TOCE_RS03690	COG1077	Cell shape determining protein MreB Mrl
TOCE_RS03705	COG0768	penicillin binding
TOCE_RS03710	COG0850	regulation of cytokinetic process
TOCE_RS03715	COG2894	cell division
TOCE_RS03720	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
TOCE_RS03725	COG0772	Belongs to the SEDS family
TOCE_RS03750	COG1530	ribonuclease E activity
TOCE_RS03780	COG2959	enzyme of heme biosynthesis
TOCE_RS03805	COG0261	This protein binds to 23S rRNA in the presence of protein L20
TOCE_RS03810	COG2868	ribosomal protein
TOCE_RS03825	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
TOCE_RS03835	COG1713	HD superfamily hydrolase involved in NAD metabolism
TOCE_RS03840	COG1316	TRANSCRIPTIONal
TOCE_RS03845	COG0799	negative regulation of ribosome biogenesis
TOCE_RS03850	COG0495	leucyl-tRNA aminoacylation
TOCE_RS03855	COG1596	polysaccharide export
TOCE_RS03855	COG1555	photosystem II stabilization
TOCE_RS03875	COG0534	Mate efflux family protein
TOCE_RS03880	COG2116	formate transmembrane transporter activity
TOCE_RS03890	COG3584	3D domain protein
TOCE_RS03890	COG3583	domain protein
TOCE_RS03895	COG1686	Belongs to the peptidase S11 family
TOCE_RS03905	COG2323	membrane
TOCE_RS03920	COG0243	molybdopterin cofactor binding
TOCE_RS03925	COG3383	formate dehydrogenase (NAD+) activity
TOCE_RS03945	COG5012	cobalamin binding
TOCE_RS03960	COG5012	cobalamin binding
TOCE_RS03965	COG2188	Transcriptional regulator
TOCE_RS03990	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
TOCE_RS03995	COG1151	hydroxylamine reductase activity
TOCE_RS04005	COG2759	Belongs to the formate--tetrahydrofolate ligase family
TOCE_RS04015	COG3404	Formiminotransferase-cyclodeaminase
TOCE_RS04020	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
TOCE_RS04035	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
TOCE_RS04095	COG1205	dead DEAH box helicase
TOCE_RS04095	COG1111	helicase
TOCE_RS04100	COG3359	exonuclease
TOCE_RS04105	COG0423	glycine-tRNA ligase activity
TOCE_RS04135	COG3290	protein histidine kinase activity
TOCE_RS04135	COG3829	transcription factor binding
TOCE_RS04140	COG0280	phosphate acetyltransferase
TOCE_RS04150	COG3426	butyrate kinase activity
TOCE_RS04195	COG2309	aminopeptidase activity
TOCE_RS04205	COG0658	competence protein
TOCE_RS04205	COG2333	competence protein COMEC
TOCE_RS04215	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
TOCE_RS04220	COG2222	sugar isomerase
TOCE_RS04225	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
TOCE_RS04245	COG0812	UDP-N-acetylmuramate dehydrogenase activity
TOCE_RS04255	COG0123	including yeast histone deacetylase and acetoin utilization protein
TOCE_RS04270	COG2239	Acts as a magnesium transporter
TOCE_RS04275	COG2239	Acts as a magnesium transporter
TOCE_RS04285	COG3679	Belongs to the UPF0342 family
TOCE_RS04295	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
TOCE_RS04300	COG1660	Displays ATPase and GTPase activities
TOCE_RS04305	COG0391	Required for morphogenesis under gluconeogenic growth conditions
TOCE_RS04310	COG1481	regulation of sporulation
TOCE_RS04315	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
TOCE_RS04320	COG4109	DRTGG domain
TOCE_RS04335	COG0205	6-phosphofructokinase activity
TOCE_RS04350	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
TOCE_RS04355	COG1595	DNA-templated transcription, initiation
TOCE_RS04365	COG1131	(ABC) transporter
TOCE_RS04380	COG2715	membrane protein required for spore maturation
TOCE_RS04385	COG0700	Nucleoside recognition
TOCE_RS04390	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
TOCE_RS04400	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
TOCE_RS04400	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
TOCE_RS04430	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
TOCE_RS04460	COG0658	competence protein
TOCE_RS04460	COG2333	competence protein COMEC
TOCE_RS04475	COG0268	Binds directly to 16S ribosomal RNA
TOCE_RS04485	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
TOCE_RS04500	COG0481	GTPase activity
TOCE_RS04505	COG0635	Involved in the biosynthesis of porphyrin-containing compound
TOCE_RS04510	COG0564	pseudouridine synthase activity
TOCE_RS04515	COG1420	regulation of RNA biosynthetic process
TOCE_RS04520	COG0459	protein refolding
TOCE_RS04530	COG0443	Heat shock 70 kDa protein
TOCE_RS04535	COG0484	heat shock protein binding
TOCE_RS04540	COG2264	protein methyltransferase activity
TOCE_RS04545	COG1385	rRNA (uridine-N3-)-methyltransferase activity
TOCE_RS04550	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TOCE_RS04555	COG0537	adenosine 5'-monophosphoramidase activity
TOCE_RS04580	COG1702	phosphate starvation-inducible protein PhoH
TOCE_RS04585	COG1480	7TM receptor with intracellular HD hydrolase
TOCE_RS04595	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
TOCE_RS04600	COG1470	cell adhesion involved in biofilm formation
TOCE_RS04605	COG1381	Involved in DNA repair and RecF pathway recombination
TOCE_RS04615	COG0517	IMP dehydrogenase activity
TOCE_RS04620	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
TOCE_RS04625	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
TOCE_RS04625	COG0574	Belongs to the PEP-utilizing enzyme family
TOCE_RS04635	COG0232	Belongs to the dGTPase family. Type 2 subfamily
TOCE_RS04640	COG0358	DNA primase activity
TOCE_RS04645	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
TOCE_RS04650	COG2384	SAM-dependent methyltransferase
TOCE_RS04655	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
TOCE_RS04660	COG0328	RNA-DNA hybrid ribonuclease activity
TOCE_RS04685	COG0612	Peptidase, M16
TOCE_RS04690	COG0612	Peptidase, M16
TOCE_RS04695	COG2001	Belongs to the MraZ family
TOCE_RS04700	COG0275	rRNA processing
TOCE_RS04705	COG3116	cell division
TOCE_RS04710	COG0768	penicillin binding
TOCE_RS04720	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
TOCE_RS04725	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
TOCE_RS04730	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
TOCE_RS04735	COG0772	Belongs to the SEDS family
TOCE_RS04740	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
TOCE_RS04745	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
TOCE_RS04750	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
TOCE_RS04755	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
TOCE_RS04765	COG3856	small basic protein
TOCE_RS04775	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
TOCE_RS04785	COG1191	sigma factor activity
TOCE_RS04790	COG1191	sigma factor activity
TOCE_RS04800	COG1873	PFAM PRC-barrel domain
TOCE_RS04810	COG1496	oxidoreductase activity
TOCE_RS04815	COG0745	RESPONSE REGULATOR receiver
TOCE_RS04825	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
TOCE_RS04830	COG0704	Plays a role in the regulation of phosphate uptake
TOCE_RS04870	COG1160	GTP binding
TOCE_RS04875	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
TOCE_RS04880	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
TOCE_RS04885	COG0500	methyltransferase
TOCE_RS04895	COG4974	Belongs to the 'phage' integrase family
TOCE_RS05000	COG0534	Mate efflux family protein
TOCE_RS05010	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
TOCE_RS05015	COG1799	cell septum assembly
TOCE_RS05025	COG3599	regulation of cell shape
TOCE_RS05035	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
TOCE_RS05045	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
TOCE_RS05050	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
TOCE_RS05055	COG0564	pseudouridine synthase activity
TOCE_RS05060	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
TOCE_RS05070	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
TOCE_RS05075	COG0436	Aminotransferase
TOCE_RS05080	COG1561	YicC-like family, N-terminal region
TOCE_RS05085	COG2052	Domain of unknown function (DUF370)
TOCE_RS05090	COG0194	GDP metabolic process
TOCE_RS05095	COG1758	RNA polymerase activity
TOCE_RS05100	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
TOCE_RS05105	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
TOCE_RS05110	COG0242	peptide deformylase activity
TOCE_RS05115	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
TOCE_RS05125	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
TOCE_RS05125	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
TOCE_RS05130	COG0820	rRNA (adenine-C2-)-methyltransferase activity
TOCE_RS05135	COG0631	protein serine/threonine phosphatase activity
TOCE_RS05140	COG2815	serine threonine protein kinase
TOCE_RS05140	COG0515	serine threonine protein kinase
TOCE_RS05145	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
TOCE_RS05155	COG0227	Belongs to the bacterial ribosomal protein bL28 family
TOCE_RS05160	COG1302	Protein conserved in bacteria
TOCE_RS05165	COG1461	Dihydroxyacetone kinase
TOCE_RS05180	COG0742	ribosomal rna small subunit methyltransferase
TOCE_RS05195	COG3314	Sporulation integral membrane protein YlbJ
TOCE_RS05200	COG1752	Esterase of the alpha-beta hydrolase superfamily
TOCE_RS05205	COG3480	Lon protease (S16) C-terminal proteolytic domain
TOCE_RS05210	COG1323	Belongs to the UPF0348 family
TOCE_RS05215	COG0280	phosphate acetyltransferase
TOCE_RS05230	COG0333	Belongs to the bacterial ribosomal protein bL32 family
TOCE_RS05240	COG0416	fatty acid biosynthetic process
TOCE_RS05245	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
TOCE_RS05250	COG1307	EDD domain protein, DegV family
TOCE_RS05255	COG2070	2-Nitropropane dioxygenase
TOCE_RS05260	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
TOCE_RS05265	COG1028	Short-chain dehydrogenase reductase Sdr
TOCE_RS05270	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
TOCE_RS05275	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
TOCE_RS05280	COG0571	ribonuclease III activity
TOCE_RS05285	COG2359	stage V sporulation protein S
TOCE_RS05295	COG0552	protein localization to endoplasmic reticulum
TOCE_RS05305	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
TOCE_RS05310	COG0228	four-way junction DNA binding
TOCE_RS05320	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
TOCE_RS05325	COG0336	Belongs to the RNA methyltransferase TrmD family
TOCE_RS05335	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
TOCE_RS05340	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
TOCE_RS05345	COG0792	nuclease activity
TOCE_RS05360	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
TOCE_RS05365	COG0534	Mate efflux family protein
TOCE_RS05370	COG5012	cobalamin binding
TOCE_RS05390	COG0606	chelatase, subunit chli
TOCE_RS05395	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
TOCE_RS05400	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
TOCE_RS05400	COG0758	DNA mediated transformation
TOCE_RS05405	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
TOCE_RS05410	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
TOCE_RS05415	COG4974	Belongs to the 'phage' integrase family
TOCE_RS05420	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
TOCE_RS05425	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
TOCE_RS05430	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
TOCE_RS05440	COG1815	bacterial-type flagellum-dependent cell motility
TOCE_RS05450	COG1677	Flagellar hook-basal body complex protein FliE
TOCE_RS05455	COG1766	The M ring may be actively involved in energy transduction
TOCE_RS05460	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
TOCE_RS05470	COG1157	protein secretion by the type III secretion system
TOCE_RS05525	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
TOCE_RS05530	COG1776	CheC inhibitor of MCP methylation
TOCE_RS05530	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
TOCE_RS05535	COG2201	protein-glutamate methylesterase activity
TOCE_RS05545	COG1338	Plays a role in the flagellum-specific transport system
TOCE_RS05550	COG1987	bacterial-type flagellum assembly
TOCE_RS05555	COG1684	flagellar biosynthetic protein fliR
TOCE_RS05560	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
TOCE_RS05565	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
TOCE_RS05570	COG1419	protein localization to endoplasmic reticulum
TOCE_RS05585	COG2198	Histidine kinase
TOCE_RS05585	COG0643	Histidine kinase
TOCE_RS05590	COG0835	chemotaxis
TOCE_RS05595	COG1776	CheC inhibitor of MCP methylation
TOCE_RS05600	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
TOCE_RS05605	COG1191	sigma factor activity
TOCE_RS05625	COG1959	2 iron, 2 sulfur cluster binding
TOCE_RS05635	COG0822	iron-sulfur transferase activity
TOCE_RS05640	COG0482	sulfurtransferase activity
TOCE_RS05650	COG0628	permease
TOCE_RS05660	COG0019	diaminopimelate decarboxylase activity
TOCE_RS05665	COG1994	Peptidase M50
TOCE_RS05670	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
TOCE_RS05685	COG3874	Sporulation protein YtfJ
TOCE_RS05695	COG1686	Belongs to the peptidase S11 family
TOCE_RS05700	COG0445	tRNA wobble uridine modification
TOCE_RS05700	COG0445	tRNA wobble uridine modification
TOCE_RS05705	COG0543	2 iron, 2 sulfur cluster binding
TOCE_RS05710	COG0445	tRNA wobble uridine modification
TOCE_RS05710	COG0445	tRNA wobble uridine modification
TOCE_RS05715	COG1187	pseudouridine synthase activity
TOCE_RS05720	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
TOCE_RS05725	COG0010	Belongs to the arginase family
TOCE_RS05730	COG1120	ATPase activity
TOCE_RS05740	COG2081	HI0933 family
TOCE_RS05745	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
TOCE_RS05755	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
TOCE_RS05755	COG0539	negative regulation of cytoplasmic translation
TOCE_RS05765	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
TOCE_RS05770	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
TOCE_RS05810	COG1363	Peptidase, m42
TOCE_RS05835	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
TOCE_RS05890	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
TOCE_RS05895	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
TOCE_RS05910	COG0464	growth
TOCE_RS05915	COG1923	regulation of RNA biosynthetic process
TOCE_RS05920	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
TOCE_RS05925	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
TOCE_RS05930	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
TOCE_RS05935	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TOCE_RS05940	COG1573	uracil-dna glycosylase
TOCE_RS05945	COG2720	vancomycin resistance protein
TOCE_RS05955	COG4770	biotin carboxylase activity
TOCE_RS05965	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
TOCE_RS05970	COG0346	lactoylglutathione lyase activity
TOCE_RS05975	COG1703	isobutyryl-CoA mutase activity
TOCE_RS05980	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
TOCE_RS05980	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
TOCE_RS05985	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
TOCE_RS05985	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
TOCE_RS06000	COG1013	pyruvate-flavodoxin oxidoreductase activity
TOCE_RS06005	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
TOCE_RS06005	COG0674	pyruvate-flavodoxin oxidoreductase activity
TOCE_RS06015	COG0587	DNA-directed DNA polymerase activity
TOCE_RS06020	COG2359	stage V sporulation protein S
TOCE_RS06025	COG1692	metallophosphoesterase
TOCE_RS06060	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
TOCE_RS06065	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
TOCE_RS06070	COG1058	Belongs to the CinA family
TOCE_RS06070	COG1546	Belongs to the CinA family
TOCE_RS06075	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
TOCE_RS06085	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TOCE_RS06090	COG1426	Protein conserved in bacteria
TOCE_RS06095	COG1674	ftsk spoiiie
TOCE_RS06105	COG0740	serine-type endopeptidase activity
TOCE_RS06125	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
TOCE_RS06130	COG1873	PFAM PRC-barrel domain
TOCE_RS06135	COG0756	dUTP diphosphatase activity
TOCE_RS06140	COG0726	polysaccharide deacetylase
TOCE_RS06145	COG1185	polyribonucleotide nucleotidyltransferase activity
TOCE_RS06150	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
TOCE_RS06155	COG0196	riboflavin kinase activity
TOCE_RS06160	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
TOCE_RS06170	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
TOCE_RS06180	COG1358	cellular component organization or biogenesis
TOCE_RS06185	COG2740	Nucleic-acid-binding protein implicated in transcription termination
TOCE_RS06190	COG0195	Participates in both transcription termination and antitermination
TOCE_RS06195	COG0779	Required for maturation of 30S ribosomal subunits
TOCE_RS06200	COG2176	DNA-directed DNA polymerase activity
TOCE_RS06205	COG1285	pathogenesis
TOCE_RS06210	COG0463	Glycosyl transferase, family 2
TOCE_RS06220	COG0442	prolyl-tRNA aminoacylation
TOCE_RS06235	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
TOCE_RS06240	COG0750	zinc metalloprotease
TOCE_RS06245	COG0628	permease
TOCE_RS06250	COG4589	Belongs to the CDS family
TOCE_RS06255	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
TOCE_RS06260	COG0233	cytoplasmic translational termination
TOCE_RS06265	COG0528	UMP kinase activity
TOCE_RS06270	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
TOCE_RS06275	COG0052	Belongs to the universal ribosomal protein uS2 family
TOCE_RS06280	COG1924	4 iron, 4 sulfur cluster binding
TOCE_RS06305	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
TOCE_RS06335	COG1366	Belongs to the anti-sigma-factor antagonist family
TOCE_RS06340	COG1686	Belongs to the peptidase S11 family
TOCE_RS06345	COG4974	Belongs to the 'phage' integrase family
TOCE_RS06350	COG1300	Membrane
TOCE_RS06355	COG1379	DNA repair
TOCE_RS06360	COG0494	nUDIX hydrolase
TOCE_RS06400	COG2369	cell adhesion
TOCE_RS06495	COG0750	zinc metalloprotease
TOCE_RS06500	COG0497	DNA recombination
TOCE_RS06505	COG1438	arginine binding
TOCE_RS06510	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
TOCE_RS06520	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
TOCE_RS06540	COG1722	exodeoxyribonuclease VII activity
TOCE_RS06545	COG1570	exodeoxyribonuclease VII activity
TOCE_RS06550	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
TOCE_RS06565	COG1302	Protein conserved in bacteria
TOCE_RS06605	COG3854	ATPases associated with a variety of cellular activities
TOCE_RS06615	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
TOCE_RS06620	COG0006	proline dipeptidase activity
TOCE_RS06625	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
TOCE_RS06665	COG2165	general secretion pathway protein
TOCE_RS06670	COG1459	type II secretion system
TOCE_RS06675	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
TOCE_RS06680	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
TOCE_RS06690	COG0768	penicillin binding
TOCE_RS06695	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
TOCE_RS06710	COG0735	belongs to the Fur family
TOCE_RS06715	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
TOCE_RS06730	COG0163	prenyltransferase activity
TOCE_RS06735	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
TOCE_RS06740	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
TOCE_RS06760	COG0667	Aldo Keto reductase
TOCE_RS06765	COG4472	Bacterial protein of unknown function (DUF965)
TOCE_RS06770	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
TOCE_RS06780	COG1937	Protein conserved in bacteria
TOCE_RS06785	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
TOCE_RS06790	COG0124	histidyl-tRNA synthetase
TOCE_RS06795	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TOCE_RS06805	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TOCE_RS06810	COG1490	D-aminoacyl-tRNA deacylase activity
TOCE_RS06815	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
TOCE_RS06820	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
TOCE_RS06825	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
TOCE_RS06825	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
TOCE_RS06845	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
TOCE_RS06850	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
TOCE_RS06860	COG1862	Preprotein translocase
TOCE_RS06875	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
TOCE_RS06880	COG2385	sporulation resulting in formation of a cellular spore
TOCE_RS06890	COG2255	four-way junction helicase activity
TOCE_RS06895	COG0632	four-way junction helicase activity
TOCE_RS06900	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
TOCE_RS06910	COG0217	transcriptional regulatory protein
TOCE_RS06915	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
TOCE_RS06920	COG1739	Uncharacterized protein family UPF0029
TOCE_RS06965	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
TOCE_RS06975	COG1683	Conserved Protein
TOCE_RS06980	COG1193	negative regulation of DNA recombination
TOCE_RS06985	COG0826	peptidase U32
TOCE_RS06990	COG1796	DNA polymerase
TOCE_RS06990	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
TOCE_RS06995	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
TOCE_RS07000	COG0072	phenylalanine-tRNA ligase activity
TOCE_RS07000	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TOCE_RS07005	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
TOCE_RS07010	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
TOCE_RS07015	COG0569	domain protein
TOCE_RS07020	COG0569	domain protein
TOCE_RS07025	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
TOCE_RS07030	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
TOCE_RS07035	COG0291	Belongs to the bacterial ribosomal protein bL35 family
TOCE_RS07040	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
TOCE_RS07045	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
TOCE_RS07050	COG4399	Belongs to the UPF0754 family
TOCE_RS07050	COG4399	Belongs to the UPF0754 family
TOCE_RS07130	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
TOCE_RS07135	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
TOCE_RS07150	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
TOCE_RS07160	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
TOCE_RS07170	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
TOCE_RS07175	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TOCE_RS07180	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
TOCE_RS07185	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
TOCE_RS07195	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
TOCE_RS07200	COG0508	dehydrogenase complex catalyzes the overall conversion of
TOCE_RS07205	COG0022	dehydrogenase e1 component
TOCE_RS07210	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
TOCE_RS07225	COG3732	PTS system glucitol sorbitol-specific
TOCE_RS07235	COG0459	protein refolding
TOCE_RS07240	COG2390	Transcriptional regulator
TOCE_RS07245	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
TOCE_RS07260	COG1063	alcohol dehydrogenase
TOCE_RS07265	COG3775	system Galactitol-specific IIC component
TOCE_RS07275	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
TOCE_RS07280	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
TOCE_RS07280	COG3933	PFAM sigma-54 factor interaction domain-containing protein
TOCE_RS07285	COG0322	excinuclease ABC activity
TOCE_RS07295	COG1763	Mo-molybdopterin cofactor biosynthetic process
TOCE_RS07300	COG1115	amino acid carrier protein
TOCE_RS07310	COG0686	Belongs to the AlaDH PNT family
TOCE_RS07315	COG5002	protein histidine kinase activity
TOCE_RS07320	COG0745	RESPONSE REGULATOR receiver
TOCE_RS07355	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
TOCE_RS07360	COG0301	tRNA thio-modification
TOCE_RS07365	COG1104	cysteine desulfurase activity
TOCE_RS07380	COG5577	PFAM Coat F domain
TOCE_RS07390	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
TOCE_RS07410	COG1228	amidohydrolase
TOCE_RS07420	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
TOCE_RS07425	COG2986	histidine ammonia-lyase
TOCE_RS07430	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
TOCE_RS07445	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TOCE_RS07450	COG0583	DNA-binding transcription factor activity
TOCE_RS07455	COG1489	DNA binding
TOCE_RS07470	COG5012	cobalamin binding
TOCE_RS07495	COG1757	Na H antiporter
TOCE_RS07505	COG3829	transcription factor binding
TOCE_RS07520	COG0617	tRNA 3'-terminal CCA addition
TOCE_RS07525	COG0622	Phosphoesterase
TOCE_RS07530	COG0151	Belongs to the GarS family
TOCE_RS07535	COG0138	bifunctional purine biosynthesis protein purh
TOCE_RS07540	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
TOCE_RS07545	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
TOCE_RS07550	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
TOCE_RS07555	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
TOCE_RS07560	COG0047	phosphoribosylformylglycinamidine synthase activity
TOCE_RS07565	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
TOCE_RS07570	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
TOCE_RS07575	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
TOCE_RS07600	COG0436	Aminotransferase
TOCE_RS07605	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
TOCE_RS07610	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
TOCE_RS07620	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
TOCE_RS07620	COG1796	DNA polymerase
TOCE_RS07625	COG0778	Nitroreductase
TOCE_RS07645	COG1309	transcriptional regulator
TOCE_RS07650	COG0142	geranyltranstransferase activity
TOCE_RS07680	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
TOCE_RS07685	COG3409	Peptidoglycan-binding domain 1 protein
TOCE_RS07685	COG0793	Belongs to the peptidase S41A family
TOCE_RS07710	COG1410	methionine synthase
TOCE_RS07710	COG0646	methionine synthase
TOCE_RS07720	COG1962	PFAM Tetrahydromethanopterin S-methyltransferase MtrH subunit
TOCE_RS07755	COG1366	Belongs to the anti-sigma-factor antagonist family
TOCE_RS07795	COG0583	DNA-binding transcription factor activity
TOCE_RS07805	COG2132	Multicopper oxidase
TOCE_RS07810	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
TOCE_RS07820	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
TOCE_RS07845	COG0733	neurotransmitter:sodium symporter activity
TOCE_RS07860	COG0280	phosphate acetyltransferase
TOCE_RS07865	COG3426	butyrate kinase activity
TOCE_RS07875	COG3829	transcription factor binding
TOCE_RS07875	COG3290	protein histidine kinase activity
TOCE_RS07885	COG1126	abc transporter atp-binding protein
TOCE_RS07890	COG0765	amino acid transport
TOCE_RS07895	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
TOCE_RS07915	COG2189	Belongs to the N(4) N(6)-methyltransferase family
TOCE_RS07925	COG1516	flagellar protein fliS
TOCE_RS07930	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
TOCE_RS07950	COG2610	gluconate transmembrane transporter activity
TOCE_RS07960	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
TOCE_RS07970	COG0463	Glycosyl transferase, family 2
TOCE_RS07970	COG1216	Glycosyl transferase, family 2
TOCE_RS07995	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
TOCE_RS08000	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
TOCE_RS08010	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
TOCE_RS08015	COG1256	bacterial-type flagellum assembly
TOCE_RS08015	COG4786	Flagellar basal body rod
TOCE_RS08040	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
TOCE_RS08045	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
TOCE_RS08055	COG1704	LemA family
TOCE_RS08060	COG2358	TRAP transporter, solute receptor (TAXI family
TOCE_RS08075	COG1971	Probably functions as a manganese efflux pump
TOCE_RS08110	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
TOCE_RS08115	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
TOCE_RS08135	COG3118	belongs to the thioredoxin family
TOCE_RS08160	COG0640	Transcriptional regulator
TOCE_RS08225	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
TOCE_RS08240	COG1132	(ABC) transporter
TOCE_RS08245	COG1132	(ABC) transporter
TOCE_RS08260	COG0105	UTP biosynthetic process
TOCE_RS08265	COG0352	thiamine-phosphate diphosphorylase activity
TOCE_RS08270	COG0739	heme binding
TOCE_RS08270	COG0741	lytic transglycosylase activity
TOCE_RS08270	COG1196	nuclear chromosome segregation
TOCE_RS08275	COG0237	dephospho-CoA kinase activity
TOCE_RS08285	COG1396	sequence-specific DNA binding
TOCE_RS08315	COG1376	ErfK ybiS ycfS ynhG family protein
TOCE_RS08325	COG2267	carboxylic ester hydrolase activity
TOCE_RS08330	COG1151	hydroxylamine reductase activity
TOCE_RS08375	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
TOCE_RS08380	COG0556	nucleotide-excision repair
TOCE_RS08385	COG1132	(ABC) transporter
TOCE_RS08405	COG3547	Transposase (IS116 IS110 IS902 family)
TOCE_RS08415	COG5275	peptidyl-tyrosine sulfation
TOCE_RS08415	COG0252	asparaginase activity
TOCE_RS08420	COG5275	peptidyl-tyrosine sulfation
TOCE_RS08420	COG0252	asparaginase activity
TOCE_RS08425	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
TOCE_RS08430	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
TOCE_RS08440	COG5275	peptidyl-tyrosine sulfation
TOCE_RS08440	COG0252	asparaginase activity
TOCE_RS08445	COG4656	Part of a membrane complex involved in electron transport
TOCE_RS08450	COG2204	response regulator
TOCE_RS08460	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TOCE_RS08465	COG3409	Peptidoglycan-binding domain 1 protein
TOCE_RS08465	COG0793	Belongs to the peptidase S41A family
TOCE_RS08470	COG0739	heme binding
TOCE_RS08475	COG2177	Part of the ABC transporter FtsEX involved in
TOCE_RS08480	COG2884	Cell division ATP-binding protein ftsE
TOCE_RS08485	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
TOCE_RS08490	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
TOCE_RS08490	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
TOCE_RS08500	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
TOCE_RS08500	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
TOCE_RS08520	COG0789	Transcriptional regulator
TOCE_RS08525	COG1486	melibiose metabolic process
TOCE_RS08530	COG3958	Transketolase
TOCE_RS08535	COG3959	Transketolase, thiamine diphosphate binding domain
TOCE_RS08540	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
TOCE_RS08565	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
TOCE_RS08570	COG0653	protein targeting
TOCE_RS08590	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
TOCE_RS08590	COG1918	ferrous iron import across plasma membrane
TOCE_RS08595	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
TOCE_RS08600	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
TOCE_RS08610	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
TOCE_RS08615	COG3859	Proton-coupled thiamine transporter YuaJ
TOCE_RS08625	COG1527	subunit (C
TOCE_RS08630	COG1269	ATP hydrolysis coupled proton transport
TOCE_RS08640	COG1436	Produces ATP from ADP in the presence of a proton gradient across the membrane
TOCE_RS08660	COG1394	ATPase activity, coupled to movement of substances
TOCE_RS08680	COG0142	geranyltranstransferase activity
TOCE_RS08685	COG1252	NADH dehydrogenase
TOCE_RS08700	COG1331	Highly conserved protein containing a thioredoxin domain
TOCE_RS08710	COG1533	DNA photolyase activity
TOCE_RS08715	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
TOCE_RS08730	COG4555	ABC transporter
TOCE_RS08735	COG0366	Alpha amylase catalytic
TOCE_RS08740	COG2207	Transcriptional regulator
TOCE_RS08740	COG4753	response regulator
TOCE_RS08750	COG1653	transport
TOCE_RS08765	COG1191	sigma factor activity
TOCE_RS08780	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
TOCE_RS08810	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
TOCE_RS08820	COG4496	protein, YerC YecD
TOCE_RS08825	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
TOCE_RS08830	COG0671	phosphoesterase, PA-phosphatase related
TOCE_RS08840	COG1854	S-ribosylhomocysteine lyase activity
TOCE_RS08845	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
TOCE_RS08850	COG0470	DNA polymerase III
TOCE_RS08850	COG1067	ATP-dependent peptidase activity
TOCE_RS08855	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
TOCE_RS08860	COG0740	serine-type endopeptidase activity
TOCE_RS08865	COG0544	peptidyl-prolyl cis-trans isomerase activity
TOCE_RS08905	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
TOCE_RS08945	COG1404	Belongs to the peptidase S8 family
TOCE_RS08960	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
TOCE_RS08970	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
TOCE_RS08975	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
TOCE_RS08980	COG5401	PFAM Sporulation and spore germination
TOCE_RS08985	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
TOCE_RS08990	COG0860	N-Acetylmuramoyl-L-alanine amidase
TOCE_RS08995	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
TOCE_RS09000	COG1757	Na H antiporter
TOCE_RS09020	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
TOCE_RS09035	COG1592	Rubrerythrin
TOCE_RS09045	COG2247	cell wall binding repeat
TOCE_RS09045	COG0860	N-Acetylmuramoyl-L-alanine amidase
TOCE_RS09050	COG2814	Major facilitator Superfamily
TOCE_RS09070	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
TOCE_RS09075	COG1760	l-serine dehydratase
TOCE_RS09080	COG1760	l-serine dehydratase
TOCE_RS09085	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
TOCE_RS09100	COG3842	ATPase activity
TOCE_RS09105	COG3835	regulator
TOCE_RS09110	COG0728	peptidoglycan biosynthetic process
TOCE_RS09120	COG0191	fructose-bisphosphate aldolase activity
TOCE_RS09125	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
TOCE_RS09155	COG0037	tRNA processing
TOCE_RS09160	COG2104	thiamine diphosphate biosynthetic process
TOCE_RS09165	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
TOCE_RS09170	COG0557	exoribonuclease II activity
TOCE_RS09175	COG1418	mRNA catabolic process
TOCE_RS09190	COG1592	Rubrerythrin
TOCE_RS09215	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
TOCE_RS09220	COG4770	biotin carboxylase activity
TOCE_RS09230	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
TOCE_RS09235	COG0346	lactoylglutathione lyase activity
TOCE_RS09240	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
TOCE_RS09240	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
TOCE_RS09245	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
TOCE_RS09245	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
TOCE_RS09255	COG0427	acetyl-CoA hydrolase
TOCE_RS09275	COG1984	allophanate hydrolase subunit 2
TOCE_RS09280	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
TOCE_RS09285	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
TOCE_RS09295	COG3852	Histidine kinase
TOCE_RS09300	COG2204	response regulator
TOCE_RS09305	COG1914	H( )-stimulated, divalent metal cation uptake system
TOCE_RS09310	COG0598	Magnesium transport protein CorA
TOCE_RS09315	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
TOCE_RS09320	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
TOCE_RS09325	COG0148	phosphopyruvate hydratase activity
TOCE_RS09335	COG0149	triose-phosphate isomerase activity
TOCE_RS09340	COG0126	phosphoglycerate kinase activity
TOCE_RS09355	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
TOCE_RS09370	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
TOCE_RS09375	COG2033	superoxide reductase activity
TOCE_RS09405	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
TOCE_RS09410	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
TOCE_RS09415	COG1473	amidohydrolase
TOCE_RS09420	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
TOCE_RS09430	COG1879	ABC-type sugar transport system periplasmic component
TOCE_RS09435	COG1172	Belongs to the binding-protein-dependent transport system permease family
TOCE_RS09440	COG1129	ABC transporter
TOCE_RS09455	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
TOCE_RS09465	COG1609	Transcriptional regulator
TOCE_RS09485	COG2252	PERMEase
TOCE_RS09495	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
TOCE_RS09515	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
TOCE_RS09520	COG0456	acetyltransferase
TOCE_RS09525	COG1214	PFAM Peptidase M22, glycoprotease
TOCE_RS09530	COG0802	atpase or kinase
TOCE_RS09535	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
TOCE_RS09540	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
TOCE_RS09545	COG0800	Aldolase
TOCE_RS09550	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
TOCE_RS09555	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
TOCE_RS09560	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
TOCE_RS09565	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
TOCE_RS09565	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
TOCE_RS09570	COG3716	PTS system mannose fructose sorbose family IID component
TOCE_RS09585	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
TOCE_RS09585	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
TOCE_RS09590	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
TOCE_RS09590	COG3933	PFAM sigma-54 factor interaction domain-containing protein
TOCE_RS09600	COG1297	OPT oligopeptide transporter protein
TOCE_RS09605	COG1228	amidohydrolase
TOCE_RS09610	COG2362	D-Aminopeptidase
TOCE_RS09615	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
TOCE_RS09620	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
TOCE_RS09625	COG2337	Toxic component of a toxin-antitoxin (TA) module
TOCE_RS09635	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
TOCE_RS09640	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
TOCE_RS09640	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
TOCE_RS09645	COG0736	holo-[acyl-carrier-protein] synthase activity
TOCE_RS09670	COG1077	Cell shape determining protein MreB Mrl
TOCE_RS09690	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
TOCE_RS09700	COG1459	type II secretion system
TOCE_RS09710	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
TOCE_RS09715	COG0454	-acetyltransferase
TOCE_RS09720	COG1396	sequence-specific DNA binding
TOCE_RS09720	COG1917	Cupin 2, conserved barrel domain protein
TOCE_RS09725	COG0006	proline dipeptidase activity
TOCE_RS09730	COG0531	amino acid
TOCE_RS09760	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
TOCE_RS09785	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
TOCE_RS09795	COG2189	Belongs to the N(4) N(6)-methyltransferase family
TOCE_RS09835	COG2801	Transposase and inactivated derivatives
TOCE_RS09855	COG1733	regulation of RNA biosynthetic process
TOCE_RS09870	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
TOCE_RS09880	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
TOCE_RS09885	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
TOCE_RS09895	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
TOCE_RS09905	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
TOCE_RS09910	COG0798	PFAM Bile acid sodium symporter
TOCE_RS09915	COG0640	Transcriptional regulator
TOCE_RS09920	COG0640	Transcriptional regulator
TOCE_RS09945	COG0709	Synthesizes selenophosphate from selenide and ATP
TOCE_RS09955	COG1447	Phosphotransferase system cellobiose-specific component IIA
TOCE_RS09960	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
TOCE_RS09965	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
TOCE_RS09975	COG3711	transcriptional antiterminator
TOCE_RS09980	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
TOCE_RS09985	COG0746	molybdenum cofactor guanylyltransferase activity
TOCE_RS10015	COG1827	regulation of RNA biosynthetic process
TOCE_RS10030	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
TOCE_RS10035	COG4187	Peptidase family M20/M25/M40
TOCE_RS10040	COG0428	transporter
TOCE_RS10045	COG3829	transcription factor binding
TOCE_RS10060	COG0745	RESPONSE REGULATOR receiver
TOCE_RS10085	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
TOCE_RS10100	COG4786	Flagellar basal body rod
TOCE_RS10105	COG1077	Cell shape determining protein MreB Mrl
TOCE_RS10110	COG1609	Transcriptional regulator
TOCE_RS10120	COG2385	sporulation resulting in formation of a cellular spore
TOCE_RS10125	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
TOCE_RS10140	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
TOCE_RS10145	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
TOCE_RS10150	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
TOCE_RS10155	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
TOCE_RS10160	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
TOCE_RS10160	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
TOCE_RS10165	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
TOCE_RS10180	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
TOCE_RS10185	COG0508	dehydrogenase complex catalyzes the overall conversion of
TOCE_RS10190	COG3199	ATP-NAD kinase
TOCE_RS10195	COG0022	dehydrogenase e1 component
TOCE_RS10200	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
TOCE_RS10225	COG2801	Transposase and inactivated derivatives
TOCE_RS10255	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
TOCE_RS10260	COG1436	Produces ATP from ADP in the presence of a proton gradient across the membrane
TOCE_RS10265	COG1527	subunit (C
TOCE_RS10275	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
TOCE_RS10280	COG1269	ATP hydrolysis coupled proton transport
TOCE_RS10300	COG1191	sigma factor activity
TOCE_RS10310	COG2233	PERMEase
TOCE_RS10335	COG1966	Carbon starvation protein
TOCE_RS10355	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
TOCE_RS10375	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
TOCE_RS10380	COG0698	ribose 5-phosphate isomerase
TOCE_RS10390	COG0009	L-threonylcarbamoyladenylate synthase
TOCE_RS10405	COG2890	protein-(glutamine-N5) methyltransferase activity
TOCE_RS10410	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
TOCE_RS10415	COG3872	metal-dependent enzyme
TOCE_RS10420	COG0254	rRNA binding
TOCE_RS10425	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
TOCE_RS10430	COG0454	-acetyltransferase
TOCE_RS10435	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
TOCE_RS10440	COG3885	ferrous iron binding
TOCE_RS10440	COG2078	PFAM AMMECR1 domain protein
TOCE_RS10445	COG5322	oxidoreductase activity
TOCE_RS10445	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
TOCE_RS10470	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
TOCE_RS10480	COG1592	Rubrerythrin
TOCE_RS10480	COG1773	rubredoxin
TOCE_RS10485	COG3547	Transposase (IS116 IS110 IS902 family)
TOCE_RS10515	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
TOCE_RS10530	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
TOCE_RS10535	COG0037	tRNA processing
TOCE_RS10560	COG0222	ribosome binding
TOCE_RS10565	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
TOCE_RS10570	COG0081	regulation of translation
TOCE_RS10575	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
TOCE_RS10580	COG0250	Participates in transcription elongation, termination and antitermination
TOCE_RS10590	COG0267	Belongs to the bacterial ribosomal protein bL33 family
TOCE_RS10595	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
TOCE_RS10600	COG3547	Transposase (IS116 IS110 IS902 family)
TOCE_RS10630	COG3688	RNA-binding protein containing a PIN domain
TOCE_RS10635	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
TOCE_RS10650	COG0215	cysteine-tRNA ligase activity
TOCE_RS10655	COG1045	serine acetyltransferase
TOCE_RS10660	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
TOCE_RS10665	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
TOCE_RS10670	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
TOCE_RS10675	COG4956	integral membrane protein (PIN domain superfamily)
TOCE_RS10680	COG1329	Transcriptional regulator
TOCE_RS10690	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
TOCE_RS10695	COG0542	response to heat
TOCE_RS10700	COG3869	Catalyzes the specific phosphorylation of arginine residues in
TOCE_RS10705	COG3880	PFAM UvrB UvrC protein
TOCE_RS10720	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
TOCE_RS10725	COG0516	GMP reductase activity
TOCE_RS10725	COG0517	IMP dehydrogenase activity
TOCE_RS10730	COG1301	dicarboxylic acid transport
TOCE_RS10745	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
TOCE_RS10750	COG0735	belongs to the Fur family
TOCE_RS10760	COG1752	Esterase of the alpha-beta hydrolase superfamily
TOCE_RS10765	COG1013	pyruvate-flavodoxin oxidoreductase activity
TOCE_RS10770	COG0674	pyruvate-flavodoxin oxidoreductase activity
TOCE_RS10775	COG1144	Oxidoreductase
TOCE_RS10780	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
TOCE_RS10805	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
TOCE_RS10810	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
TOCE_RS10815	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
TOCE_RS10855	COG0590	tRNA wobble adenosine to inosine editing
TOCE_RS10905	COG0456	acetyltransferase
TOCE_RS10925	COG1136	(ABC) transporter
TOCE_RS10925	COG0577	efflux transmembrane transporter activity
TOCE_RS10935	COG1136	(ABC) transporter
TOCE_RS10965	COG1136	(ABC) transporter
TOCE_RS10970	COG0577	efflux transmembrane transporter activity
TOCE_RS10970	COG1136	(ABC) transporter
TOCE_RS10995	COG0616	signal peptide processing
TOCE_RS11005	COG1067	ATP-dependent peptidase activity
TOCE_RS11010	COG0504	CTP synthase activity
TOCE_RS11015	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
TOCE_RS11020	COG3829	transcription factor binding
TOCE_RS11025	COG0018	arginyl-trna synthetase
TOCE_RS11035	COG0471	metal ion transport
TOCE_RS11035	COG3273	potassium ion transport
TOCE_RS11040	COG1125	glycine betaine transport
TOCE_RS11040	COG0517	IMP dehydrogenase activity
TOCE_RS11050	COG1732	Glycine betaine
TOCE_RS11055	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
TOCE_RS11060	COG2011	ABC-type metal ion transport system permease component
TOCE_RS11075	COG0252	asparaginase activity
TOCE_RS11085	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
TOCE_RS11100	COG1982	Orn Lys Arg decarboxylase major
TOCE_RS11115	COG0531	amino acid
TOCE_RS11120	COG0697	spore germination
TOCE_RS11140	COG0174	glutamine synthetase
TOCE_RS11145	COG0789	Transcriptional regulator
TOCE_RS11150	COG1802	Transcriptional regulator
TOCE_RS11170	COG0243	molybdopterin cofactor binding
TOCE_RS11190	COG1595	DNA-templated transcription, initiation
TOCE_RS11210	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
TOCE_RS11220	COG3875	lactate racemase activity
TOCE_RS11270	COG5002	protein histidine kinase activity
TOCE_RS11275	COG0745	RESPONSE REGULATOR receiver
TOCE_RS11285	COG1116	anion transmembrane transporter activity
TOCE_RS11285	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
TOCE_RS11300	COG2707	UPF0756 membrane protein
TOCE_RS11305	COG0739	heme binding
TOCE_RS11310	COG0308	aminopeptidase N
TOCE_RS11345	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
TOCE_RS11350	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
TOCE_RS11355	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
TOCE_RS11360	COG0305	Participates in initiation and elongation during chromosome replication
TOCE_RS11365	COG0359	binds to the 23S rRNA
TOCE_RS11370	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
TOCE_RS11385	COG0629	single-stranded DNA binding
TOCE_RS11390	COG0360	Binds together with S18 to 16S ribosomal RNA
TOCE_RS11400	COG0668	transmembrane transport
TOCE_RS11435	COG1597	lipid kinase activity
TOCE_RS11445	COG0739	heme binding
TOCE_RS11460	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
TOCE_RS11465	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
TOCE_RS11475	COG0840	transmembrane signaling receptor activity
TOCE_RS11480	COG1475	DNA binding
TOCE_RS11485	COG1192	Involved in chromosome partitioning
TOCE_RS11495	COG0357	Ribosomal RNA small subunit methyltransferase G
TOCE_RS11500	COG0445	tRNA wobble uridine modification
TOCE_RS11505	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
TOCE_RS11510	COG1847	R3H domain protein
TOCE_RS11515	COG0706	membrane insertase activity
TOCE_RS11520	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
TOCE_RS11530	COG0230	Belongs to the bacterial ribosomal protein bL34 family
TOCE_RS11555	COG0582	viral genome integration into host DNA
TOCE_RS11590	COG1876	peptidase activity
TOCE_RS11645	COG1376	ErfK ybiS ycfS ynhG family protein
TOCE_RS11660	COG0442	prolyl-tRNA aminoacylation
TOCE_RS11680	COG1126	abc transporter atp-binding protein
TOCE_RS11685	COG1126	abc transporter atp-binding protein
TOCE_RS11695	COG0457	Tetratricopeptide repeat
TOCE_RS11695	COG0463	Glycosyl transferase, family 2
TOCE_RS11705	COG0737	Belongs to the 5'-nucleotidase family
TOCE_RS11720	COG0463	Glycosyl transferase, family 2
TOCE_RS11740	COG0456	acetyltransferase
TOCE_RS11750	COG2205	protein histidine kinase activity