locus-tag	class	description
TMEL_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
TMEL_RS00010	COG1141	Ferredoxin
TMEL_RS00015	COG1132	(ABC) transporter
TMEL_RS00025	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
TMEL_RS00040	COG1132	(ABC) transporter
TMEL_RS00070	COG0446	pyridine nucleotide-disulphide oxidoreductase
TMEL_RS00070	COG1902	pentaerythritol trinitrate reductase activity
TMEL_RS00100	COG1012	belongs to the aldehyde dehydrogenase family
TMEL_RS00110	COG1744	ABC transporter substrate-binding protein PnrA-like
TMEL_RS00115	COG3845	ABC transporter
TMEL_RS00120	COG4603	Belongs to the binding-protein-dependent transport system permease family
TMEL_RS00125	COG1079	Belongs to the binding-protein-dependent transport system permease family
TMEL_RS00140	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
TMEL_RS00145	COG1307	EDD domain protein, DegV family
TMEL_RS00150	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
TMEL_RS00155	COG0542	response to heat
TMEL_RS00190	COG0492	ferredoxin-NADP+ reductase activity
TMEL_RS00195	COG1335	isochorismatase
TMEL_RS00200	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
TMEL_RS00205	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
TMEL_RS00215	COG1564	THIamine pyrophosphokinase
TMEL_RS00220	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
TMEL_RS00225	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
TMEL_RS00230	COG4139	cobalamin transport
TMEL_RS00240	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
TMEL_RS00250	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
TMEL_RS00255	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
TMEL_RS00255	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
TMEL_RS00260	COG0307	riboflavin synthase, alpha
TMEL_RS00265	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
TMEL_RS00265	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
TMEL_RS00270	COG0840	transmembrane signaling receptor activity
TMEL_RS00275	COG0822	iron-sulfur transferase activity
TMEL_RS00280	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
TMEL_RS00290	COG0719	Fe-S assembly protein
TMEL_RS00300	COG0459	protein refolding
TMEL_RS00305	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
TMEL_RS00325	COG0312	modulator of DNA gyrase
TMEL_RS00330	COG0312	modulator of DNA gyrase
TMEL_RS00345	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
TMEL_RS00350	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
TMEL_RS00355	COG0442	prolyl-tRNA aminoacylation
TMEL_RS00360	COG0215	cysteine-tRNA ligase activity
TMEL_RS00365	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
TMEL_RS00385	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TMEL_RS00390	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
TMEL_RS00395	COG1335	isochorismatase
TMEL_RS00400	COG1230	cation diffusion facilitator family transporter
TMEL_RS00415	COG0297	glycogen (starch) synthase activity
TMEL_RS00425	COG3290	protein histidine kinase activity
TMEL_RS00425	COG3829	transcription factor binding
TMEL_RS00435	COG1181	Belongs to the D-alanine--D-alanine ligase family
TMEL_RS00450	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
TMEL_RS00455	COG2379	hydroxypyruvate reductase
TMEL_RS00460	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
TMEL_RS00465	COG0484	heat shock protein binding
TMEL_RS00470	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
TMEL_RS00480	COG0477	Major facilitator Superfamily
TMEL_RS00485	COG1827	regulation of RNA biosynthetic process
TMEL_RS00490	COG1272	protein, Hemolysin III
TMEL_RS00495	COG1047	Peptidyl-prolyl cis-trans
TMEL_RS00505	COG0535	radical SAM domain protein
TMEL_RS00510	COG1363	Peptidase, m42
TMEL_RS00520	COG1758	RNA polymerase activity
TMEL_RS00525	COG0194	GDP metabolic process
TMEL_RS00530	COG2052	Domain of unknown function (DUF370)
TMEL_RS00565	COG3426	butyrate kinase activity
TMEL_RS00570	COG0280	phosphate acetyltransferase
TMEL_RS00575	COG3426	butyrate kinase activity
TMEL_RS00580	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
TMEL_RS00585	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
TMEL_RS00590	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
TMEL_RS00595	COG1966	Carbon starvation protein
TMEL_RS00600	COG3279	Response regulator of the LytR AlgR family
TMEL_RS00605	COG3275	phosphorelay sensor kinase activity
TMEL_RS00620	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
TMEL_RS00625	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
TMEL_RS00630	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
TMEL_RS00635	COG0402	S-adenosylhomocysteine deaminase activity
TMEL_RS00640	COG0167	dihydroorotate dehydrogenase activity
TMEL_RS00670	COG2359	stage V sporulation protein S
TMEL_RS00675	COG0737	Belongs to the 5'-nucleotidase family
TMEL_RS00680	COG1132	(ABC) transporter
TMEL_RS00710	COG0301	tRNA thio-modification
TMEL_RS00725	COG1132	(ABC) transporter
TMEL_RS00735	COG1846	Transcriptional regulator
TMEL_RS00740	COG2373	Large extracellular alpha-helical protein
TMEL_RS00750	COG3234	Protein of unknown function (DUF1175)
TMEL_RS00765	COG0446	pyridine nucleotide-disulphide oxidoreductase
TMEL_RS00780	COG0840	transmembrane signaling receptor activity
TMEL_RS00795	COG0534	Mate efflux family protein
TMEL_RS00800	COG0667	Aldo Keto reductase
TMEL_RS00815	COG1131	(ABC) transporter
TMEL_RS00825	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
TMEL_RS00825	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
TMEL_RS00830	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
TMEL_RS00830	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
TMEL_RS00835	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
TMEL_RS00845	COG1573	uracil-dna glycosylase
TMEL_RS00850	COG0574	Belongs to the PEP-utilizing enzyme family
TMEL_RS00850	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
TMEL_RS00860	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
TMEL_RS00865	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
TMEL_RS00870	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
TMEL_RS00875	COG0193	aminoacyl-tRNA hydrolase activity
TMEL_RS00895	COG0529	Catalyzes the synthesis of activated sulfate
TMEL_RS00900	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
TMEL_RS00905	COG4974	Belongs to the 'phage' integrase family
TMEL_RS00930	COG0148	phosphopyruvate hydratase activity
TMEL_RS00940	COG3206	protein involved in exopolysaccharide biosynthesis
TMEL_RS00945	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
TMEL_RS00955	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TMEL_RS00960	COG0116	Belongs to the methyltransferase superfamily
TMEL_RS00965	COG1993	acr, cog1993
TMEL_RS00970	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
TMEL_RS00980	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
TMEL_RS00985	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
TMEL_RS00995	COG2264	protein methyltransferase activity
TMEL_RS01000	COG0739	heme binding
TMEL_RS01005	COG1607	acyl-coa hydrolase
TMEL_RS01010	COG3246	L-lysine catabolic process to acetate
TMEL_RS01015	COG0604	alcohol dehydrogenase
TMEL_RS01020	COG1509	lysine 2,3-aminomutase activity
TMEL_RS01025	COG2030	dehydratase
TMEL_RS01040	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
TMEL_RS01045	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
TMEL_RS01060	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
TMEL_RS01080	COG1472	Belongs to the glycosyl hydrolase 3 family
TMEL_RS01105	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
TMEL_RS01110	COG0037	tRNA processing
TMEL_RS01125	COG1968	undecaprenyl-diphosphatase activity
TMEL_RS01130	COG1228	amidohydrolase
TMEL_RS01145	COG0424	maF-like protein
TMEL_RS01150	COG2003	Belongs to the UPF0758 family
TMEL_RS01165	COG1215	transferase activity, transferring glycosyl groups
TMEL_RS01170	COG1442	glycosyl transferase family 8
TMEL_RS01170	COG1216	Glycosyl transferase, family 2
TMEL_RS01195	COG0793	Belongs to the peptidase S41A family
TMEL_RS01200	COG2226	methyltransferase
TMEL_RS01215	COG1713	HD superfamily hydrolase involved in NAD metabolism
TMEL_RS01225	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
TMEL_RS01230	COG0009	L-threonylcarbamoyladenylate synthase
TMEL_RS01240	COG0481	GTPase activity
TMEL_RS01245	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
TMEL_RS01250	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
TMEL_RS01255	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
TMEL_RS01260	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
TMEL_RS01270	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
TMEL_RS01280	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
TMEL_RS01285	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
TMEL_RS01295	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
TMEL_RS01300	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
TMEL_RS01305	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
TMEL_RS01310	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
TMEL_RS01325	COG1461	Dihydroxyacetone kinase
TMEL_RS01335	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
TMEL_RS01340	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
TMEL_RS01345	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
TMEL_RS01355	COG0495	leucyl-tRNA aminoacylation
TMEL_RS01375	COG0750	zinc metalloprotease
TMEL_RS01390	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
TMEL_RS01400	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
TMEL_RS01405	COG0543	2 iron, 2 sulfur cluster binding
TMEL_RS01410	COG0167	dihydroorotate dehydrogenase activity
TMEL_RS01415	COG0284	orotidine-5'-phosphate decarboxylase activity
TMEL_RS01420	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
TMEL_RS01445	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
TMEL_RS01460	COG2183	response to ionizing radiation
TMEL_RS01465	COG0835	chemotaxis
TMEL_RS01470	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
TMEL_RS01480	COG1278	Cold shock
TMEL_RS01485	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
TMEL_RS01490	COG0095	Lipoate-protein ligase
TMEL_RS01510	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
TMEL_RS01515	COG5002	protein histidine kinase activity
TMEL_RS01520	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
TMEL_RS01530	COG1307	EDD domain protein, DegV family
TMEL_RS01535	COG0355	proton-transporting ATP synthase activity, rotational mechanism
TMEL_RS01540	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
TMEL_RS01545	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
TMEL_RS01550	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
TMEL_RS01555	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
TMEL_RS01560	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
TMEL_RS01565	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
TMEL_RS01585	COG0006	proline dipeptidase activity
TMEL_RS01595	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
TMEL_RS01600	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
TMEL_RS01600	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
TMEL_RS01610	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
TMEL_RS01615	COG5002	protein histidine kinase activity
TMEL_RS01620	COG2759	Belongs to the formate--tetrahydrofolate ligase family
TMEL_RS01625	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
TMEL_RS01645	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
TMEL_RS01655	COG0537	adenosine 5'-monophosphoramidase activity
TMEL_RS01660	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
TMEL_RS01670	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
TMEL_RS01680	COG4112	unkown
TMEL_RS01685	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
TMEL_RS01690	COG1067	ATP-dependent peptidase activity
TMEL_RS01695	COG0180	Tryptophanyl-tRNA synthetase
TMEL_RS01700	COG0668	transmembrane transport
TMEL_RS01705	COG0840	transmembrane signaling receptor activity
TMEL_RS01730	COG4786	Flagellar basal body rod
TMEL_RS01730	COG1256	bacterial-type flagellum assembly
TMEL_RS01730	COG4786	Flagellar basal body rod
TMEL_RS01730	COG1256	bacterial-type flagellum assembly
TMEL_RS01780	COG1760	l-serine dehydratase
TMEL_RS01790	COG1543	Belongs to the glycosyl hydrolase 57 family
TMEL_RS01795	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
TMEL_RS01800	COG1144	Oxidoreductase
TMEL_RS01805	COG0674	pyruvate-flavodoxin oxidoreductase activity
TMEL_RS01810	COG1013	pyruvate-flavodoxin oxidoreductase activity
TMEL_RS01815	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
TMEL_RS01850	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
TMEL_RS01855	COG1518	maintenance of DNA repeat elements
TMEL_RS01910	COG0501	Belongs to the peptidase M48B family
TMEL_RS01915	COG0110	maltose O-acetyltransferase activity
TMEL_RS01935	COG0438	transferase activity, transferring glycosyl groups
TMEL_RS01950	COG0514	ATP-dependent DNA helicase (RecQ)
TMEL_RS01980	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
TMEL_RS01985	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
TMEL_RS02000	COG0436	Aminotransferase
TMEL_RS02005	COG2045	Belongs to the ComB family
TMEL_RS02015	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
TMEL_RS02025	COG0105	UTP biosynthetic process
TMEL_RS02035	COG3864	Putative metallopeptidase domain
TMEL_RS02050	COG0151	Belongs to the GarS family
TMEL_RS02055	COG0138	bifunctional purine biosynthesis protein purh
TMEL_RS02060	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
TMEL_RS02065	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
TMEL_RS02095	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
TMEL_RS02130	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
TMEL_RS02155	COG4555	ABC transporter
TMEL_RS02160	COG0842	Transport permease protein
TMEL_RS02165	COG3409	Peptidoglycan-binding domain 1 protein
TMEL_RS02165	COG0793	Belongs to the peptidase S41A family
TMEL_RS02190	COG0542	response to heat
TMEL_RS02195	COG1773	rubredoxin
TMEL_RS02210	COG1187	pseudouridine synthase activity
TMEL_RS02215	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
TMEL_RS02220	COG1074	ATP-dependent DNA helicase activity
TMEL_RS02240	COG3345	alpha-galactosidase
TMEL_RS02245	COG1085	galactose-1-phosphate uridylyltransferase
TMEL_RS02250	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
TMEL_RS02265	COG0776	regulation of translation
TMEL_RS02270	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
TMEL_RS02275	COG0432	Pfam Uncharacterised protein family UPF0047
TMEL_RS02285	COG0803	Belongs to the bacterial solute-binding protein 9 family
TMEL_RS02290	COG1121	(ABC) transporter
TMEL_RS02295	COG1108	ABC-type Mn2 Zn2 transport systems permease components
TMEL_RS02305	COG0196	riboflavin kinase activity
TMEL_RS02310	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
TMEL_RS02325	COG2252	PERMEase
TMEL_RS02380	COG1131	(ABC) transporter
TMEL_RS02405	COG1523	belongs to the glycosyl hydrolase 13 family
TMEL_RS02410	COG0745	RESPONSE REGULATOR receiver
TMEL_RS02415	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
TMEL_RS02425	COG0697	spore germination
TMEL_RS02430	COG1077	Cell shape determining protein MreB Mrl
TMEL_RS02455	COG0765	amino acid transport
TMEL_RS02460	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
TMEL_RS02465	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
TMEL_RS02470	COG0416	fatty acid biosynthetic process
TMEL_RS02475	COG0333	Belongs to the bacterial ribosomal protein bL32 family
TMEL_RS02495	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
TMEL_RS02500	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
TMEL_RS02505	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
TMEL_RS02520	COG0528	UMP kinase activity
TMEL_RS02525	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
TMEL_RS02530	COG1406	Chemotaxis phosphatase CheX
TMEL_RS02535	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
TMEL_RS02540	COG1181	Belongs to the D-alanine--D-alanine ligase family
TMEL_RS02545	COG2267	carboxylic ester hydrolase activity
TMEL_RS02550	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
TMEL_RS02570	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
TMEL_RS02585	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
TMEL_RS02595	COG3437	response regulator, receiver
TMEL_RS02595	COG0784	Response regulator, receiver
TMEL_RS02600	COG3852	Histidine kinase
TMEL_RS02615	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
TMEL_RS02620	COG0085	RNA polymerase activity
TMEL_RS02625	COG0222	ribosome binding
TMEL_RS02630	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
TMEL_RS02645	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
TMEL_RS02650	COG0367	asparagine synthase
TMEL_RS02655	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
TMEL_RS02665	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
TMEL_RS02685	COG0463	Glycosyl transferase, family 2
TMEL_RS02685	COG0457	Tetratricopeptide repeat
TMEL_RS02690	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
TMEL_RS02695	COG0305	Participates in initiation and elongation during chromosome replication
TMEL_RS02715	COG0251	oxidation-reduction process
TMEL_RS02725	COG2211	Major facilitator Superfamily
TMEL_RS02730	COG1803	Methylglyoxal synthase
TMEL_RS02735	COG0561	phosphatase activity
TMEL_RS02745	COG0017	Asparaginyl-tRNA synthetase
TMEL_RS02750	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
TMEL_RS02765	COG1469	GTP cyclohydrolase I activity
TMEL_RS02775	COG0438	transferase activity, transferring glycosyl groups
TMEL_RS02780	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
TMEL_RS02785	COG0592	DNA-directed DNA polymerase activity
TMEL_RS02820	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
TMEL_RS02840	COG1376	ErfK ybiS ycfS ynhG family protein
TMEL_RS02860	COG0785	Cytochrome C biogenesis protein
TMEL_RS02900	COG1516	flagellar protein fliS
TMEL_RS02915	COG4608	Belongs to the ABC transporter superfamily
TMEL_RS02920	COG0444	Belongs to the ABC transporter superfamily
TMEL_RS02930	COG0601	transmembrane transport
TMEL_RS02935	COG4166	transmembrane transport
TMEL_RS02940	COG0742	ribosomal rna small subunit methyltransferase
TMEL_RS02945	COG1177	transmembrane transport
TMEL_RS02955	COG3842	ATPase activity
TMEL_RS02960	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
TMEL_RS02965	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
TMEL_RS02970	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
TMEL_RS02980	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
TMEL_RS02990	COG1811	Na channel or pump
TMEL_RS03000	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
TMEL_RS03005	COG1480	7TM receptor with intracellular HD hydrolase
TMEL_RS03025	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
TMEL_RS03030	COG0511	ligase activity, forming carbon-carbon bonds
TMEL_RS03045	COG0346	lactoylglutathione lyase activity
TMEL_RS03060	COG0653	protein targeting
TMEL_RS03085	COG3833	ABC-type maltose transport systems, permease component
TMEL_RS03090	COG1175	transmembrane transport
TMEL_RS03100	COG0542	response to heat
TMEL_RS03105	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
TMEL_RS03120	COG0719	Fe-S assembly protein
TMEL_RS03130	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
TMEL_RS03185	COG1328	CTP reductase activity
TMEL_RS03235	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
TMEL_RS03250	COG0446	pyridine nucleotide-disulphide oxidoreductase
TMEL_RS03265	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
TMEL_RS03290	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
TMEL_RS03295	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
TMEL_RS03300	COG0516	GMP reductase activity
TMEL_RS03300	COG0517	IMP dehydrogenase activity
TMEL_RS03310	COG0330	HflC and HflK could
TMEL_RS03315	COG1592	Rubrerythrin
TMEL_RS03320	COG0751	glycine-tRNA ligase activity
TMEL_RS03325	COG0752	glycyl-tRNA synthetase alpha subunit
TMEL_RS03335	COG0772	Belongs to the SEDS family
TMEL_RS03350	COG0360	Binds together with S18 to 16S ribosomal RNA
TMEL_RS03355	COG0629	single-stranded DNA binding
TMEL_RS03360	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
TMEL_RS03375	COG0267	Belongs to the bacterial ribosomal protein bL33 family
TMEL_RS03385	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
TMEL_RS03390	COG0250	Participates in transcription elongation, termination and antitermination
TMEL_RS03395	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
TMEL_RS03400	COG0081	regulation of translation
TMEL_RS03430	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
TMEL_RS03445	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
TMEL_RS03455	COG4659	FMN binding
TMEL_RS03465	COG0662	Cupin 2, conserved barrel domain protein
TMEL_RS03465	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
TMEL_RS03470	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
TMEL_RS03475	COG2086	electron transfer activity
TMEL_RS03480	COG1960	acyl-CoA dehydrogenase activity
TMEL_RS03515	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
TMEL_RS03525	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
TMEL_RS03530	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
TMEL_RS03540	COG1706	bacterial-type flagellum-dependent cell motility
TMEL_RS03545	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
TMEL_RS03555	COG0187	DNA topoisomerase II activity
TMEL_RS03565	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
TMEL_RS03570	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TMEL_RS03575	COG0517	IMP dehydrogenase activity
TMEL_RS03575	COG0516	GMP reductase activity
TMEL_RS03585	COG1132	(ABC) transporter
TMEL_RS03610	COG2217	Heavy metal translocating P-type atpase
TMEL_RS03630	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
TMEL_RS03645	COG1472	Belongs to the glycosyl hydrolase 3 family
TMEL_RS03655	COG1175	transmembrane transport
TMEL_RS03660	COG0395	ABC-type sugar transport system, permease component
TMEL_RS03675	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
TMEL_RS03690	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
TMEL_RS03730	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
TMEL_RS03735	COG0181	hydroxymethylbilane synthase activity
TMEL_RS03745	COG0113	porphobilinogen synthase activity
TMEL_RS03755	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
TMEL_RS03760	COG0310	cobalt ion transport
TMEL_RS03775	COG1122	ATPase activity
TMEL_RS03790	COG0519	Catalyzes the synthesis of GMP from XMP
TMEL_RS03790	COG0518	GMP synthase (glutamine-hydrolyzing) activity
TMEL_RS03795	COG1704	LemA family
TMEL_RS03815	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
TMEL_RS03820	COG0306	phosphate transporter
TMEL_RS03835	COG1410	methionine synthase
TMEL_RS03835	COG0646	methionine synthase
TMEL_RS03845	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
TMEL_RS03860	COG0527	aspartate kinase activity
TMEL_RS03860	COG0460	homoserine dehydrogenase
TMEL_RS03870	COG0366	Alpha amylase catalytic
TMEL_RS03880	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
TMEL_RS03890	COG1131	(ABC) transporter
TMEL_RS03900	COG4565	transcriptional regulatory protein
TMEL_RS03910	COG0124	histidyl-tRNA synthetase
TMEL_RS03935	COG0840	transmembrane signaling receptor activity
TMEL_RS03940	COG5001	Diguanylate cyclase
TMEL_RS03940	COG3300	MHYT domain
TMEL_RS03945	COG0395	ABC-type sugar transport system, permease component
TMEL_RS03960	COG1151	hydroxylamine reductase activity
TMEL_RS03975	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
TMEL_RS03990	COG0384	phenazine biosynthesis protein PhzF
TMEL_RS03995	COG4948	Mandelate Racemase Muconate Lactonizing
TMEL_RS04000	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
TMEL_RS04015	COG1486	melibiose metabolic process
TMEL_RS04035	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
TMEL_RS04040	COG0366	Alpha amylase catalytic
TMEL_RS04055	COG3706	GGDEF domain
TMEL_RS04060	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TMEL_RS04075	COG1595	DNA-templated transcription, initiation
TMEL_RS04105	COG1546	Belongs to the CinA family
TMEL_RS04105	COG1058	Belongs to the CinA family
TMEL_RS04110	COG0504	CTP synthase activity
TMEL_RS04115	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
TMEL_RS04120	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
TMEL_RS04130	COG1392	Phosphate transport regulator
TMEL_RS04135	COG0306	phosphate transporter
TMEL_RS04140	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
TMEL_RS04170	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
TMEL_RS04175	COG4869	propanediol catabolic process
TMEL_RS04195	COG1006	Multisubunit Na H antiporter MnhC subunit
TMEL_RS04200	COG0651	ATP synthesis coupled electron transport
TMEL_RS04205	COG0205	6-phosphofructokinase activity
TMEL_RS04210	COG1979	alcohol dehydrogenase
TMEL_RS04215	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
TMEL_RS04220	COG0072	phenylalanine-tRNA ligase activity
TMEL_RS04220	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TMEL_RS04240	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
TMEL_RS04250	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
TMEL_RS04270	COG1175	transmembrane transport
TMEL_RS04275	COG0395	ABC-type sugar transport system, permease component
TMEL_RS04285	COG3706	GGDEF domain
TMEL_RS04290	COG4399	Belongs to the UPF0754 family
TMEL_RS04295	COG0445	tRNA wobble uridine modification
TMEL_RS04300	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
TMEL_RS04305	COG1489	DNA binding
TMEL_RS04320	COG0640	Transcriptional regulator
TMEL_RS04325	COG0534	Mate efflux family protein
TMEL_RS04330	COG0488	(ABC) transporter
TMEL_RS04350	COG0489	protein tyrosine kinase activity
TMEL_RS04360	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
TMEL_RS04365	COG0242	peptide deformylase activity
TMEL_RS04370	COG0513	Belongs to the DEAD box helicase family
TMEL_RS04380	COG1137	ATPase activity
TMEL_RS04395	COG0745	RESPONSE REGULATOR receiver
TMEL_RS04405	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
TMEL_RS04415	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
TMEL_RS04425	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
TMEL_RS04430	COG1684	flagellar biosynthetic protein fliR
TMEL_RS04440	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
TMEL_RS04445	COG2199	diguanylate cyclase activity
TMEL_RS04445	COG2203	Gaf domain
TMEL_RS04460	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
TMEL_RS04470	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
TMEL_RS04485	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
TMEL_RS04520	COG1187	pseudouridine synthase activity
TMEL_RS04525	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
TMEL_RS04535	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
TMEL_RS04540	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
TMEL_RS04565	COG1116	anion transmembrane transporter activity
TMEL_RS04600	COG0628	permease
TMEL_RS04630	COG1196	nuclear chromosome segregation
TMEL_RS04635	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
TMEL_RS04640	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
TMEL_RS04705	COG1506	peptidase
TMEL_RS04705	COG0823	Involved in the tonB-independent uptake of proteins
TMEL_RS04705	COG4946	Tricorn protease homolog
TMEL_RS04730	COG5012	cobalamin binding
TMEL_RS04735	COG0084	hydrolase, TatD family'
TMEL_RS04740	COG0632	four-way junction helicase activity
TMEL_RS04760	COG5002	protein histidine kinase activity
TMEL_RS04770	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
TMEL_RS04795	COG0469	pyruvate kinase activity
TMEL_RS04815	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
TMEL_RS04820	COG0291	Belongs to the bacterial ribosomal protein bL35 family
TMEL_RS04825	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
TMEL_RS04830	COG0052	Belongs to the universal ribosomal protein uS2 family
TMEL_RS04835	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
TMEL_RS04840	COG1987	bacterial-type flagellum assembly
TMEL_RS04845	COG1338	Plays a role in the flagellum-specific transport system
TMEL_RS04855	COG2201	protein-glutamate methylesterase activity
TMEL_RS04860	COG0835	chemotaxis
TMEL_RS04865	COG0643	Histidine kinase
TMEL_RS04865	COG2198	Histidine kinase
TMEL_RS04875	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
TMEL_RS04885	COG0101	tRNA pseudouridine synthase activity
TMEL_RS04905	COG0714	Associated with various cellular activities
TMEL_RS04915	COG0772	Belongs to the SEDS family
TMEL_RS04920	COG0635	Involved in the biosynthesis of porphyrin-containing compound
TMEL_RS04930	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
TMEL_RS04935	COG0154	amidase activity
TMEL_RS04950	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
TMEL_RS04955	COG0049	tRNA binding
TMEL_RS04960	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
TMEL_RS04965	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
TMEL_RS04970	COG0051	transcription antitermination factor activity, RNA binding
TMEL_RS04975	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
TMEL_RS04980	COG0088	Forms part of the polypeptide exit tunnel
TMEL_RS04985	COG0089	rRNA binding
TMEL_RS04990	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
TMEL_RS04995	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
TMEL_RS05000	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
TMEL_RS05005	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
TMEL_RS05010	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
TMEL_RS05015	COG0255	Belongs to the universal ribosomal protein uL29 family
TMEL_RS05020	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
TMEL_RS05025	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
TMEL_RS05030	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
TMEL_RS05035	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
TMEL_RS05040	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
TMEL_RS05045	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
TMEL_RS05050	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
TMEL_RS05055	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
TMEL_RS05060	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
TMEL_RS05065	COG1841	ribosomal large subunit assembly
TMEL_RS05070	COG0200	Binds to the 23S rRNA
TMEL_RS05075	COG0201	protein transport
TMEL_RS05080	COG0563	adenylate kinase activity
TMEL_RS05090	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
TMEL_RS05095	COG0257	Belongs to the bacterial ribosomal protein bL36 family
TMEL_RS05100	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
TMEL_RS05105	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
TMEL_RS05110	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
TMEL_RS05115	COG0202	RNA polymerase activity
TMEL_RS05120	COG0203	ribosomal protein L17
TMEL_RS05125	COG0544	peptidyl-prolyl cis-trans isomerase activity
TMEL_RS05130	COG0740	serine-type endopeptidase activity
TMEL_RS05135	COG0217	transcriptional regulatory protein
TMEL_RS05145	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
TMEL_RS05155	COG0564	pseudouridine synthase activity
TMEL_RS05160	COG0174	glutamine synthetase
TMEL_RS05165	COG2342	PFAM TM1410 hypothetical-related protein
TMEL_RS05210	COG1214	PFAM Peptidase M22, glycoprotease
TMEL_RS05215	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
TMEL_RS05220	COG2770	Histidine kinase
TMEL_RS05220	COG3437	response regulator, receiver
TMEL_RS05225	COG2078	PFAM AMMECR1 domain protein
TMEL_RS05240	COG0037	tRNA processing
TMEL_RS05245	COG3681	Belongs to the UPF0597 family
TMEL_RS05255	COG1070	Carbohydrate kinase
TMEL_RS05260	COG1509	lysine 2,3-aminomutase activity
TMEL_RS05270	COG1609	Transcriptional regulator
TMEL_RS05275	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
TMEL_RS05280	COG0395	ABC-type sugar transport system, permease component
TMEL_RS05285	COG1175	transmembrane transport
TMEL_RS05295	COG1653	transport
TMEL_RS05315	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
TMEL_RS05330	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
TMEL_RS05335	COG3481	metal-dependent phosphohydrolase, HD sub domain
TMEL_RS05340	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
TMEL_RS05350	COG0227	Belongs to the bacterial ribosomal protein bL28 family
TMEL_RS05360	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
TMEL_RS05365	COG0358	DNA primase activity
TMEL_RS05375	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
TMEL_RS05380	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
TMEL_RS05385	COG0211	Belongs to the bacterial ribosomal protein bL27 family
TMEL_RS05395	COG0261	This protein binds to 23S rRNA in the presence of protein L20
TMEL_RS05405	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
TMEL_RS05410	COG2176	DNA-directed DNA polymerase activity
TMEL_RS05415	COG2359	stage V sporulation protein S
TMEL_RS05425	COG3872	metal-dependent enzyme
TMEL_RS05430	COG0019	diaminopimelate decarboxylase activity
TMEL_RS05435	COG1473	amidohydrolase
TMEL_RS05440	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
TMEL_RS05445	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
TMEL_RS05450	COG0012	GTP binding
TMEL_RS05455	COG2052	Domain of unknown function (DUF370)
TMEL_RS05460	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TMEL_RS05465	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
TMEL_RS05480	COG0546	phosphoglycolate phosphatase activity
TMEL_RS05485	COG2070	2-Nitropropane dioxygenase
TMEL_RS05525	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
TMEL_RS05530	COG0438	transferase activity, transferring glycosyl groups
TMEL_RS05585	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
TMEL_RS05615	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
TMEL_RS05645	COG2865	translation initiation factor activity
TMEL_RS05805	COG0840	transmembrane signaling receptor activity
TMEL_RS05810	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
TMEL_RS05815	COG0850	regulation of cytokinetic process
TMEL_RS05825	COG1815	bacterial-type flagellum-dependent cell motility
TMEL_RS05835	COG1677	Flagellar hook-basal body complex protein FliE
TMEL_RS05845	COG0443	Heat shock 70 kDa protein
TMEL_RS05850	COG0393	Putative heavy-metal-binding
TMEL_RS05855	COG1073	alpha beta
TMEL_RS05865	COG1131	(ABC) transporter
TMEL_RS05870	COG1725	Transcriptional regulator
TMEL_RS05875	COG0183	Belongs to the thiolase family
TMEL_RS05885	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
TMEL_RS05890	COG1785	Belongs to the alkaline phosphatase family
TMEL_RS05895	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
TMEL_RS05895	COG0493	'glutamate synthase
TMEL_RS05900	COG0543	2 iron, 2 sulfur cluster binding
TMEL_RS05905	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
TMEL_RS05935	COG2201	protein-glutamate methylesterase activity
TMEL_RS05965	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
TMEL_RS05980	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TMEL_RS05985	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
TMEL_RS05990	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
TMEL_RS05995	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
TMEL_RS06005	COG1418	mRNA catabolic process
TMEL_RS06010	COG3842	ATPase activity
TMEL_RS06025	COG1309	transcriptional regulator
TMEL_RS06030	COG0254	rRNA binding
TMEL_RS06035	COG1098	S1 RNA binding domain
TMEL_RS06075	COG0483	inositol monophosphate 1-phosphatase activity
TMEL_RS06080	COG0768	penicillin binding
TMEL_RS06085	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
TMEL_RS06095	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
TMEL_RS06105	COG1610	YqeY-like protein
TMEL_RS06115	COG0698	ribose 5-phosphate isomerase
TMEL_RS06125	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
TMEL_RS06135	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
TMEL_RS06140	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TMEL_RS06140	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TMEL_RS06145	COG0747	negative chemotaxis
TMEL_RS06150	COG0601	transmembrane transport
TMEL_RS06155	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TMEL_RS06160	COG0444	Belongs to the ABC transporter superfamily
TMEL_RS06165	COG4608	Belongs to the ABC transporter superfamily
TMEL_RS06170	COG0540	Belongs to the ATCase OTCase family
TMEL_RS06170	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
TMEL_RS06175	COG2199	diguanylate cyclase activity
TMEL_RS06175	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
TMEL_RS06180	COG0735	belongs to the Fur family
TMEL_RS06185	COG0450	alkyl hydroperoxide reductase
TMEL_RS06190	COG0426	domain, Protein
TMEL_RS06195	COG1528	Iron-storage protein
TMEL_RS06205	COG2033	superoxide reductase activity
TMEL_RS06220	COG3437	response regulator, receiver
TMEL_RS06230	COG1435	thymidine kinase activity
TMEL_RS06235	COG0737	Belongs to the 5'-nucleotidase family
TMEL_RS06245	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
TMEL_RS06250	COG1863	multisubunit Na H antiporter MnhE subunit
TMEL_RS06255	COG2212	antiporter activity
TMEL_RS06270	COG2111	Na H antiporter
TMEL_RS06270	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
TMEL_RS06275	COG1006	Multisubunit Na H antiporter MnhC subunit
TMEL_RS06280	COG0651	ATP synthesis coupled electron transport
TMEL_RS06285	COG2111	Na H antiporter
TMEL_RS06285	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
TMEL_RS06295	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TMEL_RS06300	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TMEL_RS06305	COG0649	NAD binding
TMEL_RS06320	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
TMEL_RS06325	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
TMEL_RS06335	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TMEL_RS06345	COG0446	pyridine nucleotide-disulphide oxidoreductase
TMEL_RS06350	COG1045	serine acetyltransferase
TMEL_RS06355	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
TMEL_RS06360	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
TMEL_RS06365	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
TMEL_RS06370	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
TMEL_RS06375	COG0047	phosphoribosylformylglycinamidine synthase activity
TMEL_RS06380	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
TMEL_RS06395	COG2313	pseudouridylate synthase activity
TMEL_RS06400	COG0622	Phosphoesterase
TMEL_RS06405	COG1739	Uncharacterized protein family UPF0029
TMEL_RS06410	COG0436	Aminotransferase
TMEL_RS06415	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
TMEL_RS06420	COG0640	Transcriptional regulator
TMEL_RS06480	COG0720	synthase
TMEL_RS06485	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
TMEL_RS06510	COG0126	phosphoglycerate kinase activity
TMEL_RS06510	COG0149	triose-phosphate isomerase activity
TMEL_RS06515	COG0126	phosphoglycerate kinase activity
TMEL_RS06520	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
TMEL_RS06535	COG1157	protein secretion by the type III secretion system
TMEL_RS06545	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
TMEL_RS06550	COG0191	fructose-bisphosphate aldolase activity
TMEL_RS06565	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
TMEL_RS06570	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
TMEL_RS06580	COG0233	cytoplasmic translational termination
TMEL_RS06585	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
TMEL_RS06590	COG0575	Belongs to the CDS family
TMEL_RS06595	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
TMEL_RS06600	COG1077	Cell shape determining protein MreB Mrl
TMEL_RS06615	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
TMEL_RS06635	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
TMEL_RS06655	COG1749	Flagellar hook protein flgE
TMEL_RS06660	COG1582	Flagellar protein (FlbD)
TMEL_RS06670	COG1360	Flagellar Motor Protein
TMEL_RS06680	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
TMEL_RS06685	COG1776	CheC inhibitor of MCP methylation
TMEL_RS06685	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
TMEL_RS06690	COG0733	neurotransmitter:sodium symporter activity
TMEL_RS06700	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
TMEL_RS06705	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
TMEL_RS06710	COG2239	Acts as a magnesium transporter
TMEL_RS06720	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
TMEL_RS06725	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
TMEL_RS06740	COG1120	ATPase activity
TMEL_RS06760	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
TMEL_RS06765	COG1490	D-aminoacyl-tRNA deacylase activity
TMEL_RS06770	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
TMEL_RS06785	COG2080	2 iron, 2 sulfur cluster binding
TMEL_RS06785	COG1529	Aldehyde oxidase and xanthine dehydrogenase
TMEL_RS06810	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
TMEL_RS06825	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
TMEL_RS06855	COG0019	diaminopimelate decarboxylase activity
TMEL_RS06870	COG0357	Ribosomal RNA small subunit methyltransferase G
TMEL_RS06875	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
TMEL_RS06915	COG2199	diguanylate cyclase activity
TMEL_RS06915	COG2203	Gaf domain
TMEL_RS06920	COG0584	glycerophosphoryl diester phosphodiesterase
TMEL_RS06925	COG0156	8-amino-7-oxononanoate synthase activity
TMEL_RS06930	COG1063	alcohol dehydrogenase
TMEL_RS06950	COG0534	Mate efflux family protein
TMEL_RS06960	COG1131	(ABC) transporter
TMEL_RS06985	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
TMEL_RS06990	COG1027	Aspartate ammonia-lyase
TMEL_RS06995	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
TMEL_RS07005	COG0142	geranyltranstransferase activity
TMEL_RS07020	COG1078	dGTPase activity
TMEL_RS07025	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
TMEL_RS07050	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
TMEL_RS07055	COG1660	Displays ATPase and GTPase activities
TMEL_RS07060	COG0391	Required for morphogenesis under gluconeogenic growth conditions
TMEL_RS07070	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
TMEL_RS07075	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
TMEL_RS07080	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
TMEL_RS07090	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
TMEL_RS07100	COG1132	(ABC) transporter
TMEL_RS07110	COG0444	Belongs to the ABC transporter superfamily
TMEL_RS07115	COG4608	Belongs to the ABC transporter superfamily
TMEL_RS07125	COG0601	transmembrane transport
TMEL_RS07130	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TMEL_RS07160	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
TMEL_RS07165	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
TMEL_RS07170	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
TMEL_RS07180	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
TMEL_RS07185	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
TMEL_RS07200	COG1752	Esterase of the alpha-beta hydrolase superfamily
TMEL_RS07205	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
TMEL_RS07215	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
TMEL_RS07215	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
TMEL_RS07235	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
TMEL_RS07240	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
TMEL_RS07250	COG0735	belongs to the Fur family
TMEL_RS07255	COG0195	Participates in both transcription termination and antitermination
TMEL_RS07260	COG0779	Required for maturation of 30S ribosomal subunits
TMEL_RS07280	COG0343	queuine tRNA-ribosyltransferase activity
TMEL_RS07290	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
TMEL_RS07295	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
TMEL_RS07300	COG2151	metal-sulfur cluster biosynthetic enzyme
TMEL_RS07305	COG2890	protein-(glutamine-N5) methyltransferase activity
TMEL_RS07310	COG0359	binds to the 23S rRNA
TMEL_RS07315	COG1234	tRNA 3'-trailer cleavage
TMEL_RS07325	COG0617	tRNA 3'-terminal CCA addition
TMEL_RS07325	COG3620	sequence-specific DNA binding
TMEL_RS07325	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
TMEL_RS07360	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
TMEL_RS07365	COG1776	CheC inhibitor of MCP methylation
TMEL_RS07380	COG0455	bacterial-type flagellum organization
TMEL_RS07385	COG1419	protein localization to endoplasmic reticulum
TMEL_RS07390	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
TMEL_RS07590	COG3723	Recombinational DNA repair protein, rece pathway
TMEL_RS07595	COG5377	YqaJ viral recombinase family
TMEL_RS07630	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
TMEL_RS07670	COG0730	response to heat
TMEL_RS07680	COG1774	PSP1 C-terminal conserved region
TMEL_RS07690	COG0802	atpase or kinase
TMEL_RS07695	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
TMEL_RS07700	COG0218	Necessary for normal cell division and for the maintenance of normal septation
TMEL_RS07710	COG5002	protein histidine kinase activity
TMEL_RS07715	COG1639	'signal transduction protein
TMEL_RS07720	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
TMEL_RS07730	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
TMEL_RS07745	COG0820	rRNA (adenine-C2-)-methyltransferase activity
TMEL_RS07755	COG1162	GTPase activity
TMEL_RS07760	COG1032	radical SAM domain protein
TMEL_RS07770	COG0295	cytidine deaminase activity
TMEL_RS07785	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
TMEL_RS07795	COG0557	exoribonuclease II activity
TMEL_RS07800	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
TMEL_RS07800	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
TMEL_RS07805	COG2738	Putative neutral zinc metallopeptidase
TMEL_RS07810	COG0745	RESPONSE REGULATOR receiver
TMEL_RS07815	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
TMEL_RS07820	COG3956	TIGRFAM MazG family protein
TMEL_RS07825	COG0628	permease
TMEL_RS07850	COG0587	DNA-directed DNA polymerase activity
TMEL_RS07855	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
TMEL_RS07860	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
TMEL_RS07865	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
TMEL_RS07870	COG2203	Gaf domain
TMEL_RS07870	COG2199	diguanylate cyclase activity
TMEL_RS07875	COG0812	UDP-N-acetylmuramate dehydrogenase activity
TMEL_RS07880	COG1362	aminopeptidase activity
TMEL_RS07905	COG1482	cell wall glycoprotein biosynthetic process
TMEL_RS07915	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
TMEL_RS07920	COG2255	four-way junction helicase activity
TMEL_RS07925	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
TMEL_RS07935	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
TMEL_RS07940	COG0704	Plays a role in the regulation of phosphate uptake
TMEL_RS07950	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
TMEL_RS07955	COG0138	bifunctional purine biosynthesis protein purh
TMEL_RS07975	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
TMEL_RS07980	COG2894	cell division
TMEL_RS08005	COG0552	protein localization to endoplasmic reticulum
TMEL_RS08015	COG3584	3D domain protein
TMEL_RS08025	COG0482	sulfurtransferase activity
TMEL_RS08030	COG0037	tRNA processing
TMEL_RS08030	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
TMEL_RS08035	COG1316	TRANSCRIPTIONal
TMEL_RS08040	COG1515	deoxyribonuclease V activity
TMEL_RS08055	COG1242	4 iron, 4 sulfur cluster binding
TMEL_RS08060	COG0402	S-adenosylhomocysteine deaminase activity
TMEL_RS08065	COG0799	negative regulation of ribosome biogenesis
TMEL_RS08070	COG0285	dihydrofolate synthase activity
TMEL_RS08075	COG0525	valine-tRNA ligase activity
TMEL_RS08085	COG4656	Part of a membrane complex involved in electron transport
TMEL_RS08090	COG4658	electron transport chain
TMEL_RS08100	COG4660	Part of a membrane complex involved in electron transport
TMEL_RS08105	COG4657	Part of a membrane complex involved in electron transport
TMEL_RS08125	COG0517	IMP dehydrogenase activity
TMEL_RS08125	COG0516	GMP reductase activity
TMEL_RS08130	COG0840	transmembrane signaling receptor activity
TMEL_RS08135	COG0366	Alpha amylase catalytic
TMEL_RS08140	COG1073	alpha beta
TMEL_RS08140	COG2226	methyltransferase
TMEL_RS08145	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
TMEL_RS08150	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
TMEL_RS08155	COG0157	Belongs to the NadC ModD family
TMEL_RS08160	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
TMEL_RS08165	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
TMEL_RS08175	COG1268	BioY protein
TMEL_RS08180	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
TMEL_RS08185	COG1635	Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur
TMEL_RS08195	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
TMEL_RS08205	COG0351	phosphomethylpyrimidine kinase
TMEL_RS08205	COG1992	Thiamine-phosphate synthase
TMEL_RS08210	COG0205	6-phosphofructokinase activity
TMEL_RS08220	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
TMEL_RS08255	COG0571	ribonuclease III activity
TMEL_RS08260	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
TMEL_RS08260	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
TMEL_RS08265	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
TMEL_RS08265	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
TMEL_RS08270	COG0728	peptidoglycan biosynthetic process
TMEL_RS08275	COG2878	Part of a membrane complex involved in electron transport
TMEL_RS08280	COG0758	DNA mediated transformation
TMEL_RS08285	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
TMEL_RS08295	COG1185	polyribonucleotide nucleotidyltransferase activity
TMEL_RS08310	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
TMEL_RS08315	COG1175	transmembrane transport
TMEL_RS08325	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
TMEL_RS08330	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
TMEL_RS08335	COG1366	Belongs to the anti-sigma-factor antagonist family
TMEL_RS08340	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
TMEL_RS08345	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
TMEL_RS08345	COG0539	negative regulation of cytoplasmic translation
TMEL_RS08350	COG1160	GTP binding
TMEL_RS08355	COG1744	ABC transporter substrate-binding protein PnrA-like
TMEL_RS08370	COG0230	Belongs to the bacterial ribosomal protein bL34 family
TMEL_RS08375	COG0594	ribonuclease P activity
TMEL_RS08380	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
TMEL_RS08385	COG0706	membrane insertase activity
TMEL_RS08390	COG1847	R3H domain protein
TMEL_RS08400	COG0569	domain protein
TMEL_RS08400	COG2985	domain, Protein
TMEL_RS08405	COG0174	glutamine synthetase
TMEL_RS08410	COG2199	diguanylate cyclase activity
TMEL_RS08410	COG2203	Gaf domain
TMEL_RS08420	COG2723	6-phospho-beta-galactosidase activity
TMEL_RS08470	COG1132	(ABC) transporter
TMEL_RS08485	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
TMEL_RS08490	COG1518	maintenance of DNA repeat elements
TMEL_RS08495	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
TMEL_RS08535	COG3337	CRISPR-associated protein (Cas_Cmr5)
TMEL_RS08570	COG1353	crispr-associated protein
TMEL_RS08580	COG1337	RAMP superfamily
TMEL_RS08630	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
TMEL_RS08645	COG0556	nucleotide-excision repair
TMEL_RS08655	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
TMEL_RS08670	COG2189	Belongs to the N(4) N(6)-methyltransferase family
TMEL_RS08685	COG2361	Protein of unknown function DUF86
TMEL_RS08700	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
TMEL_RS08710	COG0438	transferase activity, transferring glycosyl groups
TMEL_RS08715	COG3842	ATPase activity
TMEL_RS08780	COG3842	ATPase activity
TMEL_RS08785	COG0438	transferase activity, transferring glycosyl groups
TMEL_RS08800	COG0730	response to heat
TMEL_RS08805	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
TMEL_RS08820	COG0768	penicillin binding
TMEL_RS08830	COG0275	rRNA processing
TMEL_RS08840	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
TMEL_RS08850	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
TMEL_RS08855	COG4608	Belongs to the ABC transporter superfamily
TMEL_RS08865	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TMEL_RS08870	COG0601	transmembrane transport
TMEL_RS08875	COG0322	excinuclease ABC activity
TMEL_RS08885	COG0509	glycine decarboxylation via glycine cleavage system
TMEL_RS08890	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
TMEL_RS08890	COG1918	ferrous iron import across plasma membrane
TMEL_RS08905	COG1596	polysaccharide export
TMEL_RS08905	COG1555	photosystem II stabilization
TMEL_RS08915	COG4796	Type ii and iii secretion system protein
TMEL_RS08945	COG1459	type II secretion system
TMEL_RS08950	COG1122	ATPase activity
TMEL_RS08955	COG2813	Specifically methylates the guanine in position
TMEL_RS08965	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
TMEL_RS08975	COG0268	Binds directly to 16S ribosomal RNA
TMEL_RS08980	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
TMEL_RS08995	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
TMEL_RS09000	COG1923	regulation of RNA biosynthetic process
TMEL_RS09015	COG0572	uridine kinase
TMEL_RS09020	COG1530	ribonuclease E activity
TMEL_RS09025	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
TMEL_RS09035	COG1013	pyruvate-flavodoxin oxidoreductase activity
TMEL_RS09050	COG2201	protein-glutamate methylesterase activity
TMEL_RS09080	COG0840	transmembrane signaling receptor activity
TMEL_RS09085	COG2986	histidine ammonia-lyase
TMEL_RS09125	COG1363	Peptidase, m42
TMEL_RS09150	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
TMEL_RS09155	COG0220	tRNA (guanine-N7-)-methyltransferase activity
TMEL_RS09165	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
TMEL_RS09165	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
TMEL_RS09175	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
TMEL_RS09185	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TMEL_RS09190	COG0058	SHG alpha-glucan phosphorylase activity
TMEL_RS09195	COG0681	Belongs to the peptidase S26 family
TMEL_RS09200	COG0335	large ribosomal subunit rRNA binding
TMEL_RS09205	COG4752	Belongs to the RNA methyltransferase TrmD family
TMEL_RS09210	COG0336	Belongs to the RNA methyltransferase TrmD family
TMEL_RS09215	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
TMEL_RS09220	COG1837	Belongs to the UPF0109 family
TMEL_RS09225	COG0228	four-way junction DNA binding
TMEL_RS09230	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
TMEL_RS09240	COG1176	ABC-type spermidine putrescine transport system, permease component I
TMEL_RS09255	COG1059	Responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine 7-oxoG) from DNA. Also nicks DNA at apurinic apyrimidinic sites (AP sites)
TMEL_RS09270	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
TMEL_RS09280	COG0840	transmembrane signaling receptor activity
TMEL_RS09300	COG1653	transport
TMEL_RS09305	COG0438	transferase activity, transferring glycosyl groups
TMEL_RS09315	COG5002	protein histidine kinase activity
TMEL_RS09320	COG0745	RESPONSE REGULATOR receiver
TMEL_RS09325	COG0704	Plays a role in the regulation of phosphate uptake
TMEL_RS09330	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
TMEL_RS09335	COG0573	inorganic phosphate transmembrane transporter activity
TMEL_RS09350	COG1012	belongs to the aldehyde dehydrogenase family
TMEL_RS09355	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
TMEL_RS09360	COG1846	Transcriptional regulator
TMEL_RS09370	COG1105	Belongs to the carbohydrate kinase PfkB family
TMEL_RS09375	COG1028	Short-chain dehydrogenase reductase Sdr
TMEL_RS09380	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
TMEL_RS09385	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
TMEL_RS09390	COG0745	RESPONSE REGULATOR receiver
TMEL_RS09410	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
TMEL_RS09415	COG0166	Belongs to the GPI family
TMEL_RS09425	COG0237	dephospho-CoA kinase activity
TMEL_RS09430	COG2199	diguanylate cyclase activity
TMEL_RS09435	COG0556	nucleotide-excision repair
TMEL_RS09440	COG1293	RNA-binding protein homologous to eukaryotic snRNP
TMEL_RS09475	COG1323	Belongs to the UPF0348 family
TMEL_RS09480	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
TMEL_RS09490	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
TMEL_RS09495	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
TMEL_RS09505	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
TMEL_RS09505	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
TMEL_RS09510	COG0235	Class ii aldolase
TMEL_RS09520	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
TMEL_RS09520	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
TMEL_RS09530	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
TMEL_RS09540	COG0840	transmembrane signaling receptor activity
TMEL_RS09540	COG3290	protein histidine kinase activity
TMEL_RS09555	COG0045	succinate-CoA ligase (ADP-forming) activity
TMEL_RS09565	COG2985	domain, Protein
TMEL_RS09565	COG0569	domain protein
TMEL_RS09570	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
TMEL_RS09580	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
TMEL_RS09585	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
TMEL_RS09590	COG2171	N-acyltransferase activity
TMEL_RS09600	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
TMEL_RS09610	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
TMEL_RS09615	COG0815	Transfers the fatty acyl group on membrane lipoproteins
TMEL_RS09630	COG0404	The glycine cleavage system catalyzes the degradation of glycine
TMEL_RS09635	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
TMEL_RS09640	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
TMEL_RS09645	COG1454	alcohol dehydrogenase
TMEL_RS09665	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
TMEL_RS09670	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
TMEL_RS09685	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
TMEL_RS09685	COG0674	pyruvate-flavodoxin oxidoreductase activity
TMEL_RS09690	COG1144	Oxidoreductase
TMEL_RS09695	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
TMEL_RS09700	COG0470	DNA polymerase III
TMEL_RS09705	COG1122	ATPase activity
TMEL_RS09710	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
TMEL_RS09725	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
TMEL_RS09730	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
TMEL_RS09735	COG1862	Preprotein translocase
TMEL_RS09740	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
TMEL_RS09750	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
TMEL_RS09755	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
TMEL_RS09770	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
TMEL_RS09785	COG1570	exodeoxyribonuclease VII activity
TMEL_RS09790	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
TMEL_RS09790	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
TMEL_RS09805	COG1193	negative regulation of DNA recombination
TMEL_RS09815	COG0306	phosphate transporter
TMEL_RS09830	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
TMEL_RS09845	COG0280	phosphate acetyltransferase
TMEL_RS09870	COG1131	(ABC) transporter
TMEL_RS09875	COG0667	Aldo Keto reductase
TMEL_RS09880	COG4989	oxidoreductase activity
TMEL_RS09900	COG1414	Transcriptional regulator
TMEL_RS09915	COG2199	diguanylate cyclase activity
TMEL_RS09915	COG2203	Gaf domain
TMEL_RS09930	COG0840	transmembrane signaling receptor activity
TMEL_RS09960	COG1363	Peptidase, m42
TMEL_RS10000	COG2199	diguanylate cyclase activity
TMEL_RS10000	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain