locus-tag	class	description
TTHT_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
TTHT_RS00010	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
TTHT_RS00015	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
TTHT_RS00025	COG0658	competence protein
TTHT_RS00025	COG2333	competence protein COMEC
TTHT_RS00030	COG4818	TM2 domain
TTHT_RS00035	COG0183	Belongs to the thiolase family
TTHT_RS00040	COG1024	Enoyl-CoA hydratase
TTHT_RS00040	COG1250	3-hydroxyacyl-CoA dehydrogenase
TTHT_RS00055	COG1595	DNA-templated transcription, initiation
TTHT_RS00070	COG1420	regulation of RNA biosynthetic process
TTHT_RS00075	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
TTHT_RS00080	COG0443	Heat shock 70 kDa protein
TTHT_RS00140	COG2165	general secretion pathway protein
TTHT_RS00145	COG1139	Iron-sulfur cluster binding protein
TTHT_RS00170	COG2244	polysaccharide biosynthetic process
TTHT_RS00175	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
TTHT_RS00185	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
TTHT_RS00195	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
TTHT_RS00200	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
TTHT_RS00205	COG3481	metal-dependent phosphohydrolase, HD sub domain
TTHT_RS00215	COG1324	tolerance protein
TTHT_RS00220	COG0406	alpha-ribazole phosphatase activity
TTHT_RS00225	COG0018	arginyl-trna synthetase
TTHT_RS00230	COG1597	lipid kinase activity
TTHT_RS00250	COG0482	sulfurtransferase activity
TTHT_RS00260	COG3956	TIGRFAM MazG family protein
TTHT_RS00265	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
TTHT_RS00280	COG0792	nuclease activity
TTHT_RS00285	COG3051	citrate lyase alpha subunit
TTHT_RS00290	COG0012	GTP binding
TTHT_RS00305	COG1811	Na channel or pump
TTHT_RS00315	COG1773	rubredoxin
TTHT_RS00325	COG1131	(ABC) transporter
TTHT_RS00340	COG2195	Cleaves the N-terminal amino acid of tripeptides
TTHT_RS00355	COG4770	biotin carboxylase activity
TTHT_RS00360	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
TTHT_RS00375	COG0745	RESPONSE REGULATOR receiver
TTHT_RS00390	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
TTHT_RS00440	COG0739	heme binding
TTHT_RS00445	COG0653	protein targeting
TTHT_RS00450	COG0516	GMP reductase activity
TTHT_RS00450	COG0517	IMP dehydrogenase activity
TTHT_RS00455	COG0811	peptide transport
TTHT_RS00460	COG0848	biopolymer transport protein
TTHT_RS00470	COG2385	sporulation resulting in formation of a cellular spore
TTHT_RS00470	COG2385	sporulation resulting in formation of a cellular spore
TTHT_RS00475	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
TTHT_RS00485	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
TTHT_RS00485	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
TTHT_RS00510	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
TTHT_RS00520	COG1956	GAF domain-containing protein
TTHT_RS00545	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
TTHT_RS00550	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
TTHT_RS00560	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
TTHT_RS00565	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
TTHT_RS00570	COG0072	phenylalanine-tRNA ligase activity
TTHT_RS00590	COG1418	mRNA catabolic process
TTHT_RS00595	COG1692	metallophosphoesterase
TTHT_RS00605	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
TTHT_RS00620	COG3158	transport of potassium into the cell
TTHT_RS00625	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
TTHT_RS00625	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
TTHT_RS00630	COG4221	oxidoreductase activity
TTHT_RS00640	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
TTHT_RS00650	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
TTHT_RS00675	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
TTHT_RS00685	COG1760	l-serine dehydratase
TTHT_RS00695	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
TTHT_RS00725	COG2204	response regulator
TTHT_RS00730	COG3852	Histidine kinase
TTHT_RS00750	COG2217	Heavy metal translocating P-type atpase
TTHT_RS00775	COG0318	PFAM AMP-dependent synthetase and ligase
TTHT_RS00790	COG2985	domain, Protein
TTHT_RS00790	COG0490	domain, Protein
TTHT_RS00795	COG1131	(ABC) transporter
TTHT_RS00815	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
TTHT_RS00855	COG1518	maintenance of DNA repeat elements
TTHT_RS00860	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
TTHT_RS00870	COG0297	glycogen (starch) synthase activity
TTHT_RS00880	COG1543	Belongs to the glycosyl hydrolase 57 family
TTHT_RS00885	COG3328	transposase activity
TTHT_RS00900	COG3706	GGDEF domain
TTHT_RS00905	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
TTHT_RS00910	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
TTHT_RS00940	COG0489	protein tyrosine kinase activity
TTHT_RS00960	COG0179	Fumarylacetoacetate (FAA) hydrolase
TTHT_RS00990	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
TTHT_RS01000	COG0737	Belongs to the 5'-nucleotidase family
TTHT_RS01005	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
TTHT_RS01025	COG0484	heat shock protein binding
TTHT_RS01030	COG0631	protein serine/threonine phosphatase activity
TTHT_RS01075	COG0006	proline dipeptidase activity
TTHT_RS01085	COG0511	ligase activity, forming carbon-carbon bonds
TTHT_RS01090	COG0439	Biotin carboxylase
TTHT_RS01100	COG2165	general secretion pathway protein
TTHT_RS01115	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
TTHT_RS01120	COG0196	riboflavin kinase activity
TTHT_RS01125	COG1652	LysM domain
TTHT_RS01135	COG3620	sequence-specific DNA binding
TTHT_RS01135	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
TTHT_RS01135	COG0617	tRNA 3'-terminal CCA addition
TTHT_RS01140	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
TTHT_RS01145	COG0045	succinate-CoA ligase (ADP-forming) activity
TTHT_RS01150	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
TTHT_RS01160	COG0674	pyruvate-flavodoxin oxidoreductase activity
TTHT_RS01160	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
TTHT_RS01165	COG1013	pyruvate-flavodoxin oxidoreductase activity
TTHT_RS01175	COG0105	UTP biosynthetic process
TTHT_RS01185	COG1027	Aspartate ammonia-lyase
TTHT_RS01190	COG0612	Peptidase, M16
TTHT_RS01205	COG2815	serine threonine protein kinase
TTHT_RS01205	COG0515	serine threonine protein kinase
TTHT_RS01225	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
TTHT_RS01235	COG0432	Pfam Uncharacterised protein family UPF0047
TTHT_RS01240	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
TTHT_RS01245	COG5002	protein histidine kinase activity
TTHT_RS01265	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TTHT_RS01270	COG0326	Molecular chaperone. Has ATPase activity
TTHT_RS01280	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
TTHT_RS01295	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
TTHT_RS01305	COG1690	Belongs to the RtcB family
TTHT_RS01310	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
TTHT_RS01320	COG0561	phosphatase activity
TTHT_RS01325	COG0010	Belongs to the arginase family
TTHT_RS01335	COG3290	protein histidine kinase activity
TTHT_RS01345	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
TTHT_RS01360	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
TTHT_RS01370	COG3599	regulation of cell shape
TTHT_RS01385	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
TTHT_RS01390	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
TTHT_RS01395	COG0463	Glycosyl transferase, family 2
TTHT_RS01400	COG0404	The glycine cleavage system catalyzes the degradation of glycine
TTHT_RS01405	COG0509	glycine decarboxylation via glycine cleavage system
TTHT_RS01410	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
TTHT_RS01415	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
TTHT_RS01420	COG2309	aminopeptidase activity
TTHT_RS01425	COG3177	Filamentation induced by cAMP protein fic
TTHT_RS01430	COG3608	succinylglutamate desuccinylase aspartoacylase
TTHT_RS01430	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
TTHT_RS01450	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
TTHT_RS01455	COG0228	four-way junction DNA binding
TTHT_RS01460	COG1837	Belongs to the UPF0109 family
TTHT_RS01465	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
TTHT_RS01470	COG0336	Belongs to the RNA methyltransferase TrmD family
TTHT_RS01475	COG0335	large ribosomal subunit rRNA binding
TTHT_RS01485	COG0544	peptidyl-prolyl cis-trans isomerase activity
TTHT_RS01490	COG0740	serine-type endopeptidase activity
TTHT_RS01495	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
TTHT_RS01500	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
TTHT_RS01505	COG0218	Necessary for normal cell division and for the maintenance of normal septation
TTHT_RS01510	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
TTHT_RS01565	COG0681	Belongs to the peptidase S26 family
TTHT_RS01570	COG0500	methyltransferase
TTHT_RS01575	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
TTHT_RS01600	COG1028	Short-chain dehydrogenase reductase Sdr
TTHT_RS01615	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
TTHT_RS01640	COG0047	phosphoribosylformylglycinamidine synthase activity
TTHT_RS01650	COG1067	ATP-dependent peptidase activity
TTHT_RS01655	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
TTHT_RS01660	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
TTHT_RS01675	COG1271	oxidase subunit
TTHT_RS01680	COG1294	oxidase, subunit
TTHT_RS01690	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
TTHT_RS01695	COG0459	protein refolding
TTHT_RS01710	COG5002	protein histidine kinase activity
TTHT_RS01715	COG2204	response regulator
TTHT_RS01735	COG1214	PFAM Peptidase M22, glycoprotease
TTHT_RS01740	COG0456	acetyltransferase
TTHT_RS01745	COG2431	L-lysine efflux transmembrane transporter activity
TTHT_RS01775	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
TTHT_RS01785	COG0463	Glycosyl transferase, family 2
TTHT_RS01790	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
TTHT_RS01795	COG0071	Belongs to the small heat shock protein (HSP20) family
TTHT_RS01815	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
TTHT_RS01825	COG1546	Belongs to the CinA family
TTHT_RS01825	COG1058	Belongs to the CinA family
TTHT_RS01830	COG0151	Belongs to the GarS family
TTHT_RS01845	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
TTHT_RS01850	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
TTHT_RS01880	COG1074	ATP-dependent DNA helicase activity
TTHT_RS01895	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
TTHT_RS01905	COG1162	GTPase activity
TTHT_RS01910	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
TTHT_RS01915	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
TTHT_RS01920	COG0805	protein transport
TTHT_RS01940	COG0509	glycine decarboxylation via glycine cleavage system
TTHT_RS01945	COG0437	4 iron, 4 sulfur cluster binding
TTHT_RS01945	COG3064	Membrane
TTHT_RS01950	COG5557	Pfam Polysulphide reductase, NrfD
TTHT_RS01955	COG5002	protein histidine kinase activity
TTHT_RS01960	COG2204	response regulator
TTHT_RS01975	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
TTHT_RS01980	COG0261	This protein binds to 23S rRNA in the presence of protein L20
TTHT_RS01985	COG0211	Belongs to the bacterial ribosomal protein bL27 family
TTHT_RS01990	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
TTHT_RS01995	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
TTHT_RS02000	COG0799	negative regulation of ribosome biogenesis
TTHT_RS02005	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
TTHT_RS02015	COG0217	transcriptional regulatory protein
TTHT_RS02020	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
TTHT_RS02030	COG0322	excinuclease ABC activity
TTHT_RS02040	COG1250	3-hydroxyacyl-CoA dehydrogenase
TTHT_RS02050	COG1881	PFAM PEBP family protein
TTHT_RS02075	COG3852	Histidine kinase
TTHT_RS02080	COG2204	response regulator
TTHT_RS02090	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
TTHT_RS02100	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
TTHT_RS02105	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
TTHT_RS02120	COG1027	Aspartate ammonia-lyase
TTHT_RS02125	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
TTHT_RS02160	COG3706	GGDEF domain
TTHT_RS02180	COG2172	sigma factor antagonist activity
TTHT_RS02190	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
TTHT_RS02190	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
TTHT_RS02210	COG2181	nitrate reductase activity
TTHT_RS02210	COG0247	lactate metabolic process
TTHT_RS02230	COG2264	protein methyltransferase activity
TTHT_RS02245	COG0330	HflC and HflK could
TTHT_RS02265	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
TTHT_RS02270	COG0688	phosphatidylethanolamine metabolic process
TTHT_RS02275	COG3359	exonuclease
TTHT_RS02295	COG3706	GGDEF domain
TTHT_RS02300	COG4956	integral membrane protein (PIN domain superfamily)
TTHT_RS02310	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
TTHT_RS02315	COG0166	Belongs to the GPI family
TTHT_RS02325	COG0444	Belongs to the ABC transporter superfamily
TTHT_RS02330	COG4608	Belongs to the ABC transporter superfamily
TTHT_RS02335	COG3706	GGDEF domain
TTHT_RS02340	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
TTHT_RS02345	COG0066	3-isopropylmalate dehydratase activity
TTHT_RS02350	COG0745	RESPONSE REGULATOR receiver
TTHT_RS02370	COG1193	negative regulation of DNA recombination
TTHT_RS02375	COG0546	phosphoglycolate phosphatase activity
TTHT_RS02385	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TTHT_RS02385	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TTHT_RS02390	COG0549	Belongs to the carbamate kinase family
TTHT_RS02395	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
TTHT_RS02415	COG1392	Phosphate transport regulator
TTHT_RS02420	COG0306	phosphate transporter
TTHT_RS02445	COG0737	Belongs to the 5'-nucleotidase family
TTHT_RS02445	COG4085	toxin activity
TTHT_RS02445	COG1525	nuclease
TTHT_RS02460	COG1012	belongs to the aldehyde dehydrogenase family
TTHT_RS02465	COG1115	amino acid carrier protein
TTHT_RS02470	COG0667	Aldo Keto reductase
TTHT_RS02480	COG0616	signal peptide processing
TTHT_RS02495	COG0768	penicillin binding
TTHT_RS02500	COG0772	Belongs to the SEDS family
TTHT_RS02520	COG0613	PHP domain protein
TTHT_RS02555	COG0463	Glycosyl transferase, family 2
TTHT_RS02580	COG0437	4 iron, 4 sulfur cluster binding
TTHT_RS02600	COG1704	LemA family
TTHT_RS02620	COG1136	(ABC) transporter
TTHT_RS02625	COG0542	response to heat
TTHT_RS02630	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
TTHT_RS02640	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
TTHT_RS02645	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
TTHT_RS02645	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
TTHT_RS02650	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
TTHT_RS02655	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
TTHT_RS02670	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
TTHT_RS02675	COG5505	Protein of unknown function (DUF819)
TTHT_RS02685	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
TTHT_RS02690	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
TTHT_RS02690	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
TTHT_RS02695	COG0268	Binds directly to 16S ribosomal RNA
TTHT_RS02700	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
TTHT_RS02705	COG1923	regulation of RNA biosynthetic process
TTHT_RS02710	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
TTHT_RS02745	COG0163	prenyltransferase activity
TTHT_RS02750	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
TTHT_RS02755	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
TTHT_RS02760	COG1519	Transferase
TTHT_RS02760	COG0220	tRNA (guanine-N7-)-methyltransferase activity
TTHT_RS02765	COG1663	tetraacyldisaccharide 4'-kinase activity
TTHT_RS02770	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
TTHT_RS02775	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
TTHT_RS02775	COG0646	methionine synthase
TTHT_RS02780	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
TTHT_RS02780	COG0646	methionine synthase
TTHT_RS02795	COG1921	L-seryl-tRNASec selenium transferase activity
TTHT_RS02810	COG0254	rRNA binding
TTHT_RS02815	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
TTHT_RS02820	COG2890	protein-(glutamine-N5) methyltransferase activity
TTHT_RS02825	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
TTHT_RS02830	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
TTHT_RS02830	COG2199	diguanylate cyclase activity
TTHT_RS02840	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
TTHT_RS02845	COG0540	Belongs to the ATCase OTCase family
TTHT_RS02850	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
TTHT_RS02855	COG2067	long-chain fatty acid transport protein
TTHT_RS02860	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
TTHT_RS02865	COG4656	Part of a membrane complex involved in electron transport
TTHT_RS02880	COG2201	protein-glutamate methylesterase activity
TTHT_RS02885	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
TTHT_RS02895	COG0643	Histidine kinase
TTHT_RS02895	COG2198	Histidine kinase
TTHT_RS02905	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
TTHT_RS02910	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
TTHT_RS02930	COG0758	DNA mediated transformation
TTHT_RS02935	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
TTHT_RS02940	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
TTHT_RS02975	COG1960	acyl-CoA dehydrogenase activity
TTHT_RS02980	COG1960	acyl-CoA dehydrogenase activity
TTHT_RS02985	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
TTHT_RS02990	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
TTHT_RS02995	COG0058	SHG alpha-glucan phosphorylase activity
TTHT_RS03005	COG1183	phosphatidylcholine synthase activity
TTHT_RS03015	COG1366	Belongs to the anti-sigma-factor antagonist family
TTHT_RS03025	COG1297	OPT oligopeptide transporter protein
TTHT_RS03035	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
TTHT_RS03040	COG0037	tRNA processing
TTHT_RS03045	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
TTHT_RS03055	COG1100	Small GTP-binding protein
TTHT_RS03070	COG1538	Outer membrane efflux protein
TTHT_RS03090	COG1388	LysM domain
TTHT_RS03090	COG3858	chitin binding
TTHT_RS03100	COG0284	orotidine-5'-phosphate decarboxylase activity
TTHT_RS03105	COG0167	dihydroorotate dehydrogenase activity
TTHT_RS03120	COG0009	L-threonylcarbamoyladenylate synthase
TTHT_RS03125	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
TTHT_RS03130	COG3314	Sporulation integral membrane protein YlbJ
TTHT_RS03135	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
TTHT_RS03135	COG1703	isobutyryl-CoA mutase activity
TTHT_RS03135	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
TTHT_RS03155	COG2088	sporulation resulting in formation of a cellular spore
TTHT_RS03165	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
TTHT_RS03170	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
TTHT_RS03175	COG0193	aminoacyl-tRNA hydrolase activity
TTHT_RS03180	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
TTHT_RS03185	COG0360	Binds together with S18 to 16S ribosomal RNA
TTHT_RS03190	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
TTHT_RS03205	COG1442	glycosyl transferase family 8
TTHT_RS03205	COG1216	Glycosyl transferase, family 2
TTHT_RS03220	COG0601	transmembrane transport
TTHT_RS03230	COG2183	response to ionizing radiation
TTHT_RS03270	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
TTHT_RS03305	COG1131	(ABC) transporter
TTHT_RS03310	COG1725	Transcriptional regulator
TTHT_RS03315	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
TTHT_RS03325	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
TTHT_RS03330	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TTHT_RS03335	COG0113	porphobilinogen synthase activity
TTHT_RS03345	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
TTHT_RS03350	COG0714	Associated with various cellular activities
TTHT_RS03370	COG2304	oxidoreductase activity
TTHT_RS03415	COG0457	Tetratricopeptide repeat
TTHT_RS03435	COG0442	prolyl-tRNA aminoacylation
TTHT_RS03445	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
TTHT_RS03455	COG0825	malonyl-CoA metabolic process
TTHT_RS03460	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
TTHT_RS03460	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
TTHT_RS03475	COG1137	ATPase activity
TTHT_RS03480	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
TTHT_RS03485	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
TTHT_RS03495	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
TTHT_RS03505	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
TTHT_RS03510	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
TTHT_RS03515	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TTHT_RS03525	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
TTHT_RS03535	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
TTHT_RS03600	COG4964	Belongs to the GSP D family
TTHT_RS03630	COG1716	ATPase activity
TTHT_RS03660	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
TTHT_RS03665	COG3118	belongs to the thioredoxin family
TTHT_RS03670	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
TTHT_RS03670	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
TTHT_RS03695	COG0742	ribosomal rna small subunit methyltransferase
TTHT_RS03700	COG0840	transmembrane signaling receptor activity
TTHT_RS03705	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
TTHT_RS03705	COG0646	methionine synthase
TTHT_RS03715	COG0635	Involved in the biosynthesis of porphyrin-containing compound
TTHT_RS03730	COG0463	Glycosyl transferase, family 2
TTHT_RS03755	COG0492	ferredoxin-NADP+ reductase activity
TTHT_RS03775	COG1301	dicarboxylic acid transport
TTHT_RS03780	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
TTHT_RS03785	COG0739	heme binding
TTHT_RS03785	COG0741	lytic transglycosylase activity
TTHT_RS03785	COG1196	nuclear chromosome segregation
TTHT_RS03790	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TTHT_RS03795	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
TTHT_RS03800	COG0346	lactoylglutathione lyase activity
TTHT_RS03805	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
TTHT_RS03815	COG2226	methyltransferase
TTHT_RS03830	COG1305	Transglutaminase-like
TTHT_RS03835	COG0632	four-way junction helicase activity
TTHT_RS03840	COG3104	oligopeptide transport
TTHT_RS03850	COG1702	phosphate starvation-inducible protein PhoH
TTHT_RS03855	COG1480	7TM receptor with intracellular HD hydrolase
TTHT_RS03860	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
TTHT_RS03870	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
TTHT_RS03875	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
TTHT_RS03880	COG1185	polyribonucleotide nucleotidyltransferase activity
TTHT_RS03885	COG0017	Asparaginyl-tRNA synthetase
TTHT_RS03890	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TTHT_RS03900	COG1404	Belongs to the peptidase S8 family
TTHT_RS03905	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
TTHT_RS03925	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
TTHT_RS03930	COG0010	Belongs to the arginase family
TTHT_RS03935	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
TTHT_RS03940	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
TTHT_RS03950	COG1127	ABC transporter
TTHT_RS03955	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
TTHT_RS03965	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
TTHT_RS03965	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
TTHT_RS03975	COG0307	riboflavin synthase, alpha
TTHT_RS03980	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
TTHT_RS03980	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
TTHT_RS03985	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
TTHT_RS03995	COG4604	ABC transporter, ATP-binding protein
TTHT_RS04005	COG1250	3-hydroxyacyl-CoA dehydrogenase
TTHT_RS04005	COG1024	Enoyl-CoA hydratase
TTHT_RS04025	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
TTHT_RS04030	COG0484	heat shock protein binding
TTHT_RS04035	COG0733	neurotransmitter:sodium symporter activity
TTHT_RS04050	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
TTHT_RS04050	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
TTHT_RS04055	COG0802	atpase or kinase
TTHT_RS04060	COG2205	protein histidine kinase activity
TTHT_RS04060	COG0784	Response regulator, receiver
TTHT_RS04065	COG0745	RESPONSE REGULATOR receiver
TTHT_RS04070	COG0280	phosphate acetyltransferase
TTHT_RS04075	COG0280	phosphate acetyltransferase
TTHT_RS04080	COG3426	butyrate kinase activity
TTHT_RS04085	COG0537	adenosine 5'-monophosphoramidase activity
TTHT_RS04090	COG1160	GTP binding
TTHT_RS04100	COG0823	Involved in the tonB-independent uptake of proteins
TTHT_RS04100	COG1506	peptidase
TTHT_RS04105	COG1960	acyl-CoA dehydrogenase activity
TTHT_RS04115	COG0426	domain, Protein
TTHT_RS04115	COG1773	rubredoxin
TTHT_RS04135	COG0826	peptidase U32
TTHT_RS04140	COG0709	Synthesizes selenophosphate from selenide and ATP
TTHT_RS04145	COG0425	Belongs to the sulfur carrier protein TusA family
TTHT_RS04175	COG1250	3-hydroxyacyl-CoA dehydrogenase
TTHT_RS04180	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
TTHT_RS04190	COG0488	(ABC) transporter
TTHT_RS04195	COG1196	nuclear chromosome segregation
TTHT_RS04205	COG0686	Belongs to the AlaDH PNT family
TTHT_RS04210	COG0427	acetyl-CoA hydrolase
TTHT_RS04215	COG0427	acetyl-CoA hydrolase
TTHT_RS04220	COG0747	negative chemotaxis
TTHT_RS04240	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
TTHT_RS04245	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
TTHT_RS04250	COG1862	Preprotein translocase
TTHT_RS04255	COG0343	queuine tRNA-ribosyltransferase activity
TTHT_RS04260	COG2885	chlorophyll binding
TTHT_RS04285	COG1722	exodeoxyribonuclease VII activity
TTHT_RS04295	COG1971	Probably functions as a manganese efflux pump
TTHT_RS04300	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
TTHT_RS04325	COG0552	protein localization to endoplasmic reticulum
TTHT_RS04330	COG1355	regulation of microtubule-based process
TTHT_RS04335	COG1490	D-aminoacyl-tRNA deacylase activity
TTHT_RS04355	COG0305	Participates in initiation and elongation during chromosome replication
TTHT_RS04365	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
TTHT_RS04390	COG1450	Type ii and iii secretion system protein
TTHT_RS04405	COG0823	Involved in the tonB-independent uptake of proteins
TTHT_RS04405	COG1506	peptidase
TTHT_RS04410	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
TTHT_RS04415	COG0674	pyruvate-flavodoxin oxidoreductase activity
TTHT_RS04415	COG1013	pyruvate-flavodoxin oxidoreductase activity
TTHT_RS04415	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
TTHT_RS04415	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
TTHT_RS04420	COG0793	Belongs to the peptidase S41A family
TTHT_RS04420	COG4946	Tricorn protease homolog
TTHT_RS04435	COG0312	modulator of DNA gyrase
TTHT_RS04440	COG0745	RESPONSE REGULATOR receiver
TTHT_RS04465	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
TTHT_RS04470	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
TTHT_RS04475	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
TTHT_RS04480	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
TTHT_RS04485	COG5002	protein histidine kinase activity
TTHT_RS04500	COG0148	phosphopyruvate hydratase activity
TTHT_RS04535	COG0424	maF-like protein
TTHT_RS04540	COG0776	regulation of translation
TTHT_RS04545	COG0252	asparaginase activity
TTHT_RS04550	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
TTHT_RS04565	COG0826	peptidase U32
TTHT_RS04570	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
TTHT_RS04575	COG0481	GTPase activity
TTHT_RS04590	COG1136	(ABC) transporter
TTHT_RS04610	COG1476	TRANSCRIPTIONal
TTHT_RS04615	COG0355	proton-transporting ATP synthase activity, rotational mechanism
TTHT_RS04620	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
TTHT_RS04625	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
TTHT_RS04630	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
TTHT_RS04635	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
TTHT_RS04660	COG0745	RESPONSE REGULATOR receiver
TTHT_RS04675	COG0038	chloride channel
TTHT_RS04680	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
TTHT_RS04690	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
TTHT_RS04700	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
TTHT_RS04740	COG1509	lysine 2,3-aminomutase activity
TTHT_RS04775	COG2096	Adenosyltransferase
TTHT_RS04785	COG2078	PFAM AMMECR1 domain protein
TTHT_RS04790	COG0469	pyruvate kinase activity
TTHT_RS04800	COG0815	Transfers the fatty acyl group on membrane lipoproteins
TTHT_RS04805	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
TTHT_RS04820	COG0513	Belongs to the DEAD box helicase family
TTHT_RS04830	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
TTHT_RS04840	COG1121	(ABC) transporter
TTHT_RS04845	COG1108	ABC-type Mn2 Zn2 transport systems permease components
TTHT_RS04850	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
TTHT_RS04855	COG0789	Transcriptional regulator
TTHT_RS04860	COG0484	heat shock protein binding
TTHT_RS04865	COG0443	Heat shock 70 kDa protein
TTHT_RS04880	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
TTHT_RS04890	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
TTHT_RS04895	COG1082	Xylose isomerase domain protein TIM barrel
TTHT_RS04900	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
TTHT_RS04915	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
TTHT_RS04920	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
TTHT_RS04920	COG0517	IMP dehydrogenase activity
TTHT_RS04925	COG2877	3-deoxy-8-phosphooctulonate synthase activity
TTHT_RS04930	COG0504	CTP synthase activity
TTHT_RS04935	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
TTHT_RS04955	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
TTHT_RS04970	COG4555	ABC transporter
TTHT_RS04985	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
TTHT_RS04990	COG2086	electron transfer activity
TTHT_RS04995	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
TTHT_RS05000	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
TTHT_RS05005	COG0037	tRNA processing
TTHT_RS05010	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
TTHT_RS05040	COG1366	Belongs to the anti-sigma-factor antagonist family
TTHT_RS05060	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
TTHT_RS05075	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
TTHT_RS05075	COG0321	lipoyl(octanoyl) transferase activity
TTHT_RS05080	COG0617	tRNA 3'-terminal CCA addition
TTHT_RS05090	COG0183	Belongs to the thiolase family
TTHT_RS05120	COG1309	transcriptional regulator
TTHT_RS05155	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TTHT_RS05165	COG0517	IMP dehydrogenase activity
TTHT_RS05170	COG0123	including yeast histone deacetylase and acetoin utilization protein
TTHT_RS05190	COG1914	H( )-stimulated, divalent metal cation uptake system
TTHT_RS05195	COG0450	alkyl hydroperoxide reductase
TTHT_RS05210	COG1242	4 iron, 4 sulfur cluster binding
TTHT_RS05240	COG0517	IMP dehydrogenase activity
TTHT_RS05240	COG0516	GMP reductase activity
TTHT_RS05250	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
TTHT_RS05260	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
TTHT_RS05265	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
TTHT_RS05275	COG0776	regulation of translation
TTHT_RS05280	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
TTHT_RS05285	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
TTHT_RS05300	COG0037	tRNA processing
TTHT_RS05315	COG1979	alcohol dehydrogenase
TTHT_RS05350	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
TTHT_RS05375	COG0306	phosphate transporter
TTHT_RS05380	COG1392	Phosphate transport regulator
TTHT_RS05395	COG2954	triphosphatase activity
TTHT_RS05410	COG3852	Histidine kinase
TTHT_RS05415	COG2204	response regulator
TTHT_RS05430	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
TTHT_RS05445	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
TTHT_RS05445	COG1116	anion transmembrane transporter activity
TTHT_RS05460	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
TTHT_RS05480	COG0556	nucleotide-excision repair
TTHT_RS05490	COG1592	Rubrerythrin
TTHT_RS05500	COG0242	peptide deformylase activity
TTHT_RS05505	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
TTHT_RS05510	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
TTHT_RS05515	COG1132	(ABC) transporter
TTHT_RS05525	COG1561	YicC-like family, N-terminal region
TTHT_RS05535	COG0471	metal ion transport
TTHT_RS05565	COG1049	propionate catabolic process, 2-methylcitrate cycle
TTHT_RS05570	COG0024	Methionine aminopeptidase
TTHT_RS05575	COG1739	Uncharacterized protein family UPF0029
TTHT_RS05580	COG1573	uracil-dna glycosylase
TTHT_RS05585	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
TTHT_RS05595	COG0194	GDP metabolic process
TTHT_RS05600	COG2052	Domain of unknown function (DUF370)
TTHT_RS05610	COG0750	zinc metalloprotease
TTHT_RS05615	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
TTHT_RS05620	COG4589	Belongs to the CDS family
TTHT_RS05625	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
TTHT_RS05630	COG0142	geranyltranstransferase activity
TTHT_RS05640	COG0708	Exodeoxyribonuclease III
TTHT_RS05650	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
TTHT_RS05655	COG0724	RNA recognition motif
TTHT_RS05660	COG0724	RNA recognition motif
TTHT_RS05665	COG1047	Peptidyl-prolyl cis-trans
TTHT_RS05695	COG1598	PFAM Uncharacterised protein family UPF0150
TTHT_RS05720	COG0356	it plays a direct role in the translocation of protons across the membrane
TTHT_RS05725	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
TTHT_RS05730	COG0280	phosphate acetyltransferase
TTHT_RS05735	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
TTHT_RS05735	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
TTHT_RS05760	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
TTHT_RS05765	COG1215	transferase activity, transferring glycosyl groups
TTHT_RS05770	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
TTHT_RS05805	COG0681	Belongs to the peptidase S26 family
TTHT_RS05815	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
TTHT_RS05820	COG1459	type II secretion system
TTHT_RS05830	COG2165	general secretion pathway protein
TTHT_RS05835	COG1100	Small GTP-binding protein
TTHT_RS05845	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
TTHT_RS05860	COG1193	negative regulation of DNA recombination
TTHT_RS05865	COG0828	Belongs to the bacterial ribosomal protein bS21 family
TTHT_RS05875	COG0674	pyruvate-flavodoxin oxidoreductase activity
TTHT_RS05880	COG1013	pyruvate-flavodoxin oxidoreductase activity
TTHT_RS05885	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
TTHT_RS05910	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
TTHT_RS05930	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
TTHT_RS05940	COG0542	response to heat
TTHT_RS05960	COG0352	thiamine-phosphate diphosphorylase activity
TTHT_RS05970	COG2226	methyltransferase
TTHT_RS05980	COG0534	Mate efflux family protein
TTHT_RS05985	COG0483	inositol monophosphate 1-phosphatase activity
TTHT_RS05995	COG0446	pyridine nucleotide-disulphide oxidoreductase
TTHT_RS06005	COG1199	ATP-dependent helicase activity
TTHT_RS06010	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
TTHT_RS06015	COG1007	ATP synthesis coupled electron transport
TTHT_RS06020	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TTHT_RS06025	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
TTHT_RS06030	COG0713	ATP synthesis coupled electron transport
TTHT_RS06040	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TTHT_RS06065	COG0649	NAD binding
TTHT_RS06070	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TTHT_RS06075	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TTHT_RS06080	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TTHT_RS06110	COG0811	peptide transport
TTHT_RS06115	COG3328	transposase activity
TTHT_RS06125	COG3008	intermembrane lipid transfer
TTHT_RS06130	COG2995	paraquat-inducible protein a
TTHT_RS06140	COG0006	proline dipeptidase activity
TTHT_RS06145	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
TTHT_RS06165	COG0772	Belongs to the SEDS family
TTHT_RS06175	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
TTHT_RS06200	COG2001	Belongs to the MraZ family
TTHT_RS06215	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
TTHT_RS06220	COG1164	Oligoendopeptidase f
TTHT_RS06225	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
TTHT_RS06230	COG0011	TIGRFAM Protein of
TTHT_RS06240	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TTHT_RS06245	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
TTHT_RS06245	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
TTHT_RS06250	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
TTHT_RS06255	COG2022	thiamine diphosphate biosynthetic process
TTHT_RS06355	COG0333	Belongs to the bacterial ribosomal protein bL32 family
TTHT_RS06360	COG3328	transposase activity
TTHT_RS06400	COG0306	phosphate transporter
TTHT_RS06405	COG1392	Phosphate transport regulator
TTHT_RS06410	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
TTHT_RS06415	COG0052	Belongs to the universal ribosomal protein uS2 family
TTHT_RS06420	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
TTHT_RS06425	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
TTHT_RS06440	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
TTHT_RS06450	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
TTHT_RS06490	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
TTHT_RS06495	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
TTHT_RS06520	COG0564	pseudouridine synthase activity
TTHT_RS06535	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
TTHT_RS06540	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
TTHT_RS06550	COG0635	Involved in the biosynthesis of porphyrin-containing compound
TTHT_RS06555	COG0571	ribonuclease III activity
TTHT_RS06565	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
TTHT_RS06570	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
TTHT_RS06580	COG1674	ftsk spoiiie
TTHT_RS06595	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
TTHT_RS06600	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
TTHT_RS06610	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
TTHT_RS06635	COG0784	Response regulator, receiver
TTHT_RS06635	COG0835	chemotaxis
TTHT_RS06640	COG5002	protein histidine kinase activity
TTHT_RS06650	COG5001	Diguanylate cyclase
TTHT_RS06650	COG3706	GGDEF domain
TTHT_RS06650	COG2203	Gaf domain
TTHT_RS06650	COG4251	negative regulation of phosphorylation
TTHT_RS06690	COG0203	ribosomal protein L17
TTHT_RS06695	COG0202	RNA polymerase activity
TTHT_RS06700	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
TTHT_RS06705	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
TTHT_RS06715	COG0257	Belongs to the bacterial ribosomal protein bL36 family
TTHT_RS06720	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
TTHT_RS06725	COG0563	adenylate kinase activity
TTHT_RS06730	COG0201	protein transport
TTHT_RS06740	COG1841	ribosomal large subunit assembly
TTHT_RS06745	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
TTHT_RS06750	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
TTHT_RS06755	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
TTHT_RS06760	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
TTHT_RS06765	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
TTHT_RS06775	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
TTHT_RS06780	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
TTHT_RS06785	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
TTHT_RS06790	COG0255	Belongs to the universal ribosomal protein uL29 family
TTHT_RS06795	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
TTHT_RS06800	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
TTHT_RS06805	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
TTHT_RS06810	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
TTHT_RS06815	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
TTHT_RS06820	COG0089	rRNA binding
TTHT_RS06825	COG0088	Forms part of the polypeptide exit tunnel
TTHT_RS06830	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
TTHT_RS06835	COG0051	transcription antitermination factor activity, RNA binding
TTHT_RS06840	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
TTHT_RS06845	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
TTHT_RS06855	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
TTHT_RS06860	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
TTHT_RS06865	COG0085	RNA polymerase activity
TTHT_RS06875	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
TTHT_RS06885	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
TTHT_RS06905	COG0267	Belongs to the bacterial ribosomal protein bL33 family
TTHT_RS06910	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
TTHT_RS06935	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
TTHT_RS06945	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
TTHT_RS06950	COG2205	protein histidine kinase activity
TTHT_RS06950	COG0784	Response regulator, receiver
TTHT_RS06955	COG3437	response regulator, receiver
TTHT_RS06960	COG2183	response to ionizing radiation
TTHT_RS06960	COG0539	negative regulation of cytoplasmic translation
TTHT_RS06965	COG3328	transposase activity
TTHT_RS06970	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
TTHT_RS06975	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
TTHT_RS06980	COG0295	cytidine deaminase activity
TTHT_RS06990	COG1181	Belongs to the D-alanine--D-alanine ligase family
TTHT_RS06995	COG0357	Ribosomal RNA small subunit methyltransferase G
TTHT_RS07000	COG0784	Response regulator, receiver
TTHT_RS07000	COG4191	Histidine kinase
TTHT_RS07005	COG2204	response regulator
TTHT_RS07010	COG0745	RESPONSE REGULATOR receiver
TTHT_RS07025	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
TTHT_RS07030	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
TTHT_RS07045	COG3328	transposase activity
TTHT_RS07060	COG1450	Type ii and iii secretion system protein
TTHT_RS07095	COG4968	Prepilin-type N-terminal cleavage methylation domain
TTHT_RS07110	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
TTHT_RS07130	COG0126	phosphoglycerate kinase activity
TTHT_RS07130	COG0149	triose-phosphate isomerase activity
TTHT_RS07135	COG0126	phosphoglycerate kinase activity
TTHT_RS07135	COG0149	triose-phosphate isomerase activity
TTHT_RS07145	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
TTHT_RS07180	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
TTHT_RS07195	COG1040	competence protein
TTHT_RS07220	COG0489	protein tyrosine kinase activity
TTHT_RS07235	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
TTHT_RS07240	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
TTHT_RS07245	COG0390	transport system, permease component
TTHT_RS07250	COG2226	methyltransferase
TTHT_RS07265	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
TTHT_RS07275	COG1286	toxin biosynthetic process
TTHT_RS07285	COG3604	Transcriptional regulator
TTHT_RS07295	COG0470	DNA polymerase III
TTHT_RS07305	COG1716	ATPase activity
TTHT_RS07310	COG0328	RNA-DNA hybrid ribonuclease activity
TTHT_RS07315	COG0358	DNA primase activity
TTHT_RS07335	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
TTHT_RS07340	COG2003	Belongs to the UPF0758 family
TTHT_RS07345	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
TTHT_RS07355	COG2199	diguanylate cyclase activity
TTHT_RS07355	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
TTHT_RS07365	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
TTHT_RS07375	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
TTHT_RS07380	COG1496	oxidoreductase activity
TTHT_RS07385	COG5002	protein histidine kinase activity
TTHT_RS07390	COG0745	RESPONSE REGULATOR receiver
TTHT_RS07395	COG3005	denitrification pathway
TTHT_RS07415	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
TTHT_RS07425	COG3033	Beta-eliminating lyase
TTHT_RS07430	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
TTHT_RS07475	COG2204	response regulator
TTHT_RS07480	COG3852	Histidine kinase
TTHT_RS07500	COG0277	FAD linked oxidase domain protein
TTHT_RS07510	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
TTHT_RS07510	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
TTHT_RS07535	COG4232	protein-disulfide reductase activity
TTHT_RS07540	COG0247	lactate metabolic process
TTHT_RS07545	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
TTHT_RS07545	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
TTHT_RS07570	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
TTHT_RS07585	COG0612	Peptidase, M16
TTHT_RS07605	COG0237	dephospho-CoA kinase activity
TTHT_RS07610	COG1703	isobutyryl-CoA mutase activity
TTHT_RS07615	COG1960	acyl-CoA dehydrogenase activity
TTHT_RS07620	COG0793	Belongs to the peptidase S41A family
TTHT_RS07640	COG0084	hydrolase, TatD family'
TTHT_RS07645	COG1968	undecaprenyl-diphosphatase activity
TTHT_RS07655	COG1216	Glycosyl transferase, family 2
TTHT_RS07655	COG0463	Glycosyl transferase, family 2
TTHT_RS07660	COG0519	Catalyzes the synthesis of GMP from XMP
TTHT_RS07660	COG0518	GMP synthase (glutamine-hydrolyzing) activity
TTHT_RS07665	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
TTHT_RS07675	COG1077	Cell shape determining protein MreB Mrl
TTHT_RS07690	COG1045	serine acetyltransferase
TTHT_RS07695	COG1100	Small GTP-binding protein
TTHT_RS07715	COG0495	leucyl-tRNA aminoacylation
TTHT_RS07735	COG2131	deaminase
TTHT_RS07740	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
TTHT_RS07745	COG0698	ribose 5-phosphate isomerase
TTHT_RS07750	COG2235	arginine
TTHT_RS07755	COG5297	Belongs to the glycosyl hydrolase family 6
TTHT_RS07755	COG4733	cellulase activity
TTHT_RS07760	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
TTHT_RS07765	COG0084	hydrolase, TatD family'
TTHT_RS07770	COG1166	arginine decarboxylase activity
TTHT_RS07775	COG0778	Nitroreductase
TTHT_RS07785	COG0697	spore germination
TTHT_RS07815	COG2271	Major facilitator Superfamily
TTHT_RS07830	COG3706	GGDEF domain
TTHT_RS07835	COG0812	UDP-N-acetylmuramate dehydrogenase activity
TTHT_RS07840	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
TTHT_RS07845	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
TTHT_RS07865	COG0535	radical SAM domain protein
TTHT_RS07910	COG0124	histidyl-tRNA synthetase
TTHT_RS07915	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
TTHT_RS07930	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
TTHT_RS07935	COG4771	TonB-dependent receptor
TTHT_RS07950	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
TTHT_RS07955	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
TTHT_RS07960	COG0077	Prephenate dehydratase
TTHT_RS07960	COG1605	Chorismate mutase
TTHT_RS07970	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
TTHT_RS07980	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TTHT_RS07990	COG0210	DNA helicase
TTHT_RS08005	COG1100	Small GTP-binding protein
TTHT_RS08015	COG1595	DNA-templated transcription, initiation
TTHT_RS08045	COG5016	pyruvate
TTHT_RS08045	COG0511	ligase activity, forming carbon-carbon bonds
TTHT_RS08050	COG0439	Biotin carboxylase
TTHT_RS08095	COG1459	type II secretion system
TTHT_RS08105	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
TTHT_RS08110	COG1494	fructose-1,6-bisphosphatase
TTHT_RS08115	COG1960	acyl-CoA dehydrogenase activity
TTHT_RS08120	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
TTHT_RS08125	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
TTHT_RS08130	COG0515	serine threonine protein kinase
TTHT_RS08130	COG2815	serine threonine protein kinase
TTHT_RS08140	COG0736	holo-[acyl-carrier-protein] synthase activity
TTHT_RS08145	COG0359	binds to the 23S rRNA
TTHT_RS08150	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
TTHT_RS08155	COG1757	Na H antiporter
TTHT_RS08160	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
TTHT_RS08185	COG0233	cytoplasmic translational termination
TTHT_RS08190	COG0528	UMP kinase activity
TTHT_RS08195	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
TTHT_RS08205	COG0352	thiamine-phosphate diphosphorylase activity
TTHT_RS08205	COG0351	phosphomethylpyrimidine kinase
TTHT_RS08210	COG0512	Glutamine amidotransferase of anthranilate synthase
TTHT_RS08210	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
TTHT_RS08225	COG1295	ribonuclease BN
TTHT_RS08235	COG5000	phosphorelay sensor kinase activity
TTHT_RS08255	COG2848	UPF0210 protein
TTHT_RS08260	COG3830	Belongs to the UPF0237 family
TTHT_RS08275	COG1960	acyl-CoA dehydrogenase activity
TTHT_RS08285	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
TTHT_RS08290	COG0326	Molecular chaperone. Has ATPase activity
TTHT_RS08300	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
TTHT_RS08335	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
TTHT_RS08340	COG3118	belongs to the thioredoxin family
TTHT_RS08350	COG1222	aaa ATPase
TTHT_RS08370	COG1007	ATP synthesis coupled electron transport
TTHT_RS08385	COG0713	ATP synthesis coupled electron transport
TTHT_RS08390	COG0839	Belongs to the complex I subunit 6 family
TTHT_RS08395	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TTHT_RS08400	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
TTHT_RS08410	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TTHT_RS08415	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TTHT_RS08420	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TTHT_RS08430	COG3328	transposase activity
TTHT_RS08465	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
TTHT_RS08470	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
TTHT_RS08480	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
TTHT_RS08485	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
TTHT_RS08490	COG1187	pseudouridine synthase activity
TTHT_RS08500	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
TTHT_RS08505	COG0180	Tryptophanyl-tRNA synthetase
TTHT_RS08510	COG1994	Peptidase M50
TTHT_RS08515	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
TTHT_RS08520	COG2165	general secretion pathway protein
TTHT_RS08535	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
TTHT_RS08545	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TTHT_RS08550	COG1530	ribonuclease E activity
TTHT_RS08555	COG1752	Esterase of the alpha-beta hydrolase superfamily
TTHT_RS08575	COG0793	Belongs to the peptidase S41A family
TTHT_RS08575	COG4946	Tricorn protease homolog
TTHT_RS08580	COG1373	ATPase (AAA superfamily
TTHT_RS08590	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
TTHT_RS08605	COG2239	Acts as a magnesium transporter
TTHT_RS08615	COG0436	Aminotransferase
TTHT_RS08635	COG1597	lipid kinase activity
TTHT_RS08650	COG1376	ErfK ybiS ycfS ynhG family protein
TTHT_RS08660	COG1012	belongs to the aldehyde dehydrogenase family
TTHT_RS08680	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
TTHT_RS08720	COG0673	inositol 2-dehydrogenase activity
TTHT_RS08725	COG1506	peptidase
TTHT_RS08725	COG0823	Involved in the tonB-independent uptake of proteins
TTHT_RS08740	COG0463	Glycosyl transferase, family 2
TTHT_RS08750	COG0232	Belongs to the dGTPase family. Type 2 subfamily
TTHT_RS08755	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
TTHT_RS08765	COG0450	alkyl hydroperoxide reductase
TTHT_RS08770	COG2033	superoxide reductase activity
TTHT_RS08775	COG5002	protein histidine kinase activity
TTHT_RS08780	COG0251	oxidation-reduction process
TTHT_RS08785	COG2226	methyltransferase
TTHT_RS08800	COG1993	acr, cog1993
TTHT_RS08805	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
TTHT_RS08810	COG2954	triphosphatase activity
TTHT_RS08815	COG1111	helicase
TTHT_RS08815	COG1205	dead DEAH box helicase
TTHT_RS08820	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
TTHT_RS08825	COG1053	succinate dehydrogenase
TTHT_RS08830	COG2009	succinate dehydrogenase
TTHT_RS08835	COG0039	L-malate dehydrogenase activity
TTHT_RS08840	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
TTHT_RS08855	COG0557	exoribonuclease II activity
TTHT_RS08865	COG1774	PSP1 C-terminal conserved region
TTHT_RS08875	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
TTHT_RS08895	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
TTHT_RS08900	COG1489	DNA binding
TTHT_RS08905	COG0181	hydroxymethylbilane synthase activity
TTHT_RS08915	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
TTHT_RS08935	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
TTHT_RS08940	COG0564	pseudouridine synthase activity
TTHT_RS08945	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
TTHT_RS08955	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
TTHT_RS08980	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
TTHT_RS08985	COG1449	Belongs to the glycosyl hydrolase 57 family
TTHT_RS08995	COG2020	methyltransferase activity
TTHT_RS09000	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
TTHT_RS09005	COG4974	Belongs to the 'phage' integrase family
TTHT_RS09025	COG0101	tRNA pseudouridine synthase activity
TTHT_RS09035	COG0038	chloride channel
TTHT_RS09045	COG2204	response regulator
TTHT_RS09055	COG0668	transmembrane transport
TTHT_RS09070	COG0730	response to heat
TTHT_RS09085	COG0640	Transcriptional regulator
TTHT_RS09090	COG0798	PFAM Bile acid sodium symporter
TTHT_RS09095	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
TTHT_RS09130	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
TTHT_RS09135	COG0300	oxidoreductase activity
TTHT_RS09140	COG0525	valine-tRNA ligase activity
TTHT_RS09145	COG1966	Carbon starvation protein
TTHT_RS09150	COG0668	transmembrane transport
TTHT_RS09155	COG1022	Amp-dependent synthetase and ligase
TTHT_RS09160	COG1309	transcriptional regulator
TTHT_RS09165	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
TTHT_RS09170	COG0569	domain protein
TTHT_RS09210	COG5002	protein histidine kinase activity
TTHT_RS09225	COG0649	NAD binding
TTHT_RS09230	COG0649	NAD binding
TTHT_RS09235	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TTHT_RS09245	COG0651	ATP synthesis coupled electron transport
TTHT_RS09250	COG0651	ATP synthesis coupled electron transport
TTHT_RS09255	COG1006	Multisubunit Na H antiporter MnhC subunit
TTHT_RS09260	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
TTHT_RS09260	COG2111	Na H antiporter
TTHT_RS09270	COG1320	monovalent cation:proton antiporter activity
TTHT_RS09280	COG1863	multisubunit Na H antiporter MnhE subunit
TTHT_RS09290	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
TTHT_RS09320	COG1215	transferase activity, transferring glycosyl groups
TTHT_RS09330	COG0562	UDP-galactopyranose mutase
TTHT_RS09340	COG0438	transferase activity, transferring glycosyl groups
TTHT_RS09360	COG0529	Catalyzes the synthesis of activated sulfate
TTHT_RS09360	COG2895	sulfate adenylyltransferase (ATP) activity
TTHT_RS09365	COG2895	sulfate adenylyltransferase (ATP) activity
TTHT_RS09375	COG0175	sulfate reduction
TTHT_RS09380	COG0297	glycogen (starch) synthase activity
TTHT_RS09410	COG2205	protein histidine kinase activity
TTHT_RS09415	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TTHT_RS09420	COG0601	transmembrane transport
TTHT_RS09425	COG2204	response regulator
TTHT_RS09435	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
TTHT_RS09435	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
TTHT_RS09440	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
TTHT_RS09450	COG1100	Small GTP-binding protein
TTHT_RS09465	COG1028	Short-chain dehydrogenase reductase Sdr
TTHT_RS09470	COG0302	gtp cyclohydrolase
TTHT_RS09515	COG2161	toxin-antitoxin pair type II binding
TTHT_RS09525	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
TTHT_RS09640	COG0752	glycyl-tRNA synthetase alpha subunit
TTHT_RS09645	COG0751	glycine-tRNA ligase activity
TTHT_RS09655	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
TTHT_RS09690	COG1131	(ABC) transporter
TTHT_RS09730	COG0285	dihydrofolate synthase activity
TTHT_RS09735	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
TTHT_RS09745	COG1475	DNA binding
TTHT_RS09750	COG1192	Involved in chromosome partitioning
TTHT_RS09755	COG0445	tRNA wobble uridine modification
TTHT_RS09760	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
TTHT_RS09770	COG0706	membrane insertase activity
TTHT_RS09775	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
TTHT_RS09780	COG0594	ribonuclease P activity
TTHT_RS09785	COG0230	Belongs to the bacterial ribosomal protein bL34 family
TTHT_RS09790	COG0473	3-isopropylmalate dehydrogenase activity
TTHT_RS09790	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
TTHT_RS09815	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
TTHT_RS09830	COG0187	DNA topoisomerase II activity
TTHT_RS09835	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
TTHT_RS09840	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
TTHT_RS09845	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
TTHT_RS09855	COG3706	GGDEF domain
TTHT_RS09870	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
TTHT_RS09875	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
TTHT_RS09880	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
TTHT_RS09890	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
TTHT_RS09900	COG1598	PFAM Uncharacterised protein family UPF0150
TTHT_RS09935	COG0301	tRNA thio-modification
TTHT_RS09945	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
TTHT_RS09950	COG0066	3-isopropylmalate dehydratase activity
TTHT_RS09955	COG1381	Involved in DNA repair and RecF pathway recombination
TTHT_RS09980	COG0489	protein tyrosine kinase activity
TTHT_RS09985	COG1342	Belongs to the UPF0251 family
TTHT_RS09990	COG3426	butyrate kinase activity
TTHT_RS09995	COG0280	phosphate acetyltransferase
TTHT_RS10010	COG4953	penicillin-binding protein 1C
TTHT_RS10015	COG2373	Large extracellular alpha-helical protein
TTHT_RS10030	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
TTHT_RS10035	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
TTHT_RS10035	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
TTHT_RS10040	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
TTHT_RS10040	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
TTHT_RS10060	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
TTHT_RS10065	COG0281	malic enzyme
TTHT_RS10070	COG0157	Belongs to the NadC ModD family
TTHT_RS10105	COG1238	metal cluster binding
TTHT_RS10110	COG1254	Belongs to the acylphosphatase family
TTHT_RS10145	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
TTHT_RS10150	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
TTHT_RS10165	COG0731	radical SAM domain protein
TTHT_RS10165	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
TTHT_RS10190	COG0493	'glutamate synthase
TTHT_RS10200	COG0823	Involved in the tonB-independent uptake of proteins
TTHT_RS10220	COG0811	peptide transport
TTHT_RS10225	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
TTHT_RS10240	COG0497	DNA recombination
TTHT_RS10245	COG3852	Histidine kinase
TTHT_RS10255	COG0793	Belongs to the peptidase S41A family
TTHT_RS10255	COG3409	Peptidoglycan-binding domain 1 protein
TTHT_RS10290	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
TTHT_RS10300	COG0728	peptidoglycan biosynthetic process
TTHT_RS10305	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
TTHT_RS10310	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
TTHT_RS10315	COG0779	Required for maturation of 30S ribosomal subunits
TTHT_RS10320	COG0195	Participates in both transcription termination and antitermination
TTHT_RS10325	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
TTHT_RS10335	COG1550	Protein conserved in bacteria
TTHT_RS10365	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
TTHT_RS10370	COG1335	isochorismatase
TTHT_RS10375	COG0737	Belongs to the 5'-nucleotidase family
TTHT_RS10380	COG1333	cytochrome c biogenesis protein
TTHT_RS10400	COG1297	OPT oligopeptide transporter protein
TTHT_RS10410	COG1024	Enoyl-CoA hydratase
TTHT_RS10420	COG1090	epimerase
TTHT_RS10425	COG4974	Belongs to the 'phage' integrase family
TTHT_RS10430	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
TTHT_RS10430	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
TTHT_RS10430	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
TTHT_RS10445	COG0475	glutathione-regulated potassium exporter activity
TTHT_RS10470	COG2986	histidine ammonia-lyase
TTHT_RS10475	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
TTHT_RS10480	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
TTHT_RS10485	COG0227	Belongs to the bacterial ribosomal protein bL28 family
TTHT_RS10520	COG1960	acyl-CoA dehydrogenase activity
TTHT_RS10525	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
TTHT_RS10530	COG4221	oxidoreductase activity
TTHT_RS10535	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
TTHT_RS10540	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
TTHT_RS10560	COG0612	Peptidase, M16
TTHT_RS10565	COG3103	Sh3 type 3 domain protein
TTHT_RS10565	COG1388	LysM domain
TTHT_RS10565	COG0791	NLP P60 protein
TTHT_RS10570	COG0822	iron-sulfur transferase activity
TTHT_RS10575	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
TTHT_RS10580	COG0719	Fe-S assembly protein
TTHT_RS10585	COG0719	Fe-S assembly protein
TTHT_RS10595	COG1959	2 iron, 2 sulfur cluster binding
TTHT_RS10600	COG0506	proline dehydrogenase activity
TTHT_RS10605	COG5000	phosphorelay sensor kinase activity
TTHT_RS10620	COG0745	RESPONSE REGULATOR receiver
TTHT_RS10625	COG0791	NLP P60 protein
TTHT_RS10625	COG1388	LysM domain
TTHT_RS10630	COG0606	chelatase, subunit chli
TTHT_RS10635	COG0095	Lipoate-protein ligase
TTHT_RS10640	COG0138	bifunctional purine biosynthesis protein purh
TTHT_RS10655	COG0820	rRNA (adenine-C2-)-methyltransferase activity
TTHT_RS10675	COG1115	amino acid carrier protein
TTHT_RS10680	COG3706	GGDEF domain
TTHT_RS10685	COG0720	synthase
TTHT_RS10690	COG0602	queuosine metabolic process
TTHT_RS10700	COG3959	Transketolase, thiamine diphosphate binding domain
TTHT_RS10705	COG0572	uridine kinase
TTHT_RS10710	COG3958	Transketolase
TTHT_RS10715	COG2884	Cell division ATP-binding protein ftsE
TTHT_RS10725	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
TTHT_RS10730	COG1830	Aldolase
TTHT_RS10760	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain