locus-tag	class	description
BW47_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
BW47_RS00010	COG1141	Ferredoxin
BW47_RS00015	COG1132	(ABC) transporter
BW47_RS00025	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
BW47_RS00040	COG1132	(ABC) transporter
BW47_RS00060	COG1131	(ABC) transporter
BW47_RS00070	COG1902	pentaerythritol trinitrate reductase activity
BW47_RS00070	COG0446	pyridine nucleotide-disulphide oxidoreductase
BW47_RS00100	COG1012	belongs to the aldehyde dehydrogenase family
BW47_RS00110	COG1744	ABC transporter substrate-binding protein PnrA-like
BW47_RS00115	COG3845	ABC transporter
BW47_RS00120	COG4603	Belongs to the binding-protein-dependent transport system permease family
BW47_RS00125	COG1079	Belongs to the binding-protein-dependent transport system permease family
BW47_RS00140	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
BW47_RS00145	COG1307	EDD domain protein, DegV family
BW47_RS00150	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
BW47_RS00155	COG0542	response to heat
BW47_RS00190	COG0492	ferredoxin-NADP+ reductase activity
BW47_RS00195	COG1335	isochorismatase
BW47_RS00200	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
BW47_RS00205	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
BW47_RS00215	COG1564	THIamine pyrophosphokinase
BW47_RS00220	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
BW47_RS00225	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
BW47_RS00230	COG4139	cobalamin transport
BW47_RS00240	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
BW47_RS00255	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
BW47_RS00260	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
BW47_RS00260	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
BW47_RS00265	COG0307	riboflavin synthase, alpha
BW47_RS00270	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BW47_RS00270	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BW47_RS00275	COG0840	transmembrane signaling receptor activity
BW47_RS00280	COG0822	iron-sulfur transferase activity
BW47_RS00285	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
BW47_RS00295	COG0719	Fe-S assembly protein
BW47_RS00305	COG0459	protein refolding
BW47_RS00310	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
BW47_RS00330	COG0312	modulator of DNA gyrase
BW47_RS00335	COG0312	modulator of DNA gyrase
BW47_RS00350	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
BW47_RS00355	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
BW47_RS00360	COG0442	prolyl-tRNA aminoacylation
BW47_RS00365	COG0215	cysteine-tRNA ligase activity
BW47_RS00370	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
BW47_RS00390	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
BW47_RS00395	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
BW47_RS00400	COG1335	isochorismatase
BW47_RS00405	COG1230	cation diffusion facilitator family transporter
BW47_RS00420	COG0297	glycogen (starch) synthase activity
BW47_RS00430	COG3829	transcription factor binding
BW47_RS00430	COG3290	protein histidine kinase activity
BW47_RS00440	COG1181	Belongs to the D-alanine--D-alanine ligase family
BW47_RS00455	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BW47_RS00460	COG2379	hydroxypyruvate reductase
BW47_RS00465	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
BW47_RS00470	COG0484	heat shock protein binding
BW47_RS00475	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
BW47_RS00485	COG0477	Major facilitator Superfamily
BW47_RS00490	COG1827	regulation of RNA biosynthetic process
BW47_RS00495	COG1272	protein, Hemolysin III
BW47_RS00500	COG1047	Peptidyl-prolyl cis-trans
BW47_RS00510	COG0535	radical SAM domain protein
BW47_RS00515	COG1363	Peptidase, m42
BW47_RS00525	COG1758	RNA polymerase activity
BW47_RS00530	COG0194	GDP metabolic process
BW47_RS00535	COG2052	Domain of unknown function (DUF370)
BW47_RS00570	COG3426	butyrate kinase activity
BW47_RS00575	COG0280	phosphate acetyltransferase
BW47_RS00580	COG3426	butyrate kinase activity
BW47_RS00585	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BW47_RS00595	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
BW47_RS00600	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BW47_RS00605	COG1966	Carbon starvation protein
BW47_RS00610	COG3279	Response regulator of the LytR AlgR family
BW47_RS00615	COG3275	phosphorelay sensor kinase activity
BW47_RS00630	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BW47_RS00635	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
BW47_RS00640	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
BW47_RS00645	COG0402	S-adenosylhomocysteine deaminase activity
BW47_RS00650	COG0167	dihydroorotate dehydrogenase activity
BW47_RS00680	COG2359	stage V sporulation protein S
BW47_RS00685	COG0737	Belongs to the 5'-nucleotidase family
BW47_RS00690	COG1132	(ABC) transporter
BW47_RS00720	COG0301	tRNA thio-modification
BW47_RS00735	COG1132	(ABC) transporter
BW47_RS00745	COG1846	Transcriptional regulator
BW47_RS00750	COG2373	Large extracellular alpha-helical protein
BW47_RS00760	COG3234	Protein of unknown function (DUF1175)
BW47_RS00775	COG0446	pyridine nucleotide-disulphide oxidoreductase
BW47_RS00790	COG0840	transmembrane signaling receptor activity
BW47_RS00805	COG0534	Mate efflux family protein
BW47_RS00810	COG0667	Aldo Keto reductase
BW47_RS00825	COG1131	(ABC) transporter
BW47_RS00835	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
BW47_RS00835	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
BW47_RS00840	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
BW47_RS00840	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
BW47_RS00845	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BW47_RS00855	COG1573	uracil-dna glycosylase
BW47_RS00860	COG0574	Belongs to the PEP-utilizing enzyme family
BW47_RS00860	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
BW47_RS00870	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
BW47_RS00875	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
BW47_RS00880	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
BW47_RS00885	COG0193	aminoacyl-tRNA hydrolase activity
BW47_RS00905	COG0529	Catalyzes the synthesis of activated sulfate
BW47_RS00910	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
BW47_RS00915	COG4974	Belongs to the 'phage' integrase family
BW47_RS00940	COG0148	phosphopyruvate hydratase activity
BW47_RS00950	COG3206	protein involved in exopolysaccharide biosynthesis
BW47_RS00955	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
BW47_RS00965	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
BW47_RS00970	COG0116	Belongs to the methyltransferase superfamily
BW47_RS00975	COG1993	acr, cog1993
BW47_RS00980	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
BW47_RS00990	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
BW47_RS00995	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
BW47_RS01005	COG2264	protein methyltransferase activity
BW47_RS01010	COG0739	heme binding
BW47_RS01015	COG1607	acyl-coa hydrolase
BW47_RS01020	COG3246	L-lysine catabolic process to acetate
BW47_RS01025	COG0604	alcohol dehydrogenase
BW47_RS01030	COG1509	lysine 2,3-aminomutase activity
BW47_RS01035	COG2030	dehydratase
BW47_RS01050	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
BW47_RS01055	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
BW47_RS01070	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
BW47_RS01085	COG0667	Aldo Keto reductase
BW47_RS01090	COG1472	Belongs to the glycosyl hydrolase 3 family
BW47_RS01115	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
BW47_RS01120	COG0037	tRNA processing
BW47_RS01135	COG1968	undecaprenyl-diphosphatase activity
BW47_RS01140	COG1228	amidohydrolase
BW47_RS01155	COG0424	maF-like protein
BW47_RS01160	COG2003	Belongs to the UPF0758 family
BW47_RS01175	COG1215	transferase activity, transferring glycosyl groups
BW47_RS01180	COG1442	glycosyl transferase family 8
BW47_RS01180	COG1216	Glycosyl transferase, family 2
BW47_RS01205	COG0793	Belongs to the peptidase S41A family
BW47_RS01210	COG2226	methyltransferase
BW47_RS01225	COG1713	HD superfamily hydrolase involved in NAD metabolism
BW47_RS01235	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
BW47_RS01240	COG0009	L-threonylcarbamoyladenylate synthase
BW47_RS01250	COG0481	GTPase activity
BW47_RS01255	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
BW47_RS01260	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
BW47_RS01265	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
BW47_RS01270	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
BW47_RS01280	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
BW47_RS01290	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
BW47_RS01295	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
BW47_RS01305	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
BW47_RS01310	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
BW47_RS01315	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
BW47_RS01320	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
BW47_RS01335	COG1461	Dihydroxyacetone kinase
BW47_RS01345	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
BW47_RS01350	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
BW47_RS01355	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
BW47_RS01365	COG0495	leucyl-tRNA aminoacylation
BW47_RS01385	COG0750	zinc metalloprotease
BW47_RS01400	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
BW47_RS01410	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
BW47_RS01415	COG0543	2 iron, 2 sulfur cluster binding
BW47_RS01420	COG0167	dihydroorotate dehydrogenase activity
BW47_RS01425	COG0284	orotidine-5'-phosphate decarboxylase activity
BW47_RS01430	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
BW47_RS01455	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BW47_RS01470	COG2183	response to ionizing radiation
BW47_RS01475	COG0835	chemotaxis
BW47_RS01480	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
BW47_RS01490	COG1278	Cold shock
BW47_RS01495	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
BW47_RS01500	COG0095	Lipoate-protein ligase
BW47_RS01520	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
BW47_RS01525	COG5002	protein histidine kinase activity
BW47_RS01530	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
BW47_RS01540	COG1307	EDD domain protein, DegV family
BW47_RS01545	COG0355	proton-transporting ATP synthase activity, rotational mechanism
BW47_RS01550	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
BW47_RS01555	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
BW47_RS01560	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
BW47_RS01565	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
BW47_RS01570	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
BW47_RS01575	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
BW47_RS01595	COG0006	proline dipeptidase activity
BW47_RS01605	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
BW47_RS01610	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
BW47_RS01610	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
BW47_RS01620	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
BW47_RS01625	COG5002	protein histidine kinase activity
BW47_RS01630	COG2759	Belongs to the formate--tetrahydrofolate ligase family
BW47_RS01635	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
BW47_RS01655	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
BW47_RS01665	COG0537	adenosine 5'-monophosphoramidase activity
BW47_RS01670	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
BW47_RS01680	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
BW47_RS01690	COG4112	unkown
BW47_RS01695	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
BW47_RS01700	COG1067	ATP-dependent peptidase activity
BW47_RS01705	COG0180	Tryptophanyl-tRNA synthetase
BW47_RS01710	COG0668	transmembrane transport
BW47_RS01715	COG0840	transmembrane signaling receptor activity
BW47_RS01740	COG1256	bacterial-type flagellum assembly
BW47_RS01740	COG1256	bacterial-type flagellum assembly
BW47_RS01740	COG4786	Flagellar basal body rod
BW47_RS01740	COG4786	Flagellar basal body rod
BW47_RS01790	COG1760	l-serine dehydratase
BW47_RS01800	COG1543	Belongs to the glycosyl hydrolase 57 family
BW47_RS01805	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
BW47_RS01810	COG1144	Oxidoreductase
BW47_RS01815	COG0674	pyruvate-flavodoxin oxidoreductase activity
BW47_RS01820	COG1013	pyruvate-flavodoxin oxidoreductase activity
BW47_RS01825	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
BW47_RS01860	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
BW47_RS01865	COG1518	maintenance of DNA repeat elements
BW47_RS01920	COG0501	Belongs to the peptidase M48B family
BW47_RS01925	COG0110	maltose O-acetyltransferase activity
BW47_RS01945	COG0438	transferase activity, transferring glycosyl groups
BW47_RS01960	COG0514	ATP-dependent DNA helicase (RecQ)
BW47_RS01990	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
BW47_RS01995	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
BW47_RS02010	COG0436	Aminotransferase
BW47_RS02015	COG2045	Belongs to the ComB family
BW47_RS02025	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
BW47_RS02035	COG0105	UTP biosynthetic process
BW47_RS02045	COG3864	Putative metallopeptidase domain
BW47_RS02060	COG0151	Belongs to the GarS family
BW47_RS02065	COG0138	bifunctional purine biosynthesis protein purh
BW47_RS02070	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
BW47_RS02075	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
BW47_RS02105	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
BW47_RS02140	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
BW47_RS02165	COG4555	ABC transporter
BW47_RS02170	COG0842	Transport permease protein
BW47_RS02175	COG3409	Peptidoglycan-binding domain 1 protein
BW47_RS02175	COG0793	Belongs to the peptidase S41A family
BW47_RS02200	COG0542	response to heat
BW47_RS02205	COG1773	rubredoxin
BW47_RS02220	COG1187	pseudouridine synthase activity
BW47_RS02225	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
BW47_RS02230	COG1074	ATP-dependent DNA helicase activity
BW47_RS02250	COG3345	alpha-galactosidase
BW47_RS02255	COG1085	galactose-1-phosphate uridylyltransferase
BW47_RS02260	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
BW47_RS02275	COG0776	regulation of translation
BW47_RS02280	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
BW47_RS02285	COG0432	Pfam Uncharacterised protein family UPF0047
BW47_RS02295	COG0803	Belongs to the bacterial solute-binding protein 9 family
BW47_RS02300	COG1121	(ABC) transporter
BW47_RS02305	COG1108	ABC-type Mn2 Zn2 transport systems permease components
BW47_RS02315	COG0196	riboflavin kinase activity
BW47_RS02320	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
BW47_RS02335	COG2252	PERMEase
BW47_RS02390	COG1131	(ABC) transporter
BW47_RS02415	COG1523	belongs to the glycosyl hydrolase 13 family
BW47_RS02420	COG0745	RESPONSE REGULATOR receiver
BW47_RS02425	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
BW47_RS02435	COG0697	spore germination
BW47_RS02440	COG1077	Cell shape determining protein MreB Mrl
BW47_RS02465	COG0765	amino acid transport
BW47_RS02470	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BW47_RS02475	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
BW47_RS02480	COG0416	fatty acid biosynthetic process
BW47_RS02485	COG0333	Belongs to the bacterial ribosomal protein bL32 family
BW47_RS02500	COG1766	The M ring may be actively involved in energy transduction
BW47_RS02505	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
BW47_RS02510	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
BW47_RS02515	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
BW47_RS02530	COG0528	UMP kinase activity
BW47_RS02535	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
BW47_RS02540	COG1406	Chemotaxis phosphatase CheX
BW47_RS02545	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
BW47_RS02550	COG1181	Belongs to the D-alanine--D-alanine ligase family
BW47_RS02555	COG2267	carboxylic ester hydrolase activity
BW47_RS02560	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
BW47_RS02580	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
BW47_RS02595	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
BW47_RS02605	COG3437	response regulator, receiver
BW47_RS02605	COG0784	Response regulator, receiver
BW47_RS02610	COG3852	Histidine kinase
BW47_RS02625	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
BW47_RS02630	COG0085	RNA polymerase activity
BW47_RS02635	COG0222	ribosome binding
BW47_RS02640	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
BW47_RS02655	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
BW47_RS02660	COG0367	asparagine synthase
BW47_RS02665	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
BW47_RS02675	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
BW47_RS02695	COG0457	Tetratricopeptide repeat
BW47_RS02695	COG0463	Glycosyl transferase, family 2
BW47_RS02700	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
BW47_RS02705	COG0305	Participates in initiation and elongation during chromosome replication
BW47_RS02725	COG0251	oxidation-reduction process
BW47_RS02735	COG2211	Major facilitator Superfamily
BW47_RS02740	COG1803	Methylglyoxal synthase
BW47_RS02745	COG0561	phosphatase activity
BW47_RS02755	COG0017	Asparaginyl-tRNA synthetase
BW47_RS02760	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
BW47_RS02775	COG1469	GTP cyclohydrolase I activity
BW47_RS02785	COG0438	transferase activity, transferring glycosyl groups
BW47_RS02790	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BW47_RS02795	COG0592	DNA-directed DNA polymerase activity
BW47_RS02830	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
BW47_RS02850	COG1376	ErfK ybiS ycfS ynhG family protein
BW47_RS02870	COG0785	Cytochrome C biogenesis protein
BW47_RS02910	COG1516	flagellar protein fliS
BW47_RS02925	COG4608	Belongs to the ABC transporter superfamily
BW47_RS02930	COG0444	Belongs to the ABC transporter superfamily
BW47_RS02940	COG0601	transmembrane transport
BW47_RS02945	COG4166	transmembrane transport
BW47_RS02950	COG0742	ribosomal rna small subunit methyltransferase
BW47_RS02955	COG1177	transmembrane transport
BW47_RS02965	COG3842	ATPase activity
BW47_RS02970	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
BW47_RS02975	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
BW47_RS02980	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
BW47_RS02990	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BW47_RS03000	COG1811	Na channel or pump
BW47_RS03010	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
BW47_RS03015	COG1480	7TM receptor with intracellular HD hydrolase
BW47_RS03035	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
BW47_RS03040	COG0511	ligase activity, forming carbon-carbon bonds
BW47_RS03055	COG0346	lactoylglutathione lyase activity
BW47_RS03070	COG0653	protein targeting
BW47_RS03095	COG3833	ABC-type maltose transport systems, permease component
BW47_RS03100	COG1175	transmembrane transport
BW47_RS03110	COG0542	response to heat
BW47_RS03115	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
BW47_RS03130	COG0719	Fe-S assembly protein
BW47_RS03140	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
BW47_RS03185	COG1328	CTP reductase activity
BW47_RS03205	COG1609	Transcriptional regulator
BW47_RS03245	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
BW47_RS03260	COG0446	pyridine nucleotide-disulphide oxidoreductase
BW47_RS03270	COG2199	diguanylate cyclase activity
BW47_RS03270	COG2203	Gaf domain
BW47_RS03275	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
BW47_RS03300	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
BW47_RS03305	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
BW47_RS03310	COG0517	IMP dehydrogenase activity
BW47_RS03310	COG0516	GMP reductase activity
BW47_RS03320	COG0330	HflC and HflK could
BW47_RS03325	COG1592	Rubrerythrin
BW47_RS03330	COG0751	glycine-tRNA ligase activity
BW47_RS03335	COG0752	glycyl-tRNA synthetase alpha subunit
BW47_RS03345	COG0772	Belongs to the SEDS family
BW47_RS03360	COG0360	Binds together with S18 to 16S ribosomal RNA
BW47_RS03365	COG0629	single-stranded DNA binding
BW47_RS03370	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
BW47_RS03385	COG0267	Belongs to the bacterial ribosomal protein bL33 family
BW47_RS03395	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
BW47_RS03400	COG0250	Participates in transcription elongation, termination and antitermination
BW47_RS03405	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
BW47_RS03410	COG0081	regulation of translation
BW47_RS03440	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
BW47_RS03455	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
BW47_RS03465	COG4659	FMN binding
BW47_RS03475	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
BW47_RS03475	COG0662	Cupin 2, conserved barrel domain protein
BW47_RS03480	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
BW47_RS03485	COG2086	electron transfer activity
BW47_RS03490	COG1960	acyl-CoA dehydrogenase activity
BW47_RS03525	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
BW47_RS03535	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
BW47_RS03540	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
BW47_RS03550	COG1706	bacterial-type flagellum-dependent cell motility
BW47_RS03555	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
BW47_RS03565	COG0187	DNA topoisomerase II activity
BW47_RS03575	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
BW47_RS03580	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
BW47_RS03585	COG0516	GMP reductase activity
BW47_RS03585	COG0517	IMP dehydrogenase activity
BW47_RS03595	COG1132	(ABC) transporter
BW47_RS03620	COG2217	Heavy metal translocating P-type atpase
BW47_RS03640	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
BW47_RS03655	COG1472	Belongs to the glycosyl hydrolase 3 family
BW47_RS03665	COG1175	transmembrane transport
BW47_RS03670	COG0395	ABC-type sugar transport system, permease component
BW47_RS03685	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
BW47_RS03700	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
BW47_RS03740	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
BW47_RS03745	COG0181	hydroxymethylbilane synthase activity
BW47_RS03755	COG0113	porphobilinogen synthase activity
BW47_RS03765	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
BW47_RS03770	COG0310	cobalt ion transport
BW47_RS03785	COG1122	ATPase activity
BW47_RS03800	COG0518	GMP synthase (glutamine-hydrolyzing) activity
BW47_RS03800	COG0519	Catalyzes the synthesis of GMP from XMP
BW47_RS03805	COG1704	LemA family
BW47_RS03825	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
BW47_RS03830	COG0306	phosphate transporter
BW47_RS03845	COG1410	methionine synthase
BW47_RS03845	COG0646	methionine synthase
BW47_RS03855	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
BW47_RS03870	COG0460	homoserine dehydrogenase
BW47_RS03870	COG0527	aspartate kinase activity
BW47_RS03880	COG0366	Alpha amylase catalytic
BW47_RS03890	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
BW47_RS03900	COG1131	(ABC) transporter
BW47_RS03910	COG4565	transcriptional regulatory protein
BW47_RS03920	COG0124	histidyl-tRNA synthetase
BW47_RS03945	COG0840	transmembrane signaling receptor activity
BW47_RS03950	COG3300	MHYT domain
BW47_RS03950	COG5001	Diguanylate cyclase
BW47_RS03955	COG0395	ABC-type sugar transport system, permease component
BW47_RS03970	COG1151	hydroxylamine reductase activity
BW47_RS03985	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BW47_RS04000	COG0384	phenazine biosynthesis protein PhzF
BW47_RS04005	COG4948	Mandelate Racemase Muconate Lactonizing
BW47_RS04010	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
BW47_RS04025	COG1486	melibiose metabolic process
BW47_RS04045	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
BW47_RS04050	COG0366	Alpha amylase catalytic
BW47_RS04065	COG3706	GGDEF domain
BW47_RS04070	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
BW47_RS04085	COG1595	DNA-templated transcription, initiation
BW47_RS04115	COG1546	Belongs to the CinA family
BW47_RS04115	COG1058	Belongs to the CinA family
BW47_RS04120	COG0504	CTP synthase activity
BW47_RS04125	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
BW47_RS04130	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
BW47_RS04140	COG1392	Phosphate transport regulator
BW47_RS04145	COG0306	phosphate transporter
BW47_RS04150	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
BW47_RS04180	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
BW47_RS04185	COG4869	propanediol catabolic process
BW47_RS04205	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
BW47_RS04215	COG1006	Multisubunit Na H antiporter MnhC subunit
BW47_RS04220	COG0651	ATP synthesis coupled electron transport
BW47_RS04225	COG0205	6-phosphofructokinase activity
BW47_RS04230	COG1979	alcohol dehydrogenase
BW47_RS04235	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
BW47_RS04240	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BW47_RS04240	COG0072	phenylalanine-tRNA ligase activity
BW47_RS04260	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
BW47_RS04270	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
BW47_RS04290	COG1175	transmembrane transport
BW47_RS04295	COG0395	ABC-type sugar transport system, permease component
BW47_RS04300	COG0840	transmembrane signaling receptor activity
BW47_RS04305	COG3706	GGDEF domain
BW47_RS04310	COG3706	GGDEF domain
BW47_RS04315	COG4399	Belongs to the UPF0754 family
BW47_RS04320	COG0445	tRNA wobble uridine modification
BW47_RS04325	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BW47_RS04330	COG1489	DNA binding
BW47_RS04345	COG0640	Transcriptional regulator
BW47_RS04350	COG0534	Mate efflux family protein
BW47_RS04355	COG0488	(ABC) transporter
BW47_RS04375	COG0489	protein tyrosine kinase activity
BW47_RS04385	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
BW47_RS04390	COG0242	peptide deformylase activity
BW47_RS04395	COG0513	Belongs to the DEAD box helicase family
BW47_RS04405	COG1137	ATPase activity
BW47_RS04420	COG0745	RESPONSE REGULATOR receiver
BW47_RS04430	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
BW47_RS04440	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
BW47_RS04455	COG1684	flagellar biosynthetic protein fliR
BW47_RS04465	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
BW47_RS04470	COG2199	diguanylate cyclase activity
BW47_RS04470	COG2203	Gaf domain
BW47_RS04485	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
BW47_RS04495	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
BW47_RS04510	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
BW47_RS04545	COG1187	pseudouridine synthase activity
BW47_RS04550	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
BW47_RS04560	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
BW47_RS04565	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
BW47_RS04590	COG1116	anion transmembrane transporter activity
BW47_RS04625	COG0628	permease
BW47_RS04655	COG1196	nuclear chromosome segregation
BW47_RS04660	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
BW47_RS04665	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
BW47_RS04730	COG0823	Involved in the tonB-independent uptake of proteins
BW47_RS04730	COG1506	peptidase
BW47_RS04730	COG4946	Tricorn protease homolog
BW47_RS04755	COG5012	cobalamin binding
BW47_RS04760	COG0084	hydrolase, TatD family'
BW47_RS04765	COG0632	four-way junction helicase activity
BW47_RS04785	COG5002	protein histidine kinase activity
BW47_RS04795	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
BW47_RS04820	COG0469	pyruvate kinase activity
BW47_RS04840	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
BW47_RS04845	COG0291	Belongs to the bacterial ribosomal protein bL35 family
BW47_RS04850	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
BW47_RS04855	COG0052	Belongs to the universal ribosomal protein uS2 family
BW47_RS04860	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
BW47_RS04865	COG1987	bacterial-type flagellum assembly
BW47_RS04870	COG1338	Plays a role in the flagellum-specific transport system
BW47_RS04880	COG2201	protein-glutamate methylesterase activity
BW47_RS04885	COG0835	chemotaxis
BW47_RS04890	COG2198	Histidine kinase
BW47_RS04890	COG0643	Histidine kinase
BW47_RS04900	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
BW47_RS04910	COG0101	tRNA pseudouridine synthase activity
BW47_RS04930	COG0714	Associated with various cellular activities
BW47_RS04940	COG0772	Belongs to the SEDS family
BW47_RS04945	COG0635	Involved in the biosynthesis of porphyrin-containing compound
BW47_RS04955	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
BW47_RS04960	COG0154	amidase activity
BW47_RS04975	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
BW47_RS04980	COG0049	tRNA binding
BW47_RS04985	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
BW47_RS04990	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
BW47_RS04995	COG0051	transcription antitermination factor activity, RNA binding
BW47_RS05000	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
BW47_RS05005	COG0088	Forms part of the polypeptide exit tunnel
BW47_RS05010	COG0089	rRNA binding
BW47_RS05015	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
BW47_RS05020	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
BW47_RS05025	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
BW47_RS05030	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
BW47_RS05035	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
BW47_RS05040	COG0255	Belongs to the universal ribosomal protein uL29 family
BW47_RS05045	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
BW47_RS05050	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
BW47_RS05055	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
BW47_RS05060	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
BW47_RS05065	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
BW47_RS05070	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
BW47_RS05075	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
BW47_RS05080	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
BW47_RS05085	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
BW47_RS05090	COG1841	ribosomal large subunit assembly
BW47_RS05095	COG0200	Binds to the 23S rRNA
BW47_RS05100	COG0201	protein transport
BW47_RS05105	COG0563	adenylate kinase activity
BW47_RS05115	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
BW47_RS05120	COG0257	Belongs to the bacterial ribosomal protein bL36 family
BW47_RS05125	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
BW47_RS05130	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
BW47_RS05135	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
BW47_RS05140	COG0202	RNA polymerase activity
BW47_RS05145	COG0203	ribosomal protein L17
BW47_RS05150	COG0544	peptidyl-prolyl cis-trans isomerase activity
BW47_RS05155	COG0740	serine-type endopeptidase activity
BW47_RS05160	COG0217	transcriptional regulatory protein
BW47_RS05170	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
BW47_RS05175	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
BW47_RS05180	COG0564	pseudouridine synthase activity
BW47_RS05185	COG0174	glutamine synthetase
BW47_RS05190	COG2342	PFAM TM1410 hypothetical-related protein
BW47_RS05235	COG1214	PFAM Peptidase M22, glycoprotease
BW47_RS05240	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
BW47_RS05245	COG3437	response regulator, receiver
BW47_RS05245	COG2770	Histidine kinase
BW47_RS05250	COG2078	PFAM AMMECR1 domain protein
BW47_RS05265	COG0037	tRNA processing
BW47_RS05270	COG3681	Belongs to the UPF0597 family
BW47_RS05280	COG1070	Carbohydrate kinase
BW47_RS05285	COG1509	lysine 2,3-aminomutase activity
BW47_RS05295	COG1609	Transcriptional regulator
BW47_RS05300	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
BW47_RS05305	COG0395	ABC-type sugar transport system, permease component
BW47_RS05310	COG1175	transmembrane transport
BW47_RS05320	COG1653	transport
BW47_RS05340	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
BW47_RS05355	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
BW47_RS05360	COG3481	metal-dependent phosphohydrolase, HD sub domain
BW47_RS05365	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
BW47_RS05375	COG0227	Belongs to the bacterial ribosomal protein bL28 family
BW47_RS05385	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
BW47_RS05390	COG0358	DNA primase activity
BW47_RS05400	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
BW47_RS05405	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
BW47_RS05410	COG0211	Belongs to the bacterial ribosomal protein bL27 family
BW47_RS05420	COG0261	This protein binds to 23S rRNA in the presence of protein L20
BW47_RS05430	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
BW47_RS05435	COG2176	DNA-directed DNA polymerase activity
BW47_RS05440	COG2359	stage V sporulation protein S
BW47_RS05450	COG3872	metal-dependent enzyme
BW47_RS05455	COG0019	diaminopimelate decarboxylase activity
BW47_RS05460	COG1473	amidohydrolase
BW47_RS05465	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
BW47_RS05470	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
BW47_RS05475	COG0012	GTP binding
BW47_RS05480	COG2052	Domain of unknown function (DUF370)
BW47_RS05485	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
BW47_RS05490	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
BW47_RS05505	COG0546	phosphoglycolate phosphatase activity
BW47_RS05510	COG2070	2-Nitropropane dioxygenase
BW47_RS05555	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
BW47_RS05560	COG0438	transferase activity, transferring glycosyl groups
BW47_RS05615	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
BW47_RS05645	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
BW47_RS05675	COG2865	translation initiation factor activity
BW47_RS05840	COG0840	transmembrane signaling receptor activity
BW47_RS05845	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
BW47_RS05850	COG0850	regulation of cytokinetic process
BW47_RS05860	COG1815	bacterial-type flagellum-dependent cell motility
BW47_RS05870	COG1677	Flagellar hook-basal body complex protein FliE
BW47_RS05880	COG0443	Heat shock 70 kDa protein
BW47_RS05885	COG0393	Putative heavy-metal-binding
BW47_RS05890	COG1073	alpha beta
BW47_RS05900	COG1131	(ABC) transporter
BW47_RS05905	COG1725	Transcriptional regulator
BW47_RS05910	COG0183	Belongs to the thiolase family
BW47_RS05920	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
BW47_RS05925	COG1785	Belongs to the alkaline phosphatase family
BW47_RS05930	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
BW47_RS05930	COG0493	'glutamate synthase
BW47_RS05935	COG0543	2 iron, 2 sulfur cluster binding
BW47_RS05940	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BW47_RS05970	COG2201	protein-glutamate methylesterase activity
BW47_RS05975	COG2201	protein-glutamate methylesterase activity
BW47_RS05980	COG2198	Histidine kinase
BW47_RS05980	COG0643	Histidine kinase
BW47_RS06000	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BW47_RS06015	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
BW47_RS06020	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
BW47_RS06025	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
BW47_RS06030	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
BW47_RS06040	COG1418	mRNA catabolic process
BW47_RS06045	COG3842	ATPase activity
BW47_RS06060	COG1309	transcriptional regulator
BW47_RS06065	COG0254	rRNA binding
BW47_RS06070	COG1098	S1 RNA binding domain
BW47_RS06110	COG0483	inositol monophosphate 1-phosphatase activity
BW47_RS06115	COG0768	penicillin binding
BW47_RS06120	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
BW47_RS06130	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
BW47_RS06140	COG1610	YqeY-like protein
BW47_RS06150	COG0698	ribose 5-phosphate isomerase
BW47_RS06160	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
BW47_RS06170	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
BW47_RS06175	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BW47_RS06175	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BW47_RS06180	COG0747	negative chemotaxis
BW47_RS06185	COG0601	transmembrane transport
BW47_RS06190	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BW47_RS06195	COG0444	Belongs to the ABC transporter superfamily
BW47_RS06200	COG4608	Belongs to the ABC transporter superfamily
BW47_RS06205	COG0540	Belongs to the ATCase OTCase family
BW47_RS06205	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
BW47_RS06210	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
BW47_RS06210	COG2199	diguanylate cyclase activity
BW47_RS06215	COG0735	belongs to the Fur family
BW47_RS06220	COG0450	alkyl hydroperoxide reductase
BW47_RS06225	COG1773	rubredoxin
BW47_RS06230	COG0426	domain, Protein
BW47_RS06235	COG1528	Iron-storage protein
BW47_RS06245	COG2033	superoxide reductase activity
BW47_RS06260	COG3437	response regulator, receiver
BW47_RS06270	COG1435	thymidine kinase activity
BW47_RS06275	COG0737	Belongs to the 5'-nucleotidase family
BW47_RS06285	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
BW47_RS06290	COG1863	multisubunit Na H antiporter MnhE subunit
BW47_RS06295	COG2212	antiporter activity
BW47_RS06310	COG2111	Na H antiporter
BW47_RS06310	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
BW47_RS06315	COG1006	Multisubunit Na H antiporter MnhC subunit
BW47_RS06320	COG0651	ATP synthesis coupled electron transport
BW47_RS06325	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
BW47_RS06325	COG2111	Na H antiporter
BW47_RS06335	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BW47_RS06340	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BW47_RS06345	COG0649	NAD binding
BW47_RS06360	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
BW47_RS06365	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
BW47_RS06375	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BW47_RS06385	COG0446	pyridine nucleotide-disulphide oxidoreductase
BW47_RS06390	COG1045	serine acetyltransferase
BW47_RS06395	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
BW47_RS06400	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
BW47_RS06405	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
BW47_RS06410	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
BW47_RS06415	COG0047	phosphoribosylformylglycinamidine synthase activity
BW47_RS06420	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
BW47_RS06435	COG2313	pseudouridylate synthase activity
BW47_RS06440	COG0622	Phosphoesterase
BW47_RS06445	COG1739	Uncharacterized protein family UPF0029
BW47_RS06450	COG0436	Aminotransferase
BW47_RS06455	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
BW47_RS06460	COG0640	Transcriptional regulator
BW47_RS06525	COG0720	synthase
BW47_RS06530	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
BW47_RS06555	COG0149	triose-phosphate isomerase activity
BW47_RS06555	COG0126	phosphoglycerate kinase activity
BW47_RS06560	COG0126	phosphoglycerate kinase activity
BW47_RS06565	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
BW47_RS06580	COG1157	protein secretion by the type III secretion system
BW47_RS06590	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
BW47_RS06595	COG0191	fructose-bisphosphate aldolase activity
BW47_RS06615	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
BW47_RS06620	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
BW47_RS06630	COG0233	cytoplasmic translational termination
BW47_RS06635	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
BW47_RS06640	COG0575	Belongs to the CDS family
BW47_RS06645	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
BW47_RS06650	COG1077	Cell shape determining protein MreB Mrl
BW47_RS06665	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
BW47_RS06685	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
BW47_RS06705	COG1749	Flagellar hook protein flgE
BW47_RS06710	COG1582	Flagellar protein (FlbD)
BW47_RS06720	COG1360	Flagellar Motor Protein
BW47_RS06730	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
BW47_RS06735	COG1776	CheC inhibitor of MCP methylation
BW47_RS06735	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
BW47_RS06740	COG0733	neurotransmitter:sodium symporter activity
BW47_RS06750	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
BW47_RS06755	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
BW47_RS06760	COG2239	Acts as a magnesium transporter
BW47_RS06770	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
BW47_RS06775	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
BW47_RS06790	COG1120	ATPase activity
BW47_RS06810	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
BW47_RS06815	COG1490	D-aminoacyl-tRNA deacylase activity
BW47_RS06820	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
BW47_RS06835	COG1529	Aldehyde oxidase and xanthine dehydrogenase
BW47_RS06835	COG2080	2 iron, 2 sulfur cluster binding
BW47_RS06860	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
BW47_RS06875	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
BW47_RS06905	COG0019	diaminopimelate decarboxylase activity
BW47_RS06920	COG0357	Ribosomal RNA small subunit methyltransferase G
BW47_RS06925	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
BW47_RS06965	COG2199	diguanylate cyclase activity
BW47_RS06965	COG2203	Gaf domain
BW47_RS06970	COG0584	glycerophosphoryl diester phosphodiesterase
BW47_RS06975	COG0156	8-amino-7-oxononanoate synthase activity
BW47_RS06980	COG1063	alcohol dehydrogenase
BW47_RS07000	COG0534	Mate efflux family protein
BW47_RS07010	COG1131	(ABC) transporter
BW47_RS07035	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
BW47_RS07045	COG1027	Aspartate ammonia-lyase
BW47_RS07050	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
BW47_RS07060	COG0142	geranyltranstransferase activity
BW47_RS07075	COG1078	dGTPase activity
BW47_RS07080	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
BW47_RS07105	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
BW47_RS07110	COG1660	Displays ATPase and GTPase activities
BW47_RS07115	COG0391	Required for morphogenesis under gluconeogenic growth conditions
BW47_RS07125	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
BW47_RS07130	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
BW47_RS07135	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
BW47_RS07145	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
BW47_RS07155	COG1132	(ABC) transporter
BW47_RS07170	COG0444	Belongs to the ABC transporter superfamily
BW47_RS07175	COG4608	Belongs to the ABC transporter superfamily
BW47_RS07185	COG0601	transmembrane transport
BW47_RS07190	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BW47_RS07220	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
BW47_RS07225	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
BW47_RS07230	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
BW47_RS07240	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
BW47_RS07245	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
BW47_RS07260	COG1752	Esterase of the alpha-beta hydrolase superfamily
BW47_RS07265	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
BW47_RS07275	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
BW47_RS07275	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
BW47_RS07295	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
BW47_RS07300	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
BW47_RS07310	COG0735	belongs to the Fur family
BW47_RS07315	COG0195	Participates in both transcription termination and antitermination
BW47_RS07320	COG0779	Required for maturation of 30S ribosomal subunits
BW47_RS07340	COG0343	queuine tRNA-ribosyltransferase activity
BW47_RS07350	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
BW47_RS07360	COG2151	metal-sulfur cluster biosynthetic enzyme
BW47_RS07365	COG2890	protein-(glutamine-N5) methyltransferase activity
BW47_RS07370	COG0359	binds to the 23S rRNA
BW47_RS07375	COG1234	tRNA 3'-trailer cleavage
BW47_RS07385	COG0617	tRNA 3'-terminal CCA addition
BW47_RS07385	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
BW47_RS07385	COG3620	sequence-specific DNA binding
BW47_RS07420	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
BW47_RS07425	COG1776	CheC inhibitor of MCP methylation
BW47_RS07440	COG0455	bacterial-type flagellum organization
BW47_RS07445	COG1419	protein localization to endoplasmic reticulum
BW47_RS07450	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
BW47_RS07650	COG3723	Recombinational DNA repair protein, rece pathway
BW47_RS07655	COG5377	YqaJ viral recombinase family
BW47_RS07690	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
BW47_RS07730	COG0730	response to heat
BW47_RS07740	COG1363	Peptidase, m42
BW47_RS07745	COG1774	PSP1 C-terminal conserved region
BW47_RS07755	COG0802	atpase or kinase
BW47_RS07760	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
BW47_RS07765	COG0218	Necessary for normal cell division and for the maintenance of normal septation
BW47_RS07775	COG5002	protein histidine kinase activity
BW47_RS07780	COG1639	'signal transduction protein
BW47_RS07785	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
BW47_RS07795	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
BW47_RS07810	COG0820	rRNA (adenine-C2-)-methyltransferase activity
BW47_RS07820	COG1162	GTPase activity
BW47_RS07825	COG1032	radical SAM domain protein
BW47_RS07835	COG0295	cytidine deaminase activity
BW47_RS07850	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
BW47_RS07860	COG0557	exoribonuclease II activity
BW47_RS07865	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
BW47_RS07865	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
BW47_RS07870	COG2738	Putative neutral zinc metallopeptidase
BW47_RS07875	COG0745	RESPONSE REGULATOR receiver
BW47_RS07880	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BW47_RS07885	COG3956	TIGRFAM MazG family protein
BW47_RS07890	COG0628	permease
BW47_RS07915	COG0587	DNA-directed DNA polymerase activity
BW47_RS07920	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
BW47_RS07925	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
BW47_RS07930	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
BW47_RS07935	COG2203	Gaf domain
BW47_RS07935	COG2199	diguanylate cyclase activity
BW47_RS07940	COG0812	UDP-N-acetylmuramate dehydrogenase activity
BW47_RS07945	COG1362	aminopeptidase activity
BW47_RS07970	COG1482	cell wall glycoprotein biosynthetic process
BW47_RS07980	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
BW47_RS07985	COG2255	four-way junction helicase activity
BW47_RS07990	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
BW47_RS08000	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
BW47_RS08005	COG0704	Plays a role in the regulation of phosphate uptake
BW47_RS08015	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
BW47_RS08020	COG0138	bifunctional purine biosynthesis protein purh
BW47_RS08040	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
BW47_RS08045	COG2894	cell division
BW47_RS08070	COG0552	protein localization to endoplasmic reticulum
BW47_RS08080	COG3584	3D domain protein
BW47_RS08090	COG0482	sulfurtransferase activity
BW47_RS08095	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
BW47_RS08095	COG0037	tRNA processing
BW47_RS08100	COG1316	TRANSCRIPTIONal
BW47_RS08105	COG1515	deoxyribonuclease V activity
BW47_RS08120	COG1242	4 iron, 4 sulfur cluster binding
BW47_RS08125	COG0402	S-adenosylhomocysteine deaminase activity
BW47_RS08130	COG0799	negative regulation of ribosome biogenesis
BW47_RS08135	COG0285	dihydrofolate synthase activity
BW47_RS08140	COG0525	valine-tRNA ligase activity
BW47_RS08150	COG4656	Part of a membrane complex involved in electron transport
BW47_RS08155	COG4658	electron transport chain
BW47_RS08165	COG4660	Part of a membrane complex involved in electron transport
BW47_RS08170	COG4657	Part of a membrane complex involved in electron transport
BW47_RS08190	COG0516	GMP reductase activity
BW47_RS08190	COG0517	IMP dehydrogenase activity
BW47_RS08195	COG0840	transmembrane signaling receptor activity
BW47_RS08200	COG0366	Alpha amylase catalytic
BW47_RS08205	COG2226	methyltransferase
BW47_RS08205	COG1073	alpha beta
BW47_RS08210	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
BW47_RS08215	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
BW47_RS08220	COG0157	Belongs to the NadC ModD family
BW47_RS08225	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
BW47_RS08230	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
BW47_RS08240	COG1268	BioY protein
BW47_RS08245	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
BW47_RS08250	COG1635	Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur
BW47_RS08260	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
BW47_RS08270	COG1992	Thiamine-phosphate synthase
BW47_RS08270	COG0351	phosphomethylpyrimidine kinase
BW47_RS08275	COG0205	6-phosphofructokinase activity
BW47_RS08285	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
BW47_RS08320	COG0571	ribonuclease III activity
BW47_RS08325	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
BW47_RS08325	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
BW47_RS08330	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
BW47_RS08330	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
BW47_RS08335	COG0728	peptidoglycan biosynthetic process
BW47_RS08340	COG2878	Part of a membrane complex involved in electron transport
BW47_RS08345	COG0758	DNA mediated transformation
BW47_RS08350	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
BW47_RS08360	COG1185	polyribonucleotide nucleotidyltransferase activity
BW47_RS08375	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
BW47_RS08380	COG1175	transmembrane transport
BW47_RS08385	COG0395	ABC-type sugar transport system, permease component
BW47_RS08390	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
BW47_RS08395	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
BW47_RS08400	COG1366	Belongs to the anti-sigma-factor antagonist family
BW47_RS08405	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
BW47_RS08410	COG0539	negative regulation of cytoplasmic translation
BW47_RS08410	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
BW47_RS08415	COG1160	GTP binding
BW47_RS08420	COG1744	ABC transporter substrate-binding protein PnrA-like
BW47_RS08435	COG0230	Belongs to the bacterial ribosomal protein bL34 family
BW47_RS08440	COG0594	ribonuclease P activity
BW47_RS08445	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
BW47_RS08450	COG0706	membrane insertase activity
BW47_RS08455	COG1847	R3H domain protein
BW47_RS08465	COG2985	domain, Protein
BW47_RS08465	COG0569	domain protein
BW47_RS08470	COG0174	glutamine synthetase
BW47_RS08475	COG2199	diguanylate cyclase activity
BW47_RS08475	COG2203	Gaf domain
BW47_RS08485	COG2723	6-phospho-beta-galactosidase activity
BW47_RS08535	COG1132	(ABC) transporter
BW47_RS08550	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
BW47_RS08555	COG1518	maintenance of DNA repeat elements
BW47_RS08560	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
BW47_RS08600	COG3337	CRISPR-associated protein (Cas_Cmr5)
BW47_RS08635	COG1353	crispr-associated protein
BW47_RS08645	COG1337	RAMP superfamily
BW47_RS08695	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
BW47_RS08715	COG0556	nucleotide-excision repair
BW47_RS08725	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
BW47_RS08740	COG2189	Belongs to the N(4) N(6)-methyltransferase family
BW47_RS08755	COG2361	Protein of unknown function DUF86
BW47_RS08770	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
BW47_RS08780	COG0438	transferase activity, transferring glycosyl groups
BW47_RS08785	COG3842	ATPase activity
BW47_RS08850	COG3842	ATPase activity
BW47_RS08855	COG0438	transferase activity, transferring glycosyl groups
BW47_RS08870	COG0730	response to heat
BW47_RS08875	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BW47_RS08890	COG0768	penicillin binding
BW47_RS08900	COG0275	rRNA processing
BW47_RS08910	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
BW47_RS08920	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
BW47_RS08925	COG4608	Belongs to the ABC transporter superfamily
BW47_RS08935	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BW47_RS08940	COG0601	transmembrane transport
BW47_RS08945	COG0322	excinuclease ABC activity
BW47_RS08955	COG0509	glycine decarboxylation via glycine cleavage system
BW47_RS08960	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
BW47_RS08960	COG1918	ferrous iron import across plasma membrane
BW47_RS08975	COG1596	polysaccharide export
BW47_RS08975	COG1555	photosystem II stabilization
BW47_RS08985	COG4796	Type ii and iii secretion system protein
BW47_RS09015	COG1459	type II secretion system
BW47_RS09020	COG1122	ATPase activity
BW47_RS09025	COG2813	Specifically methylates the guanine in position
BW47_RS09035	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
BW47_RS09045	COG0268	Binds directly to 16S ribosomal RNA
BW47_RS09050	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
BW47_RS09065	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
BW47_RS09070	COG1923	regulation of RNA biosynthetic process
BW47_RS09085	COG0572	uridine kinase
BW47_RS09090	COG1530	ribonuclease E activity
BW47_RS09095	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
BW47_RS09105	COG1013	pyruvate-flavodoxin oxidoreductase activity
BW47_RS09120	COG2201	protein-glutamate methylesterase activity
BW47_RS09160	COG0840	transmembrane signaling receptor activity
BW47_RS09165	COG2986	histidine ammonia-lyase
BW47_RS09205	COG1363	Peptidase, m42
BW47_RS09230	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
BW47_RS09235	COG0220	tRNA (guanine-N7-)-methyltransferase activity
BW47_RS09245	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
BW47_RS09245	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
BW47_RS09255	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
BW47_RS09265	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BW47_RS09270	COG0058	SHG alpha-glucan phosphorylase activity
BW47_RS09275	COG0681	Belongs to the peptidase S26 family
BW47_RS09280	COG0335	large ribosomal subunit rRNA binding
BW47_RS09285	COG4752	Belongs to the RNA methyltransferase TrmD family
BW47_RS09290	COG0336	Belongs to the RNA methyltransferase TrmD family
BW47_RS09295	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
BW47_RS09300	COG1837	Belongs to the UPF0109 family
BW47_RS09305	COG0228	four-way junction DNA binding
BW47_RS09310	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
BW47_RS09320	COG1176	ABC-type spermidine putrescine transport system, permease component I
BW47_RS09335	COG1059	Responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine 7-oxoG) from DNA. Also nicks DNA at apurinic apyrimidinic sites (AP sites)
BW47_RS09350	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
BW47_RS09360	COG0840	transmembrane signaling receptor activity
BW47_RS09365	COG2199	diguanylate cyclase activity
BW47_RS09365	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
BW47_RS09380	COG1653	transport
BW47_RS09385	COG0438	transferase activity, transferring glycosyl groups
BW47_RS09395	COG5002	protein histidine kinase activity
BW47_RS09400	COG0745	RESPONSE REGULATOR receiver
BW47_RS09405	COG0704	Plays a role in the regulation of phosphate uptake
BW47_RS09410	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
BW47_RS09415	COG0573	inorganic phosphate transmembrane transporter activity
BW47_RS09430	COG1012	belongs to the aldehyde dehydrogenase family
BW47_RS09435	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BW47_RS09440	COG1846	Transcriptional regulator
BW47_RS09450	COG1105	Belongs to the carbohydrate kinase PfkB family
BW47_RS09455	COG1028	Short-chain dehydrogenase reductase Sdr
BW47_RS09460	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
BW47_RS09465	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
BW47_RS09470	COG0745	RESPONSE REGULATOR receiver
BW47_RS09490	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
BW47_RS09495	COG0166	Belongs to the GPI family
BW47_RS09505	COG0237	dephospho-CoA kinase activity
BW47_RS09510	COG2199	diguanylate cyclase activity
BW47_RS09515	COG0556	nucleotide-excision repair
BW47_RS09520	COG1293	RNA-binding protein homologous to eukaryotic snRNP
BW47_RS09555	COG1323	Belongs to the UPF0348 family
BW47_RS09560	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
BW47_RS09570	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
BW47_RS09575	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
BW47_RS09585	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
BW47_RS09585	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
BW47_RS09590	COG0235	Class ii aldolase
BW47_RS09600	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
BW47_RS09600	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
BW47_RS09610	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
BW47_RS09620	COG3290	protein histidine kinase activity
BW47_RS09620	COG0840	transmembrane signaling receptor activity
BW47_RS09635	COG0045	succinate-CoA ligase (ADP-forming) activity
BW47_RS09645	COG0569	domain protein
BW47_RS09645	COG2985	domain, Protein
BW47_RS09650	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
BW47_RS09660	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BW47_RS09665	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
BW47_RS09670	COG2171	N-acyltransferase activity
BW47_RS09680	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
BW47_RS09690	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
BW47_RS09695	COG0815	Transfers the fatty acyl group on membrane lipoproteins
BW47_RS09710	COG0404	The glycine cleavage system catalyzes the degradation of glycine
BW47_RS09715	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
BW47_RS09720	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
BW47_RS09725	COG1454	alcohol dehydrogenase
BW47_RS09745	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BW47_RS09750	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
BW47_RS09765	COG0674	pyruvate-flavodoxin oxidoreductase activity
BW47_RS09765	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
BW47_RS09770	COG1144	Oxidoreductase
BW47_RS09775	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
BW47_RS09780	COG0470	DNA polymerase III
BW47_RS09785	COG1122	ATPase activity
BW47_RS09790	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
BW47_RS09805	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BW47_RS09810	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BW47_RS09815	COG1862	Preprotein translocase
BW47_RS09820	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
BW47_RS09830	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
BW47_RS09835	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
BW47_RS09850	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
BW47_RS09865	COG1570	exodeoxyribonuclease VII activity
BW47_RS09870	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BW47_RS09870	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BW47_RS09885	COG1193	negative regulation of DNA recombination
BW47_RS09895	COG0306	phosphate transporter
BW47_RS09910	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
BW47_RS09925	COG0280	phosphate acetyltransferase