locus-tag	class	description
TSP02S_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
TSP02S_RS00010	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
TSP02S_RS00015	COG0840	transmembrane signaling receptor activity
TSP02S_RS00030	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
TSP02S_RS00035	COG0183	Belongs to the thiolase family
TSP02S_RS00040	COG2031	fatty acid transporter
TSP02S_RS00050	COG0697	spore germination
TSP02S_RS00060	COG1131	(ABC) transporter
TSP02S_RS00070	COG1073	alpha beta
TSP02S_RS00095	COG1802	Transcriptional regulator
TSP02S_RS00100	COG0393	Putative heavy-metal-binding
TSP02S_RS00105	COG0019	diaminopimelate decarboxylase activity
TSP02S_RS00110	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
TSP02S_RS00115	COG4120	Belongs to the binding-protein-dependent transport system permease family
TSP02S_RS00135	COG0483	inositol monophosphate 1-phosphatase activity
TSP02S_RS00145	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
TSP02S_RS00150	COG0218	Necessary for normal cell division and for the maintenance of normal septation
TSP02S_RS00165	COG0667	Aldo Keto reductase
TSP02S_RS00170	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
TSP02S_RS00175	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
TSP02S_RS00195	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
TSP02S_RS00200	COG2373	Large extracellular alpha-helical protein
TSP02S_RS00210	COG3234	Protein of unknown function (DUF1175)
TSP02S_RS00220	COG1032	radical SAM domain protein
TSP02S_RS00240	COG1609	Transcriptional regulator
TSP02S_RS00245	COG1178	ABC-type Fe3 transport system permease component
TSP02S_RS00250	COG4143	(ABC) transporter
TSP02S_RS00255	COG3481	metal-dependent phosphohydrolase, HD sub domain
TSP02S_RS00260	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
TSP02S_RS00265	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
TSP02S_RS00270	COG1757	Na H antiporter
TSP02S_RS00275	COG1523	belongs to the glycosyl hydrolase 13 family
TSP02S_RS00300	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
TSP02S_RS00310	COG0511	ligase activity, forming carbon-carbon bonds
TSP02S_RS00315	COG0835	chemotaxis
TSP02S_RS00320	COG0823	Involved in the tonB-independent uptake of proteins
TSP02S_RS00320	COG1506	peptidase
TSP02S_RS00330	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
TSP02S_RS00340	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
TSP02S_RS00350	COG0355	proton-transporting ATP synthase activity, rotational mechanism
TSP02S_RS00355	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
TSP02S_RS00360	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
TSP02S_RS00365	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
TSP02S_RS00370	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
TSP02S_RS00375	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
TSP02S_RS00380	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
TSP02S_RS00385	COG0356	it plays a direct role in the translocation of protons across the membrane
TSP02S_RS00400	COG1406	Chemotaxis phosphatase CheX
TSP02S_RS00405	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
TSP02S_RS00405	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
TSP02S_RS00420	COG1968	undecaprenyl-diphosphatase activity
TSP02S_RS00430	COG0174	glutamine synthetase
TSP02S_RS00445	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
TSP02S_RS00450	COG4166	transmembrane transport
TSP02S_RS00455	COG0601	transmembrane transport
TSP02S_RS00460	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TSP02S_RS00465	COG0444	Belongs to the ABC transporter superfamily
TSP02S_RS00470	COG4608	Belongs to the ABC transporter superfamily
TSP02S_RS00475	COG3345	alpha-galactosidase
TSP02S_RS00485	COG1609	Transcriptional regulator
TSP02S_RS00490	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
TSP02S_RS00490	COG0778	Nitroreductase
TSP02S_RS00495	COG2186	Transcriptional regulator
TSP02S_RS00500	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
TSP02S_RS00505	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
TSP02S_RS00510	COG1070	Carbohydrate kinase
TSP02S_RS00520	COG1879	ABC-type sugar transport system periplasmic component
TSP02S_RS00530	COG1129	ABC transporter
TSP02S_RS00540	COG1172	Belongs to the binding-protein-dependent transport system permease family
TSP02S_RS00545	COG2006	4fe-4S ferredoxin, iron-sulfur binding domain protein
TSP02S_RS00550	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
TSP02S_RS00580	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
TSP02S_RS00585	COG2176	DNA-directed DNA polymerase activity
TSP02S_RS00590	COG0622	Phosphoesterase
TSP02S_RS00595	COG0357	Ribosomal RNA small subunit methyltransferase G
TSP02S_RS00600	COG0095	Lipoate-protein ligase
TSP02S_RS00605	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
TSP02S_RS00630	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
TSP02S_RS00635	COG1385	rRNA (uridine-N3-)-methyltransferase activity
TSP02S_RS00655	COG3246	L-lysine catabolic process to acetate
TSP02S_RS00660	COG1607	acyl-coa hydrolase
TSP02S_RS00665	COG0697	spore germination
TSP02S_RS00680	COG0442	prolyl-tRNA aminoacylation
TSP02S_RS00685	COG0552	protein localization to endoplasmic reticulum
TSP02S_RS00715	COG1473	amidohydrolase
TSP02S_RS00720	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
TSP02S_RS00730	COG0205	6-phosphofructokinase activity
TSP02S_RS00735	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
TSP02S_RS00750	COG0546	phosphoglycolate phosphatase activity
TSP02S_RS00760	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
TSP02S_RS00765	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
TSP02S_RS00770	COG0509	glycine decarboxylation via glycine cleavage system
TSP02S_RS00775	COG0404	The glycine cleavage system catalyzes the degradation of glycine
TSP02S_RS00785	COG0205	6-phosphofructokinase activity
TSP02S_RS00790	COG0469	pyruvate kinase activity
TSP02S_RS00800	COG2313	pseudouridylate synthase activity
TSP02S_RS00805	COG0778	Nitroreductase
TSP02S_RS00815	COG1609	Transcriptional regulator
TSP02S_RS00820	COG2738	Putative neutral zinc metallopeptidase
TSP02S_RS00830	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
TSP02S_RS00835	COG1480	7TM receptor with intracellular HD hydrolase
TSP02S_RS00840	COG1702	phosphate starvation-inducible protein PhoH
TSP02S_RS00845	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
TSP02S_RS00850	COG0358	DNA primase activity
TSP02S_RS00855	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
TSP02S_RS00860	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
TSP02S_RS00865	COG0211	Belongs to the bacterial ribosomal protein bL27 family
TSP02S_RS00875	COG0261	This protein binds to 23S rRNA in the presence of protein L20
TSP02S_RS00895	COG0525	valine-tRNA ligase activity
TSP02S_RS00900	COG0285	dihydrofolate synthase activity
TSP02S_RS00905	COG0632	four-way junction helicase activity
TSP02S_RS00920	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
TSP02S_RS00930	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
TSP02S_RS00935	COG1196	nuclear chromosome segregation
TSP02S_RS00940	COG0494	nUDIX hydrolase
TSP02S_RS00950	COG1516	flagellar protein fliS
TSP02S_RS00960	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
TSP02S_RS00970	COG0768	penicillin binding
TSP02S_RS00990	COG4608	Belongs to the ABC transporter superfamily
TSP02S_RS00995	COG0444	Belongs to the ABC transporter superfamily
TSP02S_RS01000	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TSP02S_RS01005	COG0601	transmembrane transport
TSP02S_RS01015	COG0156	8-amino-7-oxononanoate synthase activity
TSP02S_RS01025	COG1461	Dihydroxyacetone kinase
TSP02S_RS01035	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
TSP02S_RS01045	COG1570	exodeoxyribonuclease VII activity
TSP02S_RS01050	COG1193	negative regulation of DNA recombination
TSP02S_RS01055	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
TSP02S_RS01075	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
TSP02S_RS01080	COG1368	sulfuric ester hydrolase activity
TSP02S_RS01085	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
TSP02S_RS01110	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
TSP02S_RS01115	COG1518	maintenance of DNA repeat elements
TSP02S_RS01145	COG0434	BtpA family
TSP02S_RS01155	COG3337	CRISPR-associated protein (Cas_Cmr5)
TSP02S_RS01195	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
TSP02S_RS01200	COG1518	maintenance of DNA repeat elements
TSP02S_RS01230	COG1337	RAMP superfamily
TSP02S_RS01240	COG1353	crispr-associated protein
TSP02S_RS01280	COG3181	Tripartite tricarboxylate transporter family receptor
TSP02S_RS01300	COG1940	carbohydrate kinase activity
TSP02S_RS01310	COG1737	Transcriptional regulator
TSP02S_RS01320	COG3584	3D domain protein
TSP02S_RS01325	COG1959	2 iron, 2 sulfur cluster binding
TSP02S_RS01330	COG1956	GAF domain-containing protein
TSP02S_RS01335	COG0019	diaminopimelate decarboxylase activity
TSP02S_RS01340	COG0432	Pfam Uncharacterised protein family UPF0047
TSP02S_RS01350	COG2894	cell division
TSP02S_RS01370	COG1175	transmembrane transport
TSP02S_RS01375	COG0395	ABC-type sugar transport system, permease component
TSP02S_RS01395	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
TSP02S_RS01415	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
TSP02S_RS01415	COG0540	Belongs to the ATCase OTCase family
TSP02S_RS01420	COG0300	oxidoreductase activity
TSP02S_RS01430	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
TSP02S_RS01435	COG0228	four-way junction DNA binding
TSP02S_RS01440	COG1837	Belongs to the UPF0109 family
TSP02S_RS01445	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
TSP02S_RS01450	COG0336	Belongs to the RNA methyltransferase TrmD family
TSP02S_RS01455	COG4752	Belongs to the RNA methyltransferase TrmD family
TSP02S_RS01460	COG0335	large ribosomal subunit rRNA binding
TSP02S_RS01465	COG0681	Belongs to the peptidase S26 family
TSP02S_RS01470	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
TSP02S_RS01485	COG0395	ABC-type sugar transport system, permease component
TSP02S_RS01490	COG1175	transmembrane transport
TSP02S_RS01525	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
TSP02S_RS01560	COG0142	geranyltranstransferase activity
TSP02S_RS01580	COG1077	Cell shape determining protein MreB Mrl
TSP02S_RS01595	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
TSP02S_RS01600	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
TSP02S_RS01605	COG0459	protein refolding
TSP02S_RS01615	COG1846	Transcriptional regulator
TSP02S_RS01625	COG1803	Methylglyoxal synthase
TSP02S_RS01630	COG1228	amidohydrolase
TSP02S_RS01640	COG0747	negative chemotaxis
TSP02S_RS01650	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TSP02S_RS01655	COG0444	Belongs to the ABC transporter superfamily
TSP02S_RS01660	COG4608	Belongs to the ABC transporter superfamily
TSP02S_RS01685	COG2078	PFAM AMMECR1 domain protein
TSP02S_RS01690	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
TSP02S_RS01695	COG1477	protein flavinylation
TSP02S_RS01715	COG2003	Belongs to the UPF0758 family
TSP02S_RS01730	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
TSP02S_RS01735	COG3404	Formiminotransferase-cyclodeaminase
TSP02S_RS01750	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
TSP02S_RS01760	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
TSP02S_RS01765	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
TSP02S_RS01770	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
TSP02S_RS01775	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
TSP02S_RS01780	COG0193	aminoacyl-tRNA hydrolase activity
TSP02S_RS01790	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
TSP02S_RS01795	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
TSP02S_RS01800	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
TSP02S_RS01805	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
TSP02S_RS01810	COG0626	cystathionine gamma-synthase activity
TSP02S_RS01820	COG0622	Phosphoesterase
TSP02S_RS01830	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
TSP02S_RS01835	COG1254	Belongs to the acylphosphatase family
TSP02S_RS01840	COG0516	GMP reductase activity
TSP02S_RS01840	COG0517	IMP dehydrogenase activity
TSP02S_RS01845	COG0751	glycine-tRNA ligase activity
TSP02S_RS01850	COG0752	glycyl-tRNA synthetase alpha subunit
TSP02S_RS01875	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
TSP02S_RS01880	COG0250	Participates in transcription elongation, termination and antitermination
TSP02S_RS01885	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
TSP02S_RS01890	COG0081	regulation of translation
TSP02S_RS01895	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
TSP02S_RS01900	COG0222	ribosome binding
TSP02S_RS01905	COG0085	RNA polymerase activity
TSP02S_RS01910	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
TSP02S_RS01915	COG0116	Belongs to the methyltransferase superfamily
TSP02S_RS01920	COG0312	modulator of DNA gyrase
TSP02S_RS01925	COG0312	modulator of DNA gyrase
TSP02S_RS01940	COG1126	abc transporter atp-binding protein
TSP02S_RS01950	COG0592	DNA-directed DNA polymerase activity
TSP02S_RS01980	COG1515	deoxyribonuclease V activity
TSP02S_RS01985	COG1454	alcohol dehydrogenase
TSP02S_RS01995	COG0436	Aminotransferase
TSP02S_RS02000	COG0728	peptidoglycan biosynthetic process
TSP02S_RS02005	COG1355	regulation of microtubule-based process
TSP02S_RS02040	COG1459	type II secretion system
TSP02S_RS02065	COG0673	inositol 2-dehydrogenase activity
TSP02S_RS02070	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
TSP02S_RS02080	COG2379	hydroxypyruvate reductase
TSP02S_RS02090	COG1970	mechanosensitive ion channel activity
TSP02S_RS02095	COG2414	aldehyde ferredoxin oxidoreductase
TSP02S_RS02115	COG1609	Transcriptional regulator
TSP02S_RS02120	COG1129	ABC transporter
TSP02S_RS02135	COG0395	ABC-type sugar transport system, permease component
TSP02S_RS02140	COG1175	transmembrane transport
TSP02S_RS02150	COG1070	Carbohydrate kinase
TSP02S_RS02160	COG3458	cephalosporin-C deacetylase activity
TSP02S_RS02165	COG1472	Belongs to the glycosyl hydrolase 3 family
TSP02S_RS02170	COG4608	Belongs to the ABC transporter superfamily
TSP02S_RS02175	COG0444	Belongs to the ABC transporter superfamily
TSP02S_RS02180	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TSP02S_RS02185	COG0601	transmembrane transport
TSP02S_RS02195	COG1129	ABC transporter
TSP02S_RS02200	COG1879	ABC-type sugar transport system periplasmic component
TSP02S_RS02205	COG1172	Belongs to the binding-protein-dependent transport system permease family
TSP02S_RS02215	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TSP02S_RS02215	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TSP02S_RS02220	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
TSP02S_RS02230	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
TSP02S_RS02235	COG1366	Belongs to the anti-sigma-factor antagonist family
TSP02S_RS02240	COG0698	ribose 5-phosphate isomerase
TSP02S_RS02260	COG1079	Belongs to the binding-protein-dependent transport system permease family
TSP02S_RS02265	COG4603	Belongs to the binding-protein-dependent transport system permease family
TSP02S_RS02270	COG1129	ABC transporter
TSP02S_RS02280	COG3906	Belongs to the UPF0473 family
TSP02S_RS02285	COG2188	Transcriptional regulator
TSP02S_RS02295	COG1032	radical SAM domain protein
TSP02S_RS02305	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
TSP02S_RS02310	COG1196	nuclear chromosome segregation
TSP02S_RS02320	COG1704	LemA family
TSP02S_RS02325	COG0501	Belongs to the peptidase M48B family
TSP02S_RS02330	COG2998	abc-type tungstate transport system, permease component
TSP02S_RS02350	COG3875	lactate racemase activity
TSP02S_RS02355	COG2721	sulfolactate sulfo-lyase activity
TSP02S_RS02365	COG0281	malic enzyme
TSP02S_RS02390	COG1181	Belongs to the D-alanine--D-alanine ligase family
TSP02S_RS02405	COG2267	carboxylic ester hydrolase activity
TSP02S_RS02410	COG0360	Binds together with S18 to 16S ribosomal RNA
TSP02S_RS02415	COG0629	single-stranded DNA binding
TSP02S_RS02420	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
TSP02S_RS02440	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
TSP02S_RS02445	COG1129	ABC transporter
TSP02S_RS02450	COG1172	Belongs to the binding-protein-dependent transport system permease family
TSP02S_RS02455	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
TSP02S_RS02465	COG1070	Carbohydrate kinase
TSP02S_RS02470	COG1869	D-ribose catabolic process
TSP02S_RS02475	COG0667	Aldo Keto reductase
TSP02S_RS02480	COG2188	Transcriptional regulator
TSP02S_RS02485	COG1012	belongs to the aldehyde dehydrogenase family
TSP02S_RS02490	COG2140	Oxalate decarboxylase
TSP02S_RS02515	COG2359	stage V sporulation protein S
TSP02S_RS02530	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
TSP02S_RS02535	COG0815	Transfers the fatty acyl group on membrane lipoproteins
TSP02S_RS02540	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
TSP02S_RS02575	COG2006	4fe-4S ferredoxin, iron-sulfur binding domain protein
TSP02S_RS02580	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
TSP02S_RS02595	COG4717	serine-type aminopeptidase activity
TSP02S_RS02610	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
TSP02S_RS02625	COG1131	(ABC) transporter
TSP02S_RS02640	COG0667	Aldo Keto reductase
TSP02S_RS02655	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
TSP02S_RS02670	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
TSP02S_RS02685	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
TSP02S_RS02695	COG0084	hydrolase, TatD family'
TSP02S_RS02715	COG0450	alkyl hydroperoxide reductase
TSP02S_RS02720	COG1528	Iron-storage protein
TSP02S_RS02730	COG2151	metal-sulfur cluster biosynthetic enzyme
TSP02S_RS02735	COG2890	protein-(glutamine-N5) methyltransferase activity
TSP02S_RS02740	COG1132	(ABC) transporter
TSP02S_RS02750	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
TSP02S_RS02765	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
TSP02S_RS02770	COG1160	GTP binding
TSP02S_RS02775	COG2183	response to ionizing radiation
TSP02S_RS02775	COG0539	negative regulation of cytoplasmic translation
TSP02S_RS02780	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
TSP02S_RS02785	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
TSP02S_RS02790	COG1366	Belongs to the anti-sigma-factor antagonist family
TSP02S_RS02795	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
TSP02S_RS02815	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
TSP02S_RS02835	COG0151	Belongs to the GarS family
TSP02S_RS02840	COG0138	bifunctional purine biosynthesis protein purh
TSP02S_RS02845	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
TSP02S_RS02850	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
TSP02S_RS02855	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
TSP02S_RS02860	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
TSP02S_RS02865	COG0047	phosphoribosylformylglycinamidine synthase activity
TSP02S_RS02870	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
TSP02S_RS02875	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
TSP02S_RS02880	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
TSP02S_RS02895	COG3718	enzyme involved in inositol metabolism
TSP02S_RS02910	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
TSP02S_RS02915	COG1414	Transcriptional regulator
TSP02S_RS02925	COG1028	Short-chain dehydrogenase reductase Sdr
TSP02S_RS02930	COG3718	enzyme involved in inositol metabolism
TSP02S_RS02950	COG0714	Associated with various cellular activities
TSP02S_RS02960	COG0383	alpha-mannosidase activity
TSP02S_RS02970	COG3842	ATPase activity
TSP02S_RS02975	COG0395	ABC-type sugar transport system, permease component
TSP02S_RS02980	COG1175	transmembrane transport
TSP02S_RS02990	COG1609	Transcriptional regulator
TSP02S_RS02995	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
TSP02S_RS03000	COG4608	Belongs to the ABC transporter superfamily
TSP02S_RS03005	COG0444	Belongs to the ABC transporter superfamily
TSP02S_RS03010	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TSP02S_RS03015	COG0601	transmembrane transport
TSP02S_RS03020	COG0747	negative chemotaxis
TSP02S_RS03025	COG0747	negative chemotaxis
TSP02S_RS03035	COG2252	PERMEase
TSP02S_RS03040	COG1131	(ABC) transporter
TSP02S_RS03070	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
TSP02S_RS03075	COG0750	zinc metalloprotease
TSP02S_RS03080	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
TSP02S_RS03095	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
TSP02S_RS03120	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
TSP02S_RS03125	COG0792	nuclease activity
TSP02S_RS03130	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
TSP02S_RS03135	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
TSP02S_RS03140	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
TSP02S_RS03145	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
TSP02S_RS03150	COG1256	bacterial-type flagellum assembly
TSP02S_RS03150	COG4786	Flagellar basal body rod
TSP02S_RS03150	COG4786	Flagellar basal body rod
TSP02S_RS03150	COG1256	bacterial-type flagellum assembly
TSP02S_RS03165	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
TSP02S_RS03175	COG3845	ABC transporter
TSP02S_RS03180	COG4603	Belongs to the binding-protein-dependent transport system permease family
TSP02S_RS03185	COG1079	Belongs to the binding-protein-dependent transport system permease family
TSP02S_RS03200	COG0037	tRNA processing
TSP02S_RS03205	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
TSP02S_RS03240	COG0196	riboflavin kinase activity
TSP02S_RS03245	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
TSP02S_RS03250	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
TSP02S_RS03255	COG1639	'signal transduction protein
TSP02S_RS03265	COG0668	transmembrane transport
TSP02S_RS03270	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
TSP02S_RS03275	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
TSP02S_RS03280	COG1131	(ABC) transporter
TSP02S_RS03290	COG1363	Peptidase, m42
TSP02S_RS03295	COG0730	response to heat
TSP02S_RS03325	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
TSP02S_RS03360	COG1773	rubredoxin
TSP02S_RS03365	COG1268	BioY protein
TSP02S_RS03380	COG1410	methionine synthase
TSP02S_RS03380	COG0646	methionine synthase
TSP02S_RS03385	COG0460	homoserine dehydrogenase
TSP02S_RS03385	COG0527	aspartate kinase activity
TSP02S_RS03400	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
TSP02S_RS03420	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
TSP02S_RS03435	COG0850	regulation of cytokinetic process
TSP02S_RS03460	COG1555	photosystem II stabilization
TSP02S_RS03460	COG1596	polysaccharide export
TSP02S_RS03470	COG1137	ATPase activity
TSP02S_RS03480	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
TSP02S_RS03495	COG3250	beta-galactosidase activity
TSP02S_RS03505	COG3833	ABC-type maltose transport systems, permease component
TSP02S_RS03510	COG1175	transmembrane transport
TSP02S_RS03515	COG2182	Extracellular solute-binding protein
TSP02S_RS03520	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
TSP02S_RS03555	COG0165	Argininosuccinate lyase
TSP02S_RS03565	COG0395	ABC-type sugar transport system, permease component
TSP02S_RS03570	COG1175	transmembrane transport
TSP02S_RS03580	COG1940	carbohydrate kinase activity
TSP02S_RS03585	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
TSP02S_RS03590	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
TSP02S_RS03595	COG1482	cell wall glycoprotein biosynthetic process
TSP02S_RS03605	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
TSP02S_RS03610	COG2172	sigma factor antagonist activity
TSP02S_RS03620	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
TSP02S_RS03625	COG1490	D-aminoacyl-tRNA deacylase activity
TSP02S_RS03630	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
TSP02S_RS03635	COG0445	tRNA wobble uridine modification
TSP02S_RS03640	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
TSP02S_RS03645	COG0242	peptide deformylase activity
TSP02S_RS03650	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
TSP02S_RS03655	COG0101	tRNA pseudouridine synthase activity
TSP02S_RS03675	COG0653	protein targeting
TSP02S_RS03680	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
TSP02S_RS03690	COG0280	phosphate acetyltransferase
TSP02S_RS03710	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
TSP02S_RS03710	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
TSP02S_RS03715	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
TSP02S_RS03715	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
TSP02S_RS03725	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
TSP02S_RS03730	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
TSP02S_RS03740	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
TSP02S_RS03750	COG0737	Belongs to the 5'-nucleotidase family
TSP02S_RS03765	COG1104	cysteine desulfurase activity
TSP02S_RS03770	COG0822	iron-sulfur transferase activity
TSP02S_RS03775	COG1104	cysteine desulfurase activity
TSP02S_RS03780	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
TSP02S_RS03785	COG0719	Fe-S assembly protein
TSP02S_RS03795	COG4948	Mandelate Racemase Muconate Lactonizing
TSP02S_RS03810	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
TSP02S_RS03820	COG1247	-acetyltransferase
TSP02S_RS03825	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
TSP02S_RS03835	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
TSP02S_RS03870	COG0662	Cupin 2, conserved barrel domain protein
TSP02S_RS03870	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
TSP02S_RS03875	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
TSP02S_RS03880	COG1216	Glycosyl transferase, family 2
TSP02S_RS03945	COG1088	dTDP-glucose 4,6-dehydratase activity
TSP02S_RS03995	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
TSP02S_RS04010	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
TSP02S_RS04010	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
TSP02S_RS04035	COG1337	RAMP superfamily
TSP02S_RS04065	COG1337	RAMP superfamily
TSP02S_RS04120	COG1132	(ABC) transporter
TSP02S_RS04140	COG1653	transport
TSP02S_RS04145	COG1175	transmembrane transport
TSP02S_RS04150	COG0395	ABC-type sugar transport system, permease component
TSP02S_RS04155	COG0438	transferase activity, transferring glycosyl groups
TSP02S_RS04160	COG1940	carbohydrate kinase activity
TSP02S_RS04160	COG1846	Transcriptional regulator
TSP02S_RS04180	COG3842	ATPase activity
TSP02S_RS04190	COG0463	Glycosyl transferase, family 2
TSP02S_RS04200	COG0438	transferase activity, transferring glycosyl groups
TSP02S_RS04205	COG1677	Flagellar hook-basal body complex protein FliE
TSP02S_RS04210	COG1558	bacterial-type flagellum-dependent cell motility
TSP02S_RS04215	COG1815	bacterial-type flagellum-dependent cell motility
TSP02S_RS04230	COG4608	Belongs to the ABC transporter superfamily
TSP02S_RS04235	COG0444	Belongs to the ABC transporter superfamily
TSP02S_RS04245	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TSP02S_RS04250	COG0601	transmembrane transport
TSP02S_RS04255	COG0747	negative chemotaxis
TSP02S_RS04265	COG0306	phosphate transporter
TSP02S_RS04270	COG1392	Phosphate transport regulator
TSP02S_RS04275	COG3956	TIGRFAM MazG family protein
TSP02S_RS04280	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
TSP02S_RS04285	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
TSP02S_RS04300	COG1774	PSP1 C-terminal conserved region
TSP02S_RS04315	COG0571	ribonuclease III activity
TSP02S_RS04320	COG0635	Involved in the biosynthesis of porphyrin-containing compound
TSP02S_RS04325	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
TSP02S_RS04330	COG0072	phenylalanine-tRNA ligase activity
TSP02S_RS04330	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TSP02S_RS04340	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
TSP02S_RS04345	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
TSP02S_RS04350	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
TSP02S_RS04355	COG1028	Short-chain dehydrogenase reductase Sdr
TSP02S_RS04360	COG1737	Transcriptional regulator
TSP02S_RS04365	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
TSP02S_RS04380	COG2211	Major facilitator Superfamily
TSP02S_RS04385	COG1486	melibiose metabolic process
TSP02S_RS04400	COG0275	rRNA processing
TSP02S_RS04410	COG0768	penicillin binding
TSP02S_RS04420	COG0544	peptidyl-prolyl cis-trans isomerase activity
TSP02S_RS04425	COG0740	serine-type endopeptidase activity
TSP02S_RS04430	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
TSP02S_RS04440	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
TSP02S_RS04445	COG1573	uracil-dna glycosylase
TSP02S_RS04455	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
TSP02S_RS04460	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
TSP02S_RS04460	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
TSP02S_RS04470	COG1307	EDD domain protein, DegV family
TSP02S_RS04500	COG0492	ferredoxin-NADP+ reductase activity
TSP02S_RS04515	COG0330	HflC and HflK could
TSP02S_RS04525	COG1234	tRNA 3'-trailer cleavage
TSP02S_RS04530	COG0359	binds to the 23S rRNA
TSP02S_RS04535	COG0463	Glycosyl transferase, family 2
TSP02S_RS04540	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
TSP02S_RS04555	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
TSP02S_RS04560	COG4869	propanediol catabolic process
TSP02S_RS04570	COG1473	amidohydrolase
TSP02S_RS04585	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
TSP02S_RS04590	COG0575	Belongs to the CDS family
TSP02S_RS04595	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
TSP02S_RS04600	COG0233	cytoplasmic translational termination
TSP02S_RS04605	COG1131	(ABC) transporter
TSP02S_RS04620	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
TSP02S_RS04630	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
TSP02S_RS04640	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
TSP02S_RS04645	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
TSP02S_RS04650	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
TSP02S_RS04655	COG1420	regulation of RNA biosynthetic process
TSP02S_RS04660	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
TSP02S_RS04665	COG0484	heat shock protein binding
TSP02S_RS04675	COG1543	Belongs to the glycosyl hydrolase 57 family
TSP02S_RS04680	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
TSP02S_RS04685	COG1144	Oxidoreductase
TSP02S_RS04690	COG0674	pyruvate-flavodoxin oxidoreductase activity
TSP02S_RS04695	COG1013	pyruvate-flavodoxin oxidoreductase activity
TSP02S_RS04700	COG1335	isochorismatase
TSP02S_RS04715	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
TSP02S_RS04725	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
TSP02S_RS04730	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
TSP02S_RS04735	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
TSP02S_RS04740	COG3426	butyrate kinase activity
TSP02S_RS04745	COG0280	phosphate acetyltransferase
TSP02S_RS04750	COG3426	butyrate kinase activity
TSP02S_RS04780	COG1028	Short-chain dehydrogenase reductase Sdr
TSP02S_RS04785	COG1082	Xylose isomerase domain protein TIM barrel
TSP02S_RS04790	COG1234	tRNA 3'-trailer cleavage
TSP02S_RS04795	COG2211	Major facilitator Superfamily
TSP02S_RS04800	COG3842	ATPase activity
TSP02S_RS04820	COG1082	Xylose isomerase domain protein TIM barrel
TSP02S_RS04825	COG0561	phosphatase activity
TSP02S_RS04830	COG3842	ATPase activity
TSP02S_RS04840	COG1840	ABC-type Fe3 transport system, periplasmic component
TSP02S_RS04855	COG1172	Belongs to the binding-protein-dependent transport system permease family
TSP02S_RS04865	COG1402	creatininase
TSP02S_RS04870	COG0673	inositol 2-dehydrogenase activity
TSP02S_RS04875	COG1063	alcohol dehydrogenase
TSP02S_RS04880	COG1349	DNA-binding transcription factor activity
TSP02S_RS04890	COG1028	Short-chain dehydrogenase reductase Sdr
TSP02S_RS04895	COG3875	lactate racemase activity
TSP02S_RS04900	COG0205	6-phosphofructokinase activity
TSP02S_RS04925	COG0534	Mate efflux family protein
TSP02S_RS04950	COG1486	melibiose metabolic process
TSP02S_RS04965	COG0395	ABC-type sugar transport system, permease component
TSP02S_RS04970	COG1175	transmembrane transport
TSP02S_RS04995	COG1175	transmembrane transport
TSP02S_RS05000	COG0395	ABC-type sugar transport system, permease component
TSP02S_RS05005	COG0626	cystathionine gamma-synthase activity
TSP02S_RS05010	COG2186	Transcriptional regulator
TSP02S_RS05015	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
TSP02S_RS05020	COG1085	galactose-1-phosphate uridylyltransferase
TSP02S_RS05035	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
TSP02S_RS05040	COG2945	thiolester hydrolase activity
TSP02S_RS05040	COG0596	Alpha beta hydrolase
TSP02S_RS05045	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
TSP02S_RS05050	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
TSP02S_RS05080	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
TSP02S_RS05090	COG0454	-acetyltransferase
TSP02S_RS05125	COG1904	glucuronate isomerase
TSP02S_RS05135	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
TSP02S_RS05140	COG0295	cytidine deaminase activity
TSP02S_RS05150	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
TSP02S_RS05155	COG1228	amidohydrolase
TSP02S_RS05170	COG3842	ATPase activity
TSP02S_RS05195	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
TSP02S_RS05200	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TSP02S_RS05205	COG1120	ATPase activity
TSP02S_RS05225	COG1744	ABC transporter substrate-binding protein PnrA-like
TSP02S_RS05230	COG3845	ABC transporter
TSP02S_RS05235	COG4603	Belongs to the binding-protein-dependent transport system permease family
TSP02S_RS05240	COG1079	Belongs to the binding-protein-dependent transport system permease family
TSP02S_RS05250	COG0849	cell division
TSP02S_RS05255	COG1193	negative regulation of DNA recombination
TSP02S_RS05265	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
TSP02S_RS05270	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
TSP02S_RS05285	COG0187	DNA topoisomerase II activity
TSP02S_RS05295	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
TSP02S_RS05300	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TSP02S_RS05315	COG1132	(ABC) transporter
TSP02S_RS05325	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
TSP02S_RS05330	COG3290	protein histidine kinase activity
TSP02S_RS05330	COG3829	transcription factor binding
TSP02S_RS05340	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
TSP02S_RS05345	COG0427	acetyl-CoA hydrolase
TSP02S_RS05375	COG1028	Short-chain dehydrogenase reductase Sdr
TSP02S_RS05400	COG0596	Alpha beta hydrolase
TSP02S_RS05405	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
TSP02S_RS05410	COG2267	carboxylic ester hydrolase activity
TSP02S_RS05415	COG1324	tolerance protein
TSP02S_RS05420	COG0606	chelatase, subunit chli
TSP02S_RS05430	COG0012	GTP binding
TSP02S_RS05440	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
TSP02S_RS05440	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
TSP02S_RS05445	COG1765	OsmC-like protein
TSP02S_RS05450	COG0406	alpha-ribazole phosphatase activity
TSP02S_RS05455	COG4555	ABC transporter
TSP02S_RS05465	COG0395	ABC-type sugar transport system, permease component
TSP02S_RS05470	COG1175	transmembrane transport
TSP02S_RS05485	COG1472	Belongs to the glycosyl hydrolase 3 family
TSP02S_RS05490	COG1620	l-lactate permease
TSP02S_RS05495	COG1053	succinate dehydrogenase
TSP02S_RS05495	COG3976	FMN-binding domain protein
TSP02S_RS05520	COG0840	transmembrane signaling receptor activity
TSP02S_RS05525	COG1278	Cold shock
TSP02S_RS05535	COG1486	melibiose metabolic process
TSP02S_RS05545	COG0235	Class ii aldolase
TSP02S_RS05555	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
TSP02S_RS05575	COG0673	inositol 2-dehydrogenase activity
TSP02S_RS05580	COG0167	dihydroorotate dehydrogenase activity
TSP02S_RS05585	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
TSP02S_RS05595	COG1414	Transcriptional regulator
TSP02S_RS05600	COG1108	ABC-type Mn2 Zn2 transport systems permease components
TSP02S_RS05605	COG1121	(ABC) transporter
TSP02S_RS05610	COG0803	Belongs to the bacterial solute-binding protein 9 family
TSP02S_RS05620	COG0823	Involved in the tonB-independent uptake of proteins
TSP02S_RS05620	COG1506	peptidase
TSP02S_RS05620	COG4946	Tricorn protease homolog
TSP02S_RS05650	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
TSP02S_RS05655	COG4608	Belongs to the ABC transporter superfamily
TSP02S_RS05660	COG0444	Belongs to the ABC transporter superfamily
TSP02S_RS05670	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TSP02S_RS05675	COG0601	transmembrane transport
TSP02S_RS05680	COG0747	negative chemotaxis
TSP02S_RS05705	COG0303	'Molybdopterin
TSP02S_RS05710	COG0521	Mo-molybdopterin cofactor biosynthetic process
TSP02S_RS05725	COG4974	Belongs to the 'phage' integrase family
TSP02S_RS05730	COG1435	thymidine kinase activity
TSP02S_RS05735	COG4112	unkown
TSP02S_RS05740	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
TSP02S_RS05755	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
TSP02S_RS05765	COG1067	ATP-dependent peptidase activity
TSP02S_RS05770	COG1214	PFAM Peptidase M22, glycoprotease
TSP02S_RS05780	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
TSP02S_RS05815	COG1776	CheC inhibitor of MCP methylation
TSP02S_RS05815	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
TSP02S_RS05820	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
TSP02S_RS05830	COG1360	Flagellar Motor Protein
TSP02S_RS05840	COG1582	Flagellar protein (FlbD)
TSP02S_RS05850	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
TSP02S_RS05895	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
TSP02S_RS05940	COG1242	4 iron, 4 sulfur cluster binding
TSP02S_RS05945	COG0402	S-adenosylhomocysteine deaminase activity
TSP02S_RS05950	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
TSP02S_RS05955	COG0497	DNA recombination
TSP02S_RS05960	COG0210	DNA helicase
TSP02S_RS05970	COG0704	Plays a role in the regulation of phosphate uptake
TSP02S_RS05975	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
TSP02S_RS05985	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
TSP02S_RS05990	COG2255	four-way junction helicase activity
TSP02S_RS05995	COG0017	Asparaginyl-tRNA synthetase
TSP02S_RS06035	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
TSP02S_RS06040	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
TSP02S_RS06050	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
TSP02S_RS06050	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
TSP02S_RS06060	COG4608	Belongs to the ABC transporter superfamily
TSP02S_RS06065	COG0444	Belongs to the ABC transporter superfamily
TSP02S_RS06070	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TSP02S_RS06075	COG0601	transmembrane transport
TSP02S_RS06080	COG0747	negative chemotaxis
TSP02S_RS06095	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
TSP02S_RS06120	COG1175	transmembrane transport
TSP02S_RS06140	COG0254	rRNA binding
TSP02S_RS06145	COG1098	S1 RNA binding domain
TSP02S_RS06150	COG1376	ErfK ybiS ycfS ynhG family protein
TSP02S_RS06155	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
TSP02S_RS06160	COG1758	RNA polymerase activity
TSP02S_RS06165	COG0194	GDP metabolic process
TSP02S_RS06170	COG2052	Domain of unknown function (DUF370)
TSP02S_RS06185	COG2205	protein histidine kinase activity
TSP02S_RS06200	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
TSP02S_RS06200	COG0617	tRNA 3'-terminal CCA addition
TSP02S_RS06200	COG0517	IMP dehydrogenase activity
TSP02S_RS06210	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
TSP02S_RS06215	COG1469	GTP cyclohydrolase I activity
TSP02S_RS06220	COG0720	synthase
TSP02S_RS06225	COG0489	protein tyrosine kinase activity
TSP02S_RS06235	COG0628	permease
TSP02S_RS06245	COG0534	Mate efflux family protein
TSP02S_RS06255	COG1157	protein secretion by the type III secretion system
TSP02S_RS06265	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
TSP02S_RS06285	COG0333	Belongs to the bacterial ribosomal protein bL32 family
TSP02S_RS06290	COG0416	fatty acid biosynthetic process
TSP02S_RS06295	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
TSP02S_RS06300	COG0799	negative regulation of ribosome biogenesis
TSP02S_RS06305	COG0191	fructose-bisphosphate aldolase activity
TSP02S_RS06320	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
TSP02S_RS06330	COG4608	Belongs to the ABC transporter superfamily
TSP02S_RS06335	COG0444	Belongs to the ABC transporter superfamily
TSP02S_RS06340	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TSP02S_RS06345	COG0601	transmembrane transport
TSP02S_RS06350	COG0747	negative chemotaxis
TSP02S_RS06360	COG0747	negative chemotaxis
TSP02S_RS06365	COG0601	transmembrane transport
TSP02S_RS06370	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TSP02S_RS06375	COG0444	Belongs to the ABC transporter superfamily
TSP02S_RS06380	COG4608	Belongs to the ABC transporter superfamily
TSP02S_RS06390	COG1013	pyruvate-flavodoxin oxidoreductase activity
TSP02S_RS06395	COG0674	pyruvate-flavodoxin oxidoreductase activity
TSP02S_RS06395	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
TSP02S_RS06400	COG2033	superoxide reductase activity
TSP02S_RS06405	COG1592	Rubrerythrin
TSP02S_RS06410	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
TSP02S_RS06415	COG1940	carbohydrate kinase activity
TSP02S_RS06420	COG1653	transport
TSP02S_RS06430	COG0395	ABC-type sugar transport system, permease component
TSP02S_RS06460	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
TSP02S_RS06470	COG3250	beta-galactosidase activity
TSP02S_RS06495	COG0534	Mate efflux family protein
TSP02S_RS06505	COG1309	transcriptional regulator
TSP02S_RS06515	COG1131	(ABC) transporter
TSP02S_RS06540	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TSP02S_RS06545	COG0052	Belongs to the universal ribosomal protein uS2 family
TSP02S_RS06550	COG0572	uridine kinase
TSP02S_RS06560	COG0297	glycogen (starch) synthase activity
TSP02S_RS06570	COG2359	stage V sporulation protein S
TSP02S_RS06585	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
TSP02S_RS06590	COG1185	polyribonucleotide nucleotidyltransferase activity
TSP02S_RS06595	COG0612	Peptidase, M16
TSP02S_RS06600	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
TSP02S_RS06605	COG2116	formate transmembrane transporter activity
TSP02S_RS06615	COG0746	molybdenum cofactor guanylyltransferase activity
TSP02S_RS06620	COG3383	formate dehydrogenase (NAD+) activity
TSP02S_RS06630	COG1610	YqeY-like protein
TSP02S_RS06635	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
TSP02S_RS06640	COG0776	regulation of translation
TSP02S_RS06650	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
TSP02S_RS06650	COG0574	Belongs to the PEP-utilizing enzyme family
TSP02S_RS06655	COG2813	Specifically methylates the guanine in position
TSP02S_RS06660	COG1122	ATPase activity
TSP02S_RS06665	COG1122	ATPase activity
TSP02S_RS06670	COG1506	peptidase
TSP02S_RS06670	COG0823	Involved in the tonB-independent uptake of proteins
TSP02S_RS06670	COG4946	Tricorn protease homolog
TSP02S_RS06680	COG1187	pseudouridine synthase activity
TSP02S_RS06685	COG1079	Belongs to the binding-protein-dependent transport system permease family
TSP02S_RS06690	COG4603	Belongs to the binding-protein-dependent transport system permease family
TSP02S_RS06695	COG3845	ABC transporter
TSP02S_RS06700	COG1744	ABC transporter substrate-binding protein PnrA-like
TSP02S_RS06705	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
TSP02S_RS06715	COG0587	DNA-directed DNA polymerase activity
TSP02S_RS06720	COG0564	pseudouridine synthase activity
TSP02S_RS06725	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
TSP02S_RS06730	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
TSP02S_RS06740	COG0217	transcriptional regulatory protein
TSP02S_RS06745	COG2208	phosphoserine phosphatase activity
TSP02S_RS06750	COG0745	RESPONSE REGULATOR receiver
TSP02S_RS06760	COG1078	dGTPase activity
TSP02S_RS06770	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
TSP02S_RS06775	COG3872	metal-dependent enzyme
TSP02S_RS06780	COG5002	protein histidine kinase activity
TSP02S_RS06780	COG3850	Histidine kinase
TSP02S_RS06785	COG0745	RESPONSE REGULATOR receiver
TSP02S_RS06795	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
TSP02S_RS06800	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
TSP02S_RS06805	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
TSP02S_RS06810	COG0126	phosphoglycerate kinase activity
TSP02S_RS06815	COG0149	triose-phosphate isomerase activity
TSP02S_RS06815	COG0126	phosphoglycerate kinase activity
TSP02S_RS06820	COG2045	Belongs to the ComB family
TSP02S_RS06835	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TSP02S_RS06850	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
TSP02S_RS06865	COG5002	protein histidine kinase activity
TSP02S_RS06870	COG0745	RESPONSE REGULATOR receiver
TSP02S_RS06895	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
TSP02S_RS06905	COG1278	Cold shock
TSP02S_RS06910	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
TSP02S_RS06920	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
TSP02S_RS06925	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
TSP02S_RS06935	COG0018	arginyl-trna synthetase
TSP02S_RS06945	COG5001	Diguanylate cyclase
TSP02S_RS06950	COG0840	transmembrane signaling receptor activity
TSP02S_RS06955	COG0662	Cupin 2, conserved barrel domain protein
TSP02S_RS06960	COG2239	Acts as a magnesium transporter
TSP02S_RS06965	COG0009	L-threonylcarbamoyladenylate synthase
TSP02S_RS06985	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
TSP02S_RS06995	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
TSP02S_RS07005	COG0180	Tryptophanyl-tRNA synthetase
TSP02S_RS07010	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
TSP02S_RS07015	COG2759	Belongs to the formate--tetrahydrofolate ligase family
TSP02S_RS07020	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
TSP02S_RS07025	COG1302	Protein conserved in bacteria
TSP02S_RS07030	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
TSP02S_RS07035	COG0006	proline dipeptidase activity
TSP02S_RS07040	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
TSP02S_RS07045	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
TSP02S_RS07060	COG0737	Belongs to the 5'-nucleotidase family
TSP02S_RS07065	COG4658	electron transport chain
TSP02S_RS07095	COG0765	amino acid transport
TSP02S_RS07100	COG1126	abc transporter atp-binding protein
TSP02S_RS07105	COG0765	amino acid transport
TSP02S_RS07135	COG1175	transmembrane transport
TSP02S_RS07140	COG0395	ABC-type sugar transport system, permease component
TSP02S_RS07155	COG1175	transmembrane transport
TSP02S_RS07190	COG1175	transmembrane transport
TSP02S_RS07195	COG0395	ABC-type sugar transport system, permease component
TSP02S_RS07205	COG4608	Belongs to the ABC transporter superfamily
TSP02S_RS07215	COG0601	transmembrane transport
TSP02S_RS07220	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TSP02S_RS07225	COG0444	Belongs to the ABC transporter superfamily
TSP02S_RS07230	COG3534	alpha-L-arabinofuranosidase
TSP02S_RS07240	COG1070	Carbohydrate kinase
TSP02S_RS07245	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
TSP02S_RS07305	COG2391	methyltransferase activity
TSP02S_RS07310	COG0425	Belongs to the sulfur carrier protein TusA family
TSP02S_RS07320	COG0482	sulfurtransferase activity
TSP02S_RS07330	COG0154	amidase activity
TSP02S_RS07335	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
TSP02S_RS07345	COG0635	Involved in the biosynthesis of porphyrin-containing compound
TSP02S_RS07355	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
TSP02S_RS07365	COG0557	exoribonuclease II activity
TSP02S_RS07370	COG2267	carboxylic ester hydrolase activity
TSP02S_RS07375	COG0739	heme binding
TSP02S_RS07380	COG2201	protein-glutamate methylesterase activity
TSP02S_RS07395	COG1013	pyruvate-flavodoxin oxidoreductase activity
TSP02S_RS07410	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
TSP02S_RS07415	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
TSP02S_RS07430	COG1595	DNA-templated transcription, initiation
TSP02S_RS07445	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TSP02S_RS07450	COG0124	histidyl-tRNA synthetase
TSP02S_RS07455	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
TSP02S_RS07460	COG0215	cysteine-tRNA ligase activity
TSP02S_RS07465	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
TSP02S_RS07480	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
TSP02S_RS07495	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
TSP02S_RS07500	COG1811	Na channel or pump
TSP02S_RS07505	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
TSP02S_RS07515	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
TSP02S_RS07520	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
TSP02S_RS07545	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
TSP02S_RS07550	COG1923	regulation of RNA biosynthetic process
TSP02S_RS07555	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
TSP02S_RS07570	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
TSP02S_RS07575	COG0268	Binds directly to 16S ribosomal RNA
TSP02S_RS07585	COG0542	response to heat
TSP02S_RS07590	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
TSP02S_RS07595	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
TSP02S_RS07600	COG0230	Belongs to the bacterial ribosomal protein bL34 family
TSP02S_RS07605	COG0594	ribonuclease P activity
TSP02S_RS07610	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
TSP02S_RS07615	COG0706	membrane insertase activity
TSP02S_RS07630	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
TSP02S_RS07635	COG0683	leucine binding
TSP02S_RS07640	COG0559	Belongs to the binding-protein-dependent transport system permease family
TSP02S_RS07650	COG0411	ABC transporter
TSP02S_RS07660	COG1307	EDD domain protein, DegV family
TSP02S_RS07670	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
TSP02S_RS07675	COG0577	efflux transmembrane transporter activity
TSP02S_RS07675	COG1136	(ABC) transporter
TSP02S_RS07680	COG1136	(ABC) transporter
TSP02S_RS07685	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
TSP02S_RS07720	COG0528	UMP kinase activity
TSP02S_RS07725	COG0148	phosphopyruvate hydratase activity
TSP02S_RS07730	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
TSP02S_RS07755	COG0504	CTP synthase activity
TSP02S_RS07765	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
TSP02S_RS07785	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
TSP02S_RS07795	COG0138	bifunctional purine biosynthesis protein purh
TSP02S_RS07800	COG1040	competence protein
TSP02S_RS07805	COG0840	transmembrane signaling receptor activity
TSP02S_RS07810	COG0601	transmembrane transport
TSP02S_RS07815	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TSP02S_RS07820	COG0444	Belongs to the ABC transporter superfamily
TSP02S_RS07825	COG4608	Belongs to the ABC transporter superfamily
TSP02S_RS07835	COG0444	Belongs to the ABC transporter superfamily
TSP02S_RS07840	COG4608	Belongs to the ABC transporter superfamily
TSP02S_RS07845	COG0747	negative chemotaxis
TSP02S_RS07850	COG0601	transmembrane transport
TSP02S_RS07855	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TSP02S_RS07860	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
TSP02S_RS07865	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
TSP02S_RS07870	COG0772	Belongs to the SEDS family
TSP02S_RS07875	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
TSP02S_RS07880	COG0800	Aldolase
TSP02S_RS07900	COG1058	Belongs to the CinA family
TSP02S_RS07900	COG1546	Belongs to the CinA family
TSP02S_RS07905	COG0643	Histidine kinase
TSP02S_RS07905	COG2198	Histidine kinase
TSP02S_RS07910	COG0835	chemotaxis
TSP02S_RS07915	COG2201	protein-glutamate methylesterase activity
TSP02S_RS07925	COG1338	Plays a role in the flagellum-specific transport system
TSP02S_RS07930	COG1987	bacterial-type flagellum assembly
TSP02S_RS07935	COG1684	flagellar biosynthetic protein fliR
TSP02S_RS07940	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
TSP02S_RS07945	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
TSP02S_RS07950	COG1419	protein localization to endoplasmic reticulum
TSP02S_RS07955	COG0455	bacterial-type flagellum organization
TSP02S_RS07965	COG1776	CheC inhibitor of MCP methylation
TSP02S_RS07970	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
TSP02S_RS08000	COG0482	sulfurtransferase activity
TSP02S_RS08015	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
TSP02S_RS08020	COG0203	ribosomal protein L17
TSP02S_RS08025	COG0202	RNA polymerase activity
TSP02S_RS08030	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
TSP02S_RS08035	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
TSP02S_RS08040	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
TSP02S_RS08045	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
TSP02S_RS08050	COG0024	Methionine aminopeptidase
TSP02S_RS08055	COG0563	adenylate kinase activity
TSP02S_RS08060	COG0201	protein transport
TSP02S_RS08065	COG0200	Binds to the 23S rRNA
TSP02S_RS08070	COG1841	ribosomal large subunit assembly
TSP02S_RS08075	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
TSP02S_RS08080	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
TSP02S_RS08085	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
TSP02S_RS08090	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
TSP02S_RS08095	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
TSP02S_RS08100	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
TSP02S_RS08105	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
TSP02S_RS08110	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
TSP02S_RS08115	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
TSP02S_RS08120	COG0255	Belongs to the universal ribosomal protein uL29 family
TSP02S_RS08125	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
TSP02S_RS08130	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
TSP02S_RS08135	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
TSP02S_RS08140	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
TSP02S_RS08145	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
TSP02S_RS08150	COG0089	rRNA binding
TSP02S_RS08155	COG0088	Forms part of the polypeptide exit tunnel
TSP02S_RS08160	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
TSP02S_RS08165	COG0051	transcription antitermination factor activity, RNA binding
TSP02S_RS08170	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
TSP02S_RS08175	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
TSP02S_RS08180	COG0049	tRNA binding
TSP02S_RS08185	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
TSP02S_RS08190	COG1966	Carbon starvation protein
TSP02S_RS08195	COG3279	Response regulator of the LytR AlgR family
TSP02S_RS08205	COG1323	Belongs to the UPF0348 family
TSP02S_RS08215	COG0322	excinuclease ABC activity
TSP02S_RS08225	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
TSP02S_RS08225	COG1918	ferrous iron import across plasma membrane
TSP02S_RS08235	COG0306	phosphate transporter
TSP02S_RS08255	COG2515	1-aminocyclopropane-1-carboxylate deaminase
TSP02S_RS08300	COG1131	(ABC) transporter
TSP02S_RS08310	COG2052	Domain of unknown function (DUF370)
TSP02S_RS08315	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
TSP02S_RS08320	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
TSP02S_RS08325	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TSP02S_RS08340	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
TSP02S_RS08350	COG1739	Uncharacterized protein family UPF0029
TSP02S_RS08355	COG0812	UDP-N-acetylmuramate dehydrogenase activity
TSP02S_RS08360	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
TSP02S_RS08365	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
TSP02S_RS08370	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
TSP02S_RS08375	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TSP02S_RS08390	COG0517	IMP dehydrogenase activity
TSP02S_RS08400	COG0785	Cytochrome C biogenesis protein
TSP02S_RS08415	COG0436	Aminotransferase
TSP02S_RS08420	COG1132	(ABC) transporter
TSP02S_RS08435	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
TSP02S_RS08440	COG0758	DNA mediated transformation
TSP02S_RS08440	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
TSP02S_RS08445	COG1148	4fe-4S ferredoxin, iron-sulfur binding domain protein
TSP02S_RS08445	COG2878	Part of a membrane complex involved in electron transport
TSP02S_RS08450	COG4657	Part of a membrane complex involved in electron transport
TSP02S_RS08455	COG4660	Part of a membrane complex involved in electron transport
TSP02S_RS08460	COG4659	FMN binding
TSP02S_RS08465	COG4658	electron transport chain
TSP02S_RS08470	COG4656	Part of a membrane complex involved in electron transport
TSP02S_RS08475	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
TSP02S_RS08490	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
TSP02S_RS08500	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
TSP02S_RS08510	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
TSP02S_RS08520	COG0735	belongs to the Fur family
TSP02S_RS08525	COG0195	Participates in both transcription termination and antitermination
TSP02S_RS08530	COG0779	Required for maturation of 30S ribosomal subunits
TSP02S_RS08575	COG1175	transmembrane transport
TSP02S_RS08580	COG0395	ABC-type sugar transport system, permease component
TSP02S_RS08590	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
TSP02S_RS08605	COG3876	Protein conserved in bacteria
TSP02S_RS08610	COG0395	ABC-type sugar transport system, permease component
TSP02S_RS08615	COG1175	transmembrane transport
TSP02S_RS08630	COG3852	Histidine kinase
TSP02S_RS08635	COG2204	response regulator
TSP02S_RS08640	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
TSP02S_RS08650	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
TSP02S_RS08660	COG1706	bacterial-type flagellum-dependent cell motility
TSP02S_RS08665	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
TSP02S_RS08680	COG4786	Flagellar basal body rod
TSP02S_RS08695	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
TSP02S_RS08695	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
TSP02S_RS08700	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
TSP02S_RS08705	COG0505	Belongs to the CarA family
TSP02S_RS08710	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
TSP02S_RS08715	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
TSP02S_RS08720	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
TSP02S_RS08725	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
TSP02S_RS08730	COG0165	Argininosuccinate lyase
TSP02S_RS08735	COG0137	argininosuccinate synthase activity
TSP02S_RS08760	COG1785	Belongs to the alkaline phosphatase family
TSP02S_RS08765	COG1362	aminopeptidase activity
TSP02S_RS08795	COG2358	TRAP transporter, solute receptor (TAXI family
TSP02S_RS08800	COG2362	D-Aminopeptidase
TSP02S_RS08805	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
TSP02S_RS08810	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
TSP02S_RS08820	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
TSP02S_RS08835	COG0601	transmembrane transport
TSP02S_RS08840	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TSP02S_RS08845	COG0444	Belongs to the ABC transporter superfamily
TSP02S_RS08850	COG4608	Belongs to the ABC transporter superfamily
TSP02S_RS08855	COG0154	amidase activity
TSP02S_RS08860	COG4948	Mandelate Racemase Muconate Lactonizing
TSP02S_RS08875	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
TSP02S_RS08880	COG3842	ATPase activity
TSP02S_RS08885	COG1177	transmembrane transport
TSP02S_RS08890	COG1176	ABC-type spermidine putrescine transport system, permease component I
TSP02S_RS08895	COG1840	ABC-type Fe3 transport system, periplasmic component
TSP02S_RS08925	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
TSP02S_RS08980	COG1862	Preprotein translocase
TSP02S_RS08985	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
TSP02S_RS08990	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
TSP02S_RS09005	COG0584	glycerophosphoryl diester phosphodiesterase
TSP02S_RS09015	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TSP02S_RS09020	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
TSP02S_RS09025	COG0561	phosphatase activity
TSP02S_RS09035	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
TSP02S_RS09040	COG0305	Participates in initiation and elongation during chromosome replication
TSP02S_RS09065	COG2986	histidine ammonia-lyase
TSP02S_RS09080	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
TSP02S_RS09085	COG1660	Displays ATPase and GTPase activities
TSP02S_RS09090	COG0391	Required for morphogenesis under gluconeogenic growth conditions
TSP02S_RS09100	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
TSP02S_RS09105	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
TSP02S_RS09110	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
TSP02S_RS09125	COG0572	uridine kinase
TSP02S_RS09140	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
TSP02S_RS09145	COG0793	Belongs to the peptidase S41A family
TSP02S_RS09165	COG0438	transferase activity, transferring glycosyl groups
TSP02S_RS09175	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
TSP02S_RS09175	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
TSP02S_RS09180	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
TSP02S_RS09190	COG0697	spore germination
TSP02S_RS09195	COG2814	Major facilitator Superfamily
TSP02S_RS09205	COG2217	Heavy metal translocating P-type atpase
TSP02S_RS09210	COG0640	Transcriptional regulator
TSP02S_RS09215	COG0463	Glycosyl transferase, family 2
TSP02S_RS09230	COG0495	leucyl-tRNA aminoacylation
TSP02S_RS09235	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
TSP02S_RS09240	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
TSP02S_RS09245	COG1162	GTPase activity
TSP02S_RS09255	COG0820	rRNA (adenine-C2-)-methyltransferase activity
TSP02S_RS09260	COG0542	response to heat
TSP02S_RS09265	COG3864	Putative metallopeptidase domain
TSP02S_RS09280	COG1181	Belongs to the D-alanine--D-alanine ligase family
TSP02S_RS09305	COG2217	Heavy metal translocating P-type atpase
TSP02S_RS09315	COG2188	Transcriptional regulator
TSP02S_RS09325	COG4821	SIS domain
TSP02S_RS09340	COG1175	transmembrane transport
TSP02S_RS09345	COG0395	ABC-type sugar transport system, permease component
TSP02S_RS09360	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
TSP02S_RS09365	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
TSP02S_RS09375	COG0481	GTPase activity
TSP02S_RS09380	COG1082	Xylose isomerase domain protein TIM barrel
TSP02S_RS09385	COG1879	ABC-type sugar transport system periplasmic component
TSP02S_RS09390	COG1172	Belongs to the binding-protein-dependent transport system permease family
TSP02S_RS09395	COG1129	ABC transporter
TSP02S_RS09410	COG1609	Transcriptional regulator
TSP02S_RS09425	COG1172	Belongs to the binding-protein-dependent transport system permease family
TSP02S_RS09430	COG1129	ABC transporter
TSP02S_RS09435	COG1609	Transcriptional regulator
TSP02S_RS09445	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
TSP02S_RS09455	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
TSP02S_RS09460	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
TSP02S_RS09470	COG0402	S-adenosylhomocysteine deaminase activity
TSP02S_RS09480	COG0493	'glutamate synthase
TSP02S_RS09480	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
TSP02S_RS09485	COG0543	2 iron, 2 sulfur cluster binding
TSP02S_RS09500	COG0395	ABC-type sugar transport system, permease component
TSP02S_RS09515	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
TSP02S_RS09535	COG0772	Belongs to the SEDS family
TSP02S_RS09540	COG0037	tRNA processing
TSP02S_RS09550	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
TSP02S_RS09555	COG0420	3'-5' exonuclease activity
TSP02S_RS09560	COG0419	ATPase involved in DNA repair
TSP02S_RS09570	COG1228	amidohydrolase
TSP02S_RS09575	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
TSP02S_RS09580	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
TSP02S_RS09585	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
TSP02S_RS09585	COG3620	sequence-specific DNA binding
TSP02S_RS09585	COG0617	tRNA 3'-terminal CCA addition
TSP02S_RS09590	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
TSP02S_RS09595	COG0747	negative chemotaxis
TSP02S_RS09610	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
TSP02S_RS09620	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
TSP02S_RS09630	COG1653	transport
TSP02S_RS09640	COG0395	ABC-type sugar transport system, permease component
TSP02S_RS09645	COG0840	transmembrane signaling receptor activity
TSP02S_RS09655	COG0277	FAD linked oxidase domain protein
TSP02S_RS09660	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
TSP02S_RS09665	COG2086	electron transfer activity
TSP02S_RS09670	COG1472	Belongs to the glycosyl hydrolase 3 family
TSP02S_RS09675	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
TSP02S_RS09680	COG2188	Transcriptional regulator
TSP02S_RS09695	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TSP02S_RS09705	COG1850	ribulose-bisphosphate carboxylase activity
TSP02S_RS09710	COG3958	Transketolase
TSP02S_RS09715	COG3959	Transketolase, thiamine diphosphate binding domain
TSP02S_RS09720	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
TSP02S_RS09725	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
TSP02S_RS09730	COG4214	carbohydrate transport
TSP02S_RS09735	COG1129	ABC transporter
TSP02S_RS09750	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
TSP02S_RS09765	COG0604	alcohol dehydrogenase
TSP02S_RS09775	COG0237	dephospho-CoA kinase activity
TSP02S_RS09785	COG0166	Belongs to the GPI family
TSP02S_RS09790	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
TSP02S_RS09795	COG0227	Belongs to the bacterial ribosomal protein bL28 family
TSP02S_RS09800	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
TSP02S_RS09805	COG1181	Belongs to the D-alanine--D-alanine ligase family
TSP02S_RS09820	COG0494	nUDIX hydrolase
TSP02S_RS09825	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
TSP02S_RS09835	COG0488	(ABC) transporter
TSP02S_RS09855	COG5002	protein histidine kinase activity
TSP02S_RS09855	COG3850	Histidine kinase
TSP02S_RS09860	COG0745	RESPONSE REGULATOR receiver
TSP02S_RS09875	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
TSP02S_RS09880	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
TSP02S_RS09885	COG0284	orotidine-5'-phosphate decarboxylase activity
TSP02S_RS09890	COG0167	dihydroorotate dehydrogenase activity
TSP02S_RS09895	COG0543	2 iron, 2 sulfur cluster binding
TSP02S_RS09900	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
TSP02S_RS09905	COG0405	Gamma-glutamyltransferase
TSP02S_RS09925	COG3608	succinylglutamate desuccinylase aspartoacylase
TSP02S_RS09945	COG1132	(ABC) transporter
TSP02S_RS09960	COG0371	Dehydrogenase
TSP02S_RS09965	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
TSP02S_RS09965	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
TSP02S_RS09975	COG0312	modulator of DNA gyrase
TSP02S_RS09995	COG3290	protein histidine kinase activity
TSP02S_RS09995	COG0840	transmembrane signaling receptor activity
TSP02S_RS10000	COG3706	GGDEF domain
TSP02S_RS10005	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
TSP02S_RS10015	COG1175	transmembrane transport
TSP02S_RS10020	COG0395	ABC-type sugar transport system, permease component
TSP02S_RS10025	COG1940	carbohydrate kinase activity
TSP02S_RS10040	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
TSP02S_RS10045	COG0220	tRNA (guanine-N7-)-methyltransferase activity
TSP02S_RS10055	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
TSP02S_RS10055	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
TSP02S_RS10060	COG0741	lytic transglycosylase activity
TSP02S_RS10090	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
TSP02S_RS10100	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
TSP02S_RS10105	COG0443	Heat shock 70 kDa protein
TSP02S_RS10110	COG0071	Belongs to the small heat shock protein (HSP20) family
TSP02S_RS10115	COG0542	response to heat
TSP02S_RS10120	COG1609	Transcriptional regulator
TSP02S_RS10130	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
TSP02S_RS10135	COG1126	abc transporter atp-binding protein
TSP02S_RS10140	COG0765	amino acid transport
TSP02S_RS10145	COG0765	amino acid transport
TSP02S_RS10150	COG0436	Aminotransferase
TSP02S_RS10155	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
TSP02S_RS10160	COG4974	Belongs to the 'phage' integrase family
TSP02S_RS10170	COG0456	acetyltransferase
TSP02S_RS10170	COG1214	PFAM Peptidase M22, glycoprotease
TSP02S_RS10210	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
TSP02S_RS10215	COG0673	inositol 2-dehydrogenase activity
TSP02S_RS10220	COG3069	C4-dicarboxylate transmembrane transporter activity
TSP02S_RS10235	COG0446	pyridine nucleotide-disulphide oxidoreductase
TSP02S_RS10255	COG2358	TRAP transporter, solute receptor (TAXI family
TSP02S_RS10265	COG1921	L-seryl-tRNASec selenium transferase activity
TSP02S_RS10275	COG0251	oxidation-reduction process
TSP02S_RS10300	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
TSP02S_RS10310	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
TSP02S_RS10315	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
TSP02S_RS10320	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
TSP02S_RS10325	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
TSP02S_RS10350	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
TSP02S_RS10365	COG3263	regulation of cellular component size
TSP02S_RS10370	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
TSP02S_RS10395	COG2222	sugar isomerase
TSP02S_RS10405	COG4821	SIS domain
TSP02S_RS10420	COG1175	transmembrane transport
TSP02S_RS10425	COG0395	ABC-type sugar transport system, permease component
TSP02S_RS10450	COG1070	Carbohydrate kinase
TSP02S_RS10460	COG2390	Transcriptional regulator
TSP02S_RS10465	COG0395	ABC-type sugar transport system, permease component
TSP02S_RS10470	COG1175	transmembrane transport
TSP02S_RS10480	COG5002	protein histidine kinase activity
TSP02S_RS10485	COG0745	RESPONSE REGULATOR receiver
TSP02S_RS10505	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
TSP02S_RS10550	COG0411	ABC transporter
TSP02S_RS10570	COG0656	L-ascorbic acid biosynthetic process
TSP02S_RS10595	COG1418	mRNA catabolic process
TSP02S_RS10605	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
TSP02S_RS10610	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
TSP02S_RS10615	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
TSP02S_RS10620	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TSP02S_RS10635	COG1428	Deoxynucleoside kinase
TSP02S_RS10640	COG1428	Deoxynucleoside kinase
TSP02S_RS10645	COG0483	inositol monophosphate 1-phosphatase activity
TSP02S_RS10650	COG0556	nucleotide-excision repair
TSP02S_RS10660	COG1141	Ferredoxin
TSP02S_RS10685	COG3706	GGDEF domain
TSP02S_RS10695	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
TSP02S_RS10715	COG1132	(ABC) transporter
TSP02S_RS10730	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
TSP02S_RS10745	COG0741	lytic transglycosylase activity
TSP02S_RS10755	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
TSP02S_RS10760	COG0425	Belongs to the sulfur carrier protein TusA family
TSP02S_RS10765	COG2199	diguanylate cyclase activity
TSP02S_RS10765	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
TSP02S_RS10770	COG0395	ABC-type sugar transport system, permease component
TSP02S_RS10775	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
TSP02S_RS10795	COG0590	tRNA wobble adenosine to inosine editing
TSP02S_RS10800	COG3300	MHYT domain
TSP02S_RS10800	COG5001	Diguanylate cyclase
TSP02S_RS10810	COG3437	response regulator, receiver
TSP02S_RS10815	COG3437	response regulator, receiver
TSP02S_RS10815	COG0784	Response regulator, receiver