locus-tag	class	description
NBE99_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
NBE99_RS00010	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
NBE99_RS00025	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
NBE99_RS00035	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
NBE99_RS00040	COG0701	Predicted permease
NBE99_RS00045	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
NBE99_RS00050	COG0783	Belongs to the Dps family
NBE99_RS00065	COG2133	pyrroloquinoline quinone binding
NBE99_RS00075	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
NBE99_RS00085	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
NBE99_RS00090	COG3385	transposase activity
NBE99_RS00100	COG0573	inorganic phosphate transmembrane transporter activity
NBE99_RS00105	COG0581	inorganic phosphate transmembrane transporter activity
NBE99_RS00110	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
NBE99_RS00115	COG0154	amidase activity
NBE99_RS00125	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
NBE99_RS00145	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
NBE99_RS00155	COG4968	Prepilin-type N-terminal cleavage methylation domain
NBE99_RS00160	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
NBE99_RS00180	COG0404	The glycine cleavage system catalyzes the degradation of glycine
NBE99_RS00185	COG1331	Highly conserved protein containing a thioredoxin domain
NBE99_RS00190	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
NBE99_RS00220	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
NBE99_RS00250	COG0484	heat shock protein binding
NBE99_RS00255	COG1175	transmembrane transport
NBE99_RS00260	COG0505	Belongs to the CarA family
NBE99_RS00265	COG1420	regulation of RNA biosynthetic process
NBE99_RS00275	COG0297	glycogen (starch) synthase activity
NBE99_RS00280	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
NBE99_RS00285	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
NBE99_RS00285	COG0574	Belongs to the PEP-utilizing enzyme family
NBE99_RS00295	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
NBE99_RS00305	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
NBE99_RS00310	COG0601	transmembrane transport
NBE99_RS00320	COG0457	Tetratricopeptide repeat
NBE99_RS00325	COG1215	transferase activity, transferring glycosyl groups
NBE99_RS00330	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
NBE99_RS00335	COG1615	UPF0182 protein
NBE99_RS00340	COG0635	Involved in the biosynthesis of porphyrin-containing compound
NBE99_RS00355	COG1691	(AIR) carboxylase
NBE99_RS00360	COG0268	Binds directly to 16S ribosomal RNA
NBE99_RS00365	COG0084	hydrolase, TatD family'
NBE99_RS00370	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
NBE99_RS00375	COG0107	imidazoleglycerol-phosphate synthase activity
NBE99_RS00385	COG0768	penicillin binding
NBE99_RS00390	COG0739	heme binding
NBE99_RS00390	COG1196	nuclear chromosome segregation
NBE99_RS00390	COG0741	lytic transglycosylase activity
NBE99_RS00395	COG0339	signal peptide processing
NBE99_RS00420	COG0860	N-Acetylmuramoyl-L-alanine amidase
NBE99_RS00420	COG2247	cell wall binding repeat
NBE99_RS00460	COG2385	sporulation resulting in formation of a cellular spore
NBE99_RS00475	COG2119	membrane
NBE99_RS00510	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
NBE99_RS00550	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
NBE99_RS00560	COG1136	(ABC) transporter
NBE99_RS00560	COG0577	efflux transmembrane transporter activity
NBE99_RS00570	COG0085	RNA polymerase activity
NBE99_RS00575	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
NBE99_RS00580	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
NBE99_RS00585	COG0501	Belongs to the peptidase M48B family
NBE99_RS00615	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
NBE99_RS00620	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
NBE99_RS00640	COG0612	Peptidase, M16
NBE99_RS00645	COG5001	Diguanylate cyclase
NBE99_RS00645	COG1716	ATPase activity
NBE99_RS00650	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
NBE99_RS00665	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
NBE99_RS00720	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
NBE99_RS00725	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
NBE99_RS00730	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
NBE99_RS00740	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
NBE99_RS00765	COG3064	Membrane
NBE99_RS00765	COG0515	serine threonine protein kinase
NBE99_RS00765	COG4991	sh3 domain protein
NBE99_RS00815	COG0426	domain, Protein
NBE99_RS00815	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
NBE99_RS00820	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
NBE99_RS00850	COG1126	abc transporter atp-binding protein
NBE99_RS00855	COG0765	amino acid transport
NBE99_RS00865	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
NBE99_RS00885	COG0363	glucosamine-6-phosphate deaminase activity
NBE99_RS00910	COG0740	serine-type endopeptidase activity
NBE99_RS00915	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
NBE99_RS00920	COG0765	amino acid transport
NBE99_RS00930	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
NBE99_RS00935	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
NBE99_RS00955	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
NBE99_RS00975	COG0129	dihydroxy-acid dehydratase activity
NBE99_RS00980	COG2099	Precorrin-6x reductase
NBE99_RS00990	COG0667	Aldo Keto reductase
NBE99_RS00995	COG2203	Gaf domain
NBE99_RS00995	COG3706	GGDEF domain
NBE99_RS00995	COG4251	negative regulation of phosphorylation
NBE99_RS00995	COG5001	Diguanylate cyclase
NBE99_RS01005	COG0742	ribosomal rna small subunit methyltransferase
NBE99_RS01010	COG1528	Iron-storage protein
NBE99_RS01060	COG0745	RESPONSE REGULATOR receiver
NBE99_RS01065	COG0438	transferase activity, transferring glycosyl groups
NBE99_RS01080	COG2046	Belongs to the sulfate adenylyltransferase family
NBE99_RS01090	COG1472	Belongs to the glycosyl hydrolase 3 family
NBE99_RS01100	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
NBE99_RS01105	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
NBE99_RS01110	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
NBE99_RS01125	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
NBE99_RS01140	COG0175	sulfate reduction
NBE99_RS01145	COG0752	glycyl-tRNA synthetase alpha subunit
NBE99_RS01150	COG0726	polysaccharide deacetylase
NBE99_RS01160	COG0163	prenyltransferase activity
NBE99_RS01170	COG0702	epimerase
NBE99_RS01180	COG0646	methionine synthase
NBE99_RS01180	COG1410	methionine synthase
NBE99_RS01200	COG0519	Catalyzes the synthesis of GMP from XMP
NBE99_RS01200	COG0518	GMP synthase (glutamine-hydrolyzing) activity
NBE99_RS01215	COG0557	exoribonuclease II activity
NBE99_RS01230	COG1132	(ABC) transporter
NBE99_RS01240	COG1187	pseudouridine synthase activity
NBE99_RS01245	COG2217	Heavy metal translocating P-type atpase
NBE99_RS01250	COG0148	phosphopyruvate hydratase activity
NBE99_RS01255	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
NBE99_RS01265	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
NBE99_RS01270	COG0072	phenylalanine-tRNA ligase activity
NBE99_RS01270	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
NBE99_RS01275	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
NBE99_RS01280	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
NBE99_RS01285	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
NBE99_RS01300	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
NBE99_RS01305	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
NBE99_RS01310	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
NBE99_RS01315	COG0839	Belongs to the complex I subunit 6 family
NBE99_RS01320	COG0713	ATP synthesis coupled electron transport
NBE99_RS01325	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
NBE99_RS01330	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
NBE99_RS01385	COG2217	Heavy metal translocating P-type atpase
NBE99_RS01395	COG1333	cytochrome c biogenesis protein
NBE99_RS01400	COG0408	coproporphyrinogen oxidase activity
NBE99_RS01420	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
NBE99_RS01425	COG1192	Involved in chromosome partitioning
NBE99_RS01430	COG1049	propionate catabolic process, 2-methylcitrate cycle
NBE99_RS01435	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
NBE99_RS01440	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
NBE99_RS01445	COG0475	glutathione-regulated potassium exporter activity
NBE99_RS01455	COG3411	Ferredoxin
NBE99_RS01465	COG3842	ATPase activity
NBE99_RS01485	COG0211	Belongs to the bacterial ribosomal protein bL27 family
NBE99_RS01490	COG0261	This protein binds to 23S rRNA in the presence of protein L20
NBE99_RS01500	COG1959	2 iron, 2 sulfur cluster binding
NBE99_RS01520	COG2082	Precorrin-8x methylmutase
NBE99_RS01535	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
NBE99_RS01545	COG0671	phosphoesterase, PA-phosphatase related
NBE99_RS01550	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
NBE99_RS01575	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
NBE99_RS01590	COG0745	RESPONSE REGULATOR receiver
NBE99_RS01605	COG2062	phosphohistidine phosphatase, SixA
NBE99_RS01620	COG3631	Ketosteroid isomerase-related protein
NBE99_RS01650	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
NBE99_RS01660	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
NBE99_RS01665	COG1494	fructose-1,6-bisphosphatase
NBE99_RS01690	COG1063	alcohol dehydrogenase
NBE99_RS01705	COG1361	Conserved repeat domain
NBE99_RS01720	COG0724	RNA recognition motif
NBE99_RS01730	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
NBE99_RS01745	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
NBE99_RS01755	COG3177	Filamentation induced by cAMP protein fic
NBE99_RS01765	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
NBE99_RS01780	COG0450	alkyl hydroperoxide reductase
NBE99_RS01785	COG0765	amino acid transport
NBE99_RS01790	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
NBE99_RS01820	COG0515	serine threonine protein kinase
NBE99_RS01830	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
NBE99_RS01850	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
NBE99_RS01855	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
NBE99_RS01875	COG0512	Glutamine amidotransferase of anthranilate synthase
NBE99_RS01875	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
NBE99_RS01885	COG1131	(ABC) transporter
NBE99_RS01950	COG0515	serine threonine protein kinase
NBE99_RS01955	COG1716	ATPase activity
NBE99_RS01960	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
NBE99_RS01965	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
NBE99_RS01975	COG0596	Alpha beta hydrolase
NBE99_RS01995	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
NBE99_RS02005	COG0745	RESPONSE REGULATOR receiver
NBE99_RS02010	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
NBE99_RS02015	COG3385	transposase activity
NBE99_RS02025	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
NBE99_RS02030	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
NBE99_RS02035	COG2081	HI0933 family
NBE99_RS02040	COG0668	transmembrane transport
NBE99_RS02050	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
NBE99_RS02065	COG5002	protein histidine kinase activity
NBE99_RS02115	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
NBE99_RS02120	COG1252	NADH dehydrogenase
NBE99_RS02140	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
NBE99_RS02165	COG1357	PFAM Pentapeptide repeats (8 copies)
NBE99_RS02165	COG0515	serine threonine protein kinase
NBE99_RS02175	COG0515	serine threonine protein kinase
NBE99_RS02190	COG0287	Prephenate dehydrogenase
NBE99_RS02195	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
NBE99_RS02210	COG1122	ATPase activity
NBE99_RS02220	COG1930	Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import
NBE99_RS02225	COG0310	cobalt ion transport
NBE99_RS02230	COG1799	cell septum assembly
NBE99_RS02240	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
NBE99_RS02255	COG1473	amidohydrolase
NBE99_RS02270	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
NBE99_RS02270	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
NBE99_RS02280	COG2268	Band 7 protein
NBE99_RS02285	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
NBE99_RS02295	COG0384	phenazine biosynthesis protein PhzF
NBE99_RS02300	COG0105	UTP biosynthetic process
NBE99_RS02305	COG0861	Integral membrane protein TerC family
NBE99_RS02315	COG1122	ATPase activity
NBE99_RS02320	COG1429	ligase activity, forming nitrogen-metal bonds
NBE99_RS02330	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
NBE99_RS02335	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
NBE99_RS02340	COG4208	sulfate ABC transporter
NBE99_RS02345	COG0460	homoserine dehydrogenase
NBE99_RS02355	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
NBE99_RS02360	COG0484	heat shock protein binding
NBE99_RS02365	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
NBE99_RS02375	COG1842	Phage shock protein A
NBE99_RS02380	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
NBE99_RS02385	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
NBE99_RS02400	COG0446	pyridine nucleotide-disulphide oxidoreductase
NBE99_RS02405	COG0629	single-stranded DNA binding
NBE99_RS02430	COG0250	Participates in transcription elongation, termination and antitermination
NBE99_RS02435	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
NBE99_RS02440	COG0081	regulation of translation
NBE99_RS02445	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
NBE99_RS02450	COG0222	ribosome binding
NBE99_RS02455	COG0328	RNA-DNA hybrid ribonuclease activity
NBE99_RS02475	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
NBE99_RS02485	COG0481	GTPase activity
NBE99_RS02500	COG0542	response to heat
NBE99_RS02505	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
NBE99_RS02510	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
NBE99_RS02515	COG0210	DNA helicase
NBE99_RS02525	COG0457	Tetratricopeptide repeat
NBE99_RS02525	COG0463	Glycosyl transferase, family 2
NBE99_RS02535	COG1132	(ABC) transporter
NBE99_RS02540	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
NBE99_RS02545	COG0589	response to stress
NBE99_RS02555	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
NBE99_RS02570	COG0134	indole-3-glycerol-phosphate synthase activity
NBE99_RS02575	COG3046	protein related to deoxyribodipyrimidine photolyase
NBE99_RS02585	COG1446	asparaginase
NBE99_RS02590	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
NBE99_RS02605	COG1640	4-alpha-glucanotransferase
NBE99_RS02620	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
NBE99_RS02625	COG0137	argininosuccinate synthase activity
NBE99_RS02640	COG0617	tRNA 3'-terminal CCA addition
NBE99_RS02650	COG0166	Belongs to the GPI family
NBE99_RS02660	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
NBE99_RS02665	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
NBE99_RS02675	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
NBE99_RS02685	COG0842	Transport permease protein
NBE99_RS02685	COG1131	(ABC) transporter
NBE99_RS02685	COG1716	ATPase activity
NBE99_RS02700	COG0251	oxidation-reduction process
NBE99_RS02705	COG2885	chlorophyll binding
NBE99_RS02710	COG2885	chlorophyll binding
NBE99_RS02720	COG0668	transmembrane transport
NBE99_RS02730	COG3385	transposase activity
NBE99_RS02740	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
NBE99_RS02745	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
NBE99_RS02755	COG1968	undecaprenyl-diphosphatase activity
NBE99_RS02760	COG1191	sigma factor activity
NBE99_RS02770	COG3854	ATPases associated with a variety of cellular activities
NBE99_RS02775	COG2201	protein-glutamate methylesterase activity
NBE99_RS02780	COG2201	protein-glutamate methylesterase activity
NBE99_RS02800	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
NBE99_RS02810	COG0463	Glycosyl transferase, family 2
NBE99_RS02815	COG0463	Glycosyl transferase, family 2
NBE99_RS02825	COG0640	Transcriptional regulator
NBE99_RS02845	COG0840	transmembrane signaling receptor activity
NBE99_RS02845	COG2203	Gaf domain
NBE99_RS02885	COG0559	Belongs to the binding-protein-dependent transport system permease family
NBE99_RS02890	COG0559	Belongs to the binding-protein-dependent transport system permease family
NBE99_RS02900	COG0537	adenosine 5'-monophosphoramidase activity
NBE99_RS02905	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
NBE99_RS02930	COG0165	Argininosuccinate lyase
NBE99_RS02935	COG5398	heme oxygenase
NBE99_RS02960	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
NBE99_RS02975	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
NBE99_RS03010	COG4581	dead DEAH box helicase
NBE99_RS03015	COG0784	Response regulator, receiver
NBE99_RS03015	COG2198	Histidine kinase
NBE99_RS03015	COG0643	Histidine kinase
NBE99_RS03020	COG0840	transmembrane signaling receptor activity
NBE99_RS03045	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
NBE99_RS03060	COG0429	hydrolase of the alpha beta-hydrolase fold
NBE99_RS03070	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
NBE99_RS03080	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
NBE99_RS03095	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
NBE99_RS03110	COG0259	pyridoxamine-phosphate oxidase activity
NBE99_RS03115	COG0832	Belongs to the urease beta subunit family
NBE99_RS03130	COG0438	transferase activity, transferring glycosyl groups
NBE99_RS03135	COG2264	protein methyltransferase activity
NBE99_RS03140	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
NBE99_RS03145	COG0484	heat shock protein binding
NBE99_RS03180	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
NBE99_RS03185	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
NBE99_RS03200	COG1595	DNA-templated transcription, initiation
NBE99_RS03205	COG0811	peptide transport
NBE99_RS03210	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
NBE99_RS03215	COG0644	oxidoreductase
NBE99_RS03225	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
NBE99_RS03230	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
NBE99_RS03235	COG0628	permease
NBE99_RS03245	COG0038	chloride channel
NBE99_RS03250	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
NBE99_RS03255	COG0009	L-threonylcarbamoyladenylate synthase
NBE99_RS03265	COG4243	Vitamin k epoxide reductase
NBE99_RS03270	COG1672	PFAM Archaeal ATPase
NBE99_RS03275	COG2814	Major facilitator Superfamily
NBE99_RS03290	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
NBE99_RS03305	COG0131	Imidazoleglycerol-phosphate dehydratase
NBE99_RS03310	COG0484	heat shock protein binding
NBE99_RS03315	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
NBE99_RS03325	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
NBE99_RS03335	COG0419	ATPase involved in DNA repair
NBE99_RS03355	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
NBE99_RS03365	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
NBE99_RS03375	COG1606	tRNA processing
NBE99_RS03385	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
NBE99_RS03385	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
NBE99_RS03390	COG3659	wide pore channel activity
NBE99_RS03395	COG0523	cobalamin synthesis protein
NBE99_RS03425	COG0842	Transport permease protein
NBE99_RS03425	COG1716	ATPase activity
NBE99_RS03425	COG1131	(ABC) transporter
NBE99_RS03435	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
NBE99_RS03450	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
NBE99_RS03465	COG0601	transmembrane transport
NBE99_RS03475	COG0629	single-stranded DNA binding
NBE99_RS03485	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
NBE99_RS03500	COG0837	glucose binding
NBE99_RS03505	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
NBE99_RS03515	COG1672	PFAM Archaeal ATPase
NBE99_RS03515	COG2319	Wd-40 repeat
NBE99_RS03530	COG1028	Short-chain dehydrogenase reductase Sdr
NBE99_RS03535	COG0525	valine-tRNA ligase activity
NBE99_RS03545	COG4451	ribulose bisphosphate carboxylase, small
NBE99_RS03555	COG1850	ribulose-bisphosphate carboxylase activity
NBE99_RS03570	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
NBE99_RS03585	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
NBE99_RS03590	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
NBE99_RS03615	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
NBE99_RS03620	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
NBE99_RS03625	COG2211	Major facilitator Superfamily
NBE99_RS03630	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
NBE99_RS03655	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
NBE99_RS03660	COG0457	Tetratricopeptide repeat
NBE99_RS03665	COG0589	response to stress
NBE99_RS03700	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
NBE99_RS03705	COG0114	fumarate hydratase activity
NBE99_RS03725	COG2852	Protein conserved in bacteria
NBE99_RS03745	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
NBE99_RS03755	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
NBE99_RS03770	COG0564	pseudouridine synthase activity
NBE99_RS03775	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
NBE99_RS03780	COG1357	PFAM Pentapeptide repeats (8 copies)
NBE99_RS03780	COG0515	serine threonine protein kinase
NBE99_RS03805	COG1175	transmembrane transport
NBE99_RS03810	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
NBE99_RS03815	COG0138	bifunctional purine biosynthesis protein purh
NBE99_RS03835	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
NBE99_RS03840	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
NBE99_RS03855	COG0714	Associated with various cellular activities
NBE99_RS03860	COG0196	riboflavin kinase activity
NBE99_RS03865	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
NBE99_RS03875	COG0540	Belongs to the ATCase OTCase family
NBE99_RS03880	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
NBE99_RS03885	COG1562	ergosterol biosynthetic process
NBE99_RS03890	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
NBE99_RS03890	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
NBE99_RS03905	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
NBE99_RS03915	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
NBE99_RS03925	COG1366	Belongs to the anti-sigma-factor antagonist family
NBE99_RS03930	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
NBE99_RS03940	COG1137	ATPase activity
NBE99_RS03970	COG0762	integral membrane protein
NBE99_RS03990	COG4783	chaperone-mediated protein folding
NBE99_RS03995	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
NBE99_RS04015	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
NBE99_RS04020	COG0730	response to heat
NBE99_RS04025	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
NBE99_RS04035	COG0277	FAD linked oxidase domain protein
NBE99_RS04045	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
NBE99_RS04050	COG3659	wide pore channel activity
NBE99_RS04060	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
NBE99_RS04060	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
NBE99_RS04070	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
NBE99_RS04075	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
NBE99_RS04085	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
NBE99_RS04090	COG0037	tRNA processing
NBE99_RS04095	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
NBE99_RS04105	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
NBE99_RS04110	COG5001	Diguanylate cyclase
NBE99_RS04115	COG0336	Belongs to the RNA methyltransferase TrmD family
NBE99_RS04140	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
NBE99_RS04145	COG0793	Belongs to the peptidase S41A family
NBE99_RS04150	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
NBE99_RS04160	COG2226	methyltransferase
NBE99_RS04165	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
NBE99_RS04165	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
NBE99_RS04170	COG1271	oxidase subunit
NBE99_RS04175	COG1294	oxidase, subunit
NBE99_RS04190	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
NBE99_RS04195	COG1215	transferase activity, transferring glycosyl groups
NBE99_RS04210	COG0653	protein targeting
NBE99_RS04220	COG0739	heme binding
NBE99_RS04225	COG1797	cobyrinic acid a,c-diamide synthase activity
NBE99_RS04235	COG1035	Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus
NBE99_RS04245	COG0003	Pfam Anion-transporting ATPase
NBE99_RS04250	COG4181	ATPase activity
NBE99_RS04260	COG0151	Belongs to the GarS family
NBE99_RS04280	COG2890	protein-(glutamine-N5) methyltransferase activity
NBE99_RS04290	COG0697	spore germination
NBE99_RS04295	COG0527	aspartate kinase activity
NBE99_RS04300	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
NBE99_RS04305	COG5001	Diguanylate cyclase
NBE99_RS04305	COG1716	ATPase activity
NBE99_RS04310	COG3385	transposase activity
NBE99_RS04315	COG5002	protein histidine kinase activity
NBE99_RS04325	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
NBE99_RS04330	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
NBE99_RS04335	COG0215	cysteine-tRNA ligase activity
NBE99_RS04340	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
NBE99_RS04345	COG2154	pterin-4-alpha-carbinolamine dehydratase
NBE99_RS04360	COG0681	Belongs to the peptidase S26 family
NBE99_RS04365	COG3001	Fructosamine kinase
NBE99_RS04375	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
NBE99_RS04385	COG0651	ATP synthesis coupled electron transport
NBE99_RS04430	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
NBE99_RS04435	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
NBE99_RS04440	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
NBE99_RS04445	COG0439	Biotin carboxylase
NBE99_RS04450	COG1166	arginine decarboxylase activity
NBE99_RS04465	COG0616	signal peptide processing
NBE99_RS04475	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
NBE99_RS04475	COG0517	IMP dehydrogenase activity
NBE99_RS04480	COG2843	Capsule synthesis protein
NBE99_RS04485	COG3385	transposase activity
NBE99_RS04495	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
NBE99_RS04500	COG4636	protein conserved in cyanobacteria
NBE99_RS04510	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
NBE99_RS04520	COG1215	transferase activity, transferring glycosyl groups
NBE99_RS04525	COG1215	transferase activity, transferring glycosyl groups
NBE99_RS04540	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
NBE99_RS04545	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
NBE99_RS04550	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
NBE99_RS04555	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
NBE99_RS04575	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
NBE99_RS04585	COG4372	Transposase
NBE99_RS04625	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
NBE99_RS04640	COG0860	N-Acetylmuramoyl-L-alanine amidase
NBE99_RS04645	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
NBE99_RS04645	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
NBE99_RS04650	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
NBE99_RS04665	COG1136	(ABC) transporter
NBE99_RS04685	COG0083	homoserine kinase activity
NBE99_RS04690	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
NBE99_RS04695	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
NBE99_RS04700	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
NBE99_RS04705	COG0019	diaminopimelate decarboxylase activity
NBE99_RS04715	COG0740	serine-type endopeptidase activity
NBE99_RS04720	COG1316	TRANSCRIPTIONal
NBE99_RS04725	COG0142	geranyltranstransferase activity
NBE99_RS04730	COG3842	ATPase activity
NBE99_RS04735	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
NBE99_RS04740	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
NBE99_RS04745	COG1742	UPF0060 membrane protein
NBE99_RS04755	COG0347	Belongs to the P(II) protein family
NBE99_RS04765	COG0322	excinuclease ABC activity
NBE99_RS04775	COG0051	transcription antitermination factor activity, RNA binding
NBE99_RS04780	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
NBE99_RS04785	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
NBE99_RS04790	COG0049	tRNA binding
NBE99_RS04795	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
NBE99_RS04800	COG1385	rRNA (uridine-N3-)-methyltransferase activity
NBE99_RS04810	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
NBE99_RS04820	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
NBE99_RS04825	COG3977	Valine--pyruvate aminotransferase
NBE99_RS04835	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
NBE99_RS04840	COG0792	nuclease activity
NBE99_RS04845	COG3264	Mechanosensitive ion channel
NBE99_RS04845	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
NBE99_RS04860	COG0443	Heat shock 70 kDa protein
NBE99_RS04865	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
NBE99_RS04900	COG1192	Involved in chromosome partitioning
NBE99_RS04905	COG0052	Belongs to the universal ribosomal protein uS2 family
NBE99_RS04910	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
NBE99_RS04915	COG0307	riboflavin synthase, alpha
NBE99_RS04925	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
NBE99_RS04930	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
NBE99_RS04935	COG0454	-acetyltransferase
NBE99_RS04945	COG0248	Ppx GppA phosphatase
NBE99_RS04950	COG0559	Belongs to the binding-protein-dependent transport system permease family
NBE99_RS04955	COG0509	glycine decarboxylation via glycine cleavage system
NBE99_RS04965	COG0242	peptide deformylase activity
NBE99_RS04985	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
NBE99_RS04990	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
NBE99_RS05000	COG3063	Type IV pilus biogenesis stability protein PilW
NBE99_RS05020	COG0815	Transfers the fatty acyl group on membrane lipoproteins
NBE99_RS05035	COG0277	FAD linked oxidase domain protein
NBE99_RS05040	COG0247	lactate metabolic process
NBE99_RS05055	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
NBE99_RS05060	COG5002	protein histidine kinase activity
NBE99_RS05070	COG0483	inositol monophosphate 1-phosphatase activity
NBE99_RS05075	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
NBE99_RS05110	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
NBE99_RS05130	COG0181	hydroxymethylbilane synthase activity
NBE99_RS05145	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
NBE99_RS05150	COG0750	zinc metalloprotease
NBE99_RS05155	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
NBE99_RS05165	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
NBE99_RS05180	COG1218	3'(2'),5'-bisphosphate nucleotidase
NBE99_RS05195	COG0772	Belongs to the SEDS family
NBE99_RS05205	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
NBE99_RS05210	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
NBE99_RS05215	COG0012	GTP binding
NBE99_RS05220	COG0033	Phosphoglucomutase
NBE99_RS05225	COG0420	3'-5' exonuclease activity
NBE99_RS05245	COG3385	transposase activity
NBE99_RS05250	COG3385	transposase activity
NBE99_RS05265	COG1234	tRNA 3'-trailer cleavage
NBE99_RS05275	COG0220	tRNA (guanine-N7-)-methyltransferase activity
NBE99_RS05285	COG0004	ammonium transporteR
NBE99_RS05295	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
NBE99_RS05315	COG0180	Tryptophanyl-tRNA synthetase
NBE99_RS05330	COG5001	Diguanylate cyclase
NBE99_RS05330	COG3300	MHYT domain
NBE99_RS05335	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
NBE99_RS05340	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
NBE99_RS05345	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
NBE99_RS05345	COG1116	anion transmembrane transporter activity
NBE99_RS05350	COG1116	anion transmembrane transporter activity
NBE99_RS05405	COG0515	serine threonine protein kinase
NBE99_RS05415	COG0850	regulation of cytokinetic process
NBE99_RS05420	COG2894	cell division
NBE99_RS05425	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
NBE99_RS05435	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
NBE99_RS05465	COG0857	belongs to the CobB CobQ family
NBE99_RS05480	COG0598	Magnesium transport protein CorA
NBE99_RS05485	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
NBE99_RS05490	COG2045	Belongs to the ComB family
NBE99_RS05505	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
NBE99_RS05505	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
NBE99_RS05510	COG2226	methyltransferase
NBE99_RS05515	COG3150	esterase
NBE99_RS05525	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
NBE99_RS05535	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
NBE99_RS05540	COG5398	heme oxygenase
NBE99_RS05565	COG1492	cobalamin metabolic process
NBE99_RS05575	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
NBE99_RS05580	COG0157	Belongs to the NadC ModD family
NBE99_RS05585	COG1178	ABC-type Fe3 transport system permease component
NBE99_RS05595	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
NBE99_RS05605	COG2326	polyphosphate kinase activity
NBE99_RS05610	COG2003	Belongs to the UPF0758 family
NBE99_RS05615	COG3659	wide pore channel activity
NBE99_RS05625	COG0357	Ribosomal RNA small subunit methyltransferase G
NBE99_RS05640	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
NBE99_RS05665	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
NBE99_RS05670	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
NBE99_RS05680	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
NBE99_RS05685	COG0316	Belongs to the HesB IscA family
NBE99_RS05690	COG1090	epimerase
NBE99_RS05700	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
NBE99_RS05715	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
NBE99_RS05730	COG0077	Prephenate dehydratase
NBE99_RS05735	COG0686	Belongs to the AlaDH PNT family
NBE99_RS05740	COG0575	Belongs to the CDS family
NBE99_RS05745	COG1595	DNA-templated transcription, initiation
NBE99_RS05755	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
NBE99_RS05785	COG1725	Transcriptional regulator
NBE99_RS05790	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
NBE99_RS05795	COG0483	inositol monophosphate 1-phosphatase activity
NBE99_RS05805	COG3385	transposase activity
NBE99_RS05815	COG3385	transposase activity
NBE99_RS05835	COG0405	Gamma-glutamyltransferase
NBE99_RS05840	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
NBE99_RS05845	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
NBE99_RS05865	COG1489	DNA binding
NBE99_RS05870	COG1773	rubredoxin
NBE99_RS05875	COG4447	cellulose binding
NBE99_RS05885	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
NBE99_RS05890	COG1842	Phage shock protein A
NBE99_RS05910	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
NBE99_RS05940	COG1543	Belongs to the glycosyl hydrolase 57 family
NBE99_RS05945	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
NBE99_RS05955	COG2308	Evidence 4 Homologs of previously reported genes of
NBE99_RS05960	COG0525	valine-tRNA ligase activity
NBE99_RS05965	COG0518	GMP synthase (glutamine-hydrolyzing) activity
NBE99_RS05965	COG0519	Catalyzes the synthesis of GMP from XMP
NBE99_RS05970	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
NBE99_RS05980	COG0739	heme binding
NBE99_RS05985	COG0237	dephospho-CoA kinase activity
NBE99_RS05990	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
NBE99_RS05995	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
NBE99_RS06000	COG1413	lyase activity
NBE99_RS06005	COG1413	lyase activity
NBE99_RS06010	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
NBE99_RS06015	COG0237	dephospho-CoA kinase activity
NBE99_RS06030	COG1573	uracil-dna glycosylase
NBE99_RS06045	COG2226	methyltransferase
NBE99_RS06055	COG0391	Required for morphogenesis under gluconeogenic growth conditions
NBE99_RS06070	COG0863	Belongs to the N(4) N(6)-methyltransferase family
NBE99_RS06075	COG0354	folic acid binding
NBE99_RS06080	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
NBE99_RS06085	COG0352	thiamine-phosphate diphosphorylase activity
NBE99_RS06110	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
NBE99_RS06125	COG0779	Required for maturation of 30S ribosomal subunits
NBE99_RS06130	COG0195	Participates in both transcription termination and antitermination
NBE99_RS06140	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
NBE99_RS06160	COG0800	Aldolase
NBE99_RS06165	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
NBE99_RS06175	COG1196	nuclear chromosome segregation
NBE99_RS06180	COG0492	ferredoxin-NADP+ reductase activity
NBE99_RS06200	COG4636	protein conserved in cyanobacteria
NBE99_RS06205	COG2217	Heavy metal translocating P-type atpase
NBE99_RS06230	COG0333	Belongs to the bacterial ribosomal protein bL32 family
NBE99_RS06235	COG0572	uridine kinase
NBE99_RS06245	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
NBE99_RS06255	COG3385	transposase activity
NBE99_RS06260	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
NBE99_RS06265	COG0719	Fe-S assembly protein
NBE99_RS06270	COG0396	ATPase activity
NBE99_RS06280	COG3693	PFAM glycoside hydrolase, family 10
NBE99_RS06285	COG1131	(ABC) transporter
NBE99_RS06295	COG0497	DNA recombination
NBE99_RS06305	COG0124	histidyl-tRNA synthetase
NBE99_RS06325	COG1612	heme a metabolic process
NBE99_RS06330	COG0109	protoheme IX farnesyltransferase activity
NBE99_RS06340	COG0300	oxidoreductase activity
NBE99_RS06360	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
NBE99_RS06370	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
NBE99_RS06370	COG1754	DNA topoisomerase type I activity
NBE99_RS06395	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
NBE99_RS06405	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
NBE99_RS06410	COG0557	exoribonuclease II activity
NBE99_RS06415	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
NBE99_RS06420	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
NBE99_RS06425	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
NBE99_RS06440	COG3906	Belongs to the UPF0473 family
NBE99_RS06445	COG1982	Orn Lys Arg decarboxylase major
NBE99_RS06470	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
NBE99_RS06480	COG3385	transposase activity
NBE99_RS06495	COG0473	3-isopropylmalate dehydrogenase activity
NBE99_RS06510	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
NBE99_RS06515	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
NBE99_RS06525	COG0515	serine threonine protein kinase
NBE99_RS06540	COG0438	transferase activity, transferring glycosyl groups
NBE99_RS06545	COG0438	transferase activity, transferring glycosyl groups
NBE99_RS06555	COG0174	glutamine synthetase
NBE99_RS06560	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
NBE99_RS06565	COG1959	2 iron, 2 sulfur cluster binding
NBE99_RS06570	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
NBE99_RS06575	COG1108	ABC-type Mn2 Zn2 transport systems permease components
NBE99_RS06580	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
NBE99_RS06585	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
NBE99_RS06600	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
NBE99_RS06610	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
NBE99_RS06615	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
NBE99_RS06655	COG0824	Thioesterase
NBE99_RS06670	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
NBE99_RS06675	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
NBE99_RS06695	COG2205	protein histidine kinase activity
NBE99_RS06700	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
NBE99_RS06710	COG2203	Gaf domain
NBE99_RS06710	COG3706	GGDEF domain
NBE99_RS06710	COG5001	Diguanylate cyclase
NBE99_RS06710	COG4251	negative regulation of phosphorylation
NBE99_RS06720	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
NBE99_RS06730	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
NBE99_RS06735	COG0436	Aminotransferase
NBE99_RS06765	COG0495	leucyl-tRNA aminoacylation
NBE99_RS06790	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
NBE99_RS06795	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
NBE99_RS06815	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
NBE99_RS06825	COG3118	belongs to the thioredoxin family
NBE99_RS06855	COG0714	Associated with various cellular activities
NBE99_RS06865	COG0058	SHG alpha-glucan phosphorylase activity
NBE99_RS06875	COG3932	Exopolysaccharide synthesis, ExoD
NBE99_RS06885	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
NBE99_RS06895	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
NBE99_RS06900	COG0539	negative regulation of cytoplasmic translation
NBE99_RS06905	COG1970	mechanosensitive ion channel activity
NBE99_RS06915	COG3158	transport of potassium into the cell
NBE99_RS06920	COG0436	Aminotransferase
NBE99_RS06925	COG0371	Dehydrogenase
NBE99_RS06935	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
NBE99_RS06935	COG2022	thiamine diphosphate biosynthetic process
NBE99_RS06945	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
NBE99_RS06950	COG0587	DNA-directed DNA polymerase activity
NBE99_RS06970	COG0267	Belongs to the bacterial ribosomal protein bL33 family
NBE99_RS06975	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
NBE99_RS06980	COG0803	Belongs to the bacterial solute-binding protein 9 family
NBE99_RS06985	COG1121	(ABC) transporter
NBE99_RS07000	COG0596	Alpha beta hydrolase
NBE99_RS07010	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
NBE99_RS07015	COG0587	DNA-directed DNA polymerase activity
NBE99_RS07040	COG0275	rRNA processing
NBE99_RS07050	COG0768	penicillin binding
NBE99_RS07095	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
NBE99_RS07100	COG0170	dolichyl monophosphate biosynthetic process
NBE99_RS07110	COG0583	DNA-binding transcription factor activity
NBE99_RS07120	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
NBE99_RS07130	COG0556	nucleotide-excision repair
NBE99_RS07135	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
NBE99_RS07140	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
NBE99_RS07145	COG3118	belongs to the thioredoxin family
NBE99_RS07150	COG4399	Belongs to the UPF0754 family
NBE99_RS07160	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
NBE99_RS07165	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
NBE99_RS07170	COG5505	Protein of unknown function (DUF819)
NBE99_RS07185	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
NBE99_RS07195	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
NBE99_RS07240	COG4279	zinc finger
NBE99_RS07245	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
NBE99_RS07250	COG1496	oxidoreductase activity
NBE99_RS07265	COG1657	PFAM Prenyltransferase squalene oxidase
NBE99_RS07270	COG4783	chaperone-mediated protein folding
NBE99_RS07285	COG0515	serine threonine protein kinase
NBE99_RS07285	COG1357	PFAM Pentapeptide repeats (8 copies)
NBE99_RS07290	COG0515	serine threonine protein kinase
NBE99_RS07290	COG3266	domain, Protein
NBE99_RS07300	COG1217	gtp-binding protein TYPA
NBE99_RS07345	COG0523	cobalamin synthesis protein
NBE99_RS07350	COG0469	pyruvate kinase activity
NBE99_RS07365	COG0135	phosphoribosylanthranilate isomerase activity
NBE99_RS07385	COG0589	response to stress
NBE99_RS07390	COG0126	phosphoglycerate kinase activity
NBE99_RS07395	COG0776	regulation of translation
NBE99_RS07400	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
NBE99_RS07405	COG0006	proline dipeptidase activity
NBE99_RS07415	COG0863	Belongs to the N(4) N(6)-methyltransferase family
NBE99_RS07430	COG0628	permease
NBE99_RS07440	COG0450	alkyl hydroperoxide reductase
NBE99_RS07445	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
NBE99_RS07450	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
NBE99_RS07465	COG0482	sulfurtransferase activity
NBE99_RS07470	COG0724	RNA recognition motif
NBE99_RS07475	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
NBE99_RS07480	COG2255	four-way junction helicase activity
NBE99_RS07495	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
NBE99_RS07545	COG0793	Belongs to the peptidase S41A family
NBE99_RS07555	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
NBE99_RS07565	COG0631	protein serine/threonine phosphatase activity
NBE99_RS07570	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
NBE99_RS07575	COG0477	Major facilitator Superfamily
NBE99_RS07580	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
NBE99_RS07590	COG2208	phosphoserine phosphatase activity
NBE99_RS07600	COG1381	Involved in DNA repair and RecF pathway recombination
NBE99_RS07610	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
NBE99_RS07615	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
NBE99_RS07625	COG0515	serine threonine protein kinase
NBE99_RS07625	COG2815	serine threonine protein kinase
NBE99_RS07640	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
NBE99_RS07655	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
NBE99_RS07660	COG0443	Heat shock 70 kDa protein
NBE99_RS07675	COG0582	viral genome integration into host DNA
NBE99_RS07685	COG3781	membrane
NBE99_RS07690	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
NBE99_RS07705	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
NBE99_RS07710	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
NBE99_RS07715	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
NBE99_RS07720	COG0745	RESPONSE REGULATOR receiver
NBE99_RS07725	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
NBE99_RS07730	COG1216	Glycosyl transferase, family 2
NBE99_RS07745	COG0456	acetyltransferase
NBE99_RS07755	COG1575	Belongs to the MenA family. Type 1 subfamily
NBE99_RS07770	COG1185	polyribonucleotide nucleotidyltransferase activity
NBE99_RS07775	COG0751	glycine-tRNA ligase activity
NBE99_RS07785	COG0516	GMP reductase activity
NBE99_RS07790	COG0791	NLP P60 protein
NBE99_RS07795	COG0047	phosphoribosylformylglycinamidine synthase activity
NBE99_RS07805	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
NBE99_RS07810	COG0330	HflC and HflK could
NBE99_RS07815	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
NBE99_RS07815	COG0546	phosphoglycolate phosphatase activity
NBE99_RS07830	COG1028	Short-chain dehydrogenase reductase Sdr
NBE99_RS07840	COG2304	oxidoreductase activity
NBE99_RS07845	COG0419	ATPase involved in DNA repair
NBE99_RS07870	COG0189	ligase activity
NBE99_RS07870	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
NBE99_RS07895	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
NBE99_RS07900	COG0581	inorganic phosphate transmembrane transporter activity
NBE99_RS07905	COG0573	inorganic phosphate transmembrane transporter activity
NBE99_RS07910	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
NBE99_RS07925	COG2302	S4 RNA-binding domain
NBE99_RS07935	COG0291	Belongs to the bacterial ribosomal protein bL35 family
NBE99_RS07940	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
NBE99_RS07945	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
NBE99_RS07955	COG1587	Uroporphyrinogen-III synthase
NBE99_RS07960	COG0739	heme binding
NBE99_RS07970	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
NBE99_RS07970	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
NBE99_RS07980	COG0443	Heat shock 70 kDa protein
NBE99_RS07985	COG0484	heat shock protein binding
NBE99_RS07995	COG2094	Belongs to the DNA glycosylase MPG family
NBE99_RS08000	COG0659	secondary active sulfate transmembrane transporter activity
NBE99_RS08060	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
NBE99_RS08075	COG1546	Belongs to the CinA family
NBE99_RS08075	COG1058	Belongs to the CinA family
NBE99_RS08080	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
NBE99_RS08085	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
NBE99_RS08115	COG2884	Cell division ATP-binding protein ftsE
NBE99_RS08120	COG2177	Part of the ABC transporter FtsEX involved in
NBE99_RS08125	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
NBE99_RS08130	COG0802	atpase or kinase
NBE99_RS08135	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
NBE99_RS08140	COG0475	glutathione-regulated potassium exporter activity
NBE99_RS08150	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
NBE99_RS08155	COG0515	serine threonine protein kinase
NBE99_RS08170	COG4172	Belongs to the ABC transporter superfamily
NBE99_RS08180	COG0772	Belongs to the SEDS family
NBE99_RS08185	COG0159	tryptophan synthase activity
NBE99_RS08195	COG5002	protein histidine kinase activity
NBE99_RS08200	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
NBE99_RS08205	COG1215	transferase activity, transferring glycosyl groups
NBE99_RS08210	COG3385	transposase activity
NBE99_RS08215	COG3385	transposase activity
NBE99_RS08220	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
NBE99_RS08225	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
NBE99_RS08230	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
NBE99_RS08255	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
NBE99_RS08260	COG1366	Belongs to the anti-sigma-factor antagonist family
NBE99_RS08270	COG0415	Belongs to the DNA photolyase family
NBE99_RS08275	COG0024	Methionine aminopeptidase
NBE99_RS08285	COG0113	porphobilinogen synthase activity
NBE99_RS08290	COG0431	NADPH-dependent FMN reductase
NBE99_RS08305	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
NBE99_RS08305	COG0438	transferase activity, transferring glycosyl groups
NBE99_RS08315	COG1012	belongs to the aldehyde dehydrogenase family
NBE99_RS08330	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
NBE99_RS08345	COG0569	domain protein
NBE99_RS08365	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
NBE99_RS08380	COG0681	Belongs to the peptidase S26 family
NBE99_RS08395	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
NBE99_RS08400	COG1834	amidinotransferase
NBE99_RS08405	COG0544	peptidyl-prolyl cis-trans isomerase activity
NBE99_RS08410	COG0740	serine-type endopeptidase activity
NBE99_RS08415	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
NBE99_RS08425	COG4221	oxidoreductase activity
NBE99_RS08440	COG2226	methyltransferase
NBE99_RS08445	COG0589	response to stress
NBE99_RS08460	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
NBE99_RS08465	COG2022	thiamine diphosphate biosynthetic process
NBE99_RS08465	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
NBE99_RS08475	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
NBE99_RS08480	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
NBE99_RS08480	COG0237	dephospho-CoA kinase activity
NBE99_RS08485	COG0745	RESPONSE REGULATOR receiver
NBE99_RS08510	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
NBE99_RS08515	COG1215	transferase activity, transferring glycosyl groups
NBE99_RS08525	COG0436	Aminotransferase
NBE99_RS08540	COG1940	carbohydrate kinase activity
NBE99_RS08545	COG1316	TRANSCRIPTIONal
NBE99_RS08550	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
NBE99_RS08560	COG3385	transposase activity
NBE99_RS08570	COG5002	protein histidine kinase activity
NBE99_RS08575	COG0728	peptidoglycan biosynthetic process
NBE99_RS08580	COG0592	DNA-directed DNA polymerase activity
NBE99_RS08590	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
NBE99_RS08600	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
NBE99_RS08625	COG1376	ErfK ybiS ycfS ynhG family protein
NBE99_RS08635	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
NBE99_RS08645	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
NBE99_RS08650	COG2252	PERMEase
NBE99_RS08680	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
NBE99_RS08685	COG2052	Domain of unknown function (DUF370)
NBE99_RS08700	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
NBE99_RS08705	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
NBE99_RS08715	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
NBE99_RS08740	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
NBE99_RS08745	COG1108	ABC-type Mn2 Zn2 transport systems permease components
NBE99_RS08750	COG1836	PFAM Integral membrane protein DUF92
NBE99_RS08770	COG1216	Glycosyl transferase, family 2
NBE99_RS08780	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
NBE99_RS08800	COG1162	GTPase activity
NBE99_RS08815	COG1253	flavin adenine dinucleotide binding
NBE99_RS08825	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
NBE99_RS08830	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
NBE99_RS08835	COG0831	urea catabolic process
NBE99_RS08840	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
NBE99_RS08845	COG2048	Heterodisulfide reductase, subunit B
NBE99_RS08850	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
NBE99_RS08865	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
NBE99_RS08870	COG1063	alcohol dehydrogenase
NBE99_RS08875	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
NBE99_RS08890	COG0149	triose-phosphate isomerase activity
NBE99_RS08900	COG1192	Involved in chromosome partitioning
NBE99_RS08905	COG1132	(ABC) transporter
NBE99_RS08945	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
NBE99_RS08950	COG0805	protein transport
NBE99_RS08955	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
NBE99_RS08965	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
NBE99_RS08980	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
NBE99_RS08985	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
NBE99_RS08990	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
NBE99_RS08995	COG4451	ribulose bisphosphate carboxylase, small
NBE99_RS08995	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
NBE99_RS09005	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
NBE99_RS09025	COG1077	Cell shape determining protein MreB Mrl
NBE99_RS09040	COG0741	lytic transglycosylase activity
NBE99_RS09050	COG1028	Short-chain dehydrogenase reductase Sdr
NBE99_RS09060	COG0436	Aminotransferase
NBE99_RS09065	COG0552	protein localization to endoplasmic reticulum
NBE99_RS09070	COG1218	3'(2'),5'-bisphosphate nucleotidase
NBE99_RS09080	COG5002	protein histidine kinase activity
NBE99_RS09085	COG3706	GGDEF domain
NBE99_RS09085	COG4251	negative regulation of phosphorylation
NBE99_RS09085	COG2203	Gaf domain
NBE99_RS09085	COG5001	Diguanylate cyclase
NBE99_RS09100	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
NBE99_RS09115	COG0596	Alpha beta hydrolase
NBE99_RS09140	COG1104	cysteine desulfurase activity
NBE99_RS09165	COG2239	Acts as a magnesium transporter
NBE99_RS09170	COG1285	pathogenesis
NBE99_RS09180	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
NBE99_RS09195	COG0612	Peptidase, M16
NBE99_RS09215	COG0133	tryptophan synthase activity
NBE99_RS09220	COG0017	Asparaginyl-tRNA synthetase
NBE99_RS09225	COG1193	negative regulation of DNA recombination
NBE99_RS09245	COG5001	Diguanylate cyclase
NBE99_RS09250	COG3385	transposase activity
NBE99_RS09260	COG3536	Protein conserved in bacteria
NBE99_RS09265	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
NBE99_RS09270	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
NBE99_RS09275	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
NBE99_RS09285	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
NBE99_RS09290	COG0227	Belongs to the bacterial ribosomal protein bL28 family
NBE99_RS09345	COG0542	response to heat
NBE99_RS09350	COG1192	Involved in chromosome partitioning
NBE99_RS09370	COG0745	RESPONSE REGULATOR receiver
NBE99_RS09390	COG0528	UMP kinase activity
NBE99_RS09395	COG0233	cytoplasmic translational termination
NBE99_RS09405	COG2385	sporulation resulting in formation of a cellular spore
NBE99_RS09415	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
NBE99_RS09430	COG0284	orotidine-5'-phosphate decarboxylase activity
NBE99_RS09455	COG4636	protein conserved in cyanobacteria
NBE99_RS09465	COG2197	response regulator
NBE99_RS09470	COG3659	wide pore channel activity
NBE99_RS09475	COG0793	Belongs to the peptidase S41A family
NBE99_RS09480	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
NBE99_RS09500	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
NBE99_RS09505	COG1840	ABC-type Fe3 transport system, periplasmic component
NBE99_RS09525	COG1566	PFAM secretion protein HlyD family protein
NBE99_RS09530	COG0470	DNA polymerase III
NBE99_RS09535	COG0617	tRNA 3'-terminal CCA addition
NBE99_RS09535	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
NBE99_RS09535	COG0517	IMP dehydrogenase activity
NBE99_RS09550	COG1181	Belongs to the D-alanine--D-alanine ligase family
NBE99_RS09560	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
NBE99_RS09575	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
NBE99_RS09580	COG0312	modulator of DNA gyrase
NBE99_RS09585	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
NBE99_RS09590	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
NBE99_RS09600	COG0632	four-way junction helicase activity
NBE99_RS09610	COG3385	transposase activity
NBE99_RS09635	COG0445	tRNA wobble uridine modification
NBE99_RS09640	COG0829	nickel cation binding
NBE99_RS09655	COG0475	glutathione-regulated potassium exporter activity
NBE99_RS09655	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
NBE99_RS09660	COG3409	Peptidoglycan-binding domain 1 protein
NBE99_RS09660	COG3429	Glucose-6-phosphate dehydrogenase subunit
NBE99_RS09665	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
NBE99_RS09670	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
NBE99_RS09705	COG2172	sigma factor antagonist activity
NBE99_RS09715	COG4251	negative regulation of phosphorylation
NBE99_RS09735	COG1132	(ABC) transporter
NBE99_RS09750	COG0693	protein deglycase activity
NBE99_RS09760	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
NBE99_RS09775	COG1086	Polysaccharide biosynthesis protein
NBE99_RS09800	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
NBE99_RS09805	COG0438	transferase activity, transferring glycosyl groups
NBE99_RS09810	COG0123	including yeast histone deacetylase and acetoin utilization protein
NBE99_RS09815	COG1083	cytidylyl-transferase
NBE99_RS09820	COG3980	spore coat polysaccharide biosynthesis protein
NBE99_RS09825	COG2089	acid synthase
NBE99_RS09850	COG2198	Histidine kinase
NBE99_RS09850	COG0784	Response regulator, receiver
NBE99_RS09850	COG0643	Histidine kinase
NBE99_RS09855	COG2203	Gaf domain
NBE99_RS09855	COG0840	transmembrane signaling receptor activity
NBE99_RS09870	COG0784	Response regulator, receiver
NBE99_RS09885	COG3659	wide pore channel activity
NBE99_RS09895	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
NBE99_RS09900	COG1028	Short-chain dehydrogenase reductase Sdr
NBE99_RS09905	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
NBE99_RS09910	COG1132	(ABC) transporter
NBE99_RS09915	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
NBE99_RS09920	COG0167	dihydroorotate dehydrogenase activity
NBE99_RS09930	COG1122	ATPase activity
NBE99_RS09935	COG0438	transferase activity, transferring glycosyl groups
NBE99_RS09945	COG0515	serine threonine protein kinase
NBE99_RS09950	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
NBE99_RS09950	COG0574	Belongs to the PEP-utilizing enzyme family
NBE99_RS09955	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
NBE99_RS09965	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
NBE99_RS09970	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
NBE99_RS09985	COG0484	heat shock protein binding
NBE99_RS09990	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
NBE99_RS09995	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
NBE99_RS10000	COG0434	BtpA family
NBE99_RS10005	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
NBE99_RS10020	COG0217	transcriptional regulatory protein
NBE99_RS10025	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
NBE99_RS10025	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
NBE99_RS10035	COG4948	Mandelate Racemase Muconate Lactonizing
NBE99_RS10045	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
NBE99_RS10055	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
NBE99_RS10055	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
NBE99_RS10065	COG0457	Tetratricopeptide repeat
NBE99_RS10065	COG0463	Glycosyl transferase, family 2
NBE99_RS10070	COG0812	UDP-N-acetylmuramate dehydrogenase activity
NBE99_RS10075	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
NBE99_RS10090	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
NBE99_RS10115	COG1857	crispr-associated protein
NBE99_RS10125	COG1203	CRISPR-associated helicase, Cas3
NBE99_RS10135	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
NBE99_RS10140	COG1468	defense response to virus
NBE99_RS10140	COG1518	maintenance of DNA repeat elements
NBE99_RS10160	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
NBE99_RS10165	COG0066	3-isopropylmalate dehydratase activity
NBE99_RS10195	COG3385	transposase activity
NBE99_RS10200	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
NBE99_RS10210	COG1459	type II secretion system
NBE99_RS10215	COG0484	heat shock protein binding
NBE99_RS10240	COG4802	Ferredoxin thioredoxin reductase catalytic beta chain
NBE99_RS10255	COG0254	rRNA binding
NBE99_RS10260	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
NBE99_RS10265	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
NBE99_RS10270	COG0101	tRNA pseudouridine synthase activity
NBE99_RS10275	COG0203	ribosomal protein L17
NBE99_RS10280	COG0202	RNA polymerase activity
NBE99_RS10285	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
NBE99_RS10290	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
NBE99_RS10295	COG0257	Belongs to the bacterial ribosomal protein bL36 family
NBE99_RS10300	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
NBE99_RS10305	COG0563	adenylate kinase activity
NBE99_RS10310	COG0201	protein transport
NBE99_RS10315	COG0200	Binds to the 23S rRNA
NBE99_RS10320	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
NBE99_RS10325	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
NBE99_RS10330	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
NBE99_RS10335	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
NBE99_RS10340	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
NBE99_RS10345	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
NBE99_RS10350	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
NBE99_RS10355	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
NBE99_RS10360	COG0255	Belongs to the universal ribosomal protein uL29 family
NBE99_RS10365	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
NBE99_RS10370	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
NBE99_RS10375	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
NBE99_RS10380	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
NBE99_RS10385	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
NBE99_RS10390	COG0089	rRNA binding
NBE99_RS10395	COG0088	Forms part of the polypeptide exit tunnel
NBE99_RS10400	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
NBE99_RS10405	COG0343	queuine tRNA-ribosyltransferase activity
NBE99_RS10420	COG3385	transposase activity
NBE99_RS10440	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
NBE99_RS10455	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
NBE99_RS10460	COG0628	permease
NBE99_RS10485	COG3385	transposase activity
NBE99_RS10495	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
NBE99_RS10500	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
NBE99_RS10505	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
NBE99_RS10510	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
NBE99_RS10520	COG2022	thiamine diphosphate biosynthetic process
NBE99_RS10545	COG0420	3'-5' exonuclease activity
NBE99_RS10555	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
NBE99_RS10560	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
NBE99_RS10565	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
NBE99_RS10570	COG0848	biopolymer transport protein
NBE99_RS10575	COG0194	GDP metabolic process
NBE99_RS10595	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
NBE99_RS10605	COG0804	urea catabolic process
NBE99_RS10630	COG0071	Belongs to the small heat shock protein (HSP20) family
NBE99_RS10635	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
NBE99_RS10640	COG0271	Belongs to the BolA IbaG family
NBE99_RS10645	COG2205	protein histidine kinase activity
NBE99_RS10645	COG5002	protein histidine kinase activity
NBE99_RS10645	COG0784	Response regulator, receiver
NBE99_RS10655	COG1160	GTP binding
NBE99_RS10670	COG0440	acetolactate synthase activity
NBE99_RS10680	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
NBE99_RS10695	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
NBE99_RS10705	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
NBE99_RS10720	COG1116	anion transmembrane transporter activity
NBE99_RS10735	COG0602	queuosine metabolic process
NBE99_RS10750	COG0237	dephospho-CoA kinase activity
NBE99_RS10755	COG2205	protein histidine kinase activity
NBE99_RS10780	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
NBE99_RS10785	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
NBE99_RS10795	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
NBE99_RS10800	COG0189	ligase activity
NBE99_RS10805	COG2189	Belongs to the N(4) N(6)-methyltransferase family
NBE99_RS10825	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
NBE99_RS10830	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
NBE99_RS10835	COG0735	belongs to the Fur family
NBE99_RS10845	COG1619	proteins homologs of microcin C7 resistance protein MccF
NBE99_RS10850	COG1007	ATP synthesis coupled electron transport
NBE99_RS10860	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
NBE99_RS10865	COG0318	PFAM AMP-dependent synthetase and ligase
NBE99_RS10865	COG0204	Acyl-transferase
NBE99_RS10870	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
NBE99_RS10875	COG0228	four-way junction DNA binding
NBE99_RS10885	COG0828	Belongs to the bacterial ribosomal protein bS21 family
NBE99_RS10890	COG1702	phosphate starvation-inducible protein PhoH
NBE99_RS10905	COG3385	transposase activity
NBE99_RS10925	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
NBE99_RS10935	COG2205	protein histidine kinase activity
NBE99_RS10975	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
NBE99_RS10985	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
NBE99_RS11000	COG2211	Major facilitator Superfamily
NBE99_RS11005	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
NBE99_RS11010	COG2954	triphosphatase activity
NBE99_RS11015	COG1473	amidohydrolase
NBE99_RS11040	COG4956	integral membrane protein (PIN domain superfamily)
NBE99_RS11050	COG2006	4fe-4S ferredoxin, iron-sulfur binding domain protein
NBE99_RS11055	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
NBE99_RS11060	COG0316	Belongs to the HesB IscA family
NBE99_RS11090	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
NBE99_RS11105	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
NBE99_RS11110	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
NBE99_RS11140	COG1045	serine acetyltransferase
NBE99_RS11145	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
NBE99_RS11170	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
NBE99_RS11175	COG0416	fatty acid biosynthetic process
NBE99_RS11180	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
NBE99_RS11205	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
NBE99_RS11210	COG0772	Belongs to the SEDS family
NBE99_RS11240	COG3852	Histidine kinase
NBE99_RS11245	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
NBE99_RS11250	COG0321	lipoyl(octanoyl) transferase activity
NBE99_RS11255	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
NBE99_RS11265	COG3264	Mechanosensitive ion channel
NBE99_RS11265	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
NBE99_RS11285	COG0018	arginyl-trna synthetase
NBE99_RS11295	COG0717	Belongs to the dCTP deaminase family
NBE99_RS11300	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
NBE99_RS11315	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
NBE99_RS11320	COG0803	Belongs to the bacterial solute-binding protein 9 family
NBE99_RS11325	COG1121	(ABC) transporter
NBE99_RS11330	COG1899	peptidyl-lysine modification to peptidyl-hypusine
NBE99_RS11340	COG2217	Heavy metal translocating P-type atpase
NBE99_RS11350	COG0678	peroxiredoxin activity
NBE99_RS11350	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
NBE99_RS11370	COG3118	belongs to the thioredoxin family
NBE99_RS11380	COG0747	negative chemotaxis
NBE99_RS11385	COG3956	TIGRFAM MazG family protein
NBE99_RS11390	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
NBE99_RS11420	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
NBE99_RS11430	COG0514	ATP-dependent DNA helicase (RecQ)
NBE99_RS11465	COG1666	GTP binding
NBE99_RS11475	COG0443	Heat shock 70 kDa protein
NBE99_RS11480	COG0484	heat shock protein binding
NBE99_RS11495	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
NBE99_RS11510	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
NBE99_RS11515	COG2223	nitrite transmembrane transporter activity
NBE99_RS11520	COG0058	SHG alpha-glucan phosphorylase activity
NBE99_RS11530	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
NBE99_RS11545	COG0442	prolyl-tRNA aminoacylation
NBE99_RS11555	COG0697	spore germination
NBE99_RS11560	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
NBE99_RS11575	COG0504	CTP synthase activity
NBE99_RS11585	COG0515	serine threonine protein kinase
NBE99_RS11585	COG1357	PFAM Pentapeptide repeats (8 copies)
NBE99_RS11590	COG0583	DNA-binding transcription factor activity
NBE99_RS11595	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
NBE99_RS11615	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
NBE99_RS11630	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
NBE99_RS11635	COG5002	protein histidine kinase activity
NBE99_RS11640	COG1799	cell septum assembly
NBE99_RS11645	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
NBE99_RS11655	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
NBE99_RS11660	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
NBE99_RS11670	COG0318	PFAM AMP-dependent synthetase and ligase
NBE99_RS11675	COG0799	negative regulation of ribosome biogenesis
NBE99_RS11680	COG3596	GTP binding
NBE99_RS11685	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
NBE99_RS11690	COG0745	RESPONSE REGULATOR receiver
NBE99_RS11695	COG5002	protein histidine kinase activity
NBE99_RS11705	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
NBE99_RS11710	COG0588	phosphoglycerate mutase activity
NBE99_RS11725	COG0788	formyltetrahydrofolate deformylase activity
NBE99_RS11730	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
NBE99_RS11735	COG0459	protein refolding
NBE99_RS11740	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
NBE99_RS11745	COG0395	ABC-type sugar transport system, permease component
NBE99_RS11750	COG0004	ammonium transporteR
NBE99_RS11760	COG0285	dihydrofolate synthase activity
NBE99_RS11770	COG0735	belongs to the Fur family
NBE99_RS11785	COG2205	protein histidine kinase activity
NBE99_RS11820	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
NBE99_RS11825	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
NBE99_RS11830	COG0022	dehydrogenase e1 component
NBE99_RS11830	COG0508	dehydrogenase complex catalyzes the overall conversion of
NBE99_RS11840	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
NBE99_RS11845	COG0625	glutathione transferase activity
NBE99_RS11855	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
NBE99_RS11855	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
NBE99_RS11865	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
NBE99_RS11870	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
NBE99_RS11875	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
NBE99_RS11880	COG1132	(ABC) transporter
NBE99_RS11885	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
NBE99_RS11895	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
NBE99_RS11905	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
NBE99_RS11910	COG1012	belongs to the aldehyde dehydrogenase family
NBE99_RS11915	COG4178	(ABC) transporter
NBE99_RS11925	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
NBE99_RS11930	COG1012	belongs to the aldehyde dehydrogenase family
NBE99_RS11930	COG1454	alcohol dehydrogenase
NBE99_RS11935	COG0095	Lipoate-protein ligase
NBE99_RS11950	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
NBE99_RS11960	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
NBE99_RS11960	COG0140	phosphoribosyl-ATP diphosphatase activity
NBE99_RS11980	COG1131	(ABC) transporter
NBE99_RS11980	COG1716	ATPase activity
NBE99_RS11980	COG0842	Transport permease protein
NBE99_RS11985	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
NBE99_RS11985	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
NBE99_RS11990	COG0612	Peptidase, M16
NBE99_RS11995	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
NBE99_RS12025	COG0156	8-amino-7-oxononanoate synthase activity
NBE99_RS12030	COG0745	RESPONSE REGULATOR receiver
NBE99_RS12035	COG1716	ATPase activity
NBE99_RS12035	COG1131	(ABC) transporter
NBE99_RS12035	COG0842	Transport permease protein
NBE99_RS12045	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
NBE99_RS12055	COG1357	PFAM Pentapeptide repeats (8 copies)
NBE99_RS12055	COG0515	serine threonine protein kinase
NBE99_RS12075	COG0704	Plays a role in the regulation of phosphate uptake
NBE99_RS12090	COG0358	DNA primase activity
NBE99_RS12095	COG0205	6-phosphofructokinase activity
NBE99_RS12100	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
NBE99_RS12105	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
NBE99_RS12120	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
NBE99_RS12125	COG5322	oxidoreductase activity
NBE99_RS12130	COG0825	malonyl-CoA metabolic process
NBE99_RS12135	COG0300	oxidoreductase activity
NBE99_RS12140	COG0302	gtp cyclohydrolase
NBE99_RS12165	COG1994	Peptidase M50
NBE99_RS12165	COG0517	IMP dehydrogenase activity
NBE99_RS12180	COG0335	large ribosomal subunit rRNA binding
NBE99_RS12185	COG0424	maF-like protein
NBE99_RS12190	COG1022	Amp-dependent synthetase and ligase
NBE99_RS12205	COG1122	ATPase activity
NBE99_RS12215	COG0174	glutamine synthetase
NBE99_RS12230	COG0028	Belongs to the TPP enzyme family
NBE99_RS12235	COG0511	ligase activity, forming carbon-carbon bonds
NBE99_RS12240	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
NBE99_RS12245	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
NBE99_RS12260	COG1070	Carbohydrate kinase
NBE99_RS12265	COG1160	GTP binding
NBE99_RS12280	COG0649	NAD binding
NBE99_RS12285	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
NBE99_RS12295	COG2010	Cytochrome c
NBE99_RS12300	COG2010	Cytochrome c
NBE99_RS12315	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
NBE99_RS12325	COG0360	Binds together with S18 to 16S ribosomal RNA
NBE99_RS12330	COG0179	Fumarylacetoacetate (FAA) hydrolase
NBE99_RS12345	COG0484	heat shock protein binding
NBE99_RS12355	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
NBE99_RS12355	COG0758	DNA mediated transformation
NBE99_RS12360	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
NBE99_RS12365	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
NBE99_RS12380	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
NBE99_RS12390	COG3063	Type IV pilus biogenesis stability protein PilW
NBE99_RS12395	COG0412	Dienelactone hydrolase
NBE99_RS12405	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
NBE99_RS12420	COG0310	cobalt ion transport
NBE99_RS12440	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
NBE99_RS12440	COG1240	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
NBE99_RS12445	COG0459	protein refolding
NBE99_RS12450	COG2340	Cysteine-rich secretory protein family
NBE99_RS12465	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
NBE99_RS12475	COG0793	Belongs to the peptidase S41A family
NBE99_RS12480	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
NBE99_RS12485	COG0644	oxidoreductase
NBE99_RS12490	COG1304	FMN binding
NBE99_RS12500	COG0121	glutamine amidotransferase
NBE99_RS12520	COG0314	molybdopterin synthase activity
NBE99_RS12530	COG0746	molybdenum cofactor guanylyltransferase activity
NBE99_RS12530	COG0315	cyclic pyranopterin monophosphate synthase activity
NBE99_RS12535	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
NBE99_RS12540	COG0303	'Molybdopterin
NBE99_RS12545	COG0830	nickel cation binding
NBE99_RS12550	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
NBE99_RS12555	COG0784	Response regulator, receiver
NBE99_RS12555	COG2205	protein histidine kinase activity
NBE99_RS12560	COG0070	glutamate synthase
NBE99_RS12560	COG0069	glutamate synthase activity
NBE99_RS12560	COG0067	glutamate synthase
NBE99_RS12565	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
NBE99_RS12570	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
NBE99_RS12585	COG0426	domain, Protein
NBE99_RS12585	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
NBE99_RS12595	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
NBE99_RS12600	COG2027	D-alanyl-D-alanine carboxypeptidase
NBE99_RS12610	COG1053	succinate dehydrogenase
NBE99_RS12625	COG0395	ABC-type sugar transport system, permease component
NBE99_RS12630	COG1136	(ABC) transporter
NBE99_RS12630	COG0577	efflux transmembrane transporter activity
NBE99_RS12635	COG0193	aminoacyl-tRNA hydrolase activity
NBE99_RS12640	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
NBE99_RS12660	COG0542	response to heat
NBE99_RS12675	COG3385	transposase activity
NBE99_RS12720	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
NBE99_RS12750	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
NBE99_RS12755	COG0601	transmembrane transport
NBE99_RS12765	COG0463	Glycosyl transferase, family 2
NBE99_RS12770	COG3385	transposase activity
NBE99_RS12775	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
NBE99_RS12780	COG1615	UPF0182 protein
NBE99_RS12785	COG0367	asparagine synthase
NBE99_RS12800	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
NBE99_RS12820	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
NBE99_RS12825	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
NBE99_RS12835	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
NBE99_RS12840	COG0583	DNA-binding transcription factor activity
NBE99_RS12845	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
NBE99_RS12860	COG0243	molybdopterin cofactor binding
NBE99_RS12865	COG1116	anion transmembrane transporter activity
NBE99_RS12870	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
NBE99_RS12870	COG1116	anion transmembrane transporter activity
NBE99_RS12875	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
NBE99_RS12880	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
NBE99_RS12885	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
NBE99_RS12890	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
NBE99_RS12900	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
NBE99_RS12905	COG0372	Belongs to the citrate synthase family
NBE99_RS12910	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
NBE99_RS12915	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
NBE99_RS12915	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
NBE99_RS12920	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
NBE99_RS12930	COG0469	pyruvate kinase activity
NBE99_RS12975	COG3385	transposase activity
NBE99_RS13000	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
NBE99_RS13005	COG1555	photosystem II stabilization
NBE99_RS13025	COG0359	binds to the 23S rRNA
NBE99_RS13030	COG0305	Participates in initiation and elongation during chromosome replication
NBE99_RS13030	COG1372	Participates in initiation and elongation during chromosome replication
NBE99_RS13030	COG0305	Participates in initiation and elongation during chromosome replication
NBE99_RS13030	COG1372	Participates in initiation and elongation during chromosome replication
NBE99_RS13035	COG4572	Cation transport regulator
NBE99_RS13045	COG0519	Catalyzes the synthesis of GMP from XMP
NBE99_RS13045	COG0518	GMP synthase (glutamine-hydrolyzing) activity
NBE99_RS13050	COG0489	protein tyrosine kinase activity
NBE99_RS13055	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
NBE99_RS13060	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
NBE99_RS13070	COG0745	RESPONSE REGULATOR receiver
NBE99_RS13080	COG0820	rRNA (adenine-C2-)-methyltransferase activity
NBE99_RS13085	COG2205	protein histidine kinase activity
NBE99_RS13090	COG0463	Glycosyl transferase, family 2
NBE99_RS13090	COG0457	Tetratricopeptide repeat
NBE99_RS13100	COG2010	Cytochrome c
NBE99_RS13110	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
NBE99_RS13125	COG0745	RESPONSE REGULATOR receiver
NBE99_RS13135	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
NBE99_RS13145	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
NBE99_RS13170	COG1530	ribonuclease E activity
NBE99_RS13175	COG2066	Belongs to the glutaminase family
NBE99_RS13185	COG0706	membrane insertase activity
NBE99_RS13200	COG0230	Belongs to the bacterial ribosomal protein bL34 family