locus-tag	class	description
tll0002	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
tll0008	COG4956	integral membrane protein (PIN domain superfamily)
tll0013	COG1473	amidohydrolase
tll0014	COG2954	triphosphatase activity
tll0015	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
tll0016	COG2211	Major facilitator Superfamily
tll0019	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
tll0021	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
tll0032	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
tll0037	COG1702	phosphate starvation-inducible protein PhoH
tll0043	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
tll0044	COG0425	Belongs to the sulfur carrier protein TusA family
tll0044	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
tll0045	COG1007	ATP synthesis coupled electron transport
tll0046	COG1619	proteins homologs of microcin C7 resistance protein MccF
tll0048	COG0735	belongs to the Fur family
tll0049	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
tll0054	COG0194	GDP metabolic process
tll0060	COG0420	3'-5' exonuclease activity
tll0065	COG2022	thiamine diphosphate biosynthetic process
tll0072	COG0628	permease
tll0073	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
tll0076	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
tll0080	COG0343	queuine tRNA-ribosyltransferase activity
tll0113	COG4802	Ferredoxin thioredoxin reductase catalytic beta chain
tll0118	COG0484	heat shock protein binding
tll0119	COG1459	type II secretion system
tll0120	COG1459	type II secretion system
tll0122	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
tll0128	COG0419	ATPase involved in DNA repair
tll0130	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
tll0131	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
tll0133	COG0131	Imidazoleglycerol-phosphate dehydratase
tll0141	COG1672	PFAM Archaeal ATPase
tll0142	COG4243	Vitamin k epoxide reductase
tll0145	COG0038	chloride channel
tll0150	COG0644	oxidoreductase
tll0153	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
tll0162	COG3842	ATPase activity
tll0167	COG0261	This protein binds to 23S rRNA in the presence of protein L20
tll0169	COG1959	2 iron, 2 sulfur cluster binding
tll0173	COG2082	Precorrin-8x methylmutase
tll0175	COG0217	transcriptional regulatory protein
tll0178	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
tll0180	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
tll0181	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
tll0182	COG0484	heat shock protein binding
tll0183	COG0788	formyltetrahydrofolate deformylase activity
tll0184	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
tll0185	COG0459	protein refolding
tll0186	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
tll0187	COG0395	ABC-type sugar transport system, permease component
tll0188	COG0004	ammonium transporteR
tll0202	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
tll0203	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
tll0204	COG0508	dehydrogenase complex catalyzes the overall conversion of
tll0204	COG0022	dehydrogenase e1 component
tll0211	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
tll0212	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
tll0214	COG1132	(ABC) transporter
tll0216	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
tll0218	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
tll0220	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
tll0223	COG4178	(ABC) transporter
tll0231	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
tll0233	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
tll0233	COG0140	phosphoribosyl-ATP diphosphatase activity
tll0236	COG0367	asparagine synthase
tll0251	COG2247	cell wall binding repeat
tll0251	COG0860	N-Acetylmuramoyl-L-alanine amidase
tll0259	COG0233	cytoplasmic translational termination
tll0260	COG0528	UMP kinase activity
tll0266	COG0384	phenazine biosynthesis protein PhzF
tll0268	COG0861	Integral membrane protein TerC family
tll0277	COG0460	homoserine dehydrogenase
tll0280	COG0484	heat shock protein binding
tll0288	COG0446	pyridine nucleotide-disulphide oxidoreductase
tll0303	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
tll0307	COG0542	response to heat
tll0314	COG0457	Tetratricopeptide repeat
tll0314	COG0463	Glycosyl transferase, family 2
tll0316	COG0811	peptide transport
tll0321	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
tll0322	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
tll0327	COG0438	transferase activity, transferring glycosyl groups
tll0330	COG0832	Belongs to the urease beta subunit family
tll0331	COG0259	pyridoxamine-phosphate oxidase activity
tll0337	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
tll0340	COG0429	hydrolase of the alpha beta-hydrolase fold
tll0358	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
tll0365	COG5398	heme oxygenase
tll0366	COG0165	Argininosuccinate lyase
tll0369	COG0463	Glycosyl transferase, family 2
tll0369	COG0457	Tetratricopeptide repeat
tll0370	COG0812	UDP-N-acetylmuramate dehydrogenase activity
tll0371	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
tll0381	COG2385	sporulation resulting in formation of a cellular spore
tll0385	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
tll0391	COG2385	sporulation resulting in formation of a cellular spore
tll0395	COG0284	orotidine-5'-phosphate decarboxylase activity
tll0403	COG2045	Belongs to the ComB family
tll0415	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
tll0418	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
tll0418	COG0438	transferase activity, transferring glycosyl groups
tll0422	COG0113	porphobilinogen synthase activity
tll0424	COG0024	Methionine aminopeptidase
tll0425	COG0415	Belongs to the DNA photolyase family
tll0439	COG0159	tryptophan synthase activity
tll0443	COG4172	Belongs to the ABC transporter superfamily
tll0451	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
tll0452	COG2177	Part of the ABC transporter FtsEX involved in
tll0453	COG2884	Cell division ATP-binding protein ftsE
tll0460	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
tll0463	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
tll0464	COG0316	Belongs to the HesB IscA family
tll0465	COG1090	epimerase
tll0467	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
tll0476	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
tll0480	COG2205	protein histidine kinase activity
tll0488	COG0824	Thioesterase
tll0490	COG0719	Fe-S assembly protein
tll0495	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
tll0500	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
tll0502	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
tll0506	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
tll0507	COG1834	amidinotransferase
tll0513	COG1840	ABC-type Fe3 transport system, periplasmic component
tll0517	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
tll0518	COG0470	DNA polymerase III
tll0519	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
tll0519	COG0617	tRNA 3'-terminal CCA addition
tll0519	COG0517	IMP dehydrogenase activity
tll0523	COG1181	Belongs to the D-alanine--D-alanine ligase family
tll0527	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
tll0529	COG0312	modulator of DNA gyrase
tll0530	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
tll0531	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
tll0539	COG3429	Glucose-6-phosphate dehydrogenase subunit
tll0539	COG3409	Peptidoglycan-binding domain 1 protein
tll0540	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
tll0541	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
tll0553	COG4251	negative regulation of phosphorylation
tll0559	COG1132	(ABC) transporter
tll0562	COG0693	protein deglycase activity
tll0565	COG0123	including yeast histone deacetylase and acetoin utilization protein
tll0568	COG0784	Response regulator, receiver
tll0568	COG0643	Histidine kinase
tll0568	COG2198	Histidine kinase
tll0569	COG2203	Gaf domain
tll0569	COG0840	transmembrane signaling receptor activity
tll0572	COG0784	Response regulator, receiver
tll0573	COG3659	wide pore channel activity
tll0574	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
tll0578	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
tll0579	COG0167	dihydroorotate dehydrogenase activity
tll0581	COG1122	ATPase activity
tll0583	COG0574	Belongs to the PEP-utilizing enzyme family
tll0583	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
tll0584	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
tll0586	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
tll0590	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
tll0600	COG0706	membrane insertase activity
tll0601	COG0594	ribonuclease P activity
tll0614	COG0783	Belongs to the Dps family
tll0617	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
tll0623	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
tll0627	COG5001	Diguanylate cyclase
tll0627	COG1716	ATPase activity
tll0633	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
tll0634	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
tll0639	COG0501	Belongs to the peptidase M48B family
tll0640	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
tll0641	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
tll0642	COG0085	RNA polymerase activity
tll0643	COG0577	efflux transmembrane transporter activity
tll0643	COG1136	(ABC) transporter
tll0645	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
tll0647	COG1372	Participates in initiation and elongation during chromosome replication
tll0647	COG0187	DNA topoisomerase II activity
tll0657	COG2217	Heavy metal translocating P-type atpase
tll0661	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
tll0662	COG0072	phenylalanine-tRNA ligase activity
tll0662	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
tll0663	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
tll0664	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
tll0665	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
tll0666	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
tll0683	COG1333	cytochrome c biogenesis protein
tll0684	COG0408	coproporphyrinogen oxidase activity
tll0697	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
tll0698	COG0134	indole-3-glycerol-phosphate synthase activity
tll0717	COG0166	Belongs to the GPI family
tll0719	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
tll0720	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
tll0730	COG0251	oxidation-reduction process
tll0734	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
tll0735	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
tll0745	COG0404	The glycine cleavage system catalyzes the degradation of glycine
tll0746	COG1331	Highly conserved protein containing a thioredoxin domain
tll0759	COG1175	transmembrane transport
tll0760	COG0505	Belongs to the CarA family
tll0761	COG1420	regulation of RNA biosynthetic process
tll0763	COG0297	glycogen (starch) synthase activity
tll0768	COG0504	CTP synthase activity
tll0771	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
tll0772	COG0697	spore germination
tll0780	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
tll0787	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
tll0790	COG0484	heat shock protein binding
tll0791	COG0443	Heat shock 70 kDa protein
tll0793	COG1666	GTP binding
tll0808	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
tll0810	COG0747	negative chemotaxis
tll0812	COG3118	belongs to the thioredoxin family
tll0815	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
tll0815	COG0678	peroxiredoxin activity
tll0819	COG1121	(ABC) transporter
tll0824	COG0717	Belongs to the dCTP deaminase family
tll0826	COG0018	arginyl-trna synthetase
tll0831	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
tll0832	COG0321	lipoyl(octanoyl) transferase activity
tll0857	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
tll0858	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
tll0867	COG0316	Belongs to the HesB IscA family
tll0868	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
tll0869	COG2006	4fe-4S ferredoxin, iron-sulfur binding domain protein
tll0874	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
tll0876	COG2205	protein histidine kinase activity
tll0876	COG0784	Response regulator, receiver
tll0876	COG5002	protein histidine kinase activity
tll0880	COG0440	acetolactate synthase activity
tll0885	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
tll0887	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
tll0891	COG0275	rRNA processing
tll0895	COG0602	queuosine metabolic process
tll0899	COG2205	protein histidine kinase activity
tll0913	COG1104	cysteine desulfurase activity
tll0915	COG1234	tRNA 3'-trailer cleavage
tll0915	COG1555	photosystem II stabilization
tll0918	COG0596	Alpha beta hydrolase
tll0922	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
tll0925	COG5002	protein histidine kinase activity
tll0931	COG1028	Short-chain dehydrogenase reductase Sdr
tll0933	COG0741	lytic transglycosylase activity
tll0943	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
tll0944	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
tll0944	COG4451	ribulose bisphosphate carboxylase, small
tll0945	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
tll0946	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
tll0947	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
tll0950	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
tll0952	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
tll0970	COG1063	alcohol dehydrogenase
tll0971	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
tll0978	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
tll0980	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
tll0985	COG1253	flavin adenine dinucleotide binding
tll0987	COG1162	GTPase activity
tll0990	COG1882	Formate acetyltransferase
tll0991	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
tll0993	COG1216	Glycosyl transferase, family 2
tll0995	COG1442	glycosyl transferase family 8
tll0995	COG1216	Glycosyl transferase, family 2
tll1003	COG0154	amidase activity
tll1015	COG1216	Glycosyl transferase, family 2
tll1019	COG4968	Prepilin-type N-terminal cleavage methylation domain
tll1022	COG0840	transmembrane signaling receptor activity
tll1022	COG2203	Gaf domain
tll1027	COG1410	methionine synthase
tll1027	COG0646	methionine synthase
tll1029	COG0702	epimerase
tll1031	COG0163	prenyltransferase activity
tll1033	COG0726	polysaccharide deacetylase
tll1034	COG0752	glycyl-tRNA synthetase alpha subunit
tll1035	COG0175	sulfate reduction
tll1037	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
tll1042	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
tll1043	COG1472	Belongs to the glycosyl hydrolase 3 family
tll1044	COG2046	Belongs to the sulfate adenylyltransferase family
tll1048	COG0745	RESPONSE REGULATOR receiver
tll1057	COG0129	dihydroxy-acid dehydratase activity
tll1061	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
tll1089	COG2166	iron-sulfur cluster assembly
tll1106	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
tll1107	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
tll1111	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
tll1111	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
tll1144	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
tll1148	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
tll1149	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
tll1155	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
tll1181	COG0339	signal peptide processing
tll1182	COG0739	heme binding
tll1183	COG0768	penicillin binding
tll1186	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
tll1187	COG0084	hydrolase, TatD family'
tll1189	COG1691	(AIR) carboxylase
tll1192	COG0635	Involved in the biosynthesis of porphyrin-containing compound
tll1193	COG1615	UPF0182 protein
tll1195	COG0457	Tetratricopeptide repeat
tll1201	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
tll1202	COG0297	glycogen (starch) synthase activity
tll1202	COG0438	transferase activity, transferring glycosyl groups
tll1205	COG1357	PFAM Pentapeptide repeats (8 copies)
tll1205	COG0515	serine threonine protein kinase
tll1221	COG0318	PFAM AMP-dependent synthetase and ligase
tll1225	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
tll1227	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
tll1237	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
tll1241	COG1606	tRNA processing
tll1243	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
tll1243	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
tll1269	COG3631	Ketosteroid isomerase-related protein
tll1273	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
tll1275	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
tll1276	COG1494	fructose-1,6-bisphosphatase
tll1278	COG0179	Fumarylacetoacetate (FAA) hydrolase
tll1282	COG2205	protein histidine kinase activity
tll1282	COG5002	protein histidine kinase activity
tll1282	COG0784	Response regulator, receiver
tll1283	COG2010	Cytochrome c
tll1284	COG2010	Cytochrome c
tll1285	COG2010	Cytochrome c
tll1291	COG1070	Carbohydrate kinase
tll1297	COG1649	PFAM Uncharacterised BCR, COG1649
tll1298	COG1122	ATPase activity
tll1299	COG0508	dehydrogenase complex catalyzes the overall conversion of
tll1304	COG1994	Peptidase M50
tll1304	COG0517	IMP dehydrogenase activity
tll1309	COG0302	gtp cyclohydrolase
tll1310	COG1028	Short-chain dehydrogenase reductase Sdr
tll1311	COG0825	malonyl-CoA metabolic process
tll1312	COG5322	oxidoreductase activity
tll1313	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
tll1316	COG0205	6-phosphofructokinase activity
tll1329	COG1131	(ABC) transporter
tll1329	COG0842	Transport permease protein
tll1329	COG1716	ATPase activity
tll1337	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
tll1338	COG0612	Peptidase, M16
tll1339	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
tll1339	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
tll1340	COG0842	Transport permease protein
tll1340	COG1716	ATPase activity
tll1340	COG1131	(ABC) transporter
tll1358	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
tll1359	COG0583	DNA-binding transcription factor activity
tll1360	COG0314	molybdopterin synthase activity
tll1362	COG0315	cyclic pyranopterin monophosphate synthase activity
tll1362	COG0746	molybdenum cofactor guanylyltransferase activity
tll1363	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
tll1364	COG0303	'Molybdopterin
tll1365	COG0830	nickel cation binding
tll1366	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
tll1367	COG2205	protein histidine kinase activity
tll1367	COG0784	Response regulator, receiver
tll1368	COG0067	glutamate synthase
tll1368	COG0069	glutamate synthase activity
tll1368	COG0070	glutamate synthase
tll1373	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
tll1373	COG0426	domain, Protein
tll1382	COG0395	ABC-type sugar transport system, permease component
tll1383	COG0577	efflux transmembrane transporter activity
tll1383	COG1136	(ABC) transporter
tll1384	COG0193	aminoacyl-tRNA hydrolase activity
tll1397	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
tll1398	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
tll1401	COG0121	glutamine amidotransferase
tll1403	COG1304	FMN binding
tll1405	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
tll1406	COG0793	Belongs to the peptidase S41A family
tll1408	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
tll1411	COG2340	Cysteine-rich secretory protein family
tll1413	COG1240	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
tll1413	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
tll1418	COG0310	cobalt ion transport
tll1451	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
tll1454	COG0450	alkyl hydroperoxide reductase
tll1457	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
tll1462	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
tll1466	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
tll1486	COG0515	serine threonine protein kinase
tll1488	COG1716	ATPase activity
tll1492	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
tll1495	COG0837	glucose binding
tll1496	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
tll1504	COG4451	ribulose bisphosphate carboxylase, small
tll1506	COG1850	ribulose-bisphosphate carboxylase activity
tll1511	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
tll1515	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
tll1525	COG0457	Tetratricopeptide repeat
tll1534	COG0114	fumarate hydratase activity
tll1538	COG0564	pseudouridine synthase activity
tll1539	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
tll1545	COG1175	transmembrane transport
tll1555	COG0714	Associated with various cellular activities
tll1556	COG0196	riboflavin kinase activity
tll1558	COG0540	Belongs to the ATCase OTCase family
tll1559	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
tll1560	COG1562	ergosterol biosynthetic process
tll1561	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
tll1561	COG0493	'glutamate synthase
tll1566	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
tll1569	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
tll1571	COG1137	ATPase activity
tll1587	COG0012	GTP binding
tll1588	COG0174	glutamine synthetase
tll1590	COG0438	transferase activity, transferring glycosyl groups
tll1591	COG0438	transferase activity, transferring glycosyl groups
tll1596	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
tll1601	COG1294	oxidase, subunit
tll1602	COG1271	oxidase subunit
tll1603	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
tll1603	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
tll1604	COG2226	methyltransferase
tll1608	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
tll1617	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
tll1619	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
tll1622	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
tll1622	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
tll1625	COG0277	FAD linked oxidase domain protein
tll1629	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
tll1633	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
tll1634	COG4783	chaperone-mediated protein folding
tll1639	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
tll1641	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
tll1642	COG0750	zinc metalloprotease
tll1646	COG0181	hydroxymethylbilane synthase activity
tll1650	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
tll1659	COG5002	protein histidine kinase activity
tll1663	COG0247	lactate metabolic process
tll1664	COG0277	FAD linked oxidase domain protein
tll1667	COG0815	Transfers the fatty acyl group on membrane lipoproteins
tll1671	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
tll1672	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
tll1687	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
tll1688	COG0052	Belongs to the universal ribosomal protein uS2 family
tll1692	COG1842	Phage shock protein A
tll1693	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
tll1695	COG4447	cellulose binding
tll1696	COG1773	rubredoxin
tll1704	COG0357	Ribosomal RNA small subunit methyltransferase G
tll1706	COG3659	wide pore channel activity
tll1708	COG2326	polyphosphate kinase activity
tll1712	COG1178	ABC-type Fe3 transport system permease component
tll1713	COG0157	Belongs to the NadC ModD family
tll1714	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
tll1716	COG1492	cobalamin metabolic process
tll1721	COG5398	heme oxygenase
tll1726	COG2226	methyltransferase
tll1737	COG0792	nuclease activity
tll1738	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
tll1742	COG3977	Valine--pyruvate aminotransferase
tll1759	COG0740	serine-type endopeptidase activity
tll1772	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
tll1774	COG0860	N-Acetylmuramoyl-L-alanine amidase
tll1777	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
tll1784	COG4372	Transposase
tll1786	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
tll1797	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
tll1800	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
tll1801	COG2843	Capsule synthesis protein
tll1802	COG0517	IMP dehydrogenase activity
tll1802	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
tll1804	COG0616	signal peptide processing
tll1807	COG1166	arginine decarboxylase activity
tll1817	COG0651	ATP synthesis coupled electron transport
tll1826	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
tll1829	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
tll1831	COG1716	ATPase activity
tll1831	COG5001	Diguanylate cyclase
tll1832	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
tll1842	COG0003	Pfam Anion-transporting ATPase
tll1845	COG1035	Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus
tll1851	COG0653	protein targeting
tll1867	COG3906	Belongs to the UPF0473 family
tll1870	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
tll1871	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
tll1881	COG1754	DNA topoisomerase type I activity
tll1881	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
tll1883	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
tll1888	COG0789	Transcriptional regulator
tll1891	COG4221	oxidoreductase activity
tll1893	COG0109	protoheme IX farnesyltransferase activity
tll1894	COG1612	heme a metabolic process
tll1898	COG0124	histidyl-tRNA synthetase
tll1899	COG0497	DNA recombination
tll1907	COG3128	pkhd-type hydroxylase
tll1909	COG5002	protein histidine kinase activity
tll1911	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
tll1912	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
tll1914	COG0572	uridine kinase
tll1920	COG2217	Heavy metal translocating P-type atpase
tll1923	COG0730	response to heat
tll1924	COG0492	ferredoxin-NADP+ reductase activity
tll1927	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
tll1935	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
tll1937	COG0195	Participates in both transcription termination and antitermination
tll1938	COG0779	Required for maturation of 30S ribosomal subunits
tll1940	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
tll1956	COG1573	uracil-dna glycosylase
tll1968	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
tll1970	COG0525	valine-tRNA ligase activity
tll1971	COG2308	Evidence 4 Homologs of previously reported genes of
tll1974	COG1543	Belongs to the glycosyl hydrolase 57 family
tll1975	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
tll1983	COG0220	tRNA (guanine-N7-)-methyltransferase activity
tll1985	COG0004	ammonium transporteR
tll1987	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
tll2030	COG0598	Magnesium transport protein CorA
tll2039	COG0170	dolichyl monophosphate biosynthetic process
tll2040	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
tll2043	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
tll2045	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
tll2046	COG0539	negative regulation of cytoplasmic translation
tll2049	COG3158	transport of potassium into the cell
tll2050	COG0436	Aminotransferase
tll2051	COG0371	Dehydrogenase
tll2053	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
tll2056	COG0587	DNA-directed DNA polymerase activity
tll2069	COG0587	DNA-directed DNA polymerase activity
tll2077	COG3932	Exopolysaccharide synthesis, ExoD
tll2079	COG0058	SHG alpha-glucan phosphorylase activity
tll2087	COG3118	belongs to the thioredoxin family
tll2093	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
tll2098	COG0495	leucyl-tRNA aminoacylation
tll2102	COG0436	Aminotransferase
tll2103	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
tll2108	COG0575	Belongs to the CDS family
tll2111	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
tll2114	COG0411	ABC transporter
tll2116	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
tll2117	COG1725	Transcriptional regulator
tll2118	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
tll2145	COG3937	granule-associated protein
tll2147	COG2094	Belongs to the DNA glycosylase MPG family
tll2149	COG0484	heat shock protein binding
tll2150	COG0443	Heat shock 70 kDa protein
tll2157	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
tll2158	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
tll2178	COG1028	Short-chain dehydrogenase reductase Sdr
tll2183	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
tll2183	COG0546	phosphoglycolate phosphatase activity
tll2190	COG0516	GMP reductase activity
tll2192	COG0751	glycine-tRNA ligase activity
tll2193	COG1185	polyribonucleotide nucleotidyltransferase activity
tll2201	COG0778	Nitroreductase
tll2202	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
tll2204	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
tll2205	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
tll2215	COG0443	Heat shock 70 kDa protein
tll2219	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
tll2222	COG2815	serine threonine protein kinase
tll2222	COG0515	serine threonine protein kinase
tll2224	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
tll2227	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
tll2230	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
tll2252	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
tll2253	COG2255	four-way junction helicase activity
tll2254	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
tll2265	COG0006	proline dipeptidase activity
tll2266	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
tll2267	COG0776	regulation of translation
tll2268	COG0126	phosphoglycerate kinase activity
tll2272	COG0135	phosphoribosylanthranilate isomerase activity
tll2275	COG0469	pyruvate kinase activity
tll2285	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
tll2291	COG5505	Protein of unknown function (DUF819)
tll2294	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
tll2296	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
tll2306	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
tll2307	COG1496	oxidoreductase activity
tll2310	COG4783	chaperone-mediated protein folding
tll2320	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
tll2327	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
tll2329	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
tll2332	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
tll2345	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
tll2347	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
tll2349	COG0592	DNA-directed DNA polymerase activity
tll2350	COG0728	peptidoglycan biosynthetic process
tll2351	COG5002	protein histidine kinase activity
tll2353	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
tll2357	COG0436	Aminotransferase
tll2359	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
tll2364	COG0745	RESPONSE REGULATOR receiver
tll2365	COG0237	dephospho-CoA kinase activity
tll2365	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
tll2366	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
tll2369	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
tll2372	COG0589	response to stress
tll2373	COG2226	methyltransferase
tll2382	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
tll2383	COG1108	ABC-type Mn2 Zn2 transport systems permease components
tll2385	COG3385	transposase activity
tll2390	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
tll2392	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
tll2395	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
tll2395	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
tll2396	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
tll2408	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
tll2409	COG1555	photosystem II stabilization
tll2418	COG0518	GMP synthase (glutamine-hydrolyzing) activity
tll2418	COG0519	Catalyzes the synthesis of GMP from XMP
tll2421	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
tll2425	COG0820	rRNA (adenine-C2-)-methyltransferase activity
tll2427	COG0463	Glycosyl transferase, family 2
tll2427	COG0457	Tetratricopeptide repeat
tll2429	COG2010	Cytochrome c
tll2435	COG0287	Prephenate dehydrogenase
tll2439	COG1122	ATPase activity
tll2441	COG1930	Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import
tll2442	COG0310	cobalt ion transport
tll2444	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
tll2447	COG1473	amidohydrolase
tll2450	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
tll2450	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
tll2453	COG0542	response to heat
tll2463	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
tll2466	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
tll2467	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
tll2474	COG0475	glutathione-regulated potassium exporter activity
tll2474	COG0589	response to stress
tll2475	COG0133	tryptophan synthase activity
tlr0005	COG0804	urea catabolic process
tlr0029	COG2205	protein histidine kinase activity
tlr0031	COG3344	reverse transcriptase
tlr0041	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
tlr0042	COG0204	Acyl-transferase
tlr0042	COG0318	PFAM AMP-dependent synthetase and ligase
tlr0050	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
tlr0051	COG0612	Peptidase, M16
tlr0055	COG0848	biopolymer transport protein
tlr0056	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
tlr0057	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
tlr0058	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
tlr0067	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
tlr0069	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
tlr0081	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
tlr0082	COG0088	Forms part of the polypeptide exit tunnel
tlr0083	COG0089	rRNA binding
tlr0084	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
tlr0086	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
tlr0087	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
tlr0088	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
tlr0091	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
tlr0092	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
tlr0093	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
tlr0094	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
tlr0095	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
tlr0096	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
tlr0097	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
tlr0098	COG0200	Binds to the 23S rRNA
tlr0099	COG0201	protein transport
tlr0100	COG0563	adenylate kinase activity
tlr0103	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
tlr0104	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
tlr0105	COG0202	RNA polymerase activity
tlr0106	COG0203	ribosomal protein L17
tlr0107	COG0101	tRNA pseudouridine synthase activity
tlr0108	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
tlr0109	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
tlr0111	COG2957	Belongs to the agmatine deiminase family
tlr0115	COG1104	cysteine desulfurase activity
tlr0132	COG0484	heat shock protein binding
tlr0137	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
tlr0140	COG2814	Major facilitator Superfamily
tlr0143	COG0009	L-threonylcarbamoyladenylate synthase
tlr0144	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
tlr0147	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
tlr0148	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
tlr0151	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
tlr0152	COG1132	(ABC) transporter
tlr0160	COG3411	Ferredoxin
tlr0174	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
tlr0174	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
tlr0179	COG0434	BtpA family
tlr0190	COG0285	dihydrofolate synthase activity
tlr0192	COG0735	belongs to the Fur family
tlr0195	COG2205	protein histidine kinase activity
tlr0206	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
tlr0207	COG0625	glutathione transferase activity
tlr0209	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
tlr0209	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
tlr0213	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
tlr0221	COG1012	belongs to the aldehyde dehydrogenase family
tlr0226	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
tlr0227	COG1012	belongs to the aldehyde dehydrogenase family
tlr0227	COG1454	alcohol dehydrogenase
tlr0228	COG0095	Lipoate-protein ligase
tlr0241	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
tlr0242	COG0438	transferase activity, transferring glycosyl groups
tlr0244	COG0367	asparagine synthase
tlr0247	COG3385	transposase activity
tlr0261	COG0745	RESPONSE REGULATOR receiver
tlr0263	COG2268	Band 7 protein
tlr0264	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
tlr0267	COG0105	UTP biosynthetic process
tlr0271	COG1429	ligase activity, forming nitrogen-metal bonds
tlr0274	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
tlr0275	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
tlr0276	COG4208	sulfate ABC transporter
tlr0279	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
tlr0281	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
tlr0283	COG1842	Phage shock protein A
tlr0284	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
tlr0285	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
tlr0289	COG0629	single-stranded DNA binding
tlr0294	COG0250	Participates in transcription elongation, termination and antitermination
tlr0295	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
tlr0296	COG0081	regulation of translation
tlr0297	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
tlr0298	COG0222	ribosome binding
tlr0299	COG0328	RNA-DNA hybrid ribonuclease activity
tlr0304	COG0481	GTPase activity
tlr0308	COG3344	reverse transcriptase
tlr0310	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
tlr0311	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
tlr0317	COG1595	DNA-templated transcription, initiation
tlr0324	COG0484	heat shock protein binding
tlr0325	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
tlr0326	COG2264	protein methyltransferase activity
tlr0333	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
tlr0334	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
tlr0339	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
tlr0343	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
tlr0348	COG0840	transmembrane signaling receptor activity
tlr0349	COG0784	Response regulator, receiver
tlr0349	COG0643	Histidine kinase
tlr0349	COG2198	Histidine kinase
tlr0350	COG4581	dead DEAH box helicase
tlr0355	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
tlr0364	COG0312	modulator of DNA gyrase
tlr0374	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
tlr0379	COG2119	membrane
tlr0393	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
tlr0402	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
tlr0405	COG0681	Belongs to the peptidase S26 family
tlr0408	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
tlr0412	COG0569	domain protein
tlr0416	COG1012	belongs to the aldehyde dehydrogenase family
tlr0421	COG0431	NADPH-dependent FMN reductase
tlr0428	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
tlr0430	COG0356	it plays a direct role in the translocation of protons across the membrane
tlr0431	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
tlr0432	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
tlr0433	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
tlr0434	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
tlr0435	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
tlr0436	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
tlr0437	COG5002	protein histidine kinase activity
tlr0440	COG0772	Belongs to the SEDS family
tlr0445	COG0515	serine threonine protein kinase
tlr0449	COG0475	glutathione-regulated potassium exporter activity
tlr0450	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
tlr0461	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
tlr0479	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
tlr0484	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
tlr0485	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
tlr0494	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
tlr0497	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
tlr0499	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
tlr0501	COG1108	ABC-type Mn2 Zn2 transport systems permease components
tlr0503	COG1959	2 iron, 2 sulfur cluster binding
tlr0504	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
tlr0508	COG0544	peptidyl-prolyl cis-trans isomerase activity
tlr0509	COG0740	serine-type endopeptidase activity
tlr0510	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
tlr0516	COG0469	pyruvate kinase activity
tlr0522	COG3344	reverse transcriptase
tlr0525	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
tlr0526	COG0355	proton-transporting ATP synthase activity, rotational mechanism
tlr0528	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
tlr0532	COG0632	four-way junction helicase activity
tlr0535	COG0445	tRNA wobble uridine modification
tlr0536	COG0829	nickel cation binding
tlr0551	COG2172	sigma factor antagonist activity
tlr0575	COG1028	Short-chain dehydrogenase reductase Sdr
tlr0576	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
tlr0577	COG1132	(ABC) transporter
tlr0582	COG0438	transferase activity, transferring glycosyl groups
tlr0587	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
tlr0589	COG0745	RESPONSE REGULATOR receiver
tlr0592	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
tlr0597	COG1530	ribonuclease E activity
tlr0598	COG2066	Belongs to the glutaminase family
tlr0603	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
tlr0605	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
tlr0611	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
tlr0612	COG0701	Predicted permease
tlr0613	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
tlr0620	COG3344	reverse transcriptase
tlr0626	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
tlr0628	COG0612	Peptidase, M16
tlr0648	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
tlr0652	COG0557	exoribonuclease II activity
tlr0655	COG1132	(ABC) transporter
tlr0656	COG1187	pseudouridine synthase activity
tlr0658	COG0148	phosphopyruvate hydratase activity
tlr0659	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
tlr0667	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
tlr0668	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
tlr0669	COG0839	Belongs to the complex I subunit 6 family
tlr0670	COG0713	ATP synthesis coupled electron transport
tlr0671	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
tlr0672	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
tlr0690	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
tlr0691	COG1192	Involved in chromosome partitioning
tlr0693	COG1049	propionate catabolic process, 2-methylcitrate cycle
tlr0699	COG3046	protein related to deoxyribodipyrimidine photolyase
tlr0700	COG3046	protein related to deoxyribodipyrimidine photolyase
tlr0701	COG3046	protein related to deoxyribodipyrimidine photolyase
tlr0704	COG1446	asparaginase
tlr0705	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
tlr0708	COG1640	4-alpha-glucanotransferase
tlr0711	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
tlr0712	COG0137	argininosuccinate synthase activity
tlr0715	COG0617	tRNA 3'-terminal CCA addition
tlr0723	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
tlr0731	COG2885	chlorophyll binding
tlr0732	COG2885	chlorophyll binding
tlr0733	COG0668	transmembrane transport
tlr0737	COG1968	undecaprenyl-diphosphatase activity
tlr0738	COG1191	sigma factor activity
tlr0740	COG3854	ATPases associated with a variety of cellular activities
tlr0741	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
tlr0750	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
tlr0758	COG0484	heat shock protein binding
tlr0764	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
tlr0765	COG0574	Belongs to the PEP-utilizing enzyme family
tlr0765	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
tlr0767	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
tlr0777	COG0442	prolyl-tRNA aminoacylation
tlr0782	COG0058	SHG alpha-glucan phosphorylase activity
tlr0783	COG2223	nitrite transmembrane transporter activity
tlr0784	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
tlr0800	COG0514	ATP-dependent DNA helicase (RecQ)
tlr0803	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
tlr0809	COG3956	TIGRFAM MazG family protein
tlr0816	COG2217	Heavy metal translocating P-type atpase
tlr0818	COG1899	peptidyl-lysine modification to peptidyl-hypusine
tlr0821	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
tlr0823	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
tlr0829	COG3264	Mechanosensitive ion channel
tlr0829	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
tlr0833	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
tlr0838	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
tlr0843	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
tlr0844	COG0416	fatty acid biosynthetic process
tlr0845	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
tlr0850	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
tlr0851	COG1045	serine acetyltransferase
tlr0861	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
tlr0873	COG0071	Belongs to the small heat shock protein (HSP20) family
tlr0878	COG1160	GTP binding
tlr0882	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
tlr0892	COG1116	anion transmembrane transporter activity
tlr0898	COG0237	dephospho-CoA kinase activity
tlr0904	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
tlr0905	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
tlr0908	COG0189	ligase activity
tlr0909	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
tlr0924	COG4251	negative regulation of phosphorylation
tlr0924	COG3706	GGDEF domain
tlr0924	COG5001	Diguanylate cyclase
tlr0924	COG2203	Gaf domain
tlr0927	COG1218	3'(2'),5'-bisphosphate nucleotidase
tlr0928	COG0552	protein localization to endoplasmic reticulum
tlr0930	COG0436	Aminotransferase
tlr0942	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
tlr0951	COG1091	dTDP-4-dehydrorhamnose reductase activity
tlr0953	COG0805	protein transport
tlr0954	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
tlr0962	COG1132	(ABC) transporter
tlr0963	COG1192	Involved in chromosome partitioning
tlr0966	COG0149	triose-phosphate isomerase activity
tlr0969	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
tlr0974	COG4245	von Willebrand factor, type A
tlr0979	COG2048	Heterodisulfide reductase, subunit B
tlr0981	COG0831	urea catabolic process
tlr0982	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
tlr0996	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
tlr0997	COG0537	adenosine 5'-monophosphoramidase activity
tlr0998	COG3344	reverse transcriptase
tlr1005	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
tlr1018	COG0640	Transcriptional regulator
tlr1040	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
tlr1041	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
tlr1045	COG1073	alpha beta
tlr1045	COG2226	methyltransferase
tlr1047	COG0438	transferase activity, transferring glycosyl groups
tlr1053	COG0742	ribosomal rna small subunit methyltransferase
tlr1054	COG0667	Aldo Keto reductase
tlr1056	COG2099	Precorrin-6x reductase
tlr1065	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
tlr1066	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
tlr1067	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
tlr1070	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
tlr1071	COG0740	serine-type endopeptidase activity
tlr1076	COG0363	glucosamine-6-phosphate deaminase activity
tlr1079	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
tlr1088	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
tlr1088	COG0426	domain, Protein
tlr1090	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
tlr1098	COG0515	serine threonine protein kinase
tlr1098	COG1357	PFAM Pentapeptide repeats (8 copies)
tlr1103	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
tlr1121	COG0559	Belongs to the binding-protein-dependent transport system permease family
tlr1122	COG0559	Belongs to the binding-protein-dependent transport system permease family
tlr1123	COG0411	ABC transporter
tlr1128	COG0515	serine threonine protein kinase
tlr1128	COG1357	PFAM Pentapeptide repeats (8 copies)
tlr1132	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
tlr1136	COG1252	NADH dehydrogenase
tlr1137	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
tlr1146	COG0668	transmembrane transport
tlr1147	COG2081	HI0933 family
tlr1151	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
tlr1153	COG0745	RESPONSE REGULATOR receiver
tlr1157	COG0596	Alpha beta hydrolase
tlr1158	COG3706	GGDEF domain
tlr1159	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
tlr1161	COG3344	reverse transcriptase
tlr1165	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
tlr1169	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
tlr1171	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
tlr1174	COG1441	menaquinone biosynthetic process
tlr1178	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
tlr1180	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
tlr1180	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
tlr1185	COG0107	imidazoleglycerol-phosphate synthase activity
tlr1194	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
tlr1197	COG0601	transmembrane transport
tlr1198	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
tlr1206	COG0583	DNA-binding transcription factor activity
tlr1210	COG3706	GGDEF domain
tlr1211	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
tlr1214	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
tlr1215	COG2205	protein histidine kinase activity
tlr1215	COG0784	Response regulator, receiver
tlr1215	COG5002	protein histidine kinase activity
tlr1216	COG1799	cell septum assembly
tlr1217	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
tlr1219	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
tlr1220	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
tlr1222	COG0799	negative regulation of ribosome biogenesis
tlr1224	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
tlr1228	COG0588	phosphoglycerate mutase activity
tlr1233	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
tlr1234	COG0066	3-isopropylmalate dehydratase activity
tlr1239	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
tlr1246	COG3659	wide pore channel activity
tlr1253	COG1716	ATPase activity
tlr1253	COG1131	(ABC) transporter
tlr1253	COG0842	Transport permease protein
tlr1258	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
tlr1261	COG0601	transmembrane transport
tlr1263	COG0745	RESPONSE REGULATOR receiver
tlr1266	COG2062	phosphohistidine phosphatase, SixA
tlr1279	COG0360	Binds together with S18 to 16S ribosomal RNA
tlr1281	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
tlr1287	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
tlr1288	COG0649	NAD binding
tlr1290	COG1160	GTP binding
tlr1294	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
tlr1295	COG0511	ligase activity, forming carbon-carbon bonds
tlr1296	COG0028	Belongs to the TPP enzyme family
tlr1302	COG0424	maF-like protein
tlr1303	COG0335	large ribosomal subunit rRNA binding
tlr1314	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
tlr1315	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
tlr1317	COG0358	DNA primase activity
tlr1326	COG1357	PFAM Pentapeptide repeats (8 copies)
tlr1326	COG0515	serine threonine protein kinase
tlr1328	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
tlr1330	COG0745	RESPONSE REGULATOR receiver
tlr1331	COG0156	8-amino-7-oxononanoate synthase activity
tlr1341	COG0529	Catalyzes the synthesis of activated sulfate
tlr1344	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
tlr1349	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
tlr1350	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
tlr1351	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
tlr1352	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
tlr1352	COG1116	anion transmembrane transporter activity
tlr1354	COG1116	anion transmembrane transporter activity
tlr1355	COG0243	molybdopterin cofactor binding
tlr1369	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
tlr1370	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
tlr1389	COG0542	response to heat
tlr1412	COG0459	protein refolding
tlr1421	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
tlr1423	COG0412	Dienelactone hydrolase
tlr1424	COG3063	Type IV pilus biogenesis stability protein PilW
tlr1426	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
tlr1429	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
tlr1430	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
tlr1431	COG0758	DNA mediated transformation
tlr1431	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
tlr1436	COG1063	alcohol dehydrogenase
tlr1445	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
tlr1448	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
tlr1460	COG0515	serine threonine protein kinase
tlr1460	COG3266	domain, Protein
tlr1471	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
tlr1471	COG0512	Glutamine amidotransferase of anthranilate synthase
tlr1473	COG1131	(ABC) transporter
tlr1490	COG0629	single-stranded DNA binding
tlr1498	COG2319	Wd-40 repeat
tlr1498	COG1672	PFAM Archaeal ATPase
tlr1502	COG1028	Short-chain dehydrogenase reductase Sdr
tlr1503	COG0525	valine-tRNA ligase activity
tlr1514	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
tlr1520	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
tlr1521	COG2211	Major facilitator Superfamily
tlr1522	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
tlr1526	COG0589	response to stress
tlr1532	COG0406	alpha-ribazole phosphatase activity
tlr1533	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
tlr1536	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
tlr1540	COG0515	serine threonine protein kinase
tlr1540	COG1357	PFAM Pentapeptide repeats (8 copies)
tlr1546	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
tlr1547	COG0138	bifunctional purine biosynthesis protein purh
tlr1552	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
tlr1553	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
tlr1564	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
tlr1568	COG1366	Belongs to the anti-sigma-factor antagonist family
tlr1577	COG0762	integral membrane protein
tlr1583	COG0772	Belongs to the SEDS family
tlr1585	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
tlr1586	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
tlr1594	COG0515	serine threonine protein kinase
tlr1597	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
tlr1600	COG0473	3-isopropylmalate dehydrogenase activity
tlr1606	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
tlr1607	COG0793	Belongs to the peptidase S41A family
tlr1611	COG0336	Belongs to the RNA methyltransferase TrmD family
tlr1612	COG5001	Diguanylate cyclase
tlr1613	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
tlr1615	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
tlr1616	COG0037	tRNA processing
tlr1620	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
tlr1627	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
tlr1636	COG1218	3'(2'),5'-bisphosphate nucleotidase
tlr1637	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
tlr1643	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
tlr1656	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
tlr1657	COG0483	inositol monophosphate 1-phosphatase activity
tlr1660	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
tlr1676	COG0242	peptide deformylase activity
tlr1678	COG0509	glycine decarboxylation via glycine cleavage system
tlr1679	COG0559	Belongs to the binding-protein-dependent transport system permease family
tlr1682	COG0454	-acetyltransferase
tlr1683	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
tlr1684	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
tlr1689	COG1192	Involved in chromosome partitioning
tlr1690	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
tlr1697	COG1489	DNA binding
tlr1707	COG2003	Belongs to the UPF0758 family
tlr1710	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
tlr1722	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
tlr1727	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
tlr1727	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
tlr1732	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
tlr1733	COG0443	Heat shock 70 kDa protein
tlr1736	COG3264	Mechanosensitive ion channel
tlr1736	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
tlr1741	COG1528	Iron-storage protein
tlr1743	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
tlr1745	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
tlr1746	COG1385	rRNA (uridine-N3-)-methyltransferase activity
tlr1747	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
tlr1748	COG0049	tRNA binding
tlr1749	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
tlr1750	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
tlr1751	COG0051	transcription antitermination factor activity, RNA binding
tlr1753	COG0322	excinuclease ABC activity
tlr1754	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
tlr1756	COG3842	ATPase activity
tlr1757	COG0142	geranyltranstransferase activity
tlr1758	COG1316	TRANSCRIPTIONal
tlr1761	COG0019	diaminopimelate decarboxylase activity
tlr1763	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
tlr1764	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
tlr1765	COG0083	homoserine kinase activity
tlr1769	COG1136	(ABC) transporter
tlr1773	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
tlr1773	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
tlr1790	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
tlr1791	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
tlr1792	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
tlr1793	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
tlr1795	COG1215	transferase activity, transferring glycosyl groups
tlr1799	COG4636	protein conserved in cyanobacteria
tlr1808	COG0439	Biotin carboxylase
tlr1809	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
tlr1810	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
tlr1811	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
tlr1819	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
tlr1821	COG3001	Fructosamine kinase
tlr1822	COG0681	Belongs to the peptidase S26 family
tlr1827	COG0215	cysteine-tRNA ligase activity
tlr1828	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
tlr1833	COG0527	aspartate kinase activity
tlr1834	COG0697	spore germination
tlr1836	COG2890	protein-(glutamine-N5) methyltransferase activity
tlr1839	COG0151	Belongs to the GarS family
tlr1848	COG1797	cobyrinic acid a,c-diamide synthase activity
tlr1849	COG0739	heme binding
tlr1854	COG1215	transferase activity, transferring glycosyl groups
tlr1855	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
tlr1861	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
tlr1866	COG1982	Orn Lys Arg decarboxylase major
tlr1873	COG0557	exoribonuclease II activity
tlr1874	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
tlr1876	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
tlr1882	COG1126	abc transporter atp-binding protein
tlr1901	COG1131	(ABC) transporter
tlr1902	COG3693	PFAM glycoside hydrolase, family 10
tlr1904	COG0396	ATPase activity
tlr1905	COG0719	Fe-S assembly protein
tlr1925	COG1196	nuclear chromosome segregation
tlr1928	COG0800	Aldolase
tlr1947	COG0352	thiamine-phosphate diphosphorylase activity
tlr1948	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
tlr1949	COG0354	folic acid binding
tlr1951	COG0391	Required for morphogenesis under gluconeogenic growth conditions
tlr1953	COG2226	methyltransferase
tlr1959	COG0237	dephospho-CoA kinase activity
tlr1961	COG1413	lyase activity
tlr1962	COG1413	lyase activity
tlr1963	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
tlr1964	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
tlr1965	COG0237	dephospho-CoA kinase activity
tlr1966	COG0739	heme binding
tlr1973	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
tlr1976	COG0033	Phosphoglucomutase
tlr1977	COG0420	3'-5' exonuclease activity
tlr1981	COG1234	tRNA 3'-trailer cleavage
tlr1989	COG2205	protein histidine kinase activity
tlr1991	COG1126	abc transporter atp-binding protein
tlr1996	COG0180	Tryptophanyl-tRNA synthetase
tlr2000	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
tlr2001	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
tlr2002	COG1116	anion transmembrane transporter activity
tlr2002	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
tlr2003	COG1116	anion transmembrane transporter activity
tlr2014	COG0515	serine threonine protein kinase
tlr2016	COG0850	regulation of cytokinetic process
tlr2017	COG2894	cell division
tlr2018	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
tlr2020	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
tlr2026	COG0857	belongs to the CobB CobQ family
tlr2033	COG0556	nucleotide-excision repair
tlr2035	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
tlr2037	COG0583	DNA-binding transcription factor activity
tlr2047	COG1970	mechanosensitive ion channel activity
tlr2055	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
tlr2062	COG3443	Belongs to the bacterial solute-binding protein 9 family
tlr2062	COG0803	Belongs to the bacterial solute-binding protein 9 family
tlr2063	COG1121	(ABC) transporter
tlr2066	COG0596	Alpha beta hydrolase
tlr2068	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
tlr2072	COG0275	rRNA processing
tlr2081	COG0714	Associated with various cellular activities
tlr2089	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
tlr2106	COG0077	Prephenate dehydratase
tlr2107	COG0686	Belongs to the AlaDH PNT family
tlr2109	COG1595	DNA-templated transcription, initiation
tlr2119	COG0483	inositol monophosphate 1-phosphatase activity
tlr2124	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
tlr2125	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
tlr2127	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
tlr2128	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
tlr2129	COG1546	Belongs to the CinA family
tlr2129	COG1058	Belongs to the CinA family
tlr2134	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
tlr2146	COG0659	secondary active sulfate transmembrane transporter activity
tlr2152	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
tlr2152	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
tlr2154	COG0739	heme binding
tlr2155	COG1587	Uroporphyrinogen-III synthase
tlr2161	COG2302	S4 RNA-binding domain
tlr2164	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
tlr2165	COG0573	inorganic phosphate transmembrane transporter activity
tlr2166	COG0573	inorganic phosphate transmembrane transporter activity
tlr2167	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
tlr2170	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
tlr2170	COG0189	ligase activity
tlr2175	COG0419	ATPase involved in DNA repair
tlr2176	COG2304	oxidoreductase activity
tlr2184	COG0330	HflC and HflK could
tlr2187	COG0047	phosphoribosylformylglycinamidine synthase activity
tlr2188	COG2095	MarC family integral membrane protein
tlr2189	COG0741	lytic transglycosylase activity
tlr2189	COG0791	NLP P60 protein
tlr2196	COG1575	Belongs to the MenA family. Type 1 subfamily
tlr2203	COG0745	RESPONSE REGULATOR receiver
tlr2206	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
tlr2209	COG3781	membrane
tlr2210	COG2217	Heavy metal translocating P-type atpase
tlr2216	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
tlr2225	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
tlr2234	COG1381	Involved in DNA repair and RecF pathway recombination
tlr2236	COG2208	phosphoserine phosphatase activity
tlr2240	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
tlr2242	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
tlr2243	COG0631	protein serine/threonine phosphatase activity
tlr2245	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
tlr2256	COG0482	sulfurtransferase activity
tlr2259	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
tlr2260	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
tlr2261	COG0450	alkyl hydroperoxide reductase
tlr2263	COG0628	permease
tlr2269	COG0589	response to stress
tlr2276	COG0523	cobalamin synthesis protein
tlr2283	COG1217	gtp-binding protein TYPA
tlr2286	COG3118	belongs to the thioredoxin family
tlr2287	COG4399	Belongs to the UPF0754 family
tlr2289	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
tlr2290	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
tlr2305	COG4279	zinc finger
tlr2309	COG1657	PFAM Prenyltransferase squalene oxidase
tlr2312	COG0529	Catalyzes the synthesis of activated sulfate
tlr2317	COG1216	Glycosyl transferase, family 2
tlr2318	COG1442	glycosyl transferase family 8
tlr2318	COG1216	Glycosyl transferase, family 2
tlr2323	COG2197	response regulator
tlr2324	COG3659	wide pore channel activity
tlr2325	COG0793	Belongs to the peptidase S41A family
tlr2326	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
tlr2330	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
tlr2337	COG2252	PERMEase
tlr2338	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
tlr2340	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
tlr2354	COG1316	TRANSCRIPTIONal
tlr2355	COG1940	carbohydrate kinase activity
tlr2358	COG0463	Glycosyl transferase, family 2
tlr2368	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
tlr2368	COG2022	thiamine diphosphate biosynthetic process
tlr2377	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
tlr2384	COG1836	PFAM Integral membrane protein DUF92
tlr2389	COG0438	transferase activity, transferring glycosyl groups
tlr2393	COG0372	Belongs to the citrate synthase family
tlr2394	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
tlr2413	COG0359	binds to the 23S rRNA
tlr2414	COG1372	Participates in initiation and elongation during chromosome replication
tlr2414	COG0305	Participates in initiation and elongation during chromosome replication
tlr2414	COG0305	Participates in initiation and elongation during chromosome replication
tlr2414	COG1372	Participates in initiation and elongation during chromosome replication
tlr2415	COG4572	Cation transport regulator
tlr2419	COG0489	protein tyrosine kinase activity
tlr2420	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
tlr2423	COG0745	RESPONSE REGULATOR receiver
tlr2426	COG2205	protein histidine kinase activity
tlr2432	COG0515	serine threonine protein kinase
tlr2436	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
tlr2443	COG1799	cell septum assembly
tlr2462	COG0227	Belongs to the bacterial ribosomal protein bL28 family
tlr2465	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
tlr2472	COG1193	negative regulation of DNA recombination
tlr2473	COG0017	Asparaginyl-tRNA synthetase
tsl0023	COG2832	Protein of unknown function (DUF454)
tsl0038	COG0828	Belongs to the bacterial ribosomal protein bS21 family
tsl0040	COG0228	four-way junction DNA binding
tsl0166	COG0211	Belongs to the bacterial ribosomal protein bL27 family
tsl0602	COG0230	Belongs to the bacterial ribosomal protein bL34 family
tsl0875	COG0271	Belongs to the BolA IbaG family
tsl1009	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
tsl1013	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
tsl1188	COG0268	Binds directly to 16S ribosomal RNA
tsl1293	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
tsl1361	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
tsl1385	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
tsl1524	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
tsl1825	COG2154	pterin-4-alpha-carbinolamine dehydratase
tsl1872	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
tsl1889	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
tsl2094	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
tsl2159	COG0291	Belongs to the bacterial ribosomal protein bL35 family
tsl2208	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
tsl2255	COG0724	RNA recognition motif
tsl2331	COG2052	Domain of unknown function (DUF370)
tsl2468	COG3536	Protein conserved in bacteria
tsr0085	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
tsr0089	COG0255	Belongs to the universal ribosomal protein uL29 family
tsr0090	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
tsr0101	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
tsr0102	COG0257	Belongs to the bacterial ribosomal protein bL36 family
tsr0110	COG0254	rRNA binding
tsr0427	COG1366	Belongs to the anti-sigma-factor antagonist family
tsr0446	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
tsr0564	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
tsr0688	COG1376	ErfK ybiS ycfS ynhG family protein
tsr0695	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
tsr0907	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
tsr0983	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
tsr1002	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
tsr1069	COG0765	amino acid transport
tsr1087	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
tsr1207	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
tsr1443	COG0724	RNA recognition motif
tsr1755	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
tsr1915	COG0333	Belongs to the bacterial ribosomal protein bL32 family
tsr1960	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
tsr1994	COG1872	DUF167
tsr2060	COG0267	Belongs to the bacterial ribosomal protein bL33 family
tsr2061	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
tsr2185	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL