locus-tag	class	description
THEMA_RS00005	ENOG4105CI4	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity)
THEMA_RS00010	ENOG4105CZ1	Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity)
THEMA_RS00025	ENOG4105DR1	Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity)
THEMA_RS00045	ENOG4105C8Q	Methyl-accepting chemotaxis
THEMA_RS00050	ENOG4105CJ3	phosphate transporter
THEMA_RS00060	ENOG4108UH2	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
THEMA_RS00065	ENOG41080JC	Protein of unknown function DUF47
THEMA_RS00070	ENOG4105DXN	mazG family
THEMA_RS00080	ENOG4105C35	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity)
THEMA_RS00085	ENOG4105D19	Role in flagellar biosynthesis (By similarity)
THEMA_RS00090	ENOG4105D00	flagellar biosynthetic protein flhB
THEMA_RS00095	ENOG4105D7B	Flagellar biosynthesis protein flha
THEMA_RS00100	ENOG4105FZW	flagellar biosynthesis regulator FlhF
THEMA_RS00115	ENOG4107PHP	CheC --inhibitor of MCP methylation
THEMA_RS00120	ENOG4108Z4W	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis (By similarity)
THEMA_RS00125	ENOG4105DN4	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
THEMA_RS00150	ENOG4105MCT	stage V sporulation protein S
THEMA_RS00155	ENOG4105F0Z	galactose-1-phosphate uridylyltransferase
THEMA_RS00160	ENOG4105CXW	Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity)
THEMA_RS00170	ENOG4105DWR	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity)
THEMA_RS00175	ENOG4105CJW	magnesium transporter
THEMA_RS00180	ENOG4105C4E	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity)
THEMA_RS00185	ENOG4105DZP	Membrane-associated zinc metalloprotease
THEMA_RS00190	ENOG4105CEA	Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity)
THEMA_RS00200	ENOG4105K85	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity)
THEMA_RS00205	ENOG4105BZ4	penicillin-binding protein
THEMA_RS00220	ENOG4105CGM	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity)
THEMA_RS00230	ENOG4105CVG	Homoserine O-transsuccinylase
THEMA_RS00235	ENOG4105D9Q	decarboxylase (Beta subunit)
THEMA_RS00245	ENOG4105DI2	Pyruvate flavodoxin ferredoxin oxidoreductase domain protein
THEMA_RS00250	ENOG4105C70	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity)
THEMA_RS00270	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
THEMA_RS00275	ENOG4105CGJ	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity)
THEMA_RS00285	ENOG4105CJN	penicillin-binding protein
THEMA_RS00295	ENOG4108JU3	Alkyl hydroperoxide reductase
THEMA_RS00315	ENOG4105IES	Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity)
THEMA_RS00320	ENOG4105K9Q	Binds to the 23S rRNA (By similarity)
THEMA_RS00325	ENOG4107V9E	glucose-1-phosphate thymidylyltransferase
THEMA_RS00330	ENOG4107VRQ	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
THEMA_RS00335	ENOG4107QN8	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
THEMA_RS00340	ENOG4107Z7W	Preprotein translocase YajC subunit
THEMA_RS00350	ENOG4105DTN	riboflavin biosynthesis protein ribF
THEMA_RS00355	ENOG4105D0T	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity)
THEMA_RS00360	ENOG41084NJ	Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity)
THEMA_RS00365	ENOG4108HU6	Metal dependent phosphohydrolase
THEMA_RS00370	ENOG4105BZU	Histidine kinase
THEMA_RS00375	ENOG4105EK0	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
THEMA_RS00385	ENOG4105CI8	Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity)
THEMA_RS00390	ENOG41085Z1	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
THEMA_RS00395	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
THEMA_RS00400	ENOG4105CQW	ribosome biogenesis GTPase YqeH
THEMA_RS00405	ENOG4105CWT	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity)
THEMA_RS00410	ENOG4105KG3	cytidine deaminase
THEMA_RS00415	ENOG4108JU5	Magnesium and cobalt efflux protein
THEMA_RS00420	ENOG41082VF	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity)
THEMA_RS00425	ENOG4105CCS	Glutamate formiminotransferase
THEMA_RS00430	ENOG4107YTP	response regulator receiver protein
THEMA_RS00445	ENOG4105CNI	cell division protein FtsW
THEMA_RS00455	ENOG4107QHF	type ii secretion system protein e
THEMA_RS00460	ENOG4105CDK	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity)
THEMA_RS00465	ENOG4105CIT	This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity)
THEMA_RS00475	ENOG4105C7D	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
THEMA_RS00485	ENOG4107Z5F	Aminotransferase class IV
THEMA_RS00490	ENOG4105CIW	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity)
THEMA_RS00500	ENOG4105DE4	1-phosphofructokinase
THEMA_RS00505	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
THEMA_RS00515	ENOG4105CM1	Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
THEMA_RS00530	ENOG4105C6A	phenylalanyl-tRNA synthetase (beta subunit)
THEMA_RS00545	ENOG4107QW4	alcohol dehydrogenase
THEMA_RS00555	ENOG4108UHC	Glycosyl transferase, wecb taga cpsf family
THEMA_RS00575	ENOG4105UQX	Mate efflux family protein
THEMA_RS00580	ENOG4105CE4	GlcNAc 6-P deacetylase
THEMA_RS00585	ENOG4105C46	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity)
THEMA_RS00590	ENOG4105DRS	transport system, permease
THEMA_RS00610	ENOG4105E2R	ROK family
THEMA_RS00615	ENOG4105D3R	alkyl hydroperoxide reductase
THEMA_RS00625	ENOG4105ESV	Glycosyl transferase, family 4
THEMA_RS00630	ENOG4107RU2	Histidinol phosphate phosphatase, HisJ family
THEMA_RS00635	ENOG4105C8D	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity)
THEMA_RS00640	ENOG4105C0Q	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity)
THEMA_RS00645	ENOG4108YXN	Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity)
THEMA_RS00650	ENOG4105EA8	2-Nitropropane dioxygenase
THEMA_RS00655	ENOG4105VKD	bioY protein
THEMA_RS00665	ENOG4108N5B	2-phosphosulfolactate phosphatase
THEMA_RS00685	ENOG4105CJ1	ABC, transporter
THEMA_RS00695	ENOG410816Z	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity)
THEMA_RS00700	ENOG4107ZCS	Phosphomethylpyrimidine kinase
THEMA_RS00710	ENOG4105CBF	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity)
THEMA_RS00715	ENOG4105IQJ	Involved in biosynthesis of the thiamine precursor thiazole (By similarity)
THEMA_RS00775	ENOG4107QHU	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity)
THEMA_RS00785	ENOG41061AI	Protein of unknown function (DUF2905)
THEMA_RS00790	ENOG4105MA4	psp1 domain protein
THEMA_RS00795	ENOG4107QRG	dna polymerase iii
THEMA_RS00800	ENOG4105CBM	Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity)
THEMA_RS00810	ENOG4105C9W	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity)
THEMA_RS00815	ENOG4105C9C	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity)
THEMA_RS00825	ENOG4105CJ1	ABC, transporter
THEMA_RS00835	ENOG4105K8R	UPF0145 protein
THEMA_RS00840	ENOG4105CE9	30S ribosomal protein S2
THEMA_RS00865	ENOG4107TVC	Glycosyl transferase, family 2
THEMA_RS00875	ENOG4105CNW	domain protein
THEMA_RS00885	ENOG4107UA9	Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) (By similarity)
THEMA_RS00890	ENOG4107V4V	glycoside hydrolase family 4
THEMA_RS00900	ENOG4105DBI	uridine monophosphokinase
THEMA_RS00915	ENOG4105E26	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity)
THEMA_RS00920	ENOG4105CN1	protease
THEMA_RS00935	ENOG4105BZF	Glycosyl transferase (Group 1
THEMA_RS00945	ENOG4107S1Q	Phosphatase
THEMA_RS00955	ENOG4105C22	threonyL-tRNA synthetase
THEMA_RS00960	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
THEMA_RS00975	ENOG4105DG6	mannose-6-phosphate isomerase
THEMA_RS00985	ENOG4107QXI	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs (By similarity)
THEMA_RS01000	ENOG4105WPN	DNA integration recombination invertion protein
THEMA_RS01005	ENOG4108YYA	Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity)
THEMA_RS01010	ENOG4105CWR	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity)
THEMA_RS01025	ENOG4105CMS	peptidase U62, modulator of DNA gyrase
THEMA_RS01030	ENOG4105D1U	peptidase U62 modulator of DNA gyrase
THEMA_RS01050	ENOG4105C40	3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity)
THEMA_RS01055	ENOG4105CZ5	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity)
THEMA_RS01060	ENOG4105C65	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity)
THEMA_RS01065	ENOG4105C8N	cysteinyl-tRNA synthetase
THEMA_RS01070	ENOG4105YFD	chemotaxis, protein
THEMA_RS01075	ENOG4105PV1	biotin lipoyl attachment domaiN-containing protein
THEMA_RS01085	ENOG4105D8K	carboxyl transferase
THEMA_RS01120	ENOG4105CU0	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity)
THEMA_RS01125	ENOG4107S5Z	Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity)
THEMA_RS01130	ENOG4107YBR	Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity)
THEMA_RS01140	ENOG4105C19	ABC transporter
THEMA_RS01145	ENOG4105E26	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity)
THEMA_RS01150	ENOG4105CEV	competence damage-inducible protein
THEMA_RS01155	ENOG4105CBS	Chea signal transduction histidine kinase
THEMA_RS01160	ENOG4105YVF	chew protein
THEMA_RS01165	ENOG4107YTP	response regulator receiver protein
THEMA_RS01175	ENOG4105CN7	Flagellar biosynthetic protein FliP
THEMA_RS01190	ENOG4105CCQ	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity)
THEMA_RS01195	ENOG4107XYV	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase (By similarity)
THEMA_RS01205	ENOG41082V8	Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity)
THEMA_RS01220	ENOG4105BZA	Phosphoglycerate kinase
THEMA_RS01225	ENOG4105C17	glyceraldehyde-3-phosphate dehydrogenase
THEMA_RS01230	ENOG41085TI	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity)
THEMA_RS01235	ENOG4105C6E	dna polymerase iii
THEMA_RS01265	ENOG4105DD5	Flagellar motor switch protein
THEMA_RS01270	ENOG4105D24	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity)
THEMA_RS01280	ENOG4105ER2	Ompa motb domain protein
THEMA_RS01285	ENOG4105E14	MotA TolQ exbB proton channel
THEMA_RS01290	ENOG41068WV	flagellar FlbD family protein
THEMA_RS01295	ENOG4105BZE	flagellar hook protein, FlgE
THEMA_RS01330	ENOG4105F8V	Hydrolase, tatD family
THEMA_RS01340	ENOG4105C6T	cysteine synthase
THEMA_RS01355	ENOG4105VNB	Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity)
THEMA_RS01365	ENOG4107V4F	S-adenosyl-l-methionine hydroxide adenosyltransferase
THEMA_RS01370	ENOG4105VCQ	rubredoxin
THEMA_RS01375	ENOG4108YZ8	Superoxide reductase
THEMA_RS01380	ENOG4108RAC	Rubrerythrin
THEMA_RS01385	ENOG4106A7E	Transcriptional regulator
THEMA_RS01390	ENOG4105X3E	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity)
THEMA_RS01395	ENOG4105CCX	Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity)
THEMA_RS01400	ENOG4105CIW	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity)
THEMA_RS01410	ENOG4105J7I	hydrolase
THEMA_RS01430	ENOG41082Q0	Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity)
THEMA_RS01440	ENOG4107S7H	nh(3)-dependent nad( ) synthetase
THEMA_RS01470	ENOG4105DAY	polysaccharide export protein
THEMA_RS01495	ENOG4108ZW7	flagellar rod assembly protein muramidase flgj
THEMA_RS01510	ENOG4105C1B	dTDP-glucose 4-6-dehydratase
THEMA_RS01525	ENOG4107SBE	Glycosyl transferase (Group 1
THEMA_RS01540	ENOG4107R5M	Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity)
THEMA_RS01550	ENOG4107STW	synthase
THEMA_RS01565	ENOG4107RA4	Glycosyl transferase (Group 1
THEMA_RS01610	ENOG4105EAG	UDP-N-acetylglucosamine 2-epimerase
THEMA_RS01625	ENOG4108RW0	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity)
THEMA_RS01635	ENOG4105VH8	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity)
THEMA_RS01640	ENOG4108UUM	single-stranded DNA-binding protein
THEMA_RS01645	ENOG41083EQ	Binds together with S18 to 16S ribosomal RNA (By similarity)
THEMA_RS01690	ENOG4105C7N	Xanthine uracil vitamin C permease
THEMA_RS01695	ENOG4105EAB	amino acid AbC transporter
THEMA_RS01700	ENOG4105E5Q	amino acid AbC transporter
THEMA_RS01710	ENOG4105CJN	penicillin-binding protein
THEMA_RS01725	ENOG4105DFF	Rod shape-determining protein mreb
THEMA_RS01730	ENOG4105E2M	Manganese-dependent inorganic pyrophosphatase
THEMA_RS01735	ENOG410631K	Membrane
THEMA_RS01750	ENOG4107QQG	Dehydrogenase
THEMA_RS01765	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
THEMA_RS01770	ENOG4105D3U	Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity)
THEMA_RS01780	ENOG4105II7	pyrroline-5-carboxylate reductase
THEMA_RS01785	ENOG41080E2	ribosomal-protein-alanine acetyltransferase
THEMA_RS01790	ENOG4105DE5	Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity)
THEMA_RS01795	ENOG4105NHU	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity)
THEMA_RS01800	ENOG4105E2N	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity)
THEMA_RS01805	ENOG4105CE8	Transfers the fatty acyl group on membrane lipoproteins (By similarity)
THEMA_RS01810	ENOG4105CF4	DegT DnrJ EryC1 StrS aminotransferase
THEMA_RS01815	ENOG4105C0H	protease
THEMA_RS01820	ENOG4105CCP	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)
THEMA_RS01835	ENOG4107YXA	Transcriptional regulator, BadM Rrf2 family
THEMA_RS01845	ENOG4107ZMQ	sugar fermentation stimulation protein
THEMA_RS01870	ENOG4105D7N	magnesium and cobalt transport protein CorA
THEMA_RS01885	ENOG4105C1M	carbamoyl-phosphate synthetase glutamine chain
THEMA_RS01890	ENOG4105CU6	carbamoyl-phosphate synthetase ammonia chain
THEMA_RS01895	ENOG4105C0C	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity)
THEMA_RS01900	ENOG4105MQS	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
THEMA_RS01905	ENOG4105CQI	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
THEMA_RS01915	ENOG4105CYQ	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity)
THEMA_RS01920	ENOG4105C01	Dihydroxy-acid dehydratase
THEMA_RS01935	ENOG4105C7K	acetolactate synthase
THEMA_RS01940	ENOG4105CFH	Aspartokinase
THEMA_RS01945	ENOG4108IYI	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity)
THEMA_RS01950	ENOG4105D5I	Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity)
THEMA_RS01955	ENOG4105CJ1	ABC, transporter
THEMA_RS01970	ENOG4107GFK	fumarate
THEMA_RS01980	ENOG4108JEB	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity)
THEMA_RS01985	ENOG4105PGM	cation diffusion facilitator family transporter
THEMA_RS01990	ENOG4106D4I	domain protein
THEMA_RS02005	ENOG4105DG1	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
THEMA_RS02010	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
THEMA_RS02025	ENOG4108JQ7	(ABC) transporter
THEMA_RS02030	ENOG410681U	heavy metal transport detoxification protein
THEMA_RS02035	ENOG4105CAE	Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity)
THEMA_RS02040	ENOG4105C1N	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity)
THEMA_RS02045	ENOG4105KW8	RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity)
THEMA_RS02050	ENOG4105DKX	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity)
THEMA_RS02070	ENOG4105C4N	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity)
THEMA_RS02075	ENOG4108R5P	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity)
THEMA_RS02080	ENOG4105CCJ	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity)
THEMA_RS02105	ENOG4105N5T	Radical SAM Protein
THEMA_RS02110	ENOG4105C90	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity)
THEMA_RS02115	ENOG4105C0P	Mg chelatase subunit ChlI
THEMA_RS02125	ENOG4108UN4	phage SPO1 DNA polymerase-related protein
THEMA_RS02140	ENOG4105D1H	recombination factor protein RarA
THEMA_RS02150	ENOG4105CJ9	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity)
THEMA_RS02155	ENOG41083C3	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity)
THEMA_RS02165	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
THEMA_RS02170	ENOG4105C3U	ABC transporter
THEMA_RS02175	ENOG4108JQ7	(ABC) transporter
THEMA_RS02195	ENOG4105DE5	Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity)
THEMA_RS02200	ENOG4108IAB	Phoh family
THEMA_RS02205	ENOG4105K8I	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity)
THEMA_RS02210	ENOG4108KVX	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity)
THEMA_RS02215	ENOG4105C31	Tryptophanyl-tRNA synthetase
THEMA_RS02225	ENOG4105NDF	NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity)
THEMA_RS02235	ENOG4105EQY	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity)
THEMA_RS02240	ENOG4105VG1	fes assembly suf system protein
THEMA_RS02250	ENOG4105EUS	Binding-protein-dependent transport systems, inner membrane component
THEMA_RS02260	ENOG4108IY8	ABC, transporter
THEMA_RS02290	ENOG4105C5U	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity)
THEMA_RS02300	ENOG4105DA0	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity)
THEMA_RS02305	ENOG4105QZY	s-layer domain protein
THEMA_RS02320	ENOG4106XMA	In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 (By similarity)
THEMA_RS02335	ENOG4108UHX	Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity)
THEMA_RS02355	ENOG4105DPZ	Two component transcriptional regulator (Winged helix family
THEMA_RS02365	ENOG4105CDY	transcriptional regulatory protein
THEMA_RS02375	ENOG4105BZU	Histidine kinase
THEMA_RS02380	ENOG4105C34	Pseudouridine synthase
THEMA_RS02385	ENOG4105C0B	DNA polymerase III (alpha subunit)
THEMA_RS02390	ENOG4105DEF	Extracellular solute-binding protein, family 5
THEMA_RS02395	ENOG4107QR0	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
THEMA_RS02400	ENOG4108IIJ	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
THEMA_RS02405	ENOG4105KBC	Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity)
THEMA_RS02410	ENOG41081WB	50s ribosomal protein L10
THEMA_RS02415	ENOG4105C64	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity)
THEMA_RS02425	ENOG4105E5V	Participates in transcription elongation, termination and antitermination (By similarity)
THEMA_RS02430	ENOG410683Z	Preprotein translocase SecE subunit
THEMA_RS02440	ENOG41086IP	50S ribosomal protein L33
THEMA_RS02465	ENOG41087GE	Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate (By similarity)
THEMA_RS02470	ENOG4105E1Z	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
THEMA_RS02475	ENOG4105CY8	phosphoribosylaminoimidazole carboxylase atpase subunit
THEMA_RS02480	ENOG4108UM6	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity)
THEMA_RS02490	ENOG4108IJ0	Aspartate ammonia-lyase
THEMA_RS02495	ENOG4105CMG	Carbohydrate kinase
THEMA_RS02505	ENOG4105CHR	reductase
THEMA_RS02515	ENOG4108WYP	Transcriptional regulator
THEMA_RS02520	ENOG4105C7Q	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity)
THEMA_RS02540	ENOG4107V4V	glycoside hydrolase family 4
THEMA_RS02545	ENOG4105DBA	pectate lyase
THEMA_RS02560	ENOG4105F66	Binding-protein-dependent transport systems inner membrane component
THEMA_RS02565	ENOG4105C8Q	Methyl-accepting chemotaxis
THEMA_RS02570	ENOG4105CCY	NADH flavin oxidoreductase, NADH oxidase
THEMA_RS02595	ENOG4105DCT	glycerol dehydrogenase
THEMA_RS02610	ENOG4105EG2	ABC transporter, permease
THEMA_RS02615	ENOG4105D56	permease protein
THEMA_RS02630	ENOG4107S8A	protein TIM barrel
THEMA_RS02640	ENOG4105DRI	Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity)
THEMA_RS02645	ENOG4107W9I	Creatinine amidohydrolase
THEMA_RS02650	ENOG4105CPQ	Dehydrogenase
THEMA_RS02665	ENOG4105DR5	peptidase
THEMA_RS02670	ENOG4105CMP	catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity)
THEMA_RS02685	ENOG4105DQU	oxidoreductase, subunit beta
THEMA_RS02695	ENOG4108YZA	Nitrogen regulatory protein pii
THEMA_RS02705	ENOG4107104	thymidine kinase
THEMA_RS02710	ENOG41062D9	Histidine kinase
THEMA_RS02725	ENOG4105EYU	Glutamine amido-transferase
THEMA_RS02735	ENOG4105BZ8	glutamate synthase
THEMA_RS02755	ENOG41088YS	Glycosyl transferase (Group 1
THEMA_RS02760	ENOG4105CJ1	ABC, transporter
THEMA_RS02775	ENOG4108TVJ	Nitroreductase
THEMA_RS02780	ENOG4105CJD	(Anaerobic) ribonucleoside-triphosphate reductase
THEMA_RS02790	ENOG4108TVJ	Nitroreductase
THEMA_RS02795	ENOG4105CEN	a g-specific adenine glycosylase
THEMA_RS02810	ENOG4107QMW	pyridine nucleotide-disulfide oxidoreductase
THEMA_RS02815	ENOG4105CSF	NADPH-dependent glycerol-3-phosphate dehydrogenase
THEMA_RS02820	ENOG4105EJ9	Membrane
THEMA_RS02825	ENOG4108VPX	Involved in 1,2-propanediol (1,2-PD) degradation by catalyzing the conversion of propanoyl-CoA to propanoyl-phosphate (By similarity)
THEMA_RS02830	ENOG4105VN1	Heat shock protein
THEMA_RS02835	ENOG4105CFG	Acts as a chaperone (By similarity)
THEMA_RS02850	ENOG4105EHU	Circadian clock protein KaiC
THEMA_RS02870	ENOG4105CSM	endonuclease III
THEMA_RS02875	ENOG4105DFM	M18 family aminopeptidase
THEMA_RS02880	ENOG4105CG3	alpha amylase, catalytic region
THEMA_RS02890	ENOG4105EFU	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity)
THEMA_RS02900	ENOG4105DXN	mazG family
THEMA_RS02910	ENOG4105CBD	Diacylglycerol kinase
THEMA_RS02920	ENOG4105C7B	Threonine dehydratase
THEMA_RS02935	ENOG410624X	efflux transporter, rnd family, mfp subunit
THEMA_RS02940	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
THEMA_RS02945	ENOG4108EE5	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
THEMA_RS02955	ENOG4108Z38	Catalyzes a trans-dehydration via an enolate intermediate (By similarity)
THEMA_RS02960	ENOG4105D49	3-dehydroquinate synthase
THEMA_RS02965	ENOG4105D10	5-enolpyruvylshikimate-3-phosphate phospholyase
THEMA_RS02970	ENOG4108237	shikimate dehydrogenase
THEMA_RS02975	ENOG4105CMY	5-enolpyruvylshikimate-3-phosphate synthase
THEMA_RS02985	ENOG4108JPM	phospho-2-dehydro-3-deoxyheptonate aldolase
THEMA_RS03015	ENOG4105CCT	upf0313 protein
THEMA_RS03020	ENOG4105F6J	Alpha beta hydrolase fold
THEMA_RS03025	ENOG4107VJ5	dihydroorotase
THEMA_RS03030	ENOG4105I47	Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity)
THEMA_RS03035	ENOG4107W93	Dihydroorotate dehydrogenase
THEMA_RS03040	ENOG4107YPM	Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity)
THEMA_RS03045	ENOG4107QV3	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity)
THEMA_RS03050	ENOG4105EFZ	amidohydrolase
THEMA_RS03070	ENOG4108JQ1	Dehydrogenase
THEMA_RS03075	ENOG4106KNT	transcriptional regulator
THEMA_RS03080	ENOG41061TZ	Short-chain dehydrogenase reductase Sdr
THEMA_RS03085	ENOG4105CG6	trap dicarboxylate transporter dctm subunit
THEMA_RS03095	ENOG4105DR6	Trap dicarboxylate transporter, dctp subunit
THEMA_RS03115	ENOG4105DDZ	Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity)
THEMA_RS03120	ENOG4105C59	p-type ATPase
THEMA_RS03140	ENOG4105CPC	Aldo Keto reductase
THEMA_RS03145	ENOG4105DRI	Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity)
THEMA_RS03165	ENOG4105CJQ	hydrolase, family 31
THEMA_RS03190	ENOG4108JQ7	(ABC) transporter
THEMA_RS03195	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
THEMA_RS03200	ENOG4105CJM	Binding-protein-dependent transport systems, inner membrane component
THEMA_RS03210	ENOG4105ETE	Transcriptional regulator (LacI family
THEMA_RS03215	ENOG4105CPQ	Dehydrogenase
THEMA_RS03220	ENOG4105CHR	reductase
THEMA_RS03225	ENOG4105D7K	pfkb domain protein
THEMA_RS03230	ENOG4105CW3	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity)
THEMA_RS03235	ENOG4105CGT	Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity)
THEMA_RS03240	ENOG4105C2S	Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity)
THEMA_RS03245	ENOG4105MQS	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
THEMA_RS03250	ENOG4105CQI	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
THEMA_RS03255	ENOG4105BZN	citrate synthase
THEMA_RS03260	ENOG4107UUY	ec 2.7.1.11
THEMA_RS03265	ENOG4105BZ1	(ABC) transporter
THEMA_RS03270	ENOG4105BZ1	(ABC) transporter
THEMA_RS03280	ENOG4108MDK	Dehydrogenase
THEMA_RS03285	ENOG4105CMG	Carbohydrate kinase
THEMA_RS03290	ENOG4105CR5	Class II aldolase adducin family protein
THEMA_RS03295	ENOG4105ENN	converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity)
THEMA_RS03300	ENOG4105CZZ	Alpha-N-arabinofuranosidase (EC 3.2.1.55)
THEMA_RS03310	ENOG4105DRW	binding-protein-dependent transport systems inner membrane Component
THEMA_RS03325	ENOG4105CAC	Catalyzes the conversion of L-arabinose to L-ribulose (By similarity)
THEMA_RS03335	ENOG4105C6H	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity)
THEMA_RS03340	ENOG4105D2N	Aldolase
THEMA_RS03345	ENOG4108HRN	Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity)
THEMA_RS03365	ENOG4105C3R	Methionine synthase
THEMA_RS03370	ENOG4105C1H	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity)
THEMA_RS03375	ENOG4105K70	DNA-binding protein
THEMA_RS03380	ENOG4105CII	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity)
THEMA_RS03385	ENOG4105I08	Pseudouridine synthase
THEMA_RS03390	ENOG4105CWE	NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity)
THEMA_RS03395	ENOG4105CZ8	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity)
THEMA_RS03400	ENOG4105CJ3	phosphate transporter
THEMA_RS03415	ENOG4105C73	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity)
THEMA_RS03435	ENOG4108UH4	Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity)
THEMA_RS03440	ENOG41085R6	UPF0102 protein
THEMA_RS03445	ENOG41084A9	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity)
THEMA_RS03450	ENOG4105VM8	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity)
THEMA_RS03455	ENOG4105C79	DNA protecting protein DprA
THEMA_RS03460	ENOG4107SVV	electron transport complex, RnfABCDGE type, B subunit
THEMA_RS03470	ENOG4105DZB	Electron transport complex
THEMA_RS03480	ENOG4105D6A	Electron transport complex
THEMA_RS03485	ENOG4107QTR	Required for nitrogen fixation. May be part of a membrane complex functioning as an intermediate in the electron transport to nitrogenase (By similarity)
THEMA_RS03490	ENOG4107QSQ	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity)
THEMA_RS03510	ENOG4105CNB	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity)
THEMA_RS03520	ENOG4107EEN	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity)
THEMA_RS03525	ENOG4107EES	Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity)
THEMA_RS03530	ENOG4105CPY	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity)
THEMA_RS03535	ENOG4105DMZ	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity)
THEMA_RS03540	ENOG4105CNI	cell division protein FtsW
THEMA_RS03545	ENOG4105DVQ	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity)
THEMA_RS03550	ENOG4105DFU	Cell wall formation (By similarity)
THEMA_RS03565	ENOG4107QIZ	NADH dehydrogenase
THEMA_RS03570	ENOG410902H	NADH dehydrogenase (Ubiquinone), 24 kDa subunit
THEMA_RS03580	ENOG4105K6H	D-cysteine desulfhydrase
THEMA_RS03585	ENOG4105HJX	Biotin- acetyl-CoA-carboxylase ligase
THEMA_RS03595	ENOG4108JJB	ABC transporter
THEMA_RS03600	ENOG4105C1F	The M ring may be actively involved in energy transduction (By similarity)
THEMA_RS03605	ENOG4105CS3	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity)
THEMA_RS03610	ENOG4105W2B	Flagellar assembly protein
THEMA_RS03620	ENOG4107RFA	Glycyl-tRNA synthetase beta subunit
THEMA_RS03625	ENOG4108HMW	glycyl-tRNA synthetase, alpha subunit
THEMA_RS03630	ENOG4105KME	endoribonuclease L-psp
THEMA_RS03635	ENOG4105CBI	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
THEMA_RS03640	ENOG4107QK8	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
THEMA_RS03645	ENOG4105KE9	The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity)
THEMA_RS03650	ENOG4105D43	The glycine cleavage system catalyzes the degradation of glycine (By similarity)
THEMA_RS03660	ENOG4105CTQ	phosphohexokinase
THEMA_RS03665	ENOG4105CA9	Pyruvate kinase
THEMA_RS03670	ENOG4107WCI	zn-dependent hydrolase of the beta-lactamase fold-like protein
THEMA_RS03675	ENOG4108UGV	hypoxanthine phosphoribosyltransferase
THEMA_RS03700	ENOG4107QHI	-hydrogenase
THEMA_RS03705	ENOG4105E59	Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions (By similarity)
THEMA_RS03710	ENOG4105DNJ	May play a role in the repair of endogenous alkylation damage (By similarity)
THEMA_RS03715	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
THEMA_RS03720	ENOG4107R56	PP-loop domain protein
THEMA_RS03740	ENOG4108T5I	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity)
THEMA_RS03745	ENOG4105C4B	ABC transporter, permease
THEMA_RS03770	ENOG4105MCT	stage V sporulation protein S
THEMA_RS03775	ENOG4108IPX	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity)
THEMA_RS03780	ENOG4108ESU	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Involved in the translocation of the substrate across the membrane (By similarity)
THEMA_RS03785	ENOG4105S10	periplasmic binding protein
THEMA_RS03800	ENOG4105BZU	Histidine kinase
THEMA_RS03805	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
THEMA_RS03815	ENOG4107QJF	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity)
THEMA_RS03825	ENOG4105CIW	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity)
THEMA_RS03870	ENOG4105C25	Primosomal protein n'
THEMA_RS03885	ENOG4105VNB	Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity)
THEMA_RS03890	ENOG4105EAY	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
THEMA_RS03895	ENOG4106K5Q	Modifies the topological state of DNA by introducing positive supercoils in an ATP-dependent process. It cleaves transiently a single DNA strand and remains covalently bound to the 5' DNA end through a tyrosine residue. May be involved in rewinding the DNA strands in the regions of the chromosome that have opened up to allow transcription or replication (By similarity)
THEMA_RS03900	ENOG4105C3E	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity)
THEMA_RS03905	ENOG4108WJV	had superfamily (subfamily IIIa) phosphatase
THEMA_RS03915	ENOG4105FF6	Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity)
THEMA_RS03920	ENOG4105C8T	Leucyl-tRNA synthetase
THEMA_RS03925	ENOG4105CZG	Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity)
THEMA_RS03930	ENOG4105DPM	folylpolyglutamate synthase Dihydrofolate synthase
THEMA_RS03935	ENOG4105KA4	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity)
THEMA_RS03965	ENOG4108V82	Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity)
THEMA_RS03970	ENOG4105C3B	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity)
THEMA_RS03985	ENOG4105G6Z	alkaline phosphatase
THEMA_RS03990	ENOG4105CQC	Prephenate dehydratase
THEMA_RS04010	ENOG41085U1	50S ribosomal protein L32
THEMA_RS04015	ENOG4105C6B	Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity)
THEMA_RS04020	ENOG4105C46	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity)
THEMA_RS04025	ENOG4105KEM	Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity)
THEMA_RS04030	ENOG4105CHN	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity)
THEMA_RS04035	ENOG4105CPM	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
THEMA_RS04055	ENOG4105CRQ	synthase (Component I)
THEMA_RS04060	ENOG4105DDQ	anthranilate synthase
THEMA_RS04065	ENOG4105DK0	Indole-3-glycerol phosphate synthase
THEMA_RS04070	ENOG4108ZGB	N-(5'-phosphoribosyl)anthranilate isomerase
THEMA_RS04075	ENOG4105CG0	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity)
THEMA_RS04080	ENOG4105F6H	The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity)
THEMA_RS04085	ENOG4105C55	Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs
THEMA_RS04095	ENOG4105C3M	thioredoxin reductase
THEMA_RS04100	ENOG4108W2Y	isochorismatase
THEMA_RS04105	ENOG4105I03	Flagellin
THEMA_RS04120	ENOG4107QSA	Oxaloacetate decarboxylase
THEMA_RS04130	ENOG4105DPZ	Two component transcriptional regulator (Winged helix family
THEMA_RS04135	ENOG41080V6	ABC-3 protein
THEMA_RS04140	ENOG4105FDK	ABC transporter
THEMA_RS04145	ENOG4107XSR	periplasmic solute binding protein
THEMA_RS04155	ENOG4105CK3	Lysine 2,3-aminomutase YodO family protein
THEMA_RS04160	ENOG4108TVJ	Nitroreductase
THEMA_RS04180	ENOG4105CMG	Carbohydrate kinase
THEMA_RS04185	ENOG4105C2J	ABC transporter
THEMA_RS04200	ENOG4105CNN	ABC, transporter
THEMA_RS04210	ENOG4105E2R	ROK family
THEMA_RS04220	ENOG4105CDF	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity)
THEMA_RS04240	ENOG4105UIB	(ABC) transporter
THEMA_RS04245	ENOG4108JQ9	ABC transporter
THEMA_RS04250	ENOG4105DIH	basic membrane
THEMA_RS04260	ENOG4105C77	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity)
THEMA_RS04270	ENOG4105C9R	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
THEMA_RS04275	ENOG4108Z1W	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity)
THEMA_RS04280	ENOG4105CEH	Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity)
THEMA_RS04285	ENOG4105FBB	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME) (By similarity)
THEMA_RS04325	ENOG41074MP	UPF0103 Mediator of ErbB2-driven cell motility-containing protein
THEMA_RS04330	ENOG4105CJR	Integral membrane protein (MviN
THEMA_RS04350	ENOG4105DTJ	flagellar hook-associated protein
THEMA_RS04355	ENOG4105W5T	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum (By similarity)
THEMA_RS04360	ENOG4105JKQ	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity)
THEMA_RS04365	ENOG4105EHG	Permease protein
THEMA_RS04370	ENOG4105E0A	ABC, transporter
THEMA_RS04375	ENOG4105I82	acetyl xylan esterase
THEMA_RS04385	ENOG4108JQ7	(ABC) transporter
THEMA_RS04390	ENOG4105C3U	ABC transporter
THEMA_RS04395	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
THEMA_RS04400	ENOG4105CJM	Binding-protein-dependent transport systems, inner membrane component
THEMA_RS04410	ENOG4105D9F	endo-1,4-beta-xylanase (EC 3.2.1.8)
THEMA_RS04415	ENOG4105CHZ	Catalyzes the dehydration of D-mannonate (By similarity)
THEMA_RS04420	ENOG4105DEI	Mannitol dehydrogenase
THEMA_RS04430	ENOG4108UHU	Aldolase
THEMA_RS04435	ENOG4107258	Transcriptional regulator
THEMA_RS04440	ENOG4105D2H	Uronic isomerase
THEMA_RS04455	ENOG4105D9F	endo-1,4-beta-xylanase (EC 3.2.1.8)
THEMA_RS04460	ENOG4105CJM	Binding-protein-dependent transport systems, inner membrane component
THEMA_RS04465	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
THEMA_RS04470	ENOG4105C3U	ABC transporter
THEMA_RS04475	ENOG4108JQ7	(ABC) transporter
THEMA_RS04485	ENOG4105D0H	Alpha-glucuronidase (EC 3.2.1.139)
THEMA_RS04505	ENOG4105CE1	Ferrous iron transport protein b
THEMA_RS04525	ENOG4105D7V	transposase
THEMA_RS04545	ENOG4105BZ1	(ABC) transporter
THEMA_RS04550	ENOG4105DC7	peptidase M24
THEMA_RS04555	ENOG4105K8U	2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
THEMA_RS04570	ENOG4107ZIF	6-carboxy-5,6,7,8-tetrahydropterin synthase
THEMA_RS04575	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
THEMA_RS04580	ENOG4105Q33	Has nucleotide phosphatase activity towards ATP, GTP, CTP, TTP and UTP. May hydrolyze nucleoside diphosphates with lower efficiency
THEMA_RS04605	ENOG4108J59	Extracellular solute-binding protein, family 5
THEMA_RS04625	ENOG4108JQ7	(ABC) transporter
THEMA_RS04645	ENOG4105C8Q	Methyl-accepting chemotaxis
THEMA_RS04650	ENOG4105DC6	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity)
THEMA_RS04655	ENOG4105KJJ	Uncharacterized ACR, COG1993
THEMA_RS04660	ENOG4105WMR	Protein CrcB homolog
THEMA_RS04665	ENOG4107EXU	Short-chain dehydrogenase reductase Sdr
THEMA_RS04670	ENOG4105DDK	oxidoreductase, beta subunit
THEMA_RS04675	ENOG4105D95	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity)
THEMA_RS04680	ENOG4105WGB	oxidoreductase, delta subunit
THEMA_RS04685	ENOG4105EJ5	oxidoreductase gamma subunit
THEMA_RS04700	ENOG410902H	NADH dehydrogenase (Ubiquinone), 24 kDa subunit
THEMA_RS04710	ENOG4107QIZ	NADH dehydrogenase
THEMA_RS04720	ENOG4106IPI	cyclase, family
THEMA_RS04730	ENOG4105DTQ	mandelate racemase muconate lactonizing
THEMA_RS04740	ENOG4105CGH	5'-nucleotidase
THEMA_RS04750	ENOG4108RE9	Phosphodiesterase
THEMA_RS04755	ENOG4105C20	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity)
THEMA_RS04760	ENOG4105VEQ	Cold shock protein
THEMA_RS04770	ENOG4108YXI	Secondary thiamine-phosphate synthase enzyme
THEMA_RS04780	ENOG4107U53	septum site-determining protein minD
THEMA_RS04785	ENOG4105DAN	ATP-dependent protease
THEMA_RS04790	ENOG4105EK6	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity)
THEMA_RS04795	ENOG4105C80	Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity)
THEMA_RS04805	ENOG4105Y7X	Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. Acts in DNA repair (By similarity)
THEMA_RS04820	ENOG4105CBM	Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity)
THEMA_RS04825	ENOG4105BZQ	cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase
THEMA_RS04830	ENOG41081HM	2'-5' rna ligase
THEMA_RS04835	ENOG4105C68	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity)
THEMA_RS04845	ENOG4105E4Y	Endoribonuclease that initiates mRNA decay (By similarity)
THEMA_RS04850	ENOG4105ETE	Transcriptional regulator (LacI family
THEMA_RS04860	ENOG4105E4X	binding-protein-dependent transport systems inner membrane Component
THEMA_RS04865	ENOG4105DRS	transport system, permease
THEMA_RS04890	ENOG4105E2V	Glycosyltransferase 36
THEMA_RS04900	ENOG4107T3P	ABC, transporter
THEMA_RS04915	ENOG4105D4B	ABC, transporter
THEMA_RS04920	ENOG4105CNN	ABC, transporter
THEMA_RS04930	ENOG4105E2R	ROK family
THEMA_RS04940	ENOG4108IUM	Glycogen debranching enzyme
THEMA_RS04965	ENOG4105CG3	alpha amylase, catalytic region
THEMA_RS04970	ENOG4107FKK	extracellular solute-binding protein family 1
THEMA_RS04975	ENOG4105D56	permease protein
THEMA_RS04985	ENOG4108IUK	alpha amylase, catalytic
THEMA_RS04990	ENOG4107V4V	glycoside hydrolase family 4
THEMA_RS04995	ENOG4108T5G	Adenylate
THEMA_RS05010	ENOG4105BZU	Histidine kinase
THEMA_RS05015	ENOG4105D1W	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity)
THEMA_RS05020	ENOG4108R6K	riboflavin synthase, subunit alpha
THEMA_RS05025	ENOG4105C66	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity)
THEMA_RS05040	ENOG4105EPW	hflc protein
THEMA_RS05045	ENOG4107QJR	hflk protein
THEMA_RS05050	ENOG4105GRF	N-glycosylase DNA lyase
THEMA_RS05065	ENOG4105FGV	Chromate
THEMA_RS05070	ENOG4105CA4	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity)
THEMA_RS05095	ENOG410695F	Crispr-associated protein, Csm1 family
THEMA_RS05105	ENOG4108W8W	CRISPR-associated RAMP protein, Csm3 family
THEMA_RS05115	ENOG4105G15	CRISPR-associated RAMP protein, Csm5 family
THEMA_RS05135	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
THEMA_RS05165	ENOG4105DYN	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. May be involved in the integration of spacer DNA into the CRISPR cassette (By similarity)
THEMA_RS05170	ENOG4105ZHF	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease (By similarity)
THEMA_RS05215	ENOG4105BZU	Histidine kinase
THEMA_RS05235	ENOG4105C8Y	Acetylornithine aminotransferase
THEMA_RS05240	ENOG4105CAS	nag kinase
THEMA_RS05245	ENOG4105C5V	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity)
THEMA_RS05250	ENOG4105C0N	N-acetylglutamate semialdehyde dehydrogenase
THEMA_RS05255	ENOG4105CH7	arginosuccinase
THEMA_RS05260	ENOG4105CDH	Citrulline--aspartate ligase
THEMA_RS05270	ENOG4108396	Required for maturation of 30S ribosomal subunits (By similarity)
THEMA_RS05275	ENOG4105CHV	Transcription elongation factor NusA
THEMA_RS05280	ENOG4105I3K	Ferric uptake regulator, Fur family
THEMA_RS05290	ENOG4105E3H	phosphoglycerate mutase
THEMA_RS05310	ENOG4105C2V	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity)
THEMA_RS05315	ENOG41087NB	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity)
THEMA_RS05320	ENOG4105DVS	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity)
THEMA_RS05325	ENOG4105CN0	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity)
THEMA_RS05330	ENOG4105CKU	formyltetrahydrofolate synthetase
THEMA_RS05335	ENOG4105M7K	Involved in the transcription termination process (By similarity)
THEMA_RS05345	ENOG4105DRH	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity)
THEMA_RS05355	ENOG4105CCW	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity)
THEMA_RS05390	ENOG4105CKM	Branched-chain carboxylic acid kinase
THEMA_RS05395	ENOG4107RE7	phosphate butyryltransferase
THEMA_RS05400	ENOG4105CKM	Branched-chain carboxylic acid kinase
THEMA_RS05405	ENOG4105CCW	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity)
THEMA_RS05420	ENOG4108JQ7	(ABC) transporter
THEMA_RS05425	ENOG4105C3U	ABC transporter
THEMA_RS05430	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
THEMA_RS05435	ENOG4105CJM	Binding-protein-dependent transport systems, inner membrane component
THEMA_RS05440	ENOG4107QSI	ABC, transporter
THEMA_RS05455	ENOG4108FN7	Aldo keto reductase
THEMA_RS05460	ENOG4105D4U	had-superfamily hydrolase, subfamily iia
THEMA_RS05465	ENOG4105C2N	RNA methyltransferase TrmH family group 3
THEMA_RS05470	ENOG4105KEB	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
THEMA_RS05485	ENOG4105CB1	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity)
THEMA_RS05490	ENOG4105CDU	Replicative dna helicase
THEMA_RS05500	ENOG4105QGT	Phosphate uptake regulator
THEMA_RS05505	ENOG4105F91	Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity)
THEMA_RS05515	ENOG4105DFA	alanine racemase domain protein
THEMA_RS05520	ENOG4105CKJ	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity)
THEMA_RS05530	ENOG4105CCG	Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity)
THEMA_RS05545	ENOG4106C6A	Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity)
THEMA_RS05550	ENOG4105CHR	reductase
THEMA_RS05570	ENOG4108HPG	-acetyltransferase
THEMA_RS05575	ENOG4105D86	that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity)
THEMA_RS05580	ENOG4105DJV	ribulose-phosphate 3-epimerase
THEMA_RS05585	ENOG4105E06	May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity)
THEMA_RS05595	ENOG4105C55	Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs
THEMA_RS05605	ENOG4108ZK7	protein family UPF0029, Impact, N-terminal protein
THEMA_RS05625	ENOG4105CHW	UPF0052 protein
THEMA_RS05630	ENOG4105CIE	May be required for sporulation (By similarity)
THEMA_RS05635	ENOG4108Z11	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity)
THEMA_RS05640	ENOG4108UKH	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity)
THEMA_RS05645	ENOG4105CRK	lysyL-tRNA synthetase
THEMA_RS05655	ENOG4105E0M	Sulfatase
THEMA_RS05665	ENOG4107QJQ	Mate efflux family protein
THEMA_RS05675	ENOG4108ESY	Metal dependent phosphohydrolase
THEMA_RS05700	ENOG4105D8I	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity)
THEMA_RS05720	ENOG4105KC4	UPF0296 protein
THEMA_RS05725	ENOG4108UHA	Essential for recycling GMP and indirectly, cGMP (By similarity)
THEMA_RS05735	ENOG4105CJS	Phosphopantothenoylcysteine decarboxylase
THEMA_RS05740	ENOG4107Y2H	ErfK ybiS ycfS ynhG family protein
THEMA_RS05745	ENOG4105C62	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity)
THEMA_RS05750	ENOG41084K4	Binds the 23S rRNA (By similarity)
THEMA_RS05755	ENOG4105VEQ	Cold shock protein
THEMA_RS05760	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
THEMA_RS05780	ENOG4105CPI	Metal Dependent Phosphohydrolase
THEMA_RS05810	ENOG4105D00	flagellar biosynthetic protein flhB
THEMA_RS05840	ENOG4105C93	Xylose Isomerase
THEMA_RS05845	ENOG4105C9Y	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity)
THEMA_RS05855	ENOG4107Y49	methyltransferase
THEMA_RS05860	ENOG4108JJB	ABC transporter
THEMA_RS05865	ENOG4105CV2	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity)
THEMA_RS05870	ENOG4108Z02	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity)
THEMA_RS05885	ENOG4105CPH	Catalyzes the formation of S-adenosylmethionine from methionine and ATP
THEMA_RS05900	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
THEMA_RS05905	ENOG4105BZU	Histidine kinase
THEMA_RS05920	ENOG4105CEJ	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity)
THEMA_RS05935	ENOG4108WF2	Metal Dependent Phosphohydrolase
THEMA_RS05950	ENOG4105D18	nicotinate-nucleotide pyrophosphorylase
THEMA_RS05955	ENOG4105D0I	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity)
THEMA_RS05960	ENOG4108Q27	Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate (By similarity)
THEMA_RS05965	ENOG4105CXT	aspartate transcarbamylase
THEMA_RS05970	ENOG41084X0	Dihydrofolate reductase
THEMA_RS05980	ENOG4105CDJ	oxidoreductase FAD NAD(P)-binding domain protein
THEMA_RS05985	ENOG4108IUW	ABC transporter
THEMA_RS05995	ENOG4107WZZ	SMC domain protein
THEMA_RS06000	ENOG4107RH8	nuclease SbcCD subunit D
THEMA_RS06010	ENOG4105C6P	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity)
THEMA_RS06015	ENOG4105K8N	protein family UPF0079, ATPase
THEMA_RS06030	ENOG4105CAJ	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity)
THEMA_RS06035	ENOG4105C5T	Phosphoribosyl pyrophosphate synthase
THEMA_RS06040	ENOG4105KW6	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity)
THEMA_RS06045	ENOG4108ZPD	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity)
THEMA_RS06055	ENOG4105CNT	hydrolase family 2
THEMA_RS06060	ENOG4105C4S	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity)
THEMA_RS06070	ENOG4108QXE	glycerophosphoryl diester phosphodiesterase
THEMA_RS06080	ENOG4105C2M	dna polymerase I
THEMA_RS06085	ENOG4108W5Z	CheC domain protein
THEMA_RS06100	ENOG4107RFS	it plays a direct role in the translocation of protons across the membrane (By similarity)
THEMA_RS06105	ENOG410855G	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
THEMA_RS06110	ENOG41084Y9	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
THEMA_RS06115	ENOG41085KK	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
THEMA_RS06120	ENOG4105CDG	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity)
THEMA_RS06125	ENOG4105J80	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity)
THEMA_RS06130	ENOG4105C4J	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity)
THEMA_RS06135	ENOG41082J0	Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity)
THEMA_RS06140	ENOG4105EPR	degv family
THEMA_RS06145	ENOG4105MS2	ribosomal subunit Interface protein
THEMA_RS06150	ENOG4105C03	ribonuclease
THEMA_RS06160	ENOG4105C41	Catalyzes the reversible phosphorylation of UMP to UDP (By similarity)
THEMA_RS06165	ENOG41079KZ	Major Facilitator Superfamily
THEMA_RS06170	ENOG4108Z3G	3H domain protein
THEMA_RS06175	ENOG4105CBM	Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity)
THEMA_RS06190	ENOG4105EMN	RNA polymerase sigma factor
THEMA_RS06200	ENOG4105CB1	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity)
THEMA_RS06205	ENOG4105SFS	phosphoesterase RecJ domain protein
THEMA_RS06210	ENOG4105BZU	Histidine kinase
THEMA_RS06215	ENOG4105D1F	ATP-binding protein
THEMA_RS06230	ENOG4108UUX	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity)
THEMA_RS06265	ENOG4105BZU	Histidine kinase
THEMA_RS06280	ENOG4105D1Z	hydroxypyruvate reductase
THEMA_RS06285	ENOG4105MJ2	Competence protein
THEMA_RS06305	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
THEMA_RS06310	ENOG4105CG1	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity)
THEMA_RS06315	ENOG4105CI6	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving
THEMA_RS06325	ENOG4105DX0	Hemolysin A
THEMA_RS06335	ENOG4105DI7	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity)
THEMA_RS06345	ENOG4105C3F	Signal peptidase i
THEMA_RS06350	ENOG4108YY1	This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity)
THEMA_RS06355	ENOG4108WTY	tRNA (Guanine-N(1)-)-methyltransferase
THEMA_RS06360	ENOG4105D6X	Specifically methylates guanosine-37 in various tRNAs (By similarity)
THEMA_RS06365	ENOG410836E	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity)
THEMA_RS06370	ENOG41084QK	UPF0109 protein
THEMA_RS06375	ENOG4105K5M	30s ribosomal protein S16
THEMA_RS06380	ENOG4105CB9	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
THEMA_RS06385	ENOG4105VSY	K01512 acylphosphatase EC 3.6.1.7
THEMA_RS06400	ENOG4105C6U	Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity)
THEMA_RS06410	ENOG4105FCI	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity)
THEMA_RS06420	ENOG4105W5Q	DNA repair protein (RadC
THEMA_RS06440	ENOG4105CJ2	(LipO)protein
THEMA_RS06450	ENOG4105NBF	ammecr1 domain protein
THEMA_RS06455	ENOG4105CBJ	Metal-dependent enzyme
THEMA_RS06460	ENOG4107UKG	Glycosyl transferase, family 4
THEMA_RS06470	ENOG4105DCI	Phosphohydrolase
THEMA_RS06475	ENOG4105C2R	Single-stranded-DNA-specific exonuclease (RecJ)
THEMA_RS06495	ENOG4105KTQ	flagellar basal-body rod protein
THEMA_RS06500	ENOG4105CGA	flagellar basal-body rod protein FlgG
THEMA_RS06510	ENOG4105TZT	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity)
THEMA_RS06515	ENOG4105D92	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity)
THEMA_RS06525	ENOG4105EPH	radical SAM domain protein
THEMA_RS06545	ENOG41090P5	ferredoxin-like protein
THEMA_RS06550	ENOG4105DWH	electron transfer flavoprotein-ubiquinone oxidoreductase
THEMA_RS06555	ENOG4105C10	Electron transfer flavoprotein
THEMA_RS06560	ENOG4105BZJ	Electron transfer flavoprotein
THEMA_RS06570	ENOG4105EIS	1,4-dihydroxy-2-naphthoate octaprenyltransferase
THEMA_RS06605	ENOG4105CM3	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity)
THEMA_RS06615	ENOG4105CDP	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity)
THEMA_RS06620	ENOG4105DUK	Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity)
THEMA_RS06625	ENOG4105DMJ	Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity)
THEMA_RS06635	ENOG4105CU5	Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity)
THEMA_RS06640	ENOG4105CH2	amidohydrolase
THEMA_RS06655	ENOG4105CDE	UPF0348 protein
THEMA_RS06660	ENOG4105CYJ	ribosomal RNA small subunit methyltransferase B
THEMA_RS06675	ENOG4105KGE	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity)
THEMA_RS06680	ENOG4105CTJ	Metal Dependent Phosphohydrolase
THEMA_RS06685	ENOG4105C9A	Phoh family
THEMA_RS06695	ENOG4108UKE	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity)
THEMA_RS06700	ENOG4108UHY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity)
THEMA_RS06705	ENOG4105CEJ	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity)
THEMA_RS06710	ENOG4105CGV	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity)
THEMA_RS06715	ENOG4108Z10	Involved in the binding of tRNA to the ribosomes (By similarity)
THEMA_RS06720	ENOG4105EEE	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity)
THEMA_RS06725	ENOG4106U5A	One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity)
THEMA_RS06730	ENOG4105KZR	One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity)
THEMA_RS06735	ENOG4105CFD	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
THEMA_RS06740	ENOG4105K7S	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity)
THEMA_RS06745	ENOG4105KAP	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity)
THEMA_RS06750	ENOG4105CKE	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity)
THEMA_RS06755	ENOG4108R70	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity)
THEMA_RS06760	ENOG41084ME	50s ribosomal protein l29
THEMA_RS06765	ENOG4105K87	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal
THEMA_RS06770	ENOG4108UNN	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity)
THEMA_RS06775	ENOG4105KAR	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity)
THEMA_RS06780	ENOG4105CW6	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
THEMA_RS06785	ENOG41082QR	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity)
THEMA_RS06790	ENOG4108UJY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity)
THEMA_RS06795	ENOG4108R5J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity)
THEMA_RS06800	ENOG4105K4C	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity)
THEMA_RS06805	ENOG4108RA9	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity)
THEMA_RS06810	ENOG4105VPB	50S ribosomal protein L30
THEMA_RS06815	ENOG4108UZ0	Binds to the 23S rRNA (By similarity)
THEMA_RS06820	ENOG4105CGG	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity)
THEMA_RS06825	ENOG4105CC8	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity)
THEMA_RS06835	ENOG4105K9U	however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity)
THEMA_RS06840	ENOG41086MH	50S ribosomal protein L36
THEMA_RS06845	ENOG4108Z04	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
THEMA_RS06850	ENOG4108UHH	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity)
THEMA_RS06855	ENOG4105G6W	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity)
THEMA_RS06860	ENOG4105CTF	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
THEMA_RS06865	ENOG4108ZT0	50S ribosomal protein l17
THEMA_RS06870	ENOG4105C4P	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity)
THEMA_RS06875	ENOG4105DKQ	ROK family
THEMA_RS06880	ENOG4105EPR	degv family
THEMA_RS06890	ENOG4105DHT	Metal Dependent Phosphohydrolase
THEMA_RS06895	ENOG4105WHM	Necessary for normal cell division and for the maintenance of normal septation (By similarity)
THEMA_RS06900	ENOG41068B1	Cob-I-yrinic acid a,c-diamide adenosyltransferase
THEMA_RS06905	ENOG4105D53	Catalyzes the hydrolysis of pseudouridine 5'-phosphate (PsiMP) to ribose 5-phosphate and uracil (By similarity)
THEMA_RS06910	ENOG41085QA	50S ribosomal protein l34
THEMA_RS06915	ENOG41084AH	RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity)
THEMA_RS06920	ENOG4105VAS	Could be involved in insertion of integral membrane proteins into the membrane (By similarity)
THEMA_RS06925	ENOG4105DHW	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins
THEMA_RS06940	ENOG4105KK9	This protein binds to 23S rRNA in the presence of protein L20 (By similarity)
THEMA_RS06950	ENOG4105K46	50S ribosomal protein l27
THEMA_RS06955	ENOG41081BK	membrane protein-like protein
THEMA_RS06960	ENOG4108UM5	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity)
THEMA_RS06965	ENOG4108UJD	30S ribosomal protein S9
THEMA_RS06970	ENOG4105C9G	DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity)
THEMA_RS06975	ENOG4105DG1	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
THEMA_RS06980	ENOG4108JA2	transcriptioN-repair coupling factor
THEMA_RS06995	ENOG4105K7Z	Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity)
THEMA_RS07000	ENOG4105DKZ	GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity)
THEMA_RS07005	ENOG4105CAV	thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity)
THEMA_RS07010	ENOG4105C48	Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity)
THEMA_RS07015	ENOG4107RB4	Cytidine monophosphate kinase
THEMA_RS07020	ENOG41084GC	stage II sporulation protein
THEMA_RS07025	ENOG4105C9M	aspartyl-trna synthetase
THEMA_RS07030	ENOG4105C35	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity)
THEMA_RS07040	ENOG4107RFW	hydrolase family 57
THEMA_RS07045	ENOG4105D1X	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity)
THEMA_RS07070	ENOG4107KMQ	bfd domain protein (2fe-2s)-binding domain protein
THEMA_RS07075	ENOG4108ZIA	glycerol-3-phosphate responsive antiterminator
THEMA_RS07080	ENOG4108JQ0	Key enzyme in the regulation of glycerol uptake and metabolism (By similarity)
THEMA_RS07085	ENOG4105D8C	Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity)
THEMA_RS07090	ENOG41080BE	Methyl-accepting chemotaxis sensory transducer
THEMA_RS07095	ENOG4105FF6	Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity)
THEMA_RS07100	ENOG4107QHI	-hydrogenase
THEMA_RS07105	ENOG4107QIZ	NADH dehydrogenase
THEMA_RS07110	ENOG4105GKE	subunit e
THEMA_RS07125	ENOG4105Y5S	NADH ubiquinone oxidoreductase, 24 kD
THEMA_RS07140	ENOG4108Y5D	Inherit from COG: cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase
THEMA_RS07145	ENOG4105C3K	feS assembly ATPase SufC
THEMA_RS07150	ENOG4105DIW	FeS assembly protein SUFB
THEMA_RS07160	ENOG4105ECY	inositol monophosphatase
THEMA_RS07165	ENOG4108HKT	sucrose-6-phosphate hydrolase
THEMA_RS07185	ENOG4105GSQ	TM1410 hypothetical-related protein
THEMA_RS07210	ENOG4105CPK	Glycosyl transferase (Group 1
THEMA_RS07230	ENOG4108JQ1	Dehydrogenase
THEMA_RS07235	ENOG4105C5R	Aminotransferase
THEMA_RS07245	ENOG4105CR3	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity)
THEMA_RS07250	ENOG4105KNE	Phosphatidate cytidylyltransferase
THEMA_RS07255	ENOG4105CIM	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity)
THEMA_RS07265	ENOG4107S82	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity)
THEMA_RS07270	ENOG4105CE5	Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity)
THEMA_RS07280	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
THEMA_RS07305	ENOG4106H78	methyltransferase
THEMA_RS07310	ENOG41083IT	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity)
THEMA_RS07320	ENOG4105C89	phosphohexose isomerase
THEMA_RS07325	ENOG4109003	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity)
THEMA_RS07330	ENOG4107SJN	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity)
THEMA_RS07345	ENOG4108TSD	Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity)
THEMA_RS07350	ENOG4105CGR	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity)
THEMA_RS07355	ENOG4105D38	putrescine abc transporter
THEMA_RS07360	ENOG4105F38	ABC transporter, permease
THEMA_RS07365	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
THEMA_RS07370	ENOG4107RUE	extracellular solute-binding protein family 1
THEMA_RS07380	ENOG4105CVJ	phosphoglycerate mutase
THEMA_RS07390	ENOG4107YH3	SUF system FeS assembly protein, NifU family
THEMA_RS07395	ENOG4105C9B	Cysteine desulfurase
THEMA_RS07405	ENOG4105DIW	FeS assembly protein SUFB
THEMA_RS07410	ENOG4105C3K	feS assembly ATPase SufC
THEMA_RS07425	ENOG4105VQ0	flagellar hook-basal body complex protein fliE
THEMA_RS07430	ENOG4108ZC9	flagellar basal-body rod protein flgc
THEMA_RS07435	ENOG4105Q75	Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity)
THEMA_RS07440	ENOG4105C8K	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity)
THEMA_RS07445	ENOG4105CZX	twitching motility protein
THEMA_RS07450	ENOG4105C07	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity)
THEMA_RS07455	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
THEMA_RS07460	ENOG4105BZU	Histidine kinase
THEMA_RS07485	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
THEMA_RS07500	ENOG4105C20	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity)
THEMA_RS07505	ENOG4105E5G	Alpha beta hydrolase fold
THEMA_RS07510	ENOG4107Z0G	Domain of unknown function DUF20
THEMA_RS07520	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
THEMA_RS07525	ENOG4105C1V	Peptidase, M16
THEMA_RS07535	ENOG4105K77	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity)
THEMA_RS07620	ENOG4105BZ1	(ABC) transporter
THEMA_RS07625	ENOG4108IUW	ABC transporter
THEMA_RS07640	ENOG4105C4X	radical SAM domain protein
THEMA_RS07655	ENOG4106HX1	Uncharacterised protein family (UPF0150)
THEMA_RS07665	ENOG4105BZ1	(ABC) transporter
THEMA_RS07670	ENOG4105BZ1	(ABC) transporter
THEMA_RS07690	ENOG4105PGZ	NB-ARC domain
THEMA_RS07695	ENOG4106HX1	Uncharacterised protein family (UPF0150)
THEMA_RS07705	ENOG4105ZVY	2-oxoisovalerate dehydrogenase, E1 component beta subunit
THEMA_RS07710	ENOG4105BZ1	(ABC) transporter
THEMA_RS07745	ENOG4108IUW	ABC transporter
THEMA_RS07765	ENOG4108FN7	Aldo keto reductase
THEMA_RS07775	ENOG4108JMX	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity)
THEMA_RS07785	ENOG4105DDZ	Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity)
THEMA_RS07790	ENOG4105D1F	ATP-binding protein
THEMA_RS07795	ENOG4107QMS	site-determining protein
THEMA_RS07810	ENOG4105C9R	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
THEMA_RS07815	ENOG4105W06	Cupin 2, conserved barrel domain protein
THEMA_RS07835	ENOG4108X8W	Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity)
THEMA_RS07845	ENOG41076QQ	Glycosyl transferase, family 2
THEMA_RS07850	ENOG4105F8D	glycoside hydrolase family 4
THEMA_RS07865	ENOG4105C98	muts2 protein
THEMA_RS07870	ENOG4105CIT	This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity)
THEMA_RS07890	ENOG4105CHT	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity)
THEMA_RS07895	ENOG4105C3P	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity)
THEMA_RS07900	ENOG4105X0D	Fimbrial protein
THEMA_RS07910	ENOG4107QW8	radical SAM domain protein
THEMA_RS07935	ENOG4105CVA	phosphate
THEMA_RS07950	ENOG4105BZY	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity)
THEMA_RS07955	ENOG4108UTW	Plays a role in the regulation of phosphate uptake
THEMA_RS07960	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
THEMA_RS07975	ENOG4105BZ1	(ABC) transporter
THEMA_RS07980	ENOG4105CHM	Aminotransferase
THEMA_RS07985	ENOG4105MN5	HAD-superfamily hydrolase subfamily IA variant 3
THEMA_RS07990	ENOG4105C4K	Nad synthetase
THEMA_RS08005	ENOG4107QNG	Phosphoribosylglycinamide synthetase
THEMA_RS08010	ENOG4105DC1	bifunctional purine biosynthesis protein purh
THEMA_RS08015	ENOG4108V3E	phosphoribosylglycinamide formyltransferase
THEMA_RS08025	ENOG4108JIU	phosphoribosylformylglycinamidine synthase ii
THEMA_RS08030	ENOG4105D21	Phosphoribosylformylglycinamidine synthase I
THEMA_RS08035	ENOG4108A1T	Phosphoribosylformylglycinamidine synthase, purS
THEMA_RS08040	ENOG4105C8V	SAICAR synthetase
THEMA_RS08055	ENOG4105C3G	gtp-binding protein
THEMA_RS08065	ENOG4105C4R	Atp-dependent dna helicase
THEMA_RS08090	ENOG4108IJ9	(ABC) transporter
THEMA_RS08095	ENOG4105C8I	hydrolase, family 38
THEMA_RS08100	ENOG4105IRK	Glycosyl transferase (Group 1
THEMA_RS08105	ENOG4106J7S	Glycosyl transferase, family 2
THEMA_RS08120	ENOG4107QRA	Extracellular solute-binding protein, family 5
THEMA_RS08125	ENOG4105CKB	glycosidase
THEMA_RS08130	ENOG4105E2R	ROK family
THEMA_RS08135	ENOG4108J59	Extracellular solute-binding protein, family 5
THEMA_RS08140	ENOG4105CJM	Binding-protein-dependent transport systems, inner membrane component
THEMA_RS08145	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
THEMA_RS08155	ENOG4108JQ7	(ABC) transporter
THEMA_RS08160	ENOG4105ETE	Transcriptional regulator (LacI family
THEMA_RS08170	ENOG4105CQV	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
THEMA_RS08175	ENOG4105CQV	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
THEMA_RS08180	ENOG4105ES3	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
THEMA_RS08195	ENOG4108JPZ	Monovalent cation H antiporter subunit D
THEMA_RS08205	ENOG4105D65	subunit l
THEMA_RS08220	ENOG410684G	monovalent cation H antiporter subunit F
THEMA_RS08225	ENOG4105SC1	monovalent cation H antiporter subunit E
THEMA_RS08230	ENOG4107FKK	extracellular solute-binding protein family 1
THEMA_RS08235	ENOG4105D56	permease protein
THEMA_RS08240	ENOG4105EG2	ABC transporter, permease
THEMA_RS08250	ENOG4105ETE	Transcriptional regulator (LacI family
THEMA_RS08265	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
THEMA_RS08270	ENOG4108JQ7	(ABC) transporter
THEMA_RS08285	ENOG4105CNT	hydrolase family 2
THEMA_RS08290	ENOG4107R49	K07407 alpha-galactosidase EC 3.2.1.22
THEMA_RS08295	ENOG4105F0Z	galactose-1-phosphate uridylyltransferase
THEMA_RS08300	ENOG4105CRD	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity)
THEMA_RS08320	ENOG4107WSY	Domain of unknown function DUF20
THEMA_RS08330	ENOG4108Z5K	methylglyoxal synthase
THEMA_RS08335	ENOG4105BZU	Histidine kinase
THEMA_RS08340	ENOG4107SET	aldo keto reductase
THEMA_RS08345	ENOG4105CDB	Required for chromosome condensation and partitioning (By similarity)
THEMA_RS08350	ENOG4108YZ4	nudix hydrolase
THEMA_RS08360	ENOG4105MQ3	flagellar protein FliS
THEMA_RS08365	ENOG4108RTV	Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity)
THEMA_RS08370	ENOG4107VXZ	Hydrolase
THEMA_RS08395	ENOG4105EJ7	Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity)
THEMA_RS08405	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
THEMA_RS08410	ENOG4105CHR	reductase
THEMA_RS08415	ENOG4107R76	Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity)
THEMA_RS08425	ENOG4105CSA	Coproporphyrinogen iii oxidase
THEMA_RS08430	ENOG4105DQU	oxidoreductase, subunit beta
THEMA_RS08440	ENOG4108KHP	Diguanylate cyclase
THEMA_RS08445	ENOG4105E8R	UPF0173 metal-dependent hydrolase
THEMA_RS08450	ENOG4105CJW	magnesium transporter
THEMA_RS08480	ENOG41067S9	phage shock protein C, PspC
THEMA_RS08485	ENOG4105D8W	glucose-6-phosphate 1-dehydrogenase
THEMA_RS08490	ENOG4108Q79	6-phosphogluconolactonase (EC 3.1.1.31)
THEMA_RS08505	ENOG4108JQ7	(ABC) transporter
THEMA_RS08510	ENOG4105DEF	Extracellular solute-binding protein, family 5
THEMA_RS08515	ENOG4105CJM	Binding-protein-dependent transport systems, inner membrane component
THEMA_RS08525	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
THEMA_RS08530	ENOG4105C8Q	Methyl-accepting chemotaxis
THEMA_RS08540	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
THEMA_RS08550	ENOG4105C8Q	Methyl-accepting chemotaxis
THEMA_RS08560	ENOG4107QIV	Cytochrome c biogenesis protein
THEMA_RS08565	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
THEMA_RS08570	ENOG4108IV0	ABC, transporter
THEMA_RS08575	ENOG4105C0Z	ABC transporter
THEMA_RS08580	ENOG4105CF8	branched-chain amino acid ABC transporter, permease
THEMA_RS08585	ENOG4105C32	Amino acid ABC transporter (Permease)
THEMA_RS08605	ENOG4105C7R	Atpase associated with various cellular activities aaa_3
THEMA_RS08610	ENOG4105C1I	TRANSCRIPTIONAl REGULATOR GntR family
THEMA_RS08615	ENOG4107RE7	phosphate butyryltransferase
THEMA_RS08620	ENOG41083B7	nucleosidase (EC 3.2.2.9)
THEMA_RS08650	ENOG4107V1F	Flagellar hook-associated 2 domain-containing protein
THEMA_RS08740	ENOG4108JPZ	Monovalent cation H antiporter subunit D
THEMA_RS08755	ENOG4108ZBM	Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity)
THEMA_RS08760	ENOG4108RE9	Phosphodiesterase
THEMA_RS08770	ENOG4108ZMD	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity)
THEMA_RS08780	ENOG4105DBV	ornithine carbamoyltransferase
THEMA_RS08785	ENOG4105C91	Plays an important role in the de novo pathway of purine nucleotide biosynthesis
THEMA_RS08790	ENOG4105C83	adenylosuccinate lyase
THEMA_RS08795	ENOG4105BZT	Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity)
THEMA_RS08800	ENOG4105C75	arginyL-tRNA synthetase
THEMA_RS08815	ENOG4105CUT	histidyl-tRNA synthetase
THEMA_RS08820	ENOG4105D37	Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity)
THEMA_RS08830	ENOG4107VEG	TrkA-N domain protein
THEMA_RS08845	ENOG4105CKH	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity)
THEMA_RS08850	ENOG4105C24	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
THEMA_RS08855	ENOG4106FU4	Archease protein family (MTH1598/TM1083)
THEMA_RS08860	ENOG4105DS7	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity)
THEMA_RS08865	ENOG410682B	stage II sporulation protein
THEMA_RS08870	ENOG4108YZG	isomerase
THEMA_RS08875	ENOG4105F59	Methylates ribosomal protein L11 (By similarity)
THEMA_RS08885	ENOG4108IAA	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity)
THEMA_RS08905	ENOG4105DET	Rhamnulokinase
THEMA_RS08915	ENOG4105C9F	isomerase
THEMA_RS08925	ENOG4105E98	transcriptional regulator DeoR family
THEMA_RS08930	ENOG4107V4V	glycoside hydrolase family 4
THEMA_RS08940	ENOG4105CJM	Binding-protein-dependent transport systems, inner membrane component
THEMA_RS08945	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
THEMA_RS08950	ENOG4105C3U	ABC transporter
THEMA_RS08955	ENOG4108JQ7	(ABC) transporter
THEMA_RS08960	ENOG4105CNT	hydrolase family 2
THEMA_RS08975	ENOG4105MCT	stage V sporulation protein S
THEMA_RS08985	ENOG4107SVH	Potassium channel protein
THEMA_RS08990	ENOG4108531	cuta1 divalent ion tolerance protein
THEMA_RS09000	ENOG4108IUZ	ABC transporter
THEMA_RS09010	ENOG4105KQC	Competence protein
THEMA_RS09035	ENOG4107YDG	Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity)
THEMA_RS09050	ENOG4105D7V	transposase
THEMA_RS09065	ENOG4105CEK	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity)
THEMA_RS09070	ENOG4105CIH	Imidazole acetol-phosphate transaminase
THEMA_RS09080	ENOG4108UJE	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity)
THEMA_RS09090	ENOG4105C0S	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity)
THEMA_RS09095	ENOG4105K8F	Phosphoribosyl-amp cyclohydrolase
THEMA_RS09100	ENOG4105EAG	UDP-N-acetylglucosamine 2-epimerase
THEMA_RS09105	ENOG4105CJT	Mannose-1-phosphate guanylyltransferase
THEMA_RS09130	ENOG4105CIG	ABC transporter
THEMA_RS09170	ENOG4107RCC	Major Facilitator Superfamily
THEMA_RS09195	ENOG4105D82	Glutamate dehydrogenase
THEMA_RS09225	ENOG4105CV8	reductase
THEMA_RS09235	ENOG4107SET	aldo keto reductase
THEMA_RS09240	ENOG4105CF7	AraC family transcriptional regulator
THEMA_RS09270	ENOG41060KZ	Hepn domain protein
THEMA_RS09320	ENOG4105C0D	helicase
THEMA_RS09340	ENOG4108QJJ	Protein of unknown function (DUF1175)
THEMA_RS09350	ENOG4107S85	alpha-2-macroglobulin domain protein
THEMA_RS09355	ENOG41084XP	SirA-like domain-containing protein
THEMA_RS09360	ENOG4105CUC	YeeE YedE family protein
THEMA_RS09380	ENOG41084XP	SirA-like domain-containing protein
THEMA_RS09405	ENOG4105BZU	Histidine kinase
THEMA_RS09430	ENOG4108I7H	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
THEMA_RS09440	ENOG4105DTC	1-(5-phosphoribosyl)-5-amino-4-imidazole-carboxylate (air) carboxylase
THEMA_RS09445	ENOG4108086	Protein of unknown function DUF111
THEMA_RS09460	ENOG4108V0P	LemA family
THEMA_RS09465	ENOG4108RVA	ribokinase
THEMA_RS09470	ENOG4105MRB	Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity)
THEMA_RS09475	ENOG4105E9V	Periplasmic binding protein LacI transcriptional regulator
THEMA_RS09485	ENOG4105C2J	ABC transporter
THEMA_RS09490	ENOG4105CNN	ABC, transporter
THEMA_RS09495	ENOG4108HHA	Transketolase
THEMA_RS09500	ENOG4108IUS	Transketolase
THEMA_RS09505	ENOG4108JQ0	Key enzyme in the regulation of glycerol uptake and metabolism (By similarity)
THEMA_RS09550	ENOG4105C5F	glutamine synthetase
THEMA_RS09570	ENOG4105EI2	Pseudouridine synthase
THEMA_RS09575	ENOG4108Z2X	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity)
THEMA_RS09590	ENOG4105D6T	Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity)
THEMA_RS09595	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
THEMA_RS09600	ENOG4107R3E	Citrate transporter
THEMA_RS09625	ENOG4105EZM	VWA-like domain (DUF2201)
THEMA_RS09630	ENOG41063SX	
THEMA_RS09635	ENOG41084T3	4fe-4S ferredoxin iron-sulfur binding domain-containing protein
THEMA_RS09665	ENOG4105DRS	transport system, permease
THEMA_RS09680	ENOG4105M02	This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity)
THEMA_RS09730	ENOG41084RN	Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity)
THEMA_RS09805	ENOG4107SDU	Methyl-accepting chemotaxis