locus-tag	class	description
THMC_RS00010	COG4948	Mandelate Racemase Muconate Lactonizing
THMC_RS00020	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
THMC_RS00055	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
THMC_RS00060	COG1144	Oxidoreductase
THMC_RS00065	COG0674	pyruvate-flavodoxin oxidoreductase activity
THMC_RS00070	COG1013	pyruvate-flavodoxin oxidoreductase activity
THMC_RS00075	COG1028	Short-chain dehydrogenase reductase Sdr
THMC_RS00080	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
THMC_RS00085	COG1993	acr, cog1993
THMC_RS00090	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
THMC_RS00095	COG0840	transmembrane signaling receptor activity
THMC_RS00105	COG1472	Belongs to the glycosyl hydrolase 3 family
THMC_RS00115	COG4608	Belongs to the ABC transporter superfamily
THMC_RS00120	COG0444	Belongs to the ABC transporter superfamily
THMC_RS00130	COG0601	transmembrane transport
THMC_RS00135	COG4166	transmembrane transport
THMC_RS00160	COG1618	nucleotide phosphatase activity, acting on free nucleotides
THMC_RS00165	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
THMC_RS00165	COG2199	diguanylate cyclase activity
THMC_RS00170	COG0720	synthase
THMC_RS00180	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
THMC_RS00185	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
THMC_RS00185	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
THMC_RS00190	COG0006	proline dipeptidase activity
THMC_RS00195	COG1132	(ABC) transporter
THMC_RS00215	COG0675	Transposase, IS605 OrfB family
THMC_RS00225	COG2006	4fe-4S ferredoxin, iron-sulfur binding domain protein
THMC_RS00235	COG1918	ferrous iron import across plasma membrane
THMC_RS00235	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
THMC_RS00255	COG3661	Belongs to the glycosyl hydrolase 67 family
THMC_RS00260	COG0747	negative chemotaxis
THMC_RS00265	COG4608	Belongs to the ABC transporter superfamily
THMC_RS00270	COG0444	Belongs to the ABC transporter superfamily
THMC_RS00275	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
THMC_RS00280	COG0601	transmembrane transport
THMC_RS00285	COG3693	PFAM glycoside hydrolase, family 10
THMC_RS00300	COG1904	glucuronate isomerase
THMC_RS00305	COG1414	Transcriptional regulator
THMC_RS00310	COG0800	Aldolase
THMC_RS00320	COG0246	Mannitol dehydrogenase
THMC_RS00325	COG1312	Catalyzes the dehydration of D-mannonate
THMC_RS00340	COG0601	transmembrane transport
THMC_RS00345	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
THMC_RS00355	COG4608	Belongs to the ABC transporter superfamily
THMC_RS00360	COG1472	Belongs to the glycosyl hydrolase 3 family
THMC_RS00365	COG3458	cephalosporin-C deacetylase activity
THMC_RS00370	COG1120	ATPase activity
THMC_RS00375	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
THMC_RS00380	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
THMC_RS00385	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
THMC_RS00390	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
THMC_RS00410	COG0728	peptidoglycan biosynthetic process
THMC_RS00415	COG1355	regulation of microtubule-based process
THMC_RS00450	COG1459	type II secretion system
THMC_RS00455	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
THMC_RS00460	COG3116	cell division
THMC_RS00460	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
THMC_RS00465	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
THMC_RS00470	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
THMC_RS00480	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
THMC_RS00490	COG1744	ABC transporter substrate-binding protein PnrA-like
THMC_RS00495	COG3845	ABC transporter
THMC_RS00500	COG4603	Belongs to the binding-protein-dependent transport system permease family
THMC_RS00505	COG1079	Belongs to the binding-protein-dependent transport system permease family
THMC_RS00520	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
THMC_RS00530	COG1940	carbohydrate kinase activity
THMC_RS00540	COG1172	Belongs to the binding-protein-dependent transport system permease family
THMC_RS00555	COG1129	ABC transporter
THMC_RS00560	COG1070	Carbohydrate kinase
THMC_RS00580	COG0778	Nitroreductase
THMC_RS00585	COG1509	lysine 2,3-aminomutase activity
THMC_RS00595	COG0803	Belongs to the bacterial solute-binding protein 9 family
THMC_RS00600	COG1121	(ABC) transporter
THMC_RS00605	COG1108	ABC-type Mn2 Zn2 transport systems permease components
THMC_RS00610	COG0745	RESPONSE REGULATOR receiver
THMC_RS00635	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
THMC_RS00640	COG1335	isochorismatase
THMC_RS00645	COG0492	ferredoxin-NADP+ reductase activity
THMC_RS00655	COG0820	rRNA (adenine-C2-)-methyltransferase activity
THMC_RS00660	COG0159	tryptophan synthase activity
THMC_RS00665	COG0133	tryptophan synthase activity
THMC_RS00670	COG0135	phosphoribosylanthranilate isomerase activity
THMC_RS00675	COG0134	indole-3-glycerol-phosphate synthase activity
THMC_RS00680	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
THMC_RS00680	COG0512	Glutamine amidotransferase of anthranilate synthase
THMC_RS00685	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
THMC_RS00705	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
THMC_RS00710	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
THMC_RS00715	COG0799	negative regulation of ribosome biogenesis
THMC_RS00720	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
THMC_RS00725	COG0416	fatty acid biosynthetic process
THMC_RS00730	COG0333	Belongs to the bacterial ribosomal protein bL32 family
THMC_RS00755	COG1785	Belongs to the alkaline phosphatase family
THMC_RS00770	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
THMC_RS00775	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
THMC_RS00805	COG0632	four-way junction helicase activity
THMC_RS00810	COG0285	dihydrofolate synthase activity
THMC_RS00815	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
THMC_RS00820	COG0495	leucyl-tRNA aminoacylation
THMC_RS00825	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
THMC_RS00835	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
THMC_RS00840	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
THMC_RS00845	COG1110	DNA topoisomerase II activity
THMC_RS00850	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
THMC_RS00855	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
THMC_RS00865	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
THMC_RS00870	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
THMC_RS00915	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
THMC_RS00925	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
THMC_RS00940	COG0784	Response regulator, receiver
THMC_RS00940	COG2205	protein histidine kinase activity
THMC_RS00955	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
THMC_RS00960	COG4139	cobalamin transport
THMC_RS00965	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
THMC_RS00970	COG2359	stage V sporulation protein S
THMC_RS00995	COG0390	transport system, permease component
THMC_RS01000	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
THMC_RS01020	COG0037	tRNA processing
THMC_RS01025	COG0542	response to heat
THMC_RS01030	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
THMC_RS01035	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
THMC_RS01060	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
THMC_RS01065	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
THMC_RS01070	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
THMC_RS01075	COG0469	pyruvate kinase activity
THMC_RS01080	COG0205	6-phosphofructokinase activity
THMC_RS01090	COG0404	The glycine cleavage system catalyzes the degradation of glycine
THMC_RS01095	COG0509	glycine decarboxylation via glycine cleavage system
THMC_RS01100	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
THMC_RS01105	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
THMC_RS01115	COG0752	glycyl-tRNA synthetase alpha subunit
THMC_RS01120	COG0751	glycine-tRNA ligase activity
THMC_RS01125	COG1157	protein secretion by the type III secretion system
THMC_RS01135	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
THMC_RS01140	COG1766	The M ring may be actively involved in energy transduction
THMC_RS01145	COG1122	ATPase activity
THMC_RS01155	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
THMC_RS01155	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
THMC_RS01160	COG2515	1-aminocyclopropane-1-carboxylate deaminase
THMC_RS01190	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
THMC_RS01195	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
THMC_RS01200	COG0772	Belongs to the SEDS family
THMC_RS01205	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
THMC_RS01210	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
THMC_RS01215	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
THMC_RS01220	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
THMC_RS01230	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
THMC_RS01250	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
THMC_RS01255	COG4656	Part of a membrane complex involved in electron transport
THMC_RS01260	COG4658	electron transport chain
THMC_RS01270	COG4660	Part of a membrane complex involved in electron transport
THMC_RS01280	COG1148	4fe-4S ferredoxin, iron-sulfur binding domain protein
THMC_RS01280	COG2878	Part of a membrane complex involved in electron transport
THMC_RS01285	COG0758	DNA mediated transformation
THMC_RS01290	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
THMC_RS01295	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
THMC_RS01300	COG0792	nuclease activity
THMC_RS01305	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
THMC_RS01320	COG3481	metal-dependent phosphohydrolase, HD sub domain
THMC_RS01325	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
THMC_RS01340	COG0306	phosphate transporter
THMC_RS01345	COG0592	DNA-directed DNA polymerase activity
THMC_RS01350	COG0445	tRNA wobble uridine modification
THMC_RS01355	COG1187	pseudouridine synthase activity
THMC_RS01360	COG0322	excinuclease ABC activity
THMC_RS01365	COG0776	regulation of translation
THMC_RS01370	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
THMC_RS01375	COG0646	methionine synthase
THMC_RS01375	COG1410	methionine synthase
THMC_RS01385	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
THMC_RS01385	COG0646	methionine synthase
THMC_RS01395	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
THMC_RS01395	COG0574	Belongs to the PEP-utilizing enzyme family
THMC_RS01400	COG0191	fructose-bisphosphate aldolase activity
THMC_RS01405	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
THMC_RS01415	COG2160	L-arabinose isomerase activity
THMC_RS01425	COG1175	transmembrane transport
THMC_RS01430	COG0395	ABC-type sugar transport system, permease component
THMC_RS01440	COG3534	alpha-L-arabinofuranosidase
THMC_RS01450	COG0235	Class ii aldolase
THMC_RS01460	COG0371	Dehydrogenase
THMC_RS01470	COG1132	(ABC) transporter
THMC_RS01475	COG1132	(ABC) transporter
THMC_RS01480	COG0205	6-phosphofructokinase activity
THMC_RS01485	COG0372	Belongs to the citrate synthase family
THMC_RS01490	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
THMC_RS01495	COG0066	3-isopropylmalate dehydratase activity
THMC_RS01500	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
THMC_RS01505	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
THMC_RS01510	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
THMC_RS01515	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
THMC_RS01520	COG1028	Short-chain dehydrogenase reductase Sdr
THMC_RS01525	COG1063	alcohol dehydrogenase
THMC_RS01540	COG0601	transmembrane transport
THMC_RS01545	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
THMC_RS01550	COG4608	Belongs to the ABC transporter superfamily
THMC_RS01575	COG1501	Belongs to the glycosyl hydrolase 31 family
THMC_RS01580	COG0747	negative chemotaxis
THMC_RS01595	COG0673	inositol 2-dehydrogenase activity
THMC_RS01600	COG0667	Aldo Keto reductase
THMC_RS01620	COG2217	Heavy metal translocating P-type atpase
THMC_RS01625	COG2226	methyltransferase
THMC_RS01645	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
THMC_RS01655	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
THMC_RS01660	COG1028	Short-chain dehydrogenase reductase Sdr
THMC_RS01665	COG1737	Transcriptional regulator
THMC_RS01670	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
THMC_RS01690	COG1574	metal-dependent hydrolase with the TIM-barrel fold
THMC_RS01695	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
THMC_RS01700	COG0284	orotidine-5'-phosphate decarboxylase activity
THMC_RS01705	COG0167	dihydroorotate dehydrogenase activity
THMC_RS01710	COG0543	2 iron, 2 sulfur cluster binding
THMC_RS01715	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
THMC_RS01720	COG1073	alpha beta
THMC_RS01725	COG1032	radical SAM domain protein
THMC_RS01755	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
THMC_RS01765	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
THMC_RS01770	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
THMC_RS01775	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
THMC_RS01780	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
THMC_RS01780	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
THMC_RS01785	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
THMC_RS01795	COG1136	(ABC) transporter
THMC_RS01795	COG0577	efflux transmembrane transporter activity
THMC_RS01800	COG1136	(ABC) transporter
THMC_RS01805	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
THMC_RS01820	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
THMC_RS01830	COG1597	lipid kinase activity
THMC_RS01835	COG0438	transferase activity, transferring glycosyl groups
THMC_RS01840	COG3956	TIGRFAM MazG family protein
THMC_RS01850	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
THMC_RS01860	COG0366	Alpha amylase catalytic
THMC_RS01865	COG1362	aminopeptidase activity
THMC_RS01870	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
THMC_RS01890	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
THMC_RS01895	COG1438	arginine binding
THMC_RS01905	COG0443	Heat shock 70 kDa protein
THMC_RS01910	COG0071	Belongs to the small heat shock protein (HSP20) family
THMC_RS01915	COG4869	propanediol catabolic process
THMC_RS01920	COG0730	response to heat
THMC_RS01925	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
THMC_RS01930	COG0446	pyridine nucleotide-disulphide oxidoreductase
THMC_RS01945	COG1194	a g-specific adenine glycosylase
THMC_RS01950	COG0778	Nitroreductase
THMC_RS01965	COG0778	Nitroreductase
THMC_RS01980	COG1131	(ABC) transporter
THMC_RS01985	COG0438	transferase activity, transferring glycosyl groups
THMC_RS02005	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
THMC_RS02005	COG0493	'glutamate synthase
THMC_RS02015	COG0067	glutamate synthase
THMC_RS02030	COG3850	Histidine kinase
THMC_RS02030	COG5002	protein histidine kinase activity
THMC_RS02035	COG1435	thymidine kinase activity
THMC_RS02040	COG0004	ammonium transporteR
THMC_RS02045	COG0347	Belongs to the P(II) protein family
THMC_RS02055	COG1013	pyruvate-flavodoxin oxidoreductase activity
THMC_RS02070	COG2201	protein-glutamate methylesterase activity
THMC_RS02075	COG0739	heme binding
THMC_RS02090	COG1063	alcohol dehydrogenase
THMC_RS02095	COG1402	creatininase
THMC_RS02100	COG0673	inositol 2-dehydrogenase activity
THMC_RS02110	COG1082	Xylose isomerase domain protein TIM barrel
THMC_RS02115	COG0672	)-iron permease
THMC_RS02125	COG1175	transmembrane transport
THMC_RS02130	COG3833	ABC-type maltose transport systems, permease component
THMC_RS02135	COG3842	ATPase activity
THMC_RS02145	COG0371	Dehydrogenase
THMC_RS02170	COG1902	pentaerythritol trinitrate reductase activity
THMC_RS02175	COG0840	transmembrane signaling receptor activity
THMC_RS02180	COG0395	ABC-type sugar transport system, permease component
THMC_RS02185	COG1175	transmembrane transport
THMC_RS02195	COG3866	Pectate lyase
THMC_RS02200	COG1486	melibiose metabolic process
THMC_RS02205	COG3458	cephalosporin-C deacetylase activity
THMC_RS02220	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
THMC_RS02225	COG1802	Transcriptional regulator
THMC_RS02235	COG1028	Short-chain dehydrogenase reductase Sdr
THMC_RS02245	COG1070	Carbohydrate kinase
THMC_RS02250	COG1027	Aspartate ammonia-lyase
THMC_RS02255	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
THMC_RS02260	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
THMC_RS02265	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
THMC_RS02270	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
THMC_RS02275	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
THMC_RS02300	COG0267	Belongs to the bacterial ribosomal protein bL33 family
THMC_RS02310	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
THMC_RS02315	COG0250	Participates in transcription elongation, termination and antitermination
THMC_RS02325	COG0081	regulation of translation
THMC_RS02330	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
THMC_RS02335	COG0222	ribosome binding
THMC_RS02340	COG0085	RNA polymerase activity
THMC_RS02345	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
THMC_RS02355	COG0587	DNA-directed DNA polymerase activity
THMC_RS02360	COG0564	pseudouridine synthase activity
THMC_RS02365	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
THMC_RS02375	COG0217	transcriptional regulatory protein
THMC_RS02385	COG0745	RESPONSE REGULATOR receiver
THMC_RS02405	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
THMC_RS02420	COG1335	isochorismatase
THMC_RS02435	COG1196	nuclear chromosome segregation
THMC_RS02440	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
THMC_RS02445	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
THMC_RS02450	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
THMC_RS02480	COG1116	anion transmembrane transporter activity
THMC_RS02490	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
THMC_RS02500	COG2151	metal-sulfur cluster biosynthetic enzyme
THMC_RS02505	COG2890	protein-(glutamine-N5) methyltransferase activity
THMC_RS02515	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
THMC_RS02525	COG0180	Tryptophanyl-tRNA synthetase
THMC_RS02530	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
THMC_RS02535	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
THMC_RS02540	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
THMC_RS02555	COG0444	Belongs to the ABC transporter superfamily
THMC_RS02565	COG4608	Belongs to the ABC transporter superfamily
THMC_RS02570	COG0444	Belongs to the ABC transporter superfamily
THMC_RS02575	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
THMC_RS02580	COG0601	transmembrane transport
THMC_RS02585	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
THMC_RS02590	COG0459	protein refolding
THMC_RS02600	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
THMC_RS02600	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
THMC_RS02615	COG1573	uracil-dna glycosylase
THMC_RS02625	COG0606	chelatase, subunit chli
THMC_RS02630	COG0442	prolyl-tRNA aminoacylation
THMC_RS02635	COG1242	4 iron, 4 sulfur cluster binding
THMC_RS02660	COG0482	sulfurtransferase activity
THMC_RS02665	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
THMC_RS02670	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
THMC_RS02690	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
THMC_RS02695	COG1923	regulation of RNA biosynthetic process
THMC_RS02700	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
THMC_RS02705	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
THMC_RS02710	COG2608	mercury ion transmembrane transporter activity
THMC_RS02715	COG4608	Belongs to the ABC transporter superfamily
THMC_RS02720	COG0747	negative chemotaxis
THMC_RS02725	COG0601	transmembrane transport
THMC_RS02730	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
THMC_RS02735	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
THMC_RS02750	COG4717	serine-type aminopeptidase activity
THMC_RS02760	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
THMC_RS02770	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
THMC_RS02770	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
THMC_RS02785	COG1131	(ABC) transporter
THMC_RS02790	COG0083	homoserine kinase activity
THMC_RS02795	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
THMC_RS02800	COG0527	aspartate kinase activity
THMC_RS02805	COG0028	Belongs to the TPP enzyme family
THMC_RS02810	COG0440	acetolactate synthase activity
THMC_RS02820	COG0129	dihydroxy-acid dehydratase activity
THMC_RS02825	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
THMC_RS02835	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
THMC_RS02840	COG0066	3-isopropylmalate dehydratase activity
THMC_RS02845	COG0473	3-isopropylmalate dehydrogenase activity
THMC_RS02850	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
THMC_RS02855	COG0505	Belongs to the CarA family
THMC_RS02870	COG0598	Magnesium transport protein CorA
THMC_RS02895	COG1489	DNA binding
THMC_RS02905	COG1959	2 iron, 2 sulfur cluster binding
THMC_RS02920	COG0552	protein localization to endoplasmic reticulum
THMC_RS02925	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
THMC_RS02930	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
THMC_RS02935	COG0815	Transfers the fatty acyl group on membrane lipoproteins
THMC_RS02940	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
THMC_RS02945	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
THMC_RS02950	COG2176	DNA-directed DNA polymerase activity
THMC_RS02955	COG0456	acetyltransferase
THMC_RS02960	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
THMC_RS02970	COG0037	tRNA processing
THMC_RS02975	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
THMC_RS03000	COG0673	inositol 2-dehydrogenase activity
THMC_RS03005	COG0697	spore germination
THMC_RS03010	COG0517	IMP dehydrogenase activity
THMC_RS03010	COG1227	inorganic diphosphatase activity
THMC_RS03015	COG1077	Cell shape determining protein MreB Mrl
THMC_RS03030	COG0768	penicillin binding
THMC_RS03040	COG0765	amino acid transport
THMC_RS03045	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
THMC_RS03050	COG2252	PERMEase
THMC_RS03060	COG1175	transmembrane transport
THMC_RS03070	COG0395	ABC-type sugar transport system, permease component
THMC_RS03095	COG0360	Binds together with S18 to 16S ribosomal RNA
THMC_RS03100	COG0629	single-stranded DNA binding
THMC_RS03105	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
THMC_RS03115	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
THMC_RS03170	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
THMC_RS03170	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
THMC_RS03175	COG0297	glycogen (starch) synthase activity
THMC_RS03175	COG0438	transferase activity, transferring glycosyl groups
THMC_RS03185	COG1216	Glycosyl transferase, family 2
THMC_RS03185	COG1442	glycosyl transferase family 8
THMC_RS03190	COG0438	transferase activity, transferring glycosyl groups
THMC_RS03200	COG0438	transferase activity, transferring glycosyl groups
THMC_RS03215	COG0438	transferase activity, transferring glycosyl groups
THMC_RS03230	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
THMC_RS03240	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
THMC_RS03245	COG3951	Flagellar rod assembly protein muramidase FlgJ
THMC_RS03245	COG1705	Flagellar rod assembly protein muramidase FlgJ
THMC_RS03270	COG1596	polysaccharide export
THMC_RS03280	COG1011	Hydrolase
THMC_RS03300	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
THMC_RS03310	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
THMC_RS03330	COG0561	phosphatase activity
THMC_RS03340	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
THMC_RS03345	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
THMC_RS03350	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
THMC_RS03355	COG1476	TRANSCRIPTIONal
THMC_RS03360	COG1592	Rubrerythrin
THMC_RS03365	COG2033	superoxide reductase activity
THMC_RS03370	COG1773	rubredoxin
THMC_RS03375	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
THMC_RS03385	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
THMC_RS03400	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
THMC_RS03405	COG1045	serine acetyltransferase
THMC_RS03410	COG0084	hydrolase, TatD family'
THMC_RS03450	COG1582	Flagellar protein (FlbD)
THMC_RS03460	COG1360	Flagellar Motor Protein
THMC_RS03470	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
THMC_RS03475	COG1776	CheC inhibitor of MCP methylation
THMC_RS03475	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
THMC_RS03505	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
THMC_RS03510	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
THMC_RS03515	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
THMC_RS03520	COG0149	triose-phosphate isomerase activity
THMC_RS03520	COG0126	phosphoglycerate kinase activity
THMC_RS03535	COG0736	holo-[acyl-carrier-protein] synthase activity
THMC_RS03545	COG0544	peptidyl-prolyl cis-trans isomerase activity
THMC_RS03550	COG0740	serine-type endopeptidase activity
THMC_RS03565	COG1338	Plays a role in the flagellum-specific transport system
THMC_RS03575	COG2201	protein-glutamate methylesterase activity
THMC_RS03580	COG0835	chemotaxis
THMC_RS03585	COG0643	Histidine kinase
THMC_RS03585	COG2198	Histidine kinase
THMC_RS03590	COG1058	Belongs to the CinA family
THMC_RS03590	COG1546	Belongs to the CinA family
THMC_RS03595	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
THMC_RS03600	COG1136	(ABC) transporter
THMC_RS03610	COG0357	Ribosomal RNA small subunit methyltransferase G
THMC_RS03615	COG0095	Lipoate-protein ligase
THMC_RS03620	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
THMC_RS03650	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
THMC_RS03650	COG3620	sequence-specific DNA binding
THMC_RS03650	COG0617	tRNA 3'-terminal CCA addition
THMC_RS03655	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
THMC_RS03665	COG0511	ligase activity, forming carbon-carbon bonds
THMC_RS03670	COG0835	chemotaxis
THMC_RS03675	COG0215	cysteine-tRNA ligase activity
THMC_RS03680	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
THMC_RS03685	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
THMC_RS03690	COG0557	exoribonuclease II activity
THMC_RS03710	COG0312	modulator of DNA gyrase
THMC_RS03715	COG0312	modulator of DNA gyrase
THMC_RS03730	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
THMC_RS03735	COG1490	D-aminoacyl-tRNA deacylase activity
THMC_RS03740	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
THMC_RS03755	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
THMC_RS03765	COG1482	cell wall glycoprotein biosynthetic process
THMC_RS03780	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
THMC_RS03780	COG2199	diguanylate cyclase activity
THMC_RS03785	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
THMC_RS03795	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
THMC_RS03805	COG0438	transferase activity, transferring glycosyl groups
THMC_RS03820	COG0793	Belongs to the peptidase S41A family
THMC_RS03825	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
THMC_RS03840	COG0572	uridine kinase
THMC_RS03850	COG1486	melibiose metabolic process
THMC_RS03855	COG2226	methyltransferase
THMC_RS03860	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
THMC_RS03865	COG0426	domain, Protein
THMC_RS03870	COG0463	Glycosyl transferase, family 2
THMC_RS03870	COG1216	Glycosyl transferase, family 2
THMC_RS03875	COG0463	Glycosyl transferase, family 2
THMC_RS03875	COG0457	Tetratricopeptide repeat
THMC_RS03900	COG0052	Belongs to the universal ribosomal protein uS2 family
THMC_RS03905	COG0393	Putative heavy-metal-binding
THMC_RS03915	COG1131	(ABC) transporter
THMC_RS03925	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
THMC_RS03930	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
THMC_RS03935	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
THMC_RS03940	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
THMC_RS03945	COG0470	DNA polymerase III
THMC_RS03950	COG1774	PSP1 C-terminal conserved region
THMC_RS03965	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
THMC_RS04025	COG1635	Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur
THMC_RS04030	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
THMC_RS04040	COG0351	phosphomethylpyrimidine kinase
THMC_RS04040	COG1992	Thiamine-phosphate synthase
THMC_RS04045	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
THMC_RS04050	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
THMC_RS04055	COG1131	(ABC) transporter
THMC_RS04075	COG2045	Belongs to the ComB family
THMC_RS04080	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
THMC_RS04085	COG1268	BioY protein
THMC_RS04090	COG2070	2-Nitropropane dioxygenase
THMC_RS04095	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
THMC_RS04100	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
THMC_RS04105	COG0504	CTP synthase activity
THMC_RS04110	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
THMC_RS04115	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
THMC_RS04125	COG0450	alkyl hydroperoxide reductase
THMC_RS04130	COG1846	Transcriptional regulator
THMC_RS04130	COG1940	carbohydrate kinase activity
THMC_RS04150	COG0395	ABC-type sugar transport system, permease component
THMC_RS04155	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
THMC_RS04165	COG0534	Mate efflux family protein
THMC_RS04185	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
THMC_RS04195	COG1979	alcohol dehydrogenase
THMC_RS04210	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
THMC_RS04210	COG0072	phenylalanine-tRNA ligase activity
THMC_RS04225	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
THMC_RS04235	COG3842	ATPase activity
THMC_RS04250	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
THMC_RS04255	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
THMC_RS04265	COG0187	DNA topoisomerase II activity
THMC_RS04275	COG0849	cell division
THMC_RS04280	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
THMC_RS04285	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
THMC_RS04295	COG0772	Belongs to the SEDS family
THMC_RS04310	COG2201	protein-glutamate methylesterase activity
THMC_RS04320	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
THMC_RS04325	COG4535	Mg2 and Co2 transporter CorC
THMC_RS04330	COG0295	cytidine deaminase activity
THMC_RS04335	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
THMC_RS04340	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
THMC_RS04345	COG0484	heat shock protein binding
THMC_RS04350	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
THMC_RS04355	COG1420	regulation of RNA biosynthetic process
THMC_RS04365	COG0009	L-threonylcarbamoyladenylate synthase
THMC_RS04370	COG5002	protein histidine kinase activity
THMC_RS04375	COG1639	'signal transduction protein
THMC_RS04380	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
THMC_RS04385	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
THMC_RS04390	COG0196	riboflavin kinase activity
THMC_RS04400	COG1862	Preprotein translocase
THMC_RS04405	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
THMC_RS04410	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
THMC_RS04420	COG0359	binds to the 23S rRNA
THMC_RS04425	COG1234	tRNA 3'-trailer cleavage
THMC_RS04455	COG0768	penicillin binding
THMC_RS04465	COG0275	rRNA processing
THMC_RS04470	COG0542	response to heat
THMC_RS04475	COG1214	PFAM Peptidase M22, glycoprotease
THMC_RS04485	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
THMC_RS04490	COG0148	phosphopyruvate hydratase activity
THMC_RS04495	COG0674	pyruvate-flavodoxin oxidoreductase activity
THMC_RS04495	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
THMC_RS04505	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
THMC_RS04510	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
THMC_RS04515	COG2873	o-acetylhomoserine
THMC_RS04520	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
THMC_RS04535	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
THMC_RS04540	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
THMC_RS04550	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
THMC_RS04555	COG0750	zinc metalloprotease
THMC_RS04560	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
THMC_RS04565	COG2239	Acts as a magnesium transporter
THMC_RS04570	COG1968	undecaprenyl-diphosphatase activity
THMC_RS04580	COG0297	glycogen (starch) synthase activity
THMC_RS04585	COG1085	galactose-1-phosphate uridylyltransferase
THMC_RS04590	COG2359	stage V sporulation protein S
THMC_RS04615	COG1191	sigma factor activity
THMC_RS04620	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
THMC_RS04625	COG1776	CheC inhibitor of MCP methylation
THMC_RS04635	COG0455	bacterial-type flagellum organization
THMC_RS04640	COG1419	protein localization to endoplasmic reticulum
THMC_RS04645	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
THMC_RS04650	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
THMC_RS04655	COG1684	flagellar biosynthetic protein fliR
THMC_RS04660	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
THMC_RS04670	COG3956	TIGRFAM MazG family protein
THMC_RS04675	COG1392	Phosphate transport regulator
THMC_RS04680	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
THMC_RS04690	COG0306	phosphate transporter
THMC_RS04695	COG0840	transmembrane signaling receptor activity
THMC_RS04715	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
THMC_RS04715	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
THMC_RS04730	COG0220	tRNA (guanine-N7-)-methyltransferase activity
THMC_RS04735	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
THMC_RS04740	COG1141	Ferredoxin
THMC_RS04750	COG3864	Putative metallopeptidase domain
THMC_RS04775	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
THMC_RS04780	COG0517	IMP dehydrogenase activity
THMC_RS04780	COG0516	GMP reductase activity
THMC_RS04785	COG0402	S-adenosylhomocysteine deaminase activity
THMC_RS04800	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
THMC_RS04825	COG0174	glutamine synthetase
THMC_RS04870	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
THMC_RS04875	COG3958	Transketolase
THMC_RS04880	COG3959	Transketolase, thiamine diphosphate binding domain
THMC_RS04885	COG1172	Belongs to the binding-protein-dependent transport system permease family
THMC_RS04890	COG1129	ABC transporter
THMC_RS04905	COG1869	D-ribose catabolic process
THMC_RS04910	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
THMC_RS04915	COG1704	LemA family
THMC_RS04930	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
THMC_RS04935	COG1691	(AIR) carboxylase
THMC_RS04940	COG1606	tRNA processing
THMC_RS04945	COG4974	Belongs to the 'phage' integrase family
THMC_RS04970	COG3706	GGDEF domain
THMC_RS04975	COG0840	transmembrane signaling receptor activity
THMC_RS04995	COG0425	Belongs to the sulfur carrier protein TusA family
THMC_RS05015	COG2391	methyltransferase activity
THMC_RS05020	COG0425	Belongs to the sulfur carrier protein TusA family
THMC_RS05025	COG2373	Large extracellular alpha-helical protein
THMC_RS05035	COG3234	Protein of unknown function (DUF1175)
THMC_RS05055	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
THMC_RS05105	COG1895	HEPN domain
THMC_RS05135	COG2207	Transcriptional regulator
THMC_RS05140	COG0667	Aldo Keto reductase
THMC_RS05150	COG0656	L-ascorbic acid biosynthetic process
THMC_RS05180	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
THMC_RS05205	COG2814	Major facilitator Superfamily
THMC_RS05245	COG1131	(ABC) transporter
THMC_RS05270	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
THMC_RS05270	COG0662	Cupin 2, conserved barrel domain protein
THMC_RS05275	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
THMC_RS05280	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
THMC_RS05280	COG0140	phosphoribosyl-ATP diphosphatase activity
THMC_RS05285	COG0107	imidazoleglycerol-phosphate synthase activity
THMC_RS05295	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
THMC_RS05305	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
THMC_RS05310	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
THMC_RS05320	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
THMC_RS05340	COG0850	regulation of cytokinetic process
THMC_RS05365	COG1555	photosystem II stabilization
THMC_RS05365	COG1596	polysaccharide export
THMC_RS05375	COG1137	ATPase activity
THMC_RS05385	COG1324	tolerance protein
THMC_RS05390	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
THMC_RS05400	COG2359	stage V sporulation protein S
THMC_RS05415	COG3250	beta-galactosidase activity
THMC_RS05420	COG4608	Belongs to the ABC transporter superfamily
THMC_RS05425	COG0444	Belongs to the ABC transporter superfamily
THMC_RS05430	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
THMC_RS05435	COG0601	transmembrane transport
THMC_RS05440	COG0747	negative chemotaxis
THMC_RS05445	COG1486	melibiose metabolic process
THMC_RS05450	COG1349	DNA-binding transcription factor activity
THMC_RS05460	COG4952	isomerase
THMC_RS05470	COG1070	Carbohydrate kinase
THMC_RS05490	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
THMC_RS05500	COG2264	protein methyltransferase activity
THMC_RS05505	COG0698	ribose 5-phosphate isomerase
THMC_RS05510	COG1366	Belongs to the anti-sigma-factor antagonist family
THMC_RS05515	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
THMC_RS05520	COG1371	PFAM Archease protein family (DUF101 UPF0211)
THMC_RS05525	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
THMC_RS05530	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
THMC_RS05530	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
THMC_RS05545	COG0569	domain protein
THMC_RS05555	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
THMC_RS05560	COG0124	histidyl-tRNA synthetase
THMC_RS05575	COG0018	arginyl-trna synthetase
THMC_RS05580	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
THMC_RS05585	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
THMC_RS05590	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
THMC_RS05595	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
THMC_RS05605	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
THMC_RS05615	COG0622	Phosphoesterase
THMC_RS05620	COG0571	ribonuclease III activity
THMC_RS05635	COG0651	ATP synthesis coupled electron transport
THMC_RS05715	COG1175	transmembrane transport
THMC_RS05725	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
THMC_RS05755	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
THMC_RS05760	COG0280	phosphate acetyltransferase
THMC_RS05765	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
THMC_RS05770	COG0714	Associated with various cellular activities
THMC_RS05810	COG0516	GMP reductase activity
THMC_RS05810	COG0517	IMP dehydrogenase activity
THMC_RS05815	COG0785	Cytochrome C biogenesis protein
THMC_RS05825	COG0840	transmembrane signaling receptor activity
THMC_RS05835	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
THMC_RS05835	COG2199	diguanylate cyclase activity
THMC_RS05845	COG0840	transmembrane signaling receptor activity
THMC_RS05860	COG0601	transmembrane transport
THMC_RS05865	COG0747	negative chemotaxis
THMC_RS05870	COG4608	Belongs to the ABC transporter superfamily
THMC_RS05875	COG0444	Belongs to the ABC transporter superfamily
THMC_RS05885	COG0363	glucosamine-6-phosphate deaminase activity
THMC_RS05890	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
THMC_RS05895	COG1983	PspC domain protein
THMC_RS05910	COG0010	Belongs to the arginase family
THMC_RS05925	COG2239	Acts as a magnesium transporter
THMC_RS05930	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
THMC_RS05935	COG2199	diguanylate cyclase activity
THMC_RS05945	COG1013	pyruvate-flavodoxin oxidoreductase activity
THMC_RS05950	COG0635	Involved in the biosynthesis of porphyrin-containing compound
THMC_RS05960	COG0058	SHG alpha-glucan phosphorylase activity
THMC_RS05965	COG1028	Short-chain dehydrogenase reductase Sdr
THMC_RS05980	COG1151	hydroxylamine reductase activity
THMC_RS06005	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
THMC_RS06010	COG0456	acetyltransferase
THMC_RS06015	COG1516	flagellar protein fliS
THMC_RS06025	COG0494	nUDIX hydrolase
THMC_RS06030	COG1196	nuclear chromosome segregation
THMC_RS06035	COG0667	Aldo Keto reductase
THMC_RS06045	COG1803	Methylglyoxal synthase
THMC_RS06055	COG0628	permease
THMC_RS06075	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
THMC_RS06080	COG1085	galactose-1-phosphate uridylyltransferase
THMC_RS06085	COG3345	alpha-galactosidase
THMC_RS06090	COG3250	beta-galactosidase activity
THMC_RS06095	COG0444	Belongs to the ABC transporter superfamily
THMC_RS06105	COG4608	Belongs to the ABC transporter superfamily
THMC_RS06110	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
THMC_RS06125	COG1609	Transcriptional regulator
THMC_RS06135	COG3833	ABC-type maltose transport systems, permease component
THMC_RS06140	COG1175	transmembrane transport
THMC_RS06145	COG2182	Extracellular solute-binding protein
THMC_RS06150	COG1863	multisubunit Na H antiporter MnhE subunit
THMC_RS06155	COG2212	antiporter activity
THMC_RS06170	COG2111	Na H antiporter
THMC_RS06170	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
THMC_RS06180	COG0651	ATP synthesis coupled electron transport
THMC_RS06185	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
THMC_RS06195	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
THMC_RS06200	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
THMC_RS06200	COG0649	NAD binding
THMC_RS06205	COG0649	NAD binding
THMC_RS06215	COG1609	Transcriptional regulator
THMC_RS06220	COG4608	Belongs to the ABC transporter superfamily
THMC_RS06225	COG0444	Belongs to the ABC transporter superfamily
THMC_RS06230	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
THMC_RS06235	COG0601	transmembrane transport
THMC_RS06240	COG4166	transmembrane transport
THMC_RS06245	COG1940	carbohydrate kinase activity
THMC_RS06250	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
THMC_RS06255	COG0747	negative chemotaxis
THMC_RS06270	COG0463	Glycosyl transferase, family 2
THMC_RS06275	COG0438	transferase activity, transferring glycosyl groups
THMC_RS06280	COG0383	alpha-mannosidase activity
THMC_RS06285	COG3842	ATPase activity
THMC_RS06310	COG0210	DNA helicase
THMC_RS06320	COG0012	GTP binding
THMC_RS06335	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
THMC_RS06340	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
THMC_RS06345	COG0047	phosphoribosylformylglycinamidine synthase activity
THMC_RS06350	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
THMC_RS06355	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
THMC_RS06360	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
THMC_RS06365	COG0138	bifunctional purine biosynthesis protein purh
THMC_RS06370	COG0151	Belongs to the GarS family
THMC_RS06385	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
THMC_RS06385	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
THMC_RS06390	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
THMC_RS06395	COG0436	Aminotransferase
THMC_RS06400	COG1132	(ABC) transporter
THMC_RS06415	COG0745	RESPONSE REGULATOR receiver
THMC_RS06420	COG0704	Plays a role in the regulation of phosphate uptake
THMC_RS06425	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
THMC_RS06440	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
THMC_RS06465	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
THMC_RS06470	COG0626	cystathionine gamma-synthase activity
THMC_RS06475	COG2165	general secretion pathway protein
THMC_RS06480	COG0154	amidase activity
THMC_RS06485	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
THMC_RS06500	COG3842	ATPase activity
THMC_RS06510	COG1193	negative regulation of DNA recombination
THMC_RS06525	COG1486	melibiose metabolic process
THMC_RS06530	COG0463	Glycosyl transferase, family 2
THMC_RS06540	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
THMC_RS06560	COG0662	Cupin 2, conserved barrel domain protein
THMC_RS06565	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
THMC_RS06565	COG0731	radical SAM domain protein
THMC_RS06580	COG2894	cell division
THMC_RS06585	COG0489	protein tyrosine kinase activity
THMC_RS06590	COG2226	methyltransferase
THMC_RS06600	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
THMC_RS06610	COG0667	Aldo Keto reductase
THMC_RS06630	COG4555	ABC transporter
THMC_RS06665	COG1132	(ABC) transporter
THMC_RS06670	COG1598	PFAM Uncharacterised protein family UPF0150
THMC_RS06680	COG1598	PFAM Uncharacterised protein family UPF0150
THMC_RS06685	COG0457	Tetratricopeptide repeat
THMC_RS06705	COG1132	(ABC) transporter
THMC_RS06710	COG1132	(ABC) transporter
THMC_RS06720	COG1598	PFAM Uncharacterised protein family UPF0150
THMC_RS06790	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
THMC_RS06800	COG0612	Peptidase, M16
THMC_RS06805	COG0517	IMP dehydrogenase activity
THMC_RS06805	COG0516	GMP reductase activity
THMC_RS06815	COG0628	permease
THMC_RS06820	COG2267	carboxylic ester hydrolase activity
THMC_RS06825	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
THMC_RS06840	COG0516	GMP reductase activity
THMC_RS06840	COG0517	IMP dehydrogenase activity
THMC_RS06865	COG3852	Histidine kinase
THMC_RS06870	COG0745	RESPONSE REGULATOR receiver
THMC_RS06875	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
THMC_RS06885	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
THMC_RS06890	COG1815	bacterial-type flagellum-dependent cell motility
THMC_RS06900	COG1677	Flagellar hook-basal body complex protein FliE
THMC_RS06915	COG0396	ATPase activity
THMC_RS06920	COG0719	Fe-S assembly protein
THMC_RS06930	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
THMC_RS06935	COG0822	iron-sulfur transferase activity
THMC_RS06945	COG0406	alpha-ribazole phosphatase activity
THMC_RS06955	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
THMC_RS06960	COG3842	ATPase activity
THMC_RS06965	COG1176	ABC-type spermidine putrescine transport system, permease component I
THMC_RS06970	COG1177	transmembrane transport
THMC_RS06975	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
THMC_RS06995	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
THMC_RS07000	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
THMC_RS07005	COG0166	Belongs to the GPI family
THMC_RS07015	COG0237	dephospho-CoA kinase activity
THMC_RS07020	COG0742	ribosomal rna small subunit methyltransferase
THMC_RS07025	COG2264	protein methyltransferase activity
THMC_RS07045	COG0542	response to heat
THMC_RS07055	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
THMC_RS07060	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
THMC_RS07070	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
THMC_RS07075	COG0575	Belongs to the CDS family
THMC_RS07080	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
THMC_RS07090	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
THMC_RS07095	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
THMC_RS07115	COG0438	transferase activity, transferring glycosyl groups
THMC_RS07140	COG2342	PFAM TM1410 hypothetical-related protein
THMC_RS07160	COG1621	beta-fructofuranosidase activity
THMC_RS07165	COG0483	inositol monophosphate 1-phosphatase activity
THMC_RS07175	COG0719	Fe-S assembly protein
THMC_RS07180	COG0396	ATPase activity
THMC_RS07185	COG1213	nucleotidyl transferase
THMC_RS07185	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
THMC_RS07200	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
THMC_RS07215	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
THMC_RS07230	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
THMC_RS07235	COG0840	transmembrane signaling receptor activity
THMC_RS07240	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
THMC_RS07250	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
THMC_RS07280	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
THMC_RS07285	COG1543	Belongs to the glycosyl hydrolase 57 family
THMC_RS07295	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
THMC_RS07295	COG2050	protein possibly involved in aromatic compounds catabolism
THMC_RS07300	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
THMC_RS07305	COG1366	Belongs to the anti-sigma-factor antagonist family
THMC_RS07310	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
THMC_RS07315	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
THMC_RS07325	COG1160	GTP binding
THMC_RS07330	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
THMC_RS07345	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
THMC_RS07350	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
THMC_RS07355	COG0358	DNA primase activity
THMC_RS07360	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
THMC_RS07365	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
THMC_RS07370	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
THMC_RS07375	COG0211	Belongs to the bacterial ribosomal protein bL27 family
THMC_RS07385	COG0261	This protein binds to 23S rRNA in the presence of protein L20
THMC_RS07400	COG0706	membrane insertase activity
THMC_RS07405	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
THMC_RS07410	COG0594	ribonuclease P activity
THMC_RS07415	COG0230	Belongs to the bacterial ribosomal protein bL34 family
THMC_RS07420	COG2313	pseudouridylate synthase activity
THMC_RS07425	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
THMC_RS07430	COG0218	Necessary for normal cell division and for the maintenance of normal septation
THMC_RS07435	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
THMC_RS07445	COG1307	EDD domain protein, DegV family
THMC_RS07455	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
THMC_RS07460	COG0203	ribosomal protein L17
THMC_RS07465	COG0202	RNA polymerase activity
THMC_RS07470	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
THMC_RS07475	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
THMC_RS07480	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
THMC_RS07485	COG0257	Belongs to the bacterial ribosomal protein bL36 family
THMC_RS07490	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
THMC_RS07500	COG0563	adenylate kinase activity
THMC_RS07505	COG0201	protein transport
THMC_RS07510	COG0200	Binds to the 23S rRNA
THMC_RS07515	COG1841	ribosomal large subunit assembly
THMC_RS07520	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
THMC_RS07525	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
THMC_RS07530	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
THMC_RS07535	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
THMC_RS07540	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
THMC_RS07545	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
THMC_RS07550	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
THMC_RS07555	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
THMC_RS07560	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
THMC_RS07565	COG0255	Belongs to the universal ribosomal protein uL29 family
THMC_RS07570	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
THMC_RS07575	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
THMC_RS07580	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
THMC_RS07585	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
THMC_RS07590	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
THMC_RS07595	COG0089	rRNA binding
THMC_RS07600	COG0088	Forms part of the polypeptide exit tunnel
THMC_RS07605	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
THMC_RS07610	COG0051	transcription antitermination factor activity, RNA binding
THMC_RS07615	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
THMC_RS07620	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
THMC_RS07625	COG0049	tRNA binding
THMC_RS07630	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
THMC_RS07640	COG1702	phosphate starvation-inducible protein PhoH
THMC_RS07645	COG1480	7TM receptor with intracellular HD hydrolase
THMC_RS07650	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
THMC_RS07660	COG2738	Putative neutral zinc metallopeptidase
THMC_RS07665	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
THMC_RS07665	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
THMC_RS07670	COG1323	Belongs to the UPF0348 family
THMC_RS07685	COG1473	amidohydrolase
THMC_RS07690	COG0019	diaminopimelate decarboxylase activity
THMC_RS07705	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
THMC_RS07710	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
THMC_RS07720	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
THMC_RS07750	COG1959	2 iron, 2 sulfur cluster binding
THMC_RS07755	COG1575	Belongs to the MenA family. Type 1 subfamily
THMC_RS07765	COG2086	electron transfer activity
THMC_RS07770	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
THMC_RS07775	COG0644	oxidoreductase
THMC_RS07800	COG1032	radical SAM domain protein
THMC_RS07810	COG1706	bacterial-type flagellum-dependent cell motility
THMC_RS07815	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
THMC_RS07830	COG4786	Flagellar basal body rod
THMC_RS07850	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
THMC_RS07850	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
THMC_RS07855	COG1078	dGTPase activity
THMC_RS07860	COG1086	Polysaccharide biosynthesis protein
THMC_RS07865	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
THMC_RS07870	COG3872	metal-dependent enzyme
THMC_RS07875	COG2078	PFAM AMMECR1 domain protein
THMC_RS07885	COG1477	protein flavinylation
THMC_RS07905	COG2003	Belongs to the UPF0758 family
THMC_RS07915	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
THMC_RS07925	COG0343	queuine tRNA-ribosyltransferase activity
THMC_RS07940	COG1254	Belongs to the acylphosphatase family
THMC_RS07945	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
THMC_RS07950	COG0228	four-way junction DNA binding
THMC_RS07955	COG1837	Belongs to the UPF0109 family
THMC_RS07960	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
THMC_RS07965	COG0336	Belongs to the RNA methyltransferase TrmD family
THMC_RS07970	COG4752	Belongs to the RNA methyltransferase TrmD family
THMC_RS07975	COG0335	large ribosomal subunit rRNA binding
THMC_RS07980	COG0681	Belongs to the peptidase S26 family
THMC_RS07990	COG0101	tRNA pseudouridine synthase activity
THMC_RS08000	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
THMC_RS08010	COG0653	protein targeting
THMC_RS08040	COG1040	competence protein
THMC_RS08045	COG2379	hydroxypyruvate reductase
THMC_RS08060	COG2203	Gaf domain
THMC_RS08060	COG2199	diguanylate cyclase activity
THMC_RS08095	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
THMC_RS08110	COG0489	protein tyrosine kinase activity
THMC_RS08120	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
THMC_RS08125	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
THMC_RS08135	COG1595	DNA-templated transcription, initiation
THMC_RS08150	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
THMC_RS08155	COG1827	regulation of RNA biosynthetic process
THMC_RS08160	COG0477	Major facilitator Superfamily
THMC_RS08165	COG0528	UMP kinase activity
THMC_RS08175	COG1530	ribonuclease E activity
THMC_RS08180	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
THMC_RS08185	COG1307	EDD domain protein, DegV family
THMC_RS08190	COG0355	proton-transporting ATP synthase activity, rotational mechanism
THMC_RS08195	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
THMC_RS08200	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
THMC_RS08205	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
THMC_RS08210	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
THMC_RS08215	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
THMC_RS08220	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
THMC_RS08225	COG0356	it plays a direct role in the translocation of protons across the membrane
THMC_RS08240	COG1406	Chemotaxis phosphatase CheX
THMC_RS08245	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
THMC_RS08245	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
THMC_RS08255	COG0584	glycerophosphoryl diester phosphodiesterase
THMC_RS08265	COG0481	GTPase activity
THMC_RS08270	COG3250	beta-galactosidase activity
THMC_RS08280	COG0193	aminoacyl-tRNA hydrolase activity
THMC_RS08285	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
THMC_RS08290	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
THMC_RS08295	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
THMC_RS08310	COG0802	atpase or kinase
THMC_RS08315	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
THMC_RS08325	COG0420	3'-5' exonuclease activity
THMC_RS08330	COG0419	ATPase involved in DNA repair
THMC_RS08340	COG4555	ABC transporter
THMC_RS08345	COG0543	2 iron, 2 sulfur cluster binding
THMC_RS08355	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
THMC_RS08360	COG0540	Belongs to the ATCase OTCase family
THMC_RS08360	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
THMC_RS08365	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
THMC_RS08370	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
THMC_RS08375	COG0157	Belongs to the NadC ModD family
THMC_RS08390	COG1713	HD superfamily hydrolase involved in NAD metabolism
THMC_RS08405	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
THMC_RS08420	COG5002	protein histidine kinase activity
THMC_RS08425	COG0745	RESPONSE REGULATOR receiver
THMC_RS08440	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
THMC_RS08455	COG0242	peptide deformylase activity
THMC_RS08460	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
THMC_RS08465	COG1122	ATPase activity
THMC_RS08470	COG2813	Specifically methylates the guanine in position
THMC_RS08480	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
THMC_RS08485	COG2115	Belongs to the xylose isomerase family
THMC_RS08515	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
THMC_RS08565	COG3437	response regulator, receiver
THMC_RS08570	COG1278	Cold shock
THMC_RS08575	COG0254	rRNA binding
THMC_RS08580	COG1185	polyribonucleotide nucleotidyltransferase activity
THMC_RS08585	COG1376	ErfK ybiS ycfS ynhG family protein
THMC_RS08590	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
THMC_RS08600	COG0194	GDP metabolic process
THMC_RS08605	COG2052	Domain of unknown function (DUF370)
THMC_RS08625	COG0301	tRNA thio-modification
THMC_RS08645	COG0436	Aminotransferase
THMC_RS08650	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
THMC_RS08660	COG0534	Mate efflux family protein
THMC_RS08670	COG1368	sulfuric ester hydrolase activity
THMC_RS08680	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
THMC_RS08685	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
THMC_RS08690	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
THMC_RS08700	COG0391	Required for morphogenesis under gluconeogenic growth conditions
THMC_RS08720	COG1739	Uncharacterized protein family UPF0029
THMC_RS08730	COG0820	rRNA (adenine-C2-)-methyltransferase activity
THMC_RS08740	COG1162	GTPase activity
THMC_RS08745	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
THMC_RS08750	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
THMC_RS08775	COG1028	Short-chain dehydrogenase reductase Sdr
THMC_RS08780	COG1394	ATPase activity, coupled to movement of substances
THMC_RS08795	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
THMC_RS08805	COG2255	four-way junction helicase activity
THMC_RS08810	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
THMC_RS08820	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
THMC_RS08825	COG0704	Plays a role in the regulation of phosphate uptake
THMC_RS08835	COG0305	Participates in initiation and elongation during chromosome replication
THMC_RS08840	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
THMC_RS08855	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
THMC_RS08860	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
THMC_RS08865	COG0647	UMP catabolic process
THMC_RS08870	COG0667	Aldo Keto reductase
THMC_RS08890	COG0601	transmembrane transport
THMC_RS08895	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
THMC_RS08905	COG4608	Belongs to the ABC transporter superfamily
THMC_RS08910	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
THMC_RS08920	COG0556	nucleotide-excision repair
THMC_RS08925	COG3426	butyrate kinase activity
THMC_RS08930	COG0280	phosphate acetyltransferase
THMC_RS08935	COG3426	butyrate kinase activity
THMC_RS08970	COG0556	nucleotide-excision repair
THMC_RS08980	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
THMC_RS08990	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
THMC_RS08995	COG2759	Belongs to the formate--tetrahydrofolate ligase family
THMC_RS09000	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
THMC_RS09005	COG1570	exodeoxyribonuclease VII activity
THMC_RS09010	COG1722	exodeoxyribonuclease VII activity
THMC_RS09015	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
THMC_RS09035	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
THMC_RS09045	COG0735	belongs to the Fur family
THMC_RS09050	COG0195	Participates in both transcription termination and antitermination
THMC_RS09055	COG0779	Required for maturation of 30S ribosomal subunits
THMC_RS09065	COG0137	argininosuccinate synthase activity
THMC_RS09070	COG0165	Argininosuccinate lyase
THMC_RS09075	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
THMC_RS09080	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
THMC_RS09085	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
THMC_RS09090	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
THMC_RS09130	COG3337	CRISPR-associated protein (Cas_Cmr5)
THMC_RS09155	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
THMC_RS09160	COG1518	maintenance of DNA repeat elements
THMC_RS09190	COG0484	heat shock protein binding
THMC_RS09220	COG1337	RAMP superfamily
THMC_RS09230	COG1353	crispr-associated protein
THMC_RS09255	COG0525	valine-tRNA ligase activity
THMC_RS09260	COG2059	Chromate
THMC_RS09275	COG1059	Responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine 7-oxoG) from DNA. Also nicks DNA at apurinic apyrimidinic sites (AP sites)
THMC_RS09280	COG0330	HflC and HflK could
THMC_RS09285	COG0330	HflC and HflK could
THMC_RS09300	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
THMC_RS09300	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
THMC_RS09305	COG0307	riboflavin synthase, alpha
THMC_RS09310	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
THMC_RS09310	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
THMC_RS09315	COG3706	GGDEF domain
THMC_RS09330	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
THMC_RS09335	COG1486	melibiose metabolic process
THMC_RS09340	COG0366	Alpha amylase catalytic
THMC_RS09345	COG3833	ABC-type maltose transport systems, permease component
THMC_RS09350	COG1175	transmembrane transport
THMC_RS09355	COG2182	Extracellular solute-binding protein
THMC_RS09360	COG0366	Alpha amylase catalytic
THMC_RS09385	COG1523	belongs to the glycosyl hydrolase 13 family
THMC_RS09395	COG1940	carbohydrate kinase activity
THMC_RS09400	COG1129	ABC transporter
THMC_RS09405	COG1172	Belongs to the binding-protein-dependent transport system permease family
THMC_RS09425	COG1653	transport
THMC_RS09430	COG2723	6-phospho-beta-galactosidase activity
THMC_RS09435	COG3459	Glycosyltransferase 36 associated
THMC_RS09460	COG0395	ABC-type sugar transport system, permease component
THMC_RS09475	COG1609	Transcriptional regulator
THMC_RS09480	COG1418	mRNA catabolic process
THMC_RS09490	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
THMC_RS09495	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
THMC_RS09500	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
THMC_RS09505	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
THMC_RS09520	COG1515	deoxyribonuclease V activity
THMC_RS09530	COG0039	L-malate dehydrogenase activity
THMC_RS09535	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
THMC_RS09540	COG1067	ATP-dependent peptidase activity
THMC_RS09545	COG2894	cell division
THMC_RS09555	COG0432	Pfam Uncharacterised protein family UPF0047
THMC_RS09565	COG1278	Cold shock
THMC_RS09570	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
THMC_RS09575	COG0622	Phosphoesterase
THMC_RS09585	COG0737	Belongs to the 5'-nucleotidase family