locus-tag	class	description
THA_RS00025	COG0513	Belongs to the DEAD box helicase family
THA_RS00030	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
THA_RS00065	COG2801	Transposase and inactivated derivatives
THA_RS00100	COG0730	response to heat
THA_RS00110	COG0768	penicillin binding
THA_RS00120	COG0275	rRNA processing
THA_RS00140	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
THA_RS00150	COG4608	Belongs to the ABC transporter superfamily
THA_RS00155	COG0444	Belongs to the ABC transporter superfamily
THA_RS00160	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
THA_RS00165	COG0601	transmembrane transport
THA_RS00170	COG0322	excinuclease ABC activity
THA_RS00180	COG0509	glycine decarboxylation via glycine cleavage system
THA_RS00190	COG1918	ferrous iron import across plasma membrane
THA_RS00190	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
THA_RS00205	COG1596	polysaccharide export
THA_RS00205	COG1555	photosystem II stabilization
THA_RS00210	COG1355	regulation of microtubule-based process
THA_RS00215	COG1450	Type ii and iii secretion system protein
THA_RS00245	COG1459	type II secretion system
THA_RS00250	COG1122	ATPase activity
THA_RS00255	COG2813	Specifically methylates the guanine in position
THA_RS00265	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
THA_RS00280	COG1059	Responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine 7-oxoG) from DNA. Also nicks DNA at apurinic apyrimidinic sites (AP sites)
THA_RS00290	COG0681	Belongs to the peptidase S26 family
THA_RS00295	COG0335	large ribosomal subunit rRNA binding
THA_RS00300	COG4752	Belongs to the RNA methyltransferase TrmD family
THA_RS00305	COG0336	Belongs to the RNA methyltransferase TrmD family
THA_RS00310	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
THA_RS00315	COG1837	Belongs to the UPF0109 family
THA_RS00320	COG0228	four-way junction DNA binding
THA_RS00325	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
THA_RS00335	COG1178	ABC-type Fe3 transport system permease component
THA_RS00345	COG0058	SHG alpha-glucan phosphorylase activity
THA_RS00350	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
THA_RS00360	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
THA_RS00370	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
THA_RS00370	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
THA_RS00380	COG0220	tRNA (guanine-N7-)-methyltransferase activity
THA_RS00385	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
THA_RS00410	COG1363	Peptidase, m42
THA_RS00445	COG2096	Adenosyltransferase
THA_RS00450	COG2986	histidine ammonia-lyase
THA_RS00455	COG0840	transmembrane signaling receptor activity
THA_RS00465	COG2201	protein-glutamate methylesterase activity
THA_RS00480	COG1013	pyruvate-flavodoxin oxidoreductase activity
THA_RS00485	COG2131	deaminase
THA_RS00490	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
THA_RS00495	COG1530	ribonuclease E activity
THA_RS00500	COG0572	uridine kinase
THA_RS00515	COG1923	regulation of RNA biosynthetic process
THA_RS00520	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
THA_RS00535	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
THA_RS00540	COG0268	Binds directly to 16S ribosomal RNA
THA_RS00575	COG1110	DNA topoisomerase II activity
THA_RS00580	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
THA_RS00595	COG5002	protein histidine kinase activity
THA_RS00600	COG0745	RESPONSE REGULATOR receiver
THA_RS00605	COG0704	Plays a role in the regulation of phosphate uptake
THA_RS00610	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
THA_RS00615	COG0573	inorganic phosphate transmembrane transporter activity
THA_RS00620	COG0581	inorganic phosphate transmembrane transporter activity
THA_RS00630	COG1012	belongs to the aldehyde dehydrogenase family
THA_RS00650	COG1105	Belongs to the carbohydrate kinase PfkB family
THA_RS00655	COG1028	Short-chain dehydrogenase reductase Sdr
THA_RS00665	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
THA_RS00670	COG0745	RESPONSE REGULATOR receiver
THA_RS00675	COG5002	protein histidine kinase activity
THA_RS00690	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
THA_RS00695	COG0166	Belongs to the GPI family
THA_RS00710	COG2199	diguanylate cyclase activity
THA_RS00715	COG0556	nucleotide-excision repair
THA_RS00720	COG1293	RNA-binding protein homologous to eukaryotic snRNP
THA_RS00745	COG1323	Belongs to the UPF0348 family
THA_RS00750	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
THA_RS00760	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
THA_RS00775	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
THA_RS00785	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
THA_RS00785	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
THA_RS00790	COG0235	Class ii aldolase
THA_RS00800	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
THA_RS00810	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
THA_RS00820	COG0840	transmembrane signaling receptor activity
THA_RS00845	COG2985	domain, Protein
THA_RS00845	COG0569	domain protein
THA_RS00850	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
THA_RS00860	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
THA_RS00865	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
THA_RS00870	COG2171	N-acyltransferase activity
THA_RS00880	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
THA_RS00890	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
THA_RS00895	COG0815	Transfers the fatty acyl group on membrane lipoproteins
THA_RS00905	COG0404	The glycine cleavage system catalyzes the degradation of glycine
THA_RS00910	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
THA_RS00915	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
THA_RS00920	COG1454	alcohol dehydrogenase
THA_RS00925	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
THA_RS00935	COG0494	nUDIX hydrolase
THA_RS00940	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
THA_RS00945	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
THA_RS00950	COG0674	pyruvate-flavodoxin oxidoreductase activity
THA_RS00950	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
THA_RS00960	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
THA_RS00970	COG1122	ATPase activity
THA_RS00975	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
THA_RS00980	COG0205	6-phosphofructokinase activity
THA_RS00990	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
THA_RS00995	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
THA_RS01000	COG1862	Preprotein translocase
THA_RS01005	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
THA_RS01015	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
THA_RS01020	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
THA_RS01035	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
THA_RS01055	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
THA_RS01055	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
THA_RS01070	COG1193	negative regulation of DNA recombination
THA_RS01080	COG0306	phosphate transporter
THA_RS01095	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
THA_RS01105	COG0280	phosphate acetyltransferase
THA_RS01115	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
THA_RS01120	COG1141	Ferredoxin
THA_RS01130	COG1744	ABC transporter substrate-binding protein PnrA-like
THA_RS01135	COG3845	ABC transporter
THA_RS01140	COG4603	Belongs to the binding-protein-dependent transport system permease family
THA_RS01145	COG1079	Belongs to the binding-protein-dependent transport system permease family
THA_RS01175	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
THA_RS01185	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
THA_RS01190	COG0542	response to heat
THA_RS01235	COG0492	ferredoxin-NADP+ reductase activity
THA_RS01240	COG1335	isochorismatase
THA_RS01245	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
THA_RS01250	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
THA_RS01260	COG1564	THIamine pyrophosphokinase
THA_RS01265	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
THA_RS01270	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
THA_RS01275	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
THA_RS01280	COG0546	phosphoglycolate phosphatase activity
THA_RS01285	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
THA_RS01295	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
THA_RS01300	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
THA_RS01300	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
THA_RS01305	COG0307	riboflavin synthase, alpha
THA_RS01310	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
THA_RS01310	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
THA_RS01335	COG0822	iron-sulfur transferase activity
THA_RS01340	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
THA_RS01345	COG0719	Fe-S assembly protein
THA_RS01350	COG0719	Fe-S assembly protein
THA_RS01360	COG0459	protein refolding
THA_RS01365	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
THA_RS01375	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
THA_RS01385	COG0312	modulator of DNA gyrase
THA_RS01390	COG0312	modulator of DNA gyrase
THA_RS01405	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
THA_RS01410	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
THA_RS01415	COG0442	prolyl-tRNA aminoacylation
THA_RS01420	COG0215	cysteine-tRNA ligase activity
THA_RS01425	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
THA_RS01430	COG2233	PERMEase
THA_RS01455	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
THA_RS01460	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
THA_RS01470	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
THA_RS01485	COG0297	glycogen (starch) synthase activity
THA_RS01495	COG3829	transcription factor binding
THA_RS01495	COG3290	protein histidine kinase activity
THA_RS01505	COG1181	Belongs to the D-alanine--D-alanine ligase family
THA_RS01520	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
THA_RS01525	COG2379	hydroxypyruvate reductase
THA_RS01530	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
THA_RS01535	COG0484	heat shock protein binding
THA_RS01540	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
THA_RS01550	COG0477	Major facilitator Superfamily
THA_RS01555	COG1827	regulation of RNA biosynthetic process
THA_RS01620	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
THA_RS01625	COG1518	maintenance of DNA repeat elements
THA_RS01630	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
THA_RS01640	COG2801	Transposase and inactivated derivatives
THA_RS01645	COG1047	Peptidyl-prolyl cis-trans
THA_RS01660	COG1363	Peptidase, m42
THA_RS01670	COG1758	RNA polymerase activity
THA_RS01675	COG0194	GDP metabolic process
THA_RS01680	COG2052	Domain of unknown function (DUF370)
THA_RS01705	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
THA_RS01715	COG3426	butyrate kinase activity
THA_RS01720	COG0280	phosphate acetyltransferase
THA_RS01725	COG3426	butyrate kinase activity
THA_RS01730	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
THA_RS01735	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
THA_RS01740	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
THA_RS01750	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
THA_RS01755	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
THA_RS01770	COG0167	dihydroorotate dehydrogenase activity
THA_RS01800	COG2359	stage V sporulation protein S
THA_RS01805	COG0737	Belongs to the 5'-nucleotidase family
THA_RS01810	COG1132	(ABC) transporter
THA_RS01840	COG0301	tRNA thio-modification
THA_RS01865	COG2217	Heavy metal translocating P-type atpase
THA_RS01870	COG1937	Protein conserved in bacteria
THA_RS01875	COG1132	(ABC) transporter
THA_RS01925	COG1164	Oligoendopeptidase f
THA_RS01930	COG0534	Mate efflux family protein
THA_RS01940	COG0667	Aldo Keto reductase
THA_RS01955	COG1131	(ABC) transporter
THA_RS01965	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
THA_RS01965	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
THA_RS01970	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
THA_RS01970	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
THA_RS01985	COG1573	uracil-dna glycosylase
THA_RS01990	COG0574	Belongs to the PEP-utilizing enzyme family
THA_RS01990	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
THA_RS02000	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
THA_RS02005	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
THA_RS02010	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
THA_RS02015	COG0193	aminoacyl-tRNA hydrolase activity
THA_RS02035	COG0529	Catalyzes the synthesis of activated sulfate
THA_RS02040	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
THA_RS02045	COG4974	Belongs to the 'phage' integrase family
THA_RS02050	COG0148	phosphopyruvate hydratase activity
THA_RS02060	COG0497	DNA recombination
THA_RS02065	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
THA_RS02075	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
THA_RS02080	COG0116	Belongs to the methyltransferase superfamily
THA_RS02085	COG1993	acr, cog1993
THA_RS02090	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
THA_RS02100	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
THA_RS02105	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
THA_RS02115	COG2264	protein methyltransferase activity
THA_RS02120	COG0739	heme binding
THA_RS02125	COG1607	acyl-coa hydrolase
THA_RS02130	COG3246	L-lysine catabolic process to acetate
THA_RS02135	COG0604	alcohol dehydrogenase
THA_RS02140	COG1509	lysine 2,3-aminomutase activity
THA_RS02145	COG2030	dehydratase
THA_RS02160	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
THA_RS02165	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
THA_RS02180	COG1136	(ABC) transporter
THA_RS02210	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
THA_RS02220	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
THA_RS02225	COG0037	tRNA processing
THA_RS02240	COG1968	undecaprenyl-diphosphatase activity
THA_RS02245	COG1228	amidohydrolase
THA_RS02260	COG0424	maF-like protein
THA_RS02265	COG2003	Belongs to the UPF0758 family
THA_RS02280	COG1215	transferase activity, transferring glycosyl groups
THA_RS02285	COG1216	Glycosyl transferase, family 2
THA_RS02310	COG0793	Belongs to the peptidase S41A family
THA_RS02315	COG2226	methyltransferase
THA_RS02330	COG1713	HD superfamily hydrolase involved in NAD metabolism
THA_RS02340	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
THA_RS02345	COG0009	L-threonylcarbamoyladenylate synthase
THA_RS02355	COG0481	GTPase activity
THA_RS02360	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
THA_RS02365	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
THA_RS02370	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
THA_RS02385	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
THA_RS02395	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
THA_RS02400	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
THA_RS02410	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
THA_RS02415	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
THA_RS02420	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
THA_RS02425	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
THA_RS02440	COG1461	Dihydroxyacetone kinase
THA_RS02450	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
THA_RS02455	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
THA_RS02460	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
THA_RS02465	COG1785	Belongs to the alkaline phosphatase family
THA_RS02475	COG0495	leucyl-tRNA aminoacylation
THA_RS02510	COG0714	Associated with various cellular activities
THA_RS02540	COG0750	zinc metalloprotease
THA_RS02560	COG3437	response regulator, receiver
THA_RS02565	COG2801	Transposase and inactivated derivatives
THA_RS02575	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
THA_RS02585	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
THA_RS02590	COG0543	2 iron, 2 sulfur cluster binding
THA_RS02595	COG0167	dihydroorotate dehydrogenase activity
THA_RS02600	COG0284	orotidine-5'-phosphate decarboxylase activity
THA_RS02605	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
THA_RS02615	COG2183	response to ionizing radiation
THA_RS02620	COG0835	chemotaxis
THA_RS02625	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
THA_RS02635	COG1013	pyruvate-flavodoxin oxidoreductase activity
THA_RS02640	COG0674	pyruvate-flavodoxin oxidoreductase activity
THA_RS02645	COG1144	Oxidoreductase
THA_RS02650	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
THA_RS02655	COG1543	Belongs to the glycosyl hydrolase 57 family
THA_RS02665	COG1760	l-serine dehydratase
THA_RS02695	COG0784	Response regulator, receiver
THA_RS02695	COG3437	response regulator, receiver
THA_RS02715	COG1256	bacterial-type flagellum assembly
THA_RS02715	COG4786	Flagellar basal body rod
THA_RS02715	COG4786	Flagellar basal body rod
THA_RS02715	COG1256	bacterial-type flagellum assembly
THA_RS02730	COG0840	transmembrane signaling receptor activity
THA_RS02735	COG0668	transmembrane transport
THA_RS02740	COG0180	Tryptophanyl-tRNA synthetase
THA_RS02745	COG1067	ATP-dependent peptidase activity
THA_RS02750	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
THA_RS02765	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
THA_RS02775	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
THA_RS02780	COG0537	adenosine 5'-monophosphoramidase activity
THA_RS02790	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
THA_RS02795	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
THA_RS02825	COG2759	Belongs to the formate--tetrahydrofolate ligase family
THA_RS02830	COG5002	protein histidine kinase activity
THA_RS02835	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
THA_RS02845	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
THA_RS02845	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
THA_RS02850	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
THA_RS02860	COG0006	proline dipeptidase activity
THA_RS02880	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
THA_RS02885	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
THA_RS02890	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
THA_RS02895	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
THA_RS02905	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
THA_RS02910	COG0355	proton-transporting ATP synthase activity, rotational mechanism
THA_RS02915	COG1307	EDD domain protein, DegV family
THA_RS02925	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
THA_RS02930	COG5002	protein histidine kinase activity
THA_RS02935	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
THA_RS02950	COG0095	Lipoate-protein ligase
THA_RS02955	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
THA_RS02960	COG1278	Cold shock
THA_RS02970	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
THA_RS03000	COG0196	riboflavin kinase activity
THA_RS03005	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
THA_RS03020	COG2252	PERMEase
THA_RS03030	COG2801	Transposase and inactivated derivatives
THA_RS03040	COG3547	Transposase (IS116 IS110 IS902 family)
THA_RS03110	COG1609	Transcriptional regulator
THA_RS03115	COG1966	Carbon starvation protein
THA_RS03120	COG3279	Response regulator of the LytR AlgR family
THA_RS03125	COG3275	phosphorelay sensor kinase activity
THA_RS03135	COG0395	ABC-type sugar transport system, permease component
THA_RS03150	COG2373	Large extracellular alpha-helical protein
THA_RS03160	COG3234	Protein of unknown function (DUF1175)
THA_RS03165	COG0823	Involved in the tonB-independent uptake of proteins
THA_RS03165	COG4946	Tricorn protease homolog
THA_RS03165	COG1506	peptidase
THA_RS03170	COG0733	neurotransmitter:sodium symporter activity
THA_RS03175	COG3706	GGDEF domain
THA_RS03180	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
THA_RS03190	COG5001	Diguanylate cyclase
THA_RS03210	COG0081	regulation of translation
THA_RS03215	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
THA_RS03220	COG0250	Participates in transcription elongation, termination and antitermination
THA_RS03225	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
THA_RS03235	COG0267	Belongs to the bacterial ribosomal protein bL33 family
THA_RS03250	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
THA_RS03255	COG0629	single-stranded DNA binding
THA_RS03260	COG0360	Binds together with S18 to 16S ribosomal RNA
THA_RS03275	COG0772	Belongs to the SEDS family
THA_RS03285	COG0752	glycyl-tRNA synthetase alpha subunit
THA_RS03295	COG1592	Rubrerythrin
THA_RS03300	COG0330	HflC and HflK could
THA_RS03305	COG0330	HflC and HflK could
THA_RS03310	COG0517	IMP dehydrogenase activity
THA_RS03310	COG0516	GMP reductase activity
THA_RS03315	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
THA_RS03320	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
THA_RS03340	COG1122	ATPase activity
THA_RS03350	COG3706	GGDEF domain
THA_RS03375	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
THA_RS03390	COG1525	nuclease
THA_RS03410	COG1869	D-ribose catabolic process
THA_RS03415	COG1129	ABC transporter
THA_RS03420	COG1172	Belongs to the binding-protein-dependent transport system permease family
THA_RS03425	COG1879	ABC-type sugar transport system periplasmic component
THA_RS03435	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
THA_RS03445	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
THA_RS03450	COG1328	CTP reductase activity
THA_RS03475	COG0719	Fe-S assembly protein
THA_RS03490	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
THA_RS03505	COG1175	transmembrane transport
THA_RS03510	COG3833	ABC-type maltose transport systems, permease component
THA_RS03555	COG1805	sodium ion transport
THA_RS03570	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
THA_RS03575	COG0463	Glycosyl transferase, family 2
THA_RS03580	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
THA_RS03595	COG1233	COG1233 Phytoene dehydrogenase and related
THA_RS03615	COG3706	GGDEF domain
THA_RS03620	COG0542	response to heat
THA_RS03625	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
THA_RS03635	COG4399	Belongs to the UPF0754 family
THA_RS03640	COG4399	Belongs to the UPF0754 family
THA_RS03645	COG1187	pseudouridine synthase activity
THA_RS03655	COG1074	ATP-dependent DNA helicase activity
THA_RS03670	COG1307	EDD domain protein, DegV family
THA_RS03675	COG2801	Transposase and inactivated derivatives
THA_RS03680	COG1307	EDD domain protein, DegV family
THA_RS03685	COG0776	regulation of translation
THA_RS03690	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
THA_RS03695	COG0432	Pfam Uncharacterised protein family UPF0047
THA_RS03705	COG0803	Belongs to the bacterial solute-binding protein 9 family
THA_RS03710	COG1121	(ABC) transporter
THA_RS03715	COG1108	ABC-type Mn2 Zn2 transport systems permease components
THA_RS03725	COG1960	acyl-CoA dehydrogenase activity
THA_RS03730	COG2086	electron transfer activity
THA_RS03735	COG3547	Transposase (IS116 IS110 IS902 family)
THA_RS03760	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
THA_RS03765	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
THA_RS03770	COG0138	bifunctional purine biosynthesis protein purh
THA_RS03775	COG0151	Belongs to the GarS family
THA_RS03785	COG0438	transferase activity, transferring glycosyl groups
THA_RS03785	COG0297	glycogen (starch) synthase activity
THA_RS03805	COG0297	glycogen (starch) synthase activity
THA_RS03805	COG0438	transferase activity, transferring glycosyl groups
THA_RS03840	COG1131	(ABC) transporter
THA_RS03865	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
THA_RS03870	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
THA_RS03885	COG0436	Aminotransferase
THA_RS03890	COG2045	Belongs to the ComB family
THA_RS03905	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
THA_RS03935	COG0601	transmembrane transport
THA_RS03945	COG0444	Belongs to the ABC transporter superfamily
THA_RS03950	COG4608	Belongs to the ABC transporter superfamily
THA_RS03955	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
THA_RS03960	COG2723	6-phospho-beta-galactosidase activity
THA_RS03965	COG1609	Transcriptional regulator
THA_RS03975	COG0105	UTP biosynthetic process
THA_RS03985	COG3864	Putative metallopeptidase domain
THA_RS03995	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
THA_RS04025	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
THA_RS04030	COG2801	Transposase and inactivated derivatives
THA_RS04035	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
THA_RS04040	COG2267	carboxylic ester hydrolase activity
THA_RS04045	COG1181	Belongs to the D-alanine--D-alanine ligase family
THA_RS04050	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
THA_RS04055	COG1406	Chemotaxis phosphatase CheX
THA_RS04060	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
THA_RS04065	COG0528	UMP kinase activity
THA_RS04080	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
THA_RS04085	COG2176	DNA-directed DNA polymerase activity
THA_RS04090	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
THA_RS04095	COG1766	The M ring may be actively involved in energy transduction
THA_RS04110	COG0333	Belongs to the bacterial ribosomal protein bL32 family
THA_RS04115	COG0416	fatty acid biosynthetic process
THA_RS04120	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
THA_RS04125	COG0612	Peptidase, M16
THA_RS04130	COG0612	Peptidase, M16
THA_RS04140	COG4786	Flagellar basal body rod
THA_RS04145	COG1077	Cell shape determining protein MreB Mrl
THA_RS04185	COG1132	(ABC) transporter
THA_RS04190	COG1151	hydroxylamine reductase activity
THA_RS04195	COG1785	Belongs to the alkaline phosphatase family
THA_RS04205	COG0305	Participates in initiation and elongation during chromosome replication
THA_RS04210	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
THA_RS04225	COG0697	spore germination
THA_RS04235	COG2211	Major facilitator Superfamily
THA_RS04240	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
THA_RS04245	COG0745	RESPONSE REGULATOR receiver
THA_RS04250	COG1523	belongs to the glycosyl hydrolase 13 family
THA_RS04290	COG0438	transferase activity, transferring glycosyl groups
THA_RS04295	COG1653	transport
THA_RS04310	COG0154	amidase activity
THA_RS04335	COG3547	Transposase (IS116 IS110 IS902 family)
THA_RS04355	COG1337	RAMP superfamily
THA_RS04400	COG1088	dTDP-glucose 4,6-dehydratase activity
THA_RS04415	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
THA_RS04455	COG1215	transferase activity, transferring glycosyl groups
THA_RS04465	COG0438	transferase activity, transferring glycosyl groups
THA_RS04495	COG0438	transferase activity, transferring glycosyl groups
THA_RS04505	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
THA_RS04555	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
THA_RS04565	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
THA_RS04570	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
THA_RS04600	COG1706	bacterial-type flagellum-dependent cell motility
THA_RS04615	COG0187	DNA topoisomerase II activity
THA_RS04625	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
THA_RS04630	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
THA_RS04635	COG0516	GMP reductase activity
THA_RS04635	COG0517	IMP dehydrogenase activity
THA_RS04640	COG1105	Belongs to the carbohydrate kinase PfkB family
THA_RS04645	COG1131	(ABC) transporter
THA_RS04680	COG1007	ATP synthesis coupled electron transport
THA_RS04685	COG0205	6-phosphofructokinase activity
THA_RS04700	COG1979	alcohol dehydrogenase
THA_RS04710	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
THA_RS04715	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
THA_RS04715	COG0072	phenylalanine-tRNA ligase activity
THA_RS04735	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
THA_RS04745	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
THA_RS04760	COG1175	transmembrane transport
THA_RS04765	COG0395	ABC-type sugar transport system, permease component
THA_RS04775	COG3706	GGDEF domain
THA_RS04780	COG0445	tRNA wobble uridine modification
THA_RS04785	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
THA_RS04795	COG1392	Phosphate transport regulator
THA_RS04800	COG0366	Alpha amylase catalytic
THA_RS04805	COG0306	phosphate transporter
THA_RS04810	COG0306	phosphate transporter
THA_RS04830	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
THA_RS04835	COG4869	propanediol catabolic process
THA_RS04840	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
THA_RS04845	COG0840	transmembrane signaling receptor activity
THA_RS04850	COG1684	flagellar biosynthetic protein fliR
THA_RS04855	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
THA_RS04865	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
THA_RS04875	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
THA_RS04880	COG2208	phosphoserine phosphatase activity
THA_RS04880	COG2770	Histidine kinase
THA_RS04885	COG0745	RESPONSE REGULATOR receiver
THA_RS04900	COG1137	ATPase activity
THA_RS04910	COG0513	Belongs to the DEAD box helicase family
THA_RS04915	COG0242	peptide deformylase activity
THA_RS04920	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
THA_RS04930	COG0489	protein tyrosine kinase activity
THA_RS04940	COG0488	(ABC) transporter
THA_RS04945	COG0534	Mate efflux family protein
THA_RS04965	COG0446	pyridine nucleotide-disulphide oxidoreductase
THA_RS04975	COG2226	methyltransferase
THA_RS05010	COG0840	transmembrane signaling receptor activity
THA_RS05015	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
THA_RS05020	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
THA_RS05025	COG0504	CTP synthase activity
THA_RS05030	COG1546	Belongs to the CinA family
THA_RS05030	COG1058	Belongs to the CinA family
THA_RS05035	COG1609	Transcriptional regulator
THA_RS05060	COG1595	DNA-templated transcription, initiation
THA_RS05075	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
THA_RS05080	COG3447	MASE1 domain protein
THA_RS05080	COG5002	protein histidine kinase activity
THA_RS05080	COG5001	Diguanylate cyclase
THA_RS05100	COG0366	Alpha amylase catalytic
THA_RS05105	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
THA_RS05110	COG0840	transmembrane signaling receptor activity
THA_RS05110	COG3290	protein histidine kinase activity
THA_RS05135	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
THA_RS05140	COG0840	transmembrane signaling receptor activity
THA_RS05145	COG4608	Belongs to the ABC transporter superfamily
THA_RS05150	COG0444	Belongs to the ABC transporter superfamily
THA_RS05160	COG0601	transmembrane transport
THA_RS05165	COG0747	negative chemotaxis
THA_RS05175	COG0384	phenazine biosynthesis protein PhzF
THA_RS05180	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
THA_RS05190	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
THA_RS05250	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
THA_RS05260	COG1492	cobalamin metabolic process
THA_RS05265	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
THA_RS05280	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
THA_RS05295	COG2199	diguanylate cyclase activity
THA_RS05315	COG3345	alpha-galactosidase
THA_RS05320	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
THA_RS05335	COG1472	Belongs to the glycosyl hydrolase 3 family
THA_RS05345	COG1175	transmembrane transport
THA_RS05350	COG0395	ABC-type sugar transport system, permease component
THA_RS05365	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
THA_RS05380	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
THA_RS05390	COG2264	protein methyltransferase activity
THA_RS05420	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
THA_RS05425	COG0181	hydroxymethylbilane synthase activity
THA_RS05435	COG0113	porphobilinogen synthase activity
THA_RS05440	COG1648	precorrin-2 dehydrogenase activity
THA_RS05440	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
THA_RS05445	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
THA_RS05450	COG0310	cobalt ion transport
THA_RS05480	COG0328	RNA-DNA hybrid ribonuclease activity
THA_RS05490	COG0518	GMP synthase (glutamine-hydrolyzing) activity
THA_RS05490	COG0519	Catalyzes the synthesis of GMP from XMP
THA_RS05495	COG1704	LemA family
THA_RS05505	COG2801	Transposase and inactivated derivatives
THA_RS05510	COG0778	Nitroreductase
THA_RS05515	COG1410	methionine synthase
THA_RS05515	COG0646	methionine synthase
THA_RS05525	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
THA_RS05540	COG0527	aspartate kinase activity
THA_RS05540	COG0460	homoserine dehydrogenase
THA_RS05570	COG2235	arginine
THA_RS05590	COG5001	Diguanylate cyclase
THA_RS05610	COG0561	phosphatase activity
THA_RS05620	COG0124	histidyl-tRNA synthetase
THA_RS05630	COG1757	Na H antiporter
THA_RS05645	COG1131	(ABC) transporter
THA_RS05660	COG1187	pseudouridine synthase activity
THA_RS05665	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
THA_RS05675	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
THA_RS05680	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
THA_RS05705	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
THA_RS05720	COG2819	hydrolase of the alpha beta superfamily
THA_RS05745	COG0628	permease
THA_RS05775	COG1196	nuclear chromosome segregation
THA_RS05780	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
THA_RS05785	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
THA_RS05790	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
THA_RS05860	COG5012	cobalamin binding
THA_RS05865	COG0084	hydrolase, TatD family'
THA_RS05870	COG0632	four-way junction helicase activity
THA_RS05880	COG2801	Transposase and inactivated derivatives
THA_RS05910	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
THA_RS05920	COG0154	amidase activity
THA_RS05925	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
THA_RS05935	COG0635	Involved in the biosynthesis of porphyrin-containing compound
THA_RS05940	COG0772	Belongs to the SEDS family
THA_RS05950	COG0714	Associated with various cellular activities
THA_RS05965	COG1164	Oligoendopeptidase f
THA_RS05975	COG0101	tRNA pseudouridine synthase activity
THA_RS05985	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
THA_RS05995	COG2198	Histidine kinase
THA_RS05995	COG0643	Histidine kinase
THA_RS06000	COG0835	chemotaxis
THA_RS06005	COG2201	protein-glutamate methylesterase activity
THA_RS06015	COG1338	Plays a role in the flagellum-specific transport system
THA_RS06020	COG1987	bacterial-type flagellum assembly
THA_RS06025	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
THA_RS06030	COG0052	Belongs to the universal ribosomal protein uS2 family
THA_RS06035	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
THA_RS06040	COG0291	Belongs to the bacterial ribosomal protein bL35 family
THA_RS06045	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
THA_RS06065	COG0469	pyruvate kinase activity
THA_RS06080	COG0564	pseudouridine synthase activity
THA_RS06095	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
THA_RS06100	COG0049	tRNA binding
THA_RS06105	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
THA_RS06110	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
THA_RS06115	COG0051	transcription antitermination factor activity, RNA binding
THA_RS06120	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
THA_RS06125	COG0088	Forms part of the polypeptide exit tunnel
THA_RS06130	COG0089	rRNA binding
THA_RS06135	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
THA_RS06140	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
THA_RS06145	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
THA_RS06150	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
THA_RS06155	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
THA_RS06160	COG0255	Belongs to the universal ribosomal protein uL29 family
THA_RS06165	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
THA_RS06170	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
THA_RS06175	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
THA_RS06180	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
THA_RS06185	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
THA_RS06190	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
THA_RS06195	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
THA_RS06200	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
THA_RS06205	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
THA_RS06210	COG1841	ribosomal large subunit assembly
THA_RS06215	COG0200	Binds to the 23S rRNA
THA_RS06220	COG0201	protein transport
THA_RS06225	COG0563	adenylate kinase activity
THA_RS06235	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
THA_RS06240	COG0257	Belongs to the bacterial ribosomal protein bL36 family
THA_RS06245	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
THA_RS06250	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
THA_RS06255	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
THA_RS06260	COG0202	RNA polymerase activity
THA_RS06265	COG0203	ribosomal protein L17
THA_RS06270	COG0544	peptidyl-prolyl cis-trans isomerase activity
THA_RS06275	COG0740	serine-type endopeptidase activity
THA_RS06280	COG0217	transcriptional regulatory protein
THA_RS06290	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
THA_RS06295	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
THA_RS06300	COG0564	pseudouridine synthase activity
THA_RS06305	COG0174	glutamine synthetase
THA_RS06320	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
THA_RS06325	COG1518	maintenance of DNA repeat elements
THA_RS06365	COG2342	PFAM TM1410 hypothetical-related protein
THA_RS06385	COG0438	transferase activity, transferring glycosyl groups
THA_RS06420	COG1214	PFAM Peptidase M22, glycoprotease
THA_RS06425	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
THA_RS06455	COG2078	PFAM AMMECR1 domain protein
THA_RS06480	COG0037	tRNA processing
THA_RS06485	COG3681	Belongs to the UPF0597 family
THA_RS06495	COG1070	Carbohydrate kinase
THA_RS06500	COG1509	lysine 2,3-aminomutase activity
THA_RS06510	COG1609	Transcriptional regulator
THA_RS06515	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
THA_RS06520	COG0395	ABC-type sugar transport system, permease component
THA_RS06525	COG1175	transmembrane transport
THA_RS06575	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
THA_RS06580	COG3481	metal-dependent phosphohydrolase, HD sub domain
THA_RS06585	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
THA_RS06595	COG0227	Belongs to the bacterial ribosomal protein bL28 family
THA_RS06605	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
THA_RS06610	COG0358	DNA primase activity
THA_RS06620	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
THA_RS06625	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
THA_RS06630	COG0211	Belongs to the bacterial ribosomal protein bL27 family
THA_RS06640	COG0261	This protein binds to 23S rRNA in the presence of protein L20
THA_RS06650	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
THA_RS06655	COG2176	DNA-directed DNA polymerase activity
THA_RS06660	COG2359	stage V sporulation protein S
THA_RS06670	COG3872	metal-dependent enzyme
THA_RS06675	COG1131	(ABC) transporter
THA_RS06680	COG0784	Response regulator, receiver
THA_RS06680	COG3437	response regulator, receiver
THA_RS06685	COG0019	diaminopimelate decarboxylase activity
THA_RS06690	COG1473	amidohydrolase
THA_RS06695	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
THA_RS06700	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
THA_RS06705	COG0012	GTP binding
THA_RS06710	COG2052	Domain of unknown function (DUF370)
THA_RS06715	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
THA_RS06720	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
THA_RS06735	COG0546	phosphoglycolate phosphatase activity
THA_RS06745	COG3437	response regulator, receiver
THA_RS06745	COG0784	Response regulator, receiver
THA_RS06750	COG5002	protein histidine kinase activity
THA_RS06755	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
THA_RS06760	COG0438	transferase activity, transferring glycosyl groups
THA_RS06765	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
THA_RS06775	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
THA_RS06780	COG0085	RNA polymerase activity
THA_RS06785	COG0222	ribosome binding
THA_RS06790	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
THA_RS06810	COG0463	Glycosyl transferase, family 2
THA_RS06810	COG0457	Tetratricopeptide repeat
THA_RS06815	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
THA_RS06820	COG0305	Participates in initiation and elongation during chromosome replication
THA_RS06830	COG0251	oxidation-reduction process
THA_RS06840	COG2211	Major facilitator Superfamily
THA_RS06850	COG0561	phosphatase activity
THA_RS06860	COG0017	Asparaginyl-tRNA synthetase
THA_RS06865	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
THA_RS06880	COG1469	GTP cyclohydrolase I activity
THA_RS06895	COG4969	Belongs to the N-Me-Phe pilin family
THA_RS06900	COG1131	(ABC) transporter
THA_RS06920	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
THA_RS06940	COG1376	ErfK ybiS ycfS ynhG family protein
THA_RS06960	COG0785	Cytochrome C biogenesis protein
THA_RS07000	COG1516	flagellar protein fliS
THA_RS07015	COG4608	Belongs to the ABC transporter superfamily
THA_RS07020	COG0444	Belongs to the ABC transporter superfamily
THA_RS07030	COG0601	transmembrane transport
THA_RS07040	COG0742	ribosomal rna small subunit methyltransferase
THA_RS07045	COG1177	transmembrane transport
THA_RS07050	COG1176	ABC-type spermidine putrescine transport system, permease component I
THA_RS07055	COG3842	ATPase activity
THA_RS07060	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
THA_RS07065	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
THA_RS07070	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
THA_RS07080	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
THA_RS07090	COG1811	Na channel or pump
THA_RS07100	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
THA_RS07105	COG1480	7TM receptor with intracellular HD hydrolase
THA_RS07110	COG1702	phosphate starvation-inducible protein PhoH
THA_RS07120	COG1703	isobutyryl-CoA mutase activity
THA_RS07125	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
THA_RS07130	COG4770	biotin carboxylase activity
THA_RS07160	COG0653	protein targeting
THA_RS07165	COG0850	regulation of cytokinetic process
THA_RS07185	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
THA_RS07195	COG1815	bacterial-type flagellum-dependent cell motility
THA_RS07205	COG1677	Flagellar hook-basal body complex protein FliE
THA_RS07215	COG0443	Heat shock 70 kDa protein
THA_RS07220	COG0393	Putative heavy-metal-binding
THA_RS07225	COG1073	alpha beta
THA_RS07250	COG1725	Transcriptional regulator
THA_RS07255	COG0183	Belongs to the thiolase family
THA_RS07265	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
THA_RS07270	COG0493	'glutamate synthase
THA_RS07270	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
THA_RS07275	COG0543	2 iron, 2 sulfur cluster binding
THA_RS07280	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
THA_RS07310	COG2201	protein-glutamate methylesterase activity
THA_RS07350	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
THA_RS07355	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
THA_RS07360	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
THA_RS07365	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
THA_RS07375	COG1418	mRNA catabolic process
THA_RS07395	COG1739	Uncharacterized protein family UPF0029
THA_RS07400	COG0622	Phosphoesterase
THA_RS07405	COG2313	pseudouridylate synthase activity
THA_RS07415	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
THA_RS07420	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
THA_RS07425	COG0047	phosphoribosylformylglycinamidine synthase activity
THA_RS07430	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
THA_RS07435	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
THA_RS07440	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
THA_RS07445	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
THA_RS07450	COG1045	serine acetyltransferase
THA_RS07455	COG0039	L-malate dehydrogenase activity
THA_RS07505	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
THA_RS07510	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
THA_RS07515	COG1073	alpha beta
THA_RS07525	COG2199	diguanylate cyclase activity
THA_RS07525	COG2203	Gaf domain
THA_RS07530	COG0584	glycerophosphoryl diester phosphodiesterase
THA_RS07535	COG0156	8-amino-7-oxononanoate synthase activity
THA_RS07540	COG1063	alcohol dehydrogenase
THA_RS07560	COG0534	Mate efflux family protein
THA_RS07570	COG1131	(ABC) transporter
THA_RS07590	COG1027	Aspartate ammonia-lyase
THA_RS07595	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
THA_RS07605	COG0142	geranyltranstransferase activity
THA_RS07615	COG0572	uridine kinase
THA_RS07620	COG1078	dGTPase activity
THA_RS07625	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
THA_RS07650	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
THA_RS07655	COG1660	Displays ATPase and GTPase activities
THA_RS07660	COG0391	Required for morphogenesis under gluconeogenic growth conditions
THA_RS07670	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
THA_RS07675	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
THA_RS07680	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
THA_RS07690	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
THA_RS07700	COG1132	(ABC) transporter
THA_RS07710	COG0444	Belongs to the ABC transporter superfamily
THA_RS07715	COG4608	Belongs to the ABC transporter superfamily
THA_RS07720	COG0747	negative chemotaxis
THA_RS07725	COG0601	transmembrane transport
THA_RS07730	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
THA_RS07790	COG0640	Transcriptional regulator
THA_RS07795	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
THA_RS07800	COG3842	ATPase activity
THA_RS07815	COG1309	transcriptional regulator
THA_RS07820	COG0254	rRNA binding
THA_RS07835	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
THA_RS07865	COG0483	inositol monophosphate 1-phosphatase activity
THA_RS07875	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
THA_RS07885	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
THA_RS07895	COG1610	YqeY-like protein
THA_RS07900	COG0698	ribose 5-phosphate isomerase
THA_RS07905	COG1366	Belongs to the anti-sigma-factor antagonist family
THA_RS07910	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
THA_RS07920	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
THA_RS07925	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
THA_RS07925	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
THA_RS07950	COG3250	beta-galactosidase activity
THA_RS07960	COG1085	galactose-1-phosphate uridylyltransferase
THA_RS07965	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
THA_RS07970	COG0540	Belongs to the ATCase OTCase family
THA_RS07970	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
THA_RS07980	COG0735	belongs to the Fur family
THA_RS07985	COG0450	alkyl hydroperoxide reductase
THA_RS08005	COG2033	superoxide reductase activity
THA_RS08015	COG4964	Belongs to the GSP D family
THA_RS08060	COG0720	synthase
THA_RS08080	COG0745	RESPONSE REGULATOR receiver
THA_RS08085	COG0149	triose-phosphate isomerase activity
THA_RS08085	COG0126	phosphoglycerate kinase activity
THA_RS08090	COG0126	phosphoglycerate kinase activity
THA_RS08095	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
THA_RS08110	COG1157	protein secretion by the type III secretion system
THA_RS08120	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
THA_RS08125	COG0191	fructose-bisphosphate aldolase activity
THA_RS08140	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
THA_RS08155	COG0233	cytoplasmic translational termination
THA_RS08160	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
THA_RS08165	COG0575	Belongs to the CDS family
THA_RS08170	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
THA_RS08175	COG1077	Cell shape determining protein MreB Mrl
THA_RS08190	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
THA_RS08210	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
THA_RS08230	COG1749	Flagellar hook protein flgE
THA_RS08235	COG1582	Flagellar protein (FlbD)
THA_RS08245	COG1360	Flagellar Motor Protein
THA_RS08255	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
THA_RS08260	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
THA_RS08260	COG1776	CheC inhibitor of MCP methylation
THA_RS08265	COG2801	Transposase and inactivated derivatives
THA_RS08275	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
THA_RS08285	COG2239	Acts as a magnesium transporter
THA_RS08295	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
THA_RS08300	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
THA_RS08305	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
THA_RS08315	COG1120	ATPase activity
THA_RS08330	COG2172	sigma factor antagonist activity
THA_RS08335	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
THA_RS08340	COG1490	D-aminoacyl-tRNA deacylase activity
THA_RS08345	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
THA_RS08370	COG2080	2 iron, 2 sulfur cluster binding
THA_RS08370	COG1529	Aldehyde oxidase and xanthine dehydrogenase
THA_RS08375	COG2080	2 iron, 2 sulfur cluster binding
THA_RS08395	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
THA_RS08410	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
THA_RS08435	COG3314	Sporulation integral membrane protein YlbJ
THA_RS08440	COG0019	diaminopimelate decarboxylase activity
THA_RS08455	COG0357	Ribosomal RNA small subunit methyltransferase G
THA_RS08460	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
THA_RS08485	COG0493	'glutamate synthase
THA_RS08490	COG0649	NAD binding
THA_RS08495	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
THA_RS08500	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
THA_RS08505	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
THA_RS08510	COG0651	ATP synthesis coupled electron transport
THA_RS08515	COG0651	ATP synthesis coupled electron transport
THA_RS08520	COG1006	Multisubunit Na H antiporter MnhC subunit
THA_RS08525	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
THA_RS08525	COG2111	Na H antiporter
THA_RS08540	COG2212	antiporter activity
THA_RS08545	COG1863	multisubunit Na H antiporter MnhE subunit
THA_RS08550	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
THA_RS08560	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
THA_RS08570	COG0737	Belongs to the 5'-nucleotidase family
THA_RS08575	COG1435	thymidine kinase activity
THA_RS08580	COG2770	Histidine kinase
THA_RS08580	COG3437	response regulator, receiver
THA_RS08610	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
THA_RS08615	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
THA_RS08620	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
THA_RS08630	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
THA_RS08635	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
THA_RS08650	COG1752	Esterase of the alpha-beta hydrolase superfamily
THA_RS08655	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
THA_RS08665	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
THA_RS08665	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
THA_RS08685	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
THA_RS08690	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
THA_RS08695	COG0658	competence protein
THA_RS08700	COG0735	belongs to the Fur family
THA_RS08705	COG0195	Participates in both transcription termination and antitermination
THA_RS08710	COG0779	Required for maturation of 30S ribosomal subunits
THA_RS08735	COG0343	queuine tRNA-ribosyltransferase activity
THA_RS08750	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
THA_RS08755	COG2151	metal-sulfur cluster biosynthetic enzyme
THA_RS08760	COG2890	protein-(glutamine-N5) methyltransferase activity
THA_RS08765	COG0359	binds to the 23S rRNA
THA_RS08780	COG0617	tRNA 3'-terminal CCA addition
THA_RS08780	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
THA_RS08780	COG3620	sequence-specific DNA binding
THA_RS08815	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
THA_RS08820	COG1776	CheC inhibitor of MCP methylation
THA_RS08840	COG1419	protein localization to endoplasmic reticulum
THA_RS08845	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
THA_RS08885	COG0628	permease
THA_RS08890	COG3956	TIGRFAM MazG family protein
THA_RS08895	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
THA_RS08900	COG0745	RESPONSE REGULATOR receiver
THA_RS08905	COG2738	Putative neutral zinc metallopeptidase
THA_RS08915	COG0557	exoribonuclease II activity
THA_RS08925	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
THA_RS08935	COG0497	DNA recombination
THA_RS08940	COG0295	cytidine deaminase activity
THA_RS08950	COG1032	radical SAM domain protein
THA_RS08955	COG1162	GTPase activity
THA_RS08965	COG0820	rRNA (adenine-C2-)-methyltransferase activity
THA_RS08970	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
THA_RS08980	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
THA_RS08985	COG1639	'signal transduction protein
THA_RS08990	COG5002	protein histidine kinase activity
THA_RS09000	COG0218	Necessary for normal cell division and for the maintenance of normal septation
THA_RS09005	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
THA_RS09010	COG0802	atpase or kinase
THA_RS09015	COG1774	PSP1 C-terminal conserved region
THA_RS09020	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
THA_RS09025	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
THA_RS09035	COG1268	BioY protein
THA_RS09040	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
THA_RS09050	COG1635	Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur
THA_RS09055	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
THA_RS09065	COG1992	Thiamine-phosphate synthase
THA_RS09065	COG0351	phosphomethylpyrimidine kinase
THA_RS09070	COG0205	6-phosphofructokinase activity
THA_RS09075	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
THA_RS09080	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
THA_RS09115	COG0571	ribonuclease III activity
THA_RS09120	COG0519	Catalyzes the synthesis of GMP from XMP
THA_RS09120	COG0518	GMP synthase (glutamine-hydrolyzing) activity
THA_RS09125	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
THA_RS09125	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
THA_RS09130	COG0728	peptidoglycan biosynthetic process
THA_RS09135	COG2878	Part of a membrane complex involved in electron transport
THA_RS09140	COG0758	DNA mediated transformation
THA_RS09145	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
THA_RS09155	COG1185	polyribonucleotide nucleotidyltransferase activity
THA_RS09160	COG0612	Peptidase, M16
THA_RS09170	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
THA_RS09175	COG1175	transmembrane transport
THA_RS09180	COG0395	ABC-type sugar transport system, permease component
THA_RS09185	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
THA_RS09190	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
THA_RS09195	COG1366	Belongs to the anti-sigma-factor antagonist family
THA_RS09200	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
THA_RS09205	COG0539	negative regulation of cytoplasmic translation
THA_RS09205	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
THA_RS09210	COG1160	GTP binding
THA_RS09215	COG3547	Transposase (IS116 IS110 IS902 family)
THA_RS09220	COG1744	ABC transporter substrate-binding protein PnrA-like
THA_RS09235	COG0230	Belongs to the bacterial ribosomal protein bL34 family
THA_RS09240	COG0594	ribonuclease P activity
THA_RS09245	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
THA_RS09250	COG0706	membrane insertase activity
THA_RS09275	COG0174	glutamine synthetase
THA_RS09280	COG2203	Gaf domain
THA_RS09280	COG2199	diguanylate cyclase activity
THA_RS09305	COG1132	(ABC) transporter
THA_RS09355	COG0587	DNA-directed DNA polymerase activity
THA_RS09360	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
THA_RS09365	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
THA_RS09370	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
THA_RS09375	COG3706	GGDEF domain
THA_RS09380	COG0812	UDP-N-acetylmuramate dehydrogenase activity
THA_RS09385	COG1362	aminopeptidase activity
THA_RS09410	COG1482	cell wall glycoprotein biosynthetic process
THA_RS09420	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
THA_RS09425	COG2255	four-way junction helicase activity
THA_RS09430	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
THA_RS09440	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
THA_RS09445	COG0704	Plays a role in the regulation of phosphate uptake
THA_RS09455	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
THA_RS09460	COG0138	bifunctional purine biosynthesis protein purh
THA_RS09480	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
THA_RS09485	COG2894	cell division
THA_RS09510	COG0552	protein localization to endoplasmic reticulum
THA_RS09520	COG3584	3D domain protein
THA_RS09520	COG1388	LysM domain
THA_RS09530	COG0482	sulfurtransferase activity
THA_RS09535	COG0037	tRNA processing
THA_RS09535	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
THA_RS09540	COG1316	TRANSCRIPTIONal
THA_RS09545	COG1515	deoxyribonuclease V activity
THA_RS09555	COG1242	4 iron, 4 sulfur cluster binding
THA_RS09560	COG0402	S-adenosylhomocysteine deaminase activity
THA_RS09565	COG0799	negative regulation of ribosome biogenesis
THA_RS09575	COG0525	valine-tRNA ligase activity
THA_RS09585	COG4656	Part of a membrane complex involved in electron transport
THA_RS09590	COG4658	electron transport chain
THA_RS09600	COG4660	Part of a membrane complex involved in electron transport
THA_RS09605	COG4657	Part of a membrane complex involved in electron transport
THA_RS09630	COG0517	IMP dehydrogenase activity
THA_RS09630	COG0516	GMP reductase activity
THA_RS09640	COG0840	transmembrane signaling receptor activity
THA_RS09645	COG1028	Short-chain dehydrogenase reductase Sdr
THA_RS09650	COG0366	Alpha amylase catalytic
THA_RS09655	COG2226	methyltransferase
THA_RS09665	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
THA_RS09670	COG1151	hydroxylamine reductase activity
THA_RS09680	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
THA_RS09685	COG0157	Belongs to the NadC ModD family
THA_RS09690	COG3706	GGDEF domain
THA_RS09700	COG2723	6-phospho-beta-galactosidase activity
THA_RS09705	COG0730	response to heat
THA_RS09715	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
THA_RS09730	COG1175	transmembrane transport
THA_RS09755	COG0395	ABC-type sugar transport system, permease component
THA_RS09775	COG4989	oxidoreductase activity
THA_RS09785	COG1472	Belongs to the glycosyl hydrolase 3 family
THA_RS09795	COG4948	Mandelate Racemase Muconate Lactonizing
THA_RS09805	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
THA_RS09810	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
THA_RS09815	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
THA_RS09820	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
THA_RS09825	COG1518	maintenance of DNA repeat elements
THA_RS09860	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
THA_RS09880	COG3547	Transposase (IS116 IS110 IS902 family)
THA_RS09885	COG1609	Transcriptional regulator
THA_RS09890	COG1175	transmembrane transport
THA_RS09895	COG0395	ABC-type sugar transport system, permease component
THA_RS09905	COG1486	melibiose metabolic process
THA_RS09915	COG1028	Short-chain dehydrogenase reductase Sdr
THA_RS09925	COG0798	PFAM Bile acid sodium symporter
THA_RS09935	COG0300	oxidoreductase activity
THA_RS09945	COG1013	pyruvate-flavodoxin oxidoreductase activity
THA_RS10000	COG3842	ATPase activity
THA_RS10005	COG0438	transferase activity, transferring glycosyl groups
THA_RS10010	COG1737	Transcriptional regulator
THA_RS10025	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
THA_RS10050	COG2189	Belongs to the N(4) N(6)-methyltransferase family
THA_RS10060	COG0045	succinate-CoA ligase (ADP-forming) activity
THA_RS10070	COG0045	succinate-CoA ligase (ADP-forming) activity
THA_RS10080	COG2217	Heavy metal translocating P-type atpase
THA_RS10115	COG4124	Belongs to the glycosyl hydrolase 26 family
THA_RS10115	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
THA_RS10120	COG4124	Belongs to the glycosyl hydrolase 26 family
THA_RS10120	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
THA_RS10150	COG0514	ATP-dependent DNA helicase (RecQ)