locus-tag	class	description
THEAM_RS00005	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
THEAM_RS00010	COG0305	Participates in initiation and elongation during chromosome replication
THEAM_RS00020	COG0442	prolyl-tRNA aminoacylation
THEAM_RS00025	COG0438	transferase activity, transferring glycosyl groups
THEAM_RS00025	COG0297	glycogen (starch) synthase activity
THEAM_RS00030	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
THEAM_RS00035	COG0592	DNA-directed DNA polymerase activity
THEAM_RS00045	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
THEAM_RS00050	COG0142	geranyltranstransferase activity
THEAM_RS00055	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
THEAM_RS00185	COG0776	regulation of translation
THEAM_RS00345	COG0730	response to heat
THEAM_RS00360	COG0288	reversible hydration of carbon dioxide
THEAM_RS00370	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
THEAM_RS00380	COG0107	imidazoleglycerol-phosphate synthase activity
THEAM_RS00385	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
THEAM_RS00390	COG1635	Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur
THEAM_RS00400	COG1473	amidohydrolase
THEAM_RS00405	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
THEAM_RS00410	COG0142	geranyltranstransferase activity
THEAM_RS00425	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
THEAM_RS00430	COG1196	nuclear chromosome segregation
THEAM_RS00440	COG4231	catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates
THEAM_RS00445	COG0233	cytoplasmic translational termination
THEAM_RS00450	COG0528	UMP kinase activity
THEAM_RS00455	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
THEAM_RS00460	COG0052	Belongs to the universal ribosomal protein uS2 family
THEAM_RS00475	COG2226	methyltransferase
THEAM_RS00485	COG0730	response to heat
THEAM_RS00495	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
THEAM_RS00505	COG3679	Belongs to the UPF0342 family
THEAM_RS00525	COG0426	domain, Protein
THEAM_RS00525	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
THEAM_RS00540	COG1994	Peptidase M50
THEAM_RS00545	COG2078	PFAM AMMECR1 domain protein
THEAM_RS00550	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
THEAM_RS00560	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
THEAM_RS00565	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
THEAM_RS00570	COG1100	Small GTP-binding protein
THEAM_RS00600	COG1242	4 iron, 4 sulfur cluster binding
THEAM_RS00610	COG0799	negative regulation of ribosome biogenesis
THEAM_RS00620	COG1530	ribonuclease E activity
THEAM_RS00665	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
THEAM_RS00670	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
THEAM_RS00675	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
THEAM_RS00685	COG0740	serine-type endopeptidase activity
THEAM_RS00690	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
THEAM_RS00690	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
THEAM_RS00700	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
THEAM_RS00720	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
THEAM_RS00725	COG3174	membrane
THEAM_RS00730	COG0211	Belongs to the bacterial ribosomal protein bL27 family
THEAM_RS00735	COG0261	This protein binds to 23S rRNA in the presence of protein L20
THEAM_RS00745	COG0516	GMP reductase activity
THEAM_RS00745	COG0517	IMP dehydrogenase activity
THEAM_RS00750	COG0165	Argininosuccinate lyase
THEAM_RS00755	COG3959	Transketolase, thiamine diphosphate binding domain
THEAM_RS00760	COG3958	Transketolase
THEAM_RS00765	COG0793	Belongs to the peptidase S41A family
THEAM_RS00770	COG1073	alpha beta
THEAM_RS00770	COG2226	methyltransferase
THEAM_RS00775	COG1660	Displays ATPase and GTPase activities
THEAM_RS00785	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
THEAM_RS00795	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
THEAM_RS00810	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
THEAM_RS00815	COG0167	dihydroorotate dehydrogenase activity
THEAM_RS00820	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
THEAM_RS00835	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
THEAM_RS00845	COG0840	transmembrane signaling receptor activity
THEAM_RS00875	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
THEAM_RS00885	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
THEAM_RS00890	COG0519	Catalyzes the synthesis of GMP from XMP
THEAM_RS00890	COG0518	GMP synthase (glutamine-hydrolyzing) activity
THEAM_RS00910	COG1496	oxidoreductase activity
THEAM_RS00915	COG0758	DNA mediated transformation
THEAM_RS00925	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
THEAM_RS00930	COG0124	histidyl-tRNA synthetase
THEAM_RS00935	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
THEAM_RS00950	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
THEAM_RS00960	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
THEAM_RS00975	COG0284	orotidine-5'-phosphate decarboxylase activity
THEAM_RS00985	COG0436	Aminotransferase
THEAM_RS00995	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
THEAM_RS01000	COG1120	ATPase activity
THEAM_RS01010	COG1091	dTDP-4-dehydrorhamnose reductase activity
THEAM_RS01020	COG0583	DNA-binding transcription factor activity
THEAM_RS01035	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
THEAM_RS01055	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
THEAM_RS01060	COG0126	phosphoglycerate kinase activity
THEAM_RS01085	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
THEAM_RS01090	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
THEAM_RS01090	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
THEAM_RS01095	COG1078	dGTPase activity
THEAM_RS01100	COG0735	belongs to the Fur family
THEAM_RS01105	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
THEAM_RS01120	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
THEAM_RS01130	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
THEAM_RS01135	COG0511	ligase activity, forming carbon-carbon bonds
THEAM_RS01140	COG0439	Biotin carboxylase
THEAM_RS01165	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
THEAM_RS01170	COG1047	Peptidyl-prolyl cis-trans
THEAM_RS01175	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
THEAM_RS01180	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
THEAM_RS01185	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
THEAM_RS01195	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
THEAM_RS01200	COG1210	Utp--glucose-1-phosphate uridylyltransferase
THEAM_RS01205	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
THEAM_RS01210	COG0644	oxidoreductase
THEAM_RS01215	COG0505	Belongs to the CarA family
THEAM_RS01225	COG0512	Glutamine amidotransferase of anthranilate synthase
THEAM_RS01230	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
THEAM_RS01240	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
THEAM_RS01250	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
THEAM_RS01255	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
THEAM_RS01260	COG1185	polyribonucleotide nucleotidyltransferase activity
THEAM_RS01265	COG0756	dUTP diphosphatase activity
THEAM_RS01280	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
THEAM_RS01290	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
THEAM_RS01295	COG0049	tRNA binding
THEAM_RS01300	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
THEAM_RS01305	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
THEAM_RS01310	COG0051	transcription antitermination factor activity, RNA binding
THEAM_RS01315	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
THEAM_RS01325	COG0089	rRNA binding
THEAM_RS01330	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
THEAM_RS01335	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
THEAM_RS01340	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
THEAM_RS01345	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
THEAM_RS01350	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
THEAM_RS01360	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
THEAM_RS01365	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
THEAM_RS01375	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
THEAM_RS01380	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
THEAM_RS01385	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
THEAM_RS01390	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
THEAM_RS01395	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
THEAM_RS01400	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
THEAM_RS01405	COG1841	ribosomal large subunit assembly
THEAM_RS01410	COG0200	Binds to the 23S rRNA
THEAM_RS01415	COG0201	protein transport
THEAM_RS01420	COG0563	adenylate kinase activity
THEAM_RS01430	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
THEAM_RS01435	COG0257	Belongs to the bacterial ribosomal protein bL36 family
THEAM_RS01440	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
THEAM_RS01445	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
THEAM_RS01450	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
THEAM_RS01455	COG0202	RNA polymerase activity
THEAM_RS01460	COG0203	ribosomal protein L17
THEAM_RS01470	COG2894	cell division
THEAM_RS01475	COG0850	regulation of cytokinetic process
THEAM_RS01480	COG0010	Belongs to the arginase family
THEAM_RS01485	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
THEAM_RS01505	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
THEAM_RS01520	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
THEAM_RS01525	COG0193	aminoacyl-tRNA hydrolase activity
THEAM_RS01530	COG0360	Binds together with S18 to 16S ribosomal RNA
THEAM_RS01535	COG0629	single-stranded DNA binding
THEAM_RS01540	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
THEAM_RS01550	COG0359	binds to the 23S rRNA
THEAM_RS01560	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
THEAM_RS01565	COG0251	oxidation-reduction process
THEAM_RS01570	COG0640	Transcriptional regulator
THEAM_RS01575	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
THEAM_RS01585	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
THEAM_RS01610	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
THEAM_RS01630	COG0348	domain, Protein
THEAM_RS01640	COG2088	sporulation resulting in formation of a cellular spore
THEAM_RS01655	COG0295	cytidine deaminase activity
THEAM_RS01690	COG0067	glutamate synthase
THEAM_RS01690	COG0069	glutamate synthase activity
THEAM_RS01690	COG0070	glutamate synthase
THEAM_RS01695	COG0138	bifunctional purine biosynthesis protein purh
THEAM_RS01700	COG0330	HflC and HflK could
THEAM_RS01715	COG2264	protein methyltransferase activity
THEAM_RS01720	COG0613	PHP domain protein
THEAM_RS01745	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
THEAM_RS01750	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
THEAM_RS01755	COG0006	proline dipeptidase activity
THEAM_RS01770	COG1337	RAMP superfamily
THEAM_RS01790	COG0343	queuine tRNA-ribosyltransferase activity
THEAM_RS01800	COG0066	3-isopropylmalate dehydratase activity
THEAM_RS01805	COG0473	3-isopropylmalate dehydrogenase activity
THEAM_RS01810	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
THEAM_RS01830	COG1254	Belongs to the acylphosphatase family
THEAM_RS01835	COG0791	NLP P60 protein
THEAM_RS01835	COG1388	LysM domain
THEAM_RS01850	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
THEAM_RS01855	COG1333	cytochrome c biogenesis protein
THEAM_RS01860	COG0402	S-adenosylhomocysteine deaminase activity
THEAM_RS01865	COG0617	tRNA 3'-terminal CCA addition
THEAM_RS01875	COG0542	response to heat
THEAM_RS01880	COG1385	rRNA (uridine-N3-)-methyltransferase activity
THEAM_RS01885	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
THEAM_RS01885	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
THEAM_RS01890	COG0840	transmembrane signaling receptor activity
THEAM_RS01905	COG0564	pseudouridine synthase activity
THEAM_RS01910	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
THEAM_RS01920	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
THEAM_RS01925	COG0527	aspartate kinase activity
THEAM_RS01930	COG0303	'Molybdopterin
THEAM_RS01940	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
THEAM_RS01945	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
THEAM_RS01950	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
THEAM_RS01965	COG1420	regulation of RNA biosynthetic process
THEAM_RS01970	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
THEAM_RS01985	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
THEAM_RS01990	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
THEAM_RS02005	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
THEAM_RS02010	COG0736	holo-[acyl-carrier-protein] synthase activity
THEAM_RS02020	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
THEAM_RS02025	COG1028	Short-chain dehydrogenase reductase Sdr
THEAM_RS02055	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
THEAM_RS02060	COG0668	transmembrane transport
THEAM_RS02075	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
THEAM_RS02085	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
THEAM_RS02095	COG0859	PFAM glycosyl transferase family 9
THEAM_RS02115	COG2197	response regulator
THEAM_RS02120	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
THEAM_RS02125	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
THEAM_RS02130	COG0475	glutathione-regulated potassium exporter activity
THEAM_RS02135	COG0490	domain, Protein
THEAM_RS02145	COG0820	rRNA (adenine-C2-)-methyltransferase activity
THEAM_RS02150	COG1774	PSP1 C-terminal conserved region
THEAM_RS02185	COG0243	molybdopterin cofactor binding
THEAM_RS02200	COG0348	domain, Protein
THEAM_RS02200	COG3901	Regulator of nitric oxide reductase transcription
THEAM_RS02215	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
THEAM_RS02225	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
THEAM_RS02240	COG0254	rRNA binding
THEAM_RS02245	COG0586	Pfam SNARE associated Golgi protein
THEAM_RS02250	COG0159	tryptophan synthase activity
THEAM_RS02255	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
THEAM_RS02260	COG0805	protein transport
THEAM_RS02265	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
THEAM_RS02270	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
THEAM_RS02275	COG1830	Aldolase
THEAM_RS02285	COG0475	glutathione-regulated potassium exporter activity
THEAM_RS02285	COG0569	domain protein
THEAM_RS02290	COG0569	domain protein
THEAM_RS02300	COG0719	Fe-S assembly protein
THEAM_RS02310	COG0307	riboflavin synthase, alpha
THEAM_RS02320	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
THEAM_RS02330	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
THEAM_RS02335	COG0601	transmembrane transport
THEAM_RS02340	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
THEAM_RS02345	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
THEAM_RS02355	COG1045	serine acetyltransferase
THEAM_RS02365	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
THEAM_RS02370	COG0440	acetolactate synthase activity
THEAM_RS02375	COG0028	Belongs to the TPP enzyme family
THEAM_RS02380	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
THEAM_RS02390	COG0517	IMP dehydrogenase activity
THEAM_RS02390	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
THEAM_RS02425	COG0594	ribonuclease P activity
THEAM_RS02430	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
THEAM_RS02435	COG0706	membrane insertase activity
THEAM_RS02440	COG1253	flavin adenine dinucleotide binding
THEAM_RS02445	COG1253	flavin adenine dinucleotide binding
THEAM_RS02450	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
THEAM_RS02460	COG0649	NAD binding
THEAM_RS02470	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
THEAM_RS02475	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
THEAM_RS02480	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
THEAM_RS02480	COG2111	Na H antiporter
THEAM_RS02490	COG3259	Nickel-dependent hydrogenase
THEAM_RS02495	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
THEAM_RS02500	COG0543	2 iron, 2 sulfur cluster binding
THEAM_RS02510	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
THEAM_RS02515	COG1012	belongs to the aldehyde dehydrogenase family
THEAM_RS02525	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
THEAM_RS02535	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
THEAM_RS02545	COG1294	oxidase, subunit
THEAM_RS02555	COG1293	RNA-binding protein homologous to eukaryotic snRNP
THEAM_RS02565	COG1923	regulation of RNA biosynthetic process
THEAM_RS02570	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
THEAM_RS02575	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
THEAM_RS02580	COG2257	FlhB HrpN YscU SpaS Family
THEAM_RS02595	COG0181	hydroxymethylbilane synthase activity
THEAM_RS02600	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
THEAM_RS02605	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
THEAM_RS02610	COG0710	3-dehydroquinate dehydratase activity
THEAM_RS02615	COG1993	acr, cog1993
THEAM_RS02620	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
THEAM_RS02630	COG0860	N-Acetylmuramoyl-L-alanine amidase
THEAM_RS02635	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
THEAM_RS02650	COG0826	peptidase U32
THEAM_RS02660	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
THEAM_RS02665	COG0113	porphobilinogen synthase activity
THEAM_RS02675	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
THEAM_RS02675	COG0426	domain, Protein
THEAM_RS02680	COG0828	Belongs to the bacterial ribosomal protein bS21 family
THEAM_RS02685	COG1610	YqeY-like protein
THEAM_RS02690	COG1193	negative regulation of DNA recombination
THEAM_RS02695	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
THEAM_RS02710	COG0531	amino acid
THEAM_RS02715	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
THEAM_RS02735	COG0129	dihydroxy-acid dehydratase activity
THEAM_RS02745	COG0456	acetyltransferase
THEAM_RS02755	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
THEAM_RS02765	COG4581	dead DEAH box helicase
THEAM_RS02795	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
THEAM_RS02800	COG0556	nucleotide-excision repair
THEAM_RS02805	COG0675	Transposase, IS605 OrfB family
THEAM_RS02840	COG0569	domain protein
THEAM_RS02845	COG0436	Aminotransferase
THEAM_RS02850	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
THEAM_RS02855	COG0003	Pfam Anion-transporting ATPase
THEAM_RS02870	COG1663	tetraacyldisaccharide 4'-kinase activity
THEAM_RS02875	COG1519	Transferase
THEAM_RS02885	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
THEAM_RS02890	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
THEAM_RS02895	COG0124	histidyl-tRNA synthetase
THEAM_RS02900	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
THEAM_RS02910	COG3287	FIST C domain
THEAM_RS02910	COG2200	EAL domain
THEAM_RS02910	COG2199	diguanylate cyclase activity
THEAM_RS02920	COG1216	Glycosyl transferase, family 2
THEAM_RS02920	COG0463	Glycosyl transferase, family 2
THEAM_RS02925	COG2813	Specifically methylates the guanine in position
THEAM_RS02930	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
THEAM_RS02935	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
THEAM_RS02945	COG1091	dTDP-4-dehydrorhamnose reductase activity
THEAM_RS02950	COG0123	including yeast histone deacetylase and acetoin utilization protein
THEAM_RS02955	COG0557	exoribonuclease II activity
THEAM_RS02975	COG0148	phosphopyruvate hydratase activity
THEAM_RS02985	COG0848	biopolymer transport protein
THEAM_RS02990	COG0436	Aminotransferase
THEAM_RS03000	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
THEAM_RS03005	COG0268	Binds directly to 16S ribosomal RNA
THEAM_RS03015	COG0352	thiamine-phosphate diphosphorylase activity
THEAM_RS03025	COG0438	transferase activity, transferring glycosyl groups
THEAM_RS03035	COG0726	polysaccharide deacetylase
THEAM_RS03040	COG1132	(ABC) transporter
THEAM_RS03050	COG0438	transferase activity, transferring glycosyl groups
THEAM_RS03060	COG0039	L-malate dehydrogenase activity
THEAM_RS03075	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
THEAM_RS03085	COG3706	GGDEF domain
THEAM_RS03090	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
THEAM_RS03095	COG1410	methionine synthase
THEAM_RS03095	COG0646	methionine synthase
THEAM_RS03100	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
THEAM_RS03105	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
THEAM_RS03110	COG0571	ribonuclease III activity
THEAM_RS03125	COG0745	RESPONSE REGULATOR receiver
THEAM_RS03130	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
THEAM_RS03135	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
THEAM_RS03140	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
THEAM_RS03145	COG1234	tRNA 3'-trailer cleavage
THEAM_RS03150	COG1618	nucleotide phosphatase activity, acting on free nucleotides
THEAM_RS03155	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
THEAM_RS03180	COG0004	ammonium transporteR
THEAM_RS03190	COG0347	Belongs to the P(II) protein family
THEAM_RS03195	COG0174	glutamine synthetase
THEAM_RS03205	COG0019	diaminopimelate decarboxylase activity
THEAM_RS03215	COG0287	Prephenate dehydrogenase
THEAM_RS03240	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
THEAM_RS03245	COG0037	tRNA processing
THEAM_RS03250	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
THEAM_RS03250	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
THEAM_RS03255	COG2003	Belongs to the UPF0758 family
THEAM_RS03260	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
THEAM_RS03275	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
THEAM_RS03280	COG0101	tRNA pseudouridine synthase activity
THEAM_RS03285	COG0569	domain protein
THEAM_RS03285	COG0475	glutathione-regulated potassium exporter activity
THEAM_RS03290	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
THEAM_RS03295	COG0405	Gamma-glutamyltransferase
THEAM_RS03310	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
THEAM_RS03320	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
THEAM_RS03325	COG0149	triose-phosphate isomerase activity
THEAM_RS03330	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
THEAM_RS03335	COG0135	phosphoribosylanthranilate isomerase activity
THEAM_RS03345	COG0438	transferase activity, transferring glycosyl groups
THEAM_RS03355	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
THEAM_RS03365	COG1218	3'(2'),5'-bisphosphate nucleotidase
THEAM_RS03370	COG0471	metal ion transport
THEAM_RS03370	COG3273	potassium ion transport
THEAM_RS03375	COG0529	Catalyzes the synthesis of activated sulfate
THEAM_RS03380	COG2046	Belongs to the sulfate adenylyltransferase family
THEAM_RS03395	COG1215	transferase activity, transferring glycosyl groups
THEAM_RS03395	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
THEAM_RS03415	COG0438	transferase activity, transferring glycosyl groups
THEAM_RS03425	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
THEAM_RS03435	COG0436	Aminotransferase
THEAM_RS03455	COG1924	4 iron, 4 sulfur cluster binding
THEAM_RS03465	COG1966	Carbon starvation protein
THEAM_RS03485	COG0704	Plays a role in the regulation of phosphate uptake
THEAM_RS03490	COG1108	ABC-type Mn2 Zn2 transport systems permease components
THEAM_RS03500	COG0431	NADPH-dependent FMN reductase
THEAM_RS03505	COG1160	GTP binding
THEAM_RS03525	COG1730	sister chromatid segregation
THEAM_RS03530	COG1332	CRISPR-associated RAMP protein, Csm5 family
THEAM_RS03535	COG1851	Uncharacterised protein family (UPF0128)
THEAM_RS03545	COG1509	lysine 2,3-aminomutase activity
THEAM_RS03555	COG1058	Belongs to the CinA family
THEAM_RS03555	COG1546	Belongs to the CinA family
THEAM_RS03560	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
THEAM_RS03575	COG1040	competence protein
THEAM_RS03580	COG4608	Belongs to the ABC transporter superfamily
THEAM_RS03590	COG1162	GTPase activity
THEAM_RS03605	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
THEAM_RS03610	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
THEAM_RS03615	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
THEAM_RS03645	COG0812	UDP-N-acetylmuramate dehydrogenase activity
THEAM_RS03650	COG0504	CTP synthase activity
THEAM_RS03655	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
THEAM_RS03660	COG0047	phosphoribosylformylglycinamidine synthase activity
THEAM_RS03665	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
THEAM_RS03675	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
THEAM_RS03680	COG0358	DNA primase activity
THEAM_RS03685	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
THEAM_RS03690	COG0564	pseudouridine synthase activity
THEAM_RS03705	COG1388	LysM domain
THEAM_RS03705	COG1705	Flagellar rod assembly protein muramidase FlgJ
THEAM_RS03710	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
THEAM_RS03710	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
THEAM_RS03715	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
THEAM_RS03720	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
THEAM_RS03725	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
THEAM_RS03735	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
THEAM_RS03750	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
THEAM_RS03755	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
THEAM_RS03760	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
THEAM_RS03765	COG0839	Belongs to the complex I subunit 6 family
THEAM_RS03785	COG1007	ATP synthesis coupled electron transport
THEAM_RS03790	COG1921	L-seryl-tRNASec selenium transferase activity
THEAM_RS03795	COG4771	TonB-dependent receptor
THEAM_RS03815	COG1652	LysM domain
THEAM_RS03840	COG0312	modulator of DNA gyrase
THEAM_RS03865	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
THEAM_RS03870	COG1480	7TM receptor with intracellular HD hydrolase
THEAM_RS03875	COG1702	phosphate starvation-inducible protein PhoH
THEAM_RS03880	COG3264	Mechanosensitive ion channel
THEAM_RS03880	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
THEAM_RS03885	COG0488	(ABC) transporter
THEAM_RS03890	COG0733	neurotransmitter:sodium symporter activity
THEAM_RS03895	COG0731	radical SAM domain protein
THEAM_RS03895	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
THEAM_RS03900	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
THEAM_RS03905	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
THEAM_RS03910	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
THEAM_RS03915	COG0312	modulator of DNA gyrase
THEAM_RS03920	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
THEAM_RS03970	COG0303	'Molybdopterin
THEAM_RS03980	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
THEAM_RS03985	COG4149	molybdate abc transporter
THEAM_RS03990	COG0725	ABC transporter, periplasmic molybdate-binding protein
THEAM_RS04020	COG1215	transferase activity, transferring glycosyl groups
THEAM_RS04035	COG4122	O-methyltransferase activity
THEAM_RS04045	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
THEAM_RS04045	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
THEAM_RS04050	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
THEAM_RS04055	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
THEAM_RS04075	COG0438	transferase activity, transferring glycosyl groups
THEAM_RS04100	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
THEAM_RS04105	COG0179	Fumarylacetoacetate (FAA) hydrolase
THEAM_RS04115	COG0105	UTP biosynthetic process
THEAM_RS04120	COG1515	deoxyribonuclease V activity
THEAM_RS04135	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
THEAM_RS04140	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
THEAM_RS04150	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
THEAM_RS04150	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
THEAM_RS04155	COG2890	protein-(glutamine-N5) methyltransferase activity
THEAM_RS04160	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
THEAM_RS04165	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
THEAM_RS04170	COG0788	formyltetrahydrofolate deformylase activity
THEAM_RS04175	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
THEAM_RS04180	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
THEAM_RS04185	COG0741	lytic transglycosylase activity
THEAM_RS04185	COG1196	nuclear chromosome segregation
THEAM_RS04185	COG0739	heme binding
THEAM_RS04195	COG1424	Catalyzes the transformation of pimelate into pimeloyl- CoA with concomitant hydrolysis of ATP to AMP
THEAM_RS04210	COG2095	MarC family integral membrane protein
THEAM_RS04215	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
THEAM_RS04225	COG1301	dicarboxylic acid transport
THEAM_RS04230	COG0012	GTP binding
THEAM_RS04240	COG1074	ATP-dependent DNA helicase activity
THEAM_RS04250	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
THEAM_RS04255	COG0745	RESPONSE REGULATOR receiver
THEAM_RS04260	COG0784	Response regulator, receiver
THEAM_RS04260	COG0835	chemotaxis
THEAM_RS04270	COG0835	chemotaxis
THEAM_RS04275	COG2198	Histidine kinase
THEAM_RS04275	COG0784	Response regulator, receiver
THEAM_RS04275	COG0643	Histidine kinase
THEAM_RS04285	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
THEAM_RS04290	COG0849	cell division
THEAM_RS04300	COG1181	Belongs to the D-alanine--D-alanine ligase family
THEAM_RS04310	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
THEAM_RS04325	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
THEAM_RS04330	COG1309	transcriptional regulator
THEAM_RS04335	COG1309	transcriptional regulator
THEAM_RS04340	COG1566	PFAM secretion protein HlyD family protein
THEAM_RS04345	COG2814	Major facilitator Superfamily
THEAM_RS04360	COG1131	(ABC) transporter
THEAM_RS04400	COG1353	crispr-associated protein
THEAM_RS04405	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
THEAM_RS04420	COG0315	cyclic pyranopterin monophosphate synthase activity
THEAM_RS04420	COG0521	Mo-molybdopterin cofactor biosynthetic process
THEAM_RS04425	COG0746	molybdenum cofactor guanylyltransferase activity
THEAM_RS04445	COG1136	(ABC) transporter
THEAM_RS04445	COG0577	efflux transmembrane transporter activity
THEAM_RS04450	COG1136	(ABC) transporter
THEAM_RS04450	COG0577	efflux transmembrane transporter activity
THEAM_RS04455	COG1136	(ABC) transporter
THEAM_RS04460	COG0552	protein localization to endoplasmic reticulum
THEAM_RS04465	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
THEAM_RS04475	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
THEAM_RS04490	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
THEAM_RS04505	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
THEAM_RS04510	COG3620	sequence-specific DNA binding
THEAM_RS04510	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
THEAM_RS04510	COG0617	tRNA 3'-terminal CCA addition
THEAM_RS04530	COG1459	type II secretion system
THEAM_RS04565	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
THEAM_RS04570	COG1110	DNA topoisomerase II activity
THEAM_RS04590	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
THEAM_RS04600	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
THEAM_RS04605	COG0416	fatty acid biosynthetic process
THEAM_RS04610	COG0333	Belongs to the bacterial ribosomal protein bL32 family
THEAM_RS04625	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
THEAM_RS04640	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
THEAM_RS04645	COG4589	Belongs to the CDS family
THEAM_RS04650	COG0309	Hydrogenase expression formation protein (HypE)
THEAM_RS04655	COG0390	transport system, permease component
THEAM_RS04675	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
THEAM_RS04685	COG2204	response regulator
THEAM_RS04720	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
THEAM_RS04725	COG0019	diaminopimelate decarboxylase activity
THEAM_RS04745	COG0151	Belongs to the GarS family
THEAM_RS04750	COG0741	lytic transglycosylase activity
THEAM_RS04750	COG0739	heme binding
THEAM_RS04750	COG1196	nuclear chromosome segregation
THEAM_RS04755	COG0616	signal peptide processing
THEAM_RS04760	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
THEAM_RS04785	COG4974	Belongs to the 'phage' integrase family
THEAM_RS04805	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
THEAM_RS04810	COG1335	isochorismatase
THEAM_RS04820	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
THEAM_RS04825	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
THEAM_RS04830	COG0772	Belongs to the SEDS family
THEAM_RS04845	COG0612	Peptidase, M16
THEAM_RS04870	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
THEAM_RS04870	COG0493	'glutamate synthase
THEAM_RS04880	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
THEAM_RS04885	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
THEAM_RS04890	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
THEAM_RS04890	COG0574	Belongs to the PEP-utilizing enzyme family
THEAM_RS04895	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
THEAM_RS04900	COG0166	Belongs to the GPI family
THEAM_RS04905	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
THEAM_RS04910	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
THEAM_RS04920	COG1449	Belongs to the glycosyl hydrolase 57 family
THEAM_RS04930	COG0297	glycogen (starch) synthase activity
THEAM_RS04940	COG1543	Belongs to the glycosyl hydrolase 57 family
THEAM_RS04945	COG1940	carbohydrate kinase activity
THEAM_RS04950	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
THEAM_RS04955	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
THEAM_RS04970	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
THEAM_RS04975	COG1968	undecaprenyl-diphosphatase activity
THEAM_RS04985	COG1459	type II secretion system
THEAM_RS04990	COG0156	8-amino-7-oxononanoate synthase activity
THEAM_RS04995	COG4566	intracellular signal transduction
THEAM_RS05000	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
THEAM_RS05015	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
THEAM_RS05015	COG0069	glutamate synthase activity
THEAM_RS05020	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
THEAM_RS05025	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
THEAM_RS05030	COG0067	glutamate synthase
THEAM_RS05040	COG0133	tryptophan synthase activity
THEAM_RS05045	COG2200	EAL domain
THEAM_RS05050	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
THEAM_RS05055	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
THEAM_RS05060	COG4591	ABC-type transport system involved in lipoprotein release permease component
THEAM_RS05065	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
THEAM_RS05070	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
THEAM_RS05080	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
THEAM_RS05085	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
THEAM_RS05100	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
THEAM_RS05110	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
THEAM_RS05120	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
THEAM_RS05125	COG3383	formate dehydrogenase (NAD+) activity
THEAM_RS05130	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
THEAM_RS05145	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
THEAM_RS05155	COG1690	Belongs to the RtcB family
THEAM_RS05175	COG0517	IMP dehydrogenase activity
THEAM_RS05180	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
THEAM_RS05185	COG2252	PERMEase
THEAM_RS05190	COG0501	Belongs to the peptidase M48B family
THEAM_RS05200	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
THEAM_RS05205	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
THEAM_RS05215	COG0534	Mate efflux family protein
THEAM_RS05220	COG5000	phosphorelay sensor kinase activity
THEAM_RS05225	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
THEAM_RS05225	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
THEAM_RS05230	COG0242	peptide deformylase activity
THEAM_RS05265	COG0537	adenosine 5'-monophosphoramidase activity
THEAM_RS05270	COG0768	penicillin binding
THEAM_RS05280	COG2226	methyltransferase
THEAM_RS05285	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
THEAM_RS05300	COG1881	PFAM PEBP family protein
THEAM_RS05305	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
THEAM_RS05320	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
THEAM_RS05335	COG1796	DNA polymerase
THEAM_RS05335	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
THEAM_RS05350	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
THEAM_RS05355	COG1465	3-dehydroquinate synthase
THEAM_RS05370	COG0789	Transcriptional regulator
THEAM_RS05375	COG0542	response to heat
THEAM_RS05395	COG0859	PFAM glycosyl transferase family 9
THEAM_RS05400	COG1812	S-adenosylmethionine synthetase (AdoMet synthetase)
THEAM_RS05405	COG1331	Highly conserved protein containing a thioredoxin domain
THEAM_RS05410	COG1509	lysine 2,3-aminomutase activity
THEAM_RS05430	COG0653	protein targeting
THEAM_RS05435	COG0791	NLP P60 protein
THEAM_RS05445	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
THEAM_RS05460	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
THEAM_RS05465	COG0277	FAD linked oxidase domain protein
THEAM_RS05485	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
THEAM_RS05495	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
THEAM_RS05500	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
THEAM_RS05530	COG3852	Histidine kinase
THEAM_RS05535	COG2204	response regulator
THEAM_RS05550	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
THEAM_RS05555	COG0708	Exodeoxyribonuclease III
THEAM_RS05560	COG0811	peptide transport
THEAM_RS05565	COG2264	protein methyltransferase activity
THEAM_RS05570	COG0741	lytic transglycosylase activity
THEAM_RS05570	COG0739	heme binding
THEAM_RS05570	COG1196	nuclear chromosome segregation
THEAM_RS05575	COG0217	transcriptional regulatory protein
THEAM_RS05580	COG0864	Transcriptional regulator
THEAM_RS05585	COG0084	hydrolase, TatD family'
THEAM_RS05595	COG0018	arginyl-trna synthetase
THEAM_RS05600	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
THEAM_RS05625	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
THEAM_RS05630	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
THEAM_RS05640	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
THEAM_RS05645	COG0298	carbon dioxide binding
THEAM_RS05650	COG0375	protein maturation
THEAM_RS05655	COG2226	methyltransferase
THEAM_RS05675	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
THEAM_RS05680	COG1773	rubredoxin
THEAM_RS05685	COG0426	domain, Protein
THEAM_RS05690	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
THEAM_RS05695	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
THEAM_RS05705	COG0811	peptide transport
THEAM_RS05710	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
THEAM_RS05715	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
THEAM_RS05720	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
THEAM_RS05725	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
THEAM_RS05730	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
THEAM_RS05770	COG0745	RESPONSE REGULATOR receiver
THEAM_RS05790	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
THEAM_RS05805	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
THEAM_RS05815	COG1516	flagellar protein fliS
THEAM_RS05820	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
THEAM_RS05830	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
THEAM_RS05835	COG0457	Tetratricopeptide repeat
THEAM_RS05835	COG0463	Glycosyl transferase, family 2
THEAM_RS05850	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
THEAM_RS05850	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
THEAM_RS05855	COG0180	Tryptophanyl-tRNA synthetase
THEAM_RS05885	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
THEAM_RS05900	COG0768	penicillin binding
THEAM_RS05905	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
THEAM_RS05910	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
THEAM_RS05920	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
THEAM_RS05930	COG0322	excinuclease ABC activity
THEAM_RS05940	COG0742	ribosomal rna small subunit methyltransferase
THEAM_RS05950	COG0747	negative chemotaxis
THEAM_RS05960	COG0187	DNA topoisomerase II activity
THEAM_RS05990	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
THEAM_RS06000	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
THEAM_RS06005	COG2877	3-deoxy-8-phosphooctulonate synthase activity
THEAM_RS06015	COG1187	pseudouridine synthase activity
THEAM_RS06020	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
THEAM_RS06030	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
THEAM_RS06045	COG1187	pseudouridine synthase activity
THEAM_RS06065	COG0072	phenylalanine-tRNA ligase activity
THEAM_RS06065	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
THEAM_RS06080	COG1418	mRNA catabolic process
THEAM_RS06100	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
THEAM_RS06120	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
THEAM_RS06135	COG0698	ribose 5-phosphate isomerase
THEAM_RS06140	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
THEAM_RS06145	COG0668	transmembrane transport
THEAM_RS06150	COG0459	protein refolding
THEAM_RS06155	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
THEAM_RS06185	COG0517	IMP dehydrogenase activity
THEAM_RS06185	COG0516	GMP reductase activity
THEAM_RS06210	COG0489	protein tyrosine kinase activity
THEAM_RS06230	COG5002	protein histidine kinase activity
THEAM_RS06240	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
THEAM_RS06240	COG2050	protein possibly involved in aromatic compounds catabolism
THEAM_RS06250	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
THEAM_RS06260	COG0535	radical SAM domain protein
THEAM_RS06275	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
THEAM_RS06275	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
THEAM_RS06285	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
THEAM_RS06290	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
THEAM_RS06300	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
THEAM_RS06305	COG5002	protein histidine kinase activity
THEAM_RS06320	COG0157	Belongs to the NadC ModD family
THEAM_RS06325	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
THEAM_RS06330	COG0628	permease
THEAM_RS06335	COG0237	dephospho-CoA kinase activity
THEAM_RS06340	COG1692	metallophosphoesterase
THEAM_RS06345	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
THEAM_RS06360	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
THEAM_RS06365	COG0318	PFAM AMP-dependent synthetase and ligase
THEAM_RS06370	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
THEAM_RS06375	COG1573	uracil-dna glycosylase
THEAM_RS06380	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
THEAM_RS06385	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
THEAM_RS06395	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
THEAM_RS06400	COG1053	succinate dehydrogenase
THEAM_RS06405	COG1053	succinate dehydrogenase
THEAM_RS06410	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
THEAM_RS06415	COG2048	Heterodisulfide reductase, subunit B
THEAM_RS06430	COG0471	metal ion transport
THEAM_RS06445	COG4399	Belongs to the UPF0754 family
THEAM_RS06450	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
THEAM_RS06475	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
THEAM_RS06485	COG0463	Glycosyl transferase, family 2
THEAM_RS06490	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
THEAM_RS06505	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
THEAM_RS06525	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
THEAM_RS06530	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
THEAM_RS06535	COG0228	four-way junction DNA binding
THEAM_RS06540	COG1837	Belongs to the UPF0109 family
THEAM_RS06550	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
THEAM_RS06560	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
THEAM_RS06585	COG0432	Pfam Uncharacterised protein family UPF0047
THEAM_RS06595	COG1295	ribonuclease BN
THEAM_RS06605	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
THEAM_RS06610	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
THEAM_RS06625	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
THEAM_RS06635	COG2062	phosphohistidine phosphatase, SixA
THEAM_RS06640	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
THEAM_RS06650	COG0446	pyridine nucleotide-disulphide oxidoreductase
THEAM_RS06660	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
THEAM_RS06665	COG0820	rRNA (adenine-C2-)-methyltransferase activity
THEAM_RS06670	COG2835	tetraacyldisaccharide 4'-kinase activity
THEAM_RS06690	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
THEAM_RS06695	COG0540	Belongs to the ATCase OTCase family
THEAM_RS06705	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
THEAM_RS06720	COG4956	integral membrane protein (PIN domain superfamily)
THEAM_RS06725	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
THEAM_RS06730	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
THEAM_RS06755	COG1489	DNA binding
THEAM_RS06760	COG0588	phosphoglycerate mutase activity
THEAM_RS06765	COG0493	'glutamate synthase
THEAM_RS06770	COG4752	Belongs to the RNA methyltransferase TrmD family
THEAM_RS06775	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
THEAM_RS06785	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
THEAM_RS06800	COG1131	(ABC) transporter
THEAM_RS06805	COG4968	Prepilin-type N-terminal cleavage methylation domain
THEAM_RS06820	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
THEAM_RS06825	COG3118	belongs to the thioredoxin family
THEAM_RS06875	COG0302	gtp cyclohydrolase
THEAM_RS06880	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
THEAM_RS06885	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
THEAM_RS06890	COG0037	tRNA processing
THEAM_RS06900	COG0137	argininosuccinate synthase activity
THEAM_RS06905	COG0544	peptidyl-prolyl cis-trans isomerase activity
THEAM_RS06915	COG2205	protein histidine kinase activity
THEAM_RS06920	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
THEAM_RS06950	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
THEAM_RS06950	COG0674	pyruvate-flavodoxin oxidoreductase activity
THEAM_RS06985	COG1256	bacterial-type flagellum assembly
THEAM_RS06985	COG4786	Flagellar basal body rod
THEAM_RS07015	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
THEAM_RS07020	COG1100	Small GTP-binding protein
THEAM_RS07030	COG1013	pyruvate-flavodoxin oxidoreductase activity
THEAM_RS07035	COG0674	pyruvate-flavodoxin oxidoreductase activity
THEAM_RS07040	COG1144	Oxidoreductase
THEAM_RS07045	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
THEAM_RS07050	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
THEAM_RS07055	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
THEAM_RS07060	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
THEAM_RS07075	COG1561	YicC-like family, N-terminal region
THEAM_RS07080	COG0194	GDP metabolic process
THEAM_RS07085	COG1758	RNA polymerase activity
THEAM_RS07090	COG0543	2 iron, 2 sulfur cluster binding
THEAM_RS07095	COG0247	lactate metabolic process
THEAM_RS07105	COG2199	diguanylate cyclase activity
THEAM_RS07105	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
THEAM_RS07110	COG0045	succinate-CoA ligase (ADP-forming) activity
THEAM_RS07115	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
THEAM_RS07125	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
THEAM_RS07125	COG0674	pyruvate-flavodoxin oxidoreductase activity
THEAM_RS07130	COG1013	pyruvate-flavodoxin oxidoreductase activity
THEAM_RS07160	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
THEAM_RS07175	COG0482	sulfurtransferase activity
THEAM_RS07190	COG0481	GTPase activity
THEAM_RS07210	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
THEAM_RS07215	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
THEAM_RS07230	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
THEAM_RS07255	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
THEAM_RS07270	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
THEAM_RS07275	COG1684	flagellar biosynthetic protein fliR
THEAM_RS07280	COG1987	bacterial-type flagellum assembly
THEAM_RS07285	COG1338	Plays a role in the flagellum-specific transport system
THEAM_RS07295	COG1580	Controls the rotational direction of flagella during chemotaxis
THEAM_RS07300	COG1749	Flagellar hook protein flgE
THEAM_RS07305	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
THEAM_RS07310	COG1157	protein secretion by the type III secretion system
THEAM_RS07320	COG1766	The M ring may be actively involved in energy transduction
THEAM_RS07325	COG1677	Flagellar hook-basal body complex protein FliE
THEAM_RS07330	COG1558	bacterial-type flagellum-dependent cell motility
THEAM_RS07335	COG1815	bacterial-type flagellum-dependent cell motility
THEAM_RS07350	COG1191	sigma factor activity
THEAM_RS07355	COG0455	bacterial-type flagellum organization
THEAM_RS07360	COG1419	protein localization to endoplasmic reticulum
THEAM_RS07365	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
THEAM_RS07375	COG1706	bacterial-type flagellum-dependent cell motility
THEAM_RS07380	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
THEAM_RS07390	COG4786	Flagellar basal body rod
THEAM_RS07395	COG4786	Flagellar basal body rod
THEAM_RS07410	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
THEAM_RS07425	COG0497	DNA recombination
THEAM_RS07430	COG0218	Necessary for normal cell division and for the maintenance of normal septation
THEAM_RS07435	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
THEAM_RS07440	COG0492	ferredoxin-NADP+ reductase activity
THEAM_RS07445	COG3118	belongs to the thioredoxin family
THEAM_RS07455	COG1355	regulation of microtubule-based process
THEAM_RS07460	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
THEAM_RS07465	COG1260	myo-inositol-1-phosphate synthase
THEAM_RS07485	COG1683	Conserved Protein
THEAM_RS07490	COG0612	Peptidase, M16
THEAM_RS07495	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
THEAM_RS07500	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
THEAM_RS07510	COG1007	ATP synthesis coupled electron transport
THEAM_RS07515	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
THEAM_RS07520	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
THEAM_RS07530	COG0839	Belongs to the complex I subunit 6 family
THEAM_RS07540	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
THEAM_RS07545	COG0649	NAD binding
THEAM_RS07550	COG0649	NAD binding
THEAM_RS07550	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
THEAM_RS07555	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
THEAM_RS07565	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
THEAM_RS07575	COG0573	inorganic phosphate transmembrane transporter activity
THEAM_RS07580	COG0587	DNA-directed DNA polymerase activity
THEAM_RS07585	COG0825	malonyl-CoA metabolic process
THEAM_RS07590	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
THEAM_RS07595	COG0513	Belongs to the DEAD box helicase family
THEAM_RS07615	COG0585	pseudouridine synthase activity
THEAM_RS07620	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
THEAM_RS07625	COG2255	four-way junction helicase activity
THEAM_RS07655	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
THEAM_RS07665	COG3956	TIGRFAM MazG family protein
THEAM_RS07670	COG0215	cysteine-tRNA ligase activity
THEAM_RS07690	COG0310	cobalt ion transport
THEAM_RS07725	COG0285	dihydrofolate synthase activity
THEAM_RS07760	COG0439	Biotin carboxylase
THEAM_RS07765	COG0511	ligase activity, forming carbon-carbon bonds
THEAM_RS07765	COG5016	pyruvate
THEAM_RS07780	COG0606	chelatase, subunit chli
THEAM_RS07790	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
THEAM_RS07800	COG0335	large ribosomal subunit rRNA binding
THEAM_RS07805	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
THEAM_RS07810	COG0792	nuclease activity
THEAM_RS07815	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
THEAM_RS07835	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
THEAM_RS07845	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
THEAM_RS07850	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
THEAM_RS07855	COG2136	Putative SAM-dependent methyltransferase
THEAM_RS07855	COG2521	methyltransferase
THEAM_RS07880	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
THEAM_RS07915	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
THEAM_RS07925	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
THEAM_RS07925	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
THEAM_RS07940	COG0585	pseudouridine synthase activity
THEAM_RS07945	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
THEAM_RS07955	COG0739	heme binding
THEAM_RS07955	COG1196	nuclear chromosome segregation
THEAM_RS07955	COG0741	lytic transglycosylase activity
THEAM_RS07965	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
THEAM_RS07970	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
THEAM_RS07980	COG0222	ribosome binding
THEAM_RS07985	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
THEAM_RS07990	COG0081	regulation of translation
THEAM_RS07995	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
THEAM_RS08000	COG0250	Participates in transcription elongation, termination and antitermination
THEAM_RS08005	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
THEAM_RS08015	COG0267	Belongs to the bacterial ribosomal protein bL33 family
THEAM_RS08020	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
THEAM_RS08040	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
THEAM_RS08045	COG0336	Belongs to the RNA methyltransferase TrmD family
THEAM_RS08070	COG1605	Chorismate mutase
THEAM_RS08070	COG0077	Prephenate dehydratase
THEAM_RS08090	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
THEAM_RS08115	COG0356	it plays a direct role in the translocation of protons across the membrane
THEAM_RS08120	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
THEAM_RS08130	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
THEAM_RS08130	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
THEAM_RS08140	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
THEAM_RS08150	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
THEAM_RS08180	COG1203	CRISPR-associated helicase, Cas3
THEAM_RS08195	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
THEAM_RS08210	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
THEAM_RS08220	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
THEAM_RS08220	COG0574	Belongs to the PEP-utilizing enzyme family
THEAM_RS08225	COG0751	glycine-tRNA ligase activity
THEAM_RS08230	COG0752	glycyl-tRNA synthetase alpha subunit
THEAM_RS08245	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
THEAM_RS08255	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
THEAM_RS08300	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
THEAM_RS08305	COG0726	polysaccharide deacetylase
THEAM_RS08310	COG0463	Glycosyl transferase, family 2
THEAM_RS08315	COG0438	transferase activity, transferring glycosyl groups
THEAM_RS08325	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
THEAM_RS08375	COG0154	amidase activity
THEAM_RS08380	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
THEAM_RS08395	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
THEAM_RS08415	COG0482	sulfurtransferase activity
THEAM_RS08420	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
THEAM_RS08435	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
THEAM_RS08440	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
THEAM_RS08445	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
THEAM_RS08450	COG0355	proton-transporting ATP synthase activity, rotational mechanism
THEAM_RS08460	COG0531	amino acid
THEAM_RS08485	COG0445	tRNA wobble uridine modification
THEAM_RS08490	COG0357	Ribosomal RNA small subunit methyltransferase G
THEAM_RS08510	COG0083	homoserine kinase activity
THEAM_RS08530	COG0525	valine-tRNA ligase activity
THEAM_RS08550	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
THEAM_RS08570	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
THEAM_RS08600	COG0195	Participates in both transcription termination and antitermination
THEAM_RS08605	COG0779	Required for maturation of 30S ribosomal subunits
THEAM_RS08610	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
THEAM_RS08615	COG0539	negative regulation of cytoplasmic translation
THEAM_RS08620	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
THEAM_RS08630	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
THEAM_RS08635	COG0004	ammonium transporteR
THEAM_RS08640	COG0275	rRNA processing
THEAM_RS08645	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
THEAM_RS08670	COG0635	Involved in the biosynthesis of porphyrin-containing compound
THEAM_RS08680	COG3339	Conserved Protein
THEAM_RS08720	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
THEAM_RS08725	COG1238	metal cluster binding
THEAM_RS08740	COG0750	zinc metalloprotease
THEAM_RS08745	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
THEAM_RS08780	COG0227	Belongs to the bacterial ribosomal protein bL28 family
THEAM_RS08790	COG0134	indole-3-glycerol-phosphate synthase activity
THEAM_RS08795	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
THEAM_RS08855	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
THEAM_RS08895	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
THEAM_RS09220	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
THEAM_RS09225	COG1635	Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur
THEAM_RS09255	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
THEAM_RS09270	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
THEAM_RS09380	COG0490	domain, Protein
THEAM_RS09390	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
THEAM_RS09405	COG1214	PFAM Peptidase M22, glycoprotease
THEAM_RS09415	COG2226	methyltransferase
THEAM_RS09425	COG1045	serine acetyltransferase
THEAM_RS09430	COG1309	transcriptional regulator
THEAM_RS09440	COG3706	GGDEF domain
THEAM_RS09445	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
THEAM_RS09445	COG3264	Mechanosensitive ion channel
THEAM_RS09460	COG3706	GGDEF domain
THEAM_RS09470	COG0741	lytic transglycosylase activity
THEAM_RS09480	COG0310	cobalt ion transport
THEAM_RS09490	COG3300	MHYT domain
THEAM_RS09490	COG5001	Diguanylate cyclase
THEAM_RS09495	COG0824	Thioesterase
THEAM_RS09500	COG2199	diguanylate cyclase activity
THEAM_RS09500	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain