locus-tag	class	description
TNAP_RS00010	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
TNAP_RS00015	COG0220	tRNA (guanine-N7-)-methyltransferase activity
TNAP_RS00030	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
TNAP_RS00030	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
TNAP_RS00035	COG0741	lytic transglycosylase activity
TNAP_RS00050	COG0840	transmembrane signaling receptor activity
TNAP_RS00055	COG0306	phosphate transporter
TNAP_RS00065	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
TNAP_RS00070	COG1392	Phosphate transport regulator
TNAP_RS00075	COG3956	TIGRFAM MazG family protein
TNAP_RS00085	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
TNAP_RS00090	COG1684	flagellar biosynthetic protein fliR
TNAP_RS00095	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
TNAP_RS00100	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
TNAP_RS00105	COG1419	protein localization to endoplasmic reticulum
TNAP_RS00110	COG0455	bacterial-type flagellum organization
TNAP_RS00120	COG1776	CheC inhibitor of MCP methylation
TNAP_RS00125	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
TNAP_RS00130	COG1191	sigma factor activity
TNAP_RS00155	COG2359	stage V sporulation protein S
TNAP_RS00160	COG1085	galactose-1-phosphate uridylyltransferase
TNAP_RS00165	COG0297	glycogen (starch) synthase activity
TNAP_RS00175	COG1968	undecaprenyl-diphosphatase activity
TNAP_RS00180	COG2239	Acts as a magnesium transporter
TNAP_RS00185	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
TNAP_RS00190	COG0750	zinc metalloprotease
TNAP_RS00195	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
TNAP_RS00205	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
TNAP_RS00210	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
TNAP_RS00230	COG2873	o-acetylhomoserine
TNAP_RS00235	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
TNAP_RS00240	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
TNAP_RS00250	COG0674	pyruvate-flavodoxin oxidoreductase activity
TNAP_RS00250	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
TNAP_RS00255	COG0148	phosphopyruvate hydratase activity
TNAP_RS00260	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
TNAP_RS00270	COG1214	PFAM Peptidase M22, glycoprotease
TNAP_RS00275	COG0542	response to heat
TNAP_RS00280	COG0275	rRNA processing
TNAP_RS00290	COG0768	penicillin binding
TNAP_RS00295	COG0492	ferredoxin-NADP+ reductase activity
TNAP_RS00320	COG1234	tRNA 3'-trailer cleavage
TNAP_RS00325	COG0359	binds to the 23S rRNA
TNAP_RS00335	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
TNAP_RS00340	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
TNAP_RS00345	COG1862	Preprotein translocase
TNAP_RS00360	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
TNAP_RS00365	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
TNAP_RS00370	COG1639	'signal transduction protein
TNAP_RS00375	COG5002	protein histidine kinase activity
TNAP_RS00380	COG0009	L-threonylcarbamoyladenylate synthase
TNAP_RS00405	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
TNAP_RS00410	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
TNAP_RS00415	COG0295	cytidine deaminase activity
TNAP_RS00420	COG4535	Mg2 and Co2 transporter CorC
TNAP_RS00425	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
TNAP_RS00435	COG4565	transcriptional regulatory protein
TNAP_RS00450	COG0772	Belongs to the SEDS family
TNAP_RS00460	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
TNAP_RS00465	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
TNAP_RS00470	COG0849	cell division
TNAP_RS00480	COG0187	DNA topoisomerase II activity
TNAP_RS00490	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
TNAP_RS00495	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TNAP_RS00510	COG3842	ATPase activity
TNAP_RS00515	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
TNAP_RS00530	COG0072	phenylalanine-tRNA ligase activity
TNAP_RS00530	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TNAP_RS00535	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
TNAP_RS00545	COG1979	alcohol dehydrogenase
TNAP_RS00555	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
TNAP_RS00580	COG0534	Mate efflux family protein
TNAP_RS00590	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
TNAP_RS00595	COG0395	ABC-type sugar transport system, permease component
TNAP_RS00610	COG1472	Belongs to the glycosyl hydrolase 3 family
TNAP_RS00615	COG1940	carbohydrate kinase activity
TNAP_RS00615	COG1846	Transcriptional regulator
TNAP_RS00620	COG0450	alkyl hydroperoxide reductase
TNAP_RS00630	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
TNAP_RS00635	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
TNAP_RS00640	COG0504	CTP synthase activity
TNAP_RS00645	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
TNAP_RS00650	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
TNAP_RS00655	COG2070	2-Nitropropane dioxygenase
TNAP_RS00660	COG1268	BioY protein
TNAP_RS00665	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
TNAP_RS00670	COG2045	Belongs to the ComB family
TNAP_RS00695	COG1131	(ABC) transporter
TNAP_RS00700	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
TNAP_RS00705	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
TNAP_RS00710	COG1992	Thiamine-phosphate synthase
TNAP_RS00710	COG0351	phosphomethylpyrimidine kinase
TNAP_RS00720	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
TNAP_RS00725	COG1635	Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur
TNAP_RS00735	COG1659	Linocin_M18 bacteriocin protein
TNAP_RS00780	COG3956	TIGRFAM MazG family protein
TNAP_RS00800	COG0366	Alpha amylase catalytic
TNAP_RS00805	COG1362	aminopeptidase activity
TNAP_RS00810	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
TNAP_RS00820	COG0840	transmembrane signaling receptor activity
TNAP_RS00835	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
TNAP_RS00840	COG1438	arginine binding
TNAP_RS00850	COG0443	Heat shock 70 kDa protein
TNAP_RS00855	COG0071	Belongs to the small heat shock protein (HSP20) family
TNAP_RS00860	COG4869	propanediol catabolic process
TNAP_RS00865	COG0730	response to heat
TNAP_RS00870	COG1131	(ABC) transporter
TNAP_RS00885	COG0778	Nitroreductase
TNAP_RS00900	COG0778	Nitroreductase
TNAP_RS00905	COG1194	a g-specific adenine glycosylase
TNAP_RS00920	COG0446	pyridine nucleotide-disulphide oxidoreductase
TNAP_RS00925	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
TNAP_RS00935	COG0438	transferase activity, transferring glycosyl groups
TNAP_RS00955	COG0493	'glutamate synthase
TNAP_RS00955	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
TNAP_RS00965	COG0067	glutamate synthase
TNAP_RS00980	COG3850	Histidine kinase
TNAP_RS00980	COG5002	protein histidine kinase activity
TNAP_RS00985	COG1435	thymidine kinase activity
TNAP_RS00990	COG0004	ammonium transporteR
TNAP_RS00995	COG0347	Belongs to the P(II) protein family
TNAP_RS01005	COG1013	pyruvate-flavodoxin oxidoreductase activity
TNAP_RS01020	COG2201	protein-glutamate methylesterase activity
TNAP_RS01025	COG0739	heme binding
TNAP_RS01040	COG1063	alcohol dehydrogenase
TNAP_RS01045	COG1402	creatininase
TNAP_RS01050	COG0673	inositol 2-dehydrogenase activity
TNAP_RS01060	COG1082	Xylose isomerase domain protein TIM barrel
TNAP_RS01070	COG1175	transmembrane transport
TNAP_RS01075	COG3833	ABC-type maltose transport systems, permease component
TNAP_RS01080	COG3842	ATPase activity
TNAP_RS01085	COG1082	Xylose isomerase domain protein TIM barrel
TNAP_RS01095	COG1172	Belongs to the binding-protein-dependent transport system permease family
TNAP_RS01105	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
TNAP_RS01120	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
TNAP_RS01125	COG1802	Transcriptional regulator
TNAP_RS01135	COG1028	Short-chain dehydrogenase reductase Sdr
TNAP_RS01145	COG1070	Carbohydrate kinase
TNAP_RS01150	COG1027	Aspartate ammonia-lyase
TNAP_RS01155	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
TNAP_RS01160	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
TNAP_RS01165	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
TNAP_RS01170	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
TNAP_RS01175	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
TNAP_RS01200	COG0267	Belongs to the bacterial ribosomal protein bL33 family
TNAP_RS01210	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
TNAP_RS01215	COG0250	Participates in transcription elongation, termination and antitermination
TNAP_RS01220	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
TNAP_RS01225	COG0081	regulation of translation
TNAP_RS01230	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
TNAP_RS01235	COG0222	ribosome binding
TNAP_RS01240	COG0085	RNA polymerase activity
TNAP_RS01245	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
TNAP_RS01250	COG0747	negative chemotaxis
TNAP_RS01255	COG0587	DNA-directed DNA polymerase activity
TNAP_RS01260	COG0564	pseudouridine synthase activity
TNAP_RS01265	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
TNAP_RS01275	COG0217	transcriptional regulatory protein
TNAP_RS01285	COG0745	RESPONSE REGULATOR receiver
TNAP_RS01305	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
TNAP_RS01310	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
TNAP_RS01320	COG1335	isochorismatase
TNAP_RS01335	COG1196	nuclear chromosome segregation
TNAP_RS01340	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
TNAP_RS01345	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
TNAP_RS01350	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
TNAP_RS01380	COG1116	anion transmembrane transporter activity
TNAP_RS01385	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
TNAP_RS01390	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
TNAP_RS01400	COG2151	metal-sulfur cluster biosynthetic enzyme
TNAP_RS01405	COG2890	protein-(glutamine-N5) methyltransferase activity
TNAP_RS01415	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
TNAP_RS01425	COG0180	Tryptophanyl-tRNA synthetase
TNAP_RS01435	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
TNAP_RS01440	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
TNAP_RS01445	COG2176	DNA-directed DNA polymerase activity
TNAP_RS01455	COG0444	Belongs to the ABC transporter superfamily
TNAP_RS01465	COG4608	Belongs to the ABC transporter superfamily
TNAP_RS01470	COG0444	Belongs to the ABC transporter superfamily
TNAP_RS01475	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TNAP_RS01480	COG0601	transmembrane transport
TNAP_RS01485	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
TNAP_RS01490	COG0459	protein refolding
TNAP_RS01495	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
TNAP_RS01495	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
TNAP_RS01510	COG1573	uracil-dna glycosylase
TNAP_RS01520	COG0606	chelatase, subunit chli
TNAP_RS01525	COG0442	prolyl-tRNA aminoacylation
TNAP_RS01530	COG1242	4 iron, 4 sulfur cluster binding
TNAP_RS01555	COG0482	sulfurtransferase activity
TNAP_RS01560	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
TNAP_RS01565	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
TNAP_RS01585	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
TNAP_RS01590	COG1923	regulation of RNA biosynthetic process
TNAP_RS01595	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
TNAP_RS01600	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
TNAP_RS01610	COG4608	Belongs to the ABC transporter superfamily
TNAP_RS01615	COG0747	negative chemotaxis
TNAP_RS01620	COG0601	transmembrane transport
TNAP_RS01625	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TNAP_RS01630	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
TNAP_RS01645	COG4717	serine-type aminopeptidase activity
TNAP_RS01655	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
TNAP_RS01665	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
TNAP_RS01665	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
TNAP_RS01680	COG1131	(ABC) transporter
TNAP_RS01685	COG0083	homoserine kinase activity
TNAP_RS01690	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
TNAP_RS01695	COG0527	aspartate kinase activity
TNAP_RS01700	COG0028	Belongs to the TPP enzyme family
TNAP_RS01705	COG0440	acetolactate synthase activity
TNAP_RS01715	COG0129	dihydroxy-acid dehydratase activity
TNAP_RS01720	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
TNAP_RS01730	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
TNAP_RS01735	COG0066	3-isopropylmalate dehydratase activity
TNAP_RS01740	COG0473	3-isopropylmalate dehydrogenase activity
TNAP_RS01745	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
TNAP_RS01750	COG0505	Belongs to the CarA family
TNAP_RS01765	COG0598	Magnesium transport protein CorA
TNAP_RS01770	COG1181	Belongs to the D-alanine--D-alanine ligase family
TNAP_RS01795	COG1489	DNA binding
TNAP_RS01805	COG1959	2 iron, 2 sulfur cluster binding
TNAP_RS01820	COG0552	protein localization to endoplasmic reticulum
TNAP_RS01825	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TNAP_RS01830	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
TNAP_RS01835	COG0815	Transfers the fatty acyl group on membrane lipoproteins
TNAP_RS01840	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
TNAP_RS01845	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
TNAP_RS01850	COG2176	DNA-directed DNA polymerase activity
TNAP_RS01855	COG0456	acetyltransferase
TNAP_RS01860	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
TNAP_RS01875	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
TNAP_RS01900	COG0673	inositol 2-dehydrogenase activity
TNAP_RS01905	COG0697	spore germination
TNAP_RS01910	COG0517	IMP dehydrogenase activity
TNAP_RS01910	COG1227	inorganic diphosphatase activity
TNAP_RS01915	COG1077	Cell shape determining protein MreB Mrl
TNAP_RS01930	COG0768	penicillin binding
TNAP_RS01940	COG0765	amino acid transport
TNAP_RS01945	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
TNAP_RS01950	COG2252	PERMEase
TNAP_RS01960	COG1175	transmembrane transport
TNAP_RS01965	COG0395	ABC-type sugar transport system, permease component
TNAP_RS01990	COG0360	Binds together with S18 to 16S ribosomal RNA
TNAP_RS01995	COG0629	single-stranded DNA binding
TNAP_RS02000	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
TNAP_RS02010	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TNAP_RS02070	COG1337	RAMP superfamily
TNAP_RS02095	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
TNAP_RS02095	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
TNAP_RS02100	COG0297	glycogen (starch) synthase activity
TNAP_RS02100	COG0438	transferase activity, transferring glycosyl groups
TNAP_RS02110	COG1442	glycosyl transferase family 8
TNAP_RS02110	COG1216	Glycosyl transferase, family 2
TNAP_RS02130	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
TNAP_RS02135	COG1083	cytidylyl-transferase
TNAP_RS02140	COG2089	acid synthase
TNAP_RS02145	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
TNAP_RS02155	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
TNAP_RS02195	COG0438	transferase activity, transferring glycosyl groups
TNAP_RS02195	COG0297	glycogen (starch) synthase activity
TNAP_RS02220	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
TNAP_RS02225	COG3951	Flagellar rod assembly protein muramidase FlgJ
TNAP_RS02225	COG1705	Flagellar rod assembly protein muramidase FlgJ
TNAP_RS02250	COG1596	polysaccharide export
TNAP_RS02260	COG1011	Hydrolase
TNAP_RS02275	COG0489	protein tyrosine kinase activity
TNAP_RS02275	COG3206	protein involved in exopolysaccharide biosynthesis
TNAP_RS02280	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
TNAP_RS02285	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
TNAP_RS02300	COG0561	phosphatase activity
TNAP_RS02310	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TNAP_RS02315	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
TNAP_RS02320	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
TNAP_RS02325	COG1476	TRANSCRIPTIONal
TNAP_RS02330	COG1592	Rubrerythrin
TNAP_RS02335	COG2033	superoxide reductase activity
TNAP_RS02340	COG1773	rubredoxin
TNAP_RS02345	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
TNAP_RS02355	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
TNAP_RS02370	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
TNAP_RS02375	COG1045	serine acetyltransferase
TNAP_RS02380	COG0084	hydrolase, TatD family'
TNAP_RS02415	COG1749	Flagellar hook protein flgE
TNAP_RS02420	COG1582	Flagellar protein (FlbD)
TNAP_RS02430	COG1360	Flagellar Motor Protein
TNAP_RS02440	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
TNAP_RS02445	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
TNAP_RS02445	COG1776	CheC inhibitor of MCP methylation
TNAP_RS02475	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
TNAP_RS02480	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
TNAP_RS02485	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
TNAP_RS02490	COG0126	phosphoglycerate kinase activity
TNAP_RS02495	COG0126	phosphoglycerate kinase activity
TNAP_RS02495	COG0149	triose-phosphate isomerase activity
TNAP_RS02510	COG0736	holo-[acyl-carrier-protein] synthase activity
TNAP_RS02520	COG0544	peptidyl-prolyl cis-trans isomerase activity
TNAP_RS02525	COG0740	serine-type endopeptidase activity
TNAP_RS02540	COG1338	Plays a role in the flagellum-specific transport system
TNAP_RS02550	COG2201	protein-glutamate methylesterase activity
TNAP_RS02555	COG0835	chemotaxis
TNAP_RS02560	COG2198	Histidine kinase
TNAP_RS02560	COG0643	Histidine kinase
TNAP_RS02565	COG1546	Belongs to the CinA family
TNAP_RS02565	COG1058	Belongs to the CinA family
TNAP_RS02570	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
TNAP_RS02575	COG1136	(ABC) transporter
TNAP_RS02585	COG0357	Ribosomal RNA small subunit methyltransferase G
TNAP_RS02590	COG0095	Lipoate-protein ligase
TNAP_RS02595	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
TNAP_RS02625	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
TNAP_RS02625	COG0617	tRNA 3'-terminal CCA addition
TNAP_RS02625	COG3620	sequence-specific DNA binding
TNAP_RS02630	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
TNAP_RS02640	COG0511	ligase activity, forming carbon-carbon bonds
TNAP_RS02640	COG5016	pyruvate
TNAP_RS02645	COG0835	chemotaxis
TNAP_RS02650	COG0215	cysteine-tRNA ligase activity
TNAP_RS02655	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
TNAP_RS02660	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
TNAP_RS02665	COG0557	exoribonuclease II activity
TNAP_RS02685	COG0312	modulator of DNA gyrase
TNAP_RS02690	COG0312	modulator of DNA gyrase
TNAP_RS02705	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
TNAP_RS02710	COG1490	D-aminoacyl-tRNA deacylase activity
TNAP_RS02715	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
TNAP_RS02730	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
TNAP_RS02740	COG1482	cell wall glycoprotein biosynthetic process
TNAP_RS02755	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
TNAP_RS02755	COG2199	diguanylate cyclase activity
TNAP_RS02760	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
TNAP_RS02770	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
TNAP_RS02780	COG0438	transferase activity, transferring glycosyl groups
TNAP_RS02795	COG0793	Belongs to the peptidase S41A family
TNAP_RS02800	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
TNAP_RS02815	COG0572	uridine kinase
TNAP_RS02825	COG1486	melibiose metabolic process
TNAP_RS02830	COG2226	methyltransferase
TNAP_RS02835	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
TNAP_RS02840	COG0426	domain, Protein
TNAP_RS02845	COG1216	Glycosyl transferase, family 2
TNAP_RS02845	COG0463	Glycosyl transferase, family 2
TNAP_RS02850	COG0457	Tetratricopeptide repeat
TNAP_RS02850	COG0463	Glycosyl transferase, family 2
TNAP_RS02875	COG0052	Belongs to the universal ribosomal protein uS2 family
TNAP_RS02890	COG1131	(ABC) transporter
TNAP_RS02900	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
TNAP_RS02905	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
TNAP_RS02910	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
TNAP_RS02915	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TNAP_RS02925	COG1774	PSP1 C-terminal conserved region
TNAP_RS02940	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
TNAP_RS02955	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
TNAP_RS02960	COG1486	melibiose metabolic process
TNAP_RS02970	COG4608	Belongs to the ABC transporter superfamily
TNAP_RS02975	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TNAP_RS02980	COG0601	transmembrane transport
TNAP_RS02990	COG0366	Alpha amylase catalytic
TNAP_RS02995	COG3833	ABC-type maltose transport systems, permease component
TNAP_RS03000	COG1175	transmembrane transport
TNAP_RS03005	COG2182	Extracellular solute-binding protein
TNAP_RS03010	COG0366	Alpha amylase catalytic
TNAP_RS03030	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
TNAP_RS03035	COG1523	belongs to the glycosyl hydrolase 13 family
TNAP_RS03045	COG1940	carbohydrate kinase activity
TNAP_RS03050	COG1129	ABC transporter
TNAP_RS03055	COG1172	Belongs to the binding-protein-dependent transport system permease family
TNAP_RS03075	COG1653	transport
TNAP_RS03085	COG2723	6-phospho-beta-galactosidase activity
TNAP_RS03090	COG3459	Glycosyltransferase 36 associated
TNAP_RS03115	COG0395	ABC-type sugar transport system, permease component
TNAP_RS03120	COG1175	transmembrane transport
TNAP_RS03145	COG1418	mRNA catabolic process
TNAP_RS03150	COG2137	regulation of response to DNA damage stimulus
TNAP_RS03155	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
TNAP_RS03160	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
TNAP_RS03165	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
TNAP_RS03195	COG0039	L-malate dehydrogenase activity
TNAP_RS03200	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
TNAP_RS03205	COG1067	ATP-dependent peptidase activity
TNAP_RS03210	COG2894	cell division
TNAP_RS03220	COG0432	Pfam Uncharacterised protein family UPF0047
TNAP_RS03230	COG1278	Cold shock
TNAP_RS03235	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
TNAP_RS03240	COG0622	Phosphoesterase
TNAP_RS03250	COG0737	Belongs to the 5'-nucleotidase family
TNAP_RS03260	COG4948	Mandelate Racemase Muconate Lactonizing
TNAP_RS03270	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
TNAP_RS03305	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
TNAP_RS03310	COG1144	Oxidoreductase
TNAP_RS03315	COG0674	pyruvate-flavodoxin oxidoreductase activity
TNAP_RS03320	COG1013	pyruvate-flavodoxin oxidoreductase activity
TNAP_RS03325	COG1028	Short-chain dehydrogenase reductase Sdr
TNAP_RS03330	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
TNAP_RS03335	COG1993	acr, cog1993
TNAP_RS03340	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
TNAP_RS03345	COG0840	transmembrane signaling receptor activity
TNAP_RS03355	COG1472	Belongs to the glycosyl hydrolase 3 family
TNAP_RS03365	COG4608	Belongs to the ABC transporter superfamily
TNAP_RS03370	COG0444	Belongs to the ABC transporter superfamily
TNAP_RS03380	COG0601	transmembrane transport
TNAP_RS03385	COG4166	transmembrane transport
TNAP_RS03415	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
TNAP_RS03415	COG2199	diguanylate cyclase activity
TNAP_RS03420	COG0720	synthase
TNAP_RS03430	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
TNAP_RS03435	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
TNAP_RS03435	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
TNAP_RS03440	COG0006	proline dipeptidase activity
TNAP_RS03445	COG1132	(ABC) transporter
TNAP_RS03460	COG0675	Transposase, IS605 OrfB family
TNAP_RS03470	COG2006	4fe-4S ferredoxin, iron-sulfur binding domain protein
TNAP_RS03480	COG1918	ferrous iron import across plasma membrane
TNAP_RS03480	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
TNAP_RS03500	COG3661	Belongs to the glycosyl hydrolase 67 family
TNAP_RS03505	COG0747	negative chemotaxis
TNAP_RS03510	COG4608	Belongs to the ABC transporter superfamily
TNAP_RS03515	COG0444	Belongs to the ABC transporter superfamily
TNAP_RS03520	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TNAP_RS03525	COG0601	transmembrane transport
TNAP_RS03530	COG3693	PFAM glycoside hydrolase, family 10
TNAP_RS03550	COG1414	Transcriptional regulator
TNAP_RS03555	COG0800	Aldolase
TNAP_RS03560	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
TNAP_RS03565	COG0246	Mannitol dehydrogenase
TNAP_RS03570	COG1312	Catalyzes the dehydration of D-mannonate
TNAP_RS03580	COG4166	transmembrane transport
TNAP_RS03585	COG0601	transmembrane transport
TNAP_RS03590	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TNAP_RS03595	COG0444	Belongs to the ABC transporter superfamily
TNAP_RS03600	COG4608	Belongs to the ABC transporter superfamily
TNAP_RS03605	COG1472	Belongs to the glycosyl hydrolase 3 family
TNAP_RS03610	COG3458	cephalosporin-C deacetylase activity
TNAP_RS03615	COG1120	ATPase activity
TNAP_RS03620	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TNAP_RS03625	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
TNAP_RS03630	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
TNAP_RS03635	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
TNAP_RS03655	COG0728	peptidoglycan biosynthetic process
TNAP_RS03660	COG1355	regulation of microtubule-based process
TNAP_RS03695	COG1459	type II secretion system
TNAP_RS03700	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
TNAP_RS03705	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
TNAP_RS03705	COG3116	cell division
TNAP_RS03710	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
TNAP_RS03715	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
TNAP_RS03725	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
TNAP_RS03735	COG1744	ABC transporter substrate-binding protein PnrA-like
TNAP_RS03740	COG3845	ABC transporter
TNAP_RS03745	COG4603	Belongs to the binding-protein-dependent transport system permease family
TNAP_RS03750	COG1079	Belongs to the binding-protein-dependent transport system permease family
TNAP_RS03765	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
TNAP_RS03775	COG1940	carbohydrate kinase activity
TNAP_RS03785	COG1172	Belongs to the binding-protein-dependent transport system permease family
TNAP_RS03800	COG1129	ABC transporter
TNAP_RS03805	COG1070	Carbohydrate kinase
TNAP_RS03825	COG0778	Nitroreductase
TNAP_RS03830	COG1509	lysine 2,3-aminomutase activity
TNAP_RS03840	COG0803	Belongs to the bacterial solute-binding protein 9 family
TNAP_RS03845	COG1121	(ABC) transporter
TNAP_RS03850	COG1108	ABC-type Mn2 Zn2 transport systems permease components
TNAP_RS03880	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
TNAP_RS03885	COG1335	isochorismatase
TNAP_RS03890	COG0492	ferredoxin-NADP+ reductase activity
TNAP_RS03900	COG0820	rRNA (adenine-C2-)-methyltransferase activity
TNAP_RS03905	COG0159	tryptophan synthase activity
TNAP_RS03910	COG0133	tryptophan synthase activity
TNAP_RS03915	COG0135	phosphoribosylanthranilate isomerase activity
TNAP_RS03920	COG0134	indole-3-glycerol-phosphate synthase activity
TNAP_RS03925	COG0512	Glutamine amidotransferase of anthranilate synthase
TNAP_RS03925	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
TNAP_RS03930	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
TNAP_RS03950	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
TNAP_RS03955	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
TNAP_RS03960	COG0799	negative regulation of ribosome biogenesis
TNAP_RS03965	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
TNAP_RS03970	COG0416	fatty acid biosynthetic process
TNAP_RS03975	COG0333	Belongs to the bacterial ribosomal protein bL32 family
TNAP_RS04000	COG1785	Belongs to the alkaline phosphatase family
TNAP_RS04015	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
TNAP_RS04020	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
TNAP_RS04050	COG0632	four-way junction helicase activity
TNAP_RS04055	COG0285	dihydrofolate synthase activity
TNAP_RS04060	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
TNAP_RS04065	COG0495	leucyl-tRNA aminoacylation
TNAP_RS04070	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
TNAP_RS04080	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
TNAP_RS04085	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
TNAP_RS04090	COG1110	DNA topoisomerase II activity
TNAP_RS04095	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
TNAP_RS04100	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
TNAP_RS04110	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
TNAP_RS04115	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
TNAP_RS04160	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TNAP_RS04170	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
TNAP_RS04200	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
TNAP_RS04210	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
TNAP_RS04215	COG2359	stage V sporulation protein S
TNAP_RS04240	COG0390	transport system, permease component
TNAP_RS04245	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
TNAP_RS04270	COG0037	tRNA processing
TNAP_RS04275	COG0542	response to heat
TNAP_RS04280	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
TNAP_RS04285	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
TNAP_RS04310	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
TNAP_RS04315	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
TNAP_RS04320	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
TNAP_RS04325	COG0469	pyruvate kinase activity
TNAP_RS04330	COG0205	6-phosphofructokinase activity
TNAP_RS04340	COG0404	The glycine cleavage system catalyzes the degradation of glycine
TNAP_RS04345	COG0509	glycine decarboxylation via glycine cleavage system
TNAP_RS04350	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
TNAP_RS04355	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
TNAP_RS04360	COG0251	oxidation-reduction process
TNAP_RS04365	COG0752	glycyl-tRNA synthetase alpha subunit
TNAP_RS04370	COG0751	glycine-tRNA ligase activity
TNAP_RS04375	COG1157	protein secretion by the type III secretion system
TNAP_RS04385	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
TNAP_RS04390	COG1766	The M ring may be actively involved in energy transduction
TNAP_RS04395	COG1122	ATPase activity
TNAP_RS04405	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
TNAP_RS04405	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
TNAP_RS04410	COG2515	1-aminocyclopropane-1-carboxylate deaminase
TNAP_RS04445	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
TNAP_RS04450	COG0772	Belongs to the SEDS family
TNAP_RS04460	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
TNAP_RS04465	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
TNAP_RS04470	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
TNAP_RS04480	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
TNAP_RS04505	COG4656	Part of a membrane complex involved in electron transport
TNAP_RS04510	COG4658	electron transport chain
TNAP_RS04520	COG4660	Part of a membrane complex involved in electron transport
TNAP_RS04530	COG2878	Part of a membrane complex involved in electron transport
TNAP_RS04535	COG0758	DNA mediated transformation
TNAP_RS04540	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
TNAP_RS04545	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
TNAP_RS04550	COG0792	nuclease activity
TNAP_RS04555	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
TNAP_RS04570	COG3481	metal-dependent phosphohydrolase, HD sub domain
TNAP_RS04575	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
TNAP_RS04580	COG1181	Belongs to the D-alanine--D-alanine ligase family
TNAP_RS04590	COG0306	phosphate transporter
TNAP_RS04595	COG0592	DNA-directed DNA polymerase activity
TNAP_RS04600	COG0445	tRNA wobble uridine modification
TNAP_RS04605	COG1187	pseudouridine synthase activity
TNAP_RS04610	COG0322	excinuclease ABC activity
TNAP_RS04615	COG0776	regulation of translation
TNAP_RS04620	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
TNAP_RS04625	COG1410	methionine synthase
TNAP_RS04625	COG0646	methionine synthase
TNAP_RS04635	COG0646	methionine synthase
TNAP_RS04635	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
TNAP_RS04645	COG0574	Belongs to the PEP-utilizing enzyme family
TNAP_RS04645	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
TNAP_RS04650	COG0191	fructose-bisphosphate aldolase activity
TNAP_RS04655	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
TNAP_RS04665	COG2160	L-arabinose isomerase activity
TNAP_RS04680	COG0395	ABC-type sugar transport system, permease component
TNAP_RS04705	COG1172	Belongs to the binding-protein-dependent transport system permease family
TNAP_RS04710	COG1129	ABC transporter
TNAP_RS04725	COG0371	Dehydrogenase
TNAP_RS04735	COG1132	(ABC) transporter
TNAP_RS04740	COG1132	(ABC) transporter
TNAP_RS04745	COG0205	6-phosphofructokinase activity
TNAP_RS04750	COG0372	Belongs to the citrate synthase family
TNAP_RS04755	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
TNAP_RS04760	COG0066	3-isopropylmalate dehydratase activity
TNAP_RS04765	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
TNAP_RS04770	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
TNAP_RS04775	COG1349	DNA-binding transcription factor activity
TNAP_RS04785	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
TNAP_RS04785	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
TNAP_RS04785	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
TNAP_RS04795	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
TNAP_RS04800	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
TNAP_RS04810	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
TNAP_RS04815	COG1609	Transcriptional regulator
TNAP_RS04820	COG1063	alcohol dehydrogenase
TNAP_RS04825	COG1653	transport
TNAP_RS04835	COG0395	ABC-type sugar transport system, permease component
TNAP_RS04845	COG1028	Short-chain dehydrogenase reductase Sdr
TNAP_RS04850	COG1063	alcohol dehydrogenase
TNAP_RS04875	COG1501	Belongs to the glycosyl hydrolase 31 family
TNAP_RS04880	COG0747	negative chemotaxis
TNAP_RS04900	COG0667	Aldo Keto reductase
TNAP_RS04920	COG2217	Heavy metal translocating P-type atpase
TNAP_RS04925	COG2226	methyltransferase
TNAP_RS04945	COG1028	Short-chain dehydrogenase reductase Sdr
TNAP_RS04950	COG1737	Transcriptional regulator
TNAP_RS04955	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
TNAP_RS04975	COG1574	metal-dependent hydrolase with the TIM-barrel fold
TNAP_RS04980	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
TNAP_RS04985	COG0284	orotidine-5'-phosphate decarboxylase activity
TNAP_RS04990	COG0167	dihydroorotate dehydrogenase activity
TNAP_RS04995	COG0543	2 iron, 2 sulfur cluster binding
TNAP_RS05000	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
TNAP_RS05005	COG1073	alpha beta
TNAP_RS05010	COG1032	radical SAM domain protein
TNAP_RS05030	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
TNAP_RS05040	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
TNAP_RS05045	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
TNAP_RS05055	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
TNAP_RS05055	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
TNAP_RS05060	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
TNAP_RS05070	COG1136	(ABC) transporter
TNAP_RS05070	COG0577	efflux transmembrane transporter activity
TNAP_RS05075	COG1136	(ABC) transporter
TNAP_RS05080	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
TNAP_RS05095	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
TNAP_RS05110	COG1597	lipid kinase activity
TNAP_RS05115	COG0438	transferase activity, transferring glycosyl groups
TNAP_RS05130	COG3706	GGDEF domain
TNAP_RS05135	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
TNAP_RS05135	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
TNAP_RS05140	COG0307	riboflavin synthase, alpha
TNAP_RS05145	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
TNAP_RS05145	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
TNAP_RS05160	COG0330	HflC and HflK could
TNAP_RS05165	COG0330	HflC and HflK could
TNAP_RS05170	COG1059	Responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine 7-oxoG) from DNA. Also nicks DNA at apurinic apyrimidinic sites (AP sites)
TNAP_RS05185	COG2059	Chromate
TNAP_RS05190	COG0525	valine-tRNA ligase activity
TNAP_RS05215	COG1353	crispr-associated protein
TNAP_RS05225	COG1337	RAMP superfamily
TNAP_RS05280	COG0640	Transcriptional regulator
TNAP_RS05295	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
TNAP_RS05300	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
TNAP_RS05305	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
TNAP_RS05315	COG0165	Argininosuccinate lyase
TNAP_RS05320	COG0137	argininosuccinate synthase activity
TNAP_RS05335	COG0195	Participates in both transcription termination and antitermination
TNAP_RS05340	COG0735	belongs to the Fur family
TNAP_RS05350	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
TNAP_RS05360	COG1461	Dihydroxyacetone kinase
TNAP_RS05375	COG1722	exodeoxyribonuclease VII activity
TNAP_RS05390	COG2759	Belongs to the formate--tetrahydrofolate ligase family
TNAP_RS05405	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
TNAP_RS05410	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
TNAP_RS05415	COG0556	nucleotide-excision repair
TNAP_RS05450	COG3426	butyrate kinase activity
TNAP_RS05455	COG0280	phosphate acetyltransferase
TNAP_RS05460	COG3426	butyrate kinase activity
TNAP_RS05470	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
TNAP_RS05475	COG0667	Aldo Keto reductase
TNAP_RS05480	COG0647	UMP catabolic process
TNAP_RS05485	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
TNAP_RS05490	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
TNAP_RS05505	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
TNAP_RS05510	COG0305	Participates in initiation and elongation during chromosome replication
TNAP_RS05520	COG0704	Plays a role in the regulation of phosphate uptake
TNAP_RS05525	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
TNAP_RS05535	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
TNAP_RS05540	COG2255	four-way junction helicase activity
TNAP_RS05560	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
TNAP_RS05565	COG1028	Short-chain dehydrogenase reductase Sdr
TNAP_RS05595	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
TNAP_RS05600	COG1162	GTPase activity
TNAP_RS05610	COG0820	rRNA (adenine-C2-)-methyltransferase activity
TNAP_RS05615	COG0812	UDP-N-acetylmuramate dehydrogenase activity
TNAP_RS05620	COG1739	Uncharacterized protein family UPF0029
TNAP_RS05635	COG1660	Displays ATPase and GTPase activities
TNAP_RS05640	COG0391	Required for morphogenesis under gluconeogenic growth conditions
TNAP_RS05650	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
TNAP_RS05655	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
TNAP_RS05660	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
TNAP_RS05670	COG1368	sulfuric ester hydrolase activity
TNAP_RS05690	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
TNAP_RS05695	COG0436	Aminotransferase
TNAP_RS05700	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
TNAP_RS05715	COG0301	tRNA thio-modification
TNAP_RS05735	COG2052	Domain of unknown function (DUF370)
TNAP_RS05740	COG0194	GDP metabolic process
TNAP_RS05745	COG1758	RNA polymerase activity
TNAP_RS05750	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
TNAP_RS05755	COG1376	ErfK ybiS ycfS ynhG family protein
TNAP_RS05760	COG1185	polyribonucleotide nucleotidyltransferase activity
TNAP_RS05770	COG1278	Cold shock
TNAP_RS05775	COG3437	response regulator, receiver
TNAP_RS05820	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
TNAP_RS05840	COG1396	sequence-specific DNA binding
TNAP_RS05860	COG2115	Belongs to the xylose isomerase family
TNAP_RS05865	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
TNAP_RS05875	COG2813	Specifically methylates the guanine in position
TNAP_RS05880	COG1122	ATPase activity
TNAP_RS05905	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
TNAP_RS05910	COG0268	Binds directly to 16S ribosomal RNA
TNAP_RS05920	COG0745	RESPONSE REGULATOR receiver
TNAP_RS05925	COG5002	protein histidine kinase activity
TNAP_RS05940	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
TNAP_RS05955	COG1713	HD superfamily hydrolase involved in NAD metabolism
TNAP_RS05965	COG1728	Protein conserved in bacteria
TNAP_RS05970	COG0157	Belongs to the NadC ModD family
TNAP_RS05990	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
TNAP_RS05990	COG0540	Belongs to the ATCase OTCase family
TNAP_RS05995	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
TNAP_RS06005	COG0543	2 iron, 2 sulfur cluster binding
TNAP_RS06010	COG4555	ABC transporter
TNAP_RS06020	COG0419	ATPase involved in DNA repair
TNAP_RS06025	COG0420	3'-5' exonuclease activity
TNAP_RS06035	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
TNAP_RS06040	COG0802	atpase or kinase
TNAP_RS06055	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
TNAP_RS06060	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
TNAP_RS06080	COG3250	beta-galactosidase activity
TNAP_RS06085	COG0481	GTPase activity
TNAP_RS06095	COG0584	glycerophosphoryl diester phosphodiesterase
TNAP_RS06105	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
TNAP_RS06105	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
TNAP_RS06110	COG1406	Chemotaxis phosphatase CheX
TNAP_RS06125	COG0356	it plays a direct role in the translocation of protons across the membrane
TNAP_RS06130	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
TNAP_RS06135	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
TNAP_RS06140	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
TNAP_RS06145	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
TNAP_RS06150	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
TNAP_RS06155	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
TNAP_RS06160	COG0355	proton-transporting ATP synthase activity, rotational mechanism
TNAP_RS06165	COG1307	EDD domain protein, DegV family
TNAP_RS06170	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
TNAP_RS06175	COG1530	ribonuclease E activity
TNAP_RS06180	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
TNAP_RS06185	COG0528	UMP kinase activity
TNAP_RS06195	COG1827	regulation of RNA biosynthetic process
TNAP_RS06200	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TNAP_RS06215	COG1595	DNA-templated transcription, initiation
TNAP_RS06225	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
TNAP_RS06230	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
TNAP_RS06240	COG0489	protein tyrosine kinase activity
TNAP_RS06245	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
TNAP_RS06250	COG0291	Belongs to the bacterial ribosomal protein bL35 family
TNAP_RS06255	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
TNAP_RS06305	COG2379	hydroxypyruvate reductase
TNAP_RS06310	COG1040	competence protein
TNAP_RS06340	COG0653	protein targeting
TNAP_RS06350	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
TNAP_RS06360	COG0101	tRNA pseudouridine synthase activity
TNAP_RS06370	COG0681	Belongs to the peptidase S26 family
TNAP_RS06375	COG0335	large ribosomal subunit rRNA binding
TNAP_RS06380	COG4752	Belongs to the RNA methyltransferase TrmD family
TNAP_RS06385	COG0336	Belongs to the RNA methyltransferase TrmD family
TNAP_RS06390	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
TNAP_RS06395	COG1837	Belongs to the UPF0109 family
TNAP_RS06400	COG0228	four-way junction DNA binding
TNAP_RS06405	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
TNAP_RS06410	COG1254	Belongs to the acylphosphatase family
TNAP_RS06435	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
TNAP_RS06445	COG2003	Belongs to the UPF0758 family
TNAP_RS06450	COG0424	maF-like protein
TNAP_RS06465	COG1477	protein flavinylation
TNAP_RS06475	COG2078	PFAM AMMECR1 domain protein
TNAP_RS06480	COG3872	metal-dependent enzyme
TNAP_RS06485	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
TNAP_RS06490	COG1086	Polysaccharide biosynthesis protein
TNAP_RS06495	COG1078	dGTPase activity
TNAP_RS06500	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
TNAP_RS06500	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
TNAP_RS06520	COG4786	Flagellar basal body rod
TNAP_RS06535	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
TNAP_RS06540	COG1706	bacterial-type flagellum-dependent cell motility
TNAP_RS06550	COG1032	radical SAM domain protein
TNAP_RS06575	COG0644	oxidoreductase
TNAP_RS06580	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
TNAP_RS06585	COG2086	electron transfer activity
TNAP_RS06595	COG1575	Belongs to the MenA family. Type 1 subfamily
TNAP_RS06600	COG1959	2 iron, 2 sulfur cluster binding
TNAP_RS06630	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
TNAP_RS06640	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
TNAP_RS06660	COG0019	diaminopimelate decarboxylase activity
TNAP_RS06665	COG1473	amidohydrolase
TNAP_RS06680	COG1323	Belongs to the UPF0348 family
TNAP_RS06685	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
TNAP_RS06685	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
TNAP_RS06690	COG2738	Putative neutral zinc metallopeptidase
TNAP_RS06700	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
TNAP_RS06705	COG1480	7TM receptor with intracellular HD hydrolase
TNAP_RS06710	COG1702	phosphate starvation-inducible protein PhoH
TNAP_RS06720	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
TNAP_RS06725	COG0049	tRNA binding
TNAP_RS06730	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
TNAP_RS06735	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
TNAP_RS06740	COG0051	transcription antitermination factor activity, RNA binding
TNAP_RS06745	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
TNAP_RS06750	COG0088	Forms part of the polypeptide exit tunnel
TNAP_RS06755	COG0089	rRNA binding
TNAP_RS06760	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
TNAP_RS06765	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
TNAP_RS06780	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
TNAP_RS06785	COG0255	Belongs to the universal ribosomal protein uL29 family
TNAP_RS06790	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
TNAP_RS06795	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
TNAP_RS06800	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
TNAP_RS06810	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
TNAP_RS06815	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
TNAP_RS06820	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
TNAP_RS06825	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
TNAP_RS06830	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
TNAP_RS06835	COG1841	ribosomal large subunit assembly
TNAP_RS06840	COG0200	Binds to the 23S rRNA
TNAP_RS06845	COG0201	protein transport
TNAP_RS06850	COG0563	adenylate kinase activity
TNAP_RS06860	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
TNAP_RS06865	COG0257	Belongs to the bacterial ribosomal protein bL36 family
TNAP_RS06870	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
TNAP_RS06875	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
TNAP_RS06880	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
TNAP_RS06885	COG0202	RNA polymerase activity
TNAP_RS06890	COG0203	ribosomal protein L17
TNAP_RS06895	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
TNAP_RS06905	COG1307	EDD domain protein, DegV family
TNAP_RS06915	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
TNAP_RS06920	COG0218	Necessary for normal cell division and for the maintenance of normal septation
TNAP_RS06925	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
TNAP_RS06930	COG2313	pseudouridylate synthase activity
TNAP_RS06935	COG0230	Belongs to the bacterial ribosomal protein bL34 family
TNAP_RS06940	COG0594	ribonuclease P activity
TNAP_RS06945	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
TNAP_RS06950	COG0706	membrane insertase activity
TNAP_RS06975	COG0211	Belongs to the bacterial ribosomal protein bL27 family
TNAP_RS06980	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
TNAP_RS06985	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
TNAP_RS06995	COG0358	DNA primase activity
TNAP_RS07000	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
TNAP_RS07005	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
TNAP_RS07020	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
TNAP_RS07045	COG1366	Belongs to the anti-sigma-factor antagonist family
TNAP_RS07055	COG2050	protein possibly involved in aromatic compounds catabolism
TNAP_RS07055	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
TNAP_RS07065	COG1543	Belongs to the glycosyl hydrolase 57 family
TNAP_RS07100	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
TNAP_RS07110	COG0840	transmembrane signaling receptor activity
TNAP_RS07115	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
TNAP_RS07130	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
TNAP_RS07145	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
TNAP_RS07155	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
TNAP_RS07160	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
TNAP_RS07160	COG1213	nucleotidyl transferase
TNAP_RS07170	COG0719	Fe-S assembly protein
TNAP_RS07180	COG0483	inositol monophosphate 1-phosphatase activity
TNAP_RS07185	COG1621	beta-fructofuranosidase activity
TNAP_RS07205	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
TNAP_RS07210	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
TNAP_RS07215	COG0233	cytoplasmic translational termination
TNAP_RS07220	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
TNAP_RS07225	COG0575	Belongs to the CDS family
TNAP_RS07240	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
TNAP_RS07245	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
TNAP_RS07255	COG0542	response to heat
TNAP_RS07275	COG2264	protein methyltransferase activity
TNAP_RS07280	COG0742	ribosomal rna small subunit methyltransferase
TNAP_RS07285	COG0237	dephospho-CoA kinase activity
TNAP_RS07295	COG0166	Belongs to the GPI family
TNAP_RS07300	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
TNAP_RS07325	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
TNAP_RS07330	COG1177	transmembrane transport
TNAP_RS07335	COG1176	ABC-type spermidine putrescine transport system, permease component I
TNAP_RS07340	COG3842	ATPase activity
TNAP_RS07345	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
TNAP_RS07355	COG0406	alpha-ribazole phosphatase activity
TNAP_RS07365	COG0822	iron-sulfur transferase activity
TNAP_RS07370	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
TNAP_RS07380	COG0719	Fe-S assembly protein
TNAP_RS07385	COG0396	ATPase activity
TNAP_RS07400	COG1677	Flagellar hook-basal body complex protein FliE
TNAP_RS07410	COG1815	bacterial-type flagellum-dependent cell motility
TNAP_RS07415	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
TNAP_RS07425	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
TNAP_RS07430	COG0745	RESPONSE REGULATOR receiver
TNAP_RS07435	COG3852	Histidine kinase
TNAP_RS07460	COG0517	IMP dehydrogenase activity
TNAP_RS07460	COG0516	GMP reductase activity
TNAP_RS07475	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
TNAP_RS07480	COG2267	carboxylic ester hydrolase activity
TNAP_RS07485	COG0628	permease
TNAP_RS07495	COG0516	GMP reductase activity
TNAP_RS07495	COG0517	IMP dehydrogenase activity
TNAP_RS07500	COG0612	Peptidase, M16
TNAP_RS07510	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
TNAP_RS07590	COG1132	(ABC) transporter
TNAP_RS07595	COG4555	ABC transporter
TNAP_RS07610	COG0641	radical SAM
TNAP_RS07640	COG1598	PFAM Uncharacterised protein family UPF0150
TNAP_RS07650	COG1132	(ABC) transporter
TNAP_RS07655	COG1132	(ABC) transporter
TNAP_RS07670	COG1598	PFAM Uncharacterised protein family UPF0150
TNAP_RS07680	COG1598	PFAM Uncharacterised protein family UPF0150
TNAP_RS07710	COG4555	ABC transporter
TNAP_RS07730	COG0667	Aldo Keto reductase
TNAP_RS07745	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TNAP_RS07760	COG0662	Cupin 2, conserved barrel domain protein
TNAP_RS07765	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
TNAP_RS07770	COG1486	melibiose metabolic process
TNAP_RS07795	COG3842	ATPase activity
TNAP_RS07815	COG0154	amidase activity
TNAP_RS07820	COG2165	general secretion pathway protein
TNAP_RS07825	COG0626	cystathionine gamma-synthase activity
TNAP_RS07830	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
TNAP_RS07855	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
TNAP_RS07870	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
TNAP_RS07875	COG0704	Plays a role in the regulation of phosphate uptake
TNAP_RS07880	COG0745	RESPONSE REGULATOR receiver
TNAP_RS07895	COG1132	(ABC) transporter
TNAP_RS07900	COG0436	Aminotransferase
TNAP_RS07905	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
TNAP_RS07910	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
TNAP_RS07910	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
TNAP_RS07925	COG0151	Belongs to the GarS family
TNAP_RS07930	COG0138	bifunctional purine biosynthesis protein purh
TNAP_RS07935	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
TNAP_RS07940	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
TNAP_RS07945	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
TNAP_RS07950	COG0047	phosphoribosylformylglycinamidine synthase activity
TNAP_RS07955	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
TNAP_RS07960	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
TNAP_RS07975	COG0012	GTP binding
TNAP_RS07985	COG0210	DNA helicase
TNAP_RS08010	COG3842	ATPase activity
TNAP_RS08015	COG0383	alpha-mannosidase activity
TNAP_RS08020	COG0438	transferase activity, transferring glycosyl groups
TNAP_RS08025	COG0463	Glycosyl transferase, family 2
TNAP_RS08040	COG0747	negative chemotaxis
TNAP_RS08045	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
TNAP_RS08050	COG1940	carbohydrate kinase activity
TNAP_RS08055	COG4166	transmembrane transport
TNAP_RS08060	COG0601	transmembrane transport
TNAP_RS08065	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TNAP_RS08070	COG0444	Belongs to the ABC transporter superfamily
TNAP_RS08075	COG4608	Belongs to the ABC transporter superfamily
TNAP_RS08080	COG1609	Transcriptional regulator
TNAP_RS08095	COG3250	beta-galactosidase activity
TNAP_RS08100	COG3345	alpha-galactosidase
TNAP_RS08105	COG1085	galactose-1-phosphate uridylyltransferase
TNAP_RS08110	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
TNAP_RS08120	COG2199	diguanylate cyclase activity
TNAP_RS08135	COG0628	permease
TNAP_RS08145	COG1803	Methylglyoxal synthase
TNAP_RS08155	COG0667	Aldo Keto reductase
TNAP_RS08160	COG1196	nuclear chromosome segregation
TNAP_RS08165	COG0494	nUDIX hydrolase
TNAP_RS08175	COG1516	flagellar protein fliS
TNAP_RS08180	COG0456	acetyltransferase
TNAP_RS08185	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
TNAP_RS08190	COG1151	hydroxylamine reductase activity
TNAP_RS08205	COG1028	Short-chain dehydrogenase reductase Sdr
TNAP_RS08210	COG0058	SHG alpha-glucan phosphorylase activity
TNAP_RS08220	COG0635	Involved in the biosynthesis of porphyrin-containing compound
TNAP_RS08225	COG1013	pyruvate-flavodoxin oxidoreductase activity
TNAP_RS08235	COG2199	diguanylate cyclase activity
TNAP_RS08240	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
TNAP_RS08245	COG2239	Acts as a magnesium transporter
TNAP_RS08260	COG0010	Belongs to the arginase family
TNAP_RS08275	COG1983	PspC domain protein
TNAP_RS08280	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
TNAP_RS08285	COG0363	glucosamine-6-phosphate deaminase activity
TNAP_RS08290	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TNAP_RS08295	COG0444	Belongs to the ABC transporter superfamily
TNAP_RS08300	COG4608	Belongs to the ABC transporter superfamily
TNAP_RS08305	COG0747	negative chemotaxis
TNAP_RS08310	COG0601	transmembrane transport
TNAP_RS08325	COG0785	Cytochrome C biogenesis protein
TNAP_RS08330	COG0516	GMP reductase activity
TNAP_RS08330	COG0517	IMP dehydrogenase activity
TNAP_RS08370	COG0714	Associated with various cellular activities
TNAP_RS08375	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
TNAP_RS08380	COG0280	phosphate acetyltransferase
TNAP_RS08385	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
TNAP_RS08415	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
TNAP_RS08425	COG1175	transmembrane transport
TNAP_RS08430	COG1653	transport
TNAP_RS08505	COG0651	ATP synthesis coupled electron transport
TNAP_RS08525	COG0622	Phosphoesterase
TNAP_RS08535	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
TNAP_RS08545	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
TNAP_RS08550	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
TNAP_RS08555	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
TNAP_RS08560	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
TNAP_RS08585	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
TNAP_RS08595	COG0569	domain protein
TNAP_RS08610	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TNAP_RS08610	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TNAP_RS08615	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
TNAP_RS08620	COG1371	PFAM Archease protein family (DUF101 UPF0211)
TNAP_RS08625	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
TNAP_RS08635	COG0698	ribose 5-phosphate isomerase
TNAP_RS08640	COG2264	protein methyltransferase activity
TNAP_RS08650	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
TNAP_RS08670	COG1070	Carbohydrate kinase
TNAP_RS08680	COG4952	isomerase
TNAP_RS08690	COG1349	DNA-binding transcription factor activity
TNAP_RS08695	COG1129	ABC transporter
TNAP_RS08705	COG1172	Belongs to the binding-protein-dependent transport system permease family
TNAP_RS08715	COG3250	beta-galactosidase activity
TNAP_RS08730	COG2359	stage V sporulation protein S
TNAP_RS08740	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
TNAP_RS08745	COG1324	tolerance protein
TNAP_RS08755	COG1137	ATPase activity
TNAP_RS08765	COG1555	photosystem II stabilization
TNAP_RS08765	COG1596	polysaccharide export
TNAP_RS08805	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
TNAP_RS08810	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
TNAP_RS08815	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
TNAP_RS08820	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
TNAP_RS08825	COG0131	Imidazoleglycerol-phosphate dehydratase
TNAP_RS08830	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
TNAP_RS08835	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
TNAP_RS08840	COG0107	imidazoleglycerol-phosphate synthase activity
TNAP_RS08845	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
TNAP_RS08845	COG0140	phosphoribosyl-ATP diphosphatase activity
TNAP_RS08850	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
TNAP_RS08880	COG1131	(ABC) transporter
TNAP_RS08900	COG2814	Major facilitator Superfamily
TNAP_RS08925	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
TNAP_RS08970	COG0656	L-ascorbic acid biosynthetic process
TNAP_RS08975	COG0667	Aldo Keto reductase
TNAP_RS08985	COG2202	Pas domain
TNAP_RS08985	COG2200	EAL domain
TNAP_RS08985	COG2199	diguanylate cyclase activity
TNAP_RS09030	COG0827	DNA restriction-modification system
TNAP_RS09040	COG3234	Protein of unknown function (DUF1175)
TNAP_RS09050	COG2373	Large extracellular alpha-helical protein
TNAP_RS09055	COG0425	Belongs to the sulfur carrier protein TusA family
TNAP_RS09080	COG0425	Belongs to the sulfur carrier protein TusA family
TNAP_RS09090	COG0840	transmembrane signaling receptor activity
TNAP_RS09095	COG3706	GGDEF domain
TNAP_RS09110	COG4974	Belongs to the 'phage' integrase family
TNAP_RS09115	COG1606	tRNA processing
TNAP_RS09120	COG1691	(AIR) carboxylase
TNAP_RS09135	COG1193	negative regulation of DNA recombination
TNAP_RS09140	COG1193	negative regulation of DNA recombination
TNAP_RS09145	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
TNAP_RS09150	COG1704	LemA family
TNAP_RS09155	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
TNAP_RS09165	COG1869	D-ribose catabolic process
TNAP_RS09170	COG1129	ABC transporter
TNAP_RS09175	COG1172	Belongs to the binding-protein-dependent transport system permease family
TNAP_RS09180	COG1879	ABC-type sugar transport system periplasmic component
TNAP_RS09210	COG0174	glutamine synthetase
TNAP_RS09230	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
TNAP_RS09245	COG0402	S-adenosylhomocysteine deaminase activity
TNAP_RS09250	COG0517	IMP dehydrogenase activity
TNAP_RS09250	COG0516	GMP reductase activity
TNAP_RS09255	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
TNAP_RS09275	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
TNAP_RS09280	COG3864	Putative metallopeptidase domain
TNAP_RS09290	COG1141	Ferredoxin