locus-tag	class	description
D3A95_RS00030	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
D3A95_RS00035	COG1132	(ABC) transporter
D3A95_RS00040	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
D3A95_RS00045	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
D3A95_RS00050	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
D3A95_RS00060	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
D3A95_RS00060	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
D3A95_RS00070	COG0625	glutathione transferase activity
D3A95_RS00075	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
D3A95_RS00085	COG0508	dehydrogenase complex catalyzes the overall conversion of
D3A95_RS00085	COG0022	dehydrogenase e1 component
D3A95_RS00090	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
D3A95_RS00095	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
D3A95_RS00130	COG2205	protein histidine kinase activity
D3A95_RS00145	COG0735	belongs to the Fur family
D3A95_RS00155	COG0285	dihydrofolate synthase activity
D3A95_RS00165	COG0004	ammonium transporteR
D3A95_RS00170	COG0395	ABC-type sugar transport system, permease component
D3A95_RS00175	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
D3A95_RS00180	COG0459	protein refolding
D3A95_RS00185	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
D3A95_RS00190	COG0788	formyltetrahydrofolate deformylase activity
D3A95_RS00200	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
D3A95_RS00210	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
D3A95_RS00215	COG1012	belongs to the aldehyde dehydrogenase family
D3A95_RS00220	COG4178	(ABC) transporter
D3A95_RS00230	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
D3A95_RS00235	COG1454	alcohol dehydrogenase
D3A95_RS00235	COG1012	belongs to the aldehyde dehydrogenase family
D3A95_RS00240	COG0095	Lipoate-protein ligase
D3A95_RS00255	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
D3A95_RS00265	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
D3A95_RS00265	COG0140	phosphoribosyl-ATP diphosphatase activity
D3A95_RS00285	COG1131	(ABC) transporter
D3A95_RS00285	COG0842	Transport permease protein
D3A95_RS00285	COG1716	ATPase activity
D3A95_RS00290	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
D3A95_RS00290	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
D3A95_RS00295	COG0612	Peptidase, M16
D3A95_RS00300	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
D3A95_RS00330	COG0156	8-amino-7-oxononanoate synthase activity
D3A95_RS00335	COG0745	RESPONSE REGULATOR receiver
D3A95_RS00340	COG1716	ATPase activity
D3A95_RS00340	COG0842	Transport permease protein
D3A95_RS00340	COG1131	(ABC) transporter
D3A95_RS00345	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
D3A95_RS00350	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
D3A95_RS00360	COG1357	PFAM Pentapeptide repeats (8 copies)
D3A95_RS00360	COG0515	serine threonine protein kinase
D3A95_RS00380	COG0704	Plays a role in the regulation of phosphate uptake
D3A95_RS00415	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
D3A95_RS00440	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
D3A95_RS00445	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
D3A95_RS00450	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
D3A95_RS00460	COG1472	Belongs to the glycosyl hydrolase 3 family
D3A95_RS00470	COG2046	Belongs to the sulfate adenylyltransferase family
D3A95_RS00485	COG0438	transferase activity, transferring glycosyl groups
D3A95_RS00490	COG0745	RESPONSE REGULATOR receiver
D3A95_RS00525	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
D3A95_RS00535	COG1528	Iron-storage protein
D3A95_RS00540	COG0742	ribosomal rna small subunit methyltransferase
D3A95_RS00545	COG0667	Aldo Keto reductase
D3A95_RS00555	COG2099	Precorrin-6x reductase
D3A95_RS00560	COG0129	dihydroxy-acid dehydratase activity
D3A95_RS00580	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
D3A95_RS00600	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
D3A95_RS00605	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
D3A95_RS00620	COG0612	Peptidase, M16
D3A95_RS00625	COG1716	ATPase activity
D3A95_RS00625	COG5001	Diguanylate cyclase
D3A95_RS00630	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
D3A95_RS00645	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
D3A95_RS00700	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
D3A95_RS00705	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
D3A95_RS00710	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D3A95_RS00720	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
D3A95_RS00750	COG4991	sh3 domain protein
D3A95_RS00750	COG3064	Membrane
D3A95_RS00750	COG0515	serine threonine protein kinase
D3A95_RS00795	COG0426	domain, Protein
D3A95_RS00795	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
D3A95_RS00800	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
D3A95_RS00835	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
D3A95_RS00850	COG0363	glucosamine-6-phosphate deaminase activity
D3A95_RS00875	COG0740	serine-type endopeptidase activity
D3A95_RS00880	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
D3A95_RS00885	COG0765	amino acid transport
D3A95_RS00895	COG0484	heat shock protein binding
D3A95_RS00900	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
D3A95_RS00905	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
D3A95_RS00910	COG0434	BtpA family
D3A95_RS00915	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
D3A95_RS00930	COG0217	transcriptional regulatory protein
D3A95_RS00935	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
D3A95_RS00935	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
D3A95_RS00945	COG4948	Mandelate Racemase Muconate Lactonizing
D3A95_RS00955	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
D3A95_RS00965	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
D3A95_RS00965	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
D3A95_RS00970	COG0457	Tetratricopeptide repeat
D3A95_RS00970	COG0463	Glycosyl transferase, family 2
D3A95_RS00975	COG0812	UDP-N-acetylmuramate dehydrogenase activity
D3A95_RS00980	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
D3A95_RS01030	COG2119	membrane
D3A95_RS01045	COG2385	sporulation resulting in formation of a cellular spore
D3A95_RS01080	COG2247	cell wall binding repeat
D3A95_RS01080	COG0860	N-Acetylmuramoyl-L-alanine amidase
D3A95_RS01135	COG0339	signal peptide processing
D3A95_RS01140	COG0739	heme binding
D3A95_RS01140	COG0741	lytic transglycosylase activity
D3A95_RS01140	COG1196	nuclear chromosome segregation
D3A95_RS01145	COG0768	penicillin binding
D3A95_RS01155	COG0107	imidazoleglycerol-phosphate synthase activity
D3A95_RS01160	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
D3A95_RS01165	COG0084	hydrolase, TatD family'
D3A95_RS01170	COG0268	Binds directly to 16S ribosomal RNA
D3A95_RS01175	COG1691	(AIR) carboxylase
D3A95_RS01190	COG0635	Involved in the biosynthesis of porphyrin-containing compound
D3A95_RS01220	COG1131	(ABC) transporter
D3A95_RS01230	COG0512	Glutamine amidotransferase of anthranilate synthase
D3A95_RS01230	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
D3A95_RS01250	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
D3A95_RS01255	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
D3A95_RS01275	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
D3A95_RS01285	COG3266	domain, Protein
D3A95_RS01285	COG0515	serine threonine protein kinase
D3A95_RS01315	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
D3A95_RS01320	COG0765	amino acid transport
D3A95_RS01325	COG0450	alkyl hydroperoxide reductase
D3A95_RS01340	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
D3A95_RS01355	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
D3A95_RS01370	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
D3A95_RS01380	COG0724	RNA recognition motif
D3A95_RS01410	COG1063	alcohol dehydrogenase
D3A95_RS01425	COG1494	fructose-1,6-bisphosphatase
D3A95_RS01430	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
D3A95_RS01440	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
D3A95_RS01465	COG3631	Ketosteroid isomerase-related protein
D3A95_RS01480	COG2062	phosphohistidine phosphatase, SixA
D3A95_RS01495	COG0745	RESPONSE REGULATOR receiver
D3A95_RS01510	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
D3A95_RS01535	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
D3A95_RS01540	COG0671	phosphoesterase, PA-phosphatase related
D3A95_RS01550	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
D3A95_RS01565	COG2082	Precorrin-8x methylmutase
D3A95_RS01585	COG1959	2 iron, 2 sulfur cluster binding
D3A95_RS01595	COG0261	This protein binds to 23S rRNA in the presence of protein L20
D3A95_RS01600	COG0211	Belongs to the bacterial ribosomal protein bL27 family
D3A95_RS01620	COG3842	ATPase activity
D3A95_RS01630	COG3411	Ferredoxin
D3A95_RS01645	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
D3A95_RS01650	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
D3A95_RS01655	COG1049	propionate catabolic process, 2-methylcitrate cycle
D3A95_RS01660	COG1192	Involved in chromosome partitioning
D3A95_RS01665	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
D3A95_RS01675	COG1376	ErfK ybiS ycfS ynhG family protein
D3A95_RS01685	COG0408	coproporphyrinogen oxidase activity
D3A95_RS01690	COG1333	cytochrome c biogenesis protein
D3A95_RS01700	COG2217	Heavy metal translocating P-type atpase
D3A95_RS01750	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
D3A95_RS01755	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
D3A95_RS01760	COG0713	ATP synthesis coupled electron transport
D3A95_RS01765	COG0839	Belongs to the complex I subunit 6 family
D3A95_RS01770	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D3A95_RS01775	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
D3A95_RS01780	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
D3A95_RS01785	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
D3A95_RS01790	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
D3A95_RS01795	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
D3A95_RS01805	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
D3A95_RS01805	COG0072	phenylalanine-tRNA ligase activity
D3A95_RS01810	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
D3A95_RS01820	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
D3A95_RS01825	COG0148	phosphopyruvate hydratase activity
D3A95_RS01830	COG2217	Heavy metal translocating P-type atpase
D3A95_RS01835	COG1187	pseudouridine synthase activity
D3A95_RS01845	COG1132	(ABC) transporter
D3A95_RS01860	COG0557	exoribonuclease II activity
D3A95_RS01875	COG0518	GMP synthase (glutamine-hydrolyzing) activity
D3A95_RS01875	COG0519	Catalyzes the synthesis of GMP from XMP
D3A95_RS01890	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
D3A95_RS01895	COG1372	Participates in initiation and elongation during chromosome replication
D3A95_RS01895	COG0187	DNA topoisomerase II activity
D3A95_RS01905	COG1187	pseudouridine synthase activity
D3A95_RS01910	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D3A95_RS01920	COG1136	(ABC) transporter
D3A95_RS01920	COG0577	efflux transmembrane transporter activity
D3A95_RS01925	COG0085	RNA polymerase activity
D3A95_RS01930	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
D3A95_RS01935	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
D3A95_RS01940	COG0501	Belongs to the peptidase M48B family
D3A95_RS01970	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
D3A95_RS02015	COG0515	serine threonine protein kinase
D3A95_RS02020	COG1716	ATPase activity
D3A95_RS02025	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
D3A95_RS02030	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D3A95_RS02055	COG0523	cobalamin synthesis protein
D3A95_RS02060	COG3659	wide pore channel activity
D3A95_RS02065	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
D3A95_RS02065	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
D3A95_RS02075	COG1606	tRNA processing
D3A95_RS02085	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
D3A95_RS02095	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
D3A95_RS02105	COG0601	transmembrane transport
D3A95_RS02120	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
D3A95_RS02135	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
D3A95_RS02145	COG1716	ATPase activity
D3A95_RS02145	COG1131	(ABC) transporter
D3A95_RS02145	COG0842	Transport permease protein
D3A95_RS02165	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
D3A95_RS02175	COG0745	RESPONSE REGULATOR receiver
D3A95_RS02180	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D3A95_RS02190	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
D3A95_RS02200	COG2081	HI0933 family
D3A95_RS02205	COG0668	transmembrane transport
D3A95_RS02215	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
D3A95_RS02245	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
D3A95_RS02250	COG1252	NADH dehydrogenase
D3A95_RS02255	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
D3A95_RS02270	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
D3A95_RS02290	COG1357	PFAM Pentapeptide repeats (8 copies)
D3A95_RS02290	COG0515	serine threonine protein kinase
D3A95_RS02300	COG0515	serine threonine protein kinase
D3A95_RS02315	COG0287	Prephenate dehydrogenase
D3A95_RS02320	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
D3A95_RS02335	COG1122	ATPase activity
D3A95_RS02345	COG1930	Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import
D3A95_RS02350	COG0310	cobalt ion transport
D3A95_RS02355	COG1799	cell septum assembly
D3A95_RS02365	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
D3A95_RS02380	COG1473	amidohydrolase
D3A95_RS02395	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
D3A95_RS02395	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
D3A95_RS02405	COG2268	Band 7 protein
D3A95_RS02410	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
D3A95_RS02420	COG0384	phenazine biosynthesis protein PhzF
D3A95_RS02425	COG0105	UTP biosynthetic process
D3A95_RS02430	COG0861	Integral membrane protein TerC family
D3A95_RS02445	COG1122	ATPase activity
D3A95_RS02450	COG1429	ligase activity, forming nitrogen-metal bonds
D3A95_RS02460	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
D3A95_RS02465	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
D3A95_RS02470	COG4208	sulfate ABC transporter
D3A95_RS02475	COG0460	homoserine dehydrogenase
D3A95_RS02485	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
D3A95_RS02490	COG0484	heat shock protein binding
D3A95_RS02495	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
D3A95_RS02505	COG1842	Phage shock protein A
D3A95_RS02510	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
D3A95_RS02515	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
D3A95_RS02530	COG0446	pyridine nucleotide-disulphide oxidoreductase
D3A95_RS02535	COG0629	single-stranded DNA binding
D3A95_RS02550	COG4636	protein conserved in cyanobacteria
D3A95_RS02565	COG0730	response to heat
D3A95_RS02570	COG0492	ferredoxin-NADP+ reductase activity
D3A95_RS02580	COG1196	nuclear chromosome segregation
D3A95_RS02590	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
D3A95_RS02595	COG0800	Aldolase
D3A95_RS02615	COG2045	Belongs to the ComB family
D3A95_RS02620	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
D3A95_RS02625	COG0598	Magnesium transport protein CorA
D3A95_RS02640	COG0857	belongs to the CobB CobQ family
D3A95_RS02670	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
D3A95_RS02680	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
D3A95_RS02685	COG2894	cell division
D3A95_RS02690	COG0850	regulation of cytokinetic process
D3A95_RS02700	COG0515	serine threonine protein kinase
D3A95_RS02770	COG0180	Tryptophanyl-tRNA synthetase
D3A95_RS02780	COG1872	DUF167
D3A95_RS02815	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
D3A95_RS02825	COG0004	ammonium transporteR
D3A95_RS02830	COG0220	tRNA (guanine-N7-)-methyltransferase activity
D3A95_RS02840	COG1234	tRNA 3'-trailer cleavage
D3A95_RS02870	COG0420	3'-5' exonuclease activity
D3A95_RS02875	COG0033	Phosphoglucomutase
D3A95_RS02880	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
D3A95_RS02885	COG0750	zinc metalloprotease
D3A95_RS02890	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
D3A95_RS02905	COG0181	hydroxymethylbilane synthase activity
D3A95_RS02925	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D3A95_RS02960	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
D3A95_RS02965	COG0483	inositol monophosphate 1-phosphatase activity
D3A95_RS02975	COG5002	protein histidine kinase activity
D3A95_RS02980	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
D3A95_RS02995	COG0247	lactate metabolic process
D3A95_RS03000	COG0277	FAD linked oxidase domain protein
D3A95_RS03015	COG0815	Transfers the fatty acyl group on membrane lipoproteins
D3A95_RS03045	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D3A95_RS03050	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
D3A95_RS03070	COG0242	peptide deformylase activity
D3A95_RS03080	COG0509	glycine decarboxylation via glycine cleavage system
D3A95_RS03085	COG0559	Belongs to the binding-protein-dependent transport system permease family
D3A95_RS03090	COG0248	Ppx GppA phosphatase
D3A95_RS03100	COG0454	-acetyltransferase
D3A95_RS03105	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
D3A95_RS03110	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
D3A95_RS03120	COG0307	riboflavin synthase, alpha
D3A95_RS03125	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
D3A95_RS03130	COG0052	Belongs to the universal ribosomal protein uS2 family
D3A95_RS03135	COG1192	Involved in chromosome partitioning
D3A95_RS03145	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
D3A95_RS03165	COG1842	Phage shock protein A
D3A95_RS03170	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
D3A95_RS03180	COG4447	cellulose binding
D3A95_RS03185	COG1773	rubredoxin
D3A95_RS03190	COG1489	DNA binding
D3A95_RS03215	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
D3A95_RS03230	COG0357	Ribosomal RNA small subunit methyltransferase G
D3A95_RS03240	COG3659	wide pore channel activity
D3A95_RS03245	COG2003	Belongs to the UPF0758 family
D3A95_RS03250	COG2326	polyphosphate kinase activity
D3A95_RS03260	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
D3A95_RS03270	COG1178	ABC-type Fe3 transport system permease component
D3A95_RS03275	COG0157	Belongs to the NadC ModD family
D3A95_RS03280	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
D3A95_RS03290	COG1492	cobalamin metabolic process
D3A95_RS03300	COG0588	phosphoglycerate mutase activity
D3A95_RS03305	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
D3A95_RS03315	COG5002	protein histidine kinase activity
D3A95_RS03320	COG0745	RESPONSE REGULATOR receiver
D3A95_RS03325	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
D3A95_RS03330	COG3596	GTP binding
D3A95_RS03335	COG0799	negative regulation of ribosome biogenesis
D3A95_RS03340	COG0318	PFAM AMP-dependent synthetase and ligase
D3A95_RS03345	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
D3A95_RS03350	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
D3A95_RS03360	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
D3A95_RS03365	COG1799	cell septum assembly
D3A95_RS03370	COG5002	protein histidine kinase activity
D3A95_RS03375	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
D3A95_RS03390	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
D3A95_RS03395	COG3706	GGDEF domain
D3A95_RS03410	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
D3A95_RS03415	COG0583	DNA-binding transcription factor activity
D3A95_RS03420	COG0515	serine threonine protein kinase
D3A95_RS03420	COG1357	PFAM Pentapeptide repeats (8 copies)
D3A95_RS03430	COG0504	CTP synthase activity
D3A95_RS03445	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
D3A95_RS03450	COG0697	spore germination
D3A95_RS03460	COG0442	prolyl-tRNA aminoacylation
D3A95_RS03475	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
D3A95_RS03485	COG0058	SHG alpha-glucan phosphorylase activity
D3A95_RS03490	COG2223	nitrite transmembrane transporter activity
D3A95_RS03495	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
D3A95_RS03510	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
D3A95_RS03525	COG0484	heat shock protein binding
D3A95_RS03530	COG0443	Heat shock 70 kDa protein
D3A95_RS03540	COG1666	GTP binding
D3A95_RS03575	COG0514	ATP-dependent DNA helicase (RecQ)
D3A95_RS03585	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
D3A95_RS03610	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
D3A95_RS03615	COG3956	TIGRFAM MazG family protein
D3A95_RS03620	COG0747	negative chemotaxis
D3A95_RS03630	COG3118	belongs to the thioredoxin family
D3A95_RS03645	COG0668	transmembrane transport
D3A95_RS03650	COG0678	peroxiredoxin activity
D3A95_RS03650	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
D3A95_RS03655	COG2217	Heavy metal translocating P-type atpase
D3A95_RS03665	COG1899	peptidyl-lysine modification to peptidyl-hypusine
D3A95_RS03670	COG1121	(ABC) transporter
D3A95_RS03680	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
D3A95_RS03695	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
D3A95_RS03700	COG0717	Belongs to the dCTP deaminase family
D3A95_RS03710	COG0018	arginyl-trna synthetase
D3A95_RS03730	COG3264	Mechanosensitive ion channel
D3A95_RS03730	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
D3A95_RS03740	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
D3A95_RS03745	COG0321	lipoyl(octanoyl) transferase activity
D3A95_RS03750	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
D3A95_RS03775	COG0772	Belongs to the SEDS family
D3A95_RS03780	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
D3A95_RS03805	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
D3A95_RS03810	COG0416	fatty acid biosynthetic process
D3A95_RS03815	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
D3A95_RS03840	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
D3A95_RS03845	COG1045	serine acetyltransferase
D3A95_RS03875	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
D3A95_RS03880	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
D3A95_RS03895	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
D3A95_RS03925	COG0316	Belongs to the HesB IscA family
D3A95_RS03930	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
D3A95_RS03935	COG2006	4fe-4S ferredoxin, iron-sulfur binding domain protein
D3A95_RS03955	COG0071	Belongs to the small heat shock protein (HSP20) family
D3A95_RS03960	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
D3A95_RS03965	COG0271	Belongs to the BolA IbaG family
D3A95_RS03970	COG5002	protein histidine kinase activity
D3A95_RS03970	COG2205	protein histidine kinase activity
D3A95_RS03970	COG0784	Response regulator, receiver
D3A95_RS03980	COG1160	GTP binding
D3A95_RS03995	COG0440	acetolactate synthase activity
D3A95_RS04005	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
D3A95_RS04020	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
D3A95_RS04030	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
D3A95_RS04045	COG1116	anion transmembrane transporter activity
D3A95_RS04075	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
D3A95_RS04080	COG1108	ABC-type Mn2 Zn2 transport systems permease components
D3A95_RS04085	COG1836	PFAM Integral membrane protein DUF92
D3A95_RS04090	COG0463	Glycosyl transferase, family 2
D3A95_RS04095	COG3385	transposase activity
D3A95_RS04110	COG1216	Glycosyl transferase, family 2
D3A95_RS04120	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
D3A95_RS04125	COG1882	Formate acetyltransferase
D3A95_RS04140	COG1162	GTPase activity
D3A95_RS04155	COG1253	flavin adenine dinucleotide binding
D3A95_RS04175	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
D3A95_RS04180	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
D3A95_RS04185	COG0831	urea catabolic process
D3A95_RS04190	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
D3A95_RS04195	COG2048	Heterodisulfide reductase, subunit B
D3A95_RS04200	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
D3A95_RS04215	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
D3A95_RS04220	COG1063	alcohol dehydrogenase
D3A95_RS04225	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
D3A95_RS04240	COG0149	triose-phosphate isomerase activity
D3A95_RS04250	COG1192	Involved in chromosome partitioning
D3A95_RS04255	COG1132	(ABC) transporter
D3A95_RS04300	COG0805	protein transport
D3A95_RS04305	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
D3A95_RS04310	COG1091	dTDP-4-dehydrorhamnose reductase activity
D3A95_RS04315	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
D3A95_RS04335	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
D3A95_RS04340	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
D3A95_RS04345	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
D3A95_RS04345	COG4451	ribulose bisphosphate carboxylase, small
D3A95_RS04355	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
D3A95_RS04375	COG1077	Cell shape determining protein MreB Mrl
D3A95_RS04390	COG0741	lytic transglycosylase activity
D3A95_RS04400	COG1028	Short-chain dehydrogenase reductase Sdr
D3A95_RS04410	COG0436	Aminotransferase
D3A95_RS04415	COG0552	protein localization to endoplasmic reticulum
D3A95_RS04420	COG1218	3'(2'),5'-bisphosphate nucleotidase
D3A95_RS04430	COG5002	protein histidine kinase activity
D3A95_RS04435	COG3706	GGDEF domain
D3A95_RS04435	COG5001	Diguanylate cyclase
D3A95_RS04435	COG2203	Gaf domain
D3A95_RS04435	COG4251	negative regulation of phosphorylation
D3A95_RS04445	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
D3A95_RS04465	COG0596	Alpha beta hydrolase
D3A95_RS04480	COG1234	tRNA 3'-trailer cleavage
D3A95_RS04480	COG1555	photosystem II stabilization
D3A95_RS04490	COG1104	cysteine desulfurase activity
D3A95_RS04515	COG2239	Acts as a magnesium transporter
D3A95_RS04520	COG1285	pathogenesis
D3A95_RS04525	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
D3A95_RS04535	COG2189	Belongs to the N(4) N(6)-methyltransferase family
D3A95_RS04540	COG0189	ligase activity
D3A95_RS04545	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
D3A95_RS04555	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D3A95_RS04560	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
D3A95_RS04585	COG2205	protein histidine kinase activity
D3A95_RS04590	COG0237	dephospho-CoA kinase activity
D3A95_RS04605	COG0602	queuosine metabolic process
D3A95_RS04620	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
D3A95_RS04625	COG1840	ABC-type Fe3 transport system, periplasmic component
D3A95_RS04640	COG0469	pyruvate kinase activity
D3A95_RS04650	COG0470	DNA polymerase III
D3A95_RS04655	COG0617	tRNA 3'-terminal CCA addition
D3A95_RS04655	COG0517	IMP dehydrogenase activity
D3A95_RS04655	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
D3A95_RS04670	COG1181	Belongs to the D-alanine--D-alanine ligase family
D3A95_RS04680	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
D3A95_RS04695	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
D3A95_RS04700	COG0312	modulator of DNA gyrase
D3A95_RS04705	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
D3A95_RS04710	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
D3A95_RS04720	COG0632	four-way junction helicase activity
D3A95_RS04740	COG0445	tRNA wobble uridine modification
D3A95_RS04745	COG0829	nickel cation binding
D3A95_RS04755	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
D3A95_RS04755	COG0475	glutathione-regulated potassium exporter activity
D3A95_RS04760	COG3429	Glucose-6-phosphate dehydrogenase subunit
D3A95_RS04760	COG3409	Peptidoglycan-binding domain 1 protein
D3A95_RS04765	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
D3A95_RS04770	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
D3A95_RS04810	COG4251	negative regulation of phosphorylation
D3A95_RS04830	COG1132	(ABC) transporter
D3A95_RS04845	COG0693	protein deglycase activity
D3A95_RS04855	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
D3A95_RS04870	COG1086	Polysaccharide biosynthesis protein
D3A95_RS04885	COG0297	glycogen (starch) synthase activity
D3A95_RS04890	COG0123	including yeast histone deacetylase and acetoin utilization protein
D3A95_RS04900	COG1083	cytidylyl-transferase
D3A95_RS04905	COG3980	spore coat polysaccharide biosynthesis protein
D3A95_RS04915	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
D3A95_RS04920	COG1598	PFAM Uncharacterised protein family UPF0150
D3A95_RS04940	COG2089	acid synthase
D3A95_RS04955	COG0643	Histidine kinase
D3A95_RS04955	COG2198	Histidine kinase
D3A95_RS04955	COG0784	Response regulator, receiver
D3A95_RS04960	COG2203	Gaf domain
D3A95_RS04960	COG0840	transmembrane signaling receptor activity
D3A95_RS04975	COG0784	Response regulator, receiver
D3A95_RS04985	COG3659	wide pore channel activity
D3A95_RS05000	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
D3A95_RS05005	COG1028	Short-chain dehydrogenase reductase Sdr
D3A95_RS05010	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
D3A95_RS05015	COG1132	(ABC) transporter
D3A95_RS05020	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
D3A95_RS05025	COG0167	dihydroorotate dehydrogenase activity
D3A95_RS05035	COG1122	ATPase activity
D3A95_RS05040	COG0438	transferase activity, transferring glycosyl groups
D3A95_RS05055	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
D3A95_RS05055	COG0574	Belongs to the PEP-utilizing enzyme family
D3A95_RS05060	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
D3A95_RS05070	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
D3A95_RS05075	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
D3A95_RS05080	COG4243	Vitamin k epoxide reductase
D3A95_RS05085	COG0745	RESPONSE REGULATOR receiver
D3A95_RS05095	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
D3A95_RS05105	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
D3A95_RS05135	COG1530	ribonuclease E activity
D3A95_RS05140	COG2066	Belongs to the glutaminase family
D3A95_RS05150	COG0706	membrane insertase activity
D3A95_RS05155	COG0594	ribonuclease P activity
D3A95_RS05160	COG0230	Belongs to the bacterial ribosomal protein bL34 family
D3A95_RS05165	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
D3A95_RS05170	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
D3A95_RS05195	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
D3A95_RS05200	COG0701	Predicted permease
D3A95_RS05205	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
D3A95_RS05210	COG0783	Belongs to the Dps family
D3A95_RS05220	COG2133	pyrroloquinoline quinone binding
D3A95_RS05230	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
D3A95_RS05240	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
D3A95_RS05245	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
D3A95_RS05255	COG0581	inorganic phosphate transmembrane transporter activity
D3A95_RS05260	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
D3A95_RS05265	COG0154	amidase activity
D3A95_RS05275	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
D3A95_RS05295	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
D3A95_RS05315	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D3A95_RS05330	COG1215	transferase activity, transferring glycosyl groups
D3A95_RS05340	COG0640	Transcriptional regulator
D3A95_RS05360	COG2203	Gaf domain
D3A95_RS05360	COG0840	transmembrane signaling receptor activity
D3A95_RS05400	COG0559	Belongs to the binding-protein-dependent transport system permease family
D3A95_RS05410	COG0537	adenosine 5'-monophosphoramidase activity
D3A95_RS05415	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
D3A95_RS05430	COG3706	GGDEF domain
D3A95_RS05440	COG0165	Argininosuccinate lyase
D3A95_RS05445	COG5398	heme oxygenase
D3A95_RS05465	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
D3A95_RS05480	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D3A95_RS05515	COG4581	dead DEAH box helicase
D3A95_RS05520	COG0643	Histidine kinase
D3A95_RS05520	COG0784	Response regulator, receiver
D3A95_RS05520	COG2198	Histidine kinase
D3A95_RS05520	COG0643	Histidine kinase
D3A95_RS05520	COG0784	Response regulator, receiver
D3A95_RS05520	COG2198	Histidine kinase
D3A95_RS05525	COG0840	transmembrane signaling receptor activity
D3A95_RS05550	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
D3A95_RS05565	COG0429	hydrolase of the alpha beta-hydrolase fold
D3A95_RS05575	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
D3A95_RS05585	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
D3A95_RS05600	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
D3A95_RS05605	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
D3A95_RS05615	COG0259	pyridoxamine-phosphate oxidase activity
D3A95_RS05620	COG0832	Belongs to the urease beta subunit family
D3A95_RS05635	COG0438	transferase activity, transferring glycosyl groups
D3A95_RS05640	COG2264	protein methyltransferase activity
D3A95_RS05645	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
D3A95_RS05675	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
D3A95_RS05680	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
D3A95_RS05695	COG1595	DNA-templated transcription, initiation
D3A95_RS05700	COG0811	peptide transport
D3A95_RS05710	COG0457	Tetratricopeptide repeat
D3A95_RS05710	COG0463	Glycosyl transferase, family 2
D3A95_RS05720	COG1074	ATP-dependent DNA helicase activity
D3A95_RS05730	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
D3A95_RS05735	COG0542	response to heat
D3A95_RS05750	COG0481	GTPase activity
D3A95_RS05760	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
D3A95_RS05780	COG0328	RNA-DNA hybrid ribonuclease activity
D3A95_RS05785	COG0222	ribosome binding
D3A95_RS05790	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
D3A95_RS05795	COG0081	regulation of translation
D3A95_RS05800	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
D3A95_RS05805	COG0250	Participates in transcription elongation, termination and antitermination
D3A95_RS05830	COG0675	Transposase, IS605 OrfB family
D3A95_RS05845	COG2217	Heavy metal translocating P-type atpase
D3A95_RS05870	COG0333	Belongs to the bacterial ribosomal protein bL32 family
D3A95_RS05875	COG0572	uridine kinase
D3A95_RS05885	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
D3A95_RS05890	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
D3A95_RS05895	COG0716	FMN binding
D3A95_RS05905	COG0719	Fe-S assembly protein
D3A95_RS05910	COG0396	ATPase activity
D3A95_RS05920	COG3693	PFAM glycoside hydrolase, family 10
D3A95_RS05925	COG1131	(ABC) transporter
D3A95_RS05935	COG0497	DNA recombination
D3A95_RS05945	COG0124	histidyl-tRNA synthetase
D3A95_RS05965	COG1612	heme a metabolic process
D3A95_RS05970	COG0109	protoheme IX farnesyltransferase activity
D3A95_RS05980	COG4221	oxidoreductase activity
D3A95_RS05990	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
D3A95_RS06000	COG1754	DNA topoisomerase type I activity
D3A95_RS06000	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
D3A95_RS06015	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
D3A95_RS06025	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
D3A95_RS06030	COG0557	exoribonuclease II activity
D3A95_RS06035	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
D3A95_RS06040	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
D3A95_RS06045	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
D3A95_RS06060	COG3906	Belongs to the UPF0473 family
D3A95_RS06065	COG1982	Orn Lys Arg decarboxylase major
D3A95_RS06090	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
D3A95_RS06100	COG0675	Transposase, IS605 OrfB family
D3A95_RS06115	COG0473	3-isopropylmalate dehydrogenase activity
D3A95_RS06130	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
D3A95_RS06145	COG0515	serine threonine protein kinase
D3A95_RS06160	COG0438	transferase activity, transferring glycosyl groups
D3A95_RS06165	COG0438	transferase activity, transferring glycosyl groups
D3A95_RS06175	COG0174	glutamine synthetase
D3A95_RS06180	COG0012	GTP binding
D3A95_RS06185	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
D3A95_RS06190	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
D3A95_RS06200	COG0772	Belongs to the SEDS family
D3A95_RS06220	COG1218	3'(2'),5'-bisphosphate nucleotidase
D3A95_RS06240	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D3A95_RS06250	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
D3A95_RS06255	COG1543	Belongs to the glycosyl hydrolase 57 family
D3A95_RS06260	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
D3A95_RS06270	COG2308	Evidence 4 Homologs of previously reported genes of
D3A95_RS06275	COG0525	valine-tRNA ligase activity
D3A95_RS06280	COG0518	GMP synthase (glutamine-hydrolyzing) activity
D3A95_RS06280	COG0519	Catalyzes the synthesis of GMP from XMP
D3A95_RS06285	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
D3A95_RS06295	COG0739	heme binding
D3A95_RS06300	COG0237	dephospho-CoA kinase activity
D3A95_RS06305	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
D3A95_RS06310	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
D3A95_RS06315	COG1413	lyase activity
D3A95_RS06320	COG1413	lyase activity
D3A95_RS06325	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
D3A95_RS06330	COG0237	dephospho-CoA kinase activity
D3A95_RS06345	COG1573	uracil-dna glycosylase
D3A95_RS06360	COG2226	methyltransferase
D3A95_RS06370	COG0391	Required for morphogenesis under gluconeogenic growth conditions
D3A95_RS06380	COG0354	folic acid binding
D3A95_RS06385	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
D3A95_RS06390	COG0352	thiamine-phosphate diphosphorylase activity
D3A95_RS06415	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
D3A95_RS06430	COG0779	Required for maturation of 30S ribosomal subunits
D3A95_RS06435	COG0195	Participates in both transcription termination and antitermination
D3A95_RS06455	COG0681	Belongs to the peptidase S26 family
D3A95_RS06490	COG0569	domain protein
D3A95_RS06505	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
D3A95_RS06515	COG1012	belongs to the aldehyde dehydrogenase family
D3A95_RS06525	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
D3A95_RS06525	COG0438	transferase activity, transferring glycosyl groups
D3A95_RS06540	COG0431	NADPH-dependent FMN reductase
D3A95_RS06545	COG0113	porphobilinogen synthase activity
D3A95_RS06555	COG0024	Methionine aminopeptidase
D3A95_RS06560	COG0415	Belongs to the DNA photolyase family
D3A95_RS06570	COG1366	Belongs to the anti-sigma-factor antagonist family
D3A95_RS06575	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
D3A95_RS06600	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
D3A95_RS06605	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
D3A95_RS06610	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
D3A95_RS06615	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
D3A95_RS06620	COG5002	protein histidine kinase activity
D3A95_RS06630	COG0159	tryptophan synthase activity
D3A95_RS06635	COG0772	Belongs to the SEDS family
D3A95_RS06645	COG4172	Belongs to the ABC transporter superfamily
D3A95_RS06660	COG0515	serine threonine protein kinase
D3A95_RS06665	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
D3A95_RS06680	COG5002	protein histidine kinase activity
D3A95_RS06685	COG0475	glutathione-regulated potassium exporter activity
D3A95_RS06690	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
D3A95_RS06695	COG0802	atpase or kinase
D3A95_RS06700	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
D3A95_RS06720	COG2884	Cell division ATP-binding protein ftsE
D3A95_RS06755	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
D3A95_RS06760	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
D3A95_RS06770	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
D3A95_RS06775	COG0316	Belongs to the HesB IscA family
D3A95_RS06780	COG1090	epimerase
D3A95_RS06790	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
D3A95_RS06805	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
D3A95_RS06820	COG0077	Prephenate dehydratase
D3A95_RS06825	COG0686	Belongs to the AlaDH PNT family
D3A95_RS06830	COG0575	Belongs to the CDS family
D3A95_RS06845	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
D3A95_RS06860	COG0411	ABC transporter
D3A95_RS06870	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
D3A95_RS06880	COG1725	Transcriptional regulator
D3A95_RS06885	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
D3A95_RS06890	COG0483	inositol monophosphate 1-phosphatase activity
D3A95_RS06910	COG0405	Gamma-glutamyltransferase
D3A95_RS06915	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
D3A95_RS06920	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D3A95_RS06930	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
D3A95_RS06935	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
D3A95_RS06940	COG1546	Belongs to the CinA family
D3A95_RS06940	COG1058	Belongs to the CinA family
D3A95_RS06955	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
D3A95_RS07015	COG0659	secondary active sulfate transmembrane transporter activity
D3A95_RS07020	COG2094	Belongs to the DNA glycosylase MPG family
D3A95_RS07030	COG0484	heat shock protein binding
D3A95_RS07035	COG0443	Heat shock 70 kDa protein
D3A95_RS07045	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
D3A95_RS07045	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
D3A95_RS07055	COG0739	heme binding
D3A95_RS07060	COG1587	Uroporphyrinogen-III synthase
D3A95_RS07070	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
D3A95_RS07075	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
D3A95_RS07080	COG0291	Belongs to the bacterial ribosomal protein bL35 family
D3A95_RS07090	COG2302	S4 RNA-binding domain
D3A95_RS07105	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
D3A95_RS07110	COG0573	inorganic phosphate transmembrane transporter activity
D3A95_RS07115	COG0581	inorganic phosphate transmembrane transporter activity
D3A95_RS07120	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
D3A95_RS07150	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
D3A95_RS07150	COG0189	ligase activity
D3A95_RS07170	COG0419	ATPase involved in DNA repair
D3A95_RS07175	COG2304	oxidoreductase activity
D3A95_RS07185	COG4221	oxidoreductase activity
D3A95_RS07200	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
D3A95_RS07200	COG0546	phosphoglycolate phosphatase activity
D3A95_RS07210	COG2205	protein histidine kinase activity
D3A95_RS07230	COG0330	HflC and HflK could
D3A95_RS07235	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
D3A95_RS07245	COG0047	phosphoribosylformylglycinamidine synthase activity
D3A95_RS07265	COG0791	NLP P60 protein
D3A95_RS07265	COG0741	lytic transglycosylase activity
D3A95_RS07270	COG0516	GMP reductase activity
D3A95_RS07280	COG0751	glycine-tRNA ligase activity
D3A95_RS07285	COG1185	polyribonucleotide nucleotidyltransferase activity
D3A95_RS07300	COG1575	Belongs to the MenA family. Type 1 subfamily
D3A95_RS07310	COG0456	acetyltransferase
D3A95_RS07315	COG0778	Nitroreductase
D3A95_RS07320	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
D3A95_RS07325	COG0745	RESPONSE REGULATOR receiver
D3A95_RS07330	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
D3A95_RS07335	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
D3A95_RS07340	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
D3A95_RS07355	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
D3A95_RS07360	COG3781	membrane
D3A95_RS07370	COG0582	viral genome integration into host DNA
D3A95_RS07385	COG0443	Heat shock 70 kDa protein
D3A95_RS07390	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
D3A95_RS07405	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
D3A95_RS07420	COG2815	serine threonine protein kinase
D3A95_RS07420	COG0515	serine threonine protein kinase
D3A95_RS07430	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
D3A95_RS07435	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
D3A95_RS07445	COG1381	Involved in DNA repair and RecF pathway recombination
D3A95_RS07455	COG2208	phosphoserine phosphatase activity
D3A95_RS07465	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
D3A95_RS07475	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
D3A95_RS07480	COG0631	protein serine/threonine phosphatase activity
D3A95_RS07490	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
D3A95_RS07500	COG0793	Belongs to the peptidase S41A family
D3A95_RS07550	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
D3A95_RS07565	COG2255	four-way junction helicase activity
D3A95_RS07570	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
D3A95_RS07575	COG0724	RNA recognition motif
D3A95_RS07580	COG0482	sulfurtransferase activity
D3A95_RS07595	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
D3A95_RS07600	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
D3A95_RS07605	COG0450	alkyl hydroperoxide reductase
D3A95_RS07615	COG0628	permease
D3A95_RS07635	COG0006	proline dipeptidase activity
D3A95_RS07640	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
D3A95_RS07645	COG0776	regulation of translation
D3A95_RS07650	COG0126	phosphoglycerate kinase activity
D3A95_RS07655	COG0589	response to stress
D3A95_RS07675	COG0135	phosphoribosylanthranilate isomerase activity
D3A95_RS07690	COG0469	pyruvate kinase activity
D3A95_RS07695	COG0523	cobalamin synthesis protein
D3A95_RS07765	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
D3A95_RS07770	COG3118	belongs to the thioredoxin family
D3A95_RS07775	COG4399	Belongs to the UPF0754 family
D3A95_RS07785	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
D3A95_RS07790	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
D3A95_RS07795	COG5505	Protein of unknown function (DUF819)
D3A95_RS07810	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
D3A95_RS07820	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
D3A95_RS07865	COG4279	zinc finger
D3A95_RS07870	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
D3A95_RS07890	COG1657	PFAM Prenyltransferase squalene oxidase
D3A95_RS07895	COG4783	chaperone-mediated protein folding
D3A95_RS07915	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
D3A95_RS07920	COG0556	nucleotide-excision repair
D3A95_RS07930	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
D3A95_RS07940	COG0583	DNA-binding transcription factor activity
D3A95_RS07950	COG0170	dolichyl monophosphate biosynthetic process
D3A95_RS07955	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
D3A95_RS07970	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
D3A95_RS07975	COG0436	Aminotransferase
D3A95_RS08005	COG0495	leucyl-tRNA aminoacylation
D3A95_RS08010	COG0489	protein tyrosine kinase activity
D3A95_RS08025	COG0438	transferase activity, transferring glycosyl groups
D3A95_RS08030	COG0438	transferase activity, transferring glycosyl groups
D3A95_RS08045	COG1216	Glycosyl transferase, family 2
D3A95_RS08065	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D3A95_RS08090	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
D3A95_RS08100	COG3118	belongs to the thioredoxin family
D3A95_RS08130	COG0714	Associated with various cellular activities
D3A95_RS08140	COG0058	SHG alpha-glucan phosphorylase activity
D3A95_RS08150	COG3932	Exopolysaccharide synthesis, ExoD
D3A95_RS08170	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
D3A95_RS08175	COG0539	negative regulation of cytoplasmic translation
D3A95_RS08180	COG1970	mechanosensitive ion channel activity
D3A95_RS08215	COG3158	transport of potassium into the cell
D3A95_RS08220	COG0436	Aminotransferase
D3A95_RS08225	COG0371	Dehydrogenase
D3A95_RS08235	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D3A95_RS08235	COG2022	thiamine diphosphate biosynthetic process
D3A95_RS08245	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
D3A95_RS08250	COG0587	DNA-directed DNA polymerase activity
D3A95_RS08270	COG0267	Belongs to the bacterial ribosomal protein bL33 family
D3A95_RS08275	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
D3A95_RS08280	COG3443	Belongs to the bacterial solute-binding protein 9 family
D3A95_RS08280	COG0803	Belongs to the bacterial solute-binding protein 9 family
D3A95_RS08285	COG1121	(ABC) transporter
D3A95_RS08300	COG0596	Alpha beta hydrolase
D3A95_RS08310	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
D3A95_RS08315	COG0587	DNA-directed DNA polymerase activity
D3A95_RS08340	COG0275	rRNA processing
D3A95_RS08350	COG0768	penicillin binding
D3A95_RS08365	COG0582	viral genome integration into host DNA
D3A95_RS08395	COG3385	transposase activity
D3A95_RS08400	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
D3A95_RS08410	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
D3A95_RS08435	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
D3A95_RS08440	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
D3A95_RS08455	COG0824	Thioesterase
D3A95_RS08465	COG0719	Fe-S assembly protein
D3A95_RS08485	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
D3A95_RS08490	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
D3A95_RS08500	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D3A95_RS08510	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
D3A95_RS08515	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
D3A95_RS08520	COG1108	ABC-type Mn2 Zn2 transport systems permease components
D3A95_RS08525	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
D3A95_RS08530	COG1959	2 iron, 2 sulfur cluster binding
D3A95_RS08535	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
D3A95_RS08555	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
D3A95_RS08560	COG1834	amidinotransferase
D3A95_RS08565	COG0544	peptidyl-prolyl cis-trans isomerase activity
D3A95_RS08570	COG0740	serine-type endopeptidase activity
D3A95_RS08575	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
D3A95_RS08580	COG4221	oxidoreductase activity
D3A95_RS08595	COG2226	methyltransferase
D3A95_RS08600	COG0589	response to stress
D3A95_RS08615	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
D3A95_RS08620	COG2022	thiamine diphosphate biosynthetic process
D3A95_RS08620	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D3A95_RS08630	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
D3A95_RS08635	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
D3A95_RS08635	COG0237	dephospho-CoA kinase activity
D3A95_RS08640	COG0745	RESPONSE REGULATOR receiver
D3A95_RS08665	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
D3A95_RS08670	COG0463	Glycosyl transferase, family 2
D3A95_RS08680	COG0436	Aminotransferase
D3A95_RS08685	COG1940	carbohydrate kinase activity
D3A95_RS08690	COG1316	TRANSCRIPTIONal
D3A95_RS08695	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
D3A95_RS08705	COG5002	protein histidine kinase activity
D3A95_RS08710	COG0728	peptidoglycan biosynthetic process
D3A95_RS08715	COG0592	DNA-directed DNA polymerase activity
D3A95_RS08725	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
D3A95_RS08735	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
D3A95_RS08760	COG1376	ErfK ybiS ycfS ynhG family protein
D3A95_RS08770	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
D3A95_RS08780	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
D3A95_RS08785	COG2252	PERMEase
D3A95_RS08810	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
D3A95_RS08815	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
D3A95_RS08825	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
D3A95_RS08830	COG2052	Domain of unknown function (DUF370)
D3A95_RS08860	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
D3A95_RS08865	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
D3A95_RS08895	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
D3A95_RS08900	COG0793	Belongs to the peptidase S41A family
D3A95_RS08905	COG3659	wide pore channel activity
D3A95_RS08910	COG2197	response regulator
D3A95_RS08915	COG4636	protein conserved in cyanobacteria
D3A95_RS08940	COG0284	orotidine-5'-phosphate decarboxylase activity
D3A95_RS08955	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
D3A95_RS08965	COG2385	sporulation resulting in formation of a cellular spore
D3A95_RS08975	COG0233	cytoplasmic translational termination
D3A95_RS08980	COG0528	UMP kinase activity
D3A95_RS08990	COG0745	RESPONSE REGULATOR receiver
D3A95_RS09010	COG1192	Involved in chromosome partitioning
D3A95_RS09015	COG0542	response to heat
D3A95_RS09030	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
D3A95_RS09075	COG0227	Belongs to the bacterial ribosomal protein bL28 family
D3A95_RS09080	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
D3A95_RS09090	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
D3A95_RS09095	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
D3A95_RS09100	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
D3A95_RS09105	COG3536	Protein conserved in bacteria
D3A95_RS09110	COG5001	Diguanylate cyclase
D3A95_RS09130	COG1193	negative regulation of DNA recombination
D3A95_RS09135	COG0017	Asparaginyl-tRNA synthetase
D3A95_RS09140	COG0475	glutathione-regulated potassium exporter activity
D3A95_RS09140	COG0589	response to stress
D3A95_RS09145	COG0133	tryptophan synthase activity
D3A95_RS09165	COG0612	Peptidase, M16
D3A95_RS09175	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
D3A95_RS09180	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
D3A95_RS09185	COG0735	belongs to the Fur family
D3A95_RS09195	COG1619	proteins homologs of microcin C7 resistance protein MccF
D3A95_RS09200	COG0675	Transposase, IS605 OrfB family
D3A95_RS09215	COG1007	ATP synthesis coupled electron transport
D3A95_RS09220	COG0425	Belongs to the sulfur carrier protein TusA family
D3A95_RS09220	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
D3A95_RS09225	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
D3A95_RS09230	COG0318	PFAM AMP-dependent synthetase and ligase
D3A95_RS09230	COG0204	Acyl-transferase
D3A95_RS09235	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
D3A95_RS09240	COG0228	four-way junction DNA binding
D3A95_RS09250	COG0828	Belongs to the bacterial ribosomal protein bS21 family
D3A95_RS09255	COG1702	phosphate starvation-inducible protein PhoH
D3A95_RS09275	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
D3A95_RS09285	COG2205	protein histidine kinase activity
D3A95_RS09315	COG2832	Protein of unknown function (DUF454)
D3A95_RS09325	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
D3A95_RS09335	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
D3A95_RS09350	COG2211	Major facilitator Superfamily
D3A95_RS09355	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
D3A95_RS09360	COG2954	triphosphatase activity
D3A95_RS09365	COG1473	amidohydrolase
D3A95_RS09390	COG4956	integral membrane protein (PIN domain superfamily)
D3A95_RS09410	COG0804	urea catabolic process
D3A95_RS09420	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
D3A95_RS09440	COG0194	GDP metabolic process
D3A95_RS09445	COG0848	biopolymer transport protein
D3A95_RS09450	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
D3A95_RS09455	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
D3A95_RS09460	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
D3A95_RS09470	COG0420	3'-5' exonuclease activity
D3A95_RS09495	COG2022	thiamine diphosphate biosynthetic process
D3A95_RS09505	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
D3A95_RS09515	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
D3A95_RS09520	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
D3A95_RS09565	COG0628	permease
D3A95_RS09570	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
D3A95_RS09585	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
D3A95_RS09610	COG0343	queuine tRNA-ribosyltransferase activity
D3A95_RS09615	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
D3A95_RS09620	COG0088	Forms part of the polypeptide exit tunnel
D3A95_RS09625	COG0089	rRNA binding
D3A95_RS09630	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
D3A95_RS09635	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
D3A95_RS09640	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
D3A95_RS09645	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
D3A95_RS09650	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
D3A95_RS09655	COG0255	Belongs to the universal ribosomal protein uL29 family
D3A95_RS09660	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
D3A95_RS09665	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
D3A95_RS09670	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
D3A95_RS09675	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
D3A95_RS09680	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
D3A95_RS09685	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
D3A95_RS09690	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
D3A95_RS09695	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
D3A95_RS09700	COG0200	Binds to the 23S rRNA
D3A95_RS09705	COG0201	protein transport
D3A95_RS09710	COG0563	adenylate kinase activity
D3A95_RS09715	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
D3A95_RS09720	COG0257	Belongs to the bacterial ribosomal protein bL36 family
D3A95_RS09725	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
D3A95_RS09730	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
D3A95_RS09735	COG0202	RNA polymerase activity
D3A95_RS09740	COG0203	ribosomal protein L17
D3A95_RS09745	COG0101	tRNA pseudouridine synthase activity
D3A95_RS09750	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
D3A95_RS09755	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
D3A95_RS09760	COG0254	rRNA binding
D3A95_RS09785	COG4802	Ferredoxin thioredoxin reductase catalytic beta chain
D3A95_RS09795	COG1104	cysteine desulfurase activity
D3A95_RS09810	COG0484	heat shock protein binding
D3A95_RS09825	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
D3A95_RS09855	COG0066	3-isopropylmalate dehydratase activity
D3A95_RS09860	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
D3A95_RS09880	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
D3A95_RS09885	COG1518	maintenance of DNA repeat elements
D3A95_RS09885	COG1468	defense response to virus
D3A95_RS09890	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
D3A95_RS09900	COG1203	CRISPR-associated helicase, Cas3
D3A95_RS09910	COG1857	crispr-associated protein
D3A95_RS09940	COG5398	heme oxygenase
D3A95_RS09945	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
D3A95_RS09975	COG3150	esterase
D3A95_RS09980	COG2226	methyltransferase
D3A95_RS09985	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
D3A95_RS09985	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
D3A95_RS10005	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
D3A95_RS10010	COG0443	Heat shock 70 kDa protein
D3A95_RS10025	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
D3A95_RS10025	COG3264	Mechanosensitive ion channel
D3A95_RS10030	COG0792	nuclease activity
D3A95_RS10035	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
D3A95_RS10045	COG3977	Valine--pyruvate aminotransferase
D3A95_RS10050	COG0675	Transposase, IS605 OrfB family
D3A95_RS10060	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D3A95_RS10070	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
D3A95_RS10075	COG1385	rRNA (uridine-N3-)-methyltransferase activity
D3A95_RS10080	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
D3A95_RS10085	COG0049	tRNA binding
D3A95_RS10090	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
D3A95_RS10095	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
D3A95_RS10100	COG0051	transcription antitermination factor activity, RNA binding
D3A95_RS10110	COG0322	excinuclease ABC activity
D3A95_RS10120	COG0347	Belongs to the P(II) protein family
D3A95_RS10130	COG1742	UPF0060 membrane protein
D3A95_RS10135	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
D3A95_RS10140	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
D3A95_RS10145	COG3842	ATPase activity
D3A95_RS10150	COG0142	geranyltranstransferase activity
D3A95_RS10160	COG0740	serine-type endopeptidase activity
D3A95_RS10170	COG0019	diaminopimelate decarboxylase activity
D3A95_RS10180	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
D3A95_RS10185	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
D3A95_RS10190	COG0083	homoserine kinase activity
D3A95_RS10200	COG0489	protein tyrosine kinase activity
D3A95_RS10210	COG1136	(ABC) transporter
D3A95_RS10225	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
D3A95_RS10230	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
D3A95_RS10230	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
D3A95_RS10250	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
D3A95_RS10285	COG4372	Transposase
D3A95_RS10295	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
D3A95_RS10315	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
D3A95_RS10320	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
D3A95_RS10325	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
D3A95_RS10330	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
D3A95_RS10345	COG1215	transferase activity, transferring glycosyl groups
D3A95_RS10350	COG1215	transferase activity, transferring glycosyl groups
D3A95_RS10360	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
D3A95_RS10370	COG4636	protein conserved in cyanobacteria
D3A95_RS10375	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
D3A95_RS10380	COG2843	Capsule synthesis protein
D3A95_RS10385	COG0517	IMP dehydrogenase activity
D3A95_RS10385	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
D3A95_RS10385	COG0617	tRNA 3'-terminal CCA addition
D3A95_RS10395	COG0616	signal peptide processing
D3A95_RS10410	COG1166	arginine decarboxylase activity
D3A95_RS10415	COG0439	Biotin carboxylase
D3A95_RS10420	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
D3A95_RS10425	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
D3A95_RS10430	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
D3A95_RS10445	COG4783	chaperone-mediated protein folding
D3A95_RS10450	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
D3A95_RS10475	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
D3A95_RS10480	COG0730	response to heat
D3A95_RS10485	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
D3A95_RS10495	COG0277	FAD linked oxidase domain protein
D3A95_RS10505	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
D3A95_RS10515	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
D3A95_RS10515	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D3A95_RS10525	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
D3A95_RS10530	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D3A95_RS10540	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
D3A95_RS10545	COG0037	tRNA processing
D3A95_RS10550	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
D3A95_RS10560	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
D3A95_RS10565	COG5001	Diguanylate cyclase
D3A95_RS10570	COG0336	Belongs to the RNA methyltransferase TrmD family
D3A95_RS10585	COG0789	Transcriptional regulator
D3A95_RS10600	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
D3A95_RS10605	COG0793	Belongs to the peptidase S41A family
D3A95_RS10610	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
D3A95_RS10620	COG2226	methyltransferase
D3A95_RS10625	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
D3A95_RS10625	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
D3A95_RS10630	COG1271	oxidase subunit
D3A95_RS10635	COG1294	oxidase, subunit
D3A95_RS10650	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
D3A95_RS10655	COG1215	transferase activity, transferring glycosyl groups
D3A95_RS10670	COG0653	protein targeting
D3A95_RS10680	COG0739	heme binding
D3A95_RS10685	COG1797	cobyrinic acid a,c-diamide synthase activity
D3A95_RS10695	COG1035	Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus
D3A95_RS10710	COG0675	Transposase, IS605 OrfB family
D3A95_RS10720	COG0003	Pfam Anion-transporting ATPase
D3A95_RS10725	COG4181	ATPase activity
D3A95_RS10735	COG0151	Belongs to the GarS family
D3A95_RS10755	COG2890	protein-(glutamine-N5) methyltransferase activity
D3A95_RS10765	COG0697	spore germination
D3A95_RS10775	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
D3A95_RS10780	COG5002	protein histidine kinase activity
D3A95_RS10790	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
D3A95_RS10795	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
D3A95_RS10800	COG0215	cysteine-tRNA ligase activity
D3A95_RS10805	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
D3A95_RS10810	COG2154	pterin-4-alpha-carbinolamine dehydratase
D3A95_RS10825	COG0681	Belongs to the peptidase S26 family
D3A95_RS10830	COG3001	Fructosamine kinase
D3A95_RS10840	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D3A95_RS10850	COG0651	ATP synthesis coupled electron transport
D3A95_RS10880	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
D3A95_RS10890	COG0114	fumarate hydratase activity
D3A95_RS10895	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
D3A95_RS10930	COG0589	response to stress
D3A95_RS10935	COG0457	Tetratricopeptide repeat
D3A95_RS10940	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
D3A95_RS10965	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
D3A95_RS10970	COG2211	Major facilitator Superfamily
D3A95_RS10975	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
D3A95_RS10980	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
D3A95_RS11000	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
D3A95_RS11005	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
D3A95_RS11020	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
D3A95_RS11035	COG1850	ribulose-bisphosphate carboxylase activity
D3A95_RS11050	COG0525	valine-tRNA ligase activity
D3A95_RS11055	COG1028	Short-chain dehydrogenase reductase Sdr
D3A95_RS11075	COG1672	PFAM Archaeal ATPase
D3A95_RS11075	COG2319	Wd-40 repeat
D3A95_RS11085	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
D3A95_RS11090	COG0837	glucose binding
D3A95_RS11105	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
D3A95_RS11115	COG0629	single-stranded DNA binding
D3A95_RS11150	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
D3A95_RS11160	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
D3A95_RS11165	COG0484	heat shock protein binding
D3A95_RS11170	COG0131	Imidazoleglycerol-phosphate dehydratase
D3A95_RS11185	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
D3A95_RS11200	COG2814	Major facilitator Superfamily
D3A95_RS11205	COG1672	PFAM Archaeal ATPase
D3A95_RS11210	COG4243	Vitamin k epoxide reductase
D3A95_RS11220	COG0009	L-threonylcarbamoyladenylate synthase
D3A95_RS11225	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
D3A95_RS11230	COG0038	chloride channel
D3A95_RS11240	COG0628	permease
D3A95_RS11245	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
D3A95_RS11250	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
D3A95_RS11260	COG0644	oxidoreductase
D3A95_RS11265	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
D3A95_RS11270	COG1132	(ABC) transporter
D3A95_RS11280	COG0589	response to stress
D3A95_RS11290	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
D3A95_RS11300	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
D3A95_RS11305	COG0134	indole-3-glycerol-phosphate synthase activity
D3A95_RS11310	COG3046	protein related to deoxyribodipyrimidine photolyase
D3A95_RS11320	COG1446	asparaginase
D3A95_RS11325	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D3A95_RS11340	COG1640	4-alpha-glucanotransferase
D3A95_RS11355	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
D3A95_RS11360	COG0137	argininosuccinate synthase activity
D3A95_RS11375	COG0617	tRNA 3'-terminal CCA addition
D3A95_RS11385	COG0166	Belongs to the GPI family
D3A95_RS11390	COG1073	alpha beta
D3A95_RS11395	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D3A95_RS11400	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
D3A95_RS11410	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
D3A95_RS11420	COG1716	ATPase activity
D3A95_RS11420	COG1131	(ABC) transporter
D3A95_RS11420	COG0842	Transport permease protein
D3A95_RS11435	COG0251	oxidation-reduction process
D3A95_RS11440	COG2885	chlorophyll binding
D3A95_RS11445	COG2885	chlorophyll binding
D3A95_RS11450	COG0668	transmembrane transport
D3A95_RS11480	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
D3A95_RS11485	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
D3A95_RS11495	COG1968	undecaprenyl-diphosphatase activity
D3A95_RS11510	COG3854	ATPases associated with a variety of cellular activities
D3A95_RS11520	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
D3A95_RS11540	COG0404	The glycine cleavage system catalyzes the degradation of glycine
D3A95_RS11545	COG1331	Highly conserved protein containing a thioredoxin domain
D3A95_RS11550	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
D3A95_RS11580	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
D3A95_RS11610	COG0484	heat shock protein binding
D3A95_RS11615	COG1175	transmembrane transport
D3A95_RS11620	COG0505	Belongs to the CarA family
D3A95_RS11625	COG1420	regulation of RNA biosynthetic process
D3A95_RS11635	COG0297	glycogen (starch) synthase activity
D3A95_RS11640	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
D3A95_RS11645	COG0574	Belongs to the PEP-utilizing enzyme family
D3A95_RS11645	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
D3A95_RS11655	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
D3A95_RS11670	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
D3A95_RS11685	COG0457	Tetratricopeptide repeat
D3A95_RS11690	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
D3A95_RS11695	COG1615	UPF0182 protein
D3A95_RS11710	COG1126	abc transporter atp-binding protein
D3A95_RS11735	COG0762	integral membrane protein
D3A95_RS11770	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
D3A95_RS11775	COG1366	Belongs to the anti-sigma-factor antagonist family
D3A95_RS11785	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
D3A95_RS11790	COG2205	protein histidine kinase activity
D3A95_RS11795	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
D3A95_RS11810	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
D3A95_RS11810	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
D3A95_RS11815	COG1562	ergosterol biosynthetic process
D3A95_RS11820	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
D3A95_RS11825	COG0540	Belongs to the ATCase OTCase family
D3A95_RS11835	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
D3A95_RS11840	COG0196	riboflavin kinase activity
D3A95_RS11845	COG0714	Associated with various cellular activities
D3A95_RS11860	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
D3A95_RS11865	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
D3A95_RS11885	COG0138	bifunctional purine biosynthesis protein purh
D3A95_RS11890	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
D3A95_RS11895	COG1175	transmembrane transport
D3A95_RS11920	COG0515	serine threonine protein kinase
D3A95_RS11920	COG1357	PFAM Pentapeptide repeats (8 copies)
D3A95_RS11925	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
D3A95_RS11930	COG0564	pseudouridine synthase activity
D3A95_RS11955	COG0358	DNA primase activity
D3A95_RS11960	COG0205	6-phosphofructokinase activity
D3A95_RS11965	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
D3A95_RS11970	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
D3A95_RS11975	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
D3A95_RS11980	COG5322	oxidoreductase activity
D3A95_RS11985	COG0825	malonyl-CoA metabolic process
D3A95_RS11990	COG0300	oxidoreductase activity
D3A95_RS11995	COG0302	gtp cyclohydrolase
D3A95_RS12020	COG1994	Peptidase M50
D3A95_RS12020	COG0517	IMP dehydrogenase activity
D3A95_RS12045	COG0335	large ribosomal subunit rRNA binding
D3A95_RS12050	COG0424	maF-like protein
D3A95_RS12055	COG1022	Amp-dependent synthetase and ligase
D3A95_RS12065	COG0508	dehydrogenase complex catalyzes the overall conversion of
D3A95_RS12070	COG1122	ATPase activity
D3A95_RS12080	COG0028	Belongs to the TPP enzyme family
D3A95_RS12085	COG0511	ligase activity, forming carbon-carbon bonds
D3A95_RS12090	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
D3A95_RS12100	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
D3A95_RS12110	COG1070	Carbohydrate kinase
D3A95_RS12115	COG1160	GTP binding
D3A95_RS12130	COG0649	NAD binding
D3A95_RS12135	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
D3A95_RS12145	COG2010	Cytochrome c
D3A95_RS12150	COG2010	Cytochrome c
D3A95_RS12185	COG0784	Response regulator, receiver
D3A95_RS12185	COG5002	protein histidine kinase activity
D3A95_RS12185	COG2198	Histidine kinase
D3A95_RS12190	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
D3A95_RS12200	COG0360	Binds together with S18 to 16S ribosomal RNA
D3A95_RS12205	COG0179	Fumarylacetoacetate (FAA) hydrolase
D3A95_RS12210	COG0175	sulfate reduction
D3A95_RS12215	COG0752	glycyl-tRNA synthetase alpha subunit
D3A95_RS12220	COG0726	polysaccharide deacetylase
D3A95_RS12230	COG0163	prenyltransferase activity
D3A95_RS12240	COG0702	epimerase
D3A95_RS12250	COG0646	methionine synthase
D3A95_RS12250	COG1410	methionine synthase
D3A95_RS12270	COG2010	Cytochrome c
D3A95_RS12280	COG0457	Tetratricopeptide repeat
D3A95_RS12280	COG0463	Glycosyl transferase, family 2
D3A95_RS12285	COG2205	protein histidine kinase activity
D3A95_RS12290	COG0820	rRNA (adenine-C2-)-methyltransferase activity
D3A95_RS12300	COG0745	RESPONSE REGULATOR receiver
D3A95_RS12310	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
D3A95_RS12315	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
D3A95_RS12320	COG0489	protein tyrosine kinase activity
D3A95_RS12325	COG0518	GMP synthase (glutamine-hydrolyzing) activity
D3A95_RS12325	COG0519	Catalyzes the synthesis of GMP from XMP
D3A95_RS12335	COG4572	Cation transport regulator
D3A95_RS12340	COG1372	Participates in initiation and elongation during chromosome replication
D3A95_RS12340	COG0305	Participates in initiation and elongation during chromosome replication
D3A95_RS12340	COG1372	Participates in initiation and elongation during chromosome replication
D3A95_RS12340	COG0305	Participates in initiation and elongation during chromosome replication
D3A95_RS12345	COG0359	binds to the 23S rRNA
D3A95_RS12365	COG1555	photosystem II stabilization
D3A95_RS12370	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
D3A95_RS12415	COG0469	pyruvate kinase activity
D3A95_RS12425	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
D3A95_RS12430	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
D3A95_RS12430	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
D3A95_RS12435	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
D3A95_RS12440	COG0372	Belongs to the citrate synthase family
D3A95_RS12445	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
D3A95_RS12455	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
D3A95_RS12465	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
D3A95_RS12470	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D3A95_RS12475	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
D3A95_RS12475	COG1116	anion transmembrane transporter activity
D3A95_RS12480	COG1116	anion transmembrane transporter activity
D3A95_RS12485	COG0243	molybdopterin cofactor binding
D3A95_RS12500	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
D3A95_RS12505	COG0583	DNA-binding transcription factor activity
D3A95_RS12510	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
D3A95_RS12515	COG0314	molybdopterin synthase activity
D3A95_RS12525	COG0746	molybdenum cofactor guanylyltransferase activity
D3A95_RS12525	COG0315	cyclic pyranopterin monophosphate synthase activity
D3A95_RS12530	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
D3A95_RS12535	COG0303	'Molybdopterin
D3A95_RS12540	COG0830	nickel cation binding
D3A95_RS12545	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
D3A95_RS12550	COG0784	Response regulator, receiver
D3A95_RS12550	COG2205	protein histidine kinase activity
D3A95_RS12555	COG0067	glutamate synthase
D3A95_RS12555	COG0069	glutamate synthase activity
D3A95_RS12555	COG0070	glutamate synthase
D3A95_RS12570	COG0863	Belongs to the N(4) N(6)-methyltransferase family
D3A95_RS12585	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
D3A95_RS12590	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
D3A95_RS12605	COG0426	domain, Protein
D3A95_RS12605	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
D3A95_RS12615	COG0419	ATPase involved in DNA repair
D3A95_RS12620	COG2027	D-alanyl-D-alanine carboxypeptidase
D3A95_RS12645	COG0395	ABC-type sugar transport system, permease component
D3A95_RS12650	COG0577	efflux transmembrane transporter activity
D3A95_RS12650	COG1136	(ABC) transporter
D3A95_RS12655	COG0193	aminoacyl-tRNA hydrolase activity
D3A95_RS12660	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
D3A95_RS12680	COG0542	response to heat
D3A95_RS12700	COG0745	RESPONSE REGULATOR receiver
D3A95_RS12725	COG0438	transferase activity, transferring glycosyl groups
D3A95_RS12755	COG0367	asparagine synthase
D3A95_RS12770	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
D3A95_RS12780	COG0489	protein tyrosine kinase activity
D3A95_RS12790	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
D3A95_RS12795	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
D3A95_RS12815	COG0121	glutamine amidotransferase
D3A95_RS12825	COG1304	FMN binding
D3A95_RS12830	COG0644	oxidoreductase
D3A95_RS12835	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
D3A95_RS12840	COG0793	Belongs to the peptidase S41A family
D3A95_RS12850	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
D3A95_RS12865	COG2340	Cysteine-rich secretory protein family
D3A95_RS12870	COG0459	protein refolding
D3A95_RS12875	COG1240	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
D3A95_RS12875	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
D3A95_RS12895	COG0310	cobalt ion transport
D3A95_RS12910	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D3A95_RS12920	COG0412	Dienelactone hydrolase
D3A95_RS12925	COG3063	Type IV pilus biogenesis stability protein PilW
D3A95_RS12935	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
D3A95_RS12950	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D3A95_RS12955	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient