locus-tag	class	description
AXH83_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
AXH83_RS00010	COG0592	DNA-directed DNA polymerase activity
AXH83_RS00015	COG0187	DNA topoisomerase II activity
AXH83_RS00020	COG0154	amidase activity
AXH83_RS00025	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AXH83_RS00030	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AXH83_RS00040	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
AXH83_RS00045	COG0004	ammonium transporteR
AXH83_RS00065	COG0067	glutamate synthase
AXH83_RS00075	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
AXH83_RS00080	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
AXH83_RS00090	COG0674	pyruvate-flavodoxin oxidoreductase activity
AXH83_RS00095	COG1013	pyruvate-flavodoxin oxidoreductase activity
AXH83_RS00105	COG0589	response to stress
AXH83_RS00110	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
AXH83_RS00125	COG0750	zinc metalloprotease
AXH83_RS00130	COG1278	Cold shock
AXH83_RS00140	COG3328	transposase activity
AXH83_RS00155	COG0633	Ferredoxin
AXH83_RS00160	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
AXH83_RS00170	COG0778	Nitroreductase
AXH83_RS00170	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
AXH83_RS00190	COG0116	Belongs to the methyltransferase superfamily
AXH83_RS00200	COG2252	PERMEase
AXH83_RS00215	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
AXH83_RS00220	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
AXH83_RS00225	COG2204	response regulator
AXH83_RS00230	COG5000	phosphorelay sensor kinase activity
AXH83_RS00240	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
AXH83_RS00270	COG1458	PINc domain ribonuclease
AXH83_RS00275	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
AXH83_RS00300	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
AXH83_RS00305	COG2226	methyltransferase
AXH83_RS00320	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
AXH83_RS00340	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
AXH83_RS00345	COG3264	Mechanosensitive ion channel
AXH83_RS00345	COG1196	nuclear chromosome segregation
AXH83_RS00350	COG0653	protein targeting
AXH83_RS00355	COG1994	Peptidase M50
AXH83_RS00360	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
AXH83_RS00365	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
AXH83_RS00370	COG4974	Belongs to the 'phage' integrase family
AXH83_RS00375	COG0194	GDP metabolic process
AXH83_RS00380	COG1561	YicC-like family, N-terminal region
AXH83_RS00385	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AXH83_RS00395	COG0243	molybdopterin cofactor binding
AXH83_RS00410	COG0348	domain, Protein
AXH83_RS00415	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
AXH83_RS00425	COG0315	cyclic pyranopterin monophosphate synthase activity
AXH83_RS00425	COG0521	Mo-molybdopterin cofactor biosynthetic process
AXH83_RS00430	COG0746	molybdenum cofactor guanylyltransferase activity
AXH83_RS00440	COG4149	molybdate abc transporter
AXH83_RS00445	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
AXH83_RS00465	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
AXH83_RS00470	COG4974	Belongs to the 'phage' integrase family
AXH83_RS00480	COG0585	pseudouridine synthase activity
AXH83_RS00485	COG0306	phosphate transporter
AXH83_RS00490	COG1392	Phosphate transport regulator
AXH83_RS00495	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AXH83_RS00500	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
AXH83_RS00505	COG0217	transcriptional regulatory protein
AXH83_RS00520	COG0779	Required for maturation of 30S ribosomal subunits
AXH83_RS00525	COG0195	Participates in both transcription termination and antitermination
AXH83_RS00535	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
AXH83_RS00535	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
AXH83_RS00540	COG1550	Protein conserved in bacteria
AXH83_RS00545	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
AXH83_RS00550	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
AXH83_RS00555	COG1024	Enoyl-CoA hydratase
AXH83_RS00560	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AXH83_RS00565	COG1271	oxidase subunit
AXH83_RS00570	COG1294	oxidase, subunit
AXH83_RS00590	COG1396	sequence-specific DNA binding
AXH83_RS00595	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
AXH83_RS00605	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
AXH83_RS00610	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
AXH83_RS00620	COG0357	Ribosomal RNA small subunit methyltransferase G
AXH83_RS00625	COG1851	Uncharacterised protein family (UPF0128)
AXH83_RS00630	COG1332	CRISPR-associated RAMP protein, Csm5 family
AXH83_RS00635	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AXH83_RS00655	COG4822	anaerobic cobalamin biosynthetic process
AXH83_RS00660	COG1131	(ABC) transporter
AXH83_RS00665	COG0842	Transport permease protein
AXH83_RS00670	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AXH83_RS00675	COG1120	ATPase activity
AXH83_RS00680	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
AXH83_RS00685	COG1648	precorrin-2 dehydrogenase activity
AXH83_RS00685	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AXH83_RS00705	COG0358	DNA primase activity
AXH83_RS00710	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AXH83_RS00745	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
AXH83_RS00750	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
AXH83_RS00760	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
AXH83_RS00765	COG0006	proline dipeptidase activity
AXH83_RS00775	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
AXH83_RS00780	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
AXH83_RS00795	COG2003	Belongs to the UPF0758 family
AXH83_RS00800	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
AXH83_RS00805	COG0706	membrane insertase activity
AXH83_RS00810	COG0594	ribonuclease P activity
AXH83_RS00835	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
AXH83_RS00840	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
AXH83_RS00850	COG1012	belongs to the aldehyde dehydrogenase family
AXH83_RS00860	COG1309	transcriptional regulator
AXH83_RS00865	COG1024	Enoyl-CoA hydratase
AXH83_RS00865	COG1250	3-hydroxyacyl-CoA dehydrogenase
AXH83_RS00870	COG0183	Belongs to the thiolase family
AXH83_RS00875	COG1960	acyl-CoA dehydrogenase activity
AXH83_RS00885	COG0318	PFAM AMP-dependent synthetase and ligase
AXH83_RS00910	COG1012	belongs to the aldehyde dehydrogenase family
AXH83_RS00920	COG0318	PFAM AMP-dependent synthetase and ligase
AXH83_RS00925	COG0318	PFAM AMP-dependent synthetase and ligase
AXH83_RS00945	COG0248	Ppx GppA phosphatase
AXH83_RS00955	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AXH83_RS00960	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AXH83_RS00965	COG1333	cytochrome c biogenesis protein
AXH83_RS00975	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
AXH83_RS00980	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
AXH83_RS00990	COG4956	integral membrane protein (PIN domain superfamily)
AXH83_RS00995	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
AXH83_RS00995	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
AXH83_RS01000	COG2203	Gaf domain
AXH83_RS01000	COG3706	GGDEF domain
AXH83_RS01000	COG4251	negative regulation of phosphorylation
AXH83_RS01000	COG5001	Diguanylate cyclase
AXH83_RS01010	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AXH83_RS01015	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AXH83_RS01025	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
AXH83_RS01035	COG1034	ATP synthesis coupled electron transport
AXH83_RS01040	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
AXH83_RS01045	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AXH83_RS01050	COG0839	Belongs to the complex I subunit 6 family
AXH83_RS01070	COG1007	ATP synthesis coupled electron transport
AXH83_RS01080	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
AXH83_RS01130	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AXH83_RS01165	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AXH83_RS01175	COG1918	ferrous iron import across plasma membrane
AXH83_RS01175	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
AXH83_RS01185	COG2226	methyltransferase
AXH83_RS01195	COG4771	TonB-dependent receptor
AXH83_RS01230	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
AXH83_RS01265	COG0701	Predicted permease
AXH83_RS01275	COG2095	MarC family integral membrane protein
AXH83_RS01310	COG0438	transferase activity, transferring glycosyl groups
AXH83_RS01330	COG0457	Tetratricopeptide repeat
AXH83_RS01340	COG0529	Catalyzes the synthesis of activated sulfate
AXH83_RS01345	COG2895	sulfate adenylyltransferase (ATP) activity
AXH83_RS01350	COG0175	sulfate reduction
AXH83_RS01355	COG0529	Catalyzes the synthesis of activated sulfate
AXH83_RS01390	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
AXH83_RS01395	COG0163	prenyltransferase activity
AXH83_RS01410	COG1496	oxidoreductase activity
AXH83_RS01420	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
AXH83_RS01425	COG0505	Belongs to the CarA family
AXH83_RS01430	COG0406	alpha-ribazole phosphatase activity
AXH83_RS01435	COG0291	Belongs to the bacterial ribosomal protein bL35 family
AXH83_RS01440	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
AXH83_RS01445	COG0569	domain protein
AXH83_RS01450	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
AXH83_RS01455	COG0072	phenylalanine-tRNA ligase activity
AXH83_RS01465	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AXH83_RS01470	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
AXH83_RS01480	COG0848	biopolymer transport protein
AXH83_RS01485	COG0811	peptide transport
AXH83_RS01495	COG1047	Peptidyl-prolyl cis-trans
AXH83_RS01500	COG0733	neurotransmitter:sodium symporter activity
AXH83_RS01515	COG0585	pseudouridine synthase activity
AXH83_RS01530	COG0628	permease
AXH83_RS01540	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
AXH83_RS01545	COG0574	Belongs to the PEP-utilizing enzyme family
AXH83_RS01545	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AXH83_RS01560	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
AXH83_RS01565	COG0318	PFAM AMP-dependent synthetase and ligase
AXH83_RS01575	COG0632	four-way junction helicase activity
AXH83_RS01580	COG2255	four-way junction helicase activity
AXH83_RS01585	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
AXH83_RS01590	COG0343	queuine tRNA-ribosyltransferase activity
AXH83_RS01595	COG5001	Diguanylate cyclase
AXH83_RS01595	COG3300	MHYT domain
AXH83_RS01600	COG0756	dUTP diphosphatase activity
AXH83_RS01610	COG3852	Histidine kinase
AXH83_RS01620	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
AXH83_RS01625	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
AXH83_RS01625	COG1773	rubredoxin
AXH83_RS01635	COG0438	transferase activity, transferring glycosyl groups
AXH83_RS01645	COG0463	Glycosyl transferase, family 2
AXH83_RS01645	COG1216	Glycosyl transferase, family 2
AXH83_RS01660	COG1959	2 iron, 2 sulfur cluster binding
AXH83_RS01660	COG1295	ribonuclease BN
AXH83_RS01665	COG0446	pyridine nucleotide-disulphide oxidoreductase
AXH83_RS01670	COG2239	Acts as a magnesium transporter
AXH83_RS01675	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
AXH83_RS01680	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
AXH83_RS01690	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
AXH83_RS01695	COG0840	transmembrane signaling receptor activity
AXH83_RS01700	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
AXH83_RS01705	COG1797	cobyrinic acid a,c-diamide synthase activity
AXH83_RS01715	COG2033	superoxide reductase activity
AXH83_RS01720	COG0426	domain, Protein
AXH83_RS01725	COG0450	alkyl hydroperoxide reductase
AXH83_RS01770	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AXH83_RS01780	COG0242	peptide deformylase activity
AXH83_RS01785	COG0254	rRNA binding
AXH83_RS01790	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
AXH83_RS01795	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
AXH83_RS01800	COG0776	regulation of translation
AXH83_RS01805	COG0658	competence protein
AXH83_RS01805	COG2333	competence protein COMEC
AXH83_RS01810	COG0180	Tryptophanyl-tRNA synthetase
AXH83_RS01815	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AXH83_RS01820	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
AXH83_RS01825	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
AXH83_RS01830	COG0277	FAD linked oxidase domain protein
AXH83_RS01840	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
AXH83_RS01855	COG0443	Heat shock 70 kDa protein
AXH83_RS01860	COG0484	heat shock protein binding
AXH83_RS01865	COG0789	Transcriptional regulator
AXH83_RS01870	COG0542	response to heat
AXH83_RS01875	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AXH83_RS01900	COG4796	Type ii and iii secretion system protein
AXH83_RS01915	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AXH83_RS01920	COG1459	type II secretion system
AXH83_RS01925	COG1322	Protein conserved in bacteria
AXH83_RS01935	COG0803	Belongs to the bacterial solute-binding protein 9 family
AXH83_RS01940	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
AXH83_RS01945	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
AXH83_RS01950	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
AXH83_RS01965	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
AXH83_RS01970	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
AXH83_RS01975	COG1960	acyl-CoA dehydrogenase activity
AXH83_RS01980	COG0518	GMP synthase (glutamine-hydrolyzing) activity
AXH83_RS01980	COG0519	Catalyzes the synthesis of GMP from XMP
AXH83_RS01990	COG0335	large ribosomal subunit rRNA binding
AXH83_RS01995	COG4752	Belongs to the RNA methyltransferase TrmD family
AXH83_RS02000	COG0336	Belongs to the RNA methyltransferase TrmD family
AXH83_RS02010	COG1837	Belongs to the UPF0109 family
AXH83_RS02015	COG0228	four-way junction DNA binding
AXH83_RS02020	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
AXH83_RS02035	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AXH83_RS02040	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AXH83_RS02045	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AXH83_RS02050	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AXH83_RS02055	COG1862	Preprotein translocase
AXH83_RS02060	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AXH83_RS02065	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AXH83_RS02080	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
AXH83_RS02085	COG0242	peptide deformylase activity
AXH83_RS02090	COG2716	regulation of RNA biosynthetic process
AXH83_RS02095	COG1752	Esterase of the alpha-beta hydrolase superfamily
AXH83_RS02120	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AXH83_RS02125	COG1414	Transcriptional regulator
AXH83_RS02135	COG0530	calcium, potassium:sodium antiporter activity
AXH83_RS02145	COG0483	inositol monophosphate 1-phosphatase activity
AXH83_RS02150	COG1530	ribonuclease E activity
AXH83_RS02160	COG1136	(ABC) transporter
AXH83_RS02165	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
AXH83_RS02175	COG1774	PSP1 C-terminal conserved region
AXH83_RS02180	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AXH83_RS02180	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AXH83_RS02185	COG0084	hydrolase, TatD family'
AXH83_RS02190	COG1414	Transcriptional regulator
AXH83_RS02220	COG1127	ABC transporter
AXH83_RS02225	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
AXH83_RS02235	COG0509	glycine decarboxylation via glycine cleavage system
AXH83_RS02240	COG0617	tRNA 3'-terminal CCA addition
AXH83_RS02245	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
AXH83_RS02260	COG1137	ATPase activity
AXH83_RS02265	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
AXH83_RS02275	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AXH83_RS02275	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
AXH83_RS02275	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
AXH83_RS02280	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
AXH83_RS02285	COG1660	Displays ATPase and GTPase activities
AXH83_RS02290	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
AXH83_RS02300	COG1185	polyribonucleotide nucleotidyltransferase activity
AXH83_RS02305	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
AXH83_RS02335	COG0745	RESPONSE REGULATOR receiver
AXH83_RS02340	COG5002	protein histidine kinase activity
AXH83_RS02350	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
AXH83_RS02355	COG1960	acyl-CoA dehydrogenase activity
AXH83_RS02360	COG1960	acyl-CoA dehydrogenase activity
AXH83_RS02375	COG1132	(ABC) transporter
AXH83_RS02380	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AXH83_RS02390	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AXH83_RS02395	COG3494	Protein of unknown function (DUF1009)
AXH83_RS02405	COG0174	glutamine synthetase
AXH83_RS02410	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AXH83_RS02420	COG1674	ftsk spoiiie
AXH83_RS02425	COG1980	fructose-bisphosphate aldolase activity
AXH83_RS02430	COG1940	carbohydrate kinase activity
AXH83_RS02440	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
AXH83_RS02445	COG1872	DUF167
AXH83_RS02455	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
AXH83_RS02460	COG0741	lytic transglycosylase activity
AXH83_RS02460	COG1388	LysM domain
AXH83_RS02475	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
AXH83_RS02585	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
AXH83_RS02590	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
AXH83_RS02595	COG1592	Rubrerythrin
AXH83_RS02610	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AXH83_RS02615	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
AXH83_RS02620	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AXH83_RS02625	COG1144	Oxidoreductase
AXH83_RS02640	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
AXH83_RS02670	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AXH83_RS02680	COG0709	Synthesizes selenophosphate from selenide and ATP
AXH83_RS02685	COG1051	belongs to the nudix hydrolase family
AXH83_RS02685	COG1056	cytidyltransferase-related domain
AXH83_RS02690	COG1546	Belongs to the CinA family
AXH83_RS02690	COG1058	Belongs to the CinA family
AXH83_RS02695	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
AXH83_RS02700	COG0232	Belongs to the dGTPase family. Type 2 subfamily
AXH83_RS02705	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
AXH83_RS02710	COG0330	HflC and HflK could
AXH83_RS02720	COG0356	it plays a direct role in the translocation of protons across the membrane
AXH83_RS02725	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AXH83_RS02735	COG0347	Belongs to the P(II) protein family
AXH83_RS02740	COG0698	ribose 5-phosphate isomerase
AXH83_RS02745	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
AXH83_RS02750	COG2131	deaminase
AXH83_RS02755	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
AXH83_RS02760	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AXH83_RS02765	COG4536	flavin adenine dinucleotide binding
AXH83_RS02770	COG0010	Belongs to the arginase family
AXH83_RS02775	COG1242	4 iron, 4 sulfur cluster binding
AXH83_RS02785	COG0601	transmembrane transport
AXH83_RS02790	COG0261	This protein binds to 23S rRNA in the presence of protein L20
AXH83_RS02795	COG0211	Belongs to the bacterial ribosomal protein bL27 family
AXH83_RS02800	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
AXH83_RS02810	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
AXH83_RS02820	COG0799	negative regulation of ribosome biogenesis
AXH83_RS02830	COG1459	type II secretion system
AXH83_RS02835	COG0730	response to heat
AXH83_RS02840	COG0316	Belongs to the HesB IscA family
AXH83_RS02840	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
AXH83_RS02845	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AXH83_RS02865	COG3706	GGDEF domain
AXH83_RS02875	COG2385	sporulation resulting in formation of a cellular spore
AXH83_RS02880	COG3103	Sh3 type 3 domain protein
AXH83_RS02880	COG0366	Alpha amylase catalytic
AXH83_RS02910	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
AXH83_RS02920	COG3706	GGDEF domain
AXH83_RS02930	COG0752	glycyl-tRNA synthetase alpha subunit
AXH83_RS02935	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
AXH83_RS02940	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AXH83_RS02955	COG0726	polysaccharide deacetylase
AXH83_RS02960	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
AXH83_RS02970	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AXH83_RS02975	COG0285	dihydrofolate synthase activity
AXH83_RS02980	COG0280	phosphate acetyltransferase
AXH83_RS02980	COG0281	malic enzyme
AXH83_RS02985	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
AXH83_RS02990	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
AXH83_RS03000	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AXH83_RS03000	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
AXH83_RS03005	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
AXH83_RS03010	COG1127	ABC transporter
AXH83_RS03030	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
AXH83_RS03050	COG1254	Belongs to the acylphosphatase family
AXH83_RS03055	COG1063	alcohol dehydrogenase
AXH83_RS03060	COG0631	protein serine/threonine phosphatase activity
AXH83_RS03065	COG1105	Belongs to the carbohydrate kinase PfkB family
AXH83_RS03070	COG1509	lysine 2,3-aminomutase activity
AXH83_RS03080	COG4786	Flagellar basal body rod
AXH83_RS03085	COG4786	Flagellar basal body rod
AXH83_RS03095	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
AXH83_RS03100	COG1706	bacterial-type flagellum-dependent cell motility
AXH83_RS03125	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AXH83_RS03130	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
AXH83_RS03135	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
AXH83_RS03145	COG3118	belongs to the thioredoxin family
AXH83_RS03155	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
AXH83_RS03185	COG0438	transferase activity, transferring glycosyl groups
AXH83_RS03195	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
AXH83_RS03200	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
AXH83_RS03235	COG0728	peptidoglycan biosynthetic process
AXH83_RS03250	COG1815	bacterial-type flagellum-dependent cell motility
AXH83_RS03260	COG1677	Flagellar hook-basal body complex protein FliE
AXH83_RS03265	COG1766	The M ring may be actively involved in energy transduction
AXH83_RS03270	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
AXH83_RS03280	COG1157	protein secretion by the type III secretion system
AXH83_RS03305	COG1749	Flagellar hook protein flgE
AXH83_RS03320	COG1360	Flagellar Motor Protein
AXH83_RS03325	COG1580	Controls the rotational direction of flagella during chemotaxis
AXH83_RS03340	COG1338	Plays a role in the flagellum-specific transport system
AXH83_RS03345	COG1987	bacterial-type flagellum assembly
AXH83_RS03355	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
AXH83_RS03360	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
AXH83_RS03365	COG1419	protein localization to endoplasmic reticulum
AXH83_RS03385	COG2201	protein-glutamate methylesterase activity
AXH83_RS03390	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
AXH83_RS03395	COG1776	CheC inhibitor of MCP methylation
AXH83_RS03395	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
AXH83_RS03400	COG1396	sequence-specific DNA binding
AXH83_RS03400	COG1917	Cupin 2, conserved barrel domain protein
AXH83_RS03405	COG0183	Belongs to the thiolase family
AXH83_RS03410	COG1250	3-hydroxyacyl-CoA dehydrogenase
AXH83_RS03415	COG1024	Enoyl-CoA hydratase
AXH83_RS03420	COG1960	acyl-CoA dehydrogenase activity
AXH83_RS03430	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
AXH83_RS03435	COG0247	lactate metabolic process
AXH83_RS03435	COG2181	nitrate reductase activity
AXH83_RS03450	COG0037	tRNA processing
AXH83_RS03470	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
AXH83_RS03480	COG1121	(ABC) transporter
AXH83_RS03485	COG0142	geranyltranstransferase activity
AXH83_RS03490	COG2078	PFAM AMMECR1 domain protein
AXH83_RS03500	COG0564	pseudouridine synthase activity
AXH83_RS03510	COG3706	GGDEF domain
AXH83_RS03515	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AXH83_RS03525	COG0617	tRNA 3'-terminal CCA addition
AXH83_RS03525	COG3620	sequence-specific DNA binding
AXH83_RS03525	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
AXH83_RS03535	COG0436	Aminotransferase
AXH83_RS03550	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AXH83_RS03555	COG1151	hydroxylamine reductase activity
AXH83_RS03570	COG1285	pathogenesis
AXH83_RS03580	COG0227	Belongs to the bacterial ribosomal protein bL28 family
AXH83_RS03585	COG2203	Gaf domain
AXH83_RS03585	COG2199	diguanylate cyclase activity
AXH83_RS03595	COG0720	synthase
AXH83_RS03605	COG0436	Aminotransferase
AXH83_RS03610	COG0493	'glutamate synthase
AXH83_RS03615	COG0543	2 iron, 2 sulfur cluster binding
AXH83_RS03620	COG0741	lytic transglycosylase activity
AXH83_RS03620	COG1388	LysM domain
AXH83_RS03640	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
AXH83_RS03645	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
AXH83_RS03650	COG1418	mRNA catabolic process
AXH83_RS03655	COG1692	metallophosphoesterase
AXH83_RS03660	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
AXH83_RS03665	COG1570	exodeoxyribonuclease VII activity
AXH83_RS03690	COG1059	Responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine 7-oxoG) from DNA. Also nicks DNA at apurinic apyrimidinic sites (AP sites)
AXH83_RS03700	COG1489	DNA binding
AXH83_RS03705	COG1355	regulation of microtubule-based process
AXH83_RS03730	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
AXH83_RS03735	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
AXH83_RS03745	COG1301	dicarboxylic acid transport
AXH83_RS03755	COG1028	Short-chain dehydrogenase reductase Sdr
AXH83_RS03770	COG0352	thiamine-phosphate diphosphorylase activity
AXH83_RS03775	COG1635	Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur
AXH83_RS03780	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
AXH83_RS03790	COG2977	Belongs to the P-Pant transferase superfamily
AXH83_RS03815	COG3437	response regulator, receiver
AXH83_RS03870	COG1595	DNA-templated transcription, initiation
AXH83_RS03885	COG1404	Belongs to the peptidase S8 family
AXH83_RS03890	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
AXH83_RS03895	COG1993	acr, cog1993
AXH83_RS03915	COG0390	transport system, permease component
AXH83_RS03970	COG3328	transposase activity
AXH83_RS03980	COG1830	Aldolase
AXH83_RS03985	COG0493	'glutamate synthase
AXH83_RS03995	COG1396	sequence-specific DNA binding
AXH83_RS04000	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AXH83_RS04010	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
AXH83_RS04015	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
AXH83_RS04025	COG3328	transposase activity
AXH83_RS04035	COG0714	Associated with various cellular activities
AXH83_RS04040	COG2204	response regulator
AXH83_RS04045	COG4191	Histidine kinase
AXH83_RS04050	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AXH83_RS04055	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AXH83_RS04090	COG0113	porphobilinogen synthase activity
AXH83_RS04120	COG2009	succinate dehydrogenase
AXH83_RS04135	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
AXH83_RS04140	COG0045	succinate-CoA ligase (ADP-forming) activity
AXH83_RS04145	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
AXH83_RS04155	COG0674	pyruvate-flavodoxin oxidoreductase activity
AXH83_RS04155	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
AXH83_RS04160	COG1013	pyruvate-flavodoxin oxidoreductase activity
AXH83_RS04170	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
AXH83_RS04175	COG0481	GTPase activity
AXH83_RS04180	COG0681	Belongs to the peptidase S26 family
AXH83_RS04210	COG1475	DNA binding
AXH83_RS04215	COG1979	alcohol dehydrogenase
AXH83_RS04225	COG1110	DNA topoisomerase II activity
AXH83_RS04230	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
AXH83_RS04245	COG0602	queuosine metabolic process
AXH83_RS04250	COG0210	DNA helicase
AXH83_RS04270	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
AXH83_RS04280	COG0860	N-Acetylmuramoyl-L-alanine amidase
AXH83_RS04285	COG0196	riboflavin kinase activity
AXH83_RS04290	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
AXH83_RS04295	COG1959	2 iron, 2 sulfur cluster binding
AXH83_RS04300	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
AXH83_RS04305	COG0745	RESPONSE REGULATOR receiver
AXH83_RS04310	COG2198	Histidine kinase
AXH83_RS04310	COG0784	Response regulator, receiver
AXH83_RS04310	COG0643	Histidine kinase
AXH83_RS04315	COG0835	chemotaxis
AXH83_RS04320	COG0835	chemotaxis
AXH83_RS04320	COG0784	Response regulator, receiver
AXH83_RS04325	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
AXH83_RS04330	COG0606	chelatase, subunit chli
AXH83_RS04340	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
AXH83_RS04345	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
AXH83_RS04350	COG0438	transferase activity, transferring glycosyl groups
AXH83_RS04375	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
AXH83_RS04380	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AXH83_RS04385	COG0124	histidyl-tRNA synthetase
AXH83_RS04400	COG1024	Enoyl-CoA hydratase
AXH83_RS04430	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
AXH83_RS04430	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
AXH83_RS04435	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
AXH83_RS04440	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AXH83_RS04445	COG1067	ATP-dependent peptidase activity
AXH83_RS04450	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
AXH83_RS04460	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
AXH83_RS04465	COG0785	Cytochrome C biogenesis protein
AXH83_RS04470	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AXH83_RS04480	COG0215	cysteine-tRNA ligase activity
AXH83_RS04490	COG0432	Pfam Uncharacterised protein family UPF0047
AXH83_RS04495	COG3956	TIGRFAM MazG family protein
AXH83_RS04515	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
AXH83_RS04525	COG0355	proton-transporting ATP synthase activity, rotational mechanism
AXH83_RS04530	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
AXH83_RS04535	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
AXH83_RS04540	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
AXH83_RS04545	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
AXH83_RS04550	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
AXH83_RS04555	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
AXH83_RS04560	COG1475	DNA binding
AXH83_RS04565	COG1192	Involved in chromosome partitioning
AXH83_RS04575	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
AXH83_RS04580	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AXH83_RS04585	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
AXH83_RS04590	COG0540	Belongs to the ATCase OTCase family
AXH83_RS04595	COG0802	atpase or kinase
AXH83_RS04600	COG0109	protoheme IX farnesyltransferase activity
AXH83_RS04610	COG1213	nucleotidyl transferase
AXH83_RS04610	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
AXH83_RS04615	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
AXH83_RS04630	COG1968	undecaprenyl-diphosphatase activity
AXH83_RS04650	COG0793	Belongs to the peptidase S41A family
AXH83_RS04655	COG0077	Prephenate dehydratase
AXH83_RS04655	COG1605	Chorismate mutase
AXH83_RS04660	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AXH83_RS04665	COG0149	triose-phosphate isomerase activity
AXH83_RS04670	COG0126	phosphoglycerate kinase activity
AXH83_RS04680	COG0124	histidyl-tRNA synthetase
AXH83_RS04685	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
AXH83_RS04695	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AXH83_RS04710	COG3437	response regulator, receiver
AXH83_RS04710	COG0784	Response regulator, receiver
AXH83_RS04725	COG1193	negative regulation of DNA recombination
AXH83_RS04730	COG1610	YqeY-like protein
AXH83_RS04740	COG0138	bifunctional purine biosynthesis protein purh
AXH83_RS04750	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
AXH83_RS04755	COG0517	IMP dehydrogenase activity
AXH83_RS04755	COG0516	GMP reductase activity
AXH83_RS04760	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
AXH83_RS04765	COG0482	sulfurtransferase activity
AXH83_RS04775	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AXH83_RS04780	COG0446	pyridine nucleotide-disulphide oxidoreductase
AXH83_RS04800	COG0444	Belongs to the ABC transporter superfamily
AXH83_RS04820	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
AXH83_RS04825	COG0322	excinuclease ABC activity
AXH83_RS04830	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
AXH83_RS04840	COG0820	rRNA (adenine-C2-)-methyltransferase activity
AXH83_RS04845	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
AXH83_RS04855	COG2204	response regulator
AXH83_RS04860	COG4191	Histidine kinase
AXH83_RS04865	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AXH83_RS04890	COG0307	riboflavin synthase, alpha
AXH83_RS04895	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
AXH83_RS04910	COG1792	Involved in formation and maintenance of cell shape
AXH83_RS04920	COG0463	Glycosyl transferase, family 2
AXH83_RS04930	COG0583	DNA-binding transcription factor activity
AXH83_RS04940	COG1921	L-seryl-tRNASec selenium transferase activity
AXH83_RS04950	COG1024	Enoyl-CoA hydratase
AXH83_RS04955	COG1250	3-hydroxyacyl-CoA dehydrogenase
AXH83_RS04960	COG3706	GGDEF domain
AXH83_RS04965	COG2203	Gaf domain
AXH83_RS04965	COG4251	negative regulation of phosphorylation
AXH83_RS04965	COG5001	Diguanylate cyclase
AXH83_RS04965	COG3706	GGDEF domain
AXH83_RS04975	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
AXH83_RS04980	COG3328	transposase activity
AXH83_RS05005	COG0792	nuclease activity
AXH83_RS05010	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
AXH83_RS05015	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
AXH83_RS05025	COG0210	DNA helicase
AXH83_RS05030	COG0038	chloride channel
AXH83_RS05035	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AXH83_RS05040	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
AXH83_RS05045	COG1024	Enoyl-CoA hydratase
AXH83_RS05050	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AXH83_RS05055	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
AXH83_RS05060	COG0009	L-threonylcarbamoyladenylate synthase
AXH83_RS05065	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
AXH83_RS05070	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
AXH83_RS05075	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
AXH83_RS05080	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
AXH83_RS05085	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
AXH83_RS05090	COG0165	Argininosuccinate lyase
AXH83_RS05090	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
AXH83_RS05095	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
AXH83_RS05105	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AXH83_RS05105	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
AXH83_RS05110	COG0237	dephospho-CoA kinase activity
AXH83_RS05120	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
AXH83_RS05125	COG0735	belongs to the Fur family
AXH83_RS05130	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
AXH83_RS05145	COG3328	transposase activity
AXH83_RS05160	COG2197	response regulator
AXH83_RS05190	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
AXH83_RS05195	COG1324	tolerance protein
AXH83_RS05200	COG0674	pyruvate-flavodoxin oxidoreductase activity
AXH83_RS05205	COG1013	pyruvate-flavodoxin oxidoreductase activity
AXH83_RS05210	COG2267	carboxylic ester hydrolase activity
AXH83_RS05225	COG0525	valine-tRNA ligase activity
AXH83_RS05230	COG1663	tetraacyldisaccharide 4'-kinase activity
AXH83_RS05235	COG0768	penicillin binding
AXH83_RS05240	COG0772	Belongs to the SEDS family
AXH83_RS05250	COG0758	DNA mediated transformation
AXH83_RS05250	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
AXH83_RS05255	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AXH83_RS05265	COG0497	DNA recombination
AXH83_RS05280	COG0751	glycine-tRNA ligase activity
AXH83_RS05305	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
AXH83_RS05305	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
AXH83_RS05310	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
AXH83_RS05315	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
AXH83_RS05320	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
AXH83_RS05325	COG1024	Enoyl-CoA hydratase
AXH83_RS05335	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
AXH83_RS05340	COG1518	maintenance of DNA repeat elements
AXH83_RS05385	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
AXH83_RS05395	COG0741	lytic transglycosylase activity
AXH83_RS05400	COG0552	protein localization to endoplasmic reticulum
AXH83_RS05410	COG0220	tRNA (guanine-N7-)-methyltransferase activity
AXH83_RS05425	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AXH83_RS05440	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
AXH83_RS05445	COG1181	Belongs to the D-alanine--D-alanine ligase family
AXH83_RS05455	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
AXH83_RS05460	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
AXH83_RS05465	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
AXH83_RS05470	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
AXH83_RS05485	COG0275	rRNA processing
AXH83_RS05510	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
AXH83_RS05515	COG0668	transmembrane transport
AXH83_RS05520	COG0183	Belongs to the thiolase family
AXH83_RS05530	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
AXH83_RS05540	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
AXH83_RS05545	COG0019	diaminopimelate decarboxylase activity
AXH83_RS05555	COG0165	Argininosuccinate lyase
AXH83_RS05565	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AXH83_RS05575	COG0674	pyruvate-flavodoxin oxidoreductase activity
AXH83_RS05580	COG1013	pyruvate-flavodoxin oxidoreductase activity
AXH83_RS05585	COG1716	ATPase activity
AXH83_RS05585	COG5001	Diguanylate cyclase
AXH83_RS05590	COG2050	protein possibly involved in aromatic compounds catabolism
AXH83_RS05605	COG1074	ATP-dependent DNA helicase activity
AXH83_RS05610	COG1830	Aldolase
AXH83_RS05615	COG1465	3-dehydroquinate synthase
AXH83_RS05625	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
AXH83_RS05630	COG2814	Major facilitator Superfamily
AXH83_RS05635	COG1566	PFAM secretion protein HlyD family protein
AXH83_RS05645	COG1309	transcriptional regulator
AXH83_RS05660	COG1309	transcriptional regulator
AXH83_RS05675	COG3328	transposase activity
AXH83_RS05680	COG0101	tRNA pseudouridine synthase activity
AXH83_RS05685	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AXH83_RS05690	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
AXH83_RS05695	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AXH83_RS05710	COG0778	Nitroreductase
AXH83_RS05725	COG1385	rRNA (uridine-N3-)-methyltransferase activity
AXH83_RS05730	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
AXH83_RS05735	COG0167	dihydroorotate dehydrogenase activity
AXH83_RS05750	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
AXH83_RS05760	COG2361	Protein of unknown function DUF86
AXH83_RS05775	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
AXH83_RS05775	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
AXH83_RS05795	COG0495	leucyl-tRNA aminoacylation
AXH83_RS05820	COG0840	transmembrane signaling receptor activity
AXH83_RS05825	COG5001	Diguanylate cyclase
AXH83_RS05825	COG3300	MHYT domain
AXH83_RS05835	COG1420	regulation of RNA biosynthetic process
AXH83_RS05840	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
AXH83_RS05845	COG0484	heat shock protein binding
AXH83_RS05860	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
AXH83_RS05910	COG1210	Utp--glucose-1-phosphate uridylyltransferase
AXH83_RS05940	COG1122	ATPase activity
AXH83_RS05955	COG0310	cobalt ion transport
AXH83_RS05960	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
AXH83_RS05965	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
AXH83_RS05970	COG5557	Pfam Polysulphide reductase, NrfD
AXH83_RS05975	COG0437	4 iron, 4 sulfur cluster binding
AXH83_RS05980	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
AXH83_RS05985	COG0805	protein transport
AXH83_RS05990	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
AXH83_RS05995	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
AXH83_RS06000	COG0375	protein maturation
AXH83_RS06010	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
AXH83_RS06020	COG0309	Hydrogenase expression formation protein (HypE)
AXH83_RS06050	COG3328	transposase activity
AXH83_RS06060	COG2361	Protein of unknown function DUF86
AXH83_RS06075	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
AXH83_RS06085	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
AXH83_RS06095	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AXH83_RS06100	COG0778	Nitroreductase
AXH83_RS06105	COG1396	sequence-specific DNA binding
AXH83_RS06105	COG1917	Cupin 2, conserved barrel domain protein
AXH83_RS06120	COG1773	rubredoxin
AXH83_RS06130	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
AXH83_RS06145	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
AXH83_RS06150	COG1490	D-aminoacyl-tRNA deacylase activity
AXH83_RS06155	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AXH83_RS06170	COG0840	transmembrane signaling receptor activity
AXH83_RS06190	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
AXH83_RS06195	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
AXH83_RS06200	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
AXH83_RS06205	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
AXH83_RS06215	COG0268	Binds directly to 16S ribosomal RNA
AXH83_RS06225	COG0459	protein refolding
AXH83_RS06230	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
AXH83_RS06255	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AXH83_RS06260	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AXH83_RS06275	COG1543	Belongs to the glycosyl hydrolase 57 family
AXH83_RS06290	COG1449	Belongs to the glycosyl hydrolase 57 family
AXH83_RS06300	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
AXH83_RS06305	COG1090	epimerase
AXH83_RS06335	COG3328	transposase activity
AXH83_RS06360	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AXH83_RS06365	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AXH83_RS06375	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
AXH83_RS06375	COG0517	IMP dehydrogenase activity
AXH83_RS06380	COG2877	3-deoxy-8-phosphooctulonate synthase activity
AXH83_RS06385	COG0504	CTP synthase activity
AXH83_RS06390	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
AXH83_RS06400	COG0708	Exodeoxyribonuclease III
AXH83_RS06405	COG0745	RESPONSE REGULATOR receiver
AXH83_RS06410	COG5002	protein histidine kinase activity
AXH83_RS06475	COG3706	GGDEF domain
AXH83_RS06480	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AXH83_RS06480	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AXH83_RS06485	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
AXH83_RS06490	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AXH83_RS06495	COG1160	GTP binding
AXH83_RS06500	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
AXH83_RS06510	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
AXH83_RS06515	COG0740	serine-type endopeptidase activity
AXH83_RS06525	COG2814	Major facilitator Superfamily
AXH83_RS06535	COG0842	Transport permease protein
AXH83_RS06535	COG1129	ABC transporter
AXH83_RS06540	COG1131	(ABC) transporter
AXH83_RS06545	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AXH83_RS06550	COG1566	PFAM secretion protein HlyD family protein
AXH83_RS06560	COG1309	transcriptional regulator
AXH83_RS06595	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AXH83_RS06600	COG0527	aspartate kinase activity
AXH83_RS06605	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
AXH83_RS06610	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
AXH83_RS06615	COG0492	ferredoxin-NADP+ reductase activity
AXH83_RS06625	COG0456	acetyltransferase
AXH83_RS06630	COG0156	8-amino-7-oxononanoate synthase activity
AXH83_RS06635	COG0012	GTP binding
AXH83_RS06640	COG1183	phosphatidylcholine synthase activity
AXH83_RS06645	COG0688	phosphatidylethanolamine metabolic process
AXH83_RS06650	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
AXH83_RS06655	COG0440	acetolactate synthase activity
AXH83_RS06660	COG0028	Belongs to the TPP enzyme family
AXH83_RS06665	COG0129	dihydroxy-acid dehydratase activity
AXH83_RS06680	COG1214	PFAM Peptidase M22, glycoprotease
AXH83_RS06695	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
AXH83_RS06700	COG0157	Belongs to the NadC ModD family
AXH83_RS06760	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
AXH83_RS06760	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
AXH83_RS06765	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
AXH83_RS06765	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
AXH83_RS06770	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
AXH83_RS06775	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
AXH83_RS06780	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
AXH83_RS06810	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
AXH83_RS06820	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
AXH83_RS06840	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
AXH83_RS06845	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
AXH83_RS06860	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
AXH83_RS06860	COG1796	DNA polymerase
AXH83_RS06900	COG0789	Transcriptional regulator
AXH83_RS06915	COG0489	protein tyrosine kinase activity
AXH83_RS06920	COG0489	protein tyrosine kinase activity
AXH83_RS06935	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
AXH83_RS06940	COG0571	ribonuclease III activity
AXH83_RS06945	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AXH83_RS06950	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AXH83_RS06955	COG1028	Short-chain dehydrogenase reductase Sdr
AXH83_RS06960	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
AXH83_RS06970	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
AXH83_RS06975	COG0416	fatty acid biosynthetic process
AXH83_RS06980	COG0333	Belongs to the bacterial ribosomal protein bL32 family
AXH83_RS07005	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
AXH83_RS07015	COG1469	GTP cyclohydrolase I activity
AXH83_RS07020	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
AXH83_RS07025	COG4608	Belongs to the ABC transporter superfamily
AXH83_RS07030	COG1804	L-carnitine dehydratase bile acid-inducible protein F
AXH83_RS07045	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
AXH83_RS07045	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
AXH83_RS07050	COG1515	deoxyribonuclease V activity
AXH83_RS07055	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
AXH83_RS07060	COG1100	Small GTP-binding protein
AXH83_RS07085	COG1028	Short-chain dehydrogenase reductase Sdr
AXH83_RS07090	COG2116	formate transmembrane transporter activity
AXH83_RS07095	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
AXH83_RS07100	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
AXH83_RS07105	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
AXH83_RS07110	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AXH83_RS07120	COG1519	Transferase
AXH83_RS07125	COG0346	lactoylglutathione lyase activity
AXH83_RS07140	COG0511	ligase activity, forming carbon-carbon bonds
AXH83_RS07140	COG5016	pyruvate
AXH83_RS07145	COG0439	Biotin carboxylase
AXH83_RS07150	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AXH83_RS07160	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
AXH83_RS07165	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
AXH83_RS07185	COG2885	chlorophyll binding
AXH83_RS07200	COG0438	transferase activity, transferring glycosyl groups
AXH83_RS07210	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
AXH83_RS07225	COG0577	efflux transmembrane transporter activity
AXH83_RS07225	COG1136	(ABC) transporter
AXH83_RS07230	COG0577	efflux transmembrane transporter activity
AXH83_RS07230	COG1136	(ABC) transporter
AXH83_RS07235	COG1136	(ABC) transporter
AXH83_RS07235	COG0577	efflux transmembrane transporter activity
AXH83_RS07240	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AXH83_RS07255	COG0137	argininosuccinate synthase activity
AXH83_RS07305	COG0166	Belongs to the GPI family
AXH83_RS07310	COG0556	nucleotide-excision repair
AXH83_RS07355	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
AXH83_RS07365	COG1702	phosphate starvation-inducible protein PhoH
AXH83_RS07370	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
AXH83_RS07375	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
AXH83_RS07380	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
AXH83_RS07385	COG0203	ribosomal protein L17
AXH83_RS07390	COG0202	RNA polymerase activity
AXH83_RS07395	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
AXH83_RS07400	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
AXH83_RS07410	COG0257	Belongs to the bacterial ribosomal protein bL36 family
AXH83_RS07415	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
AXH83_RS07420	COG0024	Methionine aminopeptidase
AXH83_RS07425	COG0563	adenylate kinase activity
AXH83_RS07430	COG0201	protein transport
AXH83_RS07435	COG0200	Binds to the 23S rRNA
AXH83_RS07440	COG1841	ribosomal large subunit assembly
AXH83_RS07445	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
AXH83_RS07450	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
AXH83_RS07455	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
AXH83_RS07460	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
AXH83_RS07465	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
AXH83_RS07470	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
AXH83_RS07475	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
AXH83_RS07480	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
AXH83_RS07485	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
AXH83_RS07490	COG0255	Belongs to the universal ribosomal protein uL29 family
AXH83_RS07495	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
AXH83_RS07500	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
AXH83_RS07505	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
AXH83_RS07510	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
AXH83_RS07515	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
AXH83_RS07520	COG0089	rRNA binding
AXH83_RS07530	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
AXH83_RS07535	COG0051	transcription antitermination factor activity, RNA binding
AXH83_RS07540	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AXH83_RS07545	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
AXH83_RS07550	COG0049	tRNA binding
AXH83_RS07555	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
AXH83_RS07560	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
AXH83_RS07565	COG0085	RNA polymerase activity
AXH83_RS07570	COG0222	ribosome binding
AXH83_RS07580	COG0081	regulation of translation
AXH83_RS07590	COG0250	Participates in transcription elongation, termination and antitermination
AXH83_RS07605	COG0267	Belongs to the bacterial ribosomal protein bL33 family
AXH83_RS07610	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AXH83_RS07645	COG0584	glycerophosphoryl diester phosphodiesterase
AXH83_RS07650	COG0535	radical SAM domain protein
AXH83_RS07655	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
AXH83_RS07660	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
AXH83_RS07660	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AXH83_RS07670	COG0011	TIGRFAM Protein of
AXH83_RS07675	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
AXH83_RS07685	COG1918	ferrous iron import across plasma membrane
AXH83_RS07685	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
AXH83_RS07705	COG0513	Belongs to the DEAD box helicase family
AXH83_RS07730	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AXH83_RS07735	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
AXH83_RS07745	COG2089	acid synthase
AXH83_RS07750	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
AXH83_RS07755	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
AXH83_RS07765	COG0277	FAD linked oxidase domain protein
AXH83_RS07790	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
AXH83_RS07795	COG0575	Belongs to the CDS family
AXH83_RS07800	COG0473	3-isopropylmalate dehydrogenase activity
AXH83_RS07805	COG0066	3-isopropylmalate dehydratase activity
AXH83_RS07810	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
AXH83_RS07815	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
AXH83_RS07825	COG0159	tryptophan synthase activity
AXH83_RS07830	COG0133	tryptophan synthase activity
AXH83_RS07835	COG0135	phosphoribosylanthranilate isomerase activity
AXH83_RS07840	COG0134	indole-3-glycerol-phosphate synthase activity
AXH83_RS07845	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AXH83_RS07915	COG1007	ATP synthesis coupled electron transport
AXH83_RS07925	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AXH83_RS07930	COG0713	ATP synthesis coupled electron transport
AXH83_RS07935	COG0839	Belongs to the complex I subunit 6 family
AXH83_RS07940	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AXH83_RS07945	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
AXH83_RS07955	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AXH83_RS07960	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AXH83_RS07965	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AXH83_RS07975	COG1611	Belongs to the LOG family
AXH83_RS07985	COG0730	response to heat
AXH83_RS08030	COG0840	transmembrane signaling receptor activity
AXH83_RS08035	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
AXH83_RS08040	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
AXH83_RS08040	COG1648	precorrin-2 dehydrogenase activity
AXH83_RS08050	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
AXH83_RS08055	COG1030	water channel activity
AXH83_RS08070	COG0616	signal peptide processing
AXH83_RS08075	COG0539	negative regulation of cytoplasmic translation
AXH83_RS08080	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
AXH83_RS08085	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AXH83_RS08100	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
AXH83_RS08110	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
AXH83_RS08120	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AXH83_RS08125	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
AXH83_RS08155	COG1492	cobalamin metabolic process
AXH83_RS08160	COG1584	GPR1 FUN34 yaaH family protein
AXH83_RS08180	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AXH83_RS08180	COG1042	CoA-binding domain protein
AXH83_RS08180	COG0045	succinate-CoA ligase (ADP-forming) activity
AXH83_RS08185	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
AXH83_RS08185	COG0574	Belongs to the PEP-utilizing enzyme family
AXH83_RS08200	COG0542	response to heat
AXH83_RS08205	COG0297	glycogen (starch) synthase activity
AXH83_RS08210	COG0058	SHG alpha-glucan phosphorylase activity
AXH83_RS08235	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AXH83_RS08255	COG1509	lysine 2,3-aminomutase activity
AXH83_RS08275	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
AXH83_RS08280	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
AXH83_RS08285	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
AXH83_RS08295	COG1618	nucleotide phosphatase activity, acting on free nucleotides
AXH83_RS08305	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AXH83_RS08325	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
AXH83_RS08330	COG1024	Enoyl-CoA hydratase
AXH83_RS08335	COG0511	ligase activity, forming carbon-carbon bonds
AXH83_RS08340	COG0439	Biotin carboxylase
AXH83_RS08355	COG5001	Diguanylate cyclase
AXH83_RS08355	COG3300	MHYT domain
AXH83_RS08365	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AXH83_RS08390	COG2119	membrane
AXH83_RS08420	COG1959	2 iron, 2 sulfur cluster binding
AXH83_RS08440	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
AXH83_RS08445	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
AXH83_RS08455	COG0037	tRNA processing
AXH83_RS08490	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AXH83_RS08495	COG0798	PFAM Bile acid sodium symporter
AXH83_RS08510	COG2084	Dehydrogenase
AXH83_RS08525	COG0193	aminoacyl-tRNA hydrolase activity
AXH83_RS08530	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
AXH83_RS08535	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
AXH83_RS08540	COG0828	Belongs to the bacterial ribosomal protein bS21 family
AXH83_RS08570	COG0347	Belongs to the P(II) protein family
AXH83_RS08585	COG1459	type II secretion system
AXH83_RS08600	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AXH83_RS08615	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
AXH83_RS08625	COG0052	Belongs to the universal ribosomal protein uS2 family
AXH83_RS08630	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
AXH83_RS08635	COG0528	UMP kinase activity
AXH83_RS08640	COG0233	cytoplasmic translational termination
AXH83_RS08650	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
AXH83_RS08660	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
AXH83_RS08665	COG2835	tetraacyldisaccharide 4'-kinase activity
AXH83_RS08670	COG1652	LysM domain
AXH83_RS08670	COG2823	Periplasmic or secreted lipoprotein
AXH83_RS08680	COG0442	prolyl-tRNA aminoacylation
AXH83_RS08690	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
AXH83_RS08710	COG0559	Belongs to the binding-protein-dependent transport system permease family
AXH83_RS08720	COG0351	phosphomethylpyrimidine kinase
AXH83_RS08720	COG1992	Thiamine-phosphate synthase
AXH83_RS08740	COG1966	Carbon starvation protein
AXH83_RS08750	COG0859	PFAM glycosyl transferase family 9
AXH83_RS08755	COG0439	Biotin carboxylase
AXH83_RS08760	COG0511	ligase activity, forming carbon-carbon bonds
AXH83_RS08765	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
AXH83_RS08770	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
AXH83_RS08775	COG0629	single-stranded DNA binding
AXH83_RS08780	COG0360	Binds together with S18 to 16S ribosomal RNA
AXH83_RS08790	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
AXH83_RS08795	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AXH83_RS08805	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AXH83_RS08810	COG0542	response to heat
AXH83_RS08815	COG0402	S-adenosylhomocysteine deaminase activity
AXH83_RS08820	COG0612	Peptidase, M16
AXH83_RS08825	COG0612	Peptidase, M16
AXH83_RS08830	COG1187	pseudouridine synthase activity
AXH83_RS08835	COG0047	phosphoribosylformylglycinamidine synthase activity
AXH83_RS08855	COG0235	Class ii aldolase
AXH83_RS08880	COG0823	Involved in the tonB-independent uptake of proteins
AXH83_RS08910	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
AXH83_RS08920	COG0585	pseudouridine synthase activity
AXH83_RS08925	COG0815	Transfers the fatty acyl group on membrane lipoproteins
AXH83_RS08930	COG0107	imidazoleglycerol-phosphate synthase activity
AXH83_RS08935	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
AXH83_RS08950	COG2197	response regulator
AXH83_RS08960	COG2197	response regulator
AXH83_RS08970	COG0587	DNA-directed DNA polymerase activity
AXH83_RS08975	COG0825	malonyl-CoA metabolic process
AXH83_RS08980	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
AXH83_RS08985	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
AXH83_RS08995	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
AXH83_RS09000	COG0037	tRNA processing
AXH83_RS09010	COG0731	radical SAM domain protein
AXH83_RS09010	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
AXH83_RS09015	COG2070	2-Nitropropane dioxygenase
AXH83_RS09030	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
AXH83_RS09035	COG0131	Imidazoleglycerol-phosphate dehydratase
AXH83_RS09045	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
AXH83_RS09055	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
AXH83_RS09060	COG0142	geranyltranstransferase activity
AXH83_RS09070	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
AXH83_RS09070	COG0140	phosphoribosyl-ATP diphosphatase activity
AXH83_RS09075	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AXH83_RS09100	COG0305	Participates in initiation and elongation during chromosome replication
AXH83_RS09105	COG0359	binds to the 23S rRNA
AXH83_RS09110	COG0840	transmembrane signaling receptor activity
AXH83_RS09115	COG0347	Belongs to the P(II) protein family
AXH83_RS09125	COG1139	Iron-sulfur cluster binding protein
AXH83_RS09130	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
AXH83_RS09135	COG5001	Diguanylate cyclase
AXH83_RS09135	COG3300	MHYT domain
AXH83_RS09145	COG0284	orotidine-5'-phosphate decarboxylase activity
AXH83_RS09150	COG0646	methionine synthase
AXH83_RS09150	COG1410	methionine synthase
AXH83_RS09175	COG1058	Belongs to the CinA family
AXH83_RS09175	COG1546	Belongs to the CinA family
AXH83_RS09200	COG0018	arginyl-trna synthetase
AXH83_RS09220	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
AXH83_RS09225	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
AXH83_RS09230	COG2890	protein-(glutamine-N5) methyltransferase activity
AXH83_RS09235	COG0436	Aminotransferase
AXH83_RS09250	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
AXH83_RS09255	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
AXH83_RS09265	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AXH83_RS09280	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
AXH83_RS09285	COG2264	protein methyltransferase activity
AXH83_RS09290	COG0647	UMP catabolic process
AXH83_RS09300	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
AXH83_RS09305	COG0537	adenosine 5'-monophosphoramidase activity
AXH83_RS09320	COG1573	uracil-dna glycosylase
AXH83_RS09330	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AXH83_RS09330	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
AXH83_RS09335	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
AXH83_RS09345	COG0586	Pfam SNARE associated Golgi protein
AXH83_RS09350	COG0179	Fumarylacetoacetate (FAA) hydrolase
AXH83_RS09355	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AXH83_RS09360	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
AXH83_RS09365	COG0181	hydroxymethylbilane synthase activity
AXH83_RS09370	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
AXH83_RS09370	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
AXH83_RS09375	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
AXH83_RS09380	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
AXH83_RS09385	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase