locus-tag	class	description
FFX45_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
FFX45_RS00010	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
FFX45_RS00035	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
FFX45_RS00040	COG0701	Predicted permease
FFX45_RS00045	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
FFX45_RS00050	COG0783	Belongs to the Dps family
FFX45_RS00065	COG2133	pyrroloquinoline quinone binding
FFX45_RS00075	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
FFX45_RS00085	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
FFX45_RS00095	COG0573	inorganic phosphate transmembrane transporter activity
FFX45_RS00100	COG0581	inorganic phosphate transmembrane transporter activity
FFX45_RS00105	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
FFX45_RS00110	COG0154	amidase activity
FFX45_RS00120	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
FFX45_RS00140	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
FFX45_RS00160	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FFX45_RS00175	COG1216	Glycosyl transferase, family 2
FFX45_RS00200	COG0640	Transcriptional regulator
FFX45_RS00225	COG0537	adenosine 5'-monophosphoramidase activity
FFX45_RS00230	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
FFX45_RS00245	COG3706	GGDEF domain
FFX45_RS00255	COG0165	Argininosuccinate lyase
FFX45_RS00260	COG5398	heme oxygenase
FFX45_RS00280	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
FFX45_RS00295	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
FFX45_RS00330	COG4581	dead DEAH box helicase
FFX45_RS00335	COG0643	Histidine kinase
FFX45_RS00335	COG2198	Histidine kinase
FFX45_RS00335	COG0784	Response regulator, receiver
FFX45_RS00340	COG0840	transmembrane signaling receptor activity
FFX45_RS00365	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
FFX45_RS00380	COG0429	hydrolase of the alpha beta-hydrolase fold
FFX45_RS00390	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
FFX45_RS00400	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
FFX45_RS00415	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
FFX45_RS00420	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
FFX45_RS00430	COG0259	pyridoxamine-phosphate oxidase activity
FFX45_RS00435	COG0832	Belongs to the urease beta subunit family
FFX45_RS00450	COG0438	transferase activity, transferring glycosyl groups
FFX45_RS00455	COG2264	protein methyltransferase activity
FFX45_RS00460	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
FFX45_RS00465	COG0484	heat shock protein binding
FFX45_RS00500	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
FFX45_RS00505	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FFX45_RS00520	COG1595	DNA-templated transcription, initiation
FFX45_RS00535	COG0463	Glycosyl transferase, family 2
FFX45_RS00535	COG0457	Tetratricopeptide repeat
FFX45_RS00545	COG0210	DNA helicase
FFX45_RS00550	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
FFX45_RS00555	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
FFX45_RS00560	COG0542	response to heat
FFX45_RS00575	COG0481	GTPase activity
FFX45_RS00585	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
FFX45_RS00610	COG0328	RNA-DNA hybrid ribonuclease activity
FFX45_RS00615	COG0222	ribosome binding
FFX45_RS00620	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
FFX45_RS00625	COG0081	regulation of translation
FFX45_RS00630	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
FFX45_RS00635	COG0250	Participates in transcription elongation, termination and antitermination
FFX45_RS00670	COG2089	acid synthase
FFX45_RS00685	COG2089	acid synthase
FFX45_RS00690	COG3980	spore coat polysaccharide biosynthesis protein
FFX45_RS00695	COG1083	cytidylyl-transferase
FFX45_RS00705	COG0123	including yeast histone deacetylase and acetoin utilization protein
FFX45_RS00730	COG1086	Polysaccharide biosynthesis protein
FFX45_RS00745	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
FFX45_RS00755	COG0693	protein deglycase activity
FFX45_RS00770	COG1132	(ABC) transporter
FFX45_RS00790	COG4251	negative regulation of phosphorylation
FFX45_RS00800	COG2172	sigma factor antagonist activity
FFX45_RS00830	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
FFX45_RS00835	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
FFX45_RS00840	COG3429	Glucose-6-phosphate dehydrogenase subunit
FFX45_RS00840	COG3409	Peptidoglycan-binding domain 1 protein
FFX45_RS00870	COG0445	tRNA wobble uridine modification
FFX45_RS00895	COG0632	four-way junction helicase activity
FFX45_RS00905	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
FFX45_RS00910	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
FFX45_RS00915	COG0312	modulator of DNA gyrase
FFX45_RS00920	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
FFX45_RS00930	COG0355	proton-transporting ATP synthase activity, rotational mechanism
FFX45_RS00935	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
FFX45_RS00945	COG1181	Belongs to the D-alanine--D-alanine ligase family
FFX45_RS00960	COG0517	IMP dehydrogenase activity
FFX45_RS00960	COG0617	tRNA 3'-terminal CCA addition
FFX45_RS00960	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
FFX45_RS00965	COG0470	DNA polymerase III
FFX45_RS00990	COG1840	ABC-type Fe3 transport system, periplasmic component
FFX45_RS00995	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
FFX45_RS01010	COG0602	queuosine metabolic process
FFX45_RS01025	COG0237	dephospho-CoA kinase activity
FFX45_RS01030	COG2205	protein histidine kinase activity
FFX45_RS01055	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
FFX45_RS01060	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FFX45_RS01070	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
FFX45_RS01075	COG0189	ligase activity
FFX45_RS01080	COG2189	Belongs to the N(4) N(6)-methyltransferase family
FFX45_RS01090	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
FFX45_RS01100	COG1285	pathogenesis
FFX45_RS01105	COG2239	Acts as a magnesium transporter
FFX45_RS01125	COG1104	cysteine desulfurase activity
FFX45_RS01135	COG1555	photosystem II stabilization
FFX45_RS01135	COG1234	tRNA 3'-trailer cleavage
FFX45_RS01150	COG0596	Alpha beta hydrolase
FFX45_RS01170	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
FFX45_RS01180	COG2203	Gaf domain
FFX45_RS01180	COG3706	GGDEF domain
FFX45_RS01180	COG4251	negative regulation of phosphorylation
FFX45_RS01180	COG5001	Diguanylate cyclase
FFX45_RS01185	COG5002	protein histidine kinase activity
FFX45_RS01195	COG1218	3'(2'),5'-bisphosphate nucleotidase
FFX45_RS01200	COG0552	protein localization to endoplasmic reticulum
FFX45_RS01205	COG0436	Aminotransferase
FFX45_RS01210	COG1028	Short-chain dehydrogenase reductase Sdr
FFX45_RS01220	COG0741	lytic transglycosylase activity
FFX45_RS01235	COG1077	Cell shape determining protein MreB Mrl
FFX45_RS01255	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
FFX45_RS01260	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
FFX45_RS01265	COG4451	ribulose bisphosphate carboxylase, small
FFX45_RS01265	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
FFX45_RS01270	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
FFX45_RS01275	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
FFX45_RS01280	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
FFX45_RS01295	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
FFX45_RS01305	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
FFX45_RS01310	COG0805	protein transport
FFX45_RS01315	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
FFX45_RS01355	COG1132	(ABC) transporter
FFX45_RS01360	COG1192	Involved in chromosome partitioning
FFX45_RS01370	COG0149	triose-phosphate isomerase activity
FFX45_RS01385	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
FFX45_RS01390	COG1063	alcohol dehydrogenase
FFX45_RS01395	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
FFX45_RS01410	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
FFX45_RS01415	COG2048	Heterodisulfide reductase, subunit B
FFX45_RS01420	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
FFX45_RS01425	COG0831	urea catabolic process
FFX45_RS01430	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
FFX45_RS01435	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
FFX45_RS01445	COG1253	flavin adenine dinucleotide binding
FFX45_RS01460	COG1162	GTPase activity
FFX45_RS01475	COG1882	Formate acetyltransferase
FFX45_RS01480	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
FFX45_RS01490	COG1216	Glycosyl transferase, family 2
FFX45_RS01515	COG1108	ABC-type Mn2 Zn2 transport systems permease components
FFX45_RS01520	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
FFX45_RS01550	COG1116	anion transmembrane transporter activity
FFX45_RS01565	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
FFX45_RS01575	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FFX45_RS01590	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
FFX45_RS01600	COG0440	acetolactate synthase activity
FFX45_RS01610	COG1160	GTP binding
FFX45_RS01625	COG0271	Belongs to the BolA IbaG family
FFX45_RS01630	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
FFX45_RS01635	COG0071	Belongs to the small heat shock protein (HSP20) family
FFX45_RS01655	COG2006	4fe-4S ferredoxin, iron-sulfur binding domain protein
FFX45_RS01660	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FFX45_RS01665	COG0316	Belongs to the HesB IscA family
FFX45_RS01695	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
FFX45_RS01710	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
FFX45_RS01715	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
FFX45_RS01745	COG1045	serine acetyltransferase
FFX45_RS01750	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
FFX45_RS01775	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
FFX45_RS01780	COG0416	fatty acid biosynthetic process
FFX45_RS01785	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
FFX45_RS01810	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
FFX45_RS01815	COG0772	Belongs to the SEDS family
FFX45_RS01840	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
FFX45_RS01845	COG0321	lipoyl(octanoyl) transferase activity
FFX45_RS01850	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
FFX45_RS01860	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
FFX45_RS01860	COG3264	Mechanosensitive ion channel
FFX45_RS01880	COG0018	arginyl-trna synthetase
FFX45_RS01890	COG0717	Belongs to the dCTP deaminase family
FFX45_RS01895	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
FFX45_RS01905	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
FFX45_RS01915	COG1121	(ABC) transporter
FFX45_RS01920	COG1899	peptidyl-lysine modification to peptidyl-hypusine
FFX45_RS01930	COG2217	Heavy metal translocating P-type atpase
FFX45_RS01955	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
FFX45_RS01970	COG3118	belongs to the thioredoxin family
FFX45_RS01980	COG0747	negative chemotaxis
FFX45_RS01985	COG3956	TIGRFAM MazG family protein
FFX45_RS01990	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
FFX45_RS02015	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
FFX45_RS02030	COG0514	ATP-dependent DNA helicase (RecQ)
FFX45_RS02065	COG1666	GTP binding
FFX45_RS02075	COG0443	Heat shock 70 kDa protein
FFX45_RS02080	COG0484	heat shock protein binding
FFX45_RS02095	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
FFX45_RS02110	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
FFX45_RS02115	COG2223	nitrite transmembrane transporter activity
FFX45_RS02120	COG0058	SHG alpha-glucan phosphorylase activity
FFX45_RS02130	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
FFX45_RS02145	COG0442	prolyl-tRNA aminoacylation
FFX45_RS02155	COG0697	spore germination
FFX45_RS02160	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
FFX45_RS02175	COG0504	CTP synthase activity
FFX45_RS02185	COG1357	PFAM Pentapeptide repeats (8 copies)
FFX45_RS02185	COG0515	serine threonine protein kinase
FFX45_RS02190	COG0583	DNA-binding transcription factor activity
FFX45_RS02195	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
FFX45_RS02215	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
FFX45_RS02230	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FFX45_RS02235	COG5002	protein histidine kinase activity
FFX45_RS02240	COG1799	cell septum assembly
FFX45_RS02245	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
FFX45_RS02255	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FFX45_RS02260	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
FFX45_RS02275	COG0318	PFAM AMP-dependent synthetase and ligase
FFX45_RS02280	COG0799	negative regulation of ribosome biogenesis
FFX45_RS02285	COG3596	GTP binding
FFX45_RS02290	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
FFX45_RS02300	COG5002	protein histidine kinase activity
FFX45_RS02310	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
FFX45_RS02325	COG1857	crispr-associated protein
FFX45_RS02335	COG1203	CRISPR-associated helicase, Cas3
FFX45_RS02345	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
FFX45_RS02350	COG1518	maintenance of DNA repeat elements
FFX45_RS02350	COG1468	defense response to virus
FFX45_RS02370	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
FFX45_RS02375	COG0066	3-isopropylmalate dehydratase activity
FFX45_RS02405	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
FFX45_RS02420	COG0484	heat shock protein binding
FFX45_RS02435	COG1104	cysteine desulfurase activity
FFX45_RS02445	COG4802	Ferredoxin thioredoxin reductase catalytic beta chain
FFX45_RS02460	COG2814	Major facilitator Superfamily
FFX45_RS02475	COG0254	rRNA binding
FFX45_RS02480	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
FFX45_RS02485	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
FFX45_RS02490	COG0101	tRNA pseudouridine synthase activity
FFX45_RS02495	COG0203	ribosomal protein L17
FFX45_RS02500	COG0202	RNA polymerase activity
FFX45_RS02505	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
FFX45_RS02510	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
FFX45_RS02515	COG0257	Belongs to the bacterial ribosomal protein bL36 family
FFX45_RS02520	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
FFX45_RS02525	COG0563	adenylate kinase activity
FFX45_RS02530	COG0201	protein transport
FFX45_RS02535	COG0200	Binds to the 23S rRNA
FFX45_RS02540	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
FFX45_RS02545	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
FFX45_RS02550	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
FFX45_RS02555	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
FFX45_RS02560	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
FFX45_RS02565	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
FFX45_RS02570	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
FFX45_RS02575	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
FFX45_RS02580	COG0255	Belongs to the universal ribosomal protein uL29 family
FFX45_RS02585	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
FFX45_RS02590	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
FFX45_RS02595	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
FFX45_RS02600	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
FFX45_RS02605	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
FFX45_RS02610	COG0089	rRNA binding
FFX45_RS02615	COG0088	Forms part of the polypeptide exit tunnel
FFX45_RS02620	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
FFX45_RS02625	COG0343	queuine tRNA-ribosyltransferase activity
FFX45_RS02650	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
FFX45_RS02665	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
FFX45_RS02670	COG0628	permease
FFX45_RS02685	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
FFX45_RS02695	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
FFX45_RS02705	COG2022	thiamine diphosphate biosynthetic process
FFX45_RS02730	COG0420	3'-5' exonuclease activity
FFX45_RS02750	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
FFX45_RS02755	COG0848	biopolymer transport protein
FFX45_RS02760	COG0194	GDP metabolic process
FFX45_RS02780	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FFX45_RS02800	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
FFX45_RS02800	COG1754	DNA topoisomerase type I activity
FFX45_RS02810	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
FFX45_RS02820	COG0300	oxidoreductase activity
FFX45_RS02830	COG0109	protoheme IX farnesyltransferase activity
FFX45_RS02835	COG1612	heme a metabolic process
FFX45_RS02855	COG0124	histidyl-tRNA synthetase
FFX45_RS02865	COG0497	DNA recombination
FFX45_RS02875	COG1131	(ABC) transporter
FFX45_RS02880	COG3693	PFAM glycoside hydrolase, family 10
FFX45_RS02890	COG0396	ATPase activity
FFX45_RS02895	COG0719	Fe-S assembly protein
FFX45_RS02905	COG0716	FMN binding
FFX45_RS02915	COG3128	pkhd-type hydroxylase
FFX45_RS02925	COG5002	protein histidine kinase activity
FFX45_RS02935	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
FFX45_RS02945	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
FFX45_RS02955	COG0572	uridine kinase
FFX45_RS02960	COG0333	Belongs to the bacterial ribosomal protein bL32 family
FFX45_RS02985	COG2217	Heavy metal translocating P-type atpase
FFX45_RS02990	COG4636	protein conserved in cyanobacteria
FFX45_RS03010	COG0492	ferredoxin-NADP+ reductase activity
FFX45_RS03015	COG1196	nuclear chromosome segregation
FFX45_RS03025	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
FFX45_RS03030	COG0800	Aldolase
FFX45_RS03055	COG2045	Belongs to the ComB family
FFX45_RS03060	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
FFX45_RS03065	COG0598	Magnesium transport protein CorA
FFX45_RS03080	COG0857	belongs to the CobB CobQ family
FFX45_RS03110	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
FFX45_RS03135	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
FFX45_RS03140	COG2894	cell division
FFX45_RS03145	COG0850	regulation of cytokinetic process
FFX45_RS03155	COG0515	serine threonine protein kinase
FFX45_RS03210	COG1116	anion transmembrane transporter activity
FFX45_RS03215	COG1116	anion transmembrane transporter activity
FFX45_RS03215	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
FFX45_RS03225	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
FFX45_RS03230	COG5001	Diguanylate cyclase
FFX45_RS03245	COG0180	Tryptophanyl-tRNA synthetase
FFX45_RS03255	COG1872	DUF167
FFX45_RS03280	COG2205	protein histidine kinase activity
FFX45_RS03295	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
FFX45_RS03305	COG0004	ammonium transporteR
FFX45_RS03310	COG0220	tRNA (guanine-N7-)-methyltransferase activity
FFX45_RS03320	COG1234	tRNA 3'-trailer cleavage
FFX45_RS03340	COG0420	3'-5' exonuclease activity
FFX45_RS03345	COG0033	Phosphoglucomutase
FFX45_RS03360	COG1543	Belongs to the glycosyl hydrolase 57 family
FFX45_RS03365	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
FFX45_RS03375	COG2308	Evidence 4 Homologs of previously reported genes of
FFX45_RS03380	COG0525	valine-tRNA ligase activity
FFX45_RS03385	COG0519	Catalyzes the synthesis of GMP from XMP
FFX45_RS03385	COG0518	GMP synthase (glutamine-hydrolyzing) activity
FFX45_RS03390	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
FFX45_RS03400	COG0739	heme binding
FFX45_RS03405	COG0237	dephospho-CoA kinase activity
FFX45_RS03410	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
FFX45_RS03415	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
FFX45_RS03420	COG1413	lyase activity
FFX45_RS03425	COG1413	lyase activity
FFX45_RS03430	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
FFX45_RS03435	COG0237	dephospho-CoA kinase activity
FFX45_RS03450	COG1573	uracil-dna glycosylase
FFX45_RS03465	COG2226	methyltransferase
FFX45_RS03475	COG0391	Required for morphogenesis under gluconeogenic growth conditions
FFX45_RS03485	COG0354	folic acid binding
FFX45_RS03490	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
FFX45_RS03495	COG0352	thiamine-phosphate diphosphorylase activity
FFX45_RS03525	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
FFX45_RS03540	COG0779	Required for maturation of 30S ribosomal subunits
FFX45_RS03545	COG0195	Participates in both transcription termination and antitermination
FFX45_RS03555	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
FFX45_RS03565	COG0681	Belongs to the peptidase S26 family
FFX45_RS03580	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
FFX45_RS03600	COG0569	domain protein
FFX45_RS03615	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
FFX45_RS03625	COG1012	belongs to the aldehyde dehydrogenase family
FFX45_RS03650	COG0431	NADPH-dependent FMN reductase
FFX45_RS03655	COG0113	porphobilinogen synthase activity
FFX45_RS03665	COG0024	Methionine aminopeptidase
FFX45_RS03670	COG0415	Belongs to the DNA photolyase family
FFX45_RS03680	COG1366	Belongs to the anti-sigma-factor antagonist family
FFX45_RS03685	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
FFX45_RS03710	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
FFX45_RS03715	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
FFX45_RS03720	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
FFX45_RS03725	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
FFX45_RS03730	COG5002	protein histidine kinase activity
FFX45_RS03740	COG0159	tryptophan synthase activity
FFX45_RS03755	COG4172	Belongs to the ABC transporter superfamily
FFX45_RS03785	COG5002	protein histidine kinase activity
FFX45_RS03790	COG0745	RESPONSE REGULATOR receiver
FFX45_RS03795	COG0475	glutathione-regulated potassium exporter activity
FFX45_RS03800	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
FFX45_RS03805	COG0802	atpase or kinase
FFX45_RS03810	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
FFX45_RS03815	COG2177	Part of the ABC transporter FtsEX involved in
FFX45_RS03820	COG2884	Cell division ATP-binding protein ftsE
FFX45_RS03855	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
FFX45_RS03860	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
FFX45_RS03870	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
FFX45_RS03875	COG0316	Belongs to the HesB IscA family
FFX45_RS03880	COG1090	epimerase
FFX45_RS03890	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
FFX45_RS03905	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
FFX45_RS03920	COG0077	Prephenate dehydratase
FFX45_RS03925	COG0686	Belongs to the AlaDH PNT family
FFX45_RS03935	COG0575	Belongs to the CDS family
FFX45_RS03940	COG1595	DNA-templated transcription, initiation
FFX45_RS03950	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
FFX45_RS03990	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
FFX45_RS03995	COG0483	inositol monophosphate 1-phosphatase activity
FFX45_RS04020	COG0405	Gamma-glutamyltransferase
FFX45_RS04025	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
FFX45_RS04030	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FFX45_RS04040	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
FFX45_RS04045	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
FFX45_RS04050	COG1546	Belongs to the CinA family
FFX45_RS04050	COG1058	Belongs to the CinA family
FFX45_RS04075	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
FFX45_RS04130	COG0659	secondary active sulfate transmembrane transporter activity
FFX45_RS04135	COG2094	Belongs to the DNA glycosylase MPG family
FFX45_RS04145	COG0484	heat shock protein binding
FFX45_RS04150	COG0443	Heat shock 70 kDa protein
FFX45_RS04160	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
FFX45_RS04160	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
FFX45_RS04170	COG0739	heme binding
FFX45_RS04175	COG1587	Uroporphyrinogen-III synthase
FFX45_RS04185	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
FFX45_RS04190	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
FFX45_RS04195	COG0291	Belongs to the bacterial ribosomal protein bL35 family
FFX45_RS04205	COG2302	S4 RNA-binding domain
FFX45_RS04220	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
FFX45_RS04225	COG0573	inorganic phosphate transmembrane transporter activity
FFX45_RS04230	COG0581	inorganic phosphate transmembrane transporter activity
FFX45_RS04235	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
FFX45_RS04265	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
FFX45_RS04265	COG0189	ligase activity
FFX45_RS04270	COG3385	transposase activity
FFX45_RS04290	COG0419	ATPase involved in DNA repair
FFX45_RS04295	COG2304	oxidoreductase activity
FFX45_RS04305	COG1028	Short-chain dehydrogenase reductase Sdr
FFX45_RS04320	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
FFX45_RS04320	COG0546	phosphoglycolate phosphatase activity
FFX45_RS04330	COG3385	transposase activity
FFX45_RS04340	COG0628	permease
FFX45_RS04350	COG0450	alkyl hydroperoxide reductase
FFX45_RS04355	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
FFX45_RS04360	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
FFX45_RS04375	COG0482	sulfurtransferase activity
FFX45_RS04380	COG0724	RNA recognition motif
FFX45_RS04385	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
FFX45_RS04390	COG2255	four-way junction helicase activity
FFX45_RS04405	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
FFX45_RS04455	COG0793	Belongs to the peptidase S41A family
FFX45_RS04465	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
FFX45_RS04475	COG0631	protein serine/threonine phosphatase activity
FFX45_RS04480	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
FFX45_RS04490	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
FFX45_RS04500	COG2208	phosphoserine phosphatase activity
FFX45_RS04510	COG1381	Involved in DNA repair and RecF pathway recombination
FFX45_RS04525	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
FFX45_RS04530	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FFX45_RS04540	COG0515	serine threonine protein kinase
FFX45_RS04540	COG2815	serine threonine protein kinase
FFX45_RS04555	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
FFX45_RS04570	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
FFX45_RS04575	COG0443	Heat shock 70 kDa protein
FFX45_RS04590	COG0582	viral genome integration into host DNA
FFX45_RS04600	COG3781	membrane
FFX45_RS04605	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
FFX45_RS04610	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
FFX45_RS04615	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
FFX45_RS04620	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
FFX45_RS04625	COG0745	RESPONSE REGULATOR receiver
FFX45_RS04630	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
FFX45_RS04640	COG2166	iron-sulfur cluster assembly
FFX45_RS04645	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
FFX45_RS04655	COG0778	Nitroreductase
FFX45_RS04660	COG0456	acetyltransferase
FFX45_RS04670	COG1575	Belongs to the MenA family. Type 1 subfamily
FFX45_RS04685	COG1185	polyribonucleotide nucleotidyltransferase activity
FFX45_RS04690	COG0751	glycine-tRNA ligase activity
FFX45_RS04700	COG0516	GMP reductase activity
FFX45_RS04705	COG0791	NLP P60 protein
FFX45_RS04705	COG0741	lytic transglycosylase activity
FFX45_RS04720	COG0047	phosphoribosylformylglycinamidine synthase activity
FFX45_RS04730	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
FFX45_RS04735	COG0330	HflC and HflK could
FFX45_RS04740	COG3385	transposase activity
FFX45_RS04745	COG0006	proline dipeptidase activity
FFX45_RS04750	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
FFX45_RS04755	COG0776	regulation of translation
FFX45_RS04760	COG0126	phosphoglycerate kinase activity
FFX45_RS04765	COG0589	response to stress
FFX45_RS04785	COG0135	phosphoribosylanthranilate isomerase activity
FFX45_RS04800	COG0469	pyruvate kinase activity
FFX45_RS04805	COG0523	cobalamin synthesis protein
FFX45_RS04855	COG1217	gtp-binding protein TYPA
FFX45_RS04870	COG3118	belongs to the thioredoxin family
FFX45_RS04875	COG4399	Belongs to the UPF0754 family
FFX45_RS04885	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FFX45_RS04890	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
FFX45_RS04895	COG5505	Protein of unknown function (DUF819)
FFX45_RS04910	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
FFX45_RS04920	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
FFX45_RS04965	COG4279	zinc finger
FFX45_RS04975	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
FFX45_RS04980	COG1496	oxidoreductase activity
FFX45_RS04995	COG1657	PFAM Prenyltransferase squalene oxidase
FFX45_RS05000	COG4783	chaperone-mediated protein folding
FFX45_RS05020	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
FFX45_RS05025	COG0556	nucleotide-excision repair
FFX45_RS05035	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
FFX45_RS05045	COG0583	DNA-binding transcription factor activity
FFX45_RS05055	COG0170	dolichyl monophosphate biosynthetic process
FFX45_RS05060	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
FFX45_RS05100	COG0768	penicillin binding
FFX45_RS05110	COG0275	rRNA processing
FFX45_RS05135	COG0587	DNA-directed DNA polymerase activity
FFX45_RS05140	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
FFX45_RS05150	COG0596	Alpha beta hydrolase
FFX45_RS05165	COG1121	(ABC) transporter
FFX45_RS05170	COG0803	Belongs to the bacterial solute-binding protein 9 family
FFX45_RS05175	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
FFX45_RS05180	COG0267	Belongs to the bacterial ribosomal protein bL33 family
FFX45_RS05200	COG0587	DNA-directed DNA polymerase activity
FFX45_RS05205	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
FFX45_RS05215	COG2022	thiamine diphosphate biosynthetic process
FFX45_RS05215	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FFX45_RS05225	COG0371	Dehydrogenase
FFX45_RS05230	COG0436	Aminotransferase
FFX45_RS05235	COG3158	transport of potassium into the cell
FFX45_RS05245	COG1970	mechanosensitive ion channel activity
FFX45_RS05250	COG0539	negative regulation of cytoplasmic translation
FFX45_RS05255	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
FFX45_RS05275	COG3932	Exopolysaccharide synthesis, ExoD
FFX45_RS05285	COG0058	SHG alpha-glucan phosphorylase activity
FFX45_RS05295	COG0714	Associated with various cellular activities
FFX45_RS05325	COG3118	belongs to the thioredoxin family
FFX45_RS05335	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
FFX45_RS05355	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
FFX45_RS05360	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FFX45_RS05380	COG0495	leucyl-tRNA aminoacylation
FFX45_RS05410	COG0436	Aminotransferase
FFX45_RS05415	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
FFX45_RS05420	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
FFX45_RS05430	COG5001	Diguanylate cyclase
FFX45_RS05430	COG3706	GGDEF domain
FFX45_RS05430	COG2203	Gaf domain
FFX45_RS05430	COG4251	negative regulation of phosphorylation
FFX45_RS05440	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
FFX45_RS05465	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
FFX45_RS05470	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
FFX45_RS05485	COG0824	Thioesterase
FFX45_RS05495	COG0719	Fe-S assembly protein
FFX45_RS05515	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
FFX45_RS05520	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
FFX45_RS05530	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
FFX45_RS05540	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
FFX45_RS05545	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
FFX45_RS05550	COG1108	ABC-type Mn2 Zn2 transport systems permease components
FFX45_RS05555	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
FFX45_RS05560	COG1959	2 iron, 2 sulfur cluster binding
FFX45_RS05565	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
FFX45_RS05580	COG1192	Involved in chromosome partitioning
FFX45_RS05585	COG0052	Belongs to the universal ribosomal protein uS2 family
FFX45_RS05590	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
FFX45_RS05595	COG0307	riboflavin synthase, alpha
FFX45_RS05605	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
FFX45_RS05610	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
FFX45_RS05615	COG0454	-acetyltransferase
FFX45_RS05625	COG0248	Ppx GppA phosphatase
FFX45_RS05630	COG0559	Belongs to the binding-protein-dependent transport system permease family
FFX45_RS05635	COG0509	glycine decarboxylation via glycine cleavage system
FFX45_RS05645	COG0242	peptide deformylase activity
FFX45_RS05665	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
FFX45_RS05670	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
FFX45_RS05680	COG3063	Type IV pilus biogenesis stability protein PilW
FFX45_RS05695	COG0815	Transfers the fatty acyl group on membrane lipoproteins
FFX45_RS05710	COG0277	FAD linked oxidase domain protein
FFX45_RS05715	COG0247	lactate metabolic process
FFX45_RS05730	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
FFX45_RS05735	COG5002	protein histidine kinase activity
FFX45_RS05745	COG0483	inositol monophosphate 1-phosphatase activity
FFX45_RS05750	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
FFX45_RS05785	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
FFX45_RS05805	COG0181	hydroxymethylbilane synthase activity
FFX45_RS05820	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
FFX45_RS05830	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
FFX45_RS05840	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FFX45_RS05855	COG1218	3'(2'),5'-bisphosphate nucleotidase
FFX45_RS05870	COG0772	Belongs to the SEDS family
FFX45_RS05880	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
FFX45_RS05885	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
FFX45_RS05890	COG0012	GTP binding
FFX45_RS05895	COG0174	glutamine synthetase
FFX45_RS05905	COG0438	transferase activity, transferring glycosyl groups
FFX45_RS05910	COG0438	transferase activity, transferring glycosyl groups
FFX45_RS05925	COG0515	serine threonine protein kinase
FFX45_RS05940	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
FFX45_RS05945	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
FFX45_RS05960	COG0473	3-isopropylmalate dehydrogenase activity
FFX45_RS05980	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
FFX45_RS06005	COG1982	Orn Lys Arg decarboxylase major
FFX45_RS06025	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
FFX45_RS06030	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
FFX45_RS06035	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FFX45_RS06040	COG0557	exoribonuclease II activity
FFX45_RS06045	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
FFX45_RS06055	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
FFX45_RS06085	COG4956	integral membrane protein (PIN domain superfamily)
FFX45_RS06110	COG1473	amidohydrolase
FFX45_RS06115	COG2954	triphosphatase activity
FFX45_RS06125	COG2211	Major facilitator Superfamily
FFX45_RS06140	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
FFX45_RS06150	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
FFX45_RS06160	COG2832	Protein of unknown function (DUF454)
FFX45_RS06190	COG2205	protein histidine kinase activity
FFX45_RS06200	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FFX45_RS06225	COG1702	phosphate starvation-inducible protein PhoH
FFX45_RS06230	COG0828	Belongs to the bacterial ribosomal protein bS21 family
FFX45_RS06240	COG0228	four-way junction DNA binding
FFX45_RS06245	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
FFX45_RS06250	COG0204	Acyl-transferase
FFX45_RS06250	COG0318	PFAM AMP-dependent synthetase and ligase
FFX45_RS06255	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
FFX45_RS06260	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
FFX45_RS06260	COG0425	Belongs to the sulfur carrier protein TusA family
FFX45_RS06265	COG1007	ATP synthesis coupled electron transport
FFX45_RS06270	COG1619	proteins homologs of microcin C7 resistance protein MccF
FFX45_RS06280	COG0735	belongs to the Fur family
FFX45_RS06285	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
FFX45_RS06290	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
FFX45_RS06300	COG0612	Peptidase, M16
FFX45_RS06315	COG0131	Imidazoleglycerol-phosphate dehydratase
FFX45_RS06325	COG0133	tryptophan synthase activity
FFX45_RS06330	COG0017	Asparaginyl-tRNA synthetase
FFX45_RS06335	COG1193	negative regulation of DNA recombination
FFX45_RS06355	COG5001	Diguanylate cyclase
FFX45_RS06360	COG3536	Protein conserved in bacteria
FFX45_RS06365	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
FFX45_RS06370	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
FFX45_RS06385	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
FFX45_RS06390	COG0227	Belongs to the bacterial ribosomal protein bL28 family
FFX45_RS06420	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
FFX45_RS06445	COG0542	response to heat
FFX45_RS06450	COG1192	Involved in chromosome partitioning
FFX45_RS06470	COG0745	RESPONSE REGULATOR receiver
FFX45_RS06480	COG0528	UMP kinase activity
FFX45_RS06485	COG0233	cytoplasmic translational termination
FFX45_RS06495	COG2385	sporulation resulting in formation of a cellular spore
FFX45_RS06505	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
FFX45_RS06520	COG0284	orotidine-5'-phosphate decarboxylase activity
FFX45_RS06545	COG4636	protein conserved in cyanobacteria
FFX45_RS06555	COG2197	response regulator
FFX45_RS06560	COG3659	wide pore channel activity
FFX45_RS06565	COG0793	Belongs to the peptidase S41A family
FFX45_RS06570	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
FFX45_RS06590	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
FFX45_RS06595	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
FFX45_RS06620	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
FFX45_RS06625	COG1834	amidinotransferase
FFX45_RS06630	COG0544	peptidyl-prolyl cis-trans isomerase activity
FFX45_RS06635	COG0740	serine-type endopeptidase activity
FFX45_RS06640	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
FFX45_RS06660	COG2226	methyltransferase
FFX45_RS06665	COG0589	response to stress
FFX45_RS06680	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
FFX45_RS06685	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FFX45_RS06685	COG2022	thiamine diphosphate biosynthetic process
FFX45_RS06695	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
FFX45_RS06700	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
FFX45_RS06700	COG0237	dephospho-CoA kinase activity
FFX45_RS06705	COG0745	RESPONSE REGULATOR receiver
FFX45_RS06730	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
FFX45_RS06735	COG1216	Glycosyl transferase, family 2
FFX45_RS06745	COG0436	Aminotransferase
FFX45_RS06755	COG1940	carbohydrate kinase activity
FFX45_RS06760	COG1316	TRANSCRIPTIONal
FFX45_RS06765	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
FFX45_RS06775	COG5002	protein histidine kinase activity
FFX45_RS06780	COG0728	peptidoglycan biosynthetic process
FFX45_RS06785	COG0592	DNA-directed DNA polymerase activity
FFX45_RS06800	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
FFX45_RS06810	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
FFX45_RS06835	COG1376	ErfK ybiS ycfS ynhG family protein
FFX45_RS06845	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
FFX45_RS06855	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
FFX45_RS06860	COG2252	PERMEase
FFX45_RS06890	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
FFX45_RS06895	COG2052	Domain of unknown function (DUF370)
FFX45_RS06935	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
FFX45_RS06955	COG1842	Phage shock protein A
FFX45_RS06960	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
FFX45_RS06970	COG4447	cellulose binding
FFX45_RS06975	COG1773	rubredoxin
FFX45_RS06980	COG1489	DNA binding
FFX45_RS07005	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
FFX45_RS07020	COG0357	Ribosomal RNA small subunit methyltransferase G
FFX45_RS07030	COG3659	wide pore channel activity
FFX45_RS07035	COG2003	Belongs to the UPF0758 family
FFX45_RS07040	COG2326	polyphosphate kinase activity
FFX45_RS07050	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
FFX45_RS07060	COG1178	ABC-type Fe3 transport system permease component
FFX45_RS07065	COG0157	Belongs to the NadC ModD family
FFX45_RS07070	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
FFX45_RS07080	COG1492	cobalamin metabolic process
FFX45_RS07100	COG0635	Involved in the biosynthesis of porphyrin-containing compound
FFX45_RS07105	COG5398	heme oxygenase
FFX45_RS07110	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
FFX45_RS07140	COG3150	esterase
FFX45_RS07145	COG2226	methyltransferase
FFX45_RS07150	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
FFX45_RS07150	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
FFX45_RS07170	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
FFX45_RS07175	COG0443	Heat shock 70 kDa protein
FFX45_RS07190	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
FFX45_RS07190	COG3264	Mechanosensitive ion channel
FFX45_RS07195	COG0792	nuclease activity
FFX45_RS07200	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
FFX45_RS07210	COG3977	Valine--pyruvate aminotransferase
FFX45_RS07215	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FFX45_RS07225	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
FFX45_RS07230	COG1385	rRNA (uridine-N3-)-methyltransferase activity
FFX45_RS07235	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
FFX45_RS07240	COG0049	tRNA binding
FFX45_RS07245	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
FFX45_RS07250	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
FFX45_RS07255	COG0051	transcription antitermination factor activity, RNA binding
FFX45_RS07265	COG0322	excinuclease ABC activity
FFX45_RS07275	COG0347	Belongs to the P(II) protein family
FFX45_RS07285	COG1742	UPF0060 membrane protein
FFX45_RS07290	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
FFX45_RS07295	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
FFX45_RS07300	COG3842	ATPase activity
FFX45_RS07305	COG0142	geranyltranstransferase activity
FFX45_RS07310	COG1316	TRANSCRIPTIONal
FFX45_RS07315	COG0740	serine-type endopeptidase activity
FFX45_RS07325	COG0019	diaminopimelate decarboxylase activity
FFX45_RS07335	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
FFX45_RS07340	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
FFX45_RS07345	COG0083	homoserine kinase activity
FFX45_RS07365	COG1136	(ABC) transporter
FFX45_RS07380	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
FFX45_RS07385	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
FFX45_RS07385	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
FFX45_RS07405	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
FFX45_RS07425	COG0387	Pfam Sodium calcium exchanger
FFX45_RS07430	COG4372	Transposase
FFX45_RS07440	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
FFX45_RS07460	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
FFX45_RS07465	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
FFX45_RS07470	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FFX45_RS07475	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
FFX45_RS07490	COG1215	transferase activity, transferring glycosyl groups
FFX45_RS07495	COG1215	transferase activity, transferring glycosyl groups
FFX45_RS07505	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
FFX45_RS07515	COG4636	protein conserved in cyanobacteria
FFX45_RS07520	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
FFX45_RS07525	COG2843	Capsule synthesis protein
FFX45_RS07530	COG0517	IMP dehydrogenase activity
FFX45_RS07530	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
FFX45_RS07540	COG0616	signal peptide processing
FFX45_RS07555	COG1166	arginine decarboxylase activity
FFX45_RS07560	COG0439	Biotin carboxylase
FFX45_RS07565	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
FFX45_RS07570	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
FFX45_RS07575	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
FFX45_RS07595	COG0628	permease
FFX45_RS07605	COG0038	chloride channel
FFX45_RS07610	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
FFX45_RS07615	COG0009	L-threonylcarbamoyladenylate synthase
FFX45_RS07625	COG4243	Vitamin k epoxide reductase
FFX45_RS07630	COG1672	PFAM Archaeal ATPase
FFX45_RS07635	COG2814	Major facilitator Superfamily
FFX45_RS07650	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
FFX45_RS07665	COG0131	Imidazoleglycerol-phosphate dehydratase
FFX45_RS07670	COG0484	heat shock protein binding
FFX45_RS07675	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
FFX45_RS07685	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
FFX45_RS07695	COG0419	ATPase involved in DNA repair
FFX45_RS07710	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
FFX45_RS07720	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
FFX45_RS07730	COG1606	tRNA processing
FFX45_RS07740	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
FFX45_RS07740	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
FFX45_RS07745	COG3659	wide pore channel activity
FFX45_RS07750	COG0523	cobalamin synthesis protein
FFX45_RS07800	COG0745	RESPONSE REGULATOR receiver
FFX45_RS07810	COG0842	Transport permease protein
FFX45_RS07810	COG1131	(ABC) transporter
FFX45_RS07810	COG1716	ATPase activity
FFX45_RS07825	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
FFX45_RS07840	COG0601	transmembrane transport
FFX45_RS07845	COG0629	single-stranded DNA binding
FFX45_RS07855	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
FFX45_RS07870	COG0837	glucose binding
FFX45_RS07875	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
FFX45_RS07885	COG2319	Wd-40 repeat
FFX45_RS07885	COG1672	PFAM Archaeal ATPase
FFX45_RS07915	COG1028	Short-chain dehydrogenase reductase Sdr
FFX45_RS07920	COG0525	valine-tRNA ligase activity
FFX45_RS07925	COG4451	ribulose bisphosphate carboxylase, small
FFX45_RS07935	COG1850	ribulose-bisphosphate carboxylase activity
FFX45_RS07960	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
FFX45_RS07975	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
FFX45_RS07980	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
FFX45_RS08005	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
FFX45_RS08010	COG2211	Major facilitator Superfamily
FFX45_RS08015	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
FFX45_RS08035	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
FFX45_RS08040	COG0457	Tetratricopeptide repeat
FFX45_RS08045	COG0589	response to stress
FFX45_RS08075	COG0406	alpha-ribazole phosphatase activity
FFX45_RS08080	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
FFX45_RS08085	COG0114	fumarate hydratase activity
FFX45_RS08110	COG3385	transposase activity
FFX45_RS08120	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
FFX45_RS08155	COG0651	ATP synthesis coupled electron transport
FFX45_RS08165	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FFX45_RS08175	COG3001	Fructosamine kinase
FFX45_RS08195	COG2205	protein histidine kinase activity
FFX45_RS08200	COG0681	Belongs to the peptidase S26 family
FFX45_RS08215	COG2154	pterin-4-alpha-carbinolamine dehydratase
FFX45_RS08220	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
FFX45_RS08225	COG0215	cysteine-tRNA ligase activity
FFX45_RS08230	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
FFX45_RS08235	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
FFX45_RS08245	COG1716	ATPase activity
FFX45_RS08245	COG5001	Diguanylate cyclase
FFX45_RS08250	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
FFX45_RS08255	COG0527	aspartate kinase activity
FFX45_RS08260	COG0697	spore germination
FFX45_RS08270	COG2890	protein-(glutamine-N5) methyltransferase activity
FFX45_RS08290	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
FFX45_RS08310	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
FFX45_RS08315	COG0601	transmembrane transport
FFX45_RS08325	COG0457	Tetratricopeptide repeat
FFX45_RS08330	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
FFX45_RS08335	COG1615	UPF0182 protein
FFX45_RS08365	COG0151	Belongs to the GarS family
FFX45_RS08375	COG4181	ATPase activity
FFX45_RS08380	COG0003	Pfam Anion-transporting ATPase
FFX45_RS08395	COG1035	Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus
FFX45_RS08405	COG1797	cobyrinic acid a,c-diamide synthase activity
FFX45_RS08410	COG0739	heme binding
FFX45_RS08420	COG0653	protein targeting
FFX45_RS08435	COG1215	transferase activity, transferring glycosyl groups
FFX45_RS08440	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
FFX45_RS08455	COG1294	oxidase, subunit
FFX45_RS08460	COG1271	oxidase subunit
FFX45_RS08465	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
FFX45_RS08465	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
FFX45_RS08470	COG2226	methyltransferase
FFX45_RS08480	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
FFX45_RS08485	COG0793	Belongs to the peptidase S41A family
FFX45_RS08490	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
FFX45_RS08505	COG0336	Belongs to the RNA methyltransferase TrmD family
FFX45_RS08510	COG5001	Diguanylate cyclase
FFX45_RS08515	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
FFX45_RS08525	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
FFX45_RS08530	COG0037	tRNA processing
FFX45_RS08535	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
FFX45_RS08545	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FFX45_RS08550	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
FFX45_RS08560	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
FFX45_RS08560	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FFX45_RS08570	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
FFX45_RS08580	COG0277	FAD linked oxidase domain protein
FFX45_RS08590	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
FFX45_RS08595	COG0730	response to heat
FFX45_RS08600	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
FFX45_RS08620	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
FFX45_RS08625	COG4783	chaperone-mediated protein folding
FFX45_RS08640	COG0788	formyltetrahydrofolate deformylase activity
FFX45_RS08645	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
FFX45_RS08650	COG0459	protein refolding
FFX45_RS08655	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
FFX45_RS08660	COG0395	ABC-type sugar transport system, permease component
FFX45_RS08670	COG0285	dihydrofolate synthase activity
FFX45_RS08680	COG0735	belongs to the Fur family
FFX45_RS08695	COG2205	protein histidine kinase activity
FFX45_RS08730	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
FFX45_RS08735	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
FFX45_RS08740	COG0022	dehydrogenase e1 component
FFX45_RS08740	COG0508	dehydrogenase complex catalyzes the overall conversion of
FFX45_RS08750	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
FFX45_RS08755	COG0625	glutathione transferase activity
FFX45_RS08765	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
FFX45_RS08765	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
FFX45_RS08775	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
FFX45_RS08780	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
FFX45_RS08785	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
FFX45_RS08790	COG1132	(ABC) transporter
FFX45_RS08795	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
FFX45_RS08810	COG0484	heat shock protein binding
FFX45_RS08820	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
FFX45_RS08820	COG0758	DNA mediated transformation
FFX45_RS08825	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FFX45_RS08830	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FFX45_RS08845	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
FFX45_RS08855	COG3063	Type IV pilus biogenesis stability protein PilW
FFX45_RS08860	COG0412	Dienelactone hydrolase
FFX45_RS08870	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
FFX45_RS08885	COG0310	cobalt ion transport
FFX45_RS08910	COG1240	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
FFX45_RS08910	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
FFX45_RS08915	COG0459	protein refolding
FFX45_RS08920	COG2340	Cysteine-rich secretory protein family
FFX45_RS08935	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
FFX45_RS08945	COG0793	Belongs to the peptidase S41A family
FFX45_RS08950	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
FFX45_RS08955	COG0644	oxidoreductase
FFX45_RS08960	COG1304	FMN binding
FFX45_RS08970	COG0121	glutamine amidotransferase
FFX45_RS08990	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
FFX45_RS08995	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
FFX45_RS09005	COG0489	protein tyrosine kinase activity
FFX45_RS09015	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
FFX45_RS09030	COG0367	asparagine synthase
FFX45_RS09035	COG0438	transferase activity, transferring glycosyl groups
FFX45_RS09055	COG0463	Glycosyl transferase, family 2
FFX45_RS09060	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
FFX45_RS09085	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
FFX45_RS09090	COG0546	phosphoglycolate phosphatase activity
FFX45_RS09135	COG0542	response to heat
FFX45_RS09155	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
FFX45_RS09160	COG0193	aminoacyl-tRNA hydrolase activity
FFX45_RS09165	COG0577	efflux transmembrane transporter activity
FFX45_RS09165	COG1136	(ABC) transporter
FFX45_RS09170	COG0395	ABC-type sugar transport system, permease component
FFX45_RS09185	COG1053	succinate dehydrogenase
FFX45_RS09195	COG2027	D-alanyl-D-alanine carboxypeptidase
FFX45_RS09200	COG0426	domain, Protein
FFX45_RS09200	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
FFX45_RS09215	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FFX45_RS09220	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
FFX45_RS09225	COG0069	glutamate synthase activity
FFX45_RS09225	COG0067	glutamate synthase
FFX45_RS09225	COG0070	glutamate synthase
FFX45_RS09230	COG2205	protein histidine kinase activity
FFX45_RS09230	COG0784	Response regulator, receiver
FFX45_RS09235	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
FFX45_RS09240	COG0830	nickel cation binding
FFX45_RS09245	COG0303	'Molybdopterin
FFX45_RS09250	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
FFX45_RS09255	COG0315	cyclic pyranopterin monophosphate synthase activity
FFX45_RS09255	COG0746	molybdenum cofactor guanylyltransferase activity
FFX45_RS09265	COG0314	molybdopterin synthase activity
FFX45_RS09280	COG0583	DNA-binding transcription factor activity
FFX45_RS09285	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
FFX45_RS09300	COG0243	molybdopterin cofactor binding
FFX45_RS09305	COG1116	anion transmembrane transporter activity
FFX45_RS09310	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
FFX45_RS09310	COG1116	anion transmembrane transporter activity
FFX45_RS09315	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
FFX45_RS09320	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
FFX45_RS09330	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
FFX45_RS09340	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
FFX45_RS09345	COG0372	Belongs to the citrate synthase family
FFX45_RS09350	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
FFX45_RS09355	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
FFX45_RS09355	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
FFX45_RS09360	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
FFX45_RS09370	COG0469	pyruvate kinase activity
FFX45_RS09415	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
FFX45_RS09420	COG1555	photosystem II stabilization
FFX45_RS09440	COG0359	binds to the 23S rRNA
FFX45_RS09445	COG0305	Participates in initiation and elongation during chromosome replication
FFX45_RS09445	COG0305	Participates in initiation and elongation during chromosome replication
FFX45_RS09445	COG1372	Participates in initiation and elongation during chromosome replication
FFX45_RS09445	COG1372	Participates in initiation and elongation during chromosome replication
FFX45_RS09450	COG4572	Cation transport regulator
FFX45_RS09460	COG0518	GMP synthase (glutamine-hydrolyzing) activity
FFX45_RS09460	COG0519	Catalyzes the synthesis of GMP from XMP
FFX45_RS09470	COG0489	protein tyrosine kinase activity
FFX45_RS09475	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
FFX45_RS09480	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
FFX45_RS09490	COG0745	RESPONSE REGULATOR receiver
FFX45_RS09500	COG0820	rRNA (adenine-C2-)-methyltransferase activity
FFX45_RS09505	COG0457	Tetratricopeptide repeat
FFX45_RS09505	COG0463	Glycosyl transferase, family 2
FFX45_RS09515	COG2010	Cytochrome c
FFX45_RS09525	COG1397	ADP-ribosylglycohydrolase
FFX45_RS09530	COG0646	methionine synthase
FFX45_RS09530	COG1410	methionine synthase
FFX45_RS09540	COG0702	epimerase
FFX45_RS09550	COG0163	prenyltransferase activity
FFX45_RS09560	COG0726	polysaccharide deacetylase
FFX45_RS09565	COG0752	glycyl-tRNA synthetase alpha subunit
FFX45_RS09570	COG0175	sulfate reduction
FFX45_RS09590	COG0179	Fumarylacetoacetate (FAA) hydrolase
FFX45_RS09595	COG0360	Binds together with S18 to 16S ribosomal RNA
FFX45_RS09605	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
FFX45_RS09610	COG0784	Response regulator, receiver
FFX45_RS09610	COG2205	protein histidine kinase activity
FFX45_RS09610	COG5002	protein histidine kinase activity
FFX45_RS09620	COG2010	Cytochrome c
FFX45_RS09625	COG2010	Cytochrome c
FFX45_RS09635	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
FFX45_RS09640	COG0649	NAD binding
FFX45_RS09655	COG1160	GTP binding
FFX45_RS09660	COG1070	Carbohydrate kinase
FFX45_RS09670	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
FFX45_RS09675	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
FFX45_RS09680	COG0511	ligase activity, forming carbon-carbon bonds
FFX45_RS09685	COG0028	Belongs to the TPP enzyme family
FFX45_RS09695	COG1122	ATPase activity
FFX45_RS09700	COG0508	dehydrogenase complex catalyzes the overall conversion of
FFX45_RS09715	COG0424	maF-like protein
FFX45_RS09720	COG0335	large ribosomal subunit rRNA binding
FFX45_RS09735	COG0517	IMP dehydrogenase activity
FFX45_RS09735	COG1994	Peptidase M50
FFX45_RS09760	COG0302	gtp cyclohydrolase
FFX45_RS09765	COG0300	oxidoreductase activity
FFX45_RS09770	COG0825	malonyl-CoA metabolic process
FFX45_RS09775	COG5322	oxidoreductase activity
FFX45_RS09780	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
FFX45_RS09795	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
FFX45_RS09800	COG0205	6-phosphofructokinase activity
FFX45_RS09805	COG0358	DNA primase activity
FFX45_RS09815	COG3256	nitric oxide reductase
FFX45_RS09865	COG4804	nuclease activity
FFX45_RS09890	COG0564	pseudouridine synthase activity
FFX45_RS09895	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
FFX45_RS09925	COG1175	transmembrane transport
FFX45_RS09930	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
FFX45_RS09935	COG0138	bifunctional purine biosynthesis protein purh
FFX45_RS09960	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
FFX45_RS09965	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
FFX45_RS09975	COG0714	Associated with various cellular activities
FFX45_RS09980	COG0196	riboflavin kinase activity
FFX45_RS09985	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
FFX45_RS09995	COG0540	Belongs to the ATCase OTCase family
FFX45_RS10000	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
FFX45_RS10005	COG1562	ergosterol biosynthetic process
FFX45_RS10010	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
FFX45_RS10010	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
FFX45_RS10025	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
FFX45_RS10030	COG2205	protein histidine kinase activity
FFX45_RS10035	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
FFX45_RS10045	COG1366	Belongs to the anti-sigma-factor antagonist family
FFX45_RS10050	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
FFX45_RS10060	COG1137	ATPase activity
FFX45_RS10120	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
FFX45_RS10150	COG0501	Belongs to the peptidase M48B family
FFX45_RS10155	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
FFX45_RS10160	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
FFX45_RS10165	COG0085	RNA polymerase activity
FFX45_RS10175	COG1136	(ABC) transporter
FFX45_RS10175	COG0577	efflux transmembrane transporter activity
FFX45_RS10185	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FFX45_RS10200	COG0187	DNA topoisomerase II activity
FFX45_RS10200	COG1372	Participates in initiation and elongation during chromosome replication
FFX45_RS10205	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
FFX45_RS10210	COG0519	Catalyzes the synthesis of GMP from XMP
FFX45_RS10210	COG0518	GMP synthase (glutamine-hydrolyzing) activity
FFX45_RS10225	COG0557	exoribonuclease II activity
FFX45_RS10240	COG1132	(ABC) transporter
FFX45_RS10245	COG1187	pseudouridine synthase activity
FFX45_RS10250	COG2217	Heavy metal translocating P-type atpase
FFX45_RS10255	COG0148	phosphopyruvate hydratase activity
FFX45_RS10260	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
FFX45_RS10270	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
FFX45_RS10275	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FFX45_RS10275	COG0072	phenylalanine-tRNA ligase activity
FFX45_RS10280	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
FFX45_RS10285	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
FFX45_RS10290	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FFX45_RS10295	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
FFX45_RS10300	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
FFX45_RS10305	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FFX45_RS10310	COG0839	Belongs to the complex I subunit 6 family
FFX45_RS10315	COG0713	ATP synthesis coupled electron transport
FFX45_RS10320	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FFX45_RS10325	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
FFX45_RS10400	COG2217	Heavy metal translocating P-type atpase
FFX45_RS10410	COG1333	cytochrome c biogenesis protein
FFX45_RS10415	COG0408	coproporphyrinogen oxidase activity
FFX45_RS10425	COG1376	ErfK ybiS ycfS ynhG family protein
FFX45_RS10435	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
FFX45_RS10440	COG1192	Involved in chromosome partitioning
FFX45_RS10445	COG1049	propionate catabolic process, 2-methylcitrate cycle
FFX45_RS10450	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
FFX45_RS10455	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
FFX45_RS10470	COG3411	Ferredoxin
FFX45_RS10480	COG3842	ATPase activity
FFX45_RS10500	COG0211	Belongs to the bacterial ribosomal protein bL27 family
FFX45_RS10505	COG0261	This protein binds to 23S rRNA in the presence of protein L20
FFX45_RS10515	COG1959	2 iron, 2 sulfur cluster binding
FFX45_RS10535	COG2082	Precorrin-8x methylmutase
FFX45_RS10550	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
FFX45_RS10560	COG0671	phosphoesterase, PA-phosphatase related
FFX45_RS10565	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
FFX45_RS10590	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
FFX45_RS10605	COG0745	RESPONSE REGULATOR receiver
FFX45_RS10620	COG2062	phosphohistidine phosphatase, SixA
FFX45_RS10635	COG3631	Ketosteroid isomerase-related protein
FFX45_RS10665	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
FFX45_RS10675	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
FFX45_RS10680	COG1494	fructose-1,6-bisphosphatase
FFX45_RS10690	COG1063	alcohol dehydrogenase
FFX45_RS10725	COG0724	RNA recognition motif
FFX45_RS10735	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
FFX45_RS10750	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
FFX45_RS10765	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
FFX45_RS10780	COG0450	alkyl hydroperoxide reductase
FFX45_RS10785	COG0765	amino acid transport
FFX45_RS10790	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
FFX45_RS10820	COG0515	serine threonine protein kinase
FFX45_RS10820	COG3266	domain, Protein
FFX45_RS10830	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
FFX45_RS10850	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
FFX45_RS10855	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
FFX45_RS10875	COG0512	Glutamine amidotransferase of anthranilate synthase
FFX45_RS10875	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
FFX45_RS10885	COG1131	(ABC) transporter
FFX45_RS10915	COG0635	Involved in the biosynthesis of porphyrin-containing compound
FFX45_RS10930	COG1691	(AIR) carboxylase
FFX45_RS10935	COG0268	Binds directly to 16S ribosomal RNA
FFX45_RS10940	COG0084	hydrolase, TatD family'
FFX45_RS10945	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
FFX45_RS10950	COG0107	imidazoleglycerol-phosphate synthase activity
FFX45_RS10960	COG0768	penicillin binding
FFX45_RS10970	COG0339	signal peptide processing
FFX45_RS11035	COG2385	sporulation resulting in formation of a cellular spore
FFX45_RS11050	COG2119	membrane
FFX45_RS11085	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
FFX45_RS11100	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
FFX45_RS11105	COG0812	UDP-N-acetylmuramate dehydrogenase activity
FFX45_RS11110	COG0457	Tetratricopeptide repeat
FFX45_RS11110	COG0463	Glycosyl transferase, family 2
FFX45_RS11115	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
FFX45_RS11115	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
FFX45_RS11125	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
FFX45_RS11135	COG1441	menaquinone biosynthetic process
FFX45_RS11145	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
FFX45_RS11145	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
FFX45_RS11150	COG0217	transcriptional regulatory protein
FFX45_RS11165	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
FFX45_RS11170	COG0434	BtpA family
FFX45_RS11175	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
FFX45_RS11180	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
FFX45_RS11185	COG0484	heat shock protein binding
FFX45_RS11195	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
FFX45_RS11205	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
FFX45_RS11210	COG1012	belongs to the aldehyde dehydrogenase family
FFX45_RS11220	COG4178	(ABC) transporter
FFX45_RS11235	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
FFX45_RS11240	COG1012	belongs to the aldehyde dehydrogenase family
FFX45_RS11240	COG1454	alcohol dehydrogenase
FFX45_RS11245	COG0095	Lipoate-protein ligase
FFX45_RS11260	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
FFX45_RS11270	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
FFX45_RS11270	COG0140	phosphoribosyl-ATP diphosphatase activity
FFX45_RS11290	COG0842	Transport permease protein
FFX45_RS11290	COG1716	ATPase activity
FFX45_RS11290	COG1131	(ABC) transporter
FFX45_RS11295	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
FFX45_RS11295	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
FFX45_RS11300	COG0612	Peptidase, M16
FFX45_RS11305	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
FFX45_RS11335	COG0156	8-amino-7-oxononanoate synthase activity
FFX45_RS11340	COG0745	RESPONSE REGULATOR receiver
FFX45_RS11350	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
FFX45_RS11360	COG1357	PFAM Pentapeptide repeats (8 copies)
FFX45_RS11360	COG0515	serine threonine protein kinase
FFX45_RS11380	COG0704	Plays a role in the regulation of phosphate uptake
FFX45_RS11425	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
FFX45_RS11440	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
FFX45_RS11445	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
FFX45_RS11450	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
FFX45_RS11460	COG1472	Belongs to the glycosyl hydrolase 3 family
FFX45_RS11465	COG2046	Belongs to the sulfate adenylyltransferase family
FFX45_RS11480	COG0438	transferase activity, transferring glycosyl groups
FFX45_RS11485	COG0745	RESPONSE REGULATOR receiver
FFX45_RS11530	COG1528	Iron-storage protein
FFX45_RS11535	COG0742	ribosomal rna small subunit methyltransferase
FFX45_RS11545	COG0667	Aldo Keto reductase
FFX45_RS11555	COG2099	Precorrin-6x reductase
FFX45_RS11560	COG0129	dihydroxy-acid dehydratase activity
FFX45_RS11580	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
FFX45_RS11600	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
FFX45_RS11605	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
FFX45_RS11620	COG0612	Peptidase, M16
FFX45_RS11625	COG5001	Diguanylate cyclase
FFX45_RS11625	COG1716	ATPase activity
FFX45_RS11630	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
FFX45_RS11645	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
FFX45_RS11705	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
FFX45_RS11710	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
FFX45_RS11715	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FFX45_RS11725	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
FFX45_RS11750	COG4991	sh3 domain protein
FFX45_RS11750	COG3064	Membrane
FFX45_RS11750	COG0515	serine threonine protein kinase
FFX45_RS11795	COG0426	domain, Protein
FFX45_RS11795	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
FFX45_RS11800	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
FFX45_RS11835	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
FFX45_RS11850	COG0363	glucosamine-6-phosphate deaminase activity
FFX45_RS11875	COG0740	serine-type endopeptidase activity
FFX45_RS11880	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
FFX45_RS11885	COG0765	amino acid transport
FFX45_RS11890	COG5433	transposase activity
FFX45_RS11895	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
FFX45_RS11900	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
FFX45_RS11910	COG0644	oxidoreductase
FFX45_RS11915	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
FFX45_RS11920	COG1132	(ABC) transporter
FFX45_RS11925	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
FFX45_RS11930	COG0589	response to stress
FFX45_RS11940	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
FFX45_RS11955	COG0134	indole-3-glycerol-phosphate synthase activity
FFX45_RS11960	COG3046	protein related to deoxyribodipyrimidine photolyase
FFX45_RS11970	COG1446	asparaginase
FFX45_RS11975	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FFX45_RS11990	COG1640	4-alpha-glucanotransferase
FFX45_RS12005	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
FFX45_RS12010	COG0137	argininosuccinate synthase activity
FFX45_RS12025	COG0617	tRNA 3'-terminal CCA addition
FFX45_RS12035	COG0166	Belongs to the GPI family
FFX45_RS12040	COG1073	alpha beta
FFX45_RS12045	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FFX45_RS12050	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
FFX45_RS12060	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
FFX45_RS12085	COG0251	oxidation-reduction process
FFX45_RS12090	COG2885	chlorophyll binding
FFX45_RS12095	COG2885	chlorophyll binding
FFX45_RS12100	COG0668	transmembrane transport
FFX45_RS12105	COG0302	gtp cyclohydrolase
FFX45_RS12110	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
FFX45_RS12115	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
FFX45_RS12125	COG1968	undecaprenyl-diphosphatase activity
FFX45_RS12140	COG3854	ATPases associated with a variety of cellular activities
FFX45_RS12155	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
FFX45_RS12175	COG0404	The glycine cleavage system catalyzes the degradation of glycine
FFX45_RS12180	COG1331	Highly conserved protein containing a thioredoxin domain
FFX45_RS12185	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
FFX45_RS12215	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FFX45_RS12245	COG0484	heat shock protein binding
FFX45_RS12250	COG1175	transmembrane transport
FFX45_RS12255	COG0505	Belongs to the CarA family
FFX45_RS12260	COG1420	regulation of RNA biosynthetic process
FFX45_RS12270	COG0297	glycogen (starch) synthase activity
FFX45_RS12275	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
FFX45_RS12280	COG0574	Belongs to the PEP-utilizing enzyme family
FFX45_RS12280	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
FFX45_RS12290	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
FFX45_RS12300	COG1192	Involved in chromosome partitioning
FFX45_RS12330	COG0515	serine threonine protein kinase
FFX45_RS12335	COG1716	ATPase activity
FFX45_RS12340	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
FFX45_RS12345	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
FFX45_RS12355	COG0596	Alpha beta hydrolase
FFX45_RS12370	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
FFX45_RS12380	COG0745	RESPONSE REGULATOR receiver
FFX45_RS12385	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FFX45_RS12395	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
FFX45_RS12400	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
FFX45_RS12405	COG2081	HI0933 family
FFX45_RS12410	COG0668	transmembrane transport
FFX45_RS12420	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
FFX45_RS12435	COG5002	protein histidine kinase activity
FFX45_RS12475	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
FFX45_RS12480	COG1252	NADH dehydrogenase
FFX45_RS12500	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
FFX45_RS12520	COG0515	serine threonine protein kinase
FFX45_RS12520	COG1357	PFAM Pentapeptide repeats (8 copies)
FFX45_RS12530	COG0515	serine threonine protein kinase
FFX45_RS12545	COG0287	Prephenate dehydrogenase
FFX45_RS12550	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FFX45_RS12565	COG1122	ATPase activity
FFX45_RS12575	COG1930	Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import
FFX45_RS12580	COG0310	cobalt ion transport
FFX45_RS12585	COG1799	cell septum assembly
FFX45_RS12595	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
FFX45_RS12610	COG1473	amidohydrolase
FFX45_RS12625	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
FFX45_RS12625	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
FFX45_RS12635	COG2268	Band 7 protein
FFX45_RS12640	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
FFX45_RS12650	COG0384	phenazine biosynthesis protein PhzF
FFX45_RS12655	COG0105	UTP biosynthetic process
FFX45_RS12660	COG0861	Integral membrane protein TerC family
FFX45_RS12665	COG0275	rRNA processing
FFX45_RS12675	COG1122	ATPase activity
FFX45_RS12680	COG1429	ligase activity, forming nitrogen-metal bonds
FFX45_RS12690	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
FFX45_RS12695	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
FFX45_RS12700	COG4208	sulfate ABC transporter
FFX45_RS12705	COG0460	homoserine dehydrogenase
FFX45_RS12715	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
FFX45_RS12720	COG0484	heat shock protein binding
FFX45_RS12725	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
FFX45_RS12735	COG1842	Phage shock protein A
FFX45_RS12740	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
FFX45_RS12745	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
FFX45_RS12760	COG0446	pyridine nucleotide-disulphide oxidoreductase
FFX45_RS12765	COG0629	single-stranded DNA binding
FFX45_RS12770	COG2852	Protein conserved in bacteria
FFX45_RS12785	COG2198	Histidine kinase
FFX45_RS12785	COG0784	Response regulator, receiver
FFX45_RS12785	COG0643	Histidine kinase
FFX45_RS12790	COG0840	transmembrane signaling receptor activity
FFX45_RS12790	COG2203	Gaf domain
FFX45_RS12805	COG0784	Response regulator, receiver
FFX45_RS12820	COG3659	wide pore channel activity
FFX45_RS12830	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
FFX45_RS12835	COG1028	Short-chain dehydrogenase reductase Sdr
FFX45_RS12845	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
FFX45_RS12850	COG1132	(ABC) transporter
FFX45_RS12855	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
FFX45_RS12860	COG0167	dihydroorotate dehydrogenase activity
FFX45_RS12870	COG1122	ATPase activity
FFX45_RS12875	COG0438	transferase activity, transferring glycosyl groups
FFX45_RS12880	COG0515	serine threonine protein kinase
FFX45_RS12885	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
FFX45_RS12885	COG0574	Belongs to the PEP-utilizing enzyme family
FFX45_RS12890	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
FFX45_RS12900	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
FFX45_RS12910	COG4243	Vitamin k epoxide reductase
FFX45_RS12915	COG0745	RESPONSE REGULATOR receiver
FFX45_RS12925	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
FFX45_RS12935	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
FFX45_RS12960	COG1530	ribonuclease E activity
FFX45_RS12965	COG2066	Belongs to the glutaminase family
FFX45_RS12975	COG0706	membrane insertase activity
FFX45_RS12980	COG0594	ribonuclease P activity
FFX45_RS12985	COG0230	Belongs to the bacterial ribosomal protein bL34 family