locus-tag	class	description
CTN_RS00005	COG1476	TRANSCRIPTIONal
CTN_RS00010	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
CTN_RS00015	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
CTN_RS00020	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CTN_RS00030	COG0561	phosphatase activity
CTN_RS00050	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
CTN_RS00060	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
CTN_RS00080	COG1011	Hydrolase
CTN_RS00115	COG3951	Flagellar rod assembly protein muramidase FlgJ
CTN_RS00115	COG1705	Flagellar rod assembly protein muramidase FlgJ
CTN_RS00120	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CTN_RS00125	COG0463	Glycosyl transferase, family 2
CTN_RS00175	COG1091	dTDP-4-dehydrorhamnose reductase activity
CTN_RS00190	COG0438	transferase activity, transferring glycosyl groups
CTN_RS00190	COG0297	glycogen (starch) synthase activity
CTN_RS00225	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CTN_RS00240	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
CTN_RS00255	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CTN_RS00270	COG0629	single-stranded DNA binding
CTN_RS00275	COG0360	Binds together with S18 to 16S ribosomal RNA
CTN_RS00300	COG0395	ABC-type sugar transport system, permease component
CTN_RS00305	COG1175	transmembrane transport
CTN_RS00315	COG2252	PERMEase
CTN_RS00320	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CTN_RS00325	COG0765	amino acid transport
CTN_RS00330	COG1126	abc transporter atp-binding protein
CTN_RS00350	COG1077	Cell shape determining protein MreB Mrl
CTN_RS00355	COG0517	IMP dehydrogenase activity
CTN_RS00355	COG1227	inorganic diphosphatase activity
CTN_RS00360	COG0697	spore germination
CTN_RS00390	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CTN_RS00395	COG0037	tRNA processing
CTN_RS00405	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CTN_RS00410	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CTN_RS00415	COG2176	DNA-directed DNA polymerase activity
CTN_RS00420	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
CTN_RS00425	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
CTN_RS00430	COG0815	Transfers the fatty acyl group on membrane lipoproteins
CTN_RS00435	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CTN_RS00440	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CTN_RS00445	COG0552	protein localization to endoplasmic reticulum
CTN_RS00455	COG3584	3D domain protein
CTN_RS00460	COG1959	2 iron, 2 sulfur cluster binding
CTN_RS00470	COG1489	DNA binding
CTN_RS00495	COG1181	Belongs to the D-alanine--D-alanine ligase family
CTN_RS00500	COG0598	Magnesium transport protein CorA
CTN_RS00515	COG0505	Belongs to the CarA family
CTN_RS00520	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CTN_RS00525	COG0473	3-isopropylmalate dehydrogenase activity
CTN_RS00530	COG0066	3-isopropylmalate dehydratase activity
CTN_RS00535	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
CTN_RS00540	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CTN_RS00545	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CTN_RS00550	COG0129	dihydroxy-acid dehydratase activity
CTN_RS00555	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
CTN_RS00560	COG0440	acetolactate synthase activity
CTN_RS00565	COG0028	Belongs to the TPP enzyme family
CTN_RS00570	COG0527	aspartate kinase activity
CTN_RS00575	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
CTN_RS00580	COG0083	homoserine kinase activity
CTN_RS00585	COG1131	(ABC) transporter
CTN_RS00600	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
CTN_RS00600	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
CTN_RS00610	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
CTN_RS00620	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
CTN_RS00625	COG1230	cation diffusion facilitator family transporter
CTN_RS00630	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CTN_RS00645	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CTN_RS00650	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CTN_RS00655	COG0601	transmembrane transport
CTN_RS00660	COG0747	negative chemotaxis
CTN_RS00665	COG4608	Belongs to the ABC transporter superfamily
CTN_RS00675	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CTN_RS00680	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CTN_RS00690	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
CTN_RS00710	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
CTN_RS00715	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
CTN_RS00720	COG0482	sulfurtransferase activity
CTN_RS00745	COG1242	4 iron, 4 sulfur cluster binding
CTN_RS00750	COG0442	prolyl-tRNA aminoacylation
CTN_RS00755	COG0606	chelatase, subunit chli
CTN_RS00765	COG1573	uracil-dna glycosylase
CTN_RS00780	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
CTN_RS00780	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
CTN_RS00795	COG0601	transmembrane transport
CTN_RS00800	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CTN_RS00805	COG0444	Belongs to the ABC transporter superfamily
CTN_RS00810	COG4608	Belongs to the ABC transporter superfamily
CTN_RS00820	COG0444	Belongs to the ABC transporter superfamily
CTN_RS00830	COG2176	DNA-directed DNA polymerase activity
CTN_RS00835	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
CTN_RS00840	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
CTN_RS00845	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
CTN_RS00850	COG0180	Tryptophanyl-tRNA synthetase
CTN_RS00860	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
CTN_RS00865	COG1595	DNA-templated transcription, initiation
CTN_RS00870	COG2890	protein-(glutamine-N5) methyltransferase activity
CTN_RS00875	COG2151	metal-sulfur cluster biosynthetic enzyme
CTN_RS00885	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CTN_RS00890	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CTN_RS00925	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CTN_RS00930	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CTN_RS00935	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
CTN_RS00940	COG1196	nuclear chromosome segregation
CTN_RS00955	COG3433	isochorismatase activity
CTN_RS00955	COG1535	isochorismatase
CTN_RS00965	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
CTN_RS00970	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
CTN_RS00990	COG0745	RESPONSE REGULATOR receiver
CTN_RS01010	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
CTN_RS01015	COG0564	pseudouridine synthase activity
CTN_RS01020	COG0587	DNA-directed DNA polymerase activity
CTN_RS01030	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
CTN_RS01040	COG0222	ribosome binding
CTN_RS01045	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
CTN_RS01050	COG0081	regulation of translation
CTN_RS01055	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
CTN_RS01060	COG0250	Participates in transcription elongation, termination and antitermination
CTN_RS01065	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CTN_RS01095	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
CTN_RS01100	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CTN_RS01105	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
CTN_RS01110	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
CTN_RS01115	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
CTN_RS01120	COG1027	Aspartate ammonia-lyase
CTN_RS01125	COG1070	Carbohydrate kinase
CTN_RS01135	COG1028	Short-chain dehydrogenase reductase Sdr
CTN_RS01145	COG1802	Transcriptional regulator
CTN_RS01150	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
CTN_RS01165	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CTN_RS01175	COG1172	Belongs to the binding-protein-dependent transport system permease family
CTN_RS01185	COG1234	tRNA 3'-trailer cleavage
CTN_RS01190	COG3842	ATPase activity
CTN_RS01195	COG4149	molybdate abc transporter
CTN_RS01200	COG1176	ABC-type spermidine putrescine transport system, permease component I
CTN_RS01215	COG0371	Dehydrogenase
CTN_RS01225	COG3842	ATPase activity
CTN_RS01230	COG3833	ABC-type maltose transport systems, permease component
CTN_RS01235	COG1175	transmembrane transport
CTN_RS01245	COG1082	Xylose isomerase domain protein TIM barrel
CTN_RS01255	COG0673	inositol 2-dehydrogenase activity
CTN_RS01260	COG1402	creatininase
CTN_RS01265	COG1063	alcohol dehydrogenase
CTN_RS01280	COG0739	heme binding
CTN_RS01285	COG2201	protein-glutamate methylesterase activity
CTN_RS01300	COG1013	pyruvate-flavodoxin oxidoreductase activity
CTN_RS01310	COG0347	Belongs to the P(II) protein family
CTN_RS01315	COG0004	ammonium transporteR
CTN_RS01325	COG3850	Histidine kinase
CTN_RS01325	COG5002	protein histidine kinase activity
CTN_RS01340	COG0067	glutamate synthase
CTN_RS01345	COG0069	glutamate synthase activity
CTN_RS01345	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
CTN_RS01350	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
CTN_RS01350	COG0493	'glutamate synthase
CTN_RS01355	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CTN_RS01370	COG0438	transferase activity, transferring glycosyl groups
CTN_RS01380	COG0577	efflux transmembrane transporter activity
CTN_RS01380	COG1136	(ABC) transporter
CTN_RS01385	COG1136	(ABC) transporter
CTN_RS01390	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CTN_RS01415	COG1597	lipid kinase activity
CTN_RS01420	COG0438	transferase activity, transferring glycosyl groups
CTN_RS01425	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
CTN_RS01430	COG3956	TIGRFAM MazG family protein
CTN_RS01440	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
CTN_RS01460	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
CTN_RS01480	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
CTN_RS01485	COG1438	arginine binding
CTN_RS01495	COG0443	Heat shock 70 kDa protein
CTN_RS01500	COG0071	Belongs to the small heat shock protein (HSP20) family
CTN_RS01505	COG4869	propanediol catabolic process
CTN_RS01510	COG0730	response to heat
CTN_RS01530	COG0778	Nitroreductase
CTN_RS01535	COG1328	CTP reductase activity
CTN_RS01545	COG0778	Nitroreductase
CTN_RS01550	COG1194	a g-specific adenine glycosylase
CTN_RS01565	COG0446	pyridine nucleotide-disulphide oxidoreductase
CTN_RS01570	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
CTN_RS01580	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
CTN_RS01585	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
CTN_RS01585	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
CTN_RS01595	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CTN_RS01600	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
CTN_RS01610	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
CTN_RS01630	COG1032	radical SAM domain protein
CTN_RS01635	COG1073	alpha beta
CTN_RS01640	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CTN_RS01645	COG0543	2 iron, 2 sulfur cluster binding
CTN_RS01650	COG0167	dihydroorotate dehydrogenase activity
CTN_RS01655	COG0284	orotidine-5'-phosphate decarboxylase activity
CTN_RS01660	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
CTN_RS01665	COG1574	metal-dependent hydrolase with the TIM-barrel fold
CTN_RS01685	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CTN_RS01690	COG1737	Transcriptional regulator
CTN_RS01695	COG1028	Short-chain dehydrogenase reductase Sdr
CTN_RS01700	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
CTN_RS01710	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CTN_RS01730	COG2226	methyltransferase
CTN_RS01735	COG2217	Heavy metal translocating P-type atpase
CTN_RS01765	COG1175	transmembrane transport
CTN_RS01790	COG1172	Belongs to the binding-protein-dependent transport system permease family
CTN_RS01795	COG1172	Belongs to the binding-protein-dependent transport system permease family
CTN_RS01800	COG1879	ABC-type sugar transport system periplasmic component
CTN_RS01805	COG1028	Short-chain dehydrogenase reductase Sdr
CTN_RS01810	COG1129	ABC transporter
CTN_RS01815	COG1172	Belongs to the binding-protein-dependent transport system permease family
CTN_RS01820	COG0673	inositol 2-dehydrogenase activity
CTN_RS01830	COG1070	Carbohydrate kinase
CTN_RS01835	COG2188	Transcriptional regulator
CTN_RS01850	COG0667	Aldo Keto reductase
CTN_RS01875	COG1501	Belongs to the glycosyl hydrolase 31 family
CTN_RS01895	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
CTN_RS01900	COG1063	alcohol dehydrogenase
CTN_RS01905	COG1028	Short-chain dehydrogenase reductase Sdr
CTN_RS01910	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CTN_RS01915	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
CTN_RS01920	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
CTN_RS01930	COG0066	3-isopropylmalate dehydratase activity
CTN_RS01935	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
CTN_RS01940	COG0372	Belongs to the citrate synthase family
CTN_RS01945	COG0205	6-phosphofructokinase activity
CTN_RS01950	COG1132	(ABC) transporter
CTN_RS01955	COG1132	(ABC) transporter
CTN_RS01965	COG0371	Dehydrogenase
CTN_RS01970	COG1070	Carbohydrate kinase
CTN_RS02000	COG1175	transmembrane transport
CTN_RS02010	COG2160	L-arabinose isomerase activity
CTN_RS02020	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
CTN_RS02025	COG0191	fructose-bisphosphate aldolase activity
CTN_RS02030	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CTN_RS02030	COG0574	Belongs to the PEP-utilizing enzyme family
CTN_RS02040	COG0646	methionine synthase
CTN_RS02040	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
CTN_RS02050	COG0646	methionine synthase
CTN_RS02050	COG1410	methionine synthase
CTN_RS02060	COG0776	regulation of translation
CTN_RS02070	COG1187	pseudouridine synthase activity
CTN_RS02080	COG0592	DNA-directed DNA polymerase activity
CTN_RS02085	COG0306	phosphate transporter
CTN_RS02095	COG1181	Belongs to the D-alanine--D-alanine ligase family
CTN_RS02100	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CTN_RS02105	COG3481	metal-dependent phosphohydrolase, HD sub domain
CTN_RS02120	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
CTN_RS02125	COG0792	nuclease activity
CTN_RS02130	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CTN_RS02135	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
CTN_RS02140	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CTN_RS02140	COG0758	DNA mediated transformation
CTN_RS02145	COG2878	Part of a membrane complex involved in electron transport
CTN_RS02150	COG4657	Part of a membrane complex involved in electron transport
CTN_RS02155	COG4660	Part of a membrane complex involved in electron transport
CTN_RS02160	COG4659	FMN binding
CTN_RS02165	COG4658	electron transport chain
CTN_RS02170	COG4656	Part of a membrane complex involved in electron transport
CTN_RS02175	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
CTN_RS02190	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
CTN_RS02195	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
CTN_RS02205	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CTN_RS02210	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
CTN_RS02215	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CTN_RS02220	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
CTN_RS02225	COG0772	Belongs to the SEDS family
CTN_RS02230	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CTN_RS02235	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CTN_RS02265	COG2515	1-aminocyclopropane-1-carboxylate deaminase
CTN_RS02270	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
CTN_RS02270	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
CTN_RS02280	COG1122	ATPase activity
CTN_RS02285	COG1766	The M ring may be actively involved in energy transduction
CTN_RS02290	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CTN_RS02300	COG1157	protein secretion by the type III secretion system
CTN_RS02305	COG0751	glycine-tRNA ligase activity
CTN_RS02310	COG0752	glycyl-tRNA synthetase alpha subunit
CTN_RS02315	COG0251	oxidation-reduction process
CTN_RS02320	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CTN_RS02330	COG0509	glycine decarboxylation via glycine cleavage system
CTN_RS02335	COG0404	The glycine cleavage system catalyzes the degradation of glycine
CTN_RS02345	COG0205	6-phosphofructokinase activity
CTN_RS02350	COG0469	pyruvate kinase activity
CTN_RS02355	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
CTN_RS02360	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
CTN_RS02365	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
CTN_RS02375	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CTN_RS02390	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
CTN_RS02395	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
CTN_RS02400	COG0542	response to heat
CTN_RS02405	COG0037	tRNA processing
CTN_RS02415	COG0248	Ppx GppA phosphatase
CTN_RS02430	COG1136	(ABC) transporter
CTN_RS02435	COG0390	transport system, permease component
CTN_RS02470	COG2359	stage V sporulation protein S
CTN_RS02480	COG1120	ATPase activity
CTN_RS02485	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CTN_RS02490	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CTN_RS02495	COG1720	tRNA m6t6A37 methyltransferase activity
CTN_RS02515	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CTN_RS02525	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CTN_RS02570	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
CTN_RS02575	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CTN_RS02585	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CTN_RS02590	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
CTN_RS02595	COG1110	DNA topoisomerase II activity
CTN_RS02600	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
CTN_RS02605	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
CTN_RS02615	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
CTN_RS02620	COG0495	leucyl-tRNA aminoacylation
CTN_RS02625	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
CTN_RS02630	COG0285	dihydrofolate synthase activity
CTN_RS02635	COG0632	four-way junction helicase activity
CTN_RS02665	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
CTN_RS02670	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
CTN_RS02685	COG1785	Belongs to the alkaline phosphatase family
CTN_RS02710	COG0333	Belongs to the bacterial ribosomal protein bL32 family
CTN_RS02715	COG0416	fatty acid biosynthetic process
CTN_RS02720	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CTN_RS02725	COG0799	negative regulation of ribosome biogenesis
CTN_RS02730	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
CTN_RS02735	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
CTN_RS02760	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
CTN_RS02765	COG0512	Glutamine amidotransferase of anthranilate synthase
CTN_RS02765	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CTN_RS02770	COG0134	indole-3-glycerol-phosphate synthase activity
CTN_RS02775	COG0135	phosphoribosylanthranilate isomerase activity
CTN_RS02780	COG0133	tryptophan synthase activity
CTN_RS02785	COG0159	tryptophan synthase activity
CTN_RS02790	COG0820	rRNA (adenine-C2-)-methyltransferase activity
CTN_RS02800	COG0492	ferredoxin-NADP+ reductase activity
CTN_RS02805	COG1335	isochorismatase
CTN_RS02810	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CTN_RS02840	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CTN_RS02845	COG1121	(ABC) transporter
CTN_RS02850	COG0803	Belongs to the bacterial solute-binding protein 9 family
CTN_RS02860	COG1509	lysine 2,3-aminomutase activity
CTN_RS02865	COG0778	Nitroreductase
CTN_RS02885	COG1070	Carbohydrate kinase
CTN_RS02890	COG1129	ABC transporter
CTN_RS02905	COG1172	Belongs to the binding-protein-dependent transport system permease family
CTN_RS02915	COG1940	carbohydrate kinase activity
CTN_RS02925	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CTN_RS02940	COG1079	Belongs to the binding-protein-dependent transport system permease family
CTN_RS02945	COG4603	Belongs to the binding-protein-dependent transport system permease family
CTN_RS02950	COG3845	ABC transporter
CTN_RS02955	COG1744	ABC transporter substrate-binding protein PnrA-like
CTN_RS02965	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CTN_RS02975	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
CTN_RS02980	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
CTN_RS02985	COG3116	cell division
CTN_RS02985	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CTN_RS02995	COG1459	type II secretion system
CTN_RS03030	COG1355	regulation of microtubule-based process
CTN_RS03035	COG0728	peptidoglycan biosynthetic process
CTN_RS03050	COG1256	bacterial-type flagellum assembly
CTN_RS03050	COG4786	Flagellar basal body rod
CTN_RS03050	COG1256	bacterial-type flagellum assembly
CTN_RS03050	COG4786	Flagellar basal body rod
CTN_RS03055	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CTN_RS03060	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
CTN_RS03065	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CTN_RS03070	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CTN_RS03075	COG1120	ATPase activity
CTN_RS03080	COG3458	cephalosporin-C deacetylase activity
CTN_RS03085	COG1472	Belongs to the glycosyl hydrolase 3 family
CTN_RS03095	COG4608	Belongs to the ABC transporter superfamily
CTN_RS03100	COG0444	Belongs to the ABC transporter superfamily
CTN_RS03105	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CTN_RS03110	COG0601	transmembrane transport
CTN_RS03125	COG1312	Catalyzes the dehydration of D-mannonate
CTN_RS03130	COG0246	Mannitol dehydrogenase
CTN_RS03145	COG1414	Transcriptional regulator
CTN_RS03150	COG1904	glucuronate isomerase
CTN_RS03165	COG0675	Transposase, IS605 OrfB family
CTN_RS03170	COG0601	transmembrane transport
CTN_RS03175	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CTN_RS03180	COG0444	Belongs to the ABC transporter superfamily
CTN_RS03185	COG4608	Belongs to the ABC transporter superfamily
CTN_RS03190	COG4166	transmembrane transport
CTN_RS03195	COG3661	Belongs to the glycosyl hydrolase 67 family
CTN_RS03215	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
CTN_RS03215	COG1918	ferrous iron import across plasma membrane
CTN_RS03225	COG2006	4fe-4S ferredoxin, iron-sulfur binding domain protein
CTN_RS03240	COG1132	(ABC) transporter
CTN_RS03245	COG0006	proline dipeptidase activity
CTN_RS03250	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
CTN_RS03250	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
CTN_RS03255	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
CTN_RS03260	COG1469	GTP cyclohydrolase I activity
CTN_RS03265	COG0720	synthase
CTN_RS03295	COG1653	transport
CTN_RS03300	COG1175	transmembrane transport
CTN_RS03305	COG0395	ABC-type sugar transport system, permease component
CTN_RS03315	COG4166	transmembrane transport
CTN_RS03320	COG0601	transmembrane transport
CTN_RS03330	COG4608	Belongs to the ABC transporter superfamily
CTN_RS03335	COG4608	Belongs to the ABC transporter superfamily
CTN_RS03345	COG1472	Belongs to the glycosyl hydrolase 3 family
CTN_RS03355	COG0840	transmembrane signaling receptor activity
CTN_RS03360	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
CTN_RS03365	COG1993	acr, cog1993
CTN_RS03370	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
CTN_RS03380	COG1013	pyruvate-flavodoxin oxidoreductase activity
CTN_RS03385	COG0674	pyruvate-flavodoxin oxidoreductase activity
CTN_RS03390	COG1144	Oxidoreductase
CTN_RS03395	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
CTN_RS03400	COG0840	transmembrane signaling receptor activity
CTN_RS03435	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
CTN_RS03445	COG4948	Mandelate Racemase Muconate Lactonizing
CTN_RS03475	COG1353	crispr-associated protein
CTN_RS03535	COG1518	maintenance of DNA repeat elements
CTN_RS03540	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
CTN_RS03555	COG2115	Belongs to the xylose isomerase family
CTN_RS03560	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CTN_RS03570	COG2813	Specifically methylates the guanine in position
CTN_RS03575	COG1122	ATPase activity
CTN_RS03580	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
CTN_RS03585	COG0242	peptide deformylase activity
CTN_RS03600	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
CTN_RS03605	COG0268	Binds directly to 16S ribosomal RNA
CTN_RS03615	COG0745	RESPONSE REGULATOR receiver
CTN_RS03620	COG5002	protein histidine kinase activity
CTN_RS03635	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CTN_RS03650	COG1713	HD superfamily hydrolase involved in NAD metabolism
CTN_RS03670	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
CTN_RS03675	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
CTN_RS03690	COG0525	valine-tRNA ligase activity
CTN_RS03695	COG2059	Chromate
CTN_RS03710	COG1059	Responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine 7-oxoG) from DNA. Also nicks DNA at apurinic apyrimidinic sites (AP sites)
CTN_RS03715	COG0330	HflC and HflK could
CTN_RS03720	COG0330	HflC and HflK could
CTN_RS03730	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
CTN_RS03735	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CTN_RS03735	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CTN_RS03740	COG0307	riboflavin synthase, alpha
CTN_RS03745	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CTN_RS03745	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CTN_RS03760	COG3833	ABC-type maltose transport systems, permease component
CTN_RS03765	COG1175	transmembrane transport
CTN_RS03775	COG0366	Alpha amylase catalytic
CTN_RS03795	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
CTN_RS03800	COG1523	belongs to the glycosyl hydrolase 13 family
CTN_RS03810	COG1940	carbohydrate kinase activity
CTN_RS03815	COG1129	ABC transporter
CTN_RS03820	COG1172	Belongs to the binding-protein-dependent transport system permease family
CTN_RS03840	COG1653	transport
CTN_RS03850	COG2723	6-phospho-beta-galactosidase activity
CTN_RS03855	COG3459	Glycosyltransferase 36 associated
CTN_RS03880	COG0395	ABC-type sugar transport system, permease component
CTN_RS03885	COG1175	transmembrane transport
CTN_RS03900	COG1418	mRNA catabolic process
CTN_RS03910	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
CTN_RS03915	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
CTN_RS03920	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CTN_RS03940	COG1515	deoxyribonuclease V activity
CTN_RS03955	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
CTN_RS03960	COG1067	ATP-dependent peptidase activity
CTN_RS03965	COG2894	cell division
CTN_RS03975	COG0432	Pfam Uncharacterised protein family UPF0047
CTN_RS03985	COG1278	Cold shock
CTN_RS04005	COG0737	Belongs to the 5'-nucleotidase family
CTN_RS04010	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
CTN_RS04010	COG0540	Belongs to the ATCase OTCase family
CTN_RS04015	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
CTN_RS04025	COG0543	2 iron, 2 sulfur cluster binding
CTN_RS04040	COG0419	ATPase involved in DNA repair
CTN_RS04055	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
CTN_RS04060	COG0802	atpase or kinase
CTN_RS04075	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
CTN_RS04080	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CTN_RS04085	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
CTN_RS04090	COG0193	aminoacyl-tRNA hydrolase activity
CTN_RS04100	COG3250	beta-galactosidase activity
CTN_RS04105	COG0481	GTPase activity
CTN_RS04115	COG0584	glycerophosphoryl diester phosphodiesterase
CTN_RS04125	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CTN_RS04125	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CTN_RS04130	COG1406	Chemotaxis phosphatase CheX
CTN_RS04145	COG0356	it plays a direct role in the translocation of protons across the membrane
CTN_RS04150	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CTN_RS04155	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
CTN_RS04160	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CTN_RS04165	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
CTN_RS04170	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
CTN_RS04175	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
CTN_RS04180	COG0355	proton-transporting ATP synthase activity, rotational mechanism
CTN_RS04185	COG1307	EDD domain protein, DegV family
CTN_RS04195	COG1530	ribonuclease E activity
CTN_RS04200	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
CTN_RS04205	COG0528	UMP kinase activity
CTN_RS04210	COG0477	Major facilitator Superfamily
CTN_RS04215	COG1827	regulation of RNA biosynthetic process
CTN_RS04220	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CTN_RS04235	COG1595	DNA-templated transcription, initiation
CTN_RS04250	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
CTN_RS04260	COG0489	protein tyrosine kinase activity
CTN_RS04265	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
CTN_RS04270	COG0291	Belongs to the bacterial ribosomal protein bL35 family
CTN_RS04275	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
CTN_RS04295	COG1278	Cold shock
CTN_RS04305	COG1185	polyribonucleotide nucleotidyltransferase activity
CTN_RS04310	COG1376	ErfK ybiS ycfS ynhG family protein
CTN_RS04315	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
CTN_RS04320	COG1758	RNA polymerase activity
CTN_RS04325	COG0194	GDP metabolic process
CTN_RS04330	COG2052	Domain of unknown function (DUF370)
CTN_RS04335	COG1561	YicC-like family, N-terminal region
CTN_RS04350	COG0301	tRNA thio-modification
CTN_RS04365	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
CTN_RS04375	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
CTN_RS04405	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
CTN_RS04410	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CTN_RS04415	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
CTN_RS04425	COG0391	Required for morphogenesis under gluconeogenic growth conditions
CTN_RS04430	COG1660	Displays ATPase and GTPase activities
CTN_RS04445	COG1739	Uncharacterized protein family UPF0029
CTN_RS04455	COG0820	rRNA (adenine-C2-)-methyltransferase activity
CTN_RS04465	COG1162	GTPase activity
CTN_RS04470	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
CTN_RS04475	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
CTN_RS04500	COG1028	Short-chain dehydrogenase reductase Sdr
CTN_RS04520	COG1269	ATP hydrolysis coupled proton transport
CTN_RS04540	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
CTN_RS04545	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
CTN_RS04550	COG1394	ATPase activity, coupled to movement of substances
CTN_RS04565	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
CTN_RS04575	COG2255	four-way junction helicase activity
CTN_RS04580	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
CTN_RS04590	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
CTN_RS04595	COG0704	Plays a role in the regulation of phosphate uptake
CTN_RS04605	COG0305	Participates in initiation and elongation during chromosome replication
CTN_RS04610	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
CTN_RS04625	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
CTN_RS04630	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CTN_RS04635	COG0647	UMP catabolic process
CTN_RS04640	COG0667	Aldo Keto reductase
CTN_RS04645	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
CTN_RS04655	COG3426	butyrate kinase activity
CTN_RS04660	COG0280	phosphate acetyltransferase
CTN_RS04665	COG3426	butyrate kinase activity
CTN_RS04695	COG0556	nucleotide-excision repair
CTN_RS04705	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
CTN_RS04715	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CTN_RS04720	COG2759	Belongs to the formate--tetrahydrofolate ligase family
CTN_RS04725	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
CTN_RS04730	COG1570	exodeoxyribonuclease VII activity
CTN_RS04735	COG1722	exodeoxyribonuclease VII activity
CTN_RS04740	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
CTN_RS04760	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
CTN_RS04770	COG0735	belongs to the Fur family
CTN_RS04775	COG0195	Participates in both transcription termination and antitermination
CTN_RS04780	COG0779	Required for maturation of 30S ribosomal subunits
CTN_RS04795	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
CTN_RS04805	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CTN_RS04810	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
CTN_RS04815	COG2171	N-acyltransferase activity
CTN_RS04825	COG0019	diaminopimelate decarboxylase activity
CTN_RS04830	COG1473	amidohydrolase
CTN_RS04845	COG1323	Belongs to the UPF0348 family
CTN_RS04850	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CTN_RS04850	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CTN_RS04855	COG2738	Putative neutral zinc metallopeptidase
CTN_RS04865	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
CTN_RS04870	COG1480	7TM receptor with intracellular HD hydrolase
CTN_RS04875	COG1702	phosphate starvation-inducible protein PhoH
CTN_RS04885	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
CTN_RS04890	COG0049	tRNA binding
CTN_RS04895	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CTN_RS04900	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CTN_RS04905	COG0051	transcription antitermination factor activity, RNA binding
CTN_RS04910	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
CTN_RS04915	COG0088	Forms part of the polypeptide exit tunnel
CTN_RS04920	COG0089	rRNA binding
CTN_RS04925	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
CTN_RS04930	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
CTN_RS04935	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
CTN_RS04940	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
CTN_RS04945	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
CTN_RS04950	COG0255	Belongs to the universal ribosomal protein uL29 family
CTN_RS04955	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
CTN_RS04960	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
CTN_RS04965	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
CTN_RS04975	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
CTN_RS04980	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
CTN_RS04985	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
CTN_RS04990	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
CTN_RS04995	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
CTN_RS05000	COG1841	ribosomal large subunit assembly
CTN_RS05005	COG0200	Binds to the 23S rRNA
CTN_RS05010	COG0201	protein transport
CTN_RS05015	COG0563	adenylate kinase activity
CTN_RS05020	COG0024	Methionine aminopeptidase
CTN_RS05025	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
CTN_RS05030	COG0257	Belongs to the bacterial ribosomal protein bL36 family
CTN_RS05035	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
CTN_RS05040	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
CTN_RS05045	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
CTN_RS05050	COG0202	RNA polymerase activity
CTN_RS05055	COG0203	ribosomal protein L17
CTN_RS05060	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
CTN_RS05070	COG1307	EDD domain protein, DegV family
CTN_RS05085	COG0218	Necessary for normal cell division and for the maintenance of normal septation
CTN_RS05090	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
CTN_RS05095	COG2313	pseudouridylate synthase activity
CTN_RS05100	COG0230	Belongs to the bacterial ribosomal protein bL34 family
CTN_RS05105	COG0594	ribonuclease P activity
CTN_RS05110	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
CTN_RS05115	COG0706	membrane insertase activity
CTN_RS05130	COG0261	This protein binds to 23S rRNA in the presence of protein L20
CTN_RS05140	COG0211	Belongs to the bacterial ribosomal protein bL27 family
CTN_RS05145	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
CTN_RS05150	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
CTN_RS05155	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
CTN_RS05160	COG0358	DNA primase activity
CTN_RS05165	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CTN_RS05170	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
CTN_RS05175	COG3063	Type IV pilus biogenesis stability protein PilW
CTN_RS05185	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
CTN_RS05190	COG1160	GTP binding
CTN_RS05195	COG2183	response to ionizing radiation
CTN_RS05195	COG0539	negative regulation of cytoplasmic translation
CTN_RS05200	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
CTN_RS05205	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
CTN_RS05210	COG1366	Belongs to the anti-sigma-factor antagonist family
CTN_RS05215	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
CTN_RS05220	COG2050	protein possibly involved in aromatic compounds catabolism
CTN_RS05220	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
CTN_RS05235	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
CTN_RS05265	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
CTN_RS05275	COG0840	transmembrane signaling receptor activity
CTN_RS05280	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
CTN_RS05310	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
CTN_RS05325	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CTN_RS05325	COG1213	nucleotidyl transferase
CTN_RS05335	COG0719	Fe-S assembly protein
CTN_RS05345	COG0483	inositol monophosphate 1-phosphatase activity
CTN_RS05350	COG1621	beta-fructofuranosidase activity
CTN_RS05370	COG0438	transferase activity, transferring glycosyl groups
CTN_RS05375	COG2342	PFAM TM1410 hypothetical-related protein
CTN_RS05400	COG0438	transferase activity, transferring glycosyl groups
CTN_RS05405	COG3437	response regulator, receiver
CTN_RS05435	COG1434	Gram-negative-bacterium-type cell wall biogenesis
CTN_RS05445	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CTN_RS05520	COG1959	2 iron, 2 sulfur cluster binding
CTN_RS05525	COG1575	Belongs to the MenA family. Type 1 subfamily
CTN_RS05535	COG2086	electron transfer activity
CTN_RS05540	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
CTN_RS05545	COG0644	oxidoreductase
CTN_RS05570	COG1032	radical SAM domain protein
CTN_RS05580	COG1706	bacterial-type flagellum-dependent cell motility
CTN_RS05585	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
CTN_RS05600	COG4786	Flagellar basal body rod
CTN_RS05615	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
CTN_RS05615	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
CTN_RS05620	COG1078	dGTPase activity
CTN_RS05630	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CTN_RS05635	COG3872	metal-dependent enzyme
CTN_RS05640	COG2078	PFAM AMMECR1 domain protein
CTN_RS05650	COG1477	protein flavinylation
CTN_RS05670	COG2003	Belongs to the UPF0758 family
CTN_RS05675	COG1418	mRNA catabolic process
CTN_RS05680	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
CTN_RS05690	COG0343	queuine tRNA-ribosyltransferase activity
CTN_RS05700	COG0668	transmembrane transport
CTN_RS05705	COG1254	Belongs to the acylphosphatase family
CTN_RS05710	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
CTN_RS05715	COG0228	four-way junction DNA binding
CTN_RS05720	COG1837	Belongs to the UPF0109 family
CTN_RS05725	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
CTN_RS05730	COG0336	Belongs to the RNA methyltransferase TrmD family
CTN_RS05735	COG4752	Belongs to the RNA methyltransferase TrmD family
CTN_RS05740	COG0335	large ribosomal subunit rRNA binding
CTN_RS05745	COG0681	Belongs to the peptidase S26 family
CTN_RS05755	COG0101	tRNA pseudouridine synthase activity
CTN_RS05765	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
CTN_RS05775	COG0653	protein targeting
CTN_RS05805	COG1040	competence protein
CTN_RS05810	COG2379	hydroxypyruvate reductase
CTN_RS05825	COG2199	diguanylate cyclase activity
CTN_RS05885	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
CTN_RS05890	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
CTN_RS05895	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
CTN_RS05900	COG0165	Argininosuccinate lyase
CTN_RS05905	COG0137	argininosuccinate synthase activity
CTN_RS05925	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CTN_RS05930	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
CTN_RS05935	COG0233	cytoplasmic translational termination
CTN_RS05940	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
CTN_RS05945	COG0575	Belongs to the CDS family
CTN_RS05950	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CTN_RS05960	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
CTN_RS05965	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
CTN_RS05975	COG0542	response to heat
CTN_RS06000	COG0742	ribosomal rna small subunit methyltransferase
CTN_RS06005	COG0237	dephospho-CoA kinase activity
CTN_RS06015	COG0166	Belongs to the GPI family
CTN_RS06020	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CTN_RS06045	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
CTN_RS06050	COG1177	transmembrane transport
CTN_RS06060	COG3842	ATPase activity
CTN_RS06065	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
CTN_RS06075	COG0406	alpha-ribazole phosphatase activity
CTN_RS06085	COG0822	iron-sulfur transferase activity
CTN_RS06090	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CTN_RS06095	COG1372	Participates in initiation and elongation during chromosome replication
CTN_RS06095	COG0719	Fe-S assembly protein
CTN_RS06100	COG0719	Fe-S assembly protein
CTN_RS06105	COG0396	ATPase activity
CTN_RS06120	COG1677	Flagellar hook-basal body complex protein FliE
CTN_RS06125	COG1558	bacterial-type flagellum-dependent cell motility
CTN_RS06130	COG1815	bacterial-type flagellum-dependent cell motility
CTN_RS06135	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
CTN_RS06145	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
CTN_RS06150	COG0745	RESPONSE REGULATOR receiver
CTN_RS06155	COG3852	Histidine kinase
CTN_RS06180	COG0516	GMP reductase activity
CTN_RS06180	COG0517	IMP dehydrogenase activity
CTN_RS06195	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CTN_RS06200	COG2267	carboxylic ester hydrolase activity
CTN_RS06205	COG0628	permease
CTN_RS06215	COG0516	GMP reductase activity
CTN_RS06215	COG0517	IMP dehydrogenase activity
CTN_RS06220	COG0612	Peptidase, M16
CTN_RS06225	COG1185	polyribonucleotide nucleotidyltransferase activity
CTN_RS06230	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
CTN_RS06285	COG4555	ABC transporter
CTN_RS06300	COG0641	radical SAM
CTN_RS06330	COG1598	PFAM Uncharacterised protein family UPF0150
CTN_RS06340	COG1132	(ABC) transporter
CTN_RS06345	COG1132	(ABC) transporter
CTN_RS06355	COG0457	Tetratricopeptide repeat
CTN_RS06360	COG1598	PFAM Uncharacterised protein family UPF0150
CTN_RS06370	COG1598	PFAM Uncharacterised protein family UPF0150
CTN_RS06375	COG1132	(ABC) transporter
CTN_RS06400	COG4555	ABC transporter
CTN_RS06420	COG0667	Aldo Keto reductase
CTN_RS06435	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CTN_RS06450	COG0662	Cupin 2, conserved barrel domain protein
CTN_RS06455	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
CTN_RS06460	COG1486	melibiose metabolic process
CTN_RS06475	COG1193	negative regulation of DNA recombination
CTN_RS06485	COG3842	ATPase activity
CTN_RS06500	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CTN_RS06505	COG0154	amidase activity
CTN_RS06510	COG2165	general secretion pathway protein
CTN_RS06520	COG0626	cystathionine gamma-synthase activity
CTN_RS06525	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
CTN_RS06560	COG0573	inorganic phosphate transmembrane transporter activity
CTN_RS06565	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CTN_RS06570	COG0704	Plays a role in the regulation of phosphate uptake
CTN_RS06575	COG0745	RESPONSE REGULATOR receiver
CTN_RS06580	COG5002	protein histidine kinase activity
CTN_RS06590	COG1132	(ABC) transporter
CTN_RS06595	COG0436	Aminotransferase
CTN_RS06600	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CTN_RS06605	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CTN_RS06605	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
CTN_RS06615	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
CTN_RS06620	COG0151	Belongs to the GarS family
CTN_RS06625	COG0138	bifunctional purine biosynthesis protein purh
CTN_RS06630	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
CTN_RS06635	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
CTN_RS06640	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CTN_RS06645	COG0047	phosphoribosylformylglycinamidine synthase activity
CTN_RS06650	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CTN_RS06670	COG0012	GTP binding
CTN_RS06680	COG0210	DNA helicase
CTN_RS06705	COG3842	ATPase activity
CTN_RS06710	COG0383	alpha-mannosidase activity
CTN_RS06715	COG0438	transferase activity, transferring glycosyl groups
CTN_RS06720	COG0463	Glycosyl transferase, family 2
CTN_RS06735	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
CTN_RS06740	COG1940	carbohydrate kinase activity
CTN_RS06745	COG4166	transmembrane transport
CTN_RS06750	COG0601	transmembrane transport
CTN_RS06755	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CTN_RS06760	COG0444	Belongs to the ABC transporter superfamily
CTN_RS06765	COG4608	Belongs to the ABC transporter superfamily
CTN_RS06780	COG0649	NAD binding
CTN_RS06785	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CTN_RS06785	COG0649	NAD binding
CTN_RS06790	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CTN_RS06800	COG0651	ATP synthesis coupled electron transport
CTN_RS06805	COG0651	ATP synthesis coupled electron transport
CTN_RS06810	COG1006	Multisubunit Na H antiporter MnhC subunit
CTN_RS06815	COG2111	Na H antiporter
CTN_RS06815	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CTN_RS06830	COG2212	antiporter activity
CTN_RS06835	COG1863	multisubunit Na H antiporter MnhE subunit
CTN_RS06840	COG2182	Extracellular solute-binding protein
CTN_RS06845	COG1175	transmembrane transport
CTN_RS06850	COG3833	ABC-type maltose transport systems, permease component
CTN_RS06870	COG1175	transmembrane transport
CTN_RS06875	COG0395	ABC-type sugar transport system, permease component
CTN_RS06890	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CTN_RS06905	COG0444	Belongs to the ABC transporter superfamily
CTN_RS06915	COG3345	alpha-galactosidase
CTN_RS06920	COG1085	galactose-1-phosphate uridylyltransferase
CTN_RS06925	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
CTN_RS06935	COG2199	diguanylate cyclase activity
CTN_RS06950	COG0628	permease
CTN_RS06960	COG1803	Methylglyoxal synthase
CTN_RS06970	COG0667	Aldo Keto reductase
CTN_RS06975	COG1196	nuclear chromosome segregation
CTN_RS06980	COG0494	nUDIX hydrolase
CTN_RS07000	COG1011	Hydrolase
CTN_RS07020	COG1151	hydroxylamine reductase activity
CTN_RS07035	COG1028	Short-chain dehydrogenase reductase Sdr
CTN_RS07040	COG0058	SHG alpha-glucan phosphorylase activity
CTN_RS07050	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CTN_RS07055	COG1013	pyruvate-flavodoxin oxidoreductase activity
CTN_RS07060	COG0674	pyruvate-flavodoxin oxidoreductase activity
CTN_RS07060	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
CTN_RS07065	COG3706	GGDEF domain
CTN_RS07070	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
CTN_RS07075	COG2239	Acts as a magnesium transporter
CTN_RS07090	COG0010	Belongs to the arginase family
CTN_RS07105	COG1983	PspC domain protein
CTN_RS07110	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
CTN_RS07115	COG0363	glucosamine-6-phosphate deaminase activity
CTN_RS07120	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CTN_RS07125	COG0444	Belongs to the ABC transporter superfamily
CTN_RS07130	COG4608	Belongs to the ABC transporter superfamily
CTN_RS07135	COG0747	negative chemotaxis
CTN_RS07140	COG0601	transmembrane transport
CTN_RS07155	COG0785	Cytochrome C biogenesis protein
CTN_RS07160	COG0516	GMP reductase activity
CTN_RS07160	COG0517	IMP dehydrogenase activity
CTN_RS07200	COG0714	Associated with various cellular activities
CTN_RS07205	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CTN_RS07210	COG0280	phosphate acetyltransferase
CTN_RS07215	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
CTN_RS07245	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
CTN_RS07320	COG0651	ATP synthesis coupled electron transport
CTN_RS07325	COG1006	Multisubunit Na H antiporter MnhC subunit
CTN_RS07330	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CTN_RS07335	COG0571	ribonuclease III activity
CTN_RS07350	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
CTN_RS07355	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
CTN_RS07360	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
CTN_RS07365	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
CTN_RS07370	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CTN_RS07375	COG0018	arginyl-trna synthetase
CTN_RS07390	COG0124	histidyl-tRNA synthetase
CTN_RS07420	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CTN_RS07420	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CTN_RS07425	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CTN_RS07430	COG1371	PFAM Archease protein family (DUF101 UPF0211)
CTN_RS07435	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
CTN_RS07445	COG0698	ribose 5-phosphate isomerase
CTN_RS07450	COG2264	protein methyltransferase activity
CTN_RS07480	COG1070	Carbohydrate kinase
CTN_RS07490	COG4952	isomerase
CTN_RS07500	COG1349	DNA-binding transcription factor activity
CTN_RS07505	COG1486	melibiose metabolic process
CTN_RS07520	COG3250	beta-galactosidase activity
CTN_RS07535	COG2359	stage V sporulation protein S
CTN_RS07545	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CTN_RS07550	COG1324	tolerance protein
CTN_RS07555	COG1611	Belongs to the LOG family
CTN_RS07570	COG1555	photosystem II stabilization
CTN_RS07570	COG1596	polysaccharide export
CTN_RS07585	COG1363	Peptidase, m42
CTN_RS07595	COG0850	regulation of cytokinetic process
CTN_RS07610	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
CTN_RS07615	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
CTN_RS07620	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
CTN_RS07625	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CTN_RS07630	COG0131	Imidazoleglycerol-phosphate dehydratase
CTN_RS07635	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
CTN_RS07640	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
CTN_RS07645	COG0107	imidazoleglycerol-phosphate synthase activity
CTN_RS07650	COG0140	phosphoribosyl-ATP diphosphatase activity
CTN_RS07650	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
CTN_RS07655	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
CTN_RS07660	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
CTN_RS07660	COG0662	Cupin 2, conserved barrel domain protein
CTN_RS07680	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
CTN_RS07690	COG2211	Major facilitator Superfamily
CTN_RS07705	COG0395	ABC-type sugar transport system, permease component
CTN_RS07710	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
CTN_RS07720	COG2721	sulfolactate sulfo-lyase activity
CTN_RS07730	COG1012	belongs to the aldehyde dehydrogenase family
CTN_RS07740	COG1501	Belongs to the glycosyl hydrolase 31 family
CTN_RS07750	COG2186	Transcriptional regulator
CTN_RS07765	COG0840	transmembrane signaling receptor activity
CTN_RS07785	COG2814	Major facilitator Superfamily
CTN_RS07810	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
CTN_RS07840	COG0656	L-ascorbic acid biosynthetic process
CTN_RS07850	COG0667	Aldo Keto reductase
CTN_RS07855	COG2207	Transcriptional regulator
CTN_RS07885	COG1895	HEPN domain
CTN_RS07920	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CTN_RS07950	COG2373	Large extracellular alpha-helical protein
CTN_RS07955	COG0425	Belongs to the sulfur carrier protein TusA family
CTN_RS07960	COG2391	methyltransferase activity
CTN_RS07980	COG0425	Belongs to the sulfur carrier protein TusA family
CTN_RS08000	COG0840	transmembrane signaling receptor activity
CTN_RS08005	COG3706	GGDEF domain
CTN_RS08020	COG4974	Belongs to the 'phage' integrase family
CTN_RS08025	COG1606	tRNA processing
CTN_RS08030	COG1691	(AIR) carboxylase
CTN_RS08035	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
CTN_RS08050	COG1704	LemA family
CTN_RS08055	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CTN_RS08060	COG1869	D-ribose catabolic process
CTN_RS08075	COG1129	ABC transporter
CTN_RS08080	COG1172	Belongs to the binding-protein-dependent transport system permease family
CTN_RS08085	COG3959	Transketolase, thiamine diphosphate binding domain
CTN_RS08090	COG3958	Transketolase
CTN_RS08095	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
CTN_RS08140	COG0174	glutamine synthetase
CTN_RS08165	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
CTN_RS08180	COG0402	S-adenosylhomocysteine deaminase activity
CTN_RS08185	COG2239	Acts as a magnesium transporter
CTN_RS08190	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
CTN_RS08210	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
CTN_RS08215	COG3864	Putative metallopeptidase domain
CTN_RS08225	COG1141	Ferredoxin
CTN_RS08230	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
CTN_RS08235	COG0220	tRNA (guanine-N7-)-methyltransferase activity
CTN_RS08250	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
CTN_RS08250	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
CTN_RS08270	COG0840	transmembrane signaling receptor activity
CTN_RS08275	COG0306	phosphate transporter
CTN_RS08285	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
CTN_RS08290	COG1392	Phosphate transport regulator
CTN_RS08295	COG3956	TIGRFAM MazG family protein
CTN_RS08305	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
CTN_RS08310	COG1684	flagellar biosynthetic protein fliR
CTN_RS08315	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CTN_RS08320	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CTN_RS08325	COG1419	protein localization to endoplasmic reticulum
CTN_RS08340	COG1776	CheC inhibitor of MCP methylation
CTN_RS08345	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
CTN_RS08350	COG1191	sigma factor activity
CTN_RS08375	COG2359	stage V sporulation protein S
CTN_RS08395	COG1968	undecaprenyl-diphosphatase activity
CTN_RS08400	COG2239	Acts as a magnesium transporter
CTN_RS08405	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
CTN_RS08410	COG0750	zinc metalloprotease
CTN_RS08415	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
CTN_RS08425	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CTN_RS08430	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
CTN_RS08445	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
CTN_RS08450	COG2873	o-acetylhomoserine
CTN_RS08455	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
CTN_RS08460	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
CTN_RS08470	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
CTN_RS08470	COG0674	pyruvate-flavodoxin oxidoreductase activity
CTN_RS08475	COG0148	phosphopyruvate hydratase activity
CTN_RS08480	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
CTN_RS08490	COG1214	PFAM Peptidase M22, glycoprotease
CTN_RS08495	COG0542	response to heat
CTN_RS08500	COG0275	rRNA processing
CTN_RS08510	COG0768	penicillin binding
CTN_RS08515	COG0492	ferredoxin-NADP+ reductase activity
CTN_RS08540	COG1234	tRNA 3'-trailer cleavage
CTN_RS08545	COG0359	binds to the 23S rRNA
CTN_RS08555	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CTN_RS08560	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CTN_RS08565	COG1862	Preprotein translocase
CTN_RS08575	COG0196	riboflavin kinase activity
CTN_RS08580	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
CTN_RS08585	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
CTN_RS08590	COG1639	'signal transduction protein
CTN_RS08595	COG5002	protein histidine kinase activity
CTN_RS08600	COG0009	L-threonylcarbamoyladenylate synthase
CTN_RS08610	COG1420	regulation of RNA biosynthetic process
CTN_RS08615	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
CTN_RS08620	COG0484	heat shock protein binding
CTN_RS08625	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
CTN_RS08630	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
CTN_RS08635	COG0295	cytidine deaminase activity
CTN_RS08640	COG4535	Mg2 and Co2 transporter CorC
CTN_RS08645	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
CTN_RS08655	COG2201	protein-glutamate methylesterase activity
CTN_RS08670	COG0772	Belongs to the SEDS family
CTN_RS08680	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
CTN_RS08685	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
CTN_RS08690	COG0849	cell division
CTN_RS08700	COG0187	DNA topoisomerase II activity
CTN_RS08710	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CTN_RS08715	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CTN_RS08730	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CTN_RS08735	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
CTN_RS08750	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CTN_RS08750	COG0072	phenylalanine-tRNA ligase activity
CTN_RS08755	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
CTN_RS08765	COG1979	alcohol dehydrogenase
CTN_RS08775	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
CTN_RS08795	COG0534	Mate efflux family protein
CTN_RS08810	COG0395	ABC-type sugar transport system, permease component
CTN_RS08835	COG0450	alkyl hydroperoxide reductase
CTN_RS08845	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CTN_RS08850	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
CTN_RS08855	COG0504	CTP synthase activity
CTN_RS08860	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CTN_RS08865	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CTN_RS08870	COG2070	2-Nitropropane dioxygenase
CTN_RS08875	COG1268	BioY protein
CTN_RS08880	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
CTN_RS08885	COG2045	Belongs to the ComB family
CTN_RS08905	COG1131	(ABC) transporter
CTN_RS08910	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
CTN_RS08915	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
CTN_RS08920	COG1992	Thiamine-phosphate synthase
CTN_RS08920	COG0351	phosphomethylpyrimidine kinase
CTN_RS08930	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
CTN_RS08935	COG1635	Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur
CTN_RS09000	COG1774	PSP1 C-terminal conserved region
CTN_RS09005	COG0470	DNA polymerase III
CTN_RS09015	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CTN_RS09020	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
CTN_RS09025	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
CTN_RS09035	COG1131	(ABC) transporter
CTN_RS09045	COG1129	ABC transporter
CTN_RS09055	COG0393	Putative heavy-metal-binding
CTN_RS09060	COG0052	Belongs to the universal ribosomal protein uS2 family
CTN_RS09075	COG1181	Belongs to the D-alanine--D-alanine ligase family
CTN_RS09090	COG0457	Tetratricopeptide repeat
CTN_RS09090	COG0463	Glycosyl transferase, family 2
CTN_RS09105	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CTN_RS09110	COG2226	methyltransferase
CTN_RS09115	COG1486	melibiose metabolic process
CTN_RS09140	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
CTN_RS09145	COG0793	Belongs to the peptidase S41A family
CTN_RS09160	COG0438	transferase activity, transferring glycosyl groups
CTN_RS09170	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
CTN_RS09175	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
CTN_RS09180	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CTN_RS09185	COG2199	diguanylate cyclase activity
CTN_RS09185	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
CTN_RS09200	COG1482	cell wall glycoprotein biosynthetic process
CTN_RS09210	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
CTN_RS09225	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
CTN_RS09230	COG1490	D-aminoacyl-tRNA deacylase activity
CTN_RS09235	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CTN_RS09245	COG0312	modulator of DNA gyrase
CTN_RS09250	COG0312	modulator of DNA gyrase
CTN_RS09270	COG0557	exoribonuclease II activity
CTN_RS09275	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
CTN_RS09280	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CTN_RS09285	COG0215	cysteine-tRNA ligase activity
CTN_RS09290	COG0835	chemotaxis
CTN_RS09295	COG0511	ligase activity, forming carbon-carbon bonds
CTN_RS09305	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CTN_RS09310	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
CTN_RS09310	COG0617	tRNA 3'-terminal CCA addition
CTN_RS09310	COG3620	sequence-specific DNA binding
CTN_RS09340	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
CTN_RS09345	COG0095	Lipoate-protein ligase
CTN_RS09350	COG0357	Ribosomal RNA small subunit methyltransferase G
CTN_RS09365	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
CTN_RS09370	COG1546	Belongs to the CinA family
CTN_RS09370	COG1058	Belongs to the CinA family
CTN_RS09375	COG0643	Histidine kinase
CTN_RS09375	COG2198	Histidine kinase
CTN_RS09380	COG0835	chemotaxis
CTN_RS09385	COG2201	protein-glutamate methylesterase activity
CTN_RS09395	COG1338	Plays a role in the flagellum-specific transport system
CTN_RS09410	COG0740	serine-type endopeptidase activity
CTN_RS09415	COG0544	peptidyl-prolyl cis-trans isomerase activity
CTN_RS09425	COG0736	holo-[acyl-carrier-protein] synthase activity
CTN_RS09440	COG0149	triose-phosphate isomerase activity
CTN_RS09440	COG0126	phosphoglycerate kinase activity
CTN_RS09445	COG0149	triose-phosphate isomerase activity
CTN_RS09445	COG0126	phosphoglycerate kinase activity
CTN_RS09450	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
CTN_RS09455	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
CTN_RS09460	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
CTN_RS09490	COG1776	CheC inhibitor of MCP methylation
CTN_RS09490	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CTN_RS09495	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CTN_RS09505	COG1360	Flagellar Motor Protein
CTN_RS09515	COG1582	Flagellar protein (FlbD)
CTN_RS09555	COG0084	hydrolase, TatD family'
CTN_RS09560	COG1045	serine acetyltransferase
CTN_RS09565	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CTN_RS09580	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CTN_RS09590	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
CTN_RS09600	COG2033	superoxide reductase activity
CTN_RS09605	COG1592	Rubrerythrin