locus-tag	class	description
T2812B_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
T2812B_RS00010	COG0220	tRNA (guanine-N7-)-methyltransferase activity
T2812B_RS00025	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
T2812B_RS00025	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
T2812B_RS00045	COG0840	transmembrane signaling receptor activity
T2812B_RS00060	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
T2812B_RS00065	COG1392	Phosphate transport regulator
T2812B_RS00070	COG3956	TIGRFAM MazG family protein
T2812B_RS00080	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
T2812B_RS00085	COG1684	flagellar biosynthetic protein fliR
T2812B_RS00090	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
T2812B_RS00095	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
T2812B_RS00100	COG1419	protein localization to endoplasmic reticulum
T2812B_RS00105	COG0455	bacterial-type flagellum organization
T2812B_RS00115	COG1776	CheC inhibitor of MCP methylation
T2812B_RS00120	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
T2812B_RS00125	COG1191	sigma factor activity
T2812B_RS00150	COG2359	stage V sporulation protein S
T2812B_RS00155	COG1085	galactose-1-phosphate uridylyltransferase
T2812B_RS00160	COG0297	glycogen (starch) synthase activity
T2812B_RS00170	COG1968	undecaprenyl-diphosphatase activity
T2812B_RS00175	COG2239	Acts as a magnesium transporter
T2812B_RS00180	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
T2812B_RS00185	COG0750	zinc metalloprotease
T2812B_RS00190	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
T2812B_RS00200	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
T2812B_RS00205	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
T2812B_RS00220	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
T2812B_RS00225	COG2873	o-acetylhomoserine
T2812B_RS00230	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
T2812B_RS00235	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
T2812B_RS00245	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
T2812B_RS00245	COG0674	pyruvate-flavodoxin oxidoreductase activity
T2812B_RS00255	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
T2812B_RS00265	COG1214	PFAM Peptidase M22, glycoprotease
T2812B_RS00270	COG0542	response to heat
T2812B_RS00275	COG0275	rRNA processing
T2812B_RS00285	COG0768	penicillin binding
T2812B_RS00315	COG1234	tRNA 3'-trailer cleavage
T2812B_RS00320	COG0359	binds to the 23S rRNA
T2812B_RS00330	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
T2812B_RS00335	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
T2812B_RS00340	COG1862	Preprotein translocase
T2812B_RS00350	COG0196	riboflavin kinase activity
T2812B_RS00355	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
T2812B_RS00360	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
T2812B_RS00365	COG1639	'signal transduction protein
T2812B_RS00370	COG5002	protein histidine kinase activity
T2812B_RS00375	COG0009	L-threonylcarbamoyladenylate synthase
T2812B_RS00385	COG1420	regulation of RNA biosynthetic process
T2812B_RS00390	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
T2812B_RS00395	COG0484	heat shock protein binding
T2812B_RS00400	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
T2812B_RS00405	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
T2812B_RS00410	COG0295	cytidine deaminase activity
T2812B_RS00415	COG4535	Mg2 and Co2 transporter CorC
T2812B_RS00420	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
T2812B_RS00430	COG2201	protein-glutamate methylesterase activity
T2812B_RS00445	COG0772	Belongs to the SEDS family
T2812B_RS00455	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
T2812B_RS00460	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
T2812B_RS00465	COG0849	cell division
T2812B_RS00475	COG0187	DNA topoisomerase II activity
T2812B_RS00485	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
T2812B_RS00490	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
T2812B_RS00505	COG3842	ATPase activity
T2812B_RS00515	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
T2812B_RS00530	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
T2812B_RS00530	COG0072	phenylalanine-tRNA ligase activity
T2812B_RS00535	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
T2812B_RS00545	COG1979	alcohol dehydrogenase
T2812B_RS00555	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
T2812B_RS00575	COG0534	Mate efflux family protein
T2812B_RS00585	COG0426	domain, Protein
T2812B_RS00595	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
T2812B_RS00600	COG0395	ABC-type sugar transport system, permease component
T2812B_RS00620	COG1940	carbohydrate kinase activity
T2812B_RS00620	COG1846	Transcriptional regulator
T2812B_RS00625	COG0450	alkyl hydroperoxide reductase
T2812B_RS00635	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
T2812B_RS00640	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
T2812B_RS00645	COG0504	CTP synthase activity
T2812B_RS00650	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
T2812B_RS00655	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
T2812B_RS00660	COG2070	2-Nitropropane dioxygenase
T2812B_RS00665	COG1268	BioY protein
T2812B_RS00670	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
T2812B_RS00675	COG2045	Belongs to the ComB family
T2812B_RS00695	COG1131	(ABC) transporter
T2812B_RS00700	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
T2812B_RS00705	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
T2812B_RS00710	COG0351	phosphomethylpyrimidine kinase
T2812B_RS00710	COG1992	Thiamine-phosphate synthase
T2812B_RS00720	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
T2812B_RS00725	COG1635	Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur
T2812B_RS00795	COG1774	PSP1 C-terminal conserved region
T2812B_RS00805	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
T2812B_RS00810	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
T2812B_RS00815	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
T2812B_RS00820	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
T2812B_RS00830	COG1131	(ABC) transporter
T2812B_RS00840	COG0393	Putative heavy-metal-binding
T2812B_RS00845	COG0052	Belongs to the universal ribosomal protein uS2 family
T2812B_RS00860	COG1181	Belongs to the D-alanine--D-alanine ligase family
T2812B_RS00875	COG0457	Tetratricopeptide repeat
T2812B_RS00875	COG0463	Glycosyl transferase, family 2
T2812B_RS00880	COG1216	Glycosyl transferase, family 2
T2812B_RS00885	COG0426	domain, Protein
T2812B_RS00890	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
T2812B_RS00895	COG2226	methyltransferase
T2812B_RS00900	COG1486	melibiose metabolic process
T2812B_RS00905	COG3706	GGDEF domain
T2812B_RS00915	COG0572	uridine kinase
T2812B_RS00930	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
T2812B_RS00935	COG0793	Belongs to the peptidase S41A family
T2812B_RS00950	COG0438	transferase activity, transferring glycosyl groups
T2812B_RS00960	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
T2812B_RS00970	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
T2812B_RS00975	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
T2812B_RS00975	COG2199	diguanylate cyclase activity
T2812B_RS00990	COG1482	cell wall glycoprotein biosynthetic process
T2812B_RS01000	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
T2812B_RS01015	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
T2812B_RS01020	COG1490	D-aminoacyl-tRNA deacylase activity
T2812B_RS01025	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
T2812B_RS01040	COG0312	modulator of DNA gyrase
T2812B_RS01045	COG0312	modulator of DNA gyrase
T2812B_RS01065	COG0557	exoribonuclease II activity
T2812B_RS01070	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
T2812B_RS01075	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
T2812B_RS01080	COG0215	cysteine-tRNA ligase activity
T2812B_RS01085	COG0835	chemotaxis
T2812B_RS01090	COG0511	ligase activity, forming carbon-carbon bonds
T2812B_RS01100	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
T2812B_RS01105	COG0617	tRNA 3'-terminal CCA addition
T2812B_RS01105	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
T2812B_RS01105	COG3620	sequence-specific DNA binding
T2812B_RS01135	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
T2812B_RS01140	COG0095	Lipoate-protein ligase
T2812B_RS01145	COG0357	Ribosomal RNA small subunit methyltransferase G
T2812B_RS01155	COG1136	(ABC) transporter
T2812B_RS01160	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
T2812B_RS01165	COG1546	Belongs to the CinA family
T2812B_RS01165	COG1058	Belongs to the CinA family
T2812B_RS01170	COG2198	Histidine kinase
T2812B_RS01170	COG0643	Histidine kinase
T2812B_RS01175	COG0835	chemotaxis
T2812B_RS01180	COG2201	protein-glutamate methylesterase activity
T2812B_RS01190	COG1338	Plays a role in the flagellum-specific transport system
T2812B_RS01205	COG0740	serine-type endopeptidase activity
T2812B_RS01210	COG0544	peptidyl-prolyl cis-trans isomerase activity
T2812B_RS01220	COG0736	holo-[acyl-carrier-protein] synthase activity
T2812B_RS01235	COG0126	phosphoglycerate kinase activity
T2812B_RS01235	COG0149	triose-phosphate isomerase activity
T2812B_RS01240	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
T2812B_RS01245	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
T2812B_RS01250	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
T2812B_RS01280	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
T2812B_RS01280	COG1776	CheC inhibitor of MCP methylation
T2812B_RS01285	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
T2812B_RS01295	COG1360	Flagellar Motor Protein
T2812B_RS01305	COG1582	Flagellar protein (FlbD)
T2812B_RS01310	COG1749	Flagellar hook protein flgE
T2812B_RS01350	COG0084	hydrolase, TatD family'
T2812B_RS01360	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
T2812B_RS01375	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
T2812B_RS01385	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
T2812B_RS01395	COG2033	superoxide reductase activity
T2812B_RS01400	COG1592	Rubrerythrin
T2812B_RS01405	COG1476	TRANSCRIPTIONal
T2812B_RS01410	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
T2812B_RS01415	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
T2812B_RS01420	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
T2812B_RS01430	COG0561	phosphatase activity
T2812B_RS01445	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
T2812B_RS01450	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
T2812B_RS01480	COG1596	polysaccharide export
T2812B_RS01510	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
T2812B_RS01585	COG1091	dTDP-4-dehydrorhamnose reductase activity
T2812B_RS01600	COG0297	glycogen (starch) synthase activity
T2812B_RS01600	COG0438	transferase activity, transferring glycosyl groups
T2812B_RS01655	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
T2812B_RS01665	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
T2812B_RS01670	COG0629	single-stranded DNA binding
T2812B_RS01675	COG0360	Binds together with S18 to 16S ribosomal RNA
T2812B_RS01700	COG0395	ABC-type sugar transport system, permease component
T2812B_RS01705	COG1175	transmembrane transport
T2812B_RS01715	COG2252	PERMEase
T2812B_RS01720	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
T2812B_RS01725	COG0765	amino acid transport
T2812B_RS01735	COG0768	penicillin binding
T2812B_RS01750	COG1077	Cell shape determining protein MreB Mrl
T2812B_RS01755	COG0517	IMP dehydrogenase activity
T2812B_RS01755	COG1227	inorganic diphosphatase activity
T2812B_RS01760	COG0697	spore germination
T2812B_RS01765	COG0673	inositol 2-dehydrogenase activity
T2812B_RS01790	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
T2812B_RS01795	COG0037	tRNA processing
T2812B_RS01805	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
T2812B_RS01810	COG0456	acetyltransferase
T2812B_RS01815	COG2176	DNA-directed DNA polymerase activity
T2812B_RS01820	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
T2812B_RS01825	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
T2812B_RS01830	COG0815	Transfers the fatty acyl group on membrane lipoproteins
T2812B_RS01835	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
T2812B_RS01840	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
T2812B_RS01845	COG0552	protein localization to endoplasmic reticulum
T2812B_RS01860	COG1959	2 iron, 2 sulfur cluster binding
T2812B_RS01870	COG1489	DNA binding
T2812B_RS01895	COG1181	Belongs to the D-alanine--D-alanine ligase family
T2812B_RS01900	COG0598	Magnesium transport protein CorA
T2812B_RS01915	COG0505	Belongs to the CarA family
T2812B_RS01925	COG0473	3-isopropylmalate dehydrogenase activity
T2812B_RS01930	COG0066	3-isopropylmalate dehydratase activity
T2812B_RS01935	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
T2812B_RS01945	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
T2812B_RS01950	COG0129	dihydroxy-acid dehydratase activity
T2812B_RS01960	COG0440	acetolactate synthase activity
T2812B_RS01965	COG0028	Belongs to the TPP enzyme family
T2812B_RS01970	COG0527	aspartate kinase activity
T2812B_RS01975	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
T2812B_RS01980	COG0083	homoserine kinase activity
T2812B_RS01985	COG1131	(ABC) transporter
T2812B_RS02000	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
T2812B_RS02000	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
T2812B_RS02010	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
T2812B_RS02020	COG4717	serine-type aminopeptidase activity
T2812B_RS02035	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
T2812B_RS02040	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
T2812B_RS02045	COG0601	transmembrane transport
T2812B_RS02050	COG0747	negative chemotaxis
T2812B_RS02055	COG4608	Belongs to the ABC transporter superfamily
T2812B_RS02060	COG2608	mercury ion transmembrane transporter activity
T2812B_RS02065	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
T2812B_RS02070	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
T2812B_RS02075	COG1923	regulation of RNA biosynthetic process
T2812B_RS02080	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
T2812B_RS02100	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
T2812B_RS02105	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
T2812B_RS02110	COG0482	sulfurtransferase activity
T2812B_RS02140	COG1242	4 iron, 4 sulfur cluster binding
T2812B_RS02145	COG0442	prolyl-tRNA aminoacylation
T2812B_RS02150	COG0606	chelatase, subunit chli
T2812B_RS02160	COG1573	uracil-dna glycosylase
T2812B_RS02175	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
T2812B_RS02175	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
T2812B_RS02185	COG0459	protein refolding
T2812B_RS02190	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
T2812B_RS02195	COG0601	transmembrane transport
T2812B_RS02200	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
T2812B_RS02205	COG0444	Belongs to the ABC transporter superfamily
T2812B_RS02210	COG4608	Belongs to the ABC transporter superfamily
T2812B_RS02220	COG0444	Belongs to the ABC transporter superfamily
T2812B_RS02235	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
T2812B_RS02240	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
T2812B_RS02250	COG0180	Tryptophanyl-tRNA synthetase
T2812B_RS02260	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
T2812B_RS02270	COG2890	protein-(glutamine-N5) methyltransferase activity
T2812B_RS02275	COG2151	metal-sulfur cluster biosynthetic enzyme
T2812B_RS02285	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
T2812B_RS02290	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
T2812B_RS02295	COG1116	anion transmembrane transporter activity
T2812B_RS02325	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
T2812B_RS02330	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
T2812B_RS02335	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
T2812B_RS02340	COG1196	nuclear chromosome segregation
T2812B_RS02355	COG1335	isochorismatase
T2812B_RS02370	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
T2812B_RS02390	COG0745	RESPONSE REGULATOR receiver
T2812B_RS02400	COG0217	transcriptional regulatory protein
T2812B_RS02410	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
T2812B_RS02415	COG0564	pseudouridine synthase activity
T2812B_RS02420	COG0587	DNA-directed DNA polymerase activity
T2812B_RS02430	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
T2812B_RS02435	COG0085	RNA polymerase activity
T2812B_RS02440	COG0222	ribosome binding
T2812B_RS02445	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
T2812B_RS02450	COG0081	regulation of translation
T2812B_RS02460	COG0250	Participates in transcription elongation, termination and antitermination
T2812B_RS02465	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
T2812B_RS02475	COG0267	Belongs to the bacterial ribosomal protein bL33 family
T2812B_RS02500	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
T2812B_RS02505	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
T2812B_RS02510	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
T2812B_RS02515	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
T2812B_RS02520	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
T2812B_RS02525	COG1027	Aspartate ammonia-lyase
T2812B_RS02530	COG1070	Carbohydrate kinase
T2812B_RS02540	COG1028	Short-chain dehydrogenase reductase Sdr
T2812B_RS02550	COG1802	Transcriptional regulator
T2812B_RS02555	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
T2812B_RS02575	COG0747	negative chemotaxis
T2812B_RS02580	COG0601	transmembrane transport
T2812B_RS02585	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
T2812B_RS02590	COG0444	Belongs to the ABC transporter superfamily
T2812B_RS02595	COG4608	Belongs to the ABC transporter superfamily
T2812B_RS02605	COG0747	negative chemotaxis
T2812B_RS02610	COG1472	Belongs to the glycosyl hydrolase 3 family
T2812B_RS02620	COG3458	cephalosporin-C deacetylase activity
T2812B_RS02625	COG1486	melibiose metabolic process
T2812B_RS02630	COG3866	Pectate lyase
T2812B_RS02640	COG1175	transmembrane transport
T2812B_RS02645	COG0395	ABC-type sugar transport system, permease component
T2812B_RS02650	COG0840	transmembrane signaling receptor activity
T2812B_RS02655	COG1902	pentaerythritol trinitrate reductase activity
T2812B_RS02680	COG0371	Dehydrogenase
T2812B_RS02690	COG3842	ATPase activity
T2812B_RS02695	COG3833	ABC-type maltose transport systems, permease component
T2812B_RS02700	COG1175	transmembrane transport
T2812B_RS02710	COG1082	Xylose isomerase domain protein TIM barrel
T2812B_RS02720	COG0673	inositol 2-dehydrogenase activity
T2812B_RS02725	COG1402	creatininase
T2812B_RS02730	COG1063	alcohol dehydrogenase
T2812B_RS02745	COG0739	heme binding
T2812B_RS02750	COG2201	protein-glutamate methylesterase activity
T2812B_RS02765	COG1013	pyruvate-flavodoxin oxidoreductase activity
T2812B_RS02775	COG0347	Belongs to the P(II) protein family
T2812B_RS02780	COG0004	ammonium transporteR
T2812B_RS02785	COG1435	thymidine kinase activity
T2812B_RS02790	COG5002	protein histidine kinase activity
T2812B_RS02805	COG0067	glutamate synthase
T2812B_RS02815	COG0493	'glutamate synthase
T2812B_RS02815	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
T2812B_RS02835	COG0438	transferase activity, transferring glycosyl groups
T2812B_RS02840	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
T2812B_RS02845	COG0446	pyridine nucleotide-disulphide oxidoreductase
T2812B_RS02860	COG1194	a g-specific adenine glycosylase
T2812B_RS02865	COG0778	Nitroreductase
T2812B_RS02880	COG0778	Nitroreductase
T2812B_RS02895	COG1131	(ABC) transporter
T2812B_RS02900	COG0730	response to heat
T2812B_RS02905	COG4869	propanediol catabolic process
T2812B_RS02910	COG0071	Belongs to the small heat shock protein (HSP20) family
T2812B_RS02915	COG0443	Heat shock 70 kDa protein
T2812B_RS02925	COG1438	arginine binding
T2812B_RS02930	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
T2812B_RS02950	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
T2812B_RS02955	COG1362	aminopeptidase activity
T2812B_RS02960	COG0366	Alpha amylase catalytic
T2812B_RS02970	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
T2812B_RS02980	COG3956	TIGRFAM MazG family protein
T2812B_RS02985	COG0438	transferase activity, transferring glycosyl groups
T2812B_RS02990	COG1597	lipid kinase activity
T2812B_RS03005	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
T2812B_RS03020	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
T2812B_RS03025	COG1136	(ABC) transporter
T2812B_RS03030	COG0577	efflux transmembrane transporter activity
T2812B_RS03030	COG1136	(ABC) transporter
T2812B_RS03040	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
T2812B_RS03045	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
T2812B_RS03045	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
T2812B_RS03055	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
T2812B_RS03060	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
T2812B_RS03070	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
T2812B_RS03100	COG1032	radical SAM domain protein
T2812B_RS03105	COG1073	alpha beta
T2812B_RS03110	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
T2812B_RS03115	COG0543	2 iron, 2 sulfur cluster binding
T2812B_RS03120	COG0167	dihydroorotate dehydrogenase activity
T2812B_RS03125	COG0284	orotidine-5'-phosphate decarboxylase activity
T2812B_RS03130	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
T2812B_RS03135	COG1574	metal-dependent hydrolase with the TIM-barrel fold
T2812B_RS03155	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
T2812B_RS03160	COG1737	Transcriptional regulator
T2812B_RS03165	COG1028	Short-chain dehydrogenase reductase Sdr
T2812B_RS03170	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
T2812B_RS03180	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
T2812B_RS03200	COG2226	methyltransferase
T2812B_RS03205	COG2217	Heavy metal translocating P-type atpase
T2812B_RS03225	COG0667	Aldo Keto reductase
T2812B_RS03230	COG0673	inositol 2-dehydrogenase activity
T2812B_RS03245	COG0747	negative chemotaxis
T2812B_RS03250	COG1501	Belongs to the glycosyl hydrolase 31 family
T2812B_RS03270	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
T2812B_RS03275	COG1063	alcohol dehydrogenase
T2812B_RS03280	COG1028	Short-chain dehydrogenase reductase Sdr
T2812B_RS03290	COG0395	ABC-type sugar transport system, permease component
T2812B_RS03300	COG1653	transport
T2812B_RS03305	COG1063	alcohol dehydrogenase
T2812B_RS03315	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
T2812B_RS03320	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
T2812B_RS03325	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
T2812B_RS03330	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
T2812B_RS03340	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
T2812B_RS03340	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
T2812B_RS03340	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
T2812B_RS03350	COG1349	DNA-binding transcription factor activity
T2812B_RS03355	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
T2812B_RS03365	COG0066	3-isopropylmalate dehydratase activity
T2812B_RS03370	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
T2812B_RS03375	COG0372	Belongs to the citrate synthase family
T2812B_RS03380	COG0205	6-phosphofructokinase activity
T2812B_RS03385	COG1132	(ABC) transporter
T2812B_RS03390	COG1132	(ABC) transporter
T2812B_RS03400	COG0371	Dehydrogenase
T2812B_RS03410	COG0235	Class ii aldolase
T2812B_RS03415	COG1129	ABC transporter
T2812B_RS03420	COG1172	Belongs to the binding-protein-dependent transport system permease family
T2812B_RS03435	COG3534	alpha-L-arabinofuranosidase
T2812B_RS03445	COG0395	ABC-type sugar transport system, permease component
T2812B_RS03450	COG1175	transmembrane transport
T2812B_RS03465	COG0395	ABC-type sugar transport system, permease component
T2812B_RS03470	COG1175	transmembrane transport
T2812B_RS03480	COG2160	L-arabinose isomerase activity
T2812B_RS03490	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
T2812B_RS03495	COG0191	fructose-bisphosphate aldolase activity
T2812B_RS03500	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
T2812B_RS03500	COG0574	Belongs to the PEP-utilizing enzyme family
T2812B_RS03510	COG0646	methionine synthase
T2812B_RS03510	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
T2812B_RS03520	COG0646	methionine synthase
T2812B_RS03520	COG1410	methionine synthase
T2812B_RS03525	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
T2812B_RS03530	COG0776	regulation of translation
T2812B_RS03535	COG0322	excinuclease ABC activity
T2812B_RS03540	COG1187	pseudouridine synthase activity
T2812B_RS03545	COG0445	tRNA wobble uridine modification
T2812B_RS03550	COG0592	DNA-directed DNA polymerase activity
T2812B_RS03555	COG0306	phosphate transporter
T2812B_RS03570	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
T2812B_RS03575	COG3481	metal-dependent phosphohydrolase, HD sub domain
T2812B_RS03590	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
T2812B_RS03595	COG0792	nuclease activity
T2812B_RS03600	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
T2812B_RS03605	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
T2812B_RS03610	COG0758	DNA mediated transformation
T2812B_RS03615	COG1148	4fe-4S ferredoxin, iron-sulfur binding domain protein
T2812B_RS03615	COG2878	Part of a membrane complex involved in electron transport
T2812B_RS03625	COG4660	Part of a membrane complex involved in electron transport
T2812B_RS03635	COG4658	electron transport chain
T2812B_RS03640	COG4656	Part of a membrane complex involved in electron transport
T2812B_RS03645	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
T2812B_RS03665	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
T2812B_RS03675	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
T2812B_RS03680	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
T2812B_RS03685	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
T2812B_RS03695	COG0772	Belongs to the SEDS family
T2812B_RS03735	COG2515	1-aminocyclopropane-1-carboxylate deaminase
T2812B_RS03740	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
T2812B_RS03740	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
T2812B_RS03750	COG1122	ATPase activity
T2812B_RS03755	COG1766	The M ring may be actively involved in energy transduction
T2812B_RS03760	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
T2812B_RS03770	COG1157	protein secretion by the type III secretion system
T2812B_RS03780	COG0752	glycyl-tRNA synthetase alpha subunit
T2812B_RS03790	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
T2812B_RS03795	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
T2812B_RS03800	COG0509	glycine decarboxylation via glycine cleavage system
T2812B_RS03805	COG0404	The glycine cleavage system catalyzes the degradation of glycine
T2812B_RS03815	COG0205	6-phosphofructokinase activity
T2812B_RS03820	COG0469	pyruvate kinase activity
T2812B_RS03825	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
T2812B_RS03830	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
T2812B_RS03835	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
T2812B_RS03860	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
T2812B_RS03865	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
T2812B_RS03870	COG0542	response to heat
T2812B_RS03875	COG0037	tRNA processing
T2812B_RS03895	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
T2812B_RS03900	COG0390	transport system, permease component
T2812B_RS03925	COG2359	stage V sporulation protein S
T2812B_RS03930	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
T2812B_RS03935	COG4139	cobalamin transport
T2812B_RS03940	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
T2812B_RS03955	COG2205	protein histidine kinase activity
T2812B_RS03955	COG0784	Response regulator, receiver
T2812B_RS03970	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
T2812B_RS03980	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
T2812B_RS04025	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
T2812B_RS04030	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
T2812B_RS04040	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
T2812B_RS04045	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
T2812B_RS04050	COG1110	DNA topoisomerase II activity
T2812B_RS04055	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
T2812B_RS04060	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
T2812B_RS04070	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
T2812B_RS04075	COG0495	leucyl-tRNA aminoacylation
T2812B_RS04080	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
T2812B_RS04085	COG0285	dihydrofolate synthase activity
T2812B_RS04090	COG0632	four-way junction helicase activity
T2812B_RS04110	COG0142	geranyltranstransferase activity
T2812B_RS04120	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
T2812B_RS04125	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
T2812B_RS04140	COG1785	Belongs to the alkaline phosphatase family
T2812B_RS04165	COG0333	Belongs to the bacterial ribosomal protein bL32 family
T2812B_RS04170	COG0416	fatty acid biosynthetic process
T2812B_RS04175	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
T2812B_RS04180	COG0799	negative regulation of ribosome biogenesis
T2812B_RS04185	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
T2812B_RS04190	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
T2812B_RS04210	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
T2812B_RS04215	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
T2812B_RS04215	COG0512	Glutamine amidotransferase of anthranilate synthase
T2812B_RS04220	COG0134	indole-3-glycerol-phosphate synthase activity
T2812B_RS04225	COG0135	phosphoribosylanthranilate isomerase activity
T2812B_RS04230	COG0133	tryptophan synthase activity
T2812B_RS04235	COG0159	tryptophan synthase activity
T2812B_RS04240	COG0820	rRNA (adenine-C2-)-methyltransferase activity
T2812B_RS04250	COG0492	ferredoxin-NADP+ reductase activity
T2812B_RS04255	COG1335	isochorismatase
T2812B_RS04260	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
T2812B_RS04290	COG1108	ABC-type Mn2 Zn2 transport systems permease components
T2812B_RS04295	COG1121	(ABC) transporter
T2812B_RS04300	COG0803	Belongs to the bacterial solute-binding protein 9 family
T2812B_RS04310	COG1509	lysine 2,3-aminomutase activity
T2812B_RS04315	COG0778	Nitroreductase
T2812B_RS04335	COG1070	Carbohydrate kinase
T2812B_RS04340	COG1129	ABC transporter
T2812B_RS04355	COG1172	Belongs to the binding-protein-dependent transport system permease family
T2812B_RS04365	COG1940	carbohydrate kinase activity
T2812B_RS04375	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
T2812B_RS04390	COG1079	Belongs to the binding-protein-dependent transport system permease family
T2812B_RS04395	COG4603	Belongs to the binding-protein-dependent transport system permease family
T2812B_RS04400	COG3845	ABC transporter
T2812B_RS04405	COG1744	ABC transporter substrate-binding protein PnrA-like
T2812B_RS04415	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
T2812B_RS04425	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
T2812B_RS04430	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
T2812B_RS04435	COG3116	cell division
T2812B_RS04435	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
T2812B_RS04440	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
T2812B_RS04445	COG1459	type II secretion system
T2812B_RS04480	COG1355	regulation of microtubule-based process
T2812B_RS04485	COG0728	peptidoglycan biosynthetic process
T2812B_RS04505	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
T2812B_RS04510	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
T2812B_RS04515	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
T2812B_RS04520	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
T2812B_RS04525	COG1120	ATPase activity
T2812B_RS04535	COG1472	Belongs to the glycosyl hydrolase 3 family
T2812B_RS04545	COG0444	Belongs to the ABC transporter superfamily
T2812B_RS04550	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
T2812B_RS04555	COG0601	transmembrane transport
T2812B_RS04570	COG1312	Catalyzes the dehydration of D-mannonate
T2812B_RS04575	COG0246	Mannitol dehydrogenase
T2812B_RS04585	COG0800	Aldolase
T2812B_RS04590	COG1414	Transcriptional regulator
T2812B_RS04595	COG1904	glucuronate isomerase
T2812B_RS04610	COG3693	PFAM glycoside hydrolase, family 10
T2812B_RS04615	COG0601	transmembrane transport
T2812B_RS04620	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
T2812B_RS04625	COG0444	Belongs to the ABC transporter superfamily
T2812B_RS04630	COG4608	Belongs to the ABC transporter superfamily
T2812B_RS04635	COG0747	negative chemotaxis
T2812B_RS04640	COG3661	Belongs to the glycosyl hydrolase 67 family
T2812B_RS04660	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
T2812B_RS04660	COG1918	ferrous iron import across plasma membrane
T2812B_RS04670	COG2006	4fe-4S ferredoxin, iron-sulfur binding domain protein
T2812B_RS04685	COG1132	(ABC) transporter
T2812B_RS04690	COG0006	proline dipeptidase activity
T2812B_RS04695	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
T2812B_RS04695	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
T2812B_RS04700	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
T2812B_RS04710	COG0720	synthase
T2812B_RS04720	COG1618	nucleotide phosphatase activity, acting on free nucleotides
T2812B_RS04745	COG4166	transmembrane transport
T2812B_RS04750	COG0601	transmembrane transport
T2812B_RS04760	COG0444	Belongs to the ABC transporter superfamily
T2812B_RS04765	COG4608	Belongs to the ABC transporter superfamily
T2812B_RS04775	COG1472	Belongs to the glycosyl hydrolase 3 family
T2812B_RS04785	COG0840	transmembrane signaling receptor activity
T2812B_RS04790	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
T2812B_RS04795	COG1993	acr, cog1993
T2812B_RS04800	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
T2812B_RS04805	COG1028	Short-chain dehydrogenase reductase Sdr
T2812B_RS04810	COG1013	pyruvate-flavodoxin oxidoreductase activity
T2812B_RS04815	COG0674	pyruvate-flavodoxin oxidoreductase activity
T2812B_RS04820	COG1144	Oxidoreductase
T2812B_RS04825	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
T2812B_RS04870	COG4948	Mandelate Racemase Muconate Lactonizing
T2812B_RS04890	COG0737	Belongs to the 5'-nucleotidase family
T2812B_RS04900	COG0622	Phosphoesterase
T2812B_RS04910	COG1278	Cold shock
T2812B_RS04920	COG0432	Pfam Uncharacterised protein family UPF0047
T2812B_RS04930	COG2894	cell division
T2812B_RS04935	COG1067	ATP-dependent peptidase activity
T2812B_RS04940	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
T2812B_RS04955	COG1515	deoxyribonuclease V activity
T2812B_RS04980	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
T2812B_RS04985	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
T2812B_RS05000	COG1418	mRNA catabolic process
T2812B_RS05015	COG1175	transmembrane transport
T2812B_RS05020	COG0395	ABC-type sugar transport system, permease component
T2812B_RS05045	COG3459	Glycosyltransferase 36 associated
T2812B_RS05050	COG2723	6-phospho-beta-galactosidase activity
T2812B_RS05055	COG1653	transport
T2812B_RS05070	COG1940	carbohydrate kinase activity
T2812B_RS05080	COG1523	belongs to the glycosyl hydrolase 13 family
T2812B_RS05100	COG2182	Extracellular solute-binding protein
T2812B_RS05110	COG3833	ABC-type maltose transport systems, permease component
T2812B_RS05115	COG0366	Alpha amylase catalytic
T2812B_RS05120	COG1486	melibiose metabolic process
T2812B_RS05125	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
T2812B_RS05140	COG3706	GGDEF domain
T2812B_RS05145	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
T2812B_RS05145	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
T2812B_RS05150	COG0307	riboflavin synthase, alpha
T2812B_RS05155	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
T2812B_RS05155	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
T2812B_RS05170	COG0330	HflC and HflK could
T2812B_RS05175	COG0330	HflC and HflK could
T2812B_RS05180	COG1059	Responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine 7-oxoG) from DNA. Also nicks DNA at apurinic apyrimidinic sites (AP sites)
T2812B_RS05185	COG0519	Catalyzes the synthesis of GMP from XMP
T2812B_RS05185	COG0518	GMP synthase (glutamine-hydrolyzing) activity
T2812B_RS05195	COG2059	Chromate
T2812B_RS05200	COG0525	valine-tRNA ligase activity
T2812B_RS05225	COG1353	crispr-associated protein
T2812B_RS05235	COG1337	RAMP superfamily
T2812B_RS05270	COG0484	heat shock protein binding
T2812B_RS05300	COG1518	maintenance of DNA repeat elements
T2812B_RS05305	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
T2812B_RS05330	COG3337	CRISPR-associated protein (Cas_Cmr5)
T2812B_RS05375	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
T2812B_RS05380	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
T2812B_RS05385	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
T2812B_RS05390	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
T2812B_RS05395	COG0165	Argininosuccinate lyase
T2812B_RS05400	COG0137	argininosuccinate synthase activity
T2812B_RS05415	COG0195	Participates in both transcription termination and antitermination
T2812B_RS05420	COG0735	belongs to the Fur family
T2812B_RS05430	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
T2812B_RS05450	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
T2812B_RS05455	COG1722	exodeoxyribonuclease VII activity
T2812B_RS05460	COG1570	exodeoxyribonuclease VII activity
T2812B_RS05465	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
T2812B_RS05470	COG2759	Belongs to the formate--tetrahydrofolate ligase family
T2812B_RS05475	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
T2812B_RS05485	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
T2812B_RS05490	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
T2812B_RS05495	COG0556	nucleotide-excision repair
T2812B_RS05530	COG3426	butyrate kinase activity
T2812B_RS05535	COG0280	phosphate acetyltransferase
T2812B_RS05540	COG3426	butyrate kinase activity
T2812B_RS05550	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
T2812B_RS05560	COG0667	Aldo Keto reductase
T2812B_RS05565	COG0647	UMP catabolic process
T2812B_RS05570	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
T2812B_RS05575	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
T2812B_RS05590	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
T2812B_RS05595	COG0305	Participates in initiation and elongation during chromosome replication
T2812B_RS05605	COG0704	Plays a role in the regulation of phosphate uptake
T2812B_RS05610	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
T2812B_RS05620	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
T2812B_RS05625	COG2255	four-way junction helicase activity
T2812B_RS05650	COG1394	ATPase activity, coupled to movement of substances
T2812B_RS05655	COG1028	Short-chain dehydrogenase reductase Sdr
T2812B_RS05680	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
T2812B_RS05685	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
T2812B_RS05690	COG1162	GTPase activity
T2812B_RS05700	COG0820	rRNA (adenine-C2-)-methyltransferase activity
T2812B_RS05710	COG1739	Uncharacterized protein family UPF0029
T2812B_RS05730	COG0391	Required for morphogenesis under gluconeogenic growth conditions
T2812B_RS05740	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
T2812B_RS05745	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
T2812B_RS05750	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
T2812B_RS05760	COG1368	sulfuric ester hydrolase activity
T2812B_RS05770	COG0534	Mate efflux family protein
T2812B_RS05785	COG0436	Aminotransferase
T2812B_RS05805	COG0301	tRNA thio-modification
T2812B_RS05825	COG2052	Domain of unknown function (DUF370)
T2812B_RS05830	COG0194	GDP metabolic process
T2812B_RS05835	COG1758	RNA polymerase activity
T2812B_RS05840	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
T2812B_RS05845	COG1376	ErfK ybiS ycfS ynhG family protein
T2812B_RS05850	COG1185	polyribonucleotide nucleotidyltransferase activity
T2812B_RS05860	COG1278	Cold shock
T2812B_RS05905	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
T2812B_RS05935	COG2115	Belongs to the xylose isomerase family
T2812B_RS05940	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
T2812B_RS05950	COG2813	Specifically methylates the guanine in position
T2812B_RS05955	COG1122	ATPase activity
T2812B_RS05980	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
T2812B_RS05995	COG0745	RESPONSE REGULATOR receiver
T2812B_RS06000	COG5002	protein histidine kinase activity
T2812B_RS06015	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
T2812B_RS06030	COG1713	HD superfamily hydrolase involved in NAD metabolism
T2812B_RS06045	COG0157	Belongs to the NadC ModD family
T2812B_RS06050	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
T2812B_RS06055	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
T2812B_RS06090	COG1959	2 iron, 2 sulfur cluster binding
T2812B_RS06095	COG1575	Belongs to the MenA family. Type 1 subfamily
T2812B_RS06105	COG2086	electron transfer activity
T2812B_RS06110	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
T2812B_RS06115	COG0644	oxidoreductase
T2812B_RS06140	COG1032	radical SAM domain protein
T2812B_RS06150	COG1706	bacterial-type flagellum-dependent cell motility
T2812B_RS06155	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
T2812B_RS06170	COG4786	Flagellar basal body rod
T2812B_RS06190	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
T2812B_RS06190	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
T2812B_RS06195	COG1078	dGTPase activity
T2812B_RS06200	COG1086	Polysaccharide biosynthesis protein
T2812B_RS06205	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
T2812B_RS06210	COG3872	metal-dependent enzyme
T2812B_RS06215	COG2078	PFAM AMMECR1 domain protein
T2812B_RS06225	COG1477	protein flavinylation
T2812B_RS06245	COG2003	Belongs to the UPF0758 family
T2812B_RS06255	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
T2812B_RS06280	COG1254	Belongs to the acylphosphatase family
T2812B_RS06285	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
T2812B_RS06290	COG0228	four-way junction DNA binding
T2812B_RS06295	COG1837	Belongs to the UPF0109 family
T2812B_RS06300	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
T2812B_RS06305	COG0336	Belongs to the RNA methyltransferase TrmD family
T2812B_RS06310	COG4752	Belongs to the RNA methyltransferase TrmD family
T2812B_RS06315	COG0335	large ribosomal subunit rRNA binding
T2812B_RS06320	COG0681	Belongs to the peptidase S26 family
T2812B_RS06340	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
T2812B_RS06350	COG0653	protein targeting
T2812B_RS06380	COG1040	competence protein
T2812B_RS06385	COG2379	hydroxypyruvate reductase
T2812B_RS06400	COG2199	diguanylate cyclase activity
T2812B_RS06400	COG2203	Gaf domain
T2812B_RS06435	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
T2812B_RS06450	COG0489	protein tyrosine kinase activity
T2812B_RS06460	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
T2812B_RS06465	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
T2812B_RS06475	COG1595	DNA-templated transcription, initiation
T2812B_RS06490	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
T2812B_RS06495	COG1827	regulation of RNA biosynthetic process
T2812B_RS06500	COG0477	Major facilitator Superfamily
T2812B_RS06505	COG0528	UMP kinase activity
T2812B_RS06515	COG1530	ribonuclease E activity
T2812B_RS06520	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
T2812B_RS06525	COG1307	EDD domain protein, DegV family
T2812B_RS06530	COG0355	proton-transporting ATP synthase activity, rotational mechanism
T2812B_RS06535	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
T2812B_RS06540	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
T2812B_RS06545	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
T2812B_RS06550	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
T2812B_RS06555	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
T2812B_RS06560	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
T2812B_RS06565	COG0356	it plays a direct role in the translocation of protons across the membrane
T2812B_RS06580	COG1406	Chemotaxis phosphatase CheX
T2812B_RS06585	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
T2812B_RS06585	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
T2812B_RS06595	COG0584	glycerophosphoryl diester phosphodiesterase
T2812B_RS06605	COG0481	GTPase activity
T2812B_RS06610	COG3250	beta-galactosidase activity
T2812B_RS06625	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
T2812B_RS06630	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
T2812B_RS06635	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
T2812B_RS06650	COG0802	atpase or kinase
T2812B_RS06655	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
T2812B_RS06665	COG0420	3'-5' exonuclease activity
T2812B_RS06670	COG0419	ATPase involved in DNA repair
T2812B_RS06680	COG1131	(ABC) transporter
T2812B_RS06685	COG0543	2 iron, 2 sulfur cluster binding
T2812B_RS06690	COG0493	'glutamate synthase
T2812B_RS06695	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
T2812B_RS06700	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
T2812B_RS06700	COG0540	Belongs to the ATCase OTCase family
T2812B_RS06710	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
T2812B_RS06720	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
T2812B_RS06725	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
T2812B_RS06740	COG0019	diaminopimelate decarboxylase activity
T2812B_RS06745	COG1473	amidohydrolase
T2812B_RS06760	COG1323	Belongs to the UPF0348 family
T2812B_RS06765	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
T2812B_RS06765	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
T2812B_RS06770	COG2738	Putative neutral zinc metallopeptidase
T2812B_RS06780	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
T2812B_RS06785	COG1480	7TM receptor with intracellular HD hydrolase
T2812B_RS06790	COG1702	phosphate starvation-inducible protein PhoH
T2812B_RS06800	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
T2812B_RS06805	COG0049	tRNA binding
T2812B_RS06810	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
T2812B_RS06815	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
T2812B_RS06820	COG0051	transcription antitermination factor activity, RNA binding
T2812B_RS06825	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
T2812B_RS06830	COG0088	Forms part of the polypeptide exit tunnel
T2812B_RS06835	COG0089	rRNA binding
T2812B_RS06840	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
T2812B_RS06845	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
T2812B_RS06850	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
T2812B_RS06855	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
T2812B_RS06860	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
T2812B_RS06865	COG0255	Belongs to the universal ribosomal protein uL29 family
T2812B_RS06870	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
T2812B_RS06875	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
T2812B_RS06880	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
T2812B_RS06890	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
T2812B_RS06895	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
T2812B_RS06900	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
T2812B_RS06905	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
T2812B_RS06910	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
T2812B_RS06915	COG1841	ribosomal large subunit assembly
T2812B_RS06920	COG0200	Binds to the 23S rRNA
T2812B_RS06925	COG0201	protein transport
T2812B_RS06930	COG0563	adenylate kinase activity
T2812B_RS06940	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
T2812B_RS06945	COG0257	Belongs to the bacterial ribosomal protein bL36 family
T2812B_RS06950	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
T2812B_RS06955	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
T2812B_RS06960	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
T2812B_RS06965	COG0202	RNA polymerase activity
T2812B_RS06970	COG0203	ribosomal protein L17
T2812B_RS06975	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
T2812B_RS06985	COG1307	EDD domain protein, DegV family
T2812B_RS06995	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
T2812B_RS07005	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
T2812B_RS07015	COG0230	Belongs to the bacterial ribosomal protein bL34 family
T2812B_RS07025	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
T2812B_RS07030	COG0706	membrane insertase activity
T2812B_RS07055	COG0211	Belongs to the bacterial ribosomal protein bL27 family
T2812B_RS07060	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
T2812B_RS07065	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
T2812B_RS07070	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
T2812B_RS07075	COG0358	DNA primase activity
T2812B_RS07080	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
T2812B_RS07085	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
T2812B_RS07100	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
T2812B_RS07105	COG1160	GTP binding
T2812B_RS07115	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
T2812B_RS07120	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
T2812B_RS07125	COG1366	Belongs to the anti-sigma-factor antagonist family
T2812B_RS07130	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
T2812B_RS07135	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
T2812B_RS07135	COG2050	protein possibly involved in aromatic compounds catabolism
T2812B_RS07145	COG1543	Belongs to the glycosyl hydrolase 57 family
T2812B_RS07150	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
T2812B_RS07180	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
T2812B_RS07190	COG0840	transmembrane signaling receptor activity
T2812B_RS07195	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
T2812B_RS07210	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
T2812B_RS07225	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
T2812B_RS07240	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
T2812B_RS07240	COG1213	nucleotidyl transferase
T2812B_RS07245	COG0396	ATPase activity
T2812B_RS07250	COG0719	Fe-S assembly protein
T2812B_RS07260	COG0483	inositol monophosphate 1-phosphatase activity
T2812B_RS07265	COG1621	beta-fructofuranosidase activity
T2812B_RS07290	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
T2812B_RS07295	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
T2812B_RS07305	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
T2812B_RS07310	COG0575	Belongs to the CDS family
T2812B_RS07315	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
T2812B_RS07325	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
T2812B_RS07330	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
T2812B_RS07340	COG0542	response to heat
T2812B_RS07360	COG2264	protein methyltransferase activity
T2812B_RS07365	COG0742	ribosomal rna small subunit methyltransferase
T2812B_RS07370	COG0237	dephospho-CoA kinase activity
T2812B_RS07380	COG0166	Belongs to the GPI family
T2812B_RS07385	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
T2812B_RS07410	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
T2812B_RS07415	COG1177	transmembrane transport
T2812B_RS07420	COG1176	ABC-type spermidine putrescine transport system, permease component I
T2812B_RS07425	COG3842	ATPase activity
T2812B_RS07430	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
T2812B_RS07440	COG0406	alpha-ribazole phosphatase activity
T2812B_RS07450	COG0822	iron-sulfur transferase activity
T2812B_RS07455	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
T2812B_RS07460	COG1372	Participates in initiation and elongation during chromosome replication
T2812B_RS07460	COG0719	Fe-S assembly protein
T2812B_RS07465	COG0719	Fe-S assembly protein
T2812B_RS07470	COG0396	ATPase activity
T2812B_RS07485	COG1677	Flagellar hook-basal body complex protein FliE
T2812B_RS07495	COG1815	bacterial-type flagellum-dependent cell motility
T2812B_RS07500	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
T2812B_RS07510	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
T2812B_RS07515	COG0745	RESPONSE REGULATOR receiver
T2812B_RS07520	COG3852	Histidine kinase
T2812B_RS07545	COG0516	GMP reductase activity
T2812B_RS07545	COG0517	IMP dehydrogenase activity
T2812B_RS07560	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
T2812B_RS07565	COG2267	carboxylic ester hydrolase activity
T2812B_RS07570	COG0628	permease
T2812B_RS07580	COG0517	IMP dehydrogenase activity
T2812B_RS07580	COG0516	GMP reductase activity
T2812B_RS07585	COG0612	Peptidase, M16
T2812B_RS07595	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
T2812B_RS07625	COG0667	Aldo Keto reductase
T2812B_RS07640	COG0395	ABC-type sugar transport system, permease component
T2812B_RS07665	COG1132	(ABC) transporter
T2812B_RS07670	COG1132	(ABC) transporter
T2812B_RS07675	COG4555	ABC transporter
T2812B_RS07705	COG1598	PFAM Uncharacterised protein family UPF0150
T2812B_RS07720	COG1132	(ABC) transporter
T2812B_RS07755	COG4555	ABC transporter
T2812B_RS07765	COG0154	amidase activity
T2812B_RS07770	COG0667	Aldo Keto reductase
T2812B_RS07785	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
T2812B_RS07800	COG0662	Cupin 2, conserved barrel domain protein
T2812B_RS07810	COG1486	melibiose metabolic process
T2812B_RS07825	COG1193	negative regulation of DNA recombination
T2812B_RS07835	COG3842	ATPase activity
T2812B_RS07850	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
T2812B_RS07855	COG0154	amidase activity
T2812B_RS07860	COG2165	general secretion pathway protein
T2812B_RS07865	COG0626	cystathionine gamma-synthase activity
T2812B_RS07870	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
T2812B_RS07895	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
T2812B_RS07910	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
T2812B_RS07915	COG0704	Plays a role in the regulation of phosphate uptake
T2812B_RS07920	COG0745	RESPONSE REGULATOR receiver
T2812B_RS07935	COG1132	(ABC) transporter
T2812B_RS07940	COG0436	Aminotransferase
T2812B_RS07945	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
T2812B_RS07950	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
T2812B_RS07950	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
T2812B_RS07960	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
T2812B_RS07965	COG0151	Belongs to the GarS family
T2812B_RS07970	COG0138	bifunctional purine biosynthesis protein purh
T2812B_RS07975	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
T2812B_RS07980	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
T2812B_RS07985	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
T2812B_RS07990	COG0047	phosphoribosylformylglycinamidine synthase activity
T2812B_RS07995	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
T2812B_RS08000	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
T2812B_RS08015	COG0012	GTP binding
T2812B_RS08025	COG0210	DNA helicase
T2812B_RS08050	COG3842	ATPase activity
T2812B_RS08060	COG0438	transferase activity, transferring glycosyl groups
T2812B_RS08065	COG0463	Glycosyl transferase, family 2
T2812B_RS08080	COG0747	negative chemotaxis
T2812B_RS08085	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
T2812B_RS08090	COG1940	carbohydrate kinase activity
T2812B_RS08095	COG4166	transmembrane transport
T2812B_RS08100	COG0601	transmembrane transport
T2812B_RS08105	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
T2812B_RS08110	COG0444	Belongs to the ABC transporter superfamily
T2812B_RS08115	COG4608	Belongs to the ABC transporter superfamily
T2812B_RS08120	COG1609	Transcriptional regulator
T2812B_RS08130	COG0649	NAD binding
T2812B_RS08135	COG0649	NAD binding
T2812B_RS08135	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
T2812B_RS08140	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
T2812B_RS08150	COG0651	ATP synthesis coupled electron transport
T2812B_RS08155	COG0651	ATP synthesis coupled electron transport
T2812B_RS08165	COG2111	Na H antiporter
T2812B_RS08165	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
T2812B_RS08180	COG2212	antiporter activity
T2812B_RS08185	COG1863	multisubunit Na H antiporter MnhE subunit
T2812B_RS08190	COG2182	Extracellular solute-binding protein
T2812B_RS08195	COG1175	transmembrane transport
T2812B_RS08200	COG3833	ABC-type maltose transport systems, permease component
T2812B_RS08210	COG1609	Transcriptional regulator
T2812B_RS08220	COG3250	beta-galactosidase activity
T2812B_RS08225	COG3345	alpha-galactosidase
T2812B_RS08230	COG1085	galactose-1-phosphate uridylyltransferase
T2812B_RS08235	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
T2812B_RS08245	COG2199	diguanylate cyclase activity
T2812B_RS08260	COG0628	permease
T2812B_RS08270	COG1803	Methylglyoxal synthase
T2812B_RS08280	COG0667	Aldo Keto reductase
T2812B_RS08285	COG1196	nuclear chromosome segregation
T2812B_RS08290	COG0494	nUDIX hydrolase
T2812B_RS08300	COG1516	flagellar protein fliS
T2812B_RS08305	COG0456	acetyltransferase
T2812B_RS08315	COG1151	hydroxylamine reductase activity
T2812B_RS08330	COG1028	Short-chain dehydrogenase reductase Sdr
T2812B_RS08335	COG0058	SHG alpha-glucan phosphorylase activity
T2812B_RS08345	COG0635	Involved in the biosynthesis of porphyrin-containing compound
T2812B_RS08350	COG1013	pyruvate-flavodoxin oxidoreductase activity
T2812B_RS08360	COG2199	diguanylate cyclase activity
T2812B_RS08370	COG2239	Acts as a magnesium transporter
T2812B_RS08385	COG0010	Belongs to the arginase family
T2812B_RS08400	COG1983	PspC domain protein
T2812B_RS08405	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
T2812B_RS08410	COG0363	glucosamine-6-phosphate deaminase activity
T2812B_RS08420	COG0444	Belongs to the ABC transporter superfamily
T2812B_RS08425	COG4608	Belongs to the ABC transporter superfamily
T2812B_RS08430	COG0747	negative chemotaxis
T2812B_RS08435	COG0601	transmembrane transport
T2812B_RS08445	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
T2812B_RS08445	COG2199	diguanylate cyclase activity
T2812B_RS08465	COG0785	Cytochrome C biogenesis protein
T2812B_RS08515	COG0714	Associated with various cellular activities
T2812B_RS08520	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
T2812B_RS08525	COG0280	phosphate acetyltransferase
T2812B_RS08530	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
T2812B_RS08565	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
T2812B_RS08640	COG0651	ATP synthesis coupled electron transport
T2812B_RS08655	COG0571	ribonuclease III activity
T2812B_RS08660	COG0622	Phosphoesterase
T2812B_RS08670	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
T2812B_RS08680	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
T2812B_RS08685	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
T2812B_RS08690	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
T2812B_RS08695	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
T2812B_RS08700	COG0018	arginyl-trna synthetase
T2812B_RS08720	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
T2812B_RS08730	COG0569	domain protein
T2812B_RS08745	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
T2812B_RS08745	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
T2812B_RS08750	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
T2812B_RS08755	COG1371	PFAM Archease protein family (DUF101 UPF0211)
T2812B_RS08760	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
T2812B_RS08765	COG1366	Belongs to the anti-sigma-factor antagonist family
T2812B_RS08770	COG0698	ribose 5-phosphate isomerase
T2812B_RS08775	COG2264	protein methyltransferase activity
T2812B_RS08785	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
T2812B_RS08805	COG1070	Carbohydrate kinase
T2812B_RS08815	COG4952	isomerase
T2812B_RS08825	COG0601	transmembrane transport
T2812B_RS08830	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
T2812B_RS08835	COG0444	Belongs to the ABC transporter superfamily
T2812B_RS08840	COG4608	Belongs to the ABC transporter superfamily
T2812B_RS08855	COG3246	L-lysine catabolic process to acetate
T2812B_RS08895	COG3408	Glycogen debranching enzyme
T2812B_RS08900	COG1349	DNA-binding transcription factor activity
T2812B_RS08910	COG3250	beta-galactosidase activity
T2812B_RS08920	COG2359	stage V sporulation protein S
T2812B_RS08930	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
T2812B_RS08935	COG1324	tolerance protein
T2812B_RS08945	COG1137	ATPase activity
T2812B_RS08955	COG1555	photosystem II stabilization
T2812B_RS08955	COG1596	polysaccharide export
T2812B_RS08980	COG0850	regulation of cytokinetic process
T2812B_RS08995	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
T2812B_RS09005	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
T2812B_RS09020	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
T2812B_RS09030	COG0107	imidazoleglycerol-phosphate synthase activity
T2812B_RS09035	COG0140	phosphoribosyl-ATP diphosphatase activity
T2812B_RS09035	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
T2812B_RS09040	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
T2812B_RS09045	COG0662	Cupin 2, conserved barrel domain protein
T2812B_RS09045	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
T2812B_RS09070	COG1131	(ABC) transporter
T2812B_RS09110	COG2814	Major facilitator Superfamily
T2812B_RS09135	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
T2812B_RS09190	COG3234	Protein of unknown function (DUF1175)
T2812B_RS09200	COG2373	Large extracellular alpha-helical protein
T2812B_RS09205	COG0425	Belongs to the sulfur carrier protein TusA family
T2812B_RS09210	COG2391	methyltransferase activity
T2812B_RS09230	COG0425	Belongs to the sulfur carrier protein TusA family
T2812B_RS09235	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
T2812B_RS09240	COG0840	transmembrane signaling receptor activity
T2812B_RS09245	COG3706	GGDEF domain
T2812B_RS09270	COG4974	Belongs to the 'phage' integrase family
T2812B_RS09275	COG1606	tRNA processing
T2812B_RS09280	COG1691	(AIR) carboxylase
T2812B_RS09285	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
T2812B_RS09300	COG1704	LemA family
T2812B_RS09305	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
T2812B_RS09310	COG3959	Transketolase, thiamine diphosphate binding domain
T2812B_RS09315	COG3958	Transketolase
T2812B_RS09320	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
T2812B_RS09385	COG0174	glutamine synthetase
T2812B_RS09405	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
T2812B_RS09420	COG0402	S-adenosylhomocysteine deaminase activity
T2812B_RS09425	COG0516	GMP reductase activity
T2812B_RS09425	COG0517	IMP dehydrogenase activity
T2812B_RS09430	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
T2812B_RS09455	COG3864	Putative metallopeptidase domain
T2812B_RS09465	COG1141	Ferredoxin