locus-tag	class	description
TO73_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
TO73_RS00015	COG0148	phosphopyruvate hydratase activity
TO73_RS00020	COG0469	pyruvate kinase activity
TO73_RS00025	COG2010	Cytochrome c
TO73_RS00035	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TO73_RS00040	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
TO73_RS00055	COG1842	Phage shock protein A
TO73_RS00070	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
TO73_RS00080	COG1278	Cold shock
TO73_RS00085	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
TO73_RS00110	COG2860	membrane
TO73_RS00115	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
TO73_RS00145	COG0459	protein refolding
TO73_RS00150	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
TO73_RS00155	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
TO73_RS00165	COG1653	transport
TO73_RS00185	COG0033	Phosphoglucomutase
TO73_RS00210	COG0517	IMP dehydrogenase activity
TO73_RS00210	COG0516	GMP reductase activity
TO73_RS00215	COG1950	PFAM Membrane protein of
TO73_RS00240	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
TO73_RS00245	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
TO73_RS00255	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
TO73_RS00260	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
TO73_RS00265	COG1496	oxidoreductase activity
TO73_RS00275	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
TO73_RS00280	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
TO73_RS00285	COG1993	acr, cog1993
TO73_RS00290	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
TO73_RS00300	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
TO73_RS00310	COG1335	isochorismatase
TO73_RS00315	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
TO73_RS00320	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
TO73_RS00320	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
TO73_RS00350	COG0267	Belongs to the bacterial ribosomal protein bL33 family
TO73_RS00355	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
TO73_RS00360	COG0250	Participates in transcription elongation, termination and antitermination
TO73_RS00370	COG0081	regulation of translation
TO73_RS00375	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
TO73_RS00380	COG0222	ribosome binding
TO73_RS00385	COG0163	prenyltransferase activity
TO73_RS00390	COG1960	acyl-CoA dehydrogenase activity
TO73_RS00395	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
TO73_RS00400	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
TO73_RS00410	COG1598	PFAM Uncharacterised protein family UPF0150
TO73_RS00415	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
TO73_RS00420	COG0066	3-isopropylmalate dehydratase activity
TO73_RS00435	COG0189	ligase activity
TO73_RS00440	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
TO73_RS00445	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
TO73_RS00450	COG1543	Belongs to the glycosyl hydrolase 57 family
TO73_RS00455	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
TO73_RS00455	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
TO73_RS00460	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
TO73_RS00465	COG1832	CoA-binding protein
TO73_RS00485	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
TO73_RS00500	COG1388	LysM domain
TO73_RS00500	COG3942	CHAP domain
TO73_RS00515	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
TO73_RS00525	COG1694	Mazg nucleotide pyrophosphohydrolase
TO73_RS00530	COG1363	Peptidase, m42
TO73_RS00535	COG1803	Methylglyoxal synthase
TO73_RS00545	COG2271	Major facilitator Superfamily
TO73_RS00565	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
TO73_RS00590	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
TO73_RS00595	COG0359	binds to the 23S rRNA
TO73_RS00605	COG0300	oxidoreductase activity
TO73_RS00610	COG0321	lipoyl(octanoyl) transferase activity
TO73_RS00615	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
TO73_RS00630	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
TO73_RS00640	COG1598	PFAM Uncharacterised protein family UPF0150
TO73_RS00645	COG0022	dehydrogenase e1 component
TO73_RS00650	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
TO73_RS00655	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
TO73_RS00685	COG0432	Pfam Uncharacterised protein family UPF0047
TO73_RS00690	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
TO73_RS00700	COG0668	transmembrane transport
TO73_RS00705	COG3253	May function as heme-dependent peroxidase
TO73_RS00715	COG0632	four-way junction helicase activity
TO73_RS00720	COG1024	Enoyl-CoA hydratase
TO73_RS00730	COG0508	dehydrogenase complex catalyzes the overall conversion of
TO73_RS00735	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
TO73_RS00740	COG1404	Belongs to the peptidase S8 family
TO73_RS00750	COG0137	argininosuccinate synthase activity
TO73_RS00755	COG0165	Argininosuccinate lyase
TO73_RS00770	COG0505	Belongs to the CarA family
TO73_RS00775	COG2759	Belongs to the formate--tetrahydrofolate ligase family
TO73_RS00795	COG0582	viral genome integration into host DNA
TO73_RS00805	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
TO73_RS00845	COG0210	DNA helicase
TO73_RS01030	COG0261	This protein binds to 23S rRNA in the presence of protein L20
TO73_RS01035	COG0211	Belongs to the bacterial ribosomal protein bL27 family
TO73_RS01040	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
TO73_RS01045	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
TO73_RS01060	COG0799	negative regulation of ribosome biogenesis
TO73_RS01070	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
TO73_RS01095	COG0739	heme binding
TO73_RS01105	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
TO73_RS01110	COG0825	malonyl-CoA metabolic process
TO73_RS01135	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
TO73_RS01145	COG1278	Cold shock
TO73_RS01150	COG0484	heat shock protein binding
TO73_RS01155	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
TO73_RS01160	COG1968	undecaprenyl-diphosphatase activity
TO73_RS01165	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
TO73_RS01170	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
TO73_RS01185	COG1309	transcriptional regulator
TO73_RS01190	COG4242	Belongs to the peptidase S51 family
TO73_RS01195	COG2389	metal-binding protein
TO73_RS01220	COG0437	4 iron, 4 sulfur cluster binding
TO73_RS01245	COG3706	GGDEF domain
TO73_RS01250	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
TO73_RS01255	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
TO73_RS01270	COG0438	transferase activity, transferring glycosyl groups
TO73_RS01280	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
TO73_RS01285	COG1185	polyribonucleotide nucleotidyltransferase activity
TO73_RS01295	COG0416	fatty acid biosynthetic process
TO73_RS01300	COG1371	PFAM Archease protein family (DUF101 UPF0211)
TO73_RS01305	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
TO73_RS01320	COG0284	orotidine-5'-phosphate decarboxylase activity
TO73_RS01325	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
TO73_RS01335	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
TO73_RS01355	COG0822	iron-sulfur transferase activity
TO73_RS01360	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
TO73_RS01405	COG0719	Fe-S assembly protein
TO73_RS01410	COG0719	Fe-S assembly protein
TO73_RS01415	COG0396	ATPase activity
TO73_RS01430	COG0446	pyridine nucleotide-disulphide oxidoreductase
TO73_RS01435	COG4181	ATPase activity
TO73_RS01440	COG0577	efflux transmembrane transporter activity
TO73_RS01440	COG1136	(ABC) transporter
TO73_RS01450	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
TO73_RS01460	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
TO73_RS01470	COG1175	transmembrane transport
TO73_RS01525	COG1058	Belongs to the CinA family
TO73_RS01525	COG1546	Belongs to the CinA family
TO73_RS01530	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
TO73_RS01540	COG1418	mRNA catabolic process
TO73_RS01540	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
TO73_RS01545	COG1077	Cell shape determining protein MreB Mrl
TO73_RS01550	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
TO73_RS01570	COG0235	Class ii aldolase
TO73_RS01595	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
TO73_RS01605	COG1607	acyl-coa hydrolase
TO73_RS01610	COG2154	pterin-4-alpha-carbinolamine dehydratase
TO73_RS01620	COG0277	FAD linked oxidase domain protein
TO73_RS01665	COG0667	Aldo Keto reductase
TO73_RS01685	COG1067	ATP-dependent peptidase activity
TO73_RS01690	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
TO73_RS01700	COG0745	RESPONSE REGULATOR receiver
TO73_RS01710	COG0297	glycogen (starch) synthase activity
TO73_RS01720	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
TO73_RS01725	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
TO73_RS01740	COG0142	geranyltranstransferase activity
TO73_RS01750	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
TO73_RS01785	COG0049	tRNA binding
TO73_RS01800	COG0051	transcription antitermination factor activity, RNA binding
TO73_RS01810	COG0088	Forms part of the polypeptide exit tunnel
TO73_RS01815	COG0089	rRNA binding
TO73_RS01820	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
TO73_RS01825	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
TO73_RS01835	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
TO73_RS01840	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
TO73_RS01845	COG0255	Belongs to the universal ribosomal protein uL29 family
TO73_RS01905	COG0201	protein transport
TO73_RS01910	COG0563	adenylate kinase activity
TO73_RS01920	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
TO73_RS01930	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
TO73_RS01935	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
TO73_RS01940	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
TO73_RS01950	COG0203	ribosomal protein L17
TO73_RS01960	COG0697	spore germination
TO73_RS01985	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
TO73_RS02000	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
TO73_RS02005	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
TO73_RS02035	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
TO73_RS02045	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
TO73_RS02050	COG2385	sporulation resulting in formation of a cellular spore
TO73_RS02055	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
TO73_RS02065	COG0194	GDP metabolic process
TO73_RS02075	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
TO73_RS02080	COG1438	arginine binding
TO73_RS02085	COG2095	MarC family integral membrane protein
TO73_RS02095	COG0497	DNA recombination
TO73_RS02110	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
TO73_RS02125	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
TO73_RS02135	COG0047	phosphoribosylformylglycinamidine synthase activity
TO73_RS02145	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
TO73_RS02160	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
TO73_RS02185	COG0546	phosphoglycolate phosphatase activity
TO73_RS02200	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
TO73_RS02235	COG5002	protein histidine kinase activity
TO73_RS02235	COG3850	Histidine kinase
TO73_RS02250	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
TO73_RS02250	COG0574	Belongs to the PEP-utilizing enzyme family
TO73_RS02255	COG0714	Associated with various cellular activities
TO73_RS02260	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
TO73_RS02265	COG1310	metal-dependent protease of the Pad1 Jab1 superfamily
TO73_RS02275	COG0483	inositol monophosphate 1-phosphatase activity
TO73_RS02280	COG0135	phosphoribosylanthranilate isomerase activity
TO73_RS02285	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
TO73_RS02285	COG1372	Participates in initiation and elongation during chromosome replication
TO73_RS02290	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TO73_RS02295	COG0537	adenosine 5'-monophosphoramidase activity
TO73_RS02305	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
TO73_RS02315	COG2911	Protein conserved in bacteria
TO73_RS02315	COG1361	Conserved repeat domain
TO73_RS02315	COG3266	domain, Protein
TO73_RS02320	COG1011	Hydrolase
TO73_RS02325	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
TO73_RS02345	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
TO73_RS02350	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
TO73_RS02355	COG0823	Involved in the tonB-independent uptake of proteins
TO73_RS02355	COG1506	peptidase
TO73_RS02355	COG4946	Tricorn protease homolog
TO73_RS02380	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
TO73_RS02385	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
TO73_RS02390	COG0113	porphobilinogen synthase activity
TO73_RS02405	COG0631	protein serine/threonine phosphatase activity
TO73_RS02410	COG0515	serine threonine protein kinase
TO73_RS02410	COG2815	serine threonine protein kinase
TO73_RS02440	COG0210	DNA helicase
TO73_RS02445	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
TO73_RS02450	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
TO73_RS02455	COG0504	CTP synthase activity
TO73_RS02475	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
TO73_RS02480	COG2010	Cytochrome c
TO73_RS02500	COG2010	Cytochrome c
TO73_RS02505	COG3258	Cytochrome c
TO73_RS02520	COG0446	pyridine nucleotide-disulphide oxidoreductase
TO73_RS02535	COG0785	Cytochrome C biogenesis protein
TO73_RS02540	COG4133	protoheme IX ABC transporter activity
TO73_RS02550	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
TO73_RS02555	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
TO73_RS02560	COG1138	Cytochrome C-type biogenesis protein
TO73_RS02565	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
TO73_RS02570	COG3088	subunit of a heme lyase
TO73_RS02580	COG0723	plastoquinol--plastocyanin reductase activity
TO73_RS02590	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
TO73_RS02600	COG0268	Binds directly to 16S ribosomal RNA
TO73_RS02610	COG0083	homoserine kinase activity
TO73_RS02620	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
TO73_RS02620	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
TO73_RS02625	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
TO73_RS02645	COG1160	GTP binding
TO73_RS02660	COG0736	holo-[acyl-carrier-protein] synthase activity
TO73_RS02665	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
TO73_RS02665	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
TO73_RS02670	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
TO73_RS02675	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
TO73_RS02680	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
TO73_RS02710	COG0473	3-isopropylmalate dehydrogenase activity
TO73_RS02740	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
TO73_RS02750	COG0860	N-Acetylmuramoyl-L-alanine amidase
TO73_RS02760	COG1752	Esterase of the alpha-beta hydrolase superfamily
TO73_RS02770	COG1556	Lactate utilization protein
TO73_RS02780	COG0247	lactate metabolic process
TO73_RS02785	COG2205	protein histidine kinase activity
TO73_RS02805	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
TO73_RS02820	COG1324	tolerance protein
TO73_RS02825	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
TO73_RS02830	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
TO73_RS02835	COG0739	heme binding
TO73_RS02835	COG1196	nuclear chromosome segregation
TO73_RS02835	COG0741	lytic transglycosylase activity
TO73_RS02840	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
TO73_RS02845	COG2197	response regulator
TO73_RS02860	COG1132	(ABC) transporter
TO73_RS02865	COG1132	(ABC) transporter
TO73_RS02870	COG0285	dihydrofolate synthase activity
TO73_RS02880	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TO73_RS02885	COG0601	transmembrane transport
TO73_RS02890	COG0747	negative chemotaxis
TO73_RS02920	COG0174	glutamine synthetase
TO73_RS02925	COG0737	Belongs to the 5'-nucleotidase family
TO73_RS02935	COG2010	Cytochrome c
TO73_RS02955	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
TO73_RS02960	COG0788	formyltetrahydrofolate deformylase activity
TO73_RS02975	COG2358	TRAP transporter, solute receptor (TAXI family
TO73_RS02980	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
TO73_RS02985	COG2358	TRAP transporter, solute receptor (TAXI family
TO73_RS03000	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
TO73_RS03010	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
TO73_RS03015	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
TO73_RS03035	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
TO73_RS03040	COG1414	Transcriptional regulator
TO73_RS03045	COG0789	Transcriptional regulator
TO73_RS03055	COG2045	Belongs to the ComB family
TO73_RS03060	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
TO73_RS03065	COG1136	(ABC) transporter
TO73_RS03070	COG0813	purine-nucleoside phosphorylase activity
TO73_RS03075	COG1024	Enoyl-CoA hydratase
TO73_RS03095	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TO73_RS03100	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
TO73_RS03115	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
TO73_RS03130	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
TO73_RS03145	COG2890	protein-(glutamine-N5) methyltransferase activity
TO73_RS03150	COG1837	Belongs to the UPF0109 family
TO73_RS03155	COG0706	membrane insertase activity
TO73_RS03160	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
TO73_RS03180	COG0318	PFAM AMP-dependent synthetase and ligase
TO73_RS03210	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
TO73_RS03215	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
TO73_RS03220	COG0333	Belongs to the bacterial ribosomal protein bL32 family
TO73_RS03295	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
TO73_RS03305	COG1760	l-serine dehydratase
TO73_RS03315	COG0481	GTPase activity
TO73_RS03320	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
TO73_RS03320	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
TO73_RS03330	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
TO73_RS03340	COG0195	Participates in both transcription termination and antitermination
TO73_RS03345	COG0779	Required for maturation of 30S ribosomal subunits
TO73_RS03365	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
TO73_RS03365	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
TO73_RS03375	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
TO73_RS03375	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
TO73_RS03395	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
TO73_RS03395	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
TO73_RS03400	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
TO73_RS03400	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
TO73_RS03405	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
TO73_RS03425	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
TO73_RS03430	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
TO73_RS03435	COG1702	phosphate starvation-inducible protein PhoH
TO73_RS03435	COG1702	phosphate starvation-inducible protein PhoH
TO73_RS03445	COG4864	UPF0365 protein
TO73_RS03455	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
TO73_RS03470	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
TO73_RS03475	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
TO73_RS03480	COG0824	Thioesterase
TO73_RS03490	COG0557	exoribonuclease II activity
TO73_RS03495	COG1355	regulation of microtubule-based process
TO73_RS03500	COG0617	tRNA 3'-terminal CCA addition
TO73_RS03500	COG1353	crispr-associated protein
TO73_RS03505	COG0237	dephospho-CoA kinase activity
TO73_RS03520	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
TO73_RS03525	COG0165	Argininosuccinate lyase
TO73_RS03540	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
TO73_RS03545	COG2239	Acts as a magnesium transporter
TO73_RS03555	COG0589	response to stress
TO73_RS03560	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
TO73_RS03565	COG1185	polyribonucleotide nucleotidyltransferase activity
TO73_RS03570	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
TO73_RS03585	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
TO73_RS03590	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
TO73_RS03600	COG1100	Small GTP-binding protein
TO73_RS03615	COG0010	Belongs to the arginase family
TO73_RS03630	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
TO73_RS03635	COG0511	ligase activity, forming carbon-carbon bonds
TO73_RS03640	COG0439	Biotin carboxylase
TO73_RS03650	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
TO73_RS03655	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
TO73_RS03660	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
TO73_RS03670	COG2181	nitrate reductase activity
TO73_RS03670	COG0247	lactate metabolic process
TO73_RS03680	COG2819	hydrolase of the alpha beta superfamily
TO73_RS03695	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
TO73_RS03745	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
TO73_RS03755	COG0438	transferase activity, transferring glycosyl groups
TO73_RS03770	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
TO73_RS03775	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
TO73_RS03780	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
TO73_RS03785	COG0662	Cupin 2, conserved barrel domain protein
TO73_RS03785	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
TO73_RS03805	COG0438	transferase activity, transferring glycosyl groups
TO73_RS03825	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
TO73_RS03835	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
TO73_RS03840	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
TO73_RS03850	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
TO73_RS03870	COG0582	viral genome integration into host DNA
TO73_RS03970	COG0183	Belongs to the thiolase family
TO73_RS03980	COG1804	L-carnitine dehydratase bile acid-inducible protein F
TO73_RS04000	COG1129	ABC transporter
TO73_RS04005	COG4603	Belongs to the binding-protein-dependent transport system permease family
TO73_RS04010	COG1079	Belongs to the binding-protein-dependent transport system permease family
TO73_RS04020	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
TO73_RS04025	COG0494	nUDIX hydrolase
TO73_RS04035	COG0138	bifunctional purine biosynthesis protein purh
TO73_RS04040	COG3239	Fatty acid desaturase
TO73_RS04045	COG1490	D-aminoacyl-tRNA deacylase activity
TO73_RS04050	COG1307	EDD domain protein, DegV family
TO73_RS04055	COG1307	EDD domain protein, DegV family
TO73_RS04070	COG0019	diaminopimelate decarboxylase activity
TO73_RS04075	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
TO73_RS04085	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
TO73_RS04090	COG0574	Belongs to the PEP-utilizing enzyme family
TO73_RS04090	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
TO73_RS04095	COG1492	cobalamin metabolic process
TO73_RS04110	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
TO73_RS04115	COG1980	fructose-bisphosphate aldolase activity
TO73_RS04130	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
TO73_RS04135	COG0588	phosphoglycerate mutase activity
TO73_RS04145	COG0393	Putative heavy-metal-binding
TO73_RS04150	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
TO73_RS04165	COG1797	cobyrinic acid a,c-diamide synthase activity
TO73_RS04170	COG2046	Belongs to the sulfate adenylyltransferase family
TO73_RS04175	COG1648	precorrin-2 dehydrogenase activity
TO73_RS04175	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
TO73_RS04180	COG0730	response to heat
TO73_RS04185	COG0175	sulfate reduction
TO73_RS04190	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
TO73_RS04190	COG1648	precorrin-2 dehydrogenase activity
TO73_RS04195	COG1587	Uroporphyrinogen-III synthase
TO73_RS04200	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
TO73_RS04205	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
TO73_RS04210	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TO73_RS04215	COG4558	Periplasmic binding protein
TO73_RS04220	COG0352	thiamine-phosphate diphosphorylase activity
TO73_RS04225	COG2104	thiamine diphosphate biosynthetic process
TO73_RS04230	COG2022	thiamine diphosphate biosynthetic process
TO73_RS04235	COG2022	thiamine diphosphate biosynthetic process
TO73_RS04235	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
TO73_RS04240	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
TO73_RS04245	COG0351	phosphomethylpyrimidine kinase
TO73_RS04255	COG0395	ABC-type sugar transport system, permease component
TO73_RS04290	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
TO73_RS04295	COG3328	transposase activity
TO73_RS04330	COG0588	phosphoglycerate mutase activity
TO73_RS04345	COG0318	PFAM AMP-dependent synthetase and ligase
TO73_RS04355	COG0559	Belongs to the binding-protein-dependent transport system permease family
TO73_RS04395	COG1028	Short-chain dehydrogenase reductase Sdr
TO73_RS04405	COG0318	PFAM AMP-dependent synthetase and ligase
TO73_RS04410	COG1028	Short-chain dehydrogenase reductase Sdr
TO73_RS04430	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
TO73_RS04435	COG0318	PFAM AMP-dependent synthetase and ligase
TO73_RS04440	COG2267	carboxylic ester hydrolase activity
TO73_RS04450	COG2030	dehydratase
TO73_RS04470	COG1129	ABC transporter
TO73_RS04480	COG1028	Short-chain dehydrogenase reductase Sdr
TO73_RS04485	COG2062	phosphohistidine phosphatase, SixA
TO73_RS04510	COG0395	ABC-type sugar transport system, permease component
TO73_RS04515	COG1175	transmembrane transport
TO73_RS04535	COG1785	Belongs to the alkaline phosphatase family
TO73_RS04540	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
TO73_RS04550	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
TO73_RS04620	COG1309	transcriptional regulator
TO73_RS04625	COG1960	acyl-CoA dehydrogenase activity
TO73_RS04630	COG1012	belongs to the aldehyde dehydrogenase family
TO73_RS04630	COG2030	dehydratase
TO73_RS04635	COG1028	Short-chain dehydrogenase reductase Sdr
TO73_RS04640	COG2193	ferroxidase activity
TO73_RS04645	COG1733	regulation of RNA biosynthetic process
TO73_RS04650	COG4974	Belongs to the 'phage' integrase family
TO73_RS04670	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
TO73_RS04705	COG1518	maintenance of DNA repeat elements
TO73_RS04715	COG3396	Phenylacetate-CoA oxygenase
TO73_RS04735	COG1012	belongs to the aldehyde dehydrogenase family
TO73_RS04735	COG2030	dehydratase
TO73_RS04750	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
TO73_RS04755	COG2050	protein possibly involved in aromatic compounds catabolism
TO73_RS04785	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
TO73_RS04790	COG2368	4-hydroxyphenylacetate
TO73_RS04795	COG1012	belongs to the aldehyde dehydrogenase family
TO73_RS04805	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
TO73_RS04815	COG1648	precorrin-2 dehydrogenase activity
TO73_RS04815	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
TO73_RS04860	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
TO73_RS04865	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
TO73_RS04870	COG0183	Belongs to the thiolase family
TO73_RS04875	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
TO73_RS04880	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
TO73_RS04900	COG1331	Highly conserved protein containing a thioredoxin domain
TO73_RS04905	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
TO73_RS04910	COG1960	acyl-CoA dehydrogenase activity
TO73_RS04915	COG2414	aldehyde ferredoxin oxidoreductase
TO73_RS04935	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
TO73_RS04955	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
TO73_RS04965	COG3383	formate dehydrogenase (NAD+) activity
TO73_RS04970	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
TO73_RS04975	COG0745	RESPONSE REGULATOR receiver
TO73_RS04980	COG5002	protein histidine kinase activity
TO73_RS04985	COG1960	acyl-CoA dehydrogenase activity
TO73_RS04990	COG2086	electron transfer activity
TO73_RS04995	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
TO73_RS05005	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
TO73_RS05010	COG1573	uracil-dna glycosylase
TO73_RS05015	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
TO73_RS05015	COG1796	DNA polymerase
TO73_RS05030	COG2873	o-acetylhomoserine
TO73_RS05040	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
TO73_RS05045	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
TO73_RS05045	COG1116	anion transmembrane transporter activity
TO73_RS05050	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
TO73_RS05055	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
TO73_RS05060	COG0215	cysteine-tRNA ligase activity
TO73_RS05065	COG1960	acyl-CoA dehydrogenase activity
TO73_RS05070	COG0183	Belongs to the thiolase family
TO73_RS05075	COG1250	3-hydroxyacyl-CoA dehydrogenase
TO73_RS05075	COG1024	Enoyl-CoA hydratase
TO73_RS05090	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
TO73_RS05100	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
TO73_RS05120	COG0726	polysaccharide deacetylase
TO73_RS05130	COG1811	Na channel or pump
TO73_RS05135	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
TO73_RS05140	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
TO73_RS05145	COG4948	Mandelate Racemase Muconate Lactonizing
TO73_RS05155	COG0402	S-adenosylhomocysteine deaminase activity
TO73_RS05185	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
TO73_RS05190	COG0742	ribosomal rna small subunit methyltransferase
TO73_RS05210	COG2873	o-acetylhomoserine
TO73_RS05215	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
TO73_RS05220	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
TO73_RS05235	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
TO73_RS05255	COG0149	triose-phosphate isomerase activity
TO73_RS05265	COG0126	phosphoglycerate kinase activity
TO73_RS05275	COG1268	BioY protein
TO73_RS05290	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
TO73_RS05305	COG1196	nuclear chromosome segregation
TO73_RS05320	COG2738	Putative neutral zinc metallopeptidase
TO73_RS05325	COG2897	thiosulfate sulfurtransferase activity
TO73_RS05330	COG1760	l-serine dehydratase
TO73_RS05335	COG2197	response regulator
TO73_RS05340	COG0335	large ribosomal subunit rRNA binding
TO73_RS05345	COG0336	Belongs to the RNA methyltransferase TrmD family
TO73_RS05350	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
TO73_RS05370	COG2239	Acts as a magnesium transporter
TO73_RS05380	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
TO73_RS05395	COG1692	metallophosphoesterase
TO73_RS05425	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
TO73_RS05435	COG0646	methionine synthase
TO73_RS05435	COG1410	methionine synthase
TO73_RS05440	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
TO73_RS05445	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
TO73_RS05450	COG0740	serine-type endopeptidase activity
TO73_RS05455	COG0544	peptidyl-prolyl cis-trans isomerase activity
TO73_RS05475	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
TO73_RS05480	COG3870	Protein conserved in bacteria
TO73_RS05490	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
TO73_RS05495	COG1293	RNA-binding protein homologous to eukaryotic snRNP
TO73_RS05500	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
TO73_RS05510	COG4475	Protein of unknown function (DUF436)
TO73_RS05525	COG1970	mechanosensitive ion channel activity
TO73_RS05530	COG3842	ATPase activity
TO73_RS05550	COG2176	DNA-directed DNA polymerase activity
TO73_RS05555	COG0154	amidase activity
TO73_RS05560	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
TO73_RS05570	COG1435	thymidine kinase activity
TO73_RS05575	COG0254	rRNA binding
TO73_RS05830	COG5005	Phage virion morphogenesis
TO73_RS05860	COG2001	Belongs to the MraZ family
TO73_RS05865	COG0275	rRNA processing
TO73_RS05890	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
TO73_RS05895	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
TO73_RS05900	COG0772	Belongs to the SEDS family
TO73_RS05905	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
TO73_RS05910	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
TO73_RS05915	COG0812	UDP-N-acetylmuramate dehydrogenase activity
TO73_RS05935	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
TO73_RS05940	COG2197	response regulator
TO73_RS05980	COG2391	methyltransferase activity
TO73_RS05985	COG1090	epimerase
TO73_RS05990	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
TO73_RS06000	COG1562	ergosterol biosynthetic process
TO73_RS06005	COG0415	Belongs to the DNA photolyase family
TO73_RS06040	COG1304	FMN binding
TO73_RS06080	COG1321	iron dependent repressor
TO73_RS06100	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TO73_RS06105	COG1120	ATPase activity
TO73_RS06140	COG0395	ABC-type sugar transport system, permease component
TO73_RS06165	COG1385	rRNA (uridine-N3-)-methyltransferase activity
TO73_RS06170	COG2264	protein methyltransferase activity
TO73_RS06180	COG0489	protein tyrosine kinase activity
TO73_RS06205	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
TO73_RS06215	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
TO73_RS06220	COG0134	indole-3-glycerol-phosphate synthase activity
TO73_RS06225	COG1752	Esterase of the alpha-beta hydrolase superfamily
TO73_RS06245	COG2358	TRAP transporter, solute receptor (TAXI family
TO73_RS06250	COG0765	amino acid transport
TO73_RS06255	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
TO73_RS06265	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
TO73_RS06270	COG0569	domain protein
TO73_RS06275	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TO73_RS06285	COG2313	pseudouridylate synthase activity
TO73_RS06295	COG3001	Fructosamine kinase
TO73_RS06300	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
TO73_RS06310	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
TO73_RS06315	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
TO73_RS06330	COG0012	GTP binding
TO73_RS06335	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
TO73_RS06345	COG0424	maF-like protein
TO73_RS06360	COG0768	penicillin binding
TO73_RS06370	COG2322	membrane
TO73_RS06390	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
TO73_RS06395	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
TO73_RS06405	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
TO73_RS06415	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
TO73_RS06420	COG4970	Tfp pilus assembly protein FimT
TO73_RS06445	COG1131	(ABC) transporter
TO73_RS06460	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
TO73_RS06475	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
TO73_RS06480	COG0440	acetolactate synthase activity
TO73_RS06485	COG0028	Belongs to the TPP enzyme family
TO73_RS06490	COG0492	ferredoxin-NADP+ reductase activity
TO73_RS06495	COG0861	Integral membrane protein TerC family
TO73_RS06510	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
TO73_RS06515	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
TO73_RS06525	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
TO73_RS06535	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
TO73_RS06540	COG1024	Enoyl-CoA hydratase
TO73_RS06545	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
TO73_RS06545	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
TO73_RS06565	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
TO73_RS06575	COG0423	glycine-tRNA ligase activity
TO73_RS06580	COG0542	response to heat
TO73_RS06585	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
TO73_RS06590	COG4956	integral membrane protein (PIN domain superfamily)
TO73_RS06615	COG1250	3-hydroxyacyl-CoA dehydrogenase
TO73_RS06620	COG0697	spore germination
TO73_RS06625	COG0612	Peptidase, M16
TO73_RS06630	COG0612	Peptidase, M16
TO73_RS06635	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
TO73_RS06660	COG1337	RAMP superfamily
TO73_RS06705	COG0419	ATPase involved in DNA repair
TO73_RS06710	COG0420	3'-5' exonuclease activity
TO73_RS06740	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
TO73_RS06745	COG2133	pyrroloquinoline quinone binding
TO73_RS06755	COG1063	alcohol dehydrogenase
TO73_RS06765	COG1254	Belongs to the acylphosphatase family
TO73_RS06770	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
TO73_RS06785	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
TO73_RS06790	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
TO73_RS06815	COG0183	Belongs to the thiolase family
TO73_RS06825	COG4970	Tfp pilus assembly protein FimT
TO73_RS06840	COG2165	general secretion pathway protein
TO73_RS06855	COG4636	protein conserved in cyanobacteria
TO73_RS06880	COG0180	Tryptophanyl-tRNA synthetase
TO73_RS06890	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
TO73_RS06895	COG0066	3-isopropylmalate dehydratase activity
TO73_RS06920	COG0129	dihydroxy-acid dehydratase activity
TO73_RS06925	COG2010	Cytochrome c
TO73_RS06935	COG1177	transmembrane transport
TO73_RS06940	COG1176	ABC-type spermidine putrescine transport system, permease component I
TO73_RS06945	COG3842	ATPase activity
TO73_RS06950	COG0772	Belongs to the SEDS family
TO73_RS06955	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
TO73_RS06960	COG2894	cell division
TO73_RS06965	COG1733	regulation of RNA biosynthetic process
TO73_RS06970	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
TO73_RS06970	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
TO73_RS06980	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TO73_RS06985	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TO73_RS06990	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TO73_RS07000	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
TO73_RS07015	COG2205	protein histidine kinase activity
TO73_RS07020	COG0745	RESPONSE REGULATOR receiver
TO73_RS07025	COG5002	protein histidine kinase activity
TO73_RS07025	COG2176	DNA-directed DNA polymerase activity
TO73_RS07030	COG0151	Belongs to the GarS family
TO73_RS07035	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
TO73_RS07040	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TO73_RS07045	COG0179	Fumarylacetoacetate (FAA) hydrolase
TO73_RS07050	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
TO73_RS07070	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
TO73_RS07075	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
TO73_RS07090	COG2514	catechol 2,3-dioxygenase activity
TO73_RS07095	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
TO73_RS07100	COG0287	Prephenate dehydrogenase
TO73_RS07110	COG0277	FAD linked oxidase domain protein
TO73_RS07135	COG1459	type II secretion system
TO73_RS07140	COG0009	L-threonylcarbamoyladenylate synthase
TO73_RS07145	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
TO73_RS07155	COG0456	acetyltransferase
TO73_RS07155	COG0454	-acetyltransferase
TO73_RS07160	COG1960	acyl-CoA dehydrogenase activity
TO73_RS07170	COG0312	modulator of DNA gyrase
TO73_RS07175	COG0312	modulator of DNA gyrase
TO73_RS07185	COG0730	response to heat
TO73_RS07195	COG0540	Belongs to the ATCase OTCase family
TO73_RS07200	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
TO73_RS07210	COG0167	dihydroorotate dehydrogenase activity
TO73_RS07220	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
TO73_RS07225	COG0746	molybdenum cofactor guanylyltransferase activity
TO73_RS07240	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TO73_RS07260	COG0473	3-isopropylmalate dehydrogenase activity
TO73_RS07265	COG0557	exoribonuclease II activity
TO73_RS07280	COG0585	pseudouridine synthase activity
TO73_RS07290	COG2050	protein possibly involved in aromatic compounds catabolism
TO73_RS07300	COG0322	excinuclease ABC activity
TO73_RS07310	COG0018	arginyl-trna synthetase
TO73_RS07315	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TO73_RS07320	COG1428	Deoxynucleoside kinase
TO73_RS07325	COG1428	Deoxynucleoside kinase
TO73_RS07330	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
TO73_RS07335	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
TO73_RS07345	COG0107	imidazoleglycerol-phosphate synthase activity
TO73_RS07350	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
TO73_RS07350	COG0140	phosphoribosyl-ATP diphosphatase activity
TO73_RS07355	COG1494	fructose-1,6-bisphosphatase
TO73_RS07385	COG0084	hydrolase, TatD family'
TO73_RS07400	COG0017	Asparaginyl-tRNA synthetase
TO73_RS07405	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
TO73_RS07410	COG1053	succinate dehydrogenase
TO73_RS07420	COG2009	succinate dehydrogenase
TO73_RS07425	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
TO73_RS07455	COG0318	PFAM AMP-dependent synthetase and ligase
TO73_RS07460	COG1104	cysteine desulfurase activity
TO73_RS07465	COG1959	2 iron, 2 sulfur cluster binding
TO73_RS07470	COG1108	ABC-type Mn2 Zn2 transport systems permease components
TO73_RS07475	COG1121	(ABC) transporter
TO73_RS07480	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
TO73_RS07485	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
TO73_RS07490	COG0232	Belongs to the dGTPase family. Type 2 subfamily
TO73_RS07495	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
TO73_RS07500	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
TO73_RS07505	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
TO73_RS07510	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
TO73_RS07515	COG0131	Imidazoleglycerol-phosphate dehydratase
TO73_RS07520	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
TO73_RS07585	COG4712	double-strand break repair protein
TO73_RS07595	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
TO73_RS07600	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TO73_RS07605	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TO73_RS07610	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TO73_RS07615	COG0649	NAD binding
TO73_RS07620	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
TO73_RS07625	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
TO73_RS07630	COG1034	ATP synthesis coupled electron transport
TO73_RS07635	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
TO73_RS07640	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TO73_RS07645	COG0839	Belongs to the complex I subunit 6 family
TO73_RS07650	COG0713	ATP synthesis coupled electron transport
TO73_RS07655	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
TO73_RS07660	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TO73_RS07665	COG1007	ATP synthesis coupled electron transport
TO73_RS07685	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
TO73_RS07690	COG1394	ATPase activity, coupled to movement of substances
TO73_RS07695	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
TO73_RS07700	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
TO73_RS07705	COG1436	Produces ATP from ADP in the presence of a proton gradient across the membrane
TO73_RS07710	COG1527	subunit (C
TO73_RS07715	COG1390	Produces ATP from ADP in the presence of a proton gradient across the membrane
TO73_RS07725	COG1269	ATP hydrolysis coupled proton transport
TO73_RS07770	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
TO73_RS07790	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
TO73_RS07800	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TO73_RS07810	COG0728	peptidoglycan biosynthetic process
TO73_RS07825	COG1316	TRANSCRIPTIONal
TO73_RS07840	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
TO73_RS07860	COG1573	uracil-dna glycosylase
TO73_RS07875	COG3842	ATPase activity
TO73_RS07885	COG0124	histidyl-tRNA synthetase
TO73_RS07895	COG0384	phenazine biosynthesis protein PhzF
TO73_RS07900	COG0561	phosphatase activity
TO73_RS07905	COG0017	Asparaginyl-tRNA synthetase
TO73_RS07910	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
TO73_RS07945	COG0702	epimerase
TO73_RS07950	COG1233	COG1233 Phytoene dehydrogenase and related
TO73_RS07970	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
TO73_RS07980	COG0640	Transcriptional regulator
TO73_RS07985	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
TO73_RS07995	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
TO73_RS08000	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
TO73_RS08005	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
TO73_RS08010	COG4636	protein conserved in cyanobacteria
TO73_RS08015	COG0006	proline dipeptidase activity
TO73_RS08020	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
TO73_RS08025	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
TO73_RS08030	COG1994	Peptidase M50
TO73_RS08040	COG0517	IMP dehydrogenase activity
TO73_RS08040	COG0617	tRNA 3'-terminal CCA addition
TO73_RS08040	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
TO73_RS08080	COG2189	Belongs to the N(4) N(6)-methyltransferase family
TO73_RS08105	COG0052	Belongs to the universal ribosomal protein uS2 family
TO73_RS08110	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
TO73_RS08115	COG0528	UMP kinase activity
TO73_RS08120	COG0233	cytoplasmic translational termination
TO73_RS08125	COG4589	Belongs to the CDS family
TO73_RS08130	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
TO73_RS08135	COG0750	zinc metalloprotease
TO73_RS08150	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
TO73_RS08155	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
TO73_RS08160	COG2359	stage V sporulation protein S
TO73_RS08170	COG2137	regulation of response to DNA damage stimulus
TO73_RS08180	COG1266	CAAX protease self-immunity
TO73_RS08185	COG2766	serine protein kinase
TO73_RS08195	COG2719	SpoVR family
TO73_RS08200	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
TO73_RS08205	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
TO73_RS08220	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
TO73_RS08240	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
TO73_RS08245	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
TO73_RS08250	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
TO73_RS08275	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TO73_RS08285	COG3191	aminopeptidase activity
TO73_RS08295	COG1063	alcohol dehydrogenase
TO73_RS08300	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
TO73_RS08315	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
TO73_RS08320	COG2884	Cell division ATP-binding protein ftsE
TO73_RS08325	COG0793	Belongs to the peptidase S41A family
TO73_RS08335	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TO73_RS08335	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TO73_RS08360	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
TO73_RS08365	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
TO73_RS08375	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
TO73_RS08380	COG0159	tryptophan synthase activity
TO73_RS08385	COG0133	tryptophan synthase activity
TO73_RS08390	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
TO73_RS08405	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
TO73_RS08410	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
TO73_RS08415	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
TO73_RS08420	COG1674	ftsk spoiiie
TO73_RS08435	COG0517	IMP dehydrogenase activity
TO73_RS08440	COG1605	Chorismate mutase
TO73_RS08440	COG0077	Prephenate dehydratase
TO73_RS08445	COG0745	RESPONSE REGULATOR receiver
TO73_RS08470	COG3845	ABC transporter
TO73_RS08475	COG1744	ABC transporter substrate-binding protein PnrA-like
TO73_RS08485	COG4651	solute:proton antiporter activity
TO73_RS08485	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
TO73_RS08490	COG0217	transcriptional regulatory protein
TO73_RS08495	COG0653	protein targeting
TO73_RS08500	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
TO73_RS08520	COG1111	helicase
TO73_RS08520	COG1205	dead DEAH box helicase
TO73_RS08535	COG0358	DNA primase activity
TO73_RS08550	COG2813	Specifically methylates the guanine in position
TO73_RS08570	COG0494	nUDIX hydrolase
TO73_RS08575	COG0196	riboflavin kinase activity
TO73_RS08580	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
TO73_RS08585	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
TO73_RS08590	COG0509	glycine decarboxylation via glycine cleavage system
TO73_RS08595	COG0404	The glycine cleavage system catalyzes the degradation of glycine
TO73_RS08610	COG0281	malic enzyme
TO73_RS08615	COG2151	metal-sulfur cluster biosynthetic enzyme
TO73_RS08620	COG0861	Integral membrane protein TerC family
TO73_RS08645	COG0564	pseudouridine synthase activity
TO73_RS08650	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
TO73_RS08655	COG2255	four-way junction helicase activity
TO73_RS08675	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
TO73_RS08685	COG1085	galactose-1-phosphate uridylyltransferase
TO73_RS08695	COG1181	Belongs to the D-alanine--D-alanine ligase family
TO73_RS08700	COG0193	aminoacyl-tRNA hydrolase activity
TO73_RS08705	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
TO73_RS08710	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
TO73_RS08715	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
TO73_RS08720	COG1854	S-ribosylhomocysteine lyase activity
TO73_RS08725	COG0518	GMP synthase (glutamine-hydrolyzing) activity
TO73_RS08725	COG0519	Catalyzes the synthesis of GMP from XMP
TO73_RS08730	COG4636	protein conserved in cyanobacteria
TO73_RS08735	COG4274	PFAM GYD family protein
TO73_RS08740	COG0346	lactoylglutathione lyase activity
TO73_RS08760	COG1131	(ABC) transporter
TO73_RS08765	COG0328	RNA-DNA hybrid ribonuclease activity
TO73_RS08770	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
TO73_RS08800	COG2832	Protein of unknown function (DUF454)
TO73_RS08810	COG0590	tRNA wobble adenosine to inosine editing
TO73_RS08810	COG0037	tRNA processing
TO73_RS08820	COG0277	FAD linked oxidase domain protein
TO73_RS08825	COG0277	FAD linked oxidase domain protein
TO73_RS08830	COG0247	lactate metabolic process
TO73_RS08860	COG0635	Involved in the biosynthesis of porphyrin-containing compound
TO73_RS08900	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
TO73_RS08910	COG0460	homoserine dehydrogenase
TO73_RS08915	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
TO73_RS08925	COG0815	Transfers the fatty acyl group on membrane lipoproteins
TO73_RS08930	COG0544	peptidyl-prolyl cis-trans isomerase activity
TO73_RS08935	COG2226	methyltransferase
TO73_RS08940	COG2226	methyltransferase
TO73_RS08945	COG0366	Alpha amylase catalytic
TO73_RS08955	COG0037	tRNA processing
TO73_RS08960	COG2104	thiamine diphosphate biosynthetic process
TO73_RS08965	COG0123	including yeast histone deacetylase and acetoin utilization protein
TO73_RS08970	COG0517	IMP dehydrogenase activity
TO73_RS08980	COG0444	Belongs to the ABC transporter superfamily
TO73_RS08985	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TO73_RS08990	COG0601	transmembrane transport
TO73_RS08995	COG0747	negative chemotaxis
TO73_RS09005	COG0492	ferredoxin-NADP+ reductase activity
TO73_RS09035	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TO73_RS09040	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
TO73_RS09055	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
TO73_RS09075	COG2070	2-Nitropropane dioxygenase
TO73_RS09080	COG0463	Glycosyl transferase, family 2
TO73_RS09090	COG0745	RESPONSE REGULATOR receiver
TO73_RS09095	COG5002	protein histidine kinase activity
TO73_RS09110	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
TO73_RS09120	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
TO73_RS09135	COG0513	Belongs to the DEAD box helicase family
TO73_RS09140	COG0303	'Molybdopterin
TO73_RS09160	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
TO73_RS09170	COG0442	prolyl-tRNA aminoacylation
TO73_RS09175	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
TO73_RS09185	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
TO73_RS09240	COG0789	Transcriptional regulator
TO73_RS09245	COG0484	heat shock protein binding
TO73_RS09250	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
TO73_RS09255	COG0443	Heat shock 70 kDa protein
TO73_RS09260	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
TO73_RS09265	COG0776	regulation of translation
TO73_RS09275	COG1515	deoxyribonuclease V activity
TO73_RS09285	COG1482	cell wall glycoprotein biosynthetic process
TO73_RS09290	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
TO73_RS09295	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
TO73_RS09305	COG2816	NAD+ diphosphatase activity
TO73_RS09310	COG1028	Short-chain dehydrogenase reductase Sdr
TO73_RS09335	COG0542	response to heat
TO73_RS09360	COG3118	belongs to the thioredoxin family
TO73_RS09380	COG0490	domain, Protein
TO73_RS09385	COG0475	glutathione-regulated potassium exporter activity
TO73_RS09400	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
TO73_RS09400	COG0517	IMP dehydrogenase activity
TO73_RS09400	COG0617	tRNA 3'-terminal CCA addition
TO73_RS09405	COG0475	glutathione-regulated potassium exporter activity
TO73_RS09415	COG0305	Participates in initiation and elongation during chromosome replication
TO73_RS09425	COG0067	glutamate synthase
TO73_RS09425	COG0069	glutamate synthase activity
TO73_RS09425	COG0070	glutamate synthase
TO73_RS09440	COG0516	GMP reductase activity
TO73_RS09440	COG0517	IMP dehydrogenase activity
TO73_RS09450	COG0745	RESPONSE REGULATOR receiver
TO73_RS09455	COG2205	protein histidine kinase activity
TO73_RS09460	COG0704	Plays a role in the regulation of phosphate uptake
TO73_RS09470	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
TO73_RS09495	COG3335	DDE superfamily endonuclease
TO73_RS09505	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
TO73_RS09515	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
TO73_RS09515	COG0515	serine threonine protein kinase
TO73_RS09540	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
TO73_RS09545	COG1028	Short-chain dehydrogenase reductase Sdr
TO73_RS09550	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
TO73_RS09550	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
TO73_RS09565	COG0717	Belongs to the dCTP deaminase family
TO73_RS09575	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
TO73_RS09580	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
TO73_RS09585	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
TO73_RS09605	COG0583	DNA-binding transcription factor activity
TO73_RS09610	COG3546	catalase activity
TO73_RS09615	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
TO73_RS09615	COG0758	DNA mediated transformation
TO73_RS09620	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
TO73_RS09630	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
TO73_RS09635	COG0372	Belongs to the citrate synthase family
TO73_RS09640	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
TO73_RS09645	COG0616	signal peptide processing
TO73_RS09685	COG1461	Dihydroxyacetone kinase
TO73_RS09695	COG0686	Belongs to the AlaDH PNT family
TO73_RS09700	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
TO73_RS09705	COG1024	Enoyl-CoA hydratase
TO73_RS09710	COG1187	pseudouridine synthase activity
TO73_RS09715	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
TO73_RS09730	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
TO73_RS09735	COG4636	protein conserved in cyanobacteria
TO73_RS09745	COG0512	Glutamine amidotransferase of anthranilate synthase
TO73_RS09750	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
TO73_RS09755	COG1012	belongs to the aldehyde dehydrogenase family
TO73_RS09760	COG0506	proline dehydrogenase activity
TO73_RS09780	COG0156	8-amino-7-oxononanoate synthase activity
TO73_RS09800	COG0187	DNA topoisomerase II activity
TO73_RS09805	COG1643	Atp-dependent helicase
TO73_RS09820	COG1063	alcohol dehydrogenase
TO73_RS09875	COG1605	Chorismate mutase
TO73_RS09875	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
TO73_RS09880	COG0805	protein transport
TO73_RS09885	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
TO73_RS09890	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
TO73_RS09895	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
TO73_RS09910	COG0686	Belongs to the AlaDH PNT family
TO73_RS09915	COG0427	acetyl-CoA hydrolase
TO73_RS09920	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
TO73_RS09925	COG2720	vancomycin resistance protein
TO73_RS09930	COG1187	pseudouridine synthase activity
TO73_RS09940	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
TO73_RS09945	COG1028	Short-chain dehydrogenase reductase Sdr
TO73_RS09950	COG0492	ferredoxin-NADP+ reductase activity
TO73_RS09960	COG0792	nuclease activity
TO73_RS09965	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
TO73_RS09980	COG0220	tRNA (guanine-N7-)-methyltransferase activity
TO73_RS09985	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
TO73_RS10000	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TO73_RS10010	COG1764	response to oxidative stress
TO73_RS10015	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
TO73_RS10030	COG3842	ATPase activity
TO73_RS10035	COG0101	tRNA pseudouridine synthase activity
TO73_RS10040	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TO73_RS10045	COG0601	transmembrane transport
TO73_RS10055	COG0316	Belongs to the HesB IscA family
TO73_RS10065	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
TO73_RS10080	COG1166	arginine decarboxylase activity
TO73_RS10090	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
TO73_RS10095	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
TO73_RS10105	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
TO73_RS10130	COG0366	Alpha amylase catalytic
TO73_RS10140	COG1193	negative regulation of DNA recombination
TO73_RS10165	COG2226	methyltransferase
TO73_RS10170	COG4603	Belongs to the binding-protein-dependent transport system permease family
TO73_RS10175	COG1079	Belongs to the binding-protein-dependent transport system permease family
TO73_RS10260	COG2414	aldehyde ferredoxin oxidoreductase
TO73_RS10290	COG1902	pentaerythritol trinitrate reductase activity
TO73_RS10310	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
TO73_RS10340	COG1131	(ABC) transporter
TO73_RS10370	COG3956	TIGRFAM MazG family protein
TO73_RS10380	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
TO73_RS10390	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
TO73_RS10395	COG1937	Protein conserved in bacteria
TO73_RS10405	COG0674	pyruvate-flavodoxin oxidoreductase activity
TO73_RS10405	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
TO73_RS10410	COG1013	pyruvate-flavodoxin oxidoreductase activity
TO73_RS10415	COG0315	cyclic pyranopterin monophosphate synthase activity
TO73_RS10440	COG0631	protein serine/threonine phosphatase activity
TO73_RS10445	COG0105	UTP biosynthetic process
TO73_RS10455	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
TO73_RS10485	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
TO73_RS10495	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
TO73_RS10505	COG0243	molybdopterin cofactor binding
TO73_RS10515	COG0301	tRNA thio-modification
TO73_RS10520	COG0154	amidase activity
TO73_RS10525	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
TO73_RS10540	COG0521	Mo-molybdopterin cofactor biosynthetic process
TO73_RS10545	COG0436	Aminotransferase
TO73_RS10550	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
TO73_RS10565	COG1404	Belongs to the peptidase S8 family
TO73_RS10575	COG0285	dihydrofolate synthase activity
TO73_RS10585	COG0181	hydroxymethylbilane synthase activity
TO73_RS10590	COG0508	dehydrogenase complex catalyzes the overall conversion of
TO73_RS10600	COG0583	DNA-binding transcription factor activity
TO73_RS10615	COG0735	belongs to the Fur family
TO73_RS10620	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
TO73_RS10630	COG0482	sulfurtransferase activity
TO73_RS10635	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
TO73_RS10640	COG0573	inorganic phosphate transmembrane transporter activity
TO73_RS10650	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
TO73_RS10655	COG2814	Major facilitator Superfamily
TO73_RS10660	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
TO73_RS10755	COG1845	cytochrome c oxidase, subunit III
TO73_RS10755	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
TO73_RS10760	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
TO73_RS10760	COG2010	Cytochrome c
TO73_RS10765	COG1612	heme a metabolic process
TO73_RS10765	COG0109	protoheme IX farnesyltransferase activity
TO73_RS10770	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
TO73_RS10775	COG0166	Belongs to the GPI family
TO73_RS10810	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
TO73_RS10845	COG0723	plastoquinol--plastocyanin reductase activity
TO73_RS10850	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
TO73_RS10855	COG0539	negative regulation of cytoplasmic translation
TO73_RS10885	COG1115	amino acid carrier protein
TO73_RS10905	COG1489	DNA binding
TO73_RS10935	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
TO73_RS10940	COG1355	regulation of microtubule-based process
TO73_RS10955	COG1011	Hydrolase
TO73_RS10970	COG0589	response to stress
TO73_RS10975	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
TO73_RS10980	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
TO73_RS11000	COG0302	gtp cyclohydrolase
TO73_RS11020	COG1217	gtp-binding protein TYPA
TO73_RS11030	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
TO73_RS11035	COG0395	ABC-type sugar transport system, permease component
TO73_RS11040	COG2361	Protein of unknown function DUF86
TO73_RS11050	COG1804	L-carnitine dehydratase bile acid-inducible protein F
TO73_RS11060	COG1131	(ABC) transporter
TO73_RS11080	COG0556	nucleotide-excision repair
TO73_RS11085	COG0497	DNA recombination
TO73_RS11090	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
TO73_RS11135	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
TO73_RS11150	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
TO73_RS11155	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
TO73_RS11190	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
TO73_RS11205	COG0346	lactoylglutathione lyase activity
TO73_RS11210	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
TO73_RS11215	COG0343	queuine tRNA-ribosyltransferase activity
TO73_RS11225	COG0628	permease
TO73_RS11235	COG0227	Belongs to the bacterial ribosomal protein bL28 family
TO73_RS11240	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
TO73_RS11250	COG1597	lipid kinase activity
TO73_RS11260	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
TO73_RS11260	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
TO73_RS11265	COG0123	including yeast histone deacetylase and acetoin utilization protein
TO73_RS11285	COG0004	ammonium transporteR
TO73_RS11290	COG0347	Belongs to the P(II) protein family
TO73_RS11300	COG0314	molybdopterin synthase activity
TO73_RS11310	COG4636	protein conserved in cyanobacteria
TO73_RS11315	COG0820	rRNA (adenine-C2-)-methyltransferase activity
TO73_RS11320	COG1960	acyl-CoA dehydrogenase activity
TO73_RS11330	COG0495	leucyl-tRNA aminoacylation
TO73_RS11345	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
TO73_RS11350	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
TO73_RS11365	COG2096	Adenosyltransferase
TO73_RS11375	COG4555	ABC transporter
TO73_RS11405	COG1660	Displays ATPase and GTPase activities
TO73_RS11410	COG0391	Required for morphogenesis under gluconeogenic growth conditions
TO73_RS11425	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
TO73_RS11430	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
TO73_RS11460	COG0205	6-phosphofructokinase activity
TO73_RS11465	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
TO73_RS11475	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
TO73_RS11495	COG0658	competence protein
TO73_RS11495	COG2333	competence protein COMEC
TO73_RS11500	COG1475	DNA binding
TO73_RS11505	COG1192	Involved in chromosome partitioning
TO73_RS11510	COG0357	Ribosomal RNA small subunit methyltransferase G
TO73_RS11515	COG0445	tRNA wobble uridine modification
TO73_RS11650	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
TO73_RS11700	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
TO73_RS11760	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
TO73_RS11960	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
TO73_RS12010	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
TO73_RS12190	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
TO73_RS12405	COG1496	oxidoreductase activity
TO73_RS12470	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors