locus-tag	class	description
G4V39_RS00040	COG4771	TonB-dependent receptor
G4V39_RS00065	COG5002	protein histidine kinase activity
G4V39_RS00065	COG2205	protein histidine kinase activity
G4V39_RS00065	COG0784	Response regulator, receiver
G4V39_RS00070	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
G4V39_RS00080	COG4585	Histidine kinase
G4V39_RS00085	COG2197	response regulator
G4V39_RS00115	COG0457	Tetratricopeptide repeat
G4V39_RS00115	COG0463	Glycosyl transferase, family 2
G4V39_RS00130	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
G4V39_RS00135	COG0367	asparagine synthase
G4V39_RS00150	COG4106	trans-aconitate 2-methyltransferase activity
G4V39_RS00165	COG4656	Part of a membrane complex involved in electron transport
G4V39_RS00170	COG4658	electron transport chain
G4V39_RS00180	COG4660	Part of a membrane complex involved in electron transport
G4V39_RS00185	COG4657	Part of a membrane complex involved in electron transport
G4V39_RS00195	COG1148	4fe-4S ferredoxin, iron-sulfur binding domain protein
G4V39_RS00195	COG2878	Part of a membrane complex involved in electron transport
G4V39_RS00205	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
G4V39_RS00210	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
G4V39_RS00215	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
G4V39_RS00220	COG0649	NAD binding
G4V39_RS00225	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
G4V39_RS00230	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
G4V39_RS00235	COG0839	Belongs to the complex I subunit 6 family
G4V39_RS00255	COG1007	ATP synthesis coupled electron transport
G4V39_RS00285	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
G4V39_RS00290	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
G4V39_RS00295	COG2835	tetraacyldisaccharide 4'-kinase activity
G4V39_RS00300	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
G4V39_RS00310	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
G4V39_RS00320	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
G4V39_RS00325	COG0552	protein localization to endoplasmic reticulum
G4V39_RS00330	COG0563	adenylate kinase activity
G4V39_RS00345	COG0569	domain protein
G4V39_RS00350	COG0297	glycogen (starch) synthase activity
G4V39_RS00355	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
G4V39_RS00360	COG1832	CoA-binding protein
G4V39_RS00375	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
G4V39_RS00380	COG0217	transcriptional regulatory protein
G4V39_RS00385	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
G4V39_RS00395	COG2255	four-way junction helicase activity
G4V39_RS00400	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
G4V39_RS00415	COG0617	tRNA 3'-terminal CCA addition
G4V39_RS00440	COG4771	TonB-dependent receptor
G4V39_RS00445	COG0006	proline dipeptidase activity
G4V39_RS00455	COG1110	DNA topoisomerase II activity
G4V39_RS00460	COG0424	maF-like protein
G4V39_RS00465	COG0084	hydrolase, TatD family'
G4V39_RS00485	COG0589	response to stress
G4V39_RS00490	COG1394	ATPase activity, coupled to movement of substances
G4V39_RS00495	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
G4V39_RS00500	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
G4V39_RS00520	COG1269	ATP hydrolysis coupled proton transport
G4V39_RS00535	COG4191	Histidine kinase
G4V39_RS00555	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
G4V39_RS00560	COG0731	radical SAM domain protein
G4V39_RS00560	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
G4V39_RS00570	COG1530	ribonuclease E activity
G4V39_RS00580	COG1381	Involved in DNA repair and RecF pathway recombination
G4V39_RS00585	COG1426	Protein conserved in bacteria
G4V39_RS00590	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
G4V39_RS00600	COG3956	TIGRFAM MazG family protein
G4V39_RS00605	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
G4V39_RS00615	COG1329	Transcriptional regulator
G4V39_RS00620	COG4956	integral membrane protein (PIN domain superfamily)
G4V39_RS00625	COG0564	pseudouridine synthase activity
G4V39_RS00630	COG0237	dephospho-CoA kinase activity
G4V39_RS00640	COG1691	(AIR) carboxylase
G4V39_RS00660	COG1047	Peptidyl-prolyl cis-trans
G4V39_RS00665	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
G4V39_RS00670	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
G4V39_RS00670	COG0758	DNA mediated transformation
G4V39_RS00675	COG0322	excinuclease ABC activity
G4V39_RS00685	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
G4V39_RS00685	COG2199	diguanylate cyclase activity
G4V39_RS00690	COG2204	response regulator
G4V39_RS00700	COG3620	sequence-specific DNA binding
G4V39_RS00700	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
G4V39_RS00700	COG0617	tRNA 3'-terminal CCA addition
G4V39_RS00715	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
G4V39_RS00730	COG0489	protein tyrosine kinase activity
G4V39_RS00735	COG2894	cell division
G4V39_RS00740	COG0489	protein tyrosine kinase activity
G4V39_RS00770	COG2105	PFAM AIG2 family protein
G4V39_RS00800	COG5001	Diguanylate cyclase
G4V39_RS00800	COG3300	MHYT domain
G4V39_RS00805	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
G4V39_RS00810	COG1151	hydroxylamine reductase activity
G4V39_RS00820	COG5000	phosphorelay sensor kinase activity
G4V39_RS00820	COG3279	Response regulator of the LytR AlgR family
G4V39_RS00840	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
G4V39_RS00850	COG0733	neurotransmitter:sodium symporter activity
G4V39_RS00860	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
G4V39_RS00865	COG0492	ferredoxin-NADP+ reductase activity
G4V39_RS00870	COG0501	Belongs to the peptidase M48B family
G4V39_RS00890	COG0432	Pfam Uncharacterised protein family UPF0047
G4V39_RS00915	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
G4V39_RS00945	COG0512	Glutamine amidotransferase of anthranilate synthase
G4V39_RS00945	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
G4V39_RS00950	COG1566	PFAM secretion protein HlyD family protein
G4V39_RS00955	COG2814	Major facilitator Superfamily
G4V39_RS00960	COG0840	transmembrane signaling receptor activity
G4V39_RS00965	COG4251	negative regulation of phosphorylation
G4V39_RS00970	COG0784	Response regulator, receiver
G4V39_RS00990	COG2095	MarC family integral membrane protein
G4V39_RS01005	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
G4V39_RS01010	COG0439	Biotin carboxylase
G4V39_RS01025	COG0010	Belongs to the arginase family
G4V39_RS01030	COG1121	(ABC) transporter
G4V39_RS01035	COG1108	ABC-type Mn2 Zn2 transport systems permease components
G4V39_RS01040	COG0589	response to stress
G4V39_RS01050	COG3264	Mechanosensitive ion channel
G4V39_RS01050	COG1196	nuclear chromosome segregation
G4V39_RS01055	COG0268	Binds directly to 16S ribosomal RNA
G4V39_RS01065	COG0495	leucyl-tRNA aminoacylation
G4V39_RS01070	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
G4V39_RS01075	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
G4V39_RS01080	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
G4V39_RS01080	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
G4V39_RS01085	COG0307	riboflavin synthase, alpha
G4V39_RS01090	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
G4V39_RS01090	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
G4V39_RS01105	COG2715	membrane protein required for spore maturation
G4V39_RS01110	COG1418	mRNA catabolic process
G4V39_RS01115	COG1242	4 iron, 4 sulfur cluster binding
G4V39_RS01120	COG0617	tRNA 3'-terminal CCA addition
G4V39_RS01145	COG4191	Histidine kinase
G4V39_RS01150	COG2204	response regulator
G4V39_RS01155	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
G4V39_RS01170	COG1605	Chorismate mutase
G4V39_RS01170	COG0077	Prephenate dehydratase
G4V39_RS01180	COG1216	Glycosyl transferase, family 2
G4V39_RS01200	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
G4V39_RS01215	COG0598	Magnesium transport protein CorA
G4V39_RS01225	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
G4V39_RS01230	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
G4V39_RS01245	COG0028	Belongs to the TPP enzyme family
G4V39_RS01250	COG0440	acetolactate synthase activity
G4V39_RS01255	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
G4V39_RS01260	COG0688	phosphatidylethanolamine metabolic process
G4V39_RS01265	COG1183	phosphatidylcholine synthase activity
G4V39_RS01270	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
G4V39_RS01275	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
G4V39_RS01280	COG0066	3-isopropylmalate dehydratase activity
G4V39_RS01310	COG0411	ABC transporter
G4V39_RS01320	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
G4V39_RS01340	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
G4V39_RS01350	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
G4V39_RS01375	COG2217	Heavy metal translocating P-type atpase
G4V39_RS01380	COG1067	ATP-dependent peptidase activity
G4V39_RS01395	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
G4V39_RS01480	COG1489	DNA binding
G4V39_RS01495	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
G4V39_RS01500	COG1305	Transglutaminase-like
G4V39_RS01505	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
G4V39_RS01510	COG4771	TonB-dependent receptor
G4V39_RS01530	COG1959	2 iron, 2 sulfur cluster binding
G4V39_RS01535	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
G4V39_RS01550	COG0232	Belongs to the dGTPase family. Type 2 subfamily
G4V39_RS01570	COG0745	RESPONSE REGULATOR receiver
G4V39_RS01580	COG0489	protein tyrosine kinase activity
G4V39_RS01590	COG0492	ferredoxin-NADP+ reductase activity
G4V39_RS01595	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
G4V39_RS01625	COG1458	PINc domain ribonuclease
G4V39_RS01630	COG1635	Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur
G4V39_RS01635	COG3383	formate dehydrogenase (NAD+) activity
G4V39_RS01645	COG1410	methionine synthase
G4V39_RS01645	COG0646	methionine synthase
G4V39_RS01690	COG1151	hydroxylamine reductase activity
G4V39_RS01695	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
G4V39_RS01700	COG2759	Belongs to the formate--tetrahydrofolate ligase family
G4V39_RS01750	COG0484	heat shock protein binding
G4V39_RS01760	COG0778	Nitroreductase
G4V39_RS01760	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
G4V39_RS01770	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
G4V39_RS01775	COG0573	inorganic phosphate transmembrane transporter activity
G4V39_RS01780	COG0581	inorganic phosphate transmembrane transporter activity
G4V39_RS01785	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
G4V39_RS01790	COG0704	Plays a role in the regulation of phosphate uptake
G4V39_RS01820	COG0390	transport system, permease component
G4V39_RS01825	COG3842	ATPase activity
G4V39_RS01830	COG0459	protein refolding
G4V39_RS01835	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
G4V39_RS01845	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
G4V39_RS01850	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
G4V39_RS01855	COG0436	Aminotransferase
G4V39_RS01860	COG0101	tRNA pseudouridine synthase activity
G4V39_RS01870	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
G4V39_RS01875	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
G4V39_RS01880	COG0303	'Molybdopterin
G4V39_RS01885	COG2414	aldehyde ferredoxin oxidoreductase
G4V39_RS01900	COG1910	domain protein
G4V39_RS01905	COG0148	phosphopyruvate hydratase activity
G4V39_RS01910	COG0776	regulation of translation
G4V39_RS01920	COG0784	Response regulator, receiver
G4V39_RS01920	COG2205	protein histidine kinase activity
G4V39_RS01920	COG5002	protein histidine kinase activity
G4V39_RS01925	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
G4V39_RS01930	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
G4V39_RS01935	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
G4V39_RS01940	COG0710	3-dehydroquinate dehydratase activity
G4V39_RS01955	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
G4V39_RS01990	COG0243	molybdopterin cofactor binding
G4V39_RS01995	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
G4V39_RS02000	COG2204	response regulator
G4V39_RS02010	COG3852	Histidine kinase
G4V39_RS02015	COG2204	response regulator
G4V39_RS02020	COG3852	Histidine kinase
G4V39_RS02030	COG1132	(ABC) transporter
G4V39_RS02065	COG1773	rubredoxin
G4V39_RS02070	COG0438	transferase activity, transferring glycosyl groups
G4V39_RS02075	COG0367	asparagine synthase
G4V39_RS02080	COG2045	Belongs to the ComB family
G4V39_RS02095	COG4822	anaerobic cobalamin biosynthetic process
G4V39_RS02105	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
G4V39_RS02110	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
G4V39_RS02130	COG0589	response to stress
G4V39_RS02145	COG2855	membrane
G4V39_RS02170	COG3706	GGDEF domain
G4V39_RS02175	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
G4V39_RS02175	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
G4V39_RS02180	COG1040	competence protein
G4V39_RS02185	COG0538	isocitrate dehydrogenase activity
G4V39_RS02195	COG0343	queuine tRNA-ribosyltransferase activity
G4V39_RS02215	COG1131	(ABC) transporter
G4V39_RS02220	COG1490	D-aminoacyl-tRNA deacylase activity
G4V39_RS02225	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
G4V39_RS02235	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
G4V39_RS02240	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
G4V39_RS02285	COG1201	RNA secondary structure unwinding
G4V39_RS02360	COG1061	Type III restriction enzyme res subunit
G4V39_RS02395	COG4974	Belongs to the 'phage' integrase family
G4V39_RS02405	COG4274	PFAM GYD family protein
G4V39_RS02425	COG0426	domain, Protein
G4V39_RS02430	COG1773	rubredoxin
G4V39_RS02440	COG2033	superoxide reductase activity
G4V39_RS02455	COG0450	alkyl hydroperoxide reductase
G4V39_RS02460	COG1592	Rubrerythrin
G4V39_RS02475	COG0310	cobalt ion transport
G4V39_RS02480	COG0310	cobalt ion transport
G4V39_RS02490	COG1122	ATPase activity
G4V39_RS02500	COG1187	pseudouridine synthase activity
G4V39_RS02520	COG1335	isochorismatase
G4V39_RS02525	COG2176	DNA-directed DNA polymerase activity
G4V39_RS02540	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
G4V39_RS02550	COG0047	phosphoribosylformylglycinamidine synthase activity
G4V39_RS02555	COG0805	protein transport
G4V39_RS02565	COG1793	dna ligase
G4V39_RS02575	COG1796	DNA polymerase
G4V39_RS02575	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
G4V39_RS02585	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
G4V39_RS02610	COG0204	Acyl-transferase
G4V39_RS02615	COG0470	DNA polymerase III
G4V39_RS02620	COG1774	PSP1 C-terminal conserved region
G4V39_RS02625	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
G4V39_RS02625	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
G4V39_RS02630	COG1994	Peptidase M50
G4V39_RS02635	COG0180	Tryptophanyl-tRNA synthetase
G4V39_RS02650	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
G4V39_RS02670	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
G4V39_RS02685	COG0535	radical SAM domain protein
G4V39_RS02685	COG1433	Dinitrogenase iron-molybdenum cofactor
G4V39_RS02690	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
G4V39_RS02695	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
G4V39_RS02715	COG0347	Belongs to the P(II) protein family
G4V39_RS02725	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
G4V39_RS02740	COG0004	ammonium transporteR
G4V39_RS02760	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
G4V39_RS02765	COG1858	cytochrome C peroxidase
G4V39_RS02775	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
G4V39_RS02780	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
G4V39_RS02785	COG0142	geranyltranstransferase activity
G4V39_RS02790	COG1722	exodeoxyribonuclease VII activity
G4V39_RS02795	COG0739	heme binding
G4V39_RS02800	COG1570	exodeoxyribonuclease VII activity
G4V39_RS02810	COG4191	Histidine kinase
G4V39_RS02825	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
G4V39_RS02825	COG1648	precorrin-2 dehydrogenase activity
G4V39_RS02840	COG1606	tRNA processing
G4V39_RS02850	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
G4V39_RS02855	COG0517	IMP dehydrogenase activity
G4V39_RS02860	COG2204	response regulator
G4V39_RS02865	COG4191	Histidine kinase
G4V39_RS02875	COG0505	Belongs to the CarA family
G4V39_RS02880	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
G4V39_RS02885	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
G4V39_RS02905	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
G4V39_RS02920	COG2046	Belongs to the sulfate adenylyltransferase family
G4V39_RS02920	COG0529	Catalyzes the synthesis of activated sulfate
G4V39_RS02935	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
G4V39_RS02945	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
G4V39_RS02950	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
G4V39_RS02955	COG0489	protein tyrosine kinase activity
G4V39_RS02960	COG3409	Peptidoglycan-binding domain 1 protein
G4V39_RS02960	COG3267	Type II secretory pathway component ExeA
G4V39_RS02985	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
G4V39_RS02990	COG1555	photosystem II stabilization
G4V39_RS03005	COG0203	ribosomal protein L17
G4V39_RS03010	COG0202	RNA polymerase activity
G4V39_RS03015	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
G4V39_RS03020	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
G4V39_RS03025	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
G4V39_RS03030	COG0257	Belongs to the bacterial ribosomal protein bL36 family
G4V39_RS03035	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
G4V39_RS03045	COG0563	adenylate kinase activity
G4V39_RS03050	COG0201	protein transport
G4V39_RS03060	COG1841	ribosomal large subunit assembly
G4V39_RS03065	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
G4V39_RS03070	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
G4V39_RS03075	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
G4V39_RS03080	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
G4V39_RS03090	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
G4V39_RS03095	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
G4V39_RS03100	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
G4V39_RS03105	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
G4V39_RS03110	COG0255	Belongs to the universal ribosomal protein uL29 family
G4V39_RS03115	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
G4V39_RS03120	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
G4V39_RS03125	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
G4V39_RS03130	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
G4V39_RS03135	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
G4V39_RS03140	COG0089	rRNA binding
G4V39_RS03145	COG0088	Forms part of the polypeptide exit tunnel
G4V39_RS03150	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
G4V39_RS03155	COG0051	transcription antitermination factor activity, RNA binding
G4V39_RS03160	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
G4V39_RS03165	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
G4V39_RS03170	COG0049	tRNA binding
G4V39_RS03175	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
G4V39_RS03180	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
G4V39_RS03185	COG0085	RNA polymerase activity
G4V39_RS03190	COG0222	ribosome binding
G4V39_RS03195	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
G4V39_RS03200	COG0081	regulation of translation
G4V39_RS03205	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
G4V39_RS03215	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
G4V39_RS03225	COG0267	Belongs to the bacterial ribosomal protein bL33 family
G4V39_RS03230	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
G4V39_RS03255	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
G4V39_RS03260	COG1233	COG1233 Phytoene dehydrogenase and related
G4V39_RS03275	COG2046	Belongs to the sulfate adenylyltransferase family
G4V39_RS03280	COG0746	molybdenum cofactor guanylyltransferase activity
G4V39_RS03310	COG2197	response regulator
G4V39_RS03345	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
G4V39_RS03350	COG2226	methyltransferase
G4V39_RS03355	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
G4V39_RS03360	COG0402	S-adenosylhomocysteine deaminase activity
G4V39_RS03365	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
G4V39_RS03370	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
G4V39_RS03380	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
G4V39_RS03390	COG0628	permease
G4V39_RS03395	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
G4V39_RS03425	COG0701	Predicted permease
G4V39_RS03440	COG0798	PFAM Bile acid sodium symporter
G4V39_RS03495	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
G4V39_RS03505	COG0419	ATPase involved in DNA repair
G4V39_RS03520	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
G4V39_RS03525	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
G4V39_RS03530	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
G4V39_RS03555	COG0745	RESPONSE REGULATOR receiver
G4V39_RS03560	COG5002	protein histidine kinase activity
G4V39_RS03575	COG1619	proteins homologs of microcin C7 resistance protein MccF
G4V39_RS03580	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
G4V39_RS03590	COG0606	chelatase, subunit chli
G4V39_RS03595	COG0431	NADPH-dependent FMN reductase
G4V39_RS03600	COG3852	Histidine kinase
G4V39_RS03610	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
G4V39_RS03620	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
G4V39_RS03635	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
G4V39_RS03655	COG3339	Conserved Protein
G4V39_RS03660	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
G4V39_RS03665	COG0442	prolyl-tRNA aminoacylation
G4V39_RS03675	COG0227	Belongs to the bacterial ribosomal protein bL28 family
G4V39_RS03690	COG0406	alpha-ribazole phosphatase activity
G4V39_RS03695	COG0501	Belongs to the peptidase M48B family
G4V39_RS03700	COG0519	Catalyzes the synthesis of GMP from XMP
G4V39_RS03705	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
G4V39_RS03715	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
G4V39_RS03720	COG0463	Glycosyl transferase, family 2
G4V39_RS03730	COG0671	phosphoesterase, PA-phosphatase related
G4V39_RS03735	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
G4V39_RS03740	COG2204	response regulator
G4V39_RS03745	COG2205	protein histidine kinase activity
G4V39_RS03755	COG0840	transmembrane signaling receptor activity
G4V39_RS03760	COG0123	including yeast histone deacetylase and acetoin utilization protein
G4V39_RS03775	COG0708	Exodeoxyribonuclease III
G4V39_RS03790	COG0469	pyruvate kinase activity
G4V39_RS03800	COG1032	radical SAM domain protein
G4V39_RS03820	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
G4V39_RS03825	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
G4V39_RS03830	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
G4V39_RS03840	COG0635	Involved in the biosynthesis of porphyrin-containing compound
G4V39_RS03850	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
G4V39_RS03855	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
G4V39_RS03895	COG0613	PHP domain protein
G4V39_RS03900	COG0589	response to stress
G4V39_RS03910	COG2082	Precorrin-8x methylmutase
G4V39_RS03920	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
G4V39_RS03935	COG4948	Mandelate Racemase Muconate Lactonizing
G4V39_RS03940	COG2067	long-chain fatty acid transport protein
G4V39_RS03945	COG2153	protein acetylation
G4V39_RS03955	COG0330	HflC and HflK could
G4V39_RS03965	COG1573	uracil-dna glycosylase
G4V39_RS03970	COG2204	response regulator
G4V39_RS03975	COG5002	protein histidine kinase activity
G4V39_RS03990	COG0662	Cupin 2, conserved barrel domain protein
G4V39_RS03990	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
G4V39_RS04010	COG1013	pyruvate-flavodoxin oxidoreductase activity
G4V39_RS04015	COG0674	pyruvate-flavodoxin oxidoreductase activity
G4V39_RS04015	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
G4V39_RS04025	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
G4V39_RS04050	COG0038	chloride channel
G4V39_RS04065	COG1047	Peptidyl-prolyl cis-trans
G4V39_RS04070	COG0719	Fe-S assembly protein
G4V39_RS04075	COG0396	ATPase activity
G4V39_RS04080	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
G4V39_RS04085	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
G4V39_RS04090	COG0805	protein transport
G4V39_RS04095	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
G4V39_RS04100	COG0512	Glutamine amidotransferase of anthranilate synthase
G4V39_RS04105	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
G4V39_RS04110	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
G4V39_RS04115	COG3118	belongs to the thioredoxin family
G4V39_RS04120	COG0492	ferredoxin-NADP+ reductase activity
G4V39_RS04130	COG0864	Transcriptional regulator
G4V39_RS04140	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
G4V39_RS04145	COG1450	Type ii and iii secretion system protein
G4V39_RS04175	COG0481	GTPase activity
G4V39_RS04190	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
G4V39_RS04200	COG1058	Belongs to the CinA family
G4V39_RS04200	COG1546	Belongs to the CinA family
G4V39_RS04210	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
G4V39_RS04215	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
G4V39_RS04220	COG1077	Cell shape determining protein MreB Mrl
G4V39_RS04225	COG0483	inositol monophosphate 1-phosphatase activity
G4V39_RS04230	COG0494	nUDIX hydrolase
G4V39_RS04235	COG3706	GGDEF domain
G4V39_RS04240	COG0557	exoribonuclease II activity
G4V39_RS04255	COG0131	Imidazoleglycerol-phosphate dehydratase
G4V39_RS04270	COG1309	transcriptional regulator
G4V39_RS04275	COG0151	Belongs to the GarS family
G4V39_RS04280	COG0009	L-threonylcarbamoyladenylate synthase
G4V39_RS04285	COG1328	CTP reductase activity
G4V39_RS04295	COG0316	Belongs to the HesB IscA family
G4V39_RS04295	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
G4V39_RS04300	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
G4V39_RS04305	COG1921	L-seryl-tRNASec selenium transferase activity
G4V39_RS04320	COG1234	tRNA 3'-trailer cleavage
G4V39_RS04325	COG0133	tryptophan synthase activity
G4V39_RS04330	COG0159	tryptophan synthase activity
G4V39_RS04335	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
G4V39_RS04340	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
G4V39_RS04350	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
G4V39_RS04355	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
G4V39_RS04360	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
G4V39_RS04370	COG1253	flavin adenine dinucleotide binding
G4V39_RS04375	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
G4V39_RS04380	COG0105	UTP biosynthetic process
G4V39_RS04385	COG0071	Belongs to the small heat shock protein (HSP20) family
G4V39_RS04395	COG0544	peptidyl-prolyl cis-trans isomerase activity
G4V39_RS04400	COG0740	serine-type endopeptidase activity
G4V39_RS04405	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
G4V39_RS04410	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
G4V39_RS04425	COG1434	Gram-negative-bacterium-type cell wall biogenesis
G4V39_RS04430	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
G4V39_RS04440	COG1674	ftsk spoiiie
G4V39_RS04450	COG1469	GTP cyclohydrolase I activity
G4V39_RS04455	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
G4V39_RS04460	COG0352	thiamine-phosphate diphosphorylase activity
G4V39_RS04460	COG0351	phosphomethylpyrimidine kinase
G4V39_RS04470	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
G4V39_RS04500	COG1598	PFAM Uncharacterised protein family UPF0150
G4V39_RS04525	COG1598	PFAM Uncharacterised protein family UPF0150
G4V39_RS04575	COG1278	Cold shock
G4V39_RS04585	COG0196	riboflavin kinase activity
G4V39_RS04590	COG0142	geranyltranstransferase activity
G4V39_RS04600	COG0612	Peptidase, M16
G4V39_RS04605	COG1185	polyribonucleotide nucleotidyltransferase activity
G4V39_RS04610	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
G4V39_RS04615	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
G4V39_RS04625	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
G4V39_RS04635	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
G4V39_RS04645	COG0195	Participates in both transcription termination and antitermination
G4V39_RS04650	COG0779	Required for maturation of 30S ribosomal subunits
G4V39_RS04660	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
G4V39_RS04675	COG1216	Glycosyl transferase, family 2
G4V39_RS04680	COG3621	Patatin-like phospholipase
G4V39_RS04685	COG0543	2 iron, 2 sulfur cluster binding
G4V39_RS04690	COG0167	dihydroorotate dehydrogenase activity
G4V39_RS04700	COG2333	competence protein COMEC
G4V39_RS04700	COG0658	competence protein
G4V39_RS04710	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
G4V39_RS04710	COG0662	Cupin 2, conserved barrel domain protein
G4V39_RS04715	COG0574	Belongs to the PEP-utilizing enzyme family
G4V39_RS04715	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
G4V39_RS04725	COG1530	ribonuclease E activity
G4V39_RS04735	COG0436	Aminotransferase
G4V39_RS04740	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
G4V39_RS04740	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
G4V39_RS04750	COG0741	lytic transglycosylase activity
G4V39_RS04760	COG1260	myo-inositol-1-phosphate synthase
G4V39_RS04770	COG0071	Belongs to the small heat shock protein (HSP20) family
G4V39_RS04795	COG0437	4 iron, 4 sulfur cluster binding
G4V39_RS04810	COG0725	ABC transporter, periplasmic molybdate-binding protein
G4V39_RS04815	COG1177	transmembrane transport
G4V39_RS04830	COG0540	Belongs to the ATCase OTCase family
G4V39_RS04835	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
G4V39_RS04840	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
G4V39_RS04845	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
G4V39_RS04850	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
G4V39_RS04870	COG0590	tRNA wobble adenosine to inosine editing
G4V39_RS04885	COG0288	reversible hydration of carbon dioxide
G4V39_RS04890	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
G4V39_RS04895	COG1022	Amp-dependent synthetase and ligase
G4V39_RS04900	COG1980	fructose-bisphosphate aldolase activity
G4V39_RS04905	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
G4V39_RS04910	COG1830	Aldolase
G4V39_RS04920	COG0443	Heat shock 70 kDa protein
G4V39_RS04935	COG1509	lysine 2,3-aminomutase activity
G4V39_RS04940	COG1605	Chorismate mutase
G4V39_RS04940	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
G4V39_RS04960	COG0693	protein deglycase activity
G4V39_RS04965	COG0166	Belongs to the GPI family
G4V39_RS04980	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
G4V39_RS04985	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
G4V39_RS04990	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
G4V39_RS05000	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
G4V39_RS05005	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
G4V39_RS05010	COG0019	diaminopimelate decarboxylase activity
G4V39_RS05020	COG0165	Argininosuccinate lyase
G4V39_RS05025	COG0134	indole-3-glycerol-phosphate synthase activity
G4V39_RS05040	COG0391	Required for morphogenesis under gluconeogenic growth conditions
G4V39_RS05055	COG3706	GGDEF domain
G4V39_RS05075	COG0409	Hydrogenase expression formation protein
G4V39_RS05080	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
G4V39_RS05090	COG0588	phosphoglycerate mutase activity
G4V39_RS05095	COG1966	Carbon starvation protein
G4V39_RS05100	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
G4V39_RS05125	COG1210	Utp--glucose-1-phosphate uridylyltransferase
G4V39_RS05130	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
G4V39_RS05140	COG1968	undecaprenyl-diphosphatase activity
G4V39_RS05145	COG0242	peptide deformylase activity
G4V39_RS05160	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
G4V39_RS05175	COG0298	carbon dioxide binding
G4V39_RS05180	COG0375	protein maturation
G4V39_RS05225	COG0742	ribosomal rna small subunit methyltransferase
G4V39_RS05230	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
G4V39_RS05235	COG0546	phosphoglycolate phosphatase activity
G4V39_RS05240	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
G4V39_RS05245	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
G4V39_RS05250	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
G4V39_RS05260	COG2003	Belongs to the UPF0758 family
G4V39_RS05265	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
G4V39_RS05280	COG1104	cysteine desulfurase activity
G4V39_RS05285	COG0822	iron-sulfur transferase activity
G4V39_RS05300	COG1032	radical SAM domain protein
G4V39_RS05310	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
G4V39_RS05325	COG4651	solute:proton antiporter activity
G4V39_RS05325	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
G4V39_RS05360	COG1254	Belongs to the acylphosphatase family
G4V39_RS05365	COG2195	Cleaves the N-terminal amino acid of tripeptides
G4V39_RS05370	COG4191	Histidine kinase
G4V39_RS05405	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
G4V39_RS05410	COG0149	triose-phosphate isomerase activity
G4V39_RS05415	COG0126	phosphoglycerate kinase activity
G4V39_RS05420	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
G4V39_RS05445	COG0784	Response regulator, receiver
G4V39_RS05445	COG2198	Histidine kinase
G4V39_RS05445	COG0643	Histidine kinase
G4V39_RS05455	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
G4V39_RS05465	COG4191	Histidine kinase
G4V39_RS05470	COG2201	protein-glutamate methylesterase activity
G4V39_RS05475	COG0835	chemotaxis
G4V39_RS05480	COG0840	transmembrane signaling receptor activity
G4V39_RS05490	COG1192	Involved in chromosome partitioning
G4V39_RS05500	COG0803	Belongs to the bacterial solute-binding protein 9 family
G4V39_RS05500	COG3443	Belongs to the bacterial solute-binding protein 9 family
G4V39_RS05515	COG0004	ammonium transporteR
G4V39_RS05540	COG1615	UPF0182 protein
G4V39_RS05545	COG0531	amino acid
G4V39_RS05605	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
G4V39_RS05610	COG1692	metallophosphoesterase
G4V39_RS05615	COG1418	mRNA catabolic process
G4V39_RS05635	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
G4V39_RS05640	COG0355	proton-transporting ATP synthase activity, rotational mechanism
G4V39_RS05645	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
G4V39_RS05650	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
G4V39_RS05655	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
G4V39_RS05660	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
G4V39_RS05665	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
G4V39_RS05675	COG0772	Belongs to the SEDS family
G4V39_RS05680	COG0768	penicillin binding
G4V39_RS05700	COG1355	regulation of microtubule-based process
G4V39_RS05705	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
G4V39_RS05720	COG0438	transferase activity, transferring glycosyl groups
G4V39_RS05725	COG0218	Necessary for normal cell division and for the maintenance of normal septation
G4V39_RS05735	COG1473	amidohydrolase
G4V39_RS05740	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
G4V39_RS05745	COG0405	Gamma-glutamyltransferase
G4V39_RS05750	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
G4V39_RS05755	COG1730	sister chromatid segregation
G4V39_RS05765	COG2078	PFAM AMMECR1 domain protein
G4V39_RS05775	COG0511	ligase activity, forming carbon-carbon bonds
G4V39_RS05780	COG0235	Class ii aldolase
G4V39_RS05795	COG1459	type II secretion system
G4V39_RS05820	COG2801	Transposase and inactivated derivatives
G4V39_RS05840	COG1045	serine acetyltransferase
G4V39_RS05850	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
G4V39_RS05855	COG2873	o-acetylhomoserine
G4V39_RS05860	COG1959	2 iron, 2 sulfur cluster binding
G4V39_RS05870	COG0835	chemotaxis
G4V39_RS05875	COG0784	Response regulator, receiver
G4V39_RS05875	COG2198	Histidine kinase
G4V39_RS05875	COG0643	Histidine kinase
G4V39_RS05880	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
G4V39_RS05885	COG2201	protein-glutamate methylesterase activity
G4V39_RS05890	COG0745	RESPONSE REGULATOR receiver
G4V39_RS05900	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
G4V39_RS05905	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
G4V39_RS05910	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
G4V39_RS05915	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
G4V39_RS05920	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
G4V39_RS05930	COG1042	CoA-binding domain protein
G4V39_RS05930	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
G4V39_RS05930	COG0045	succinate-CoA ligase (ADP-forming) activity
G4V39_RS05945	COG0436	Aminotransferase
G4V39_RS05955	COG2204	response regulator
G4V39_RS05960	COG5000	phosphorelay sensor kinase activity
G4V39_RS05975	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
G4V39_RS05985	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
G4V39_RS05990	COG0527	aspartate kinase activity
G4V39_RS05995	COG0484	heat shock protein binding
G4V39_RS06000	COG0494	nUDIX hydrolase
G4V39_RS06005	COG2119	membrane
G4V39_RS06015	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
G4V39_RS06030	COG0356	it plays a direct role in the translocation of protons across the membrane
G4V39_RS06035	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
G4V39_RS06040	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
G4V39_RS06045	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
G4V39_RS06050	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
G4V39_RS06060	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
G4V39_RS06065	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
G4V39_RS06070	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
G4V39_RS06080	COG0135	phosphoribosylanthranilate isomerase activity
G4V39_RS06090	COG1131	(ABC) transporter
G4V39_RS06095	COG2204	response regulator
G4V39_RS06125	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
G4V39_RS06135	COG0535	radical SAM domain protein
G4V39_RS06140	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
G4V39_RS06145	COG0473	3-isopropylmalate dehydrogenase activity
G4V39_RS06155	COG0840	transmembrane signaling receptor activity
G4V39_RS06160	COG0571	ribonuclease III activity
G4V39_RS06165	COG0840	transmembrane signaling receptor activity
G4V39_RS06170	COG0484	heat shock protein binding
G4V39_RS06185	COG0113	porphobilinogen synthase activity
G4V39_RS06205	COG0019	diaminopimelate decarboxylase activity
G4V39_RS06220	COG0129	dihydroxy-acid dehydratase activity
G4V39_RS06230	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
G4V39_RS06250	COG0791	NLP P60 protein
G4V39_RS06250	COG1388	LysM domain
G4V39_RS06255	COG1388	LysM domain
G4V39_RS06255	COG1376	ErfK ybiS ycfS ynhG family protein
G4V39_RS06270	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
G4V39_RS06280	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
G4V39_RS06300	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
G4V39_RS06310	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
G4V39_RS06320	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
G4V39_RS06330	COG0312	modulator of DNA gyrase
G4V39_RS06335	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
G4V39_RS06335	COG0165	Argininosuccinate lyase
G4V39_RS06345	COG0018	arginyl-trna synthetase
G4V39_RS06355	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
G4V39_RS06370	COG0181	hydroxymethylbilane synthase activity
G4V39_RS06380	COG1379	DNA repair
G4V39_RS06385	COG0668	transmembrane transport
G4V39_RS06390	COG0557	exoribonuclease II activity
G4V39_RS06395	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
G4V39_RS06405	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
G4V39_RS06410	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
G4V39_RS06420	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
G4V39_RS06430	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
G4V39_RS06460	COG1104	cysteine desulfurase activity
G4V39_RS06465	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
G4V39_RS06470	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
G4V39_RS06475	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
G4V39_RS06500	COG1475	DNA binding
G4V39_RS06525	COG1993	acr, cog1993
G4V39_RS06535	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
G4V39_RS06535	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
G4V39_RS06545	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
G4V39_RS06550	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
G4V39_RS06565	COG0232	Belongs to the dGTPase family. Type 2 subfamily
G4V39_RS06585	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
G4V39_RS06590	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
G4V39_RS06600	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
G4V39_RS06610	COG5002	protein histidine kinase activity
G4V39_RS06615	COG0622	Phosphoesterase
G4V39_RS06625	COG1074	ATP-dependent DNA helicase activity
G4V39_RS06640	COG0138	bifunctional purine biosynthesis protein purh
G4V39_RS06680	COG2861	carbohydrate metabolic process
G4V39_RS06685	COG0793	Belongs to the peptidase S41A family
G4V39_RS06700	COG2884	Cell division ATP-binding protein ftsE
G4V39_RS06705	COG4969	Belongs to the N-Me-Phe pilin family
G4V39_RS06715	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
G4V39_RS06730	COG1561	YicC-like family, N-terminal region
G4V39_RS06735	COG2052	Domain of unknown function (DUF370)
G4V39_RS06740	COG0194	GDP metabolic process
G4V39_RS06745	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
G4V39_RS06750	COG1519	Transferase
G4V39_RS06755	COG1449	Belongs to the glycosyl hydrolase 57 family
G4V39_RS06765	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
G4V39_RS06765	COG1213	nucleotidyl transferase
G4V39_RS06770	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
G4V39_RS06785	COG0328	RNA-DNA hybrid ribonuclease activity
G4V39_RS06795	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
G4V39_RS06810	COG0358	DNA primase activity
G4V39_RS06815	COG1193	negative regulation of DNA recombination
G4V39_RS06820	COG0828	Belongs to the bacterial ribosomal protein bS21 family
G4V39_RS06830	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
G4V39_RS06835	COG0460	homoserine dehydrogenase
G4V39_RS06840	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
G4V39_RS06850	COG2920	part of a sulfur-relay system
G4V39_RS06865	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
G4V39_RS06875	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
G4V39_RS06880	COG0137	argininosuccinate synthase activity
G4V39_RS06885	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
G4V39_RS06890	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
G4V39_RS06905	COG1011	Hydrolase
G4V39_RS06915	COG4106	trans-aconitate 2-methyltransferase activity
G4V39_RS06930	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
G4V39_RS06935	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
G4V39_RS06940	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
G4V39_RS06940	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
G4V39_RS06945	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
G4V39_RS06960	COG1360	Flagellar Motor Protein
G4V39_RS06965	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
G4V39_RS06970	COG0360	Binds together with S18 to 16S ribosomal RNA
G4V39_RS06975	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
G4V39_RS06980	COG0359	binds to the 23S rRNA
G4V39_RS06985	COG0305	Participates in initiation and elongation during chromosome replication
G4V39_RS06990	COG0820	rRNA (adenine-C2-)-methyltransferase activity
G4V39_RS07005	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
G4V39_RS07010	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
G4V39_RS07030	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
G4V39_RS07035	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
G4V39_RS07050	COG0837	glucose binding
G4V39_RS07060	COG2885	chlorophyll binding
G4V39_RS07065	COG4970	Tfp pilus assembly protein FimT
G4V39_RS07100	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
G4V39_RS07110	COG1331	Highly conserved protein containing a thioredoxin domain
G4V39_RS07120	COG0215	cysteine-tRNA ligase activity
G4V39_RS07125	COG0437	4 iron, 4 sulfur cluster binding
G4V39_RS07130	COG0243	molybdopterin cofactor binding
G4V39_RS07135	COG3381	protein complex oligomerization
G4V39_RS07145	COG0284	orotidine-5'-phosphate decarboxylase activity
G4V39_RS07155	COG0482	sulfurtransferase activity
G4V39_RS07160	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
G4V39_RS07180	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
G4V39_RS07185	COG1324	tolerance protein
G4V39_RS07190	COG0107	imidazoleglycerol-phosphate synthase activity
G4V39_RS07195	COG3876	Protein conserved in bacteria
G4V39_RS07205	COG1196	nuclear chromosome segregation
G4V39_RS07205	COG3264	Mechanosensitive ion channel
G4V39_RS07215	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
G4V39_RS07220	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
G4V39_RS07225	COG1160	GTP binding
G4V39_RS07240	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
G4V39_RS07245	COG0805	protein transport
G4V39_RS07250	COG1686	Belongs to the peptidase S11 family
G4V39_RS07255	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
G4V39_RS07270	COG2951	lytic endotransglycosylase activity
G4V39_RS07275	COG0739	heme binding
G4V39_RS07305	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
G4V39_RS07320	COG0556	nucleotide-excision repair
G4V39_RS07335	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
G4V39_RS07340	COG0601	transmembrane transport
G4V39_RS07350	COG0789	Transcriptional regulator
G4V39_RS07355	COG3005	denitrification pathway
G4V39_RS07390	COG1758	RNA polymerase activity
G4V39_RS07395	COG0484	heat shock protein binding
G4V39_RS07400	COG0315	cyclic pyranopterin monophosphate synthase activity
G4V39_RS07405	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
G4V39_RS07420	COG4191	Histidine kinase
G4V39_RS07425	COG0745	RESPONSE REGULATOR receiver
G4V39_RS07450	COG0402	S-adenosylhomocysteine deaminase activity
G4V39_RS07465	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
G4V39_RS07480	COG0516	GMP reductase activity
G4V39_RS07485	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
G4V39_RS07490	COG0438	transferase activity, transferring glycosyl groups
G4V39_RS07520	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
G4V39_RS07525	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
G4V39_RS07530	COG0037	tRNA processing
G4V39_RS07540	COG3118	belongs to the thioredoxin family
G4V39_RS07565	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
G4V39_RS07570	COG0642	Histidine kinase
G4V39_RS07595	COG1196	nuclear chromosome segregation
G4V39_RS07645	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
G4V39_RS07655	COG0815	Transfers the fatty acyl group on membrane lipoproteins
G4V39_RS07670	COG1797	cobyrinic acid a,c-diamide synthase activity
G4V39_RS07675	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
G4V39_RS07680	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
G4V39_RS07695	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
G4V39_RS07700	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
G4V39_RS07705	COG0124	histidyl-tRNA synthetase
G4V39_RS07715	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
G4V39_RS07725	COG1100	Small GTP-binding protein
G4V39_RS07735	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
G4V39_RS07745	COG2221	Nitrite and sulphite reductase 4Fe-4S
G4V39_RS07750	COG2221	Nitrite and sulphite reductase 4Fe-4S
G4V39_RS07785	COG1797	cobyrinic acid a,c-diamide synthase activity
G4V39_RS07810	COG0039	L-malate dehydrogenase activity
G4V39_RS07820	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
G4V39_RS07830	COG0357	Ribosomal RNA small subunit methyltransferase G
G4V39_RS07835	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
G4V39_RS07840	COG1847	R3H domain protein
G4V39_RS07845	COG0706	membrane insertase activity
G4V39_RS07850	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
G4V39_RS07855	COG0594	ribonuclease P activity
G4V39_RS07860	COG0230	Belongs to the bacterial ribosomal protein bL34 family
G4V39_RS07865	COG1399	metal-binding, possibly nucleic acid-binding protein
G4V39_RS07870	COG0333	Belongs to the bacterial ribosomal protein bL32 family
G4V39_RS07880	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
G4V39_RS07890	COG2086	electron transfer activity
G4V39_RS07900	COG1028	Short-chain dehydrogenase reductase Sdr
G4V39_RS07905	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
G4V39_RS07910	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
G4V39_RS07915	COG0698	ribose 5-phosphate isomerase
G4V39_RS07920	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
G4V39_RS07925	COG2131	deaminase
G4V39_RS07930	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
G4V39_RS07945	COG1918	ferrous iron import across plasma membrane
G4V39_RS07945	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
G4V39_RS07950	COG3659	wide pore channel activity
G4V39_RS07975	COG0437	4 iron, 4 sulfur cluster binding
G4V39_RS07995	COG3290	protein histidine kinase activity
G4V39_RS07995	COG3829	transcription factor binding
G4V39_RS08015	COG0789	Transcriptional regulator
G4V39_RS08025	COG1214	PFAM Peptidase M22, glycoprotease
G4V39_RS08030	COG0750	zinc metalloprotease
G4V39_RS08035	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
G4V39_RS08050	COG0233	cytoplasmic translational termination
G4V39_RS08055	COG0528	UMP kinase activity
G4V39_RS08060	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
G4V39_RS08065	COG0052	Belongs to the universal ribosomal protein uS2 family
G4V39_RS08070	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
G4V39_RS08090	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
G4V39_RS08095	COG0071	Belongs to the small heat shock protein (HSP20) family
G4V39_RS08100	COG0745	RESPONSE REGULATOR receiver
G4V39_RS08120	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
G4V39_RS08125	COG1872	DUF167
G4V39_RS08130	COG3599	regulation of cell shape
G4V39_RS08135	COG0762	integral membrane protein
G4V39_RS08140	COG1058	Belongs to the CinA family
G4V39_RS08140	COG1546	Belongs to the CinA family
G4V39_RS08150	COG0322	excinuclease ABC activity
G4V39_RS08175	COG2333	competence protein COMEC
G4V39_RS08175	COG0658	competence protein
G4V39_RS08195	COG0537	adenosine 5'-monophosphoramidase activity
G4V39_RS08200	COG0542	response to heat
G4V39_RS08235	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
G4V39_RS08245	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
G4V39_RS08260	COG1137	ATPase activity
G4V39_RS08275	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
G4V39_RS08280	COG1660	Displays ATPase and GTPase activities
G4V39_RS08290	COG0456	acetyltransferase
G4V39_RS08295	COG1196	nuclear chromosome segregation
G4V39_RS08325	COG0037	tRNA processing
G4V39_RS08335	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
G4V39_RS08340	COG1333	cytochrome c biogenesis protein
G4V39_RS08345	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
G4V39_RS08350	COG0799	negative regulation of ribosome biogenesis
G4V39_RS08355	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
G4V39_RS08360	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
G4V39_RS08375	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
G4V39_RS08385	COG0674	pyruvate-flavodoxin oxidoreductase activity
G4V39_RS08390	COG1013	pyruvate-flavodoxin oxidoreductase activity
G4V39_RS08400	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
G4V39_RS08405	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
G4V39_RS08440	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
G4V39_RS08445	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
G4V39_RS08465	COG0823	Involved in the tonB-independent uptake of proteins
G4V39_RS08480	COG0215	cysteine-tRNA ligase activity
G4V39_RS08490	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
G4V39_RS08500	COG0730	response to heat
G4V39_RS08515	COG3852	Histidine kinase
G4V39_RS08545	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
G4V39_RS08565	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
G4V39_RS08580	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
G4V39_RS08580	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
G4V39_RS08595	COG0420	3'-5' exonuclease activity
G4V39_RS08615	COG0730	response to heat
G4V39_RS08625	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
G4V39_RS08625	COG0574	Belongs to the PEP-utilizing enzyme family
G4V39_RS08640	COG4191	Histidine kinase
G4V39_RS08650	COG2264	protein methyltransferase activity
G4V39_RS08660	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
G4V39_RS08665	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
G4V39_RS08670	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
G4V39_RS08675	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
G4V39_RS08685	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
G4V39_RS08690	COG2197	response regulator
G4V39_RS08710	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
G4V39_RS08715	COG0569	domain protein
G4V39_RS08725	COG2089	acid synthase
G4V39_RS08735	COG1012	belongs to the aldehyde dehydrogenase family
G4V39_RS08740	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
G4V39_RS08745	COG1083	cytidylyl-transferase
G4V39_RS08770	COG1388	LysM domain
G4V39_RS08770	COG1134	teichoic acid transport
G4V39_RS08800	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
G4V39_RS08805	COG0438	transferase activity, transferring glycosyl groups
G4V39_RS08830	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
G4V39_RS08840	COG1136	(ABC) transporter
G4V39_RS08845	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
G4V39_RS08850	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
G4V39_RS08855	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
G4V39_RS08860	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
G4V39_RS08865	COG3494	Protein of unknown function (DUF1009)
G4V39_RS08870	COG0673	inositol 2-dehydrogenase activity
G4V39_RS08875	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
G4V39_RS08880	COG1519	Transferase
G4V39_RS08885	COG1663	tetraacyldisaccharide 4'-kinase activity
G4V39_RS08895	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
G4V39_RS08900	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
G4V39_RS08905	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
G4V39_RS08910	COG0193	aminoacyl-tRNA hydrolase activity
G4V39_RS08925	COG0243	molybdopterin cofactor binding
G4V39_RS08930	COG0437	4 iron, 4 sulfur cluster binding
G4V39_RS08935	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
G4V39_RS08940	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
G4V39_RS08945	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
G4V39_RS08950	COG0649	NAD binding
G4V39_RS08955	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
G4V39_RS08960	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
G4V39_RS08970	COG0713	ATP synthesis coupled electron transport
G4V39_RS09000	COG4191	Histidine kinase
G4V39_RS09005	COG0745	RESPONSE REGULATOR receiver
G4V39_RS09010	COG0367	asparagine synthase
G4V39_RS09020	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
G4V39_RS09025	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
G4V39_RS09050	COG0436	Aminotransferase
G4V39_RS09055	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
G4V39_RS09060	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
G4V39_RS09065	COG0629	single-stranded DNA binding
G4V39_RS09090	COG1420	regulation of RNA biosynthetic process
G4V39_RS09095	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
G4V39_RS09100	COG0443	Heat shock 70 kDa protein
G4V39_RS09105	COG0776	regulation of translation
G4V39_RS09110	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
G4V39_RS09120	COG0776	regulation of translation
G4V39_RS09125	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
G4V39_RS09125	COG0072	phenylalanine-tRNA ligase activity
G4V39_RS09130	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
G4V39_RS09135	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
G4V39_RS09140	COG0291	Belongs to the bacterial ribosomal protein bL35 family
G4V39_RS09145	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
G4V39_RS09150	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
G4V39_RS09160	COG0668	transmembrane transport
G4V39_RS09175	COG1301	dicarboxylic acid transport
G4V39_RS09185	COG4752	Belongs to the RNA methyltransferase TrmD family
G4V39_RS09190	COG0336	Belongs to the RNA methyltransferase TrmD family
G4V39_RS09195	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
G4V39_RS09200	COG1837	Belongs to the UPF0109 family
G4V39_RS09205	COG0228	four-way junction DNA binding
G4V39_RS09210	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
G4V39_RS09215	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
G4V39_RS09230	COG0792	nuclease activity
G4V39_RS09235	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
G4V39_RS09240	COG0335	large ribosomal subunit rRNA binding
G4V39_RS09245	COG1181	Belongs to the D-alanine--D-alanine ligase family
G4V39_RS09255	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
G4V39_RS09260	COG0277	FAD linked oxidase domain protein
G4V39_RS09270	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
G4V39_RS09280	COG3852	Histidine kinase
G4V39_RS09295	COG0612	Peptidase, M16
G4V39_RS09305	COG2391	methyltransferase activity
G4V39_RS09310	COG0425	Belongs to the sulfur carrier protein TusA family
G4V39_RS09340	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
G4V39_RS09345	COG2890	protein-(glutamine-N5) methyltransferase activity
G4V39_RS09350	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
G4V39_RS09355	COG0254	rRNA binding
G4V39_RS09360	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
G4V39_RS09370	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
G4V39_RS09375	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
G4V39_RS09385	COG0123	including yeast histone deacetylase and acetoin utilization protein
G4V39_RS09390	COG2095	MarC family integral membrane protein
G4V39_RS09395	COG1525	nuclease
G4V39_RS09400	COG1533	DNA photolyase activity
G4V39_RS09410	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
G4V39_RS09450	COG1295	ribonuclease BN
G4V39_RS09455	COG0037	tRNA processing
G4V39_RS09465	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
G4V39_RS09470	COG1639	'signal transduction protein
G4V39_RS09480	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
G4V39_RS09480	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
G4V39_RS09485	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
G4V39_RS09490	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
G4V39_RS09540	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
G4V39_RS09545	COG2001	Belongs to the MraZ family
G4V39_RS09550	COG0275	rRNA processing
G4V39_RS09560	COG0768	penicillin binding
G4V39_RS09565	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
G4V39_RS09570	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
G4V39_RS09575	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
G4V39_RS09580	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
G4V39_RS09585	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
G4V39_RS09590	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
G4V39_RS09595	COG0812	UDP-N-acetylmuramate dehydrogenase activity
G4V39_RS09610	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
G4V39_RS09640	COG0497	DNA recombination
G4V39_RS09650	COG0004	ammonium transporteR
G4V39_RS09665	COG0357	Ribosomal RNA small subunit methyltransferase G
G4V39_RS09670	COG0504	CTP synthase activity
G4V39_RS09680	COG1543	Belongs to the glycosyl hydrolase 57 family
G4V39_RS09685	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
G4V39_RS09695	COG4191	Histidine kinase
G4V39_RS09700	COG5002	protein histidine kinase activity
G4V39_RS09700	COG3850	Histidine kinase
G4V39_RS09710	COG4771	TonB-dependent receptor
G4V39_RS09720	COG0525	valine-tRNA ligase activity
G4V39_RS09725	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
G4V39_RS09730	COG0521	Mo-molybdopterin cofactor biosynthetic process
G4V39_RS09740	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
G4V39_RS09745	COG0261	This protein binds to 23S rRNA in the presence of protein L20
G4V39_RS09750	COG0211	Belongs to the bacterial ribosomal protein bL27 family
G4V39_RS09760	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
G4V39_RS09765	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
G4V39_RS09820	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
G4V39_RS09870	COG0585	pseudouridine synthase activity
G4V39_RS09900	COG2807	transmembrane transport
G4V39_RS09915	COG0842	Transport permease protein
G4V39_RS09920	COG0842	Transport permease protein
G4V39_RS09920	COG1129	ABC transporter
G4V39_RS09925	COG0842	Transport permease protein
G4V39_RS09925	COG1129	ABC transporter
G4V39_RS09940	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
G4V39_RS09945	COG0602	queuosine metabolic process
G4V39_RS09980	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
G4V39_RS10020	COG0438	transferase activity, transferring glycosyl groups
G4V39_RS10025	COG0367	asparagine synthase
G4V39_RS10030	COG0438	transferase activity, transferring glycosyl groups
G4V39_RS10035	COG0438	transferase activity, transferring glycosyl groups
G4V39_RS10040	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
G4V39_RS10075	COG0438	transferase activity, transferring glycosyl groups
G4V39_RS10140	COG0109	protoheme IX farnesyltransferase activity
G4V39_RS10145	COG0367	asparagine synthase
G4V39_RS10160	COG1362	aminopeptidase activity
G4V39_RS10180	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
G4V39_RS10205	COG2264	protein methyltransferase activity
G4V39_RS10215	COG0012	GTP binding
G4V39_RS10220	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
G4V39_RS10225	COG0736	holo-[acyl-carrier-protein] synthase activity
G4V39_RS10230	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
G4V39_RS10230	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
G4V39_RS10235	COG0802	atpase or kinase
G4V39_RS10260	COG2204	response regulator
G4V39_RS10270	COG2204	response regulator
G4V39_RS10285	COG1677	Flagellar hook-basal body complex protein FliE
G4V39_RS10290	COG1766	The M ring may be actively involved in energy transduction
G4V39_RS10295	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
G4V39_RS10305	COG1157	protein secretion by the type III secretion system
G4V39_RS10325	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
G4V39_RS10335	COG1749	Flagellar hook protein flgE
G4V39_RS10340	COG1580	Controls the rotational direction of flagella during chemotaxis
G4V39_RS10360	COG1338	Plays a role in the flagellum-specific transport system
G4V39_RS10365	COG1987	bacterial-type flagellum assembly
G4V39_RS10370	COG1684	flagellar biosynthetic protein fliR
G4V39_RS10375	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
G4V39_RS10380	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
G4V39_RS10395	COG1191	sigma factor activity
G4V39_RS10420	COG4786	Flagellar basal body rod
G4V39_RS10425	COG4786	Flagellar basal body rod
G4V39_RS10435	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
G4V39_RS10440	COG1706	bacterial-type flagellum-dependent cell motility
G4V39_RS10460	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
G4V39_RS10470	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
G4V39_RS10485	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
G4V39_RS10490	COG0564	pseudouridine synthase activity
G4V39_RS10500	COG0751	glycine-tRNA ligase activity
G4V39_RS10505	COG0752	glycyl-tRNA synthetase alpha subunit
G4V39_RS10525	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
G4V39_RS10535	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
G4V39_RS10560	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
G4V39_RS10565	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
G4V39_RS10575	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
G4V39_RS10585	COG3852	Histidine kinase
G4V39_RS10605	COG0848	biopolymer transport protein
G4V39_RS10620	COG0646	methionine synthase
G4V39_RS10620	COG1410	methionine synthase
G4V39_RS10640	COG2264	protein methyltransferase activity
G4V39_RS10655	COG0243	molybdopterin cofactor binding
G4V39_RS10675	COG0745	RESPONSE REGULATOR receiver
G4V39_RS10680	COG5002	protein histidine kinase activity
G4V39_RS10685	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
G4V39_RS10695	COG3848	Pyruvate phosphate dikinase
G4V39_RS10695	COG0574	Belongs to the PEP-utilizing enzyme family
G4V39_RS10710	COG4589	Belongs to the CDS family
G4V39_RS10725	COG0312	modulator of DNA gyrase
G4V39_RS10735	COG4608	Belongs to the ABC transporter superfamily
G4V39_RS10740	COG0430	RNA-3'-phosphate cyclase activity
G4V39_RS10835	COG0516	GMP reductase activity
G4V39_RS10835	COG0517	IMP dehydrogenase activity
G4V39_RS10840	COG0248	Ppx GppA phosphatase
G4V39_RS10845	COG0616	signal peptide processing
G4V39_RS10850	COG0539	negative regulation of cytoplasmic translation
G4V39_RS10855	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
G4V39_RS10860	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
G4V39_RS10865	COG1151	hydroxylamine reductase activity
G4V39_RS10880	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
G4V39_RS10890	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
G4V39_RS10895	COG1294	oxidase, subunit
G4V39_RS10900	COG1271	oxidase subunit
G4V39_RS10910	COG3706	GGDEF domain
G4V39_RS10950	COG0778	Nitroreductase
G4V39_RS10960	COG0859	PFAM glycosyl transferase family 9
G4V39_RS10965	COG0438	transferase activity, transferring glycosyl groups
G4V39_RS10970	COG0438	transferase activity, transferring glycosyl groups
G4V39_RS10980	COG0726	polysaccharide deacetylase
G4V39_RS10990	COG0348	domain, Protein
G4V39_RS11010	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
G4V39_RS11020	COG0067	glutamate synthase
G4V39_RS11040	COG0154	amidase activity
G4V39_RS11055	COG2199	diguanylate cyclase activity
G4V39_RS11055	COG2203	Gaf domain
G4V39_RS11060	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
G4V39_RS11075	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
G4V39_RS11075	COG0426	domain, Protein
G4V39_RS11100	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
G4V39_RS11105	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
G4V39_RS11105	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
G4V39_RS11110	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
G4V39_RS11120	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
G4V39_RS11130	COG0735	belongs to the Fur family
G4V39_RS11190	COG1122	ATPase activity